CN108125828A - The preparation method of natural antibacterial agent - Google Patents
The preparation method of natural antibacterial agent Download PDFInfo
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- CN108125828A CN108125828A CN201711339626.5A CN201711339626A CN108125828A CN 108125828 A CN108125828 A CN 108125828A CN 201711339626 A CN201711339626 A CN 201711339626A CN 108125828 A CN108125828 A CN 108125828A
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- tea
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- antibacterial agent
- natural antibacterial
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Dermatology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses the preparation method of natural antibacterial agent, including tea free pretreatment, tea tree oil extract, the preparation of chitosan solution and the preparation of antiseptic.It has the beneficial effect that：Process is simple, mild condition, and product quality stability is good, cheap, and prepared antibacterial antiplaque agent effect is good, and antibacterial time is long, and with biodegradability, environmentally safe；Water vapour can touch the different parts of tea free in tea oil extraction process, enable water vapour fully penetrated to each position of tea free cell tissue, tea oil is made to be come into full contact with water vapour, by tea oil solution modeling, so as to improve the recovery rate of tea oil, tea free resource is made to be fully used, there is significant economic benefit.
Description
Technical field
The present invention relates to antiseptic preparation field, more particularly, to the preparation method of natural antibacterial agent.
Background technology
With social development, itself health care consciousness of people is constantly enhancing, and personal hygiene nursing materials gradually tends to work(
Energyization, wherein, the bactericidal function of product is concerned.So safe, nuisanceless, strong functional green resists, antibacterial production
The target that product become producer and retailer chases jointly.China is located in subtropical zone and Temperate Region in China, totally has a moderate climate, and is well suited for
The growth of various microorganisms.Especially moist rainy south, various pathogenic bacterias, mould and saccharomycete amount reproduction, seriously
Ground threatens health.Therefore, in recent years antiseptic develop obtain extensive concern.
Invention content
The object of the present invention is to provide the preparation methods of natural antibacterial agent, and this method is simple for process, and raw material is easy to get, cost compared with
Low, prepared antibacterial antiplaque agent effect is good, and antibacterial time is long, and with biodegradability, environmentally safe.
In order to achieve the above object, technical solution provided by the invention is：The preparation method of natural antibacterial agent, including following
Step：
Tea free pre-processes：Tea free is dried in the shade, is crushed, 10 mesh sieve is crossed, obtains tea free powder, under this condition, with the crushing
The tea free of fineness and the contact area of water are big, and tea tree leaf cell is easier broken wall, reduce the resistance of tea tree oil extract, and 10
Purpose smashing fineness will not generate sticky phenomenon, and tea oil loss is few during fever is crushed；
Tea tree oil extract：Water is added in tea free powder and carries out steam distillation extraction, and filtering and concentrating obtains tea tree oil extract, should
Extraction conditions are mild, small to the structure destruction of tea oil, improve the drug effect of antiseptic, antiseptic is made to have reached good antibacterial
Effect, and the tea oil color and luster extracted is relatively preferable, provides the exterior quality of antiseptic；
The preparation of chitosan solution：Chitosan is dissolved in acetic acid solution, obtains chitosan solution；
The preparation of antiseptic：By tea tree oil extract, chitosan solution and Tween 80 2-4 by volume:10-12:0.1-
0.14 mixing, ultrasonic disperse obtain natural antibacterial agent, and process is simple, mild condition, and product quality stability is good, and price is low
Honest and clean, prepared antibacterial antiplaque agent effect is good, and antibacterial time is long, and with biodegradability, environmentally safe.
Preferably, the solid-liquid ratio of tea free powder and water is 1g in tea oil extraction process:13-18mL.The solid-liquid ratio
Under, cost is controllable, and operating process is relatively easy to control, and the tea oil recovery rate of gained is high.
Preferably, the time of steam distillation extraction is 3-4h.Under the time, water vapour can touch tea free
Different parts enable water vapour fully penetrated to make tea oil abundant with water vapour to each position of tea free cell tissue
Contact, by tea oil solution modeling, so as to improve the recovery rate of tea oil, makes tea free resource be fully used, and has
There is significant economic benefit.
Preferably, the solid-liquid ratio of a concentration of 1%-2% of acetic acid solution, chitosan and acetic acid solution is 1g:7-12mL.It should
Under the conditions of, chitosan solution can fully dissolve, and the acetic acid under the ratio has synergistic effect with chitosan, can make micro- life
Object protein structure destroys, in microbial body biochemical process be obstructed, metabolic disorder, cause microorganism dead, improve antiseptic
Antibacterial effect.
Preferably, supersonic frequency is 25-35kHz, ultrasonic time 40-50min.Under this condition, spitting mixture
Uniform mixture is formed under the addition of temperature 80, improves the quality of antiseptic, and the mixing physical performance generated under the frequency
Stablize, be not easy to be layered.
Compared with prior art, beneficial effects of the present invention are：Process is simple, mild condition, and product quality is stablized
Property it is good, cheap, prepared antibacterial antiplaque agent effect is good, and antibacterial time is long, and with biodegradability, to environment without
Pollution；Water vapour can touch the different parts of tea free in tea oil extraction process, and water vapour fully penetrated is enable to arrive
Each position of tea free cell tissue, makes tea oil be come into full contact with water vapour, by tea oil solution modeling, so as to improve
The recovery rate of tea oil makes tea free resource be fully used, and has significant economic benefit.
Specific embodiment
It is described in further detail by the following examples：
Embodiment 1：The preparation method of natural antibacterial agent, includes the following steps：
1) tea free pre-processes：Tea free is dried in the shade, is crushed with medicinal herb grinder, 10 mesh sieve is crossed, obtains tea free powder, the condition
Under, the contact area of tea free and water with the smashing fineness is big, and tea tree leaf cell is easier broken wall, reduces tea oil and carries
The resistance taken, and the smashing fineness of 10 mesh will not generate sticky phenomenon, tea oil loss is few during fever is crushed；
2) tea tree oil extract：By solid-liquid ratio 1g:13mL adds in water to tea free powder and carries out steam distillation extraction 3h, and filtering is dense
Contract to obtain tea tree oil extract, and the extraction conditions are mild, small to the structure destruction of tea oil, improves the drug effect of antiseptic, makes to resist
Microbial inoculum has reached good antibacterial effect, and the tea oil color and luster extracted is relatively preferable, provides the exterior quality of antiseptic；
3) preparation of chitosan solution：By solid-liquid ratio 1g:Chitosan is dissolved in a concentration of 1% acetic acid solution by 7mL, obtains chitosan
Solution, under the conditions of, chitosan solution can fully dissolve, and the acetic acid under the ratio has synergistic effect with chitosan, can
Destroy microprotein structure, in microbial body biochemical process be obstructed, metabolic disorder, cause microorganism dead, improve
The antibacterial effect of antiseptic；
4) preparation of antiseptic：By tea tree oil extract, chitosan solution and Tween 80 by volume 2:10:0.1 mixing,
Ultrasonic disperse 40min obtains natural antibacterial agent under frequency 25kHz, and process is simple, mild condition, and product quality stability is good,
Cheap, prepared antibacterial antiplaque agent effect is good, and antibacterial time is long, and with biodegradability, environmentally safe.
Embodiment 2：The preparation method of natural antibacterial agent, includes the following steps：
1) tea free pre-processes：Tea free is dried in the shade, is crushed with medicinal herb grinder, 10 mesh sieve is crossed, obtains tea free powder, the condition
Under, the contact area of tea free and water with the smashing fineness is big, and tea tree leaf cell is easier broken wall, reduces tea oil and carries
The resistance taken, and the smashing fineness of 10 mesh will not generate sticky phenomenon, tea oil loss is few during fever is crushed；
2) tea tree oil extract：By solid-liquid ratio 1g:18mL adds in water to tea free powder and carries out steam distillation extraction 4h, and filtering is dense
Contract to obtain tea tree oil extract, and the extraction conditions are mild, small to the structure destruction of tea oil, improves the drug effect of antiseptic, makes to resist
Microbial inoculum has reached good antibacterial effect, and the tea oil color and luster extracted is relatively preferable, provides the exterior quality of antiseptic；
3) preparation of chitosan solution：By solid-liquid ratio 1g:Chitosan is dissolved in a concentration of 2% acetic acid solution by 12mL, obtains chitosan
Solution, under the conditions of, chitosan solution can fully dissolve, and the acetic acid under the ratio has synergistic effect with chitosan, can
Destroy microprotein structure, in microbial body biochemical process be obstructed, metabolic disorder, cause microorganism dead, improve
The antibacterial effect of antiseptic；
4) preparation of antiseptic：By tea tree oil extract, chitosan solution and Tween 80 by volume 4:12:0.14 mixing,
Ultrasonic disperse 50min obtains natural antibacterial agent under frequency 35kHz, and process is simple, mild condition, product quality stability
Good, cheap, prepared antibacterial antiplaque agent effect is good, and antibacterial time is long, and with biodegradability, to environment without dirt
Dye.
Embodiment 3：The preparation method of natural antibacterial agent, includes the following steps：
1) tea free pre-processes：Tea free is dried in the shade, is crushed with medicinal herb grinder, 10 mesh sieve is crossed, obtains tea free powder, the condition
Under, the contact area of tea free and water with the smashing fineness is big, and tea tree leaf cell is easier broken wall, reduces tea oil and carries
The resistance taken, and the smashing fineness of 10 mesh will not generate sticky phenomenon, tea oil loss is few during fever is crushed；
2) tea tree oil extract：By solid-liquid ratio 1g:14mL adds in water to tea free powder and carries out steam distillation extraction 3.5h, filtering
Tea tree oil extract is concentrated to give, the extraction conditions are mild, small to the structure destruction of tea oil, improve the drug effect of antiseptic, make
Antiseptic has reached good antibacterial effect, and the tea oil color and luster extracted is relatively preferable, provides the exterior quality of antiseptic；
3) preparation of chitosan solution：By solid-liquid ratio 1g:Chitosan is dissolved in a concentration of 1.5% acetic acid solution by 8mL, is obtained shell and is gathered
Sugar juice, under the conditions of, chitosan solution can fully dissolve, and the acetic acid under the ratio has synergistic effect, energy with chitosan
Enough destroy microprotein structure, in microbial body biochemical process be obstructed, metabolic disorder, cause microorganism dead, improve
The antibacterial effect of antiseptic；
4) preparation of antiseptic：By tea tree oil extract, chitosan solution and Tween 80 by volume 3:11:0.12 mixing,
Ultrasonic disperse 41min obtains natural antibacterial agent under frequency 26kHz, and process is simple, mild condition, product quality stability
Good, cheap, prepared antibacterial antiplaque agent effect is good, and antibacterial time is long, and with biodegradability, to environment without dirt
Dye.
Embodiment 4：The preparation method of natural antibacterial agent, includes the following steps：
1) tea free pre-processes：Tea free is dried in the shade, is crushed with medicinal herb grinder, 10 mesh sieve is crossed, obtains tea free powder, the condition
Under, the contact area of tea free and water with the smashing fineness is big, and tea tree leaf cell is easier broken wall, reduces tea oil and carries
The resistance taken, and the smashing fineness of 10 mesh will not generate sticky phenomenon, tea oil loss is few during fever is crushed；
2) tea tree oil extract：By solid-liquid ratio 1g:15mL adds in water to tea free powder, adds and accounts for tea tree leaf quality 1.2%
P-aminobenzoic acid, the pulullan polysaccharide for accounting for tea tree leaf quality 0.2% and the glutaric anhydride for accounting for tea tree leaf quality 0.31%, into
Row steam distillation extracts 3h, and filtering and concentrating obtains tea tree oil extract, and the extraction conditions are mild, and the structure of tea oil is destroyed
It is small, the drug effect of antiseptic is improved, antiseptic is made to have reached good antibacterial effect, and the tea oil color and luster extracted is relatively
It is good, the exterior quality of antiseptic is provided, the pulullan polysaccharide added in, glutaric anhydride and p-aminobenzoic acid have collaboration
Effect, significantly improves the rate that tea oil generates soluble complexes in water, improves the extraction efficiency of tea oil, make tea
Leaf is fully used, and reduces final cost；
3) preparation of chitosan solution：By solid-liquid ratio 1g:Chitosan is dissolved in a concentration of 1% acetic acid solution by 9mL, obtains chitosan
Solution, under the conditions of, chitosan solution can fully dissolve, and the acetic acid under the ratio has synergistic effect with chitosan, can
Destroy microprotein structure, in microbial body biochemical process be obstructed, metabolic disorder, cause microorganism dead, improve
The antibacterial effect of antiseptic；
4) preparation of antiseptic：By tea tree oil extract, chitosan solution and Tween 80 by volume 3:10:0.1 mixing,
Ultrasonic disperse 43min obtains natural antibacterial agent under frequency 30kHz, and process is simple, mild condition, and product quality stability is good,
Cheap, prepared antibacterial antiplaque agent effect is good, and antibacterial time is long, and with biodegradability, environmentally safe.
Embodiment of above is merely to illustrate the present invention, and not limitation of the present invention, the ordinary skill people of this field
Member without departing from the spirit and scope of the present invention, can also make a variety of changes and modification.Therefore, it is all equivalent
Technical solution also belong to scope of the invention, scope of patent protection of the invention should be defined by the claims.
Claims (5)
1. the preparation method of natural antibacterial agent, it is characterised in that：The preparation method includes the following steps：
1) tea free pre-processes：Tea free is dried in the shade, is crushed, 10 mesh sieve is crossed, obtains tea free powder；
2) tea tree oil extract：Water is added in tea free powder and carries out steam distillation extraction, and filtering and concentrating obtains tea tree oil extract；
3) preparation of chitosan solution：Chitosan is dissolved in acetic acid solution, obtains chitosan solution；
4) preparation of antiseptic：By tea tree oil extract, chitosan solution and Tween 80 2-4 by volume:10-12:0.1-
0.14 mixing, ultrasonic disperse obtain natural antibacterial agent.
2. the preparation method of natural antibacterial agent according to claim 1, it is characterised in that：Tea free powder in the step 2)
The solid-liquid ratio of end and water is 1g:13-18mL.
3. the preparation method of natural antibacterial agent according to claim 1, it is characterised in that：Water vapour steams in the step 2)
The time for evaporating extraction is 3-4h.
4. the preparation method of natural antibacterial agent according to claim 1, it is characterised in that：Acetic acid solution in the step 3)
A concentration of 1%-2%, the solid-liquid ratio of chitosan and acetic acid solution is 1g:7-12mL.
5. the preparation method of natural antibacterial agent according to claim 1, it is characterised in that：Supersonic frequency in the step 4)
For 25-35kHz, ultrasonic time 40-50min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711339626.5A CN108125828A (en) | 2017-12-14 | 2017-12-14 | The preparation method of natural antibacterial agent |
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| CN201711339626.5A CN108125828A (en) | 2017-12-14 | 2017-12-14 | The preparation method of natural antibacterial agent |
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| CN108125828A true CN108125828A (en) | 2018-06-08 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674816A (en) * | 2018-12-17 | 2019-04-26 | 东元科技有限公司 | A kind of composite antibacterial aerosol and its preparation method and application |
| CN112519356A (en) * | 2020-11-25 | 2021-03-19 | 上海珂宣尼纺织科技有限公司 | Multifunctional health-care textile and preparation method thereof |
-
2017
- 2017-12-14 CN CN201711339626.5A patent/CN108125828A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674816A (en) * | 2018-12-17 | 2019-04-26 | 东元科技有限公司 | A kind of composite antibacterial aerosol and its preparation method and application |
| CN112519356A (en) * | 2020-11-25 | 2021-03-19 | 上海珂宣尼纺织科技有限公司 | Multifunctional health-care textile and preparation method thereof |
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Application publication date: 20180608 |
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