CN108114118A - 一种治疗偏头痛的穴位贴 - Google Patents

一种治疗偏头痛的穴位贴 Download PDF

Info

Publication number
CN108114118A
CN108114118A CN201711456070.8A CN201711456070A CN108114118A CN 108114118 A CN108114118 A CN 108114118A CN 201711456070 A CN201711456070 A CN 201711456070A CN 108114118 A CN108114118 A CN 108114118A
Authority
CN
China
Prior art keywords
parts
antimigraine
acupoint plaster
pain
acupoint
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201711456070.8A
Other languages
English (en)
Inventor
司会贞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henan Ming Zhen Fang Pharmaceutical Technology Co Ltd
Original Assignee
Henan Ming Zhen Fang Pharmaceutical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henan Ming Zhen Fang Pharmaceutical Technology Co Ltd filed Critical Henan Ming Zhen Fang Pharmaceutical Technology Co Ltd
Priority to CN201711456070.8A priority Critical patent/CN108114118A/zh
Publication of CN108114118A publication Critical patent/CN108114118A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/754Evodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明公开了一种治疗偏头痛的穴位贴,由以下重量份的原料制成:白芷10‑15份、白芍10‑15份、白芥子10‑15份、川芎10‑15份、郁李仁10‑15份、吴茱萸10‑15份、七叶莲10‑15份、香附8‑12份、柴胡8‑12份、细辛3‑8份。制备方法为:按比例取所有原料,打粉,过150‑200目筛,得混合药粉,装入瓶中备用。本发明采用纯中药制备的穴位贴是经体表皮肤穴位给药,经经络发挥作用,不是胃肠道给药,故不受消化道的吸收、***功能的干扰和影响,同时也不存在损伤脾胃之害,也无伤害肝肾之弊。本发明所得穴位贴具有疏肝解郁、通络止痛的功效,用于治疗偏头痛,而且疗效显著,使用方便,安全可靠,无毒副作用。

Description

一种治疗偏头痛的穴位贴
技术领域
本发明属于医用膏贴技术领域,具体涉及一种治疗偏头痛的穴位贴。
背景技术
偏头痛是反复发作的一种搏动性头痛,属众多头痛类型中的“大户”。发作前常有闪光、视物模糊、肢体麻木等先兆,同时可伴有神经、精神功能障碍。它是一种可逐步恶化的疾病,发病频率通常越来越高。偏头痛约数分钟至一小时左右出现一侧头部一跳一跳的疼痛,并逐渐加剧,直到出现恶心、呕吐后,感觉才会有所好转。在安静、黑暗环境内或睡眠后头痛缓解。在头痛发生前或发作时可伴有神经、精神功能障碍。据研究显示,偏头痛患者比平常人更容易发生大脑局部损伤,进而引发中风。其偏头痛的次数越多,大脑受损伤的区域会越大。
偏头痛主要包括典型性偏头痛、普通型偏头痛和丛集性偏头痛三大类。典型性偏头痛特点是多数病人呈周期性发作,女性多见。发病前大部分病人可出现视物模糊、闪光、幻视、盲点、眼胀、情绪不稳,几乎所有病人都怕光,数分钟后即出现一侧性头痛,大多数以头前部、颞部、眼眶周围、太阳穴等部位为主。可局限某一部位,也可扩延整个半侧,头痛剧烈时可有血管搏动感或眼球跳出感。疼痛一般在1~2 小时达到高峰,持续 4~6小时或十几小时,重者可历时数天,病人头痛难忍十分痛苦。普通型偏头痛占偏头痛患者的80%,比较常见,发病前可没有明显的先兆症状,也有部分病人在发病前有精神障碍、疲劳、哈欠、食欲不振、全身不适等表现,女性月经来潮、饮酒、空腹饥饿时也可诱发疼痛。头痛多呈缓慢加重,疼痛部位可为一侧或双侧,也有的为整个头部,疼痛的程度也较典型性偏头痛轻。丛集性偏头痛的特点是没有先兆症状,每次发作的时间大致相同。头痛常突然开始,持续30~120分钟,在一天内可发生多次,临床表现可出现眼眶发胀、流泪、眼结膜充血、鼻塞、出汗、痛侧颜面部 烧灼感等,典型病例可见头皮血管增粗、弯曲等。此外,偏头痛还包括家族偏瘫性偏头痛、腹痛性偏头痛、神经精神性偏头痛、基底动脉性偏头痛、视网膜性偏头痛和月经期偏头痛等。目前西医只能靠止痛药来缓解疼痛,并无特效药物,而吃止痛药,往往初期有效,吃久了止不住疼痛,或者加大药量,药物的副作用也会随之出现,常见的有胃炎、胃出血、胃溃疡、解热镇痛性肾炎等,甚至会引起药物性头痛。可以说,对于偏头疼,现代西医没有办法治愈。
中医认为偏头痛多为外感、内伤所致,以内伤居多。病位在头,涉及脾肝肾等脏腑,风、火、痰、瘀、虚为致病的主要因素,脉络失养而易致头痛。防治可以用疏散风热、活血止痛、化瘀祛痰、滋阴补血为法,在治疗上,中医中药显示出相当大的优势。穴位贴敷疗法,是民间疗法精华之一,也是祖国医学的重要组成部分。贴敷治病,古谓:“外敷”、“外贴”,故称“贴敷疗法”。因药贴穴位,故又称“穴位贴敷疗法”。它是利用药物贴敷穴位,刺激穴位,而起到药效、穴效的双重作用,达到治病的目的。本疗法独特、简便,可配用不同药物,达到汗、清、下、消、补、温、和等治疗作用。
发明内容
本发明的目的在于克服上述问题,提供一种纯中药制剂、使用方便、疗效显著、无毒副作用,具有疏肝解郁、通络止痛功效的治疗偏头痛的穴位贴。
为实现上述目的,本发明所采用的技术方案具体如下:
一种治疗偏头痛的穴位贴,由以下重量份的原料制成:白芷10-15份、白芍10-15份、白芥子10-15份、川芎10-15份、郁李仁10-15份、吴茱萸10-15份、七叶莲10-15份、香附8-12份、柴胡8-12份、细辛3-8份。
优选的,所述治疗偏头痛的穴位贴由以下重量份的原料制成:白芷12份、白芍12份、白芥子12份、川芎12份、郁李仁12份、吴茱萸12份、七叶莲12份、香附10份、柴胡10份、细辛5份。
所述治疗偏头痛的穴位贴的制备方法为:按比例取所有原料,打粉,过150-200目筛,得混合药粉;取10g混合药粉,加入适量白酒调和成糊状,外敷于患侧太阳穴、内关穴,以胶布固定,敷一夜除去,连敷至愈,一般3-5次痛减,一周痛止。
本发明中药药理作用如下:
白芷:辛、温,归胃、大肠、肺经。具有散风除湿、通窍止痛、消肿排脓的功效,用于治疗感冒头痛、眉棱骨痛、鼻塞、鼻渊、牙痛、白带、疮疡肿痛等症。
白芍:苦、酸、微寒,归肝、脾经。具有平肝止痛、养血调经、敛阴止汗的功效,用于治疗头痛眩晕、胁痛、腹痛、四肢挛痛、血虚萎黄、***、自汗、盗汗等症。
白芥子:辛、温,归肺、胃经。具有利气豁痰、温中散寒、通络止痛的功效,用于治疗痰饮咳喘、胸胁胀满疼痛、反胃呕吐、中风不语、肢体痹痛麻木、脚气、阴疽、肿毒、跌打肿痛等症。
川芎:辛、温,归肝、胆、心包经。具有活血行气、祛风止痛的功效,用于治疗***、经闭痛经、症瘕腹痛、胸胁刺痛、跌扑肿痛、头痛、风湿痹痛等症。
郁李仁:辛、苦、甘、平,归脾、大肠、小肠经。具有润燥滑肠、下气、利水的功效,用于治疗津枯肠燥、食积气滞、腹胀便秘、水肿、脚气、小便不利等症。
吴茱萸:辛、苦、热,归肝、脾、胃、肾经。具有散寒止痛、降逆止呕、助阳止泻的功效,用于治疗厥阴头痛、寒疝腹痛、寒湿脚气、经行腹痛、脘腹胀痛、呕吐吞酸、五更泄泻、等症。
七叶莲:苦、温,归肺、肾、肝、脾四经。具有舒筋活络、行气祛湿、散寒祛风、祛湿止泻的功效,用于治疗跌打损伤、骨折疼痛者、寒湿瘀阻的痛痹、外感风寒、发热畏寒、头身疼痛、脘腹胀满、全身乏力、不思饮食、纳差、痢疾者等症。
香附:辛、微苦、微甘、平,归肝、脾、三焦经。具有行气解郁、调经止痛的功效,用于治疗肝郁气滞、胸/胁/脘腹胀痛、消化不良、胸脘痞闷、寒疝腹痛、***胀痛、***、经闭痛经等症。
柴胡:苦、微寒,归肝、胆经。具有和解表里、疏肝、升阳的功效,用于治疗感冒发热、寒热往来、胸胁胀痛、***、子官脱垂、脱肛等症。
细辛:辛、温,归心、肺、肾经。具有祛风散寒、通窍止痛、温肺化饮的功效,用于治疗风寒感冒、头痛、牙痛、鼻塞鼻渊、风湿痹痛、痰饮喘咳等症。
本发明的有益效果是:
本发明采用纯中药制备的穴位贴是经体表皮肤穴位给药,经经络发挥作用,不是胃肠道给药,故不受消化道的吸收、***功能的干扰和影响,同时也不存在损伤脾胃之害,也无伤害肝肾之弊。本发明所得穴位贴具有疏肝解郁、通络止痛的功效,用于治疗偏头痛,而且疗效显著,使用方便,安全可靠,无毒副作用。
具体实施方式
下面通过具体实施例对本发明作进一步说明。
实施例1
一种治疗偏头痛的穴位贴,由以下重量份的原料制成:白芷10份、白芍10份、白芥子10份、川芎10份、郁李仁10份、吴茱萸10份、七叶莲10份、香附8份、柴胡8份、细辛3份。
所述治疗偏头痛的穴位贴的制备方法为:按比例取所有原料,打粉,过150目筛,得混合药粉;取10g混合药粉,加入适量白酒调和成糊状,外敷于患侧太阳穴、内关穴,以胶布固定,敷一夜除去,连敷至愈,一般3-5次痛减,一周痛止。
实施例2
一种治疗偏头痛的穴位贴,由以下重量份的原料制成:白芷15份、白芍15份、白芥子15份、川芎15份、郁李仁15份、吴茱萸15份、七叶莲15份、香附12份、柴胡12份、细辛8份。
所述治疗偏头痛的穴位贴的制备方法为:按比例取所有原料,打粉,过200目筛,得混合药粉;取10g混合药粉,加入适量白酒调和成糊状,外敷于患侧太阳穴、内关穴,以胶布固定,敷一夜除去,连敷至愈,一般3-5次痛减,一周痛止。
实施例3
一种治疗偏头痛的穴位贴,由以下重量份的原料制成:白芷12份、白芍12份、白芥子12份、川芎12份、郁李仁12份、吴茱萸12份、七叶莲12份、香附10份、柴胡10份、细辛5份。
所述治疗偏头痛的穴位贴的制备方法为:按比例取所有原料,打粉,过180目筛,得混合药粉;取10g混合药粉,加入适量白酒调和成糊状,外敷于患侧太阳穴、内关穴,以胶布固定,敷一夜除去,连敷至愈,一般3-5次痛减,一周痛止。

Claims (3)

1.一种治疗偏头痛的穴位贴,其特征在于,由以下重量份的原料制成:白芷10-15份、白芍10-15份、白芥子10-15份、川芎10-15份、郁李仁10-15份、吴茱萸10-15份、七叶莲10-15份、香附8-12份、柴胡8-12份、细辛3-8份。
2.根据权利要求1所述治疗偏头痛的穴位贴,其特征在于,由以下重量份的原料制成:白芷12份、白芍12份、白芥子12份、川芎12份、郁李仁12份、吴茱萸12份、七叶莲12份、香附10份、柴胡10份、细辛5份。
3.制备权利要求1或2所述治疗偏头痛的穴位贴的方法,其特征在于,按比例取所有原料,打粉,过150-200目筛,得混合药粉;取10g混合药粉,加入适量白酒调和成糊状,备用。
CN201711456070.8A 2017-12-28 2017-12-28 一种治疗偏头痛的穴位贴 Withdrawn CN108114118A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711456070.8A CN108114118A (zh) 2017-12-28 2017-12-28 一种治疗偏头痛的穴位贴

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711456070.8A CN108114118A (zh) 2017-12-28 2017-12-28 一种治疗偏头痛的穴位贴

Publications (1)

Publication Number Publication Date
CN108114118A true CN108114118A (zh) 2018-06-05

Family

ID=62232086

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711456070.8A Withdrawn CN108114118A (zh) 2017-12-28 2017-12-28 一种治疗偏头痛的穴位贴

Country Status (1)

Country Link
CN (1) CN108114118A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846972A (zh) * 2018-12-29 2019-06-07 谭启龙 一种中回药穴位贴敷贴剂及其制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846972A (zh) * 2018-12-29 2019-06-07 谭启龙 一种中回药穴位贴敷贴剂及其制备方法

Similar Documents

Publication Publication Date Title
CN101766773A (zh) 一种治疗足跟痛病的中药配方
CN101301459B (zh) 药枕
CN104984148B (zh) 一种临床用中药伤口护理组合物
CN102139032B (zh) 一种治疗椎间盘突出、骨质增生、类风湿的中药
CN108114118A (zh) 一种治疗偏头痛的穴位贴
CN105561270A (zh) 一种外敷止痛中草药及其制备方法
CN106139099A (zh) 治疗颈肩腰腿痛的中药膏及其制备方法
CN104524107A (zh) 用于风寒湿痹证的中成药
CN101264256B (zh) 治疗顽固性疼痛的中药胶囊
CN104027451B (zh) 一种治疗肝肾不足证型坐骨神经痛的中药
CN102784228A (zh) 一种治疗肘、膝关节创伤性滑膜炎并发积液外用熏洗中药
CN107753688A (zh) 一种治疗骨痛的外敷中药膏及其制备方法
CN106421502A (zh) 用于治疗小儿黄疸的药物组合物
CN106853240A (zh) 一种可有效治疗骨病的外用汤剂药物及其制备方法
CN106420975A (zh) 一种祛除寒痛瘀证的中药
CN105641187A (zh) 一种远红外治疗贴膏
CN105233204A (zh) 阳和通脉中药酒
CN105232799A (zh) 治疗急性痛风的浸浴药液
CN104740193A (zh) 一种治疗颈肩肌肉劳损综合症的中药组合物及其制备方法
CN104547814A (zh) 一种治疗骨与关节结核的中药制剂
CN104689183A (zh) 具有消肿散瘀功效的药酒及制备方法
CN104257972A (zh) 治疗小儿喘息性肺炎的中药
CN103599441A (zh) 一种治疗跌打损伤、骨折、陈旧风湿痛、外伤的中药外用药膏及其制备方法
CN103495150A (zh) 一种解毒生肌浴足粉
CN103768464A (zh) 一种治疗骨髓增生异常综合征的中药组合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20180605

WW01 Invention patent application withdrawn after publication