CN108114227A - 一种治疗胃痛的药物及其制备方法 - Google Patents
一种治疗胃痛的药物及其制备方法 Download PDFInfo
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- CN108114227A CN108114227A CN201711008952.8A CN201711008952A CN108114227A CN 108114227 A CN108114227 A CN 108114227A CN 201711008952 A CN201711008952 A CN 201711008952A CN 108114227 A CN108114227 A CN 108114227A
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Abstract
本发明公开了一种治疗胃痛的药物及其制备方法,它主要是由香茅、荜澄茄、香附、面根藤、砂仁、荜茇、厚朴、香青兰、洋蓍草、神曲、祖师麻、香圆子、扁竹根、金钮头、苦木、枫香树根、刺三甲、岗松根、吴茱萸、豆豉姜、杨梅根、木棉皮、***药、生藤、仙人仗、地不容、红豆蔻、花椒按一定重量配比制备而成,本发明具有温暖脾肾、行气调中、和胃醒脾、理气止痛的功能,用于治疗胃痛见效快,疗效好。
Description
技术领域
本发明涉及一种治疗胃痛的药物及其制备方法,属中药领域。
技术背景
胃痛是以胃脘近心窝处常发生疼痛为主的疾患。中医则认为胃痛与外邪犯胃、素体脾虚、脾胃虚寒有关。由于西药治疗副作用大,因此人们对有效治疗胃痛的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据祖传秘方的基础和临床试验的反复验证,终于研制出有效治疗胃痛的药物,从而完成了本发明。
本发明的目的就是提供一种更有效的治疗胃痛的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择香茅、荜澄茄、香附、面根藤、砂仁、荜茇、厚朴、香青兰、洋蓍草、神曲、祖师麻、香圆子、扁竹根、金钮头、苦木、枫香树根、刺三甲、岗松根、吴茱萸、豆豉姜、杨梅根、木棉皮、***药、三叉虎根、生藤、仙人仗、地不容、红豆蔻、花椒、赤瓟、含羞草、轮叶棘豆进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗胃痛。其中选用香茅是因为其性味辛,温,有疏风解表,祛瘀通络的功能,治感冒头痛,胃痛,泄泻,风湿痹痛,跌打损伤。选用荜澄茄是因为其性味辛,温,入脾、肾经,有温暖脾肾,健胃消食的功能,治食积气胀,脘腹冷痛,反胃呕吐,肠鸣泄泻,痢疾,痰癖。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,***,崩漏带下。选用面根藤是因为其性平,味淡微甜,无毒,治淋病,白带,***,小儿疳积。选用砂仁是因为其性味辛,温,入脾、胃经,有行气调中,和胃、醒脾的功能,治腹痛痞胀,胃呆食滞,噎隔呕吐,寒泻冷痢,妊娠胎动。选用荜茇是因为其性味辛,热,入脾、胃经,有温中,散寒,下气,止痛的功能,治心腹冷痛,呕吐吞酸,肠鸣泄泻,冷痢,阴疝,头痛,鼻渊,齿痛。选用厚朴是因为其性味苦辛,温,入脾、胃、大肠经,有温中,下气,燥湿,消痰的功能,治胸腹痞满胀痛,反胃、呕吐,宿食不消,痰饮喘咳,寒湿泻痢。选用香青兰是因为其有清胃肝热,止血,愈合伤口的功能,治胃肝热,胃出血,食物中毒,赫如虎,巴木病等。选用洋蓍草是因为其性味甘苦辛,性寒,有清热解毒,和血调经的功能,治痈疖肿毒,跌打损伤,痔疮出血,***。选用神曲是因为其性味甘辛,温,入碑、胃经,有健脾和胃,消食调中的功能,治饮食停滞,胸痞腹胀,呕吐泻痢,产后瘀血腹痛,小儿腹大坚积。选用祖师麻是因为其性味辛苦,温,有小毒,有祛风除湿,止痛散瘀的功能,治风湿痹痛,四肢麻木,头痛,胃痛,跌打损伤。选用香圆子是因为其有疏肝、止痛的功能,治疝气、小腹胀痛。选用扁竹根是因为其性味苦,寒,有消食,杀虫,清热,通便的功能,治食积腹胀,蛔虫腹痛,牙痛,喉蛾,大便不通。选用金钮头是因为其性微凉、味淡,有散瘀、消肿、止痛的功能,治劳伤苦伤,跌打肿痛,胃痛。选用苦木是因为其味苦,性寒,归肺、大肠经,有清热,祛湿,解毒的功能,治风热感冒,咽喉肿痛,腹泻下痢,湿疹,疮疖,毒蛇咬伤。选用枫香树根是因为其性味辛苦,性平,无毒,入脾、肾、肝三经,治痈疽,疔疮,风湿关节痛。选用刺三甲是因为其性味苦辛,凉,入肺、肾经,有清热解毒,祛风利湿,舒筋活血的功能,治感冒高热,咳嗽带血,风湿性关节炎,黄疸,白带,***,跌打损伤,疖肿疮疡。选用岗松根是因为其味苦,辛,性寒,归肺,脾,肚经,有祛风除湿,解毒利尿的功能,治感冒发热;风湿痹痛;胃痛;肠炎;黄疸;小便淋痛;脚气;湿疹;虫蛇咬伤。选用吴茱萸是因为其性味辛苦,温,有毒,入肝、胃经,有温中,止痛,理气,燥湿的功能,治呕逆吞酸,厥阴头痛,脏寒吐泻,脘腹胀痛,脚气,疝气,口疮溃疡,齿痛,湿疹,黄水疮。选用豆豉姜是因为其性味辛,温,有祛风除湿,理气止痛的功能,治感冒,风湿痹痛,胃痛,脚气。选用杨梅根是因为其性味辛,温,有理气,止血,化痰的功能,治胃痛,膈食呕吐,疝气,吐血,血崩,痔血,外伤出血,跌打损伤,牙痛,汤火伤,恶疮,疥癞。选用木棉皮是因为其性味辛,平,有清热利湿,活血,消肿的功能,治慢性胃炎,胃溃疡,泄泻,痢疾,腰脚不遂,腿膝疼痛,疮肿,跌打损伤。选用***药是因为其性味辛麻,温,有毒,入肺,心经,有祛风通络,止痛止血的功能,治风湿痛,跌打损伤, 骨折,外伤出血,吐血,衄血,便血。选用三叉虎根是因为其性味苦、性寒,归肝、肺经,有清热解毒、祛风除湿的功能,用于咽喉肿痛,黄疸型肝炎,疮疡肿毒,虫蛇咬伤,风湿骨痛,湿疹,皮炎。选用生藤是因为其性味甘辛,温,有解表温中,祛风通络的功能,治感冒,气管炎,胃痛,痞胀,风湿疼痛。选用仙人仗是因为其性味咸,平,治反胃,吐乳,水肿,脚气,疟疾,痔疮。选用地不容是因为其性味苦、辛,寒,有毒,有清热解毒,消痰,截疟,止痛的功能,治痈疽肿毒,喉闭,疟疾,胃痛。选用红豆蔻是因为其性味辛,温,入手、足太阴经,有散寒,燥湿,消食的功能,治脘腹冷痛,哎吐泄泻,噎膈反胃,疟疾,痢疾。选用花椒是因为其性味辛,温,有毒,入脾、肺、肾经,有温中散寒,除湿,止痛,杀虫,解鱼腥毒,治积食停饮,心腹冷痛,呕吐,噫呃,咳嗽气逆,风寒湿痹,泄泻,痢疾,疝痛,齿痛,蛔虫病,蛲虫病,阴痒,疮疥。选用赤瓟是因为其性味酸苦,平,有降逆,理湿,和瘀的功能,治黄疸,痢疾,反胃吐酸,咳血胸痛,腰部扭伤。选用含羞草是因为其性味甘,寒,有毒,有清热,安神,消积,解毒的功能,治肠炎,胃炎,失眠,小儿疳积,目热肿痛,深部脓肿,带状疱疹。选用轮叶棘豆是因为其性凉,味苦,有小毒,入心,肝经,有止血消炎,止泻镇痛的功能。
具体实施方式
本发明组方的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效
香茅10-20克、荜澄茄3-7克、香附10-20克、面根藤25-35克、砂仁10-20克、荜茇3-7克、厚朴10-20克、香青兰7-12克、洋蓍草7-12克、神曲10-20克、祖师麻3-9克、香圆子3-9克、扁竹根7-12克、金钮头7-12克、苦木7-12克、枫香树根25-35克、刺三甲25-35克、岗松根25-35克、吴茱萸10-15克、豆豉姜10-15克、杨梅根25-35克、木棉皮25-35克、***药3-9克、三叉虎根25-35克、生藤10-20克、仙人仗25-35克、地不容2-4克、红豆蔻7-12克、花椒3-7克、赤瓟7-12克、含羞草7-12克、轮叶棘豆7-12克。
优选为:
香茅15克、荜澄茄5克、香附15克、面根藤30克、砂仁15克、荜茇5克、厚朴15克、香青兰9克、洋蓍草9克、神曲15克、祖师麻6克、香圆子6克、扁竹根9克、金钮头9克、苦木9克、枫香树根30克、刺三甲30克、岗松根30克、吴茱萸12克、豆豉姜12克、杨梅根30克、木棉皮30克、***药6克、三叉虎根30克、生藤15克、仙人仗30克、地不容3克、红豆蔻9克、花椒5克、赤瓟9克、含羞草9克、轮叶棘豆9克。
本发明药物的制备方法如下:
一、备料
1、香茅:全年可采,采得后洗净,晒干;
2、荜澄茄:拣去杂质,摘去果柄,洗净,晒干;
3、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
4、面根藤:8-9月采收;
5、砂仁:拣去杂质及果壳,捣碎;
6、荜茇:拣除杂质,去柄,筛去灰屑,用时捣碎;
7、厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干;
8、香青兰:拣净杂质,晒干;
9、洋蓍草:6-8月采收,割下带有花序的全草,阴干;
10、神曲:取麸皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去麸皮,放凉;
11、祖师麻:全年可采,拣净杂质,晒干;
12、香圆子:10~11月间采收成熟果实,取出种子洗净,晒干;
13、扁竹根:全年可采,洗净,切片晒干;
14、金钮头:拣净杂质,洗净,晒干;
15、苦木:除去杂质,枝洗净,润透,切片,晒干;
16、枫香树根:洗净,晒干;
17、刺三甲:9-10月间挖取,剥取根皮晒干;
18、岗松根:全年均可采挖,洗净,切段,晒干;
19、吴茱萸:取原药材,除去果柄、枝及杂质,筛去碎屑;
20、豆豉姜:9-10月间挖取,洗净,晒干;
21、杨梅根:洗净,晒干;
22、木棉皮:拣净杂质,晒干;
23、***药:拣净杂质,晒干;
24、三叉虎根:全年可采,取根,洗净,切片晒干;
25、生藤:夏、秋采集,切片晒干;
26、仙人仗: 拣净杂质,洗净,晒干;
27、地不容:拣净杂质,晒干;
28、红豆蔻:拣去杂质,筛去灰屑,用时捣碎;
29、花椒:除去果柄及种子椒目,置锅内炒至发响、油出,取出,放凉;
30、赤瓟:果实成熟后连柄摘下,防止果实破裂,用线将果柄串起,挂于日光下或通风处晒干为止;
31、含羞草:夏季采收,晒干。
二、制备
1、将炮制好的香茅、荜澄茄、香附、面根藤、砂仁、荜茇、厚朴、香青兰、洋蓍草、神曲、祖师麻、香圆子、扁竹根、金钮头、苦木、枫香树根、刺三甲、岗松根、吴茱萸、豆豉姜、杨梅根、木棉皮、***药、三叉虎根、生藤、仙人仗、地不容、红豆蔻、花椒、赤瓟、含羞草、轮叶棘豆磨成粗药粉;
2、另取600克水置于煎药容器内,加入上述粗药粉煎煮2个小时,过滤去除药渣,文火煎煮30分钟,再加入炼蜜150克,混合搅拌均匀,再用文火煎煮45分钟撤火,待温,制成梧桐子大小的药丸,置阴凉处阴干即得。
组方中香茅疏风解表,祛瘀通络,荜澄茄有温暖脾肾,健胃消食的功能二者为君药;香附理气解郁,止痛调经,砂仁有行气调中,和胃、醒脾的功能,与面根藤,荜茇,厚朴,香青兰为臣药,八味药共同发挥温暖脾肾、行气调中、和胃醒脾、理气解郁、祛瘀通络的作用,治疗胃痛效力全面,且以清热利湿、散结解毒为主,可治本;金钮头有散瘀、消肿、止痛的功能与洋蓍草,神曲,祖师麻,香圆子,扁竹根,苦木,枫香树根为佐药;豆豉姜有祛风除湿,理气止痛的功能与余下诸药为使药,是治标。
本发明药物具有温暖脾肾、行气调中、和胃醒脾、理气止痛的功能,用于治疗胃痛见效快,疗效好。
以下通过试验例来进一步阐述本发明药物的有益效果,这些试验包括本发明药物的动物毒性试验和临床疗效观察试验。
[试验例1]本发明药物的动物毒性试验
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为0.4g/kg,正常量为0.2g/kg,给药方式为稀释灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治门诊患者共43例。
2、诊断标准
胃痛的症状包括:上腹疼痛发胀、恶心呕吐、消化不良。
3、治疗方法
选用上述药物,给患者服用,每次9克,每天早、晚、午夜各一次,5天为一疗程,连续服用2个疗程。
4、疗效评定标准
显效:胃痛症状消失,恢复正常,痊愈;
好转:患者上腹疼痛发胀、恶心呕吐、消化不良的现象减轻,胃痛症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表):
在上述治疗中,用本发明药物治疗胃痛患者43例,结果显效38例,显效率为88.37%,好转4例,好转率为9.3%,无效1例,总有效率为97.67%。
Claims (3)
1.一种治疗胃痛的药物,其特征在于:它是由下列重量范围内的原料药制成:
香茅10-20克、荜澄茄3-7克、香附10-20克、面根藤25-35克、砂仁10-20克、荜茇3-7克、厚朴10-20克、香青兰7-12克、洋蓍草7-12克、神曲10-20克、祖师麻3-9克、香圆子3-9克、扁竹根7-12克、金钮头7-12克、苦木7-12克、枫香树根25-35克、刺三甲25-35克、岗松根25-35克、吴茱萸10-15克、豆豉姜10-15克、杨梅根25-35克、木棉皮25-35克、***药3-9克、三叉虎根25-35克、生藤10-20克、仙人仗25-35克、地不容2-4克、红豆蔻7-12克、花椒3-7克、赤瓟7-12克、含羞草7-12克、轮叶棘豆7-12克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
香茅15克、荜澄茄5克、香附15克、面根藤30克、砂仁15克、荜茇5克、厚朴15克、香青兰9克、洋蓍草9克、神曲15克、祖师麻6克、香圆子6克、扁竹根9克、金钮头9克、苦木9克、枫香树根30克、刺三甲30克、岗松根30克、吴茱萸12克、豆豉姜12克、杨梅根30克、木棉皮30克、***药6克、三叉虎根30克、生藤15克、仙人仗30克、地不容3克、红豆蔻9克、花椒5克、赤瓟9克、含羞草9克、轮叶棘豆9克。
3.根据权利要求1或2所述药物的制备方法,其特征在于:它包括下列步骤:
(一)备料
(1)香茅:全年可采,采得后洗净,晒干;
(2)荜澄茄:拣去杂质,摘去果柄,洗净,晒干;
(3)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(4)面根藤:8-9月采收;
(5)砂仁:拣去杂质及果壳,捣碎;
(6)荜茇:拣除杂质,去柄,筛去灰屑,用时捣碎;
(7)厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干;
(8)香青兰:拣净杂质,晒干;
(9)洋蓍草:6-8月采收,割下带有花序的全草,阴干;
(10)神曲:取麸皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去麸皮,放凉;
(11)祖师麻:全年可采,拣净杂质,晒干;
(12)香圆子:10~11月间采收成熟果实,取出种子洗净,晒干;
(13)扁竹根:全年可采,洗净,切片晒干;
(14)金钮头:拣净杂质,洗净,晒干;
(15)苦木:除去杂质,枝洗净,润透,切片,晒干;
(16、枫香树根:洗净,晒干;
(17)刺三甲:9-10月间挖取,剥取根皮晒干;
(18)岗松根:全年均可采挖,洗净,切段,晒干;
(19)吴茱萸:取原药材,除去果柄、枝及杂质,筛去碎屑;
(20)豆豉姜:9-10月间挖取,洗净,晒干;
(21)杨梅根:洗净,晒干;
(22)木棉皮:拣净杂质,晒干;
(23)***药:拣净杂质,晒干;
(24)三叉虎根:全年可采,取根,洗净,切片晒干;
(25)生藤:夏、秋采集,切片晒干;
(26)仙人仗: 拣净杂质,洗净,晒干;
(27)地不容:拣净杂质,晒干;
(28)红豆蔻:拣去杂质,筛去灰屑,用时捣碎;
(29)花椒:除去果柄及种子椒目,置锅内炒至发响、油出,取出,放凉;
(30)赤瓟:果实成熟后连柄摘下,防止果实破裂,用线将果柄串起,挂于日光下或通风处晒干为止;
(31)含羞草:夏季采收,晒干;
(二)制备
(1)将炮制好的香茅、荜澄茄、香附、面根藤、砂仁、荜茇、厚朴、香青兰、洋蓍草、神曲、祖师麻、香圆子、扁竹根、金钮头、苦木、枫香树根、刺三甲、岗松根、吴茱萸、豆豉姜、杨梅根、木棉皮、***药、三叉虎根、生藤、仙人仗、地不容、红豆蔻、花椒、赤瓟、含羞草、轮叶棘豆磨成粗药粉;
(2)另取600克水置于煎药容器内,加入上述粗药粉煎煮2个小时,过滤去除药渣,文火煎煮30分钟,再加入炼蜜150克,混合搅拌均匀,再用文火煎煮45分钟撤火,待温,制成梧桐子大小的药丸,置阴凉处阴干即得。
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