CN108078884A - A kind of draft emulsifiable paste with Efficient antibacterial and preparation method thereof - Google Patents
A kind of draft emulsifiable paste with Efficient antibacterial and preparation method thereof Download PDFInfo
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- CN108078884A CN108078884A CN201810095586.2A CN201810095586A CN108078884A CN 108078884 A CN108078884 A CN 108078884A CN 201810095586 A CN201810095586 A CN 201810095586A CN 108078884 A CN108078884 A CN 108078884A
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- emulsifiable paste
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of draft emulsifiable pastes with Efficient antibacterial and preparation method thereof, by bateriostatics, herbaceous plant elite and emulsifiable paste matrix composition, 40 60 parts of bateriostatics are wherein included in the emulsifiable paste of 100 parts by weight of enzyme, 20 30 parts of herbaceous plant elite, surplus is emulsifiable paste matrix, and the mass fraction of the bateriostatics is 0.3%, herbaceous plant elite is gradually dissolved in ethanol water according to recipe requirements, emulsifiable paste matrix is heated to 40 60 DEG C afterwards, and add in bateriostatics and the ethanol water of above-mentioned herbaceous plant elite thereto under conditions of stirring, it is all shaken again by ultrasonic wave, and the temperature-resistant of solution is remained during earthquake, it is evaporated concentration, until solution becomes emulsifiable paste shape；While possessing surface layer and penetrating fungistatic effect, additionally it is possible to reduce toxic side effect.
Description
Technical field
The present invention relates to emulsifiable paste technical fields, are specially a kind of draft emulsifiable paste with Efficient antibacterial and preparation method thereof.
Background technology
Skin participates in the activity of body function as first of physiology defence line of human body and maximum organ, moment, ties up
The unity of opposites of body and natural environment is hold, it possesses the Physiological protection function of almost Perfect：Such as barrier action is felt to make
With, adjust body temperature, absorption, secretion and Excretion etc., safeguarding the health of body, playing the role of highly important.So
And skin surface it is parasitic hundreds of microorganisms, have virus, acarid, bacterium, fungi etc., different Tiny ecosystems formed at each position
Environment.Under normal circumstances, these microorganisms are mostly not pathogenic, and only under certain condition, these microorganisms can just invade skin
Skin makes skin molds, 26S Proteasome Structure and Function change, and generates pathologic process, and generates various clinical manifestations accordingly, that is, draws
Send out skin disease.
The skin infection as caused by fungi or bacterium is one of relatively common skin disease.Clinically common antifungal
Object contains hormone, Fungal Skin patient uses dept. of dermatology's external used medicine containing hormone mostly in order to increase antiphlogistic effects
Afterwards, a couple of days thinks that antipruritic effect is also possible that still, and use is further continued for after having spent a couple of days will show disease aggravation
Symptom.
The content of the invention
In order to overcome the shortcomings of prior art, the present invention provide a kind of draft emulsifiable paste with Efficient antibacterial and its
Preparation method, while possessing surface layer and penetrating fungistatic effect, additionally it is possible to reduce toxic side effect, can effectively solve the problem that background skill
The problem of art proposes.
The technical solution adopted by the present invention to solve the technical problems is：
A kind of draft emulsifiable paste with Efficient antibacterial, is made of, wherein enzyme 100 bateriostatics, herbaceous plant elite and emulsifiable paste matrix
Comprising 40-60 parts of bateriostatics, 20-30 parts of herbaceous plant elite in the emulsifiable paste of parts by weight, surplus is emulsifiable paste matrix, and institute
The mass fraction for stating bateriostatics is 0.3%.
As a kind of preferred technical solution of the present invention, the bateriostatics are by citral, kuh-seng, menthol according to mass ratio
3:1:1 composition.
As a kind of preferred technical solution of the present invention, the herbaceous plant elite by Flos Chrysanthemi elite, centella elite,
Aloe elite, honeysuckle elite, fish pelargonium elite and thyme elite are mixed according to arbitrary proportion.
As a kind of preferred technical solution of the present invention, the emulsifiable paste matrix further include excipient, emulsifier, stabilizer and
Preservative, and excipient, emulsifier, the total content of stabilizer and preservative are not more than 15%.
As a kind of preferred technical solution of the present invention, the excipient is by glycerine, liquid vaseline, lanolin and shallow lake
One or more in powder, the emulsifier is by a kind of in polyacrylamide, alkylphenol polyoxyethylene ether and fatty acid ethylene oxide
Or it is a variety of, the stabilizer by, the preservative by the one or more in sodium carboxymethylcellulose, melon bean gum and agar,
The preservative is by chlorhexidine acetate, methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate and propylparaben
One or more.
In addition, as a kind of preferred technical solution of the present invention, the present invention also provides a kind of grass with Efficient antibacterial
The preparation method of the preparation method of this emulsifiable paste, comprises the steps of：
It is water-soluble to be gradually dissolved in ethyl alcohol by the heating for dissolving of S100, herbaceous plant elite according to recipe requirements for herbaceous plant elite
In liquid, and the temperature of ethanol water is controlled as 50-70 DEG C, it is lasting to stir；
Emulsifiable paste matrix is heated to 40-60 DEG C, and is added in thereto under conditions of stirring by the dissolving of S200, emulsifiable paste matrix
The ethanol water of bateriostatics and above-mentioned herbaceous plant elite；
S300, constant-temperature ultrasonic concussion, above-mentioned solvent components are all shaken by ultrasonic wave, and the mistake of earthquake
Remain that the temperature of solution is constant at 50-60 DEG C in journey；
S400, low-temperature evaporation concentration, concentration is evaporated after by ultrasonic oscillation in 50-60 DEG C of temperature range, until
Solution becomes emulsifiable paste shape.
As a kind of preferred technical solution of the present invention, in step S300, the vibration frequency of ultrasonic oscillation is
1.7MHz-2.0MHz, and the operating mode of ultrasonic oscillation using it is intermittent it is reciprocal by the way of, the work of single ultrasonic oscillation
Make the time as 30-60s, intermittent time 5-10s.
As a kind of preferred technical solution of the present invention, in step S400, the pasta specific behaviour of breast is evaporated in solution
Make step：
S401, the foam by the solution removal surface after ultrasonic oscillation, and with stirring rod stirring at low speed by internal foam with
Blistering all removals；
S402, maintain 50-60 DEG C of steady temperature constant, it is colloidal persistently to evaporate moisture to solution, and stopping continues to heat, and
Gradually reduce the temperature of solution；
S403, continue to evaporate the moisture of solution during solution temperature is reduced, solution does not reach after temperature is reduced to room temperature
Continue to air-dry to emulsifiable paste shape, until reaching emulsifiable paste shape.
Compared with prior art, the beneficial effects of the invention are as follows：The present invention improves drug by the bateriostatics of offer
Curative effect with the use of herbaceous plant elite, has significant difference compared with the usual cream that the prior art provides, and is controlling
Skin superficial fungal infection is treated, has the characteristics that cure rate is high, and possesses the effect of deep layer penetrates, due to draft being used to plant
Object, natural component significantly reduce toxic side effect, almost nonirritant to skin, in terms of skin superficial fungal infection is treated
Toxic side effect is substantially reduced.
Description of the drawings
Fig. 1 is the flow diagram of the present invention.
Specific embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other without making creative work
Embodiment belongs to the scope of protection of the invention.
The present invention provides a kind of draft emulsifiable paste with Efficient antibacterial, by bateriostatics, herbaceous plant elite and emulsifiable paste base
Matter forms, and 40-60 parts of bateriostatics, 20-30 parts of herbaceous plant elite, surplus are included wherein in the emulsifiable paste of 100 parts by weight of enzyme
For emulsifiable paste matrix, and the mass fraction of the bateriostatics is 0.3%.
As preferred embodiment, the bateriostatics are by citral, kuh-seng, menthol according to mass ratio 3:1:1 composition；
The herbaceous plant elite is by Flos Chrysanthemi elite, centella elite, aloe elite, honeysuckle elite, fish pelargonium elite and hundred
Essence China mixes according to arbitrary proportion；The emulsifiable paste matrix further includes excipient, emulsifier, stabilizer and preservative, and
Excipient, emulsifier, the total content of stabilizer and preservative are not more than 15%.
In addition, according to above-mentioned, the excipient by one or more in glycerine, liquid vaseline, lanolin and starch,
The emulsifier is by one or more in polyacrylamide, alkylphenol polyoxyethylene ether and fatty acid ethylene oxide, the stabilization
Agent is by the preservative is by the one or more in sodium carboxymethylcellulose, melon bean gum and agar, and the preservative is by acetic acid
One or more in Chlorhexidine, methyl p-hydroxybenzoate, ethyl-para-hydroxybenzoate and propylparaben.
The emulsifiable paste that present embodiment provides, using herbaceous plant elite, can effectively inhibit skin harmful bacteria, have preferable
Permeability, while deep layer harmful bacteria is quickly killed when penetrating skin again can play the role of protect human skin.
In addition, as a kind of preferred technical solution of the present invention, as shown in Figure 1, the present invention also provides one kind to have height
The preparation method of antibacterial draft emulsifiable paste is imitated, is comprised the steps of：
Herbaceous plant elite is gradually dissolved in ethyl alcohol by the step S100, heating for dissolving of herbaceous plant elite according to recipe requirements
In aqueous solution, and the temperature of ethanol water is controlled as 50-70 DEG C, it is lasting to stir；
Emulsifiable paste matrix is heated to 40-60 DEG C by the step S200, dissolving of emulsifiable paste matrix, and under conditions of stirring thereto
Add in bateriostatics and the ethanol water of above-mentioned herbaceous plant elite；
Step S300, constant-temperature ultrasonic shakes, and above-mentioned solvent components are all shaken by ultrasonic wave, and earthquake
During remain that the temperature of solution is constant at 50-60 DEG C；
Step S400, low-temperature evaporation concentrates, and concentration is evaporated in 50-60 DEG C of temperature range after by ultrasonic oscillation,
Until solution becomes emulsifiable paste shape.
Preferably, in step S300, the vibration frequency of ultrasonic oscillation is 1.7MHz-2.0MHz, and ultrasonic wave
The operating mode of concussion using it is intermittent it is reciprocal by the way of, working time of single ultrasonic oscillation is 30-60s, the intermittent time
For 5-10s.
It should be added that in step S400, the pasta concrete operation step of breast is evaporated in solution：
Step S401, by after ultrasonic oscillation solution removal surface foam, and with stirring rod stirring at low speed by inside bubble
Foam and blistering all removals；
Step S402, maintain 50-60 DEG C of steady temperature constant, it is colloidal persistently to evaporate moisture to solution, and stopping continues to add
Heat, and gradually reduce the temperature of solution；
Step S403, the moisture of evaporation solution, solution after temperature is reduced to room temperature are continued during solution temperature is reduced
Not up to emulsifiable paste shape continues to air-dry, until reaching emulsifiable paste shape.
Due to directly evaporating under the high temperature conditions, it will emulsifiable paste is caused persistently to be evaporated when being cooled to room temperature, it will eventually
Become to be dried to bulk, will be unable to use, but also pharmaceutical component can be destroyed, therefore can only cool down in advance, when being cooled to room
After temperature, if the drying regime for being not reaching to requirement, which need to only continue to air-dry, can reach corresponding requirement.
It further illustrates, the application method of emulsifiable paste provided by the invention：After cleaning skin disease is dried, appropriate sheet is taken
Product are applied to required position and surrounding and suitably gently rub a moment, until skin fully absorbs.
In conclusion the main characteristic of the invention lies in that：
（1）The present invention is by the bateriostatics of offer, the effect of improving drug, with the use of herbaceous plant elite, with existing skill
The usual cream that art provides, which is compared, has significant difference, and is treating skin superficial fungal infection, high with cure rate
Feature, and possess the effect of deep layer penetrates；
(2) due to using herbaceous plant, natural component significantly reduces toxic side effect, almost nonirritant to skin, is controlling
Toxic side effect in terms for the treatment of skin superficial fungal infection is substantially reduced.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requirement rather than above description limit, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.Any reference numeral in claim should not be considered as to the involved claim of limitation.
Claims (8)
1. a kind of draft emulsifiable paste with Efficient antibacterial, which is characterized in that by bateriostatics, herbaceous plant elite and emulsifiable paste matrix group
Into comprising 40-60 parts of bateriostatics, 20-30 parts of herbaceous plant elite wherein in the emulsifiable paste of 100 parts by weight of enzyme, surplus is breast
Cream base matter, and the mass fraction of the bateriostatics is 0.3%.
2. a kind of draft emulsifiable paste with Efficient antibacterial according to claim 1, which is characterized in that the bateriostatics are by lemon
Lemon aldehyde, kuh-seng, menthol are according to mass ratio 3:1:1 composition.
A kind of 3. draft emulsifiable paste with Efficient antibacterial according to claim 1, which is characterized in that the herbaceous plant essence
China is by Flos Chrysanthemi elite, centella elite, aloe elite, honeysuckle elite, fish pelargonium elite and thyme elite according to arbitrary
Ratio mixes.
4. a kind of draft emulsifiable paste with Efficient antibacterial according to claim 1, which is characterized in that the emulsifiable paste matrix is also
Including excipient, emulsifier, stabilizer and preservative, and excipient, emulsifier, the total content of stabilizer and preservative are not more than
15%。
5. a kind of draft emulsifiable paste with Efficient antibacterial according to claim 4, which is characterized in that the excipient is by third
One or more in triol, liquid vaseline, lanolin and starch, the emulsifier is by polyacrylamide, alkyl phenol polyoxy second
One or more in alkene ether and fatty acid ethylene oxide, the stabilizer is by the preservative is by sodium carboxymethylcellulose, melon
One or more in bean gum and agar, the preservative is by chlorhexidine acetate, methyl p-hydroxybenzoate, P-hydroxybenzoic acid
One or more in ethyl ester and propylparaben.
6. a kind of draft emulsifiable paste with Efficient antibacterial according to claim 1, which is characterized in that further include its preparation side
Method comprises the steps of：
It is water-soluble to be gradually dissolved in ethyl alcohol by the heating for dissolving of S100, herbaceous plant elite according to recipe requirements for herbaceous plant elite
In liquid, and the temperature of ethanol water is controlled as 50-70 DEG C, it is lasting to stir；
Emulsifiable paste matrix is heated to 40-60 DEG C, and is added in thereto under conditions of stirring by the dissolving of S200, emulsifiable paste matrix
The ethanol water of bateriostatics and above-mentioned herbaceous plant elite；
S300, constant-temperature ultrasonic concussion, above-mentioned solvent components are all shaken by ultrasonic wave, and the mistake of earthquake
Remain that the temperature of solution is constant at 50-60 DEG C in journey；
S400, low-temperature evaporation concentration, concentration is evaporated after by ultrasonic oscillation in 50-60 DEG C of temperature range, until
Solution becomes emulsifiable paste shape.
7. the preparation method of a kind of draft emulsifiable paste with Efficient antibacterial according to claim 6, which is characterized in that in step
In rapid S300, the vibration frequency of ultrasonic oscillation is 1.7MHz-2.0MHz, and the operating mode of ultrasonic oscillation is using interval
The reciprocal mode of formula, the working time of single ultrasonic oscillation is 30-60s, intermittent time 5-10s.
8. the preparation method of a kind of draft emulsifiable paste with Efficient antibacterial according to claim 6, which is characterized in that in step
In rapid S400, the pasta concrete operation step of breast is evaporated in solution：
S401, the foam by the solution removal surface after ultrasonic oscillation, and with stirring rod stirring at low speed by internal foam with
Blistering all removals；
S402, maintain 50-60 DEG C of steady temperature constant, it is colloidal persistently to evaporate moisture to solution, and stopping continues to heat, and
Gradually reduce the temperature of solution；
S403, continue to evaporate the moisture of solution during solution temperature is reduced, solution does not reach after temperature is reduced to room temperature
Continue to air-dry to emulsifiable paste shape, until reaching emulsifiable paste shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810095586.2A CN108078884A (en) | 2018-01-31 | 2018-01-31 | A kind of draft emulsifiable paste with Efficient antibacterial and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810095586.2A CN108078884A (en) | 2018-01-31 | 2018-01-31 | A kind of draft emulsifiable paste with Efficient antibacterial and preparation method thereof |
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| Publication Number | Publication Date |
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| CN108078884A true CN108078884A (en) | 2018-05-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810095586.2A Pending CN108078884A (en) | 2018-01-31 | 2018-01-31 | A kind of draft emulsifiable paste with Efficient antibacterial and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104056218A (en) * | 2014-06-09 | 2014-09-24 | 韩龙龙 | Medicine for treating skin diseases and preparation method of medicine |
| CN104510653A (en) * | 2013-09-27 | 2015-04-15 | 青岛畅绿生物研究所 | Antibacterial and nourishing water-lily massage water for baby |
| CN104856899A (en) * | 2015-05-14 | 2015-08-26 | 青岛国航祥玉技术服务有限公司 | Herbal hand sanitizer |
| CN105641158A (en) * | 2016-01-23 | 2016-06-08 | 河北康正药业有限公司 | Formula for treating dermatosis |
-
2018
- 2018-01-31 CN CN201810095586.2A patent/CN108078884A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510653A (en) * | 2013-09-27 | 2015-04-15 | 青岛畅绿生物研究所 | Antibacterial and nourishing water-lily massage water for baby |
| CN104056218A (en) * | 2014-06-09 | 2014-09-24 | 韩龙龙 | Medicine for treating skin diseases and preparation method of medicine |
| CN104856899A (en) * | 2015-05-14 | 2015-08-26 | 青岛国航祥玉技术服务有限公司 | Herbal hand sanitizer |
| CN105641158A (en) * | 2016-01-23 | 2016-06-08 | 河北康正药业有限公司 | Formula for treating dermatosis |
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