CN108152768A - A kind of NMR signal acquisition processing device - Google Patents
A kind of NMR signal acquisition processing device Download PDFInfo
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- CN108152768A CN108152768A CN201711227275.9A CN201711227275A CN108152768A CN 108152768 A CN108152768 A CN 108152768A CN 201711227275 A CN201711227275 A CN 201711227275A CN 108152768 A CN108152768 A CN 108152768A
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- 238000012545 processing Methods 0.000 title claims abstract description 59
- 238000006243 chemical reaction Methods 0.000 claims abstract description 18
- 239000007787 solid Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 abstract description 9
- 238000002595 magnetic resonance imaging Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 7
- 230000003321 amplification Effects 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 238000003199 nucleic acid amplification method Methods 0.000 description 6
- 230000003993 interaction Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/32—Excitation or detection systems, e.g. using radio frequency signals
- G01R33/36—Electrical details, e.g. matching or coupling of the coil to the receiver
- G01R33/3621—NMR receivers or demodulators, e.g. preamplifiers, means for frequency modulation of the MR signal using a digital down converter, means for analog to digital conversion [ADC] or for filtering or processing of the MR signal such as bandpass filtering, resampling, decimation or interpolation
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- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention discloses a kind of NMR signal acquisition processing device, which includes：Power module, Collection processing module, core processing module, data memory module, MCU control module and display module.The prime signal acquisition module of the present apparatus realizes the reception of analog signal, include being amplified to inputting analog signal, anti-aliasing bandpass filtering and analog-to-digital conversion.Digital signal enters core processing module and is handled, and is equipped with control module collaboration processing；Data are stored in DDR3.The present invention has specific aim and universality, and the data receiver processing for magnetic resonance imaging provides a high performance feasibility platform, has very big realistic meaning.
Description
Technical field
The present invention relates to analog signal processing, the conversion of analog to digital signal, FPGA design, embedded system field, especially
It is related to a kind of NMR signal acquisition processing device.
Background technology
Magnetic resonance imaging skill relies on its characteristic without resolution ratio between invasive, non-invasive and ground, is increasingly becoming and faces
One of very important tool in bed medical diagnosis and biomedical research in its continuous development, also carries technical device
Increasingly higher demands are gone out.
Existing acquisition of magnetic resonance signals device for input signal can range of receiving it is small, the acquisition for original signal
Precision is low, the application scenarios of high precision collecting data is needed to be difficult to reach its standard relative to clinical medicine etc..
Invention content
The purpose of the present invention is in view of the deficiencies of the prior art and propose a kind of NMR signal acquisition processing device,
It realizes the acquisition input to the small-signal of volt grade range, gain-adjusted range for millivolt level and is up to 60dB, stepping is accurate to
0.5dB.Analog signal after amplitude is conditioned carries out further signal processing by being passed into FPGA after analog-digital conversion,
Finally obtain required magnetic resonance signal data.
The object of the present invention is achieved like this：
A kind of NMR signal acquisition processing device, feature are that the device includes：Power module, Collection processing mould
Block, core processing module, data memory module, MCU control module and display module.At the power module and Collection
Manage module, core processing module, data memory module, MCU control module and display module connection；The core processing module with
Believe Collection processing module, data memory module and MCU control module connection.The MCU control module is adopted with small-signal
Collect processing module, core processing module and display module connection；Wherein, the Collection processing module includes the first order
Gating switch I, first order fixed gain amplifier, first order gating switch II, second level gating switch I, the second level, which are fixed, to be increased
Beneficial amplifier, second level gating switch II, bandpass filter, variable gain amplifier and analog-digital conversion chip, described
Level-one fixed gain amplifier is connect with first order gating switch I, first order gating switch II；The first order gating switch II
It is connect with second level gating switch I；Second level fixed gain amplifier and second level gating switch I, second level gating switch II
Connection；The bandpass filter is connect with second level gating switch II, variable gain amplifier；The analog-digital conversion core
Piece is connect with variable gain amplifier.
Fixed gain amplifier, variable gain amplifier and gating switch in the Collection processing module,
Three, which cascades, to be used, and amplitude adjusted is carried out to input signal.
The core processing module selects the Spartan-6 Series FPGAs of Xilinx companies.
The MCU control module selects the STM32F407 chips of STMicroelectronics companies.
Compared with prior art, the beneficial effects of the invention are as follows：
1）The present invention realizes the acquisition input to the small-signal of volt grade range, gain-adjusted range for millivolt level and is up to
60dB, stepping are accurate to 0.5dB.
2）The present invention realizes resolution ratio and reaches 16bit analog-to-digital conversions, and sample frequency is more than 100MHz.It substantially increases and adopts
The precision of sample data.
3）The present invention use FPGA for core processor and be equipped with STM32 be MCU control module association handle, realize more
Friendly, more complete signal processing model.
Description of the drawings
Fig. 1 is structure diagram of the present invention；
Fig. 2 is Collection processing module structure diagram of the present invention；
Fig. 3 is signal processing flow of the present invention；
Fig. 4 is small signal acquisition process module structure diagram in the embodiment of the present invention 1；
Fig. 5 is small signal acquisition process module structure diagram in the embodiment of the present invention 2；
Fig. 6 is small signal acquisition process module structure diagram in the embodiment of the present invention 2；
Fig. 7 is small signal acquisition process module structure diagram in the embodiment of the present invention 3.
Specific embodiment
Refering to Fig. 1, the present invention includes：
Power module 1, external power supply input interface and including power supply chip, have stablize the 9V, 5V exported, 3.3V, 3V, 2.5V,
1.8V, 1.5V, 1.2V, 0.75V amount to 9 kinds of voltages, and respectively Collection processing module, core processing module, data are deposited
It stores up module, MCU control module and display module and respectively required voltage is provided；
Collection processing module 2 is connected with power module 1 and core processing module 3, goes forward side by side for receiving input signal
Row amplification, filtering, analog-digital conversion；
Core processing module 3 connect with Collection processing module 2, data memory module 4 and MCU control module 5, is used for
The data from Collection processing module 2 received are handled, carry out the operations such as Digital Down Convert, bandwidth varying filtering；
Data memory module 4 is connected with core processing module 3, completes the function of data storage；
MCU control module 5 is connected with Collection processing module 2 and core processing module 3, completes the biography of control instruction
Function that is defeated and being interacted with peripheral hardware；
Display module 6 is connected with MCU control module 5, for the display of required significant data.
Embodiment 1
Refering to Fig. 1, Fig. 3 and Fig. 4, by taking the magnetic resonance signal for inputting 10mvpp as an example.Input signal initially enters Collection
Processing module 2 provides order, control first order gating switch I 7 and first order gating switch II by MCU control module 5 at this time
9, gating first order fixed gain amplifier 8 controls second level gating switch I 10 and second level gating switch II 12, gating the
Two level fixed gain amplifier 11, two-stage have progress+30dB amplifications altogether.Signal is carried out anti-aliasing by bandpass filter 13 later
Band logical pre-filtering filters off out-of-band noise.Order is provided by MCU control module 5 again, controls variable gain amplifier 14, carry out+
16dB amplifies, and so far, third stage amplifier has realization+46dB amplifications altogether so that signal reaches 2vpp, this is analog-digital conversion
The preferable input value of chip.Analog-digital conversion chip 15 is entered back into later and carries out analog-digital conversion, this process needs MCU
Control module 5 is controlled.At this point, the magnetic resonance signal of digital signal has been converted into from Collection processing module 2
It is exported by LVDS interface, is passed to core processing module 3 and carries out the operations such as Digital Down Convert, bandwidth varying filtering.Period needs
Data interaction is carried out with data memory module 4 and MCU control module 5.The display module 6 controlled by MCU control module 5, can
With significant data needed for display.So far a whole set of acquisition and processing to NMR signal are completed.
Embodiment 2
Refering to Fig. 1, Fig. 3, Fig. 5 and Fig. 6, by taking the magnetic resonance signal for inputting 200mvpp as an example.Input signal initially enters small-signal
Acquisition processing module 2, provides order by MCU control module 5 at this time, and control first order gating switch I 7 and first order gating are opened
II 9 are closed, gating first order fixed gain amplifier 8 controls second level gating switch I 10 and second level gating switch II 12,
Second level fixed gain amplifier 11 is not gated, and two-stage has progress+15dB amplifications altogether.Or it does not gate first order fixed gain and puts
Big device 8, gating second level fixed gain amplifier 11 can obtain same result.Later signal by bandpass filter 13 into
The anti-aliasing band logical pre-filtering of row filters off out-of-band noise.Order is provided by MCU control module 5 again, controls variable gain amplifier 14,
Progress+5dB amplifies, and so far, third stage amplifier has realization+20dB amplifications altogether so that signal reaches 2vpp, this is analog to digital
The preferable input value of conversion chip.Analog-digital conversion chip 15 is entered back into later and carries out analog-digital conversion, this process needs
MCU control module 5 is wanted to be controlled.At this point, the magnetic resonance signal for being converted into digital signal handles mould from Collection
It is exported in block 2 by LVDS interface, is passed to core processing module 3 and carries out the operations such as Digital Down Convert, bandwidth varying filtering.Period
It needs to carry out data interaction with data memory module 4 and MCU control module 5.The display module controlled by MCU control module 5
6, it can show required significant data.So far a whole set of acquisition and processing to NMR signal are completed.
Embodiment 3
Refering to Fig. 1, Fig. 3 and Fig. 7, by taking the magnetic resonance signal for inputting 4vpp as an example.Input signal is initially entered at Collection
Module 2 is managed, order, control first order gating switch I 7 and first order gating switch II 9 are provided by MCU control module 5 at this time,
First order fixed gain amplifier 8 is not gated, is controlled second level gating switch I 10 and second level gating switch II 12, is not gated
Second level fixed gain amplifier 11, two-stage is without amplification.Signal carries out anti-aliasing band logical by bandpass filter 13 later
Pre-filtering filters off out-of-band noise.Order is provided by MCU control module 5 again, controls variable gain amplifier 14, progress -6dB contractings
Small, so far, third stage amplifier has realization -6dB diminutions altogether so that signal reaches 2vpp, this is the reason of analog-digital conversion chip
Think input value.Analog-digital conversion chip 15 is entered back into later and carries out analog-digital conversion, this process needs MCU control module
5 are controlled.At this point, the magnetic resonance signal for being converted into digital signal passes through LVDS from Collection processing module 2
Interface exports, and is passed to core processing module 3 and carries out the operations such as Digital Down Convert, bandwidth varying filtering.Period needs are deposited with data
It stores up module 4 and MCU control module 5 carries out data interaction.The display module 6 controlled by MCU control module 5, can show institute
Need significant data.So far a whole set of acquisition and processing to NMR signal are completed.
Claims (3)
1. a kind of NMR signal acquisition processing device, it is characterised in that the device includes：Power module（1）, small-signal adopts
Collect processing module（2）, core processing module（3）, data memory module（4）, MCU control module（5）And display module（6）, institute
State power module（1）With Collection processing module（2）, core processing module（3）, data memory module（4）, MCU control
Module（5）And display module（6）Connection；The core processing module（3）With believing Collection processing module（2）, data deposit
Store up module（4）And MCU control module（5）Connection；The MCU control module（5）With Collection processing module（2）, core
Processing module（3）And display module（6）Connection；Wherein, the Collection processing module（2）Including first order gating switch
Ⅰ（7）, first order fixed gain amplifier（8）, first order gating switch II（9）, second level gating switch I（10）, the second level it is solid
Determine gain amplifier（11）, second level gating switch II（12）, bandpass filter（13）, variable gain amplifier（14）And mould
Plan-number conversion chip（15）, the first order fixed gain amplifier（8）With first order gating switch I（7）, the first order choosing
Open up pass II（9）Connection；The first order gating switch II（9）With second level gating switch I（10）Connection；The second level is consolidated
Determine gain amplifier（11）With second level gating switch I（10）, second level gating switch II（12）Connection；The bandpass filter
（13）With second level gating switch II（12）, variable gain amplifier（14）Connection；The analog-digital conversion chip（15）With
Variable gain amplifier（14）Connection.
2. NMR signal acquisition processing device according to claim 1, it is characterised in that：The core processing module
Select the Spartan-6 Series FPGAs of Xilinx companies.
3. NMR signal acquisition processing device according to claim 1, it is characterised in that：The MCU control module
Select the STM32F407 chips of STMicroelectronics companies.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711227275.9A CN108152768A (en) | 2017-11-29 | 2017-11-29 | A kind of NMR signal acquisition processing device |
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| CN201711227275.9A CN108152768A (en) | 2017-11-29 | 2017-11-29 | A kind of NMR signal acquisition processing device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109471394A (en) * | 2018-12-03 | 2019-03-15 | 华东师范大学 | A kind of multi-channel wide dynamic range high-speed signal acquisition processing unit |
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|---|---|---|---|---|
| US5828216A (en) * | 1996-08-19 | 1998-10-27 | The United States Of America As Represented By The Department Of Health And Human Services | Gated RF preamplifier for use in pulsed radiofrequency electron paramagnetic resonance and MRI |
| CN101207403A (en) * | 2007-12-19 | 2008-06-25 | 哈尔滨工程大学 | Broadband radio frequency front end of intermediate wave frequency band high dynamic range |
| CN106059520A (en) * | 2016-05-25 | 2016-10-26 | 吉林大学 | Real-time anti-saturation device and real-time anti-saturation method for amplifier in magnetic resonance water exploration system |
| CN106526513A (en) * | 2016-10-10 | 2017-03-22 | 上海理工大学 | Magnetic resonance receiver based on heterogeneous double cores |
| CN206362943U (en) * | 2017-01-09 | 2017-07-28 | 吉林大学 | Water signal supervisory instrument is visited in a kind of magnetic resonance with HDR |
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2017
- 2017-11-29 CN CN201711227275.9A patent/CN108152768A/en active Pending
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| US5828216A (en) * | 1996-08-19 | 1998-10-27 | The United States Of America As Represented By The Department Of Health And Human Services | Gated RF preamplifier for use in pulsed radiofrequency electron paramagnetic resonance and MRI |
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| CN106059520A (en) * | 2016-05-25 | 2016-10-26 | 吉林大学 | Real-time anti-saturation device and real-time anti-saturation method for amplifier in magnetic resonance water exploration system |
| CN106526513A (en) * | 2016-10-10 | 2017-03-22 | 上海理工大学 | Magnetic resonance receiver based on heterogeneous double cores |
| CN206362943U (en) * | 2017-01-09 | 2017-07-28 | 吉林大学 | Water signal supervisory instrument is visited in a kind of magnetic resonance with HDR |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109471394A (en) * | 2018-12-03 | 2019-03-15 | 华东师范大学 | A kind of multi-channel wide dynamic range high-speed signal acquisition processing unit |
| CN109471394B (en) * | 2018-12-03 | 2023-09-26 | 华东师范大学 | Multichannel wide dynamic range high-speed signal acquisition processing device |
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