CN108066518A - 一种犬用中药浴液组合物及其制备方法 - Google Patents
一种犬用中药浴液组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种犬用中药浴液组合物及其制备方法,包括以下重量份的中草药原料中的各组分:苦参10‑15份,蝉蜕3‑5份,杏仁6‑10份,艾草20‑30份,蛇床子10‑15份,白花蛇舌草5‑8份,连翘5‑6份,薄荷10‑15份,芦荟10‑15份,蜂胶3‑5份。本发明选用各种中药组分,相较于一些西药或激素类药物毒副作用小,杀虫、杀菌范围广,且不易导致治病菌、寄生虫产生耐药性,本发明通过药浴的方式进行治疗,不经胃肠破坏,而是直接作用于皮肤,将药效作用于全身肌表及患处,较内服药疗效快,无任何副作用,也不会增加肝脏负担。
Description
技术领域
本发明属于动物疾病防治技术领域,具体涉及一种犬用中药浴液组合物及其制备方 法。
背景技术
犬类表面毛发较长,经常在地面、草丛等病菌、寄生虫较多的地方打滚,毛发清洗不 勤等,容易感染犬脓皮病、皮肤真菌感染与外寄生虫感染等皮肤疾病。
犬脓皮病是一种当伴有细菌感染时,真皮层以及皮下组织坏死形成脓枝汁的皮肤炎症, 而不同于渗出性或化脓性表面皮炎,其分为脓疱疮、疖和舐嗜性肉芽肿等几种。脓疱疮是 由葡萄球菌、链球菌感染所致表皮层内形成脓疱、小水疱等病理变化,多见于犬的腹部, 细小而呈白色,有时有脓汁渗出并干燥形成结痂,有的犬可在口和足周围见到,体弱小犬 更易发病,治疗可在清创后涂擦碘酒或渗透性较好的抗菌药物,较大面积的炎症,需全身 使用抗菌素。疖是一种深部毛囊脓肿,通常伴有真皮或皮下脓肿,有的则破溃流出脓血,疖比较常见于有粗硬毛的犬,如杜伯文和大丹犬等,在犬体经常受压和摩擦的区域,如胸侧、四肢,尤其是骨骼突起的部位多发疖,后期可因周团组织角化过度形成胼胝脓性病, 而破损的毛囊则成为脓茬。舐嗜性肉芽肿是由于犬的不断舐咬而致的慢性皮肤溃疡,多继 发于先前的炎症或瘙痒,主要临床变化是:创部红肿、脱毛,组织渗出及惰性上皮边缘, 早期较小的溃疡面,可局部使用皮质激素类药物。给犬戴口罩以避免犬不断的舐嗜,使用 冷冻疗法破坏敏感的神经末梢和过度增生的肉芽组织,以促进创面愈合,增加犬的活动, 可减少犬的舐嗜。
癣病是一种常见的真菌感染皮肤病,多发于犬的脸部、躯干、四肢和尾部等处,出现 圆形或者椭圆形的癣斑,上面覆有灰色的鳞屑,用紫外线灯照射可见紫色的荧光点。患病 犬的毛色会变得粗糙,癣斑部分的皮毛一撮一撮脱落折断或者脱落,被传染的犬会感到奇 痒无比而去反复抓挠,所以患病部位会形成斑秃。癣病还会传染给人类,造成人皮肤瘙痒、 脱皮。癣病多见于营养不良和体弱多病的犬类,增加营养特别是B族维生素的摄入,有利于预防该病和已染病动物的恢复。感染犬的真菌有2种,即犬小孢子菌和须毛癣菌,98%是犬小孢子菌,随着病的演变,成为有刺激性的干燥圆形斑疹(金钱癣)。现阶段对于犬 癣病的治疗主要为灰黄霉素、克霉唑等抗真菌药物,但是,由于孢子对热和消毒药液的抵 抗力强,不易将其杀死,因此一旦发生本病,不易彻底治疗。
犬螨虫又叫犬疥癣,是常见的犬类外寄生虫感染病,俗称“癞皮狗病”,是由疥螨或犬 耳痒螨寄生所致,多发于8、9月及冬季,常见于卫生条件和饲养通风条件很差的犬,镜检可见活的虫体。犬螨病多发生于头、颈、尾部,幼犬症状严重,先发生于鼻梁、颊部、 耳根及腋间等处,然后扩散至全身,起初皮肤发红,出现红色小结节,以后变成水泡,水 泡破溃后,流出粘稠黄色油状渗出物,渗出物干燥后形成鱼鳞状痂皮,患部剧痒,病犬常 以爪抓挠患部或其他物体上摩擦,因而出现严重脱毛。若继发感染后可出现小脓疱,随着 病情的继续发展,病变部位不断扩大,可能蔓延到全身。由于螨分泌毒素的刺激,其病变 特征为患犬发生剧烈的痒觉,病变部位结节、痂快、掉毛,引起犬只消瘦、行动不便、甚 至死亡。该病由于虫体的寄生部位较为特殊,传播速度快,预防和治疗就显得更加的困难, 严重影响宠物的生长、发育、生产等,对宠物犬、猫的养殖业造成了巨大的危害,同时, 由于疥螨可以感染人类,宠物犬、猫螨病会给养殖者带来潜在的危害和感染,影响人类健 康。目前,药治疗使用伊维菌素(害获灭)1%浓度,0.5-1毫克/千克体重,背部皮下注射, 隔6-7月一次,2-3次为一疗程。目前单独使用西药治疗,效果并不确切,并且,病犬喜欢 磨蹭皮肤,导致皮肤损伤,继发细菌感染,且疾病反复发作,而且痒感无法消除。
综合上述,对于由细菌、真菌、寄生虫等原因造成的犬类皮肤疾病,目前多采用一些 西药甚至激素类药物,其效果不确切且往往不能根治,容易造成犬类皮肤疾病反复发作。 并且,当这些皮肤疾病病发时往往已经造成了一定程度的传染,形成了较大的危害。目前, 犬类疾病预防和治疗中对于中药的利用较少,而利用我国丰富的中草药资源研发出适合预 防和治疗犬类皮肤疾病的中药制剂,从来控制犬类皮肤疾病的发病几率,将为犬类皮肤疾 病的临床治疗提供新的思路,同时也具有非常广阔的市场前景。
发明内容
针对现有技术的不足,本发明通过提供一种犬用中药浴液组合物及其制备方法,其能 够预防和治疗多种犬类皮肤疾病,降低犬类皮肤疾病的发病几率,且防止疾病治愈后反复 发作。
为实现上述目的,本发明的技术方案为一种犬用中药浴液组合物及其制备方法,包括 以下重量份的中草药原料中的各组分:苦参10-15份,蝉蜕3-5份,杏仁6-10份,艾草20-30 份,蛇床子10-15份,白花蛇舌草5-8份,连翘5-6份,薄荷10-15份,芦荟10-15份,蜂胶3-5份。
优选的,还包括黄花蒿6-8份。
优选的,还包括大蒜蒜瓣10-13份。
优选的,还包括青盐2-3份。
优选的,还包括精油0.5-2份;所述精油为柠檬草精油、香榧精油、茶树精油的一种或多种。
所述精油为柠檬草精油、香榧精油、茶树精油按照重量比1:2:1.5混合而成。
本发明还提供了所述的犬用中药浴液组合物的制备方法,包括以下步骤:
(1)原料处理:将苦参、杏仁、薄荷、芦荟、蜂胶、黄花蒿、大蒜蒜瓣以及艾草分 别进行烘干,粉碎后过筛,然后加入青盐后充分混匀,得混合物;
(2)水浸提:将步骤(1)所得的混合物加水后加热,超声波辅助作用下进行浸提,浸提结束后,过滤得滤液I;滤渣加水按照同样的方法进行超声波辅助浸提、过滤,重复 2-3次,得滤液II;合并滤液I、滤液II即得水浸提液;
(3)超声逆流提取:向步骤(2)所得的浸提滤渣中加入55-60%乙醇,超声波辅助作用下逆流提取,过滤得提取液I;滤渣加等重量的55-60%乙醇按照同样的方法进行超声波辅助逆流提取、过滤,重复1-2次,得提取液II;合并提取液I、提取液II即得逆流提 取液;
(4)水煎煮提取:取蝉蜕、蛇床子、白花蛇舌草以及连翘,加5-8倍重量的水浸泡 1-2h,然后武火煮开,转文火煎1.5-2h后,过滤,收集煎煮液I;药渣加2-4倍重量的水武 火煮开,转文火煎0.5-1h后,过滤,收集煎煮液II;合并煎煮液I、煎煮液II即得水煎煮 液;
(5)混合、浓缩:待步骤(4)制备的水煎煮液冷却至50℃以下,加入步骤(2)制 备的水浸提液以及步骤(3)制备的逆流提取液混合均匀,然后低温蒸发浓缩得中药稠液;
(6)消毒灭菌:将步骤(5)制备的中药稠液消毒灭菌,加入精油混合后,经无菌装袋或罐装后即得成品。
优选的,步骤(1)中,烘干温度为35-50℃,烘干时间为12-24h;粉碎后过60目筛;步骤(2)中,所述混合物与水按照质量体积比为1:3-5的固液比混合,然后加热至40-50℃,在700-900W超声波辅助作用下,浸提20-30min,浸提结束后,1-3层的80-100目纱布过 滤得滤液I;所述滤渣与水按照质量体积比为1:2-3的固液比混合。
优选的,步骤(3)中,所述浸提滤渣与55-60%乙醇按照质量体积比为1:2-3的固液比混合,在1000-1200W超声波辅助作用下逆流提取50-80min后,1-3层的80-100目纱布 过滤得提取液I。
优选的,步骤(5)中,低温蒸发的温度为40-45℃;步骤(6)中,所述消毒灭菌方 式为紫外线消毒灭菌或20KGy60Co消毒灭菌中的一种。
本发明中,各原料的功效如下:
苦参味苦,性寒。归心、肝、胃、大肠、膀胱经。为豆科植物苦参的干燥根。具有清 热燥湿,杀虫止痒、局部抗菌消炎作用,用于热痢,便血。黄疸尿闭,赤白带下,阴肿阴 痒,湿疹,湿疮,皮肤瘙痒,疥癣麻风;外治滴虫性***炎。
蝉蜕味甘,性寒。归肺、肝经。为蝉科昆虫黑蚱的若虫羽化时脱落的皮壳。具有散风除热,利咽,透疹,退翳,解痉的功效。用于风热感冒,咽痛,音哑,麻疹不透,风疹瘙 痒,目赤荞障,惊风抽搐,破伤风。
(生)杏仁苦,微温。苦杏仁苷具有抗突变作用,能减少由安乃近、灭滴灵、丝裂霉素C等引起的微核多染性红细胞的数量。杏仁油还有驱虫、杀菌作用,体外试验对人蛔 虫、蚯蚓有杀死作用,并对伤寒、副伤寒杆菌有抗菌作用。杏仁还具有抗蛲虫和滴虫感染, 治疗再生障碍性贫血作用。
艾草性味苦、辛、温,入脾、肝、肾,有调经止血﹑安胎止崩﹑散寒除湿之效。现代 实验研究证明,艾叶具有抗菌及抗病毒作用;止血及抗凝血作用;镇静及抗过敏作用;护 肝利胆作用等。艾草具有一种特殊的香味,这特殊的香味具有驱蚊虫的功效,所以,古人 常在门前挂艾草,一来用于避邪,二来用于赶走蚊虫。现代药理发现,艾叶挥发油含量多, 1.8-桉叶素(占50%以上),其它有α-侧柏酮、倍半萜烯醇及其酯。风干叶含矿物质10.13%, 脂肪2.59%,蛋白质25.85%,以及维生素A、B1、B2、C等。
蛇床子为伞形科植物蛇床的干燥成熟果实,辛、苦,温,有小毒,具有燥湿,祛风,杀虫,止痒,温肾壮阳之功效。
白花蛇舌草,其成药味苦、淡,性寒。主要功效是清热解毒、消痛散结、利尿除湿。尤善治疗各种类型炎症,对疖肿疮疡有着很好的治疗效果。在临床实践中,发现白花蛇舌草若配伍得当,可治疗多种疾病。
连翘性凉,味苦,无毒。主要功效是清热,解毒,散结,消肿。治温热,丹毒,斑疹, 痈疡肿毒,瘰疬,小便淋闭。
薄荷是辛凉性发汗解热药,治流行性感冒、头疼、目赤、身热、咽喉、牙床肿痛等症。外用可治神经痛、皮肤瘙痒、皮疹和湿疹等。
芦荟性味苦、寒。主要功效是泻火、解毒、化瘀、杀虫。主目赤、便秘、白浊、尿血、 小儿惊痫、疳积、烧烫伤、妇女闭经、痔疮、疥疮、痈疖肿毒、跌打损伤。现代药理发现, 其具有良好的杀菌作用,抗炎作用,湿润美容作用,健胃下泄作用,强心活血作用,免疫 和再生作用,免疫与抗肿瘤作用,解毒作用,抗衰老作用,镇痛、镇静作用,防晒作用。
蜂胶其性平,味苦、辛、微甘,有润肤生肌,消炎止痛的功效,可治疗胃溃疡、口腔溃疡、烧烫伤、皮肤裂痛,防辐射等症状。其内服补虚弱、化浊脂、止消渴;外用解毒消 肿。内服用于体虚早衰、高脂血症、消渴;外治用于皮肤皲裂、烧烫伤。蜂胶内含20大 类共300余种营养成分。蜂胶的成分中,最具代表性的活性物质是黄酮类化合物中的槲皮 素、萜类及有机酸中的咖啡酸苯乙酯,除黄酮类化合物外,蜂胶还有丰富的氨基酸,微生 物,香挥发油,烯萜类化合物,有机酸类,黄烷醇类,醇、酚、醛、酮、酯、醚类化合物, 酶类及无机盐等,犹如一个天然的“药库”。
黄花蒿性味辛苦,凉,无毒,寒。主要功效为清热解疟,驱风止痒,其叶汁能够涂恶疮疥癣及毒虫咬伤。黄花蒿入药,作清热、解暑、截疟、凉血用,还作外用药,亦可用作 香料、牲畜饲料。黄花蒿含挥发油,并含青蒿素、黄酮类化合物等。黄花蒿中的青蒿素, 为抗疟的主要有效成分。
大蒜性味温,辛、甘。能够散痈肿魇疮,除风邪,杀毒气。其主要功效为解毒杀虫,消肿止痛,止泻止痢,治肺,驱虫,此外,还有温脾暖胃,大蒜能够治痈疽肿毒,白秃癣 疮,痢疾泄泻,肺痨顿咳,蛔虫蛲虫,饮食积滞,脘腹冷痛,水肿胀满,行气消积,杀虫 解毒。大蒜中含硫化合物(三硫二丙烯,又名蒜素、大蒜油)具有奇强的抗菌消炎作用, 对多种球菌、杆菌、真菌和病毒等均有抑制和杀灭作用,是当前发现的天然植物中抗菌作 用最强的一种。
青盐,性味:咸、寒,具有凉血、明目之功效,用于治疗吐血、衄血、尿血,外治目 赤肿痛、牙痛等症状。青盐又称“湖盐”、“岩盐”,味咸,化学成分为氯化钠,往往混有 粘土以及钙、镁氯化物等,具有很好的杀菌作用。
柠檬草精油是提取自柠檬草的一种精油,有非常好的抗沮丧、抗菌、杀菌、祛肠胃胀 气、除臭、帮助消化、利尿、杀霉菌、催乳、杀昆虫、预防疾病、激励、补身等功效。它 能够有效驱虫,使动物身上的跳蚤、害虫远离,而除臭功能可让动物保持好气味。
香榧精油对真菌的抑制效果要比对细菌好,研究发现其细菌的抑制作用存在时效性, 48h左右会出现最大抑制效果。并且,动物实验表明,香榧精油对白纹伊蚊具有很好的驱 避效果,可作为驱蚊剂;而香榧的乙醇提取物和玫瑰根部提取物一样,具有消炎作用,证实了中国民间药用香榧消炎镇痛的说法。
茶树精油能有效对抗多种细菌,有研究表明,0.25%浓度的茶树精油即能抑制90%的 大肠杆菌,0.5%浓度的茶树精油即可抑制金黄色葡萄球菌的繁殖,甚至连对各种抗生素已 经产生抗药性的超级细菌:抗甲氧苯青霉素性金黄色葡萄酒都能杀灭。
与现有技术先比,本发明的有益技术效果:
(1)本发明的犬用中药浴液组合物,不仅仅将有相关功效的中药原料简单地混合,而是结合其药用机理,使中药各组分进行协同增效,从而发挥最大的药效。本发明具有抑菌抗炎、清热散毒的功效,相较于西药专药专用,仅能治疗某一方面的皮肤疾病,且容易 复发,本发明制备的中药浴液组合物药用广泛,能够有效地治疗由细菌、真菌和寄生虫引 起犬传染性皮肤病,治疗效果显著且不易复发。
(2)对于健康的犬类,通过降低本发明中药浴液组合物的浓度(即增大稀释倍数)亦可起到很好的预防效果。
(3)本发明所选用药物,均有滋润肌肤、清热解毒、祛风止痒的功效,药浴时,水 温可使毛窍开放,从而作用到表皮甚至真皮下的病灶部位,加之开放的毛孔能使药物的有 效成分更容易的进入体内,因此,药用效果较为明显、迅速,能够根治犬类各种皮肤传染 疾病。而且,犬类药浴或者淋浴后,其病发部位不会感到瘙痒,因此犬类不会因过于瘙痒 或疼痛频繁抓挠病灶部位,从而避免了病灶部位更加严重,减轻了犬类的痛苦,加快了治 疗过程。
(4)本发明中的精油不仅能够遮蔽药物的气味,提供清新的香气;并且将柠檬草精油、香榧精油、茶树精油按照一定比例组成复合精油,三者具有协同作用,使本发明的药 物预防和治疗效果更好。
(5)本发明在制备过程中,通过对不同中药原料采用不同的处理和提取方式,使各中药原料中的目的成分充分的提取出来,且在某些干燥、提取、浓缩以及消毒等过程中, 均控制温度,使一些药用成分保持活性成分的状态,从而保证治疗效果显著。
(6)本发明相较于内服药见效快,相较于皮肤涂抹用乳膏不易将全部病灶部位涂抹 (有些发病部位肉眼不可见),能够作用于所有皮肤病灶部位。
综合上述,本发明选用各种中药组分,相较于一些西药或激素类药物毒副作用小,杀 虫、杀菌范围广,且不易导致治病菌、寄生虫产生耐药性,本发明通过药浴的方式进行治疗,不经胃肠破坏,而是直接作用于皮肤,将药效作用于全身肌表及患处,较内服药疗效快,无任何副作用,也不会增加肝脏负担。并且还能够改善皮肤新陈代谢,促进血液循环,杀灭病毒,消除细菌,增强抗病能力,使皮肤柔软光泽,富有弹性,治疗后不易复发,对 于健康的犬类有很好的预防效果。
具体实施方式
下面根据具体实施方式对本发明作进一步详细的说明。
实施例1
一种犬用中药浴液组合物及其制备方法,包括以下中草药原料中的各组分:苦参,蝉 蜕,杏仁,艾草,蛇床子,白花蛇舌草,连翘,薄荷,芦荟,蜂胶,黄花蒿,还包括大蒜 蒜瓣,青盐,柠檬草精油。中草药原料中各组分的具体配比如表1所示。
一种犬用中药浴液组合物的制备方法,包括以下步骤:
(1)原料处理:将苦参、杏仁、薄荷、芦荟、蜂胶、黄花蒿、大蒜蒜瓣以及艾草分 别进行35℃烘干12h,粉碎后过筛,然后加入青盐后充分混匀,得混合物。
(2)水浸提:将步骤(1)所得的混合物与水按照质量体积比为1:3的固液比混合,然后加热至40℃,在700W超声波辅助作用下,浸提20min,浸提结束后,单层的80-100 目纱布过滤得滤液I;所述滤渣与水按照质量体积比为1:2的固液比混合,按照同样的方法 进行超声波辅助浸提、过滤,重复2次,得滤液II;合并滤液I、滤液II即得水浸提液。
(3)超声逆流提取:向步骤(2)所得的浸提滤渣与55%乙醇按照质量体积比为1:2的固液比混合,在1000W超声波辅助作用下逆流提取50min后,单层的80目纱布过滤得 提取液I;滤渣加等重量的55%乙醇按照同样的方法进行超声波辅助逆流提取、过滤,重 复1次,得提取液II;合并提取液I、提取液II即得逆流提取液。
(4)水煎煮提取:取蝉蜕、蛇床子、白花蛇舌草以及连翘加5倍重量的水浸泡1h, 然后武火煮开,转文火煎1.5h后,过滤,收集煎煮液I;药渣加2倍重量的水武火煮开, 转文火煎0.5h后,过滤,收集煎煮液II;合并煎煮液I、煎煮液II即得水煎煮液。
(5)混合、浓缩:待步骤(4)制备的水煎煮液冷却至50℃以下,加入步骤(2)制 备的水浸提液以及步骤(3)制备的逆流提取液混合均匀,然后在40℃条件下低温蒸发浓 缩得中药稠液。
(6)消毒灭菌:将步骤(5)制备的中药稠液采用紫外线消毒灭菌,加入柠檬草精油混合后,经无菌装袋或罐装后即得300g成品。
由该方法制备的犬用中药浴液组合物在使用时,按照药液:水(水温不易超过60℃, 以防药物中活性成分失活,降低药效)为1:100-3000的体积比混合(预防浓度偏低即可, 治疗浓度偏大)后,为宠物犬喷浴或者淋浴皆可,浸泡或者淋浴后,是否用清水清洗均可, 因为有精油气味的遮盖,即使不用清水清洗药味也不明显,并且预防和治疗效果更加持久。
实施例2
一种犬用中药浴液组合物及其制备方法,包括以下中草药原料中的各组分:苦参,蝉 蜕,杏仁,艾草,蛇床子,白花蛇舌草,连翘,薄荷,芦荟,蜂胶,黄花蒿,还包括大蒜 蒜瓣,青盐,香榧精油。中草药原料中各组分的具体配比如表1所示。
一种犬用中药浴液组合物的制备方法,包括以下步骤:
(1)原料处理:将苦参、杏仁、薄荷、芦荟、蜂胶、黄花蒿、大蒜蒜瓣以及艾草分 别进行50℃烘干24h,粉碎后过筛,然后加入青盐后充分混匀,得混合物。
(2)水浸提:将步骤(1)所得的混合物与水按照质量体积比为1:5的固液比混合,然后加热至50℃,在900W超声波辅助作用下,浸提30min,浸提结束后,3层的100目 纱布过滤得滤液I;所述滤渣与水按照质量体积比为1:3的固液比混合,按照同样的方法进 行超声波辅助浸提、过滤,重复3次,得滤液II;合并滤液I、滤液II即得水浸提液。
(3)超声逆流提取:向步骤(2)所得的浸提滤渣与55-60%乙醇按照质量体积比为1:3的固液比混合,在1200W超声波辅助作用下逆流提取80min后,3层的100目纱布过 滤得提取液I;滤渣加等重量的60%乙醇按照同样的方法进行超声波辅助逆流提取、过滤, 重复2次,得提取液II;合并提取液I、提取液II即得逆流提取液。
(4)水煎煮提取:取蝉蜕、蛇床子、白花蛇舌草以及连翘加8倍重量的水浸泡2h, 然后武火煮开,转文火煎2h后,过滤,收集煎煮液I;药渣加4倍重量的水武火煮开,转 文火煎1h后,过滤,收集煎煮液II;合并煎煮液I、煎煮液II即得水煎煮液。
(5)混合、浓缩:待步骤(4)制备的水煎煮液冷却至50℃以下,加入步骤(2)制 备的水浸提液以及步骤(3)制备的逆流提取液混合均匀,然后在45℃条件下低温蒸发浓 缩得中药稠液。
(6)消毒灭菌:将步骤(5)制备的中药稠液采用20KGy60Co消毒灭菌,加入香榧 精油混合后,经无菌装袋或罐装后即得300g成品。
由该方法制备的犬用中药浴液组合物在使用时,按照药液:水(水温不易超过60℃, 以防药物中活性成分失活,降低药效)为1:300-2000的体积比(预防浓度偏低即可,治疗 浓度偏大)混合后,为宠物犬喷浴或者淋浴皆可,浸泡或者淋浴后,是否用清水清洗均可, 因为有精油气味的遮盖,即使不用清水清洗药味也不明显,并且预防和治疗效果更加持久。
实施例3
一种犬用中药浴液组合物及其制备方法,包括以下中草药原料中的各组分:苦参,蝉 蜕,杏仁,艾草,蛇床子,白花蛇舌草,连翘,薄荷,芦荟,蜂胶,黄花蒿,还包括大蒜 蒜瓣,青盐,茶树精油。中草药原料中各组分的具体配比如表1所示。
一种犬用中药浴液组合物的制备方法,包括以下步骤:
(1)原料处理:将苦参、杏仁、薄荷、芦荟、蜂胶、黄花蒿、大蒜蒜瓣以及艾草分 别进行40℃烘干16h,粉碎后过筛,然后加入青盐后充分混匀,得混合物。
(2)水浸提:将步骤(1)所得的混合物与水按照质量体积比为1:4的固液比混合,然后加热至45℃,在800W超声波辅助作用下,浸提25min,浸提结束后,2层的80-100 目纱布过滤得滤液I;所述滤渣与水按照质量体积比为1:2.5的固液比混合,按照同样的方 法进行超声波辅助浸提、过滤,重复2次,得滤液II;合并滤液I、滤液II即得水浸提液。
(3)超声逆流提取:向步骤(2)所得的浸提滤渣与58%乙醇按照质量体积比为1:2.5 的固液比混合,在1100W超声波辅助作用下逆流提取60min后,2层的90目纱布过滤得提取液I;滤渣加等重量的58%乙醇按照同样的方法进行超声波辅助逆流提取、过滤,重 复1次,得提取液II;合并提取液I、提取液II即得逆流提取液。
(4)水煎煮提取:取蝉蜕、蛇床子、白花蛇舌草以及连翘加6倍重量的水浸泡1.5h,然后武火煮开,转文火煎1.8h后,过滤,收集煎煮液I;药渣加3倍重量的水武火煮开, 转文火煎0.5h后,过滤,收集煎煮液II;合并煎煮液I、煎煮液II即得水煎煮液。
(5)混合、浓缩:待步骤(4)制备的水煎煮液冷却至50℃以下,加入步骤(2)制 备的水浸提液以及步骤(3)制备的逆流提取液混合均匀,然后在40℃条件下低温蒸发浓 缩得中药稠液。
(6)消毒灭菌:将步骤(5)制备的中药稠液采用紫外线消毒灭菌,加入茶树精油混合后,经无菌装袋或罐装后即得300g成品。
由该方法制备的犬用中药浴液组合物在使用时,按照药液:水(水温不易超过60℃, 以防药物中活性成分失活,降低药效)为1:500-1000的体积比(预防浓度偏低即可,治疗 浓度偏大)混合后,为宠物犬喷浴或者淋浴皆可,浸泡或者淋浴后,是否用清水清洗均可, 因为有精油气味的遮盖,即使不用清水清洗药味也不明显,并且预防和治疗效果更加持久。
实施例4
一种犬用中药浴液组合物及其制备方法,包括以下中草药原料中的各组分:苦参,蝉 蜕,杏仁,艾草,蛇床子,白花蛇舌草,连翘,薄荷,芦荟,蜂胶,黄花蒿,还包括大蒜 蒜瓣,青盐,柠檬草精油、香榧精油、茶树精油。中草药原料中各组分的具体配比如表1 所示。
一种犬用中药浴液组合物的制备方法,包括以下步骤:
(1)原料处理:将苦参、杏仁、薄荷、芦荟、蜂胶、黄花蒿、大蒜蒜瓣以及艾草分 别进行45℃烘干18h,粉碎后过筛,然后加入青盐后充分混匀,得混合物。
(2)水浸提:将步骤(1)所得的混合物与水按照质量体积比为1:4.5的固液比混合,然后加热至45℃,在850W超声波辅助作用下,浸提28min,浸提结束后,2层的90目纱 布过滤得滤液I;所述滤渣与水按照质量体积比为1:3的固液比混合,按照同样的方法进行 超声波辅助浸提、过滤,重复3次,得滤液II;合并滤液I、滤液II即得水浸提液。
(3)超声逆流提取:向步骤(2)所得的浸提滤渣与55%乙醇按照质量体积比为1:2的固液比混合,在1000W超声波辅助作用下逆流提取70min后,2层的80目纱布过滤得 提取液I;滤渣加等重量的60%乙醇按照同样的方法进行超声波辅助逆流提取、过滤,重 复2次,得提取液II;合并提取液I、提取液II即得逆流提取液。
(4)水煎煮提取:取蝉蜕、蛇床子、白花蛇舌草以及连翘,加7倍重量的水浸泡2h,然后武火煮开,转文火5-2h后,过滤,收集煎煮液I;药渣加4倍重量的水武火煮开,转 文火煎1h后,过滤,收集煎煮液II;合并煎煮液I、煎煮液II即得水煎煮液。
(5)混合、浓缩:待步骤(4)制备的水煎煮液冷却至50℃以下,加入步骤(2)制 备的水浸提液以及步骤(3)制备的逆流提取液混合均匀,然后在45℃条件下低温蒸发浓 缩得中药稠液。
(6)消毒灭菌:将步骤(5)制备的中药稠液采用紫外线消毒灭菌,加入柠檬草精油、香榧精油、茶树精油混合后,经无菌装袋或罐装后即得300g成品。
由该方法制备的犬用中药浴液组合物在使用时,按照药液:水(水温不易超过60℃, 以防药物中活性成分失活,降低药效)为1:100-500的体积比(预防浓度偏低即可,治疗浓度偏大)混合后,为宠物犬喷浴或者淋浴皆可,浸泡或者淋浴后,是否用清水清洗均可,因为有精油气味的遮盖,即使不用清水清洗药味也不明显,并且预防和治疗效果更加持久。
表1.各实施例中草药原料的组成配比
实施例5
1.犬用中药浴液组合物的体外真菌抑制试验
以本发明的实施例1-4制备的犬用中药浴液组合物(分别用双蒸水稀释成不同浓度梯 度)为实验组;以双蒸水作为空白对照组,以市售的克霉唑(购自上海宾智生物科技有限 公司,用双蒸水稀释成不同浓度梯度)作为阳性对照组。进行体外真菌抑制实验:将沙氏培养基在121℃、20min条件下高压灭菌,冷却后,取1ml各对照组、实验组稀释后的药 物进行涂布,接种后于28-30℃培养3天,进行观察,结果见表2。由表2可知,实施例4 的抗真菌效果最好,由此可见,一定配比的混合精油加入后,不光能够遮盖原中药中的气 味,还能够起一定的杀菌作用。
表2.各实施例犬用中药浴液组合物的抗真菌活性
表2中,MIC表示最小抑菌浓度,MSC表示最小杀菌浓度(稀释前原浓度为1)。
2.犬用中药浴液组合物的体外细菌抑制试验
以本发明的实施例1-4制备的犬用中药浴液组合物(分别用双蒸水稀释成不同浓度梯 度)为实验组;以双蒸水作为空白对照组,以市售的青霉素(购自生工生物工程(上海)股份有限公司,用双蒸水稀释成不同浓度梯度)作为阳性对照组。进行体外细菌抑制实验:将LB培养基在121℃、20min条件下高压灭菌,冷却后,取1ml各对照组、实验组稀释后 的药物进行涂布,接种后于37℃培养24天,进行观察,结果见表3。由表3可知,实施 例4的真菌抑制效果最好,由此可见,一定配比的混合精油加入后,不光能够遮盖原中药 中的气味,还能够起一定的杀菌作用。
表3.各实施例犬用中药浴液组合物的抗细菌活性
表3中,MIC表示最小抑菌浓度,MSC表示最小杀菌浓度(稀释前原浓度为1)。
3.犬用中药浴液组合物对螨虫的抑制试验
3.1实验分组:以本发明的实施例4制备的犬用中药浴液组合物(分别用双蒸水稀释 成100%、50%、25%、10%、1%、0.1%、0.01%浓度)为实验组;以双蒸水作为空白对 照组,以设2%甲硝唑溶液为阳性对照组作为阳性对照组。每组供试蠕形螨为10只,每个 药液浓度重复3次实验,结果取平均值。
3.2观察方法:用微量移液器吸取500μL药液滴加于载波片上,用推片将药液均匀铺 开,将检出蠕形螨的胶带贴于载玻片上,保证药液与虫体充分接触。然后将载玻片置于人 工气候箱(温度30℃、湿度75%),12h后显微镜下观察蠕形螨死亡情况。
3.3死亡判断标准:在400倍显微镜下连续观察1min,螨体螯肢或足爪不动者初步判 断为死亡,30min后继续观察仍不动者确诊为死亡。
校正死亡率/%=(空白对照组存活虫数—处理组存活螨数)/空白对照组存活螨数×100
3.4结果
表4.不同浓度的实施例4的犬用中药浴液组合物矫正死亡率
组别 | 校正死亡率(%)±SE |
100%浓度 | 100 |
50%浓度 | 100 |
25%浓度 | 96±6.3 |
10%浓度 | 80±9.1 |
1%浓度 | 57±5.7 |
0.1%浓度 | 39±2.3 |
0.01%浓度 | 11±1.8 |
空白对照组(双蒸水) | 0 |
阳性对照组(2%甲硝唑溶液) | 62.7±2.5 |
由表4可知,该犬用中药浴液组合物对螨虫具有显著的杀灭效果;其杀螨效果随浓度 增大而增大,当其浓度达到50%时,螨虫致死率已经为100%;当溶液浓度为25%时,螨虫致死率为96%左右;当溶液浓度为10%时,螨虫致死率为80%左右;当溶液浓度为1%时,螨虫致死率为57%左右;当溶液浓度为0.1%时,螨虫致死率为39%左右。实验证明: 该犬用中药浴液组合物对蠕形螨有杀灭用作用且效果极为显著。
4.小鼠皮肤刺激实验
动物分组及实验前处理:取健康白色家兔20只,体重25-30g,公母各半,实验前饲养1周,并观察饮食和行为,若正常按照星币、体重随机分为5组,每组4只。给药前24h 将每组小鼠背部脊柱两侧被毛减去,每侧脱毛区面积均为1cm2。给药方法:将实施例4的 犬用中药浴液组合物分别用清水稀释0倍(原液)、10倍、100倍、1000倍、10000倍, 分别涂于每组小鼠的左侧脱毛区,涂抹5次,每次用量1ml;小鼠的右侧脱毛区涂以等量 的清水;给药后,将两侧脱毛区均覆盖纱布(下)和保鲜膜(上),并用胶布固定,保持 药物与皮肤接触6h后去除纱布和保鲜膜,然后以温水洗去残留药物(右侧脱毛区同样用 温水清洗);每天给药1次,连续7d。每次去除药物2h及再次给药前观察皮肤状态。末次 给药及去除药物后1、12、24、48再次观察并记录涂抹部位有无红斑和水肿及恢复情况, 其评价标准见表5、表6。
表5.皮肤刺激反应症状标准
表6.皮肤刺激强度评价
分值 | 评价 |
0-0.5 | 无刺激性 |
0.5-2 | 轻度刺激性 |
2-6 | 中毒刺激性 |
6-8 | 强度刺激 |
通过实验给药和肉眼观察可知,右侧脱毛区的皮肤试验全程均无明显红斑、水肿等皮 肤刺激反应症状;左侧脱毛区中,实施例4的犬用中药浴液组合物原液以及稀释了10倍 (即10%浓度)的稀释液在去除药物1h以及末次给药后末次给药及去除药物后1h有轻度红斑和水肿,勉强可见,但是去除药物6h后以及末次给药后末次给药及去除药物后12h 后红斑和水肿消失不见;稀释了100倍(即1%浓度)及以上倍数的稀释液对左侧脱毛区 中进行涂抹,每天去除药物后1h、再次给药前以及末次给药后末次给药及去除药物后1、 12、24、48h均无明显红斑、水肿等皮肤刺激反应症状,各项分值均为零。由此可见,本 发明的犬用中药浴液组合物原液稀释100倍及以上倍数(即浓度低于1%),给宠物犬进行 淋浴或喷浴是安全的。
5.犬类治疗效果
在某宠物医院治疗由细菌、真菌和寄生虫引起犬传染性皮肤病,患病犬面部、颈部、 背部、腹部皮肤潮红、剧痒,感染处发生不同程度的脱毛。患处有脓疱,皮肤增厚,除掉痂皮后皮肤湿润并呈鲜红色。病犬耳尖和尾根等处被覆大量痂皮和鳞屑,头面部和体表其它部位断毛,圆形脱毛区皮屑较多。
对病犬使用本发明实施例1-4提供的药物稀释100倍(即原液的1%浓度)作为实验组;空白对照组不适用药物治疗,仅用清水浸泡。具体操作为:给犬类浸泡30min(水温 控制35-40℃),每隔2天浸泡一次,连用10天,效果显著,判定标准见表7,具体情况见 表8。
表7.犬类皮肤疾病治愈判定标准
表8.不同药物对不同犬类皮肤病的治疗效果
由表7和表8可知,应用本发明的实施例1-4的1%浓度的犬用中药浴液组合物,治愈率在80%以上,总有效率在90%以上,由此看出,本发明的犬用中药浴液组合物对于 治疗由细菌、真菌和寄生虫引起犬传染性皮肤病具有良好的效果。
虽然,上文中已经用一般性说明及具体实施例对本发明作了详尽的描述,但在本发明 基础上,可以对之作一些修改或改进,这对本领域技术人员而言是显而易见的。因此,在 不偏离本发明精神的基础上所做的这些修改或改进,均属于本发明要求保护的范围。
Claims (10)
1.一种犬用中药浴液组合物及其制备方法,其特征在于:包括以下重量份的中草药原料中的各组分:苦参10-15份,蝉蜕3-5份,杏仁6-10份,艾草20-30份,蛇床子10-15份,白花蛇舌草5-8份,连翘5-6份,薄荷10-15份,芦荟10-15份,蜂胶3-5份。
2.根据权利要求1所述的犬用中药浴液组合物,其特征在于:还包括黄花蒿6-8份。
3.根据权利要求2所述的犬用中药浴液组合物,其特征在于:还包括大蒜蒜瓣10-13份。
4.根据权利要求3所述的犬用中药浴液组合物,其特征在于:还包括青盐2-3份。
5.根据权利要求4所述的犬用中药浴液组合物,其特征在于:还包括精油0.5-2份;所述精油为柠檬草精油、香榧精油、茶树精油的一种或多种。
6.根据权利要求5所述的犬用中药浴液组合物,其特征在于:所述精油为柠檬草精油、香榧精油、茶树精油按照重量比1:2:1.5混合而成。
7.根据权利要求4-6任一项所述的犬用中药浴液组合物的制备方法,其特征在于,包括以下步骤:
(1)原料处理:将苦参、杏仁、薄荷、芦荟、蜂胶、黄花蒿、大蒜蒜瓣以及艾草分别进行烘干,粉碎后过筛,然后加入青盐后充分混匀,得混合物;
(2)水浸提:将步骤(1)所得的混合物加水后加热,超声波辅助作用下进行浸提,浸提结束后,过滤得滤液I;滤渣加水按照同样的方法进行超声波辅助浸提、过滤,重复2-3次,得滤液II;合并滤液I、滤液II即得水浸提液;
(3)超声逆流提取:向步骤(2)所得的浸提滤渣中加入55-60%乙醇,超声波辅助作用下逆流提取,过滤得提取液I;滤渣加等重量的55-60%乙醇按照同样的方法进行超声波辅助逆流提取、过滤,重复1-2次,得提取液II;合并提取液I、提取液II即得逆流提取液;
(4)水煎煮提取:取蝉蜕、蛇床子、白花蛇舌草以及连翘,加5-8倍重量的水浸泡1-2h,然后武火煮开,转文火煎1.5-2h后,过滤,收集煎煮液I;药渣加2-4倍重量的水武火煮开,转文火煎0.5-1h后,过滤,收集煎煮液II;合并煎煮液I、煎煮液II即得水煎煮液;
(5)混合、浓缩:待步骤(4)制备的水煎煮液冷却至50℃以下,加入步骤(2)制备的水浸提液以及步骤(3)制备的逆流提取液混合均匀,然后低温蒸发浓缩得中药稠液;
(6)消毒灭菌:将步骤(5)制备的中药稠液消毒灭菌,加入精油混合后,经无菌装袋或罐装后即得成品。
8.根据权利要求7所述的犬用中药浴液组合物的制备方法,其特征在于:步骤(1)中,烘干温度为35-50℃,烘干时间为12-24h;粉碎后过60目筛;步骤(2)中,所述混合物与水按照质量体积比为1:3-5的固液比混合,然后加热至40-50℃,在700-900W超声波辅助作用下,浸提20-30min,浸提结束后,1-3层的80-100目纱布过滤得滤液I;所述滤渣与水按照质量体积比为1:2-3的固液比混合。
9.根据权利要求7所述的犬用中药浴液组合物的制备方法,其特征在于:步骤(3)中,所述浸提滤渣与55-60%乙醇按照质量体积比为1:2-3的固液比混合,在1000-1200W超声波辅助作用下逆流提取50-80min后,1-3层的80-100目纱布过滤得提取液I。
10.根据权利要求7所述的犬用中药浴液组合物的制备方法,其特征在于:步骤(5)中,低温蒸发的温度为40-45℃;步骤(6)中,所述消毒灭菌方式为紫外线消毒灭菌或20KGy60Co消毒灭菌中的一种。
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