CN108158630B - Intravascular thrombus catcher - Google Patents
Intravascular thrombus catcher Download PDFInfo
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- CN108158630B CN108158630B CN201810159203.3A CN201810159203A CN108158630B CN 108158630 B CN108158630 B CN 108158630B CN 201810159203 A CN201810159203 A CN 201810159203A CN 108158630 B CN108158630 B CN 108158630B
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- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 202
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0061—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physics & Mathematics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgical Instruments (AREA)
Abstract
The utility model provides an ware is arrested to endovascular thrombus, includes and gets the system of taking the bolt and conveying system, and the guiding sheath pipe, gets the system of taking the bolt and includes a self-expandable and gets the bolt support, and conveying system includes a push-and-pull seal wire, and push-and-pull seal wire is connected with getting the system of taking the bolt, and the guiding sheath pipe can be with getting the compression of system of taking the bolt folding and accomodate in, its characterized in that: the proximal end part of the thrombus taking support is of a tubular or cage-shaped structure formed by interconnecting a plurality of unit grids, and the distal end part of the thrombus taking support is of a net bag-shaped or bag-shaped structure formed by interconnecting a plurality of unit grids. The invention has the advantages of high thrombus capture rate, difficult falling of thrombus in the retracting process, good compliance of a conveying system, small damage to blood vessels in the thrombus taking process, and the like.
Description
Technical Field
The invention relates to a medical instrument for interventional therapy, in particular to an intravascular thrombus catcher, which belongs to the field of medical instruments.
Background
Acute cerebral thrombosis is mainly caused by cerebral vascular thrombosis, and is the most common fatal and disabling disease of the central nervous system. Cerebral thrombosis has the characteristics of high morbidity, high disability rate, high mortality rate and high recurrence rate. According to a statistical data of Beijing city, the incidence of acute cerebral hemorrhage in Beijing city is obviously reduced, but the incidence of acute cerebral thrombosis is obviously increased, namely the proportion of acute cerebral hemorrhage to cerebral apoplexy is reduced from 42% to 16%, and the proportion of acute cerebral thrombosis is increased from 55.8% to 81.6%, so that cerebral thrombosis is the first major brain disease.
Vascular recanalization is critical in the treatment of acute ischemic stroke. At present, two main methods for treating intracranial thrombosis are mainly adopted, namely, a mode of only drug thrombolysis and a mode of combining mechanical thrombolysis and drug thrombolysis. The thrombolysis medicine may be prepared through intravenous injection of rt-PA or urokinase to dissolve thrombus, or through intra-arterial contact thrombolysis, platelet aggregation resisting, anticoagulant medicine treatment, etc. Although thrombolytic therapy has been shown to better improve the prognosis of the nervous system, drug thrombolysis is subject to some urgent problems, firstly, the window of thrombolysis time is short, the national institute of neurological and stroke (The National Institute Neurological Disorders and Stroke rt-PA Stroke Study Group, NINDS) considers that venous thrombolysis should be performed within 3 hours of onset, arterial thrombolysis time window should be within 6 hours, and such short window of thrombolysis time that only 4.5% -6.3% of patients can receive thrombolytic therapy, secondly, the vascular recanalization time of drug thrombolysis is long, and the vascular recanalization time may be one of the important factors affecting the clinical prognosis, and whether venous thrombolysis or arterial thrombolysis, the vascular recanalization time is at least 1-2 hours, and again, thrombolytic therapy is only suitable for small-volume thrombi and has unsatisfactory therapeutic effects on large-volume thrombi; and some patients are not suitable for thrombolytic therapy.
In order to solve the problem of thrombolysis of the drugs, the hot spot of research in recent years is eliminated by adopting a mechanical mode. The mechanical thrombus removing method comprises the following steps: aspiration of thrombus, capture of thrombus, laser thrombus breaking. The effect of sucking thrombus is better when small emboli are taken, but when the emboli are larger, the emboli at the far end can easily escape, and the process is troublesome and the blood vessel is easily injured; the existing method for taking the thrombus by the catcher is simple to operate, has less damage to the blood vessel, but can not catch the thrombus frequently, and often needs to take the thrombus for many times or needs to suck by using a guide catheter during catching, otherwise small fragments falling off from the thrombus can escape and block the blood vessel at the far end; the method has the advantages of high operation difficulty, ineffectiveness when the laser energy is too low, damage to blood vessels when the laser energy is too high, and easy occurrence of various complications.
Chinese patent No. cn10317258. B discloses an intracranial vessel thrombus removing device, which comprises a thrombus removing device, a guide wire, a push-pull guide wire and an outer sheath tube, wherein the thrombus removing device is connected with the push-pull guide wire, the mounted push-pull guide wire and the thrombus removing device are pressed and held in the outer sheath tube, the thrombus removing device is pushed out of the outer sheath tube in an unfolding position, and a certain number of inner protruding parts are arranged on the inner wall of the thrombus removing device.
The Chinese patent application CN104000635.A discloses a thrombus taking device and a thrombus taking device, wherein the thrombus taking device is of a net structure and limits a lumen, the thrombus taking device can be switched between a retracted position and an extended position, a plurality of concave stems extending into the three-dimensional outline of the lumen are arranged on the net structure of the thrombus taking device, and two ends of the concave stems are fixed on the net structure.
The thrombus catcher with the reticular tubular structure is simple to operate, but the thrombus is hung by the stent grid, the thrombus is positioned between the periphery of the stent and the inner wall of a blood vessel, even if the thrombus is additionally provided with an inner bulge or is connected with an inner concave rod, the thrombus which can be chopped in the stent unfolding process cannot be avoided, formed fragments are likely to fall off in the retracting process of a thrombus pulling device, the thrombus taking effect is unreliable, and in order to overcome the problem, doctors often need to use a balloon guide catheter in a matched manner, and the blood flow is blocked by utilizing the balloon so as to prevent the fallen thrombus fragments from being flushed to the blood vessel at the far end by blood flow; because of the adherence of the embolectomy device of the reticular lumen to the blood vessel, if the radial force of the stent is improperly adjusted and is too large, the damage to the inner wall of the blood vessel can be quite large.
In the invention 'thrombus remover' of patent number ZL200620164685.4 of Chinese bulletin, a two-long and one-short three-jaw umbrella with elastic memory function and a net attached on the periphery form a thrombus removing device with a circular structure, and the three jaws are closed by pulling a push-pull rod outwards to recover thrombus in the umbrella part into an outer sleeve, so that the thrombus is taken out.
US 2009/024338 a1 discloses an embolic device having a self-expanding snare secured to the distal end of an elongate shaft and a collapsible bag of flexible, non-porous material attached thereto, the device being placed in embolic position along an internal body passageway by the elongate shaft, the bag being opened to enclose a thrombus therein.
Although the basket-shaped thrombus remover can prevent the escape of thrombus fragments to a certain extent, the basket-shaped thrombus remover has obvious defects that the basket-shaped thrombus remover often has overlarge volume and cannot be used in cerebral arteries such as middle cerebral arteries M1 and M2 with smaller blood vessel diameters.
The Chinese patent application CN20110222609. X and the Chinese patent application CN20110281795. X disclose a thrombus aspiration catheter, which comprises an aspiration tube, wherein the aspiration tube comprises a tube seat, the tube seat is connected with the catheter, a sleeve is movably sleeved on the outer wall of the aspiration tube, the sleeve comprises a Y-shaped connector, a double-cavity tube and a balloon, the Y-shaped connector is connected with the double-cavity tube, the balloon is arranged on the outer wall of the far end of the double-cavity tube, an interference metal wire can be included in the aspiration tube, and the far end of the interference metal wire can extend out of the far end of the aspiration tube. The thrombus taking system can quickly remove thrombus scattered in a wide area of blood vessels and treat embolism of coronary peripheral microvasculature, and when thrombus with large volume and Gao Ru thick is encountered, the thrombus can be scattered by using a disturbing wire and then sucked.
Another thrombus aspiration catheter is disclosed in US patent application 2010/0049147 A1. U.S. patent application US2007/0161963A1 also discloses a thrombectomy aspiration catheter system.
The above-mentioned aspiration thrombus-taking system works well when getting small pieces of thrombus, but need to smash repeatedly the thrombus again after sucking in order to prevent to block up the suction tube when getting big pieces of thrombus, the process is troublesome and hurt the blood vessel very easily.
As is clear from the above discussion, the above-described thrombolytic devices in the patent documents, as well as the existing thrombolytic techniques, all have one or more drawbacks. Accordingly, there is a need for further improvements in the art, and it is desirable to design a better vascular thrombolytic device.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide an intravascular thrombus catcher, which has the following characteristics: firstly, keep the characteristics that the operation of the thrombus catcher of the reticular tubular structure is simple and the damage to the blood vessel is small, optimize the structure and improve the thrombus catching rate of the thrombus catcher. The thrombus catcher needs to have higher stability on the caught thrombus, and the broken thrombus is not easy to fall off when the thrombus catcher is retracted; secondly, the radial supporting force of the thrombus catcher needs to be moderate, so that the damage to the vessel wall of the device is reduced as much as possible; thirdly, the effective working length of the thrombus taking support, which can be contacted with thrombus, of the thrombus capturing device with the reticular tubular structure is as long as possible, and the ineffective transition part is as short as possible so as to ensure that the thrombus taking support has smaller total length, thereby reducing the risk of the thrombus taking support on vascular injury; fourth, the compliance of the conveying system is good, can convey to the intracranial thinner distal end blood vessel; fifthly, the thrombus catcher has certain developing property, and ensures that a doctor can clearly identify and judge the state of the thrombus taking system by using a DSA (digital subtraction angiography) technology.
The invention is realized by the following technical scheme:
The utility model provides an ware is arrested to endovascular thrombus, includes and gets the system of taking the bolt and conveying system, and guiding sheath pipe, gets the system of taking the bolt and includes a self-expandable and gets the bolt support, and conveying system includes a push-and-pull seal wire, and push-and-pull seal wire is connected with getting the system of taking the bolt, and guiding sheath pipe can be with getting the compression of the system of taking the bolt folding and accomodate in, its characterized in that: the proximal end part of the thrombus taking support is of a tubular or cage-shaped structure formed by interconnecting a plurality of unit grids, and the distal end part of the thrombus taking support is of a net bag-shaped or bag-shaped structure formed by interconnecting a plurality of unit grids.
In the process of releasing the thrombus taking system in the blood vessel, the tubular or cage-shaped structural part at the proximal end of the thrombus taking bracket is released at the position of the target thrombus, the net bag-shaped or bag-shaped structural part at the distal end of the thrombus taking bracket is released at the distal end of the target thrombus, the net bag-shaped or bag-shaped structural part at the distal end of the thrombus taking bracket is cut into the thrombus by virtue of the self-expansion effect of the tubular or cage-shaped structural part at the proximal end of the thrombus taking bracket to hang the whole target thrombus, and the net bag-shaped or bag-shaped structural part at the distal end of the thrombus taking bracket is self-expanded to open to form a protective net at the distal end, and then in the process of withdrawing the thrombus taking system with the thrombus outside the body, when the thrombus is cut by the net bag-shaped or bag-shaped structural part at the distal end of the thrombus taking bracket is cut by the net bag-shaped or bag-shaped structural part and is escaped from the proximal end of the thrombus taking bracket, and the thrombus is blocked by the net bag-shaped or bag-shaped structural part at the distal end of the thrombus taking bracket and is contained inside. The structure effectively solves the defect that the thrombus catcher with the traditional reticular tubular structure only depends on the support grid to hang thrombus, and the broken fallen thrombus can escape along the periphery of the support distally.
In the context of the present invention, the terms "distal" and "proximal" should be understood as viewed from the direction of the attending physician. The distal end is thus the side remote from the attending physician, while the proximal end represents the side towards the attending physician. If the phrase "axial" is used in this document, it is understood to mean the direction in which the device of the invention is advanced, i.e. the longitudinal axis of the device also coincides with the longitudinal axis of the vessel along which the device is advanced. The effective length of the thrombus taking bracket is as follows: the thrombus taking support has the functions of catching thrombus and preventing broken thrombus from escaping in the thrombus taking process. The invalid length refers to: the thrombus taking support plays a role in transition of connection and does not play a direct role in catching thrombus.
The technical scheme is further described as follows: the far end of the thrombus taking support is of a net bag-shaped or bag-shaped structure, the near end of the thrombus taking support is a large opening area formed by interconnecting larger unit grids, and the far end of the thrombus taking support is a closed closing area formed by interconnecting smaller unit grids and intersecting the furthest end of the thrombus taking support. The large opening area at the proximal end can enable thrombus to fall into the net bag-shaped or bag-shaped structure more easily, and the distal end adopts smaller unit grids and meets and closes up at the most distal end, so that the net bag-shaped thrombus which has fallen into the bracket can be formed.
The technical scheme is further described as follows: the closed closing-in area of the net bag-shaped or bag-shaped structure at the distal end of the thrombus taking support can be shaped into a hemispherical shape. The hemispherical distal end can provide better supporting force for the distal end structure, and the hemispherical structure is not easy to be changed by tortuous blood vessels, so that the structure has better vascular compliance and vascular adherence.
The technical scheme is further described as follows: the proximal tubular or cage-like structure of the thrombus-taking stent has proximal unit grids which are connected with each other and meet at the nearest end to form a transitional closing-in area. The nearest ends of the brackets are intersected to form a closing-in area, the area is an invalid transition part between the connection point position of the thrombus taking bracket and the push-pull guide wire and the tubular effective length of the thrombus taking bracket, and the invalid length with the transition function can be as short as possible.
The technical scheme is further described as follows: the thrombus taking support is a metal support which is made of a shape memory alloy pipe with super-elasticity effect through laser engraving and is subjected to post-shaping treatment. The metal bracket made of the shape memory alloy has enough radial supporting force, can ensure good adherence, has super-elasticity, can cause the thrombus taking bracket to generate great deformation after receiving external circumferential constraint force, and can still completely recover to the shape after removing the constraint force. This feature can compress the outer diameter of the thrombus-delivery stent so that it can fit into a microcatheter with delivery device function.
The technical scheme is further described as follows: the bolt taking system comprises an X-ray impermeable developing ring, and the X-ray impermeable developing ring is arranged at the connecting position of the bolt taking bracket and the push-pull guide wire. The clinician may monitor the radiopaque imaging ring by a angiographic device, such as DSA (digital subtraction angiography), to learn the proximal-most position of the stent within the vessel.
The technical scheme is further described as follows: the embolic system includes a protective head end in the form of an X-ray opaque spring coil at the distal-most location of the embolic stent. The clinician can monitor the X-ray-proof protection head end through vascular imaging equipment such as DSA (digital subtraction angiography), so as to know the most distal position of the thrombus taking support in the blood vessel, and meanwhile, the protection head end adopts a soft spring ring form, so that the damage to the blood vessel caused by the fact that the most distal end of the thrombus taking support directly abuts against the blood vessel wall due to misoperation when the apparatus is taken out of the microcatheter can be avoided.
The technical scheme is further described as follows: the embolectomy system includes X-ray opaque filaments wrapped around the rods of a partial cell grid of the embolectomy stent. The clinician can monitor the X-ray opaque filaments by using a vascular imaging device, such as DSA (digital subtraction angiography), and can know the fully opened and compressed state of the thrombus by looking at the positions of the filaments so as to further judge the catching condition of the thrombus by the thrombus taking stent.
The technical scheme is further described as follows: the push-pull guide wire is coated with a lubricating coating, and the lubricating coating is a PTFE coating or a hydrophilic coating. The lubricating coating reduces the resistance of the instrument in the push-pull process and increases the control performance of the instrument.
The technical scheme is further described as follows: the guiding sheath tube is made of polymer material polytetrafluoroethylene. The guiding sheath tube can shrink the bolt taking system into the guiding sheath tube, the inner diameter of the guiding sheath tube can be equal to the inner diameter of the micro-catheter, and the whole device is conveniently sent into the micro-catheter; the polytetrafluoroethylene material has a low friction coefficient, and reduces the resistance of the instrument in pushing the microcatheter.
The technical scheme is further described as follows: the push-pull guide wire adopts a design of gradual change diameter, the diameter of the far end is small, and the diameter of the near end is large. The small diameter of the distal end of the push-pull guide wire ensures that the distal end of the push-pull guide wire is soft enough and has smaller curvature radius, so that the push-pull guide wire is better suitable for tortuous vessels at the distal end of the brain, and the thicker diameter of the proximal end ensures that the push-pull guide wire has certain hardness to the distal end, thereby providing reliable supporting strength for pushing the bolt taking system in the microcatheter.
The technical scheme is further described as follows: the delivery system includes a support coil wrapped around a portion of the length of the distal thin diameter push-pull guidewire. The supporting spring ring plays a role in strengthening the supporting strength of the push-pull guide wire with the thin diameter at the far end so as to improve the transmission efficiency of the near-end pushing force to the far-end taking system by the push-pull guide wire, and meanwhile, the supporting spring ring can adopt alloy containing platinum, has the characteristic of no X-ray transmission and can enable the push-pull guide wire to have developing capability.
Compared with the prior art, the invention has the following advantages:
Firstly, keep its net tubular structure's thrombus capture ware easy operation to and the injury to the blood vessel is also less characteristics, make the thrombus capture ware have higher stability to the capture of thrombus, and broken thrombus is difficult for droing when withdrawing.
Secondly, the radial supporting force of the thrombus catcher is moderate, so that the damage to the vessel wall of the device is reduced as much as possible.
Thirdly, the effective working length of the thrombus taking support is long, the ineffective length of the transitional effect is short, the thrombus taking support is guaranteed to have smaller total length, and therefore the risk of injury of the thrombus taking support to blood vessels is reduced.
Fourth, the push guidewire of the present invention is flexible and can be delivered to, for example, intracranial finer distal vessels.
Fifthly, the thrombus catcher has certain developing property, and ensures that a doctor can clearly identify and judge the state of the thrombus taking system by using a DSA (digital subtraction angiography) technology.
Drawings
Examples of the invention will be explained by the following drawings:
Fig. 1 is a schematic view showing the structure of an example of an intravascular thrombus catcher of the present invention.
Fig. 2 is a schematic three-dimensional structural view of the exemplary embolectomy system of fig. 1.
Fig. 3 is a schematic structural view of a thrombus-harvesting system of an example of another intravascular thrombus-catcher of the present invention, having X-ray opaque filaments wrapped around the rods of a partial cell grid of a thrombus-harvesting stent.
Fig. 4 is a schematic illustration of the exemplary embolectomy system of fig. 3, with the visualization of the instrument as seen by a physician using DSA (digital subtraction angiography) techniques.
Fig. 5 is a schematic view (one) of the process of removing an intravascular target thrombus according to the example shown in fig. 1.
Fig. 6 is a schematic view (II) showing a process of removing an intravascular target thrombus according to the example shown in fig. 1.
Fig. 7 is a schematic view (III) of the process of removing an intravascular target thrombus according to the example shown in fig. 1.
Fig. 8 is a schematic view (fourth) of the process of removing an intravascular target thrombus according to the example shown in fig. 1.
Fig. 9 is a schematic diagram (fifth) showing the process of removing an intravascular target thrombus according to the example shown in fig. 1.
Detailed Description
In accordance with the principles of the present invention, several examples of thrombus traps are disclosed herein with reference to the above figures. The examples disclosed herein are but a few of the examples of this invention. The details of the detailed disclosure merely serve as a basis for the claims and to teach one skilled in the relevant art how to suitably apply the invention.
Fig. 1 shows an example of an intravascular thrombus capture device according to the present invention, comprising a embolization system comprising a self-expandable embolization stent (100), and a delivery system comprising a push-pull guidewire (200), wherein the push-pull guidewire (200) is coupled to the embolization system, the proximal portion of the embolization stent (100) is a tubular or cage-like structure comprising a plurality of cellular grids interconnected, and the distal portion of the embolization stent (100) is a net-like or bag-like structure comprising a plurality of cellular grids interconnected. The thrombus taking bracket (100) is a shape memory alloy pipe with super-elasticity effect by laser engraving, and is made of a metal bracket by post-shaping treatment, and the alloy material of the metal bracket can be nickel-titanium alloy with super-elasticity property. The bolt taking system comprises an X-ray-impermeable developing ring (110), platinum iridium alloy can be adopted as a material of the developing ring (110) at the connecting position of the bolt taking support (100) and the push-pull guide wire (200), and the bolt taking system comprises an X-ray-impermeable spring ring-shaped protection head end (120) which is positioned at the most distal position of the bolt taking support (100), and platinum tungsten alloy can be adopted as a material of the protection head end (120). The push-pull guide wire (200) adopts a design with gradually changed diameter, the diameter of the far end is small, the diameter of the near end is large, the length is 180cm, the material of the push-pull guide wire can adopt super-elastic nickel-iron alloy, the good flexibility of the push-pull guide wire is ensured, and the push-pull guide wire (200) is coated with a lubricating coating which is a PTFE coating. The lubricating coating reduces the resistance of the instrument in the push-pull process and increases the control performance of the instrument. The guiding sheath tube (300) can be used for compressing and folding the taking and bolting system and is accommodated in the guiding sheath tube (300), the guiding sheath tube (300) is made of polytetrafluoroethylene, the inner diameter of the guiding sheath tube (300) is equal to the inner diameter of the micro-catheter (400), and the length is preferably 65mm. As shown in fig. 2, the far-end net bag-shaped or bag-shaped structure of the thrombus taking support (100) has a large opening area (101) formed by interconnecting larger unit grids, the far-end net bag-shaped or bag-shaped structure has a closed closing area (102) formed by interconnecting smaller unit grids and intersecting the far-end net bag-shaped structure, and the closed closing area (102) of the net bag-shaped or bag-shaped structure of the far-end of the thrombus taking support (100) can be shaped into a hemispherical shape, so that thrombus falling from the near-end of the thrombus taking support (100) can fall into the large opening area (101) and can be received and blocked by the closed closing area (102). Proximal tubular or cage-like structures of the stent (100) are interconnected by proximal cell grids that meet at the proximal end to form a transition constriction region (103).
Fig. 3 shows another example of an intravascular thrombus capture of the present invention, differing from the example shown in fig. 1 in that: the embolectomy system of this example includes X-ray opaque filaments (130) wrapped around the rods of a partial cell grid of the embolectomy stent (100). According to the trajectory shown in fig. 3, a spiral is wound on the bars of the cell grid. When a clinician uses a angiographic device, such as a DSA (digital subtraction angiography), he will observe on the device screen a developed image of the fully opened embolectomy system, which image is shown in fig. 4, the clinician knows the opened and thrombosed compressed state of the embolectomy stent (100) by looking at the position of the radiopaque filaments (130), and thus determines the capture of the target thrombus (500) by the embolectomy stent (100).
The following is an illustration of the clinician using the example shown in fig. 1: the clinician uses DSA (digital subtraction angiography) to angiography the patient to determine the location of the target thrombus (500) within the vessel (600). The distal end of the micro-catheter (400) is conveyed to a position which exceeds the target thrombus (500) by a certain distance by adopting a conventional vascular puncture interventional technology, namely, the position is shown in fig. 5, then a proper amount of contrast agent is pushed into the micro-catheter (400), angiography of the distal end of the thrombus is carried out, the approximate length of the target thrombus (500) is judged, and a thrombus catcher with a proper specification is selected. The example of fig. 1 is then advanced into a microcatheter (400) using the guiding action of the introducer sheath (300) and gradually pushing the entire instrument. When the X-ray opaque protective tip (120) of the thrombus removal system reaches the most distal end of the microcatheter (400), i.e., the position shown in fig. 6, the microcatheter (400) is kept motionless relative to the human body and retracted proximally, the thrombus removal stent (100) is deployed at the target thrombus (500) position as the microcatheter (400) is retracted, the cell mesh of the tubular or cage-like structural part at the proximal end of the thrombus removal stent (100) cuts itself into the target thrombus (500) to hold the thrombus in its entirety, and the net-like or bag-like structural part at the distal end of the thrombus removal stent (100) is self-expanded to form a distal protective net, and the most distal end of the microcatheter (400) is retracted all the way to the position of the developing ring (110) of the thrombus removal system, as shown in fig. 7. After waiting for more than 3 minutes, the thrombus taking support (100) is fully expanded, and after a doctor judges that the target thrombus (500) is well caught, the whole example shown in fig. 1 and the microcatheter (400) are quickly retracted, and if the thrombus which is cut up and falls off is caught by a string bag-shaped or bag-shaped structural part at the far end of the thrombus taking support (100), as shown in fig. 8. When the thrombus taking support (100) for capturing the target thrombus (500) is retracted to the inlet of the guide catheter (700), the inner diameter of the guide catheter (700) is larger than that of the micro catheter (400), but the inner diameter of the guide catheter is smaller than that of the blood vessel (600), so that thrombus at the part outside the thrombus taking support (100) can be remained outside the guide catheter (700), a doctor can select to draw negative pressure on the guide catheter (700) to enable the thrombus staying at the orifice to enter the guide catheter (700), and the thrombus at the orifice can be brought back by utilizing the net bag-shaped or bag-shaped structural part at the distal end of the thrombus taking support (100) in the embodiment, because the thrombus separated from the proximal end of the thrombus taking support (100) can be caught by the net bag at the distal end of the thrombus taking support (100). The final extraction system withdraws the example device which wraps the target thrombus (500) from the body, thereby completing the whole extraction process.
Claims (5)
1. The utility model provides an ware is arrested to endovascular thrombus, includes and gets the system of taking the bolt and conveying system, and the guiding sheath pipe, gets the system of taking the bolt and includes a self-expandable and gets the bolt support, and conveying system includes a push-and-pull seal wire, and push-and-pull seal wire is connected with getting the system of taking the bolt, and the guiding sheath pipe can be with getting the compression of system of taking the bolt folding and accomodate in, its characterized in that: the thrombus taking support is provided with an effective length and an ineffective length, wherein the effective length refers to a part of the thrombus taking support which has the effects of catching thrombus and preventing broken thrombus from escaping in the thrombus taking process, and the ineffective length refers to a part of the thrombus taking support which has the transitional effect of connection and does not have a direct effect on catching thrombus; the proximal end part of the thrombus taking support is a tubular or cage-shaped structure which is formed by connecting a plurality of unit grids, is unfolded at the position of a target thrombus and cuts into the target thrombus to hang the whole thrombus, and the distal end part of the thrombus taking support is a net bag-shaped or bag-shaped structure formed by connecting a plurality of unit grids; the proximal end of the net bag-shaped or bag-shaped structure of the distal end of the thrombus taking support is a large opening area which is formed by interconnecting larger unit grids and is used for enabling thrombus to fall into the net bag-shaped or bag-shaped structure, and the distal end of the net bag-shaped or bag-shaped structure is a closed closing area which is formed by interconnecting smaller unit grids and is intersected at the most distal end of the smaller unit grids; the proximal unit grids of the thrombus taking support are connected with each other and are intersected and converged at the nearest end to form a transition closing-in area, and the transition closing-in area is an ineffective transition part between the position of the connecting point of the thrombus taking support and the push-pull guide wire and the tubular effective length of the thrombus taking support; the closed closing-in area of the net bag-shaped or bag-shaped structure at the distal end of the thrombus taking support can be shaped into a hemispherical shape; the bolt taking system comprises X-ray opaque filaments which are spirally wound on the rods of part of the unit grids of the bolt taking bracket; the push-pull guide wire is coated with a lubricating coating, and the lubricating coating is a PTFE coating.
2. An intravascular thrombus catcher as in claim 1 wherein: the thrombus taking support is a metal support which is made of a shape memory alloy pipe with super-elasticity effect through laser engraving and is subjected to post-shaping treatment.
3. An intravascular thrombus catcher as in claim 1 wherein: the bolt taking system comprises an X-ray impermeable developing ring, and the X-ray impermeable developing ring is arranged at the connecting position of the bolt taking bracket and the push-pull guide wire.
4. An intravascular thrombus catcher as in claim 1 wherein: the embolic system includes a protective head end in the form of an X-ray opaque spring coil at the distal-most location of the embolic stent.
5. An intravascular thrombus catcher as in claim 1 wherein: the guiding sheath tube is made of polymer material polytetrafluoroethylene.
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| CN201810159203.3A CN108158630B (en) | 2018-02-26 | 2018-02-26 | Intravascular thrombus catcher |
| CN202010912055.5A CN111904675B (en) | 2018-02-26 | 2018-02-26 | Thrombus taking support and thrombus capturing device |
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| CN201810159203.3A CN108158630B (en) | 2018-02-26 | 2018-02-26 | Intravascular thrombus catcher |
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Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108158630B (en) * | 2018-02-26 | 2024-06-07 | 上海加奇生物科技苏州有限公司 | Intravascular thrombus catcher |
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| CN109331321B (en) * | 2018-09-27 | 2022-02-11 | 湖南埃普特医疗器械有限公司 | Guide wire catching device |
| CN109692027A (en) * | 2018-12-03 | 2019-04-30 | 北京泰杰伟业科技有限公司 | A kind of whole course visible takes thrombus device |
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| CN112043347A (en) * | 2020-09-16 | 2020-12-08 | 江苏暖阳医疗器械有限公司 | Integrated embolectomy support |
| CN116458960A (en) * | 2020-09-21 | 2023-07-21 | 苏州恒瑞宏远医疗科技有限公司 | Self-expanding stent, thrombus taking stent and manufacturing method thereof |
| CN112155658B (en) * | 2020-10-29 | 2022-03-18 | 上海加奇生物科技苏州有限公司 | Thrombus taking bracket and thrombus catcher |
| CN113081169A (en) * | 2021-04-30 | 2021-07-09 | 齐聚医疗科技(上海)有限公司 | Intravascular device and vascular thrombus removal device |
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| CN114098904A (en) * | 2021-11-10 | 2022-03-01 | 北京泰杰伟业科技有限公司 | Thrombus collection device |
| CN114652394A (en) * | 2022-04-06 | 2022-06-24 | 苏州恒瑞宏远医疗科技有限公司 | Intravascular thrombus taking-out device |
| CN117771015A (en) * | 2022-09-22 | 2024-03-29 | 神途医疗科技(上海)有限公司 | Embolic protection device and medical instrument |
| CN115836927B (en) * | 2022-12-06 | 2023-05-09 | 杭州亿科医疗科技有限公司 | Bolt taking system |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764170A (en) * | 2012-07-18 | 2012-11-07 | 吕文峰 | Intravascular stent with complex functions |
| WO2014081077A1 (en) * | 2012-11-26 | 2014-05-30 | 연세대학교 원주산학협력단 | Stent module for removing blood clots |
| CN106580397A (en) * | 2016-12-20 | 2017-04-26 | 北京久事神康医疗科技有限公司 | Sectional thrombus extraction device and thrombus extraction method making use of thrombus extraction device |
| CN106955140A (en) * | 2017-05-09 | 2017-07-18 | 心凯诺医疗科技(上海)有限公司 | One kind takes bolt support and thrombus withdrawing device |
| CN107198554A (en) * | 2016-09-23 | 2017-09-26 | 赛诺医疗科学技术有限公司 | One kind takes bolt apparatus |
| CN107212913A (en) * | 2017-04-30 | 2017-09-29 | 沈阳新智源医疗用品有限公司 | A kind of support with thrombus capturing means takes bolt device |
| CN111904675A (en) * | 2018-02-26 | 2020-11-10 | 上海加奇生物科技苏州有限公司 | Thrombus taking bracket and thrombus catcher |
| CN213641088U (en) * | 2018-02-26 | 2021-07-09 | 上海加奇生物科技苏州有限公司 | Intravascular thrombus capture device |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9211396B2 (en) * | 2010-02-23 | 2015-12-15 | Covidien Lp | Devices and methods for vascular recanalization |
| US11083473B2 (en) * | 2015-02-06 | 2021-08-10 | Rapid Medical Ltd. | Systems and methods for intravascular obstruction removal |
| CN105997314B (en) * | 2016-06-30 | 2018-06-08 | 南京普微森医疗科技有限公司 | A kind of thrombus of complex function eliminates system |
| CN106618676B (en) * | 2016-12-30 | 2020-07-28 | 上海加奇生物科技苏州有限公司 | Intravascular thrombus taking-out device |
-
2018
- 2018-02-26 CN CN201810159203.3A patent/CN108158630B/en active Active
- 2018-02-26 CN CN202010912055.5A patent/CN111904675B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764170A (en) * | 2012-07-18 | 2012-11-07 | 吕文峰 | Intravascular stent with complex functions |
| WO2014081077A1 (en) * | 2012-11-26 | 2014-05-30 | 연세대학교 원주산학협력단 | Stent module for removing blood clots |
| CN107198554A (en) * | 2016-09-23 | 2017-09-26 | 赛诺医疗科学技术有限公司 | One kind takes bolt apparatus |
| CN106580397A (en) * | 2016-12-20 | 2017-04-26 | 北京久事神康医疗科技有限公司 | Sectional thrombus extraction device and thrombus extraction method making use of thrombus extraction device |
| CN107212913A (en) * | 2017-04-30 | 2017-09-29 | 沈阳新智源医疗用品有限公司 | A kind of support with thrombus capturing means takes bolt device |
| CN106955140A (en) * | 2017-05-09 | 2017-07-18 | 心凯诺医疗科技(上海)有限公司 | One kind takes bolt support and thrombus withdrawing device |
| CN111904675A (en) * | 2018-02-26 | 2020-11-10 | 上海加奇生物科技苏州有限公司 | Thrombus taking bracket and thrombus catcher |
| CN213641088U (en) * | 2018-02-26 | 2021-07-09 | 上海加奇生物科技苏州有限公司 | Intravascular thrombus capture device |
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| CN111904675A (en) | 2020-11-10 |
| CN111904675B (en) | 2023-04-25 |
| CN108158630A (en) | 2018-06-15 |
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