CN108057179B

CN108057179B - Multi-angle imaging device for radiation-free and non-invasive radiotherapy

Info

Publication number: CN108057179B
Application number: CN201711415122.7A
Authority: CN
Inventors: 李毅; 韩苏夏
Original assignee: First Affiliated Hospital of Medical College of Xian Jiaotong University
Current assignee: First Affiliated Hospital of Medical College of Xian Jiaotong University
Priority date: 2017-12-20
Filing date: 2017-12-20
Publication date: 2019-12-24
Anticipated expiration: 2037-12-20
Also published as: CN108057179A

Abstract

The invention discloses a multi-angle imaging device for radiation therapy without radiation and trauma, which comprises a detector connected with an X-ray emission device, wherein the detector comprises a CCD (charge coupled device) which is packaged in a shell and used for collecting Cerenkov photons, and a filter is also arranged on the CCD. The detector is packaged in front of a KV-level X-ray bulb tube of the X-ray transmitting device and is orthogonal to the MV-level machine head; the MV-grade handpiece of the X-ray emission device can rotate to irradiate for at least 180 degrees, and the CCD rotates along with the MV-grade handpiece to collect Cerenkov photons for imaging. According to the multi-angle imaging device for radiation-free and trauma-free radiotherapy, the detector is packaged in the machine head of the X-ray emission device and can randomly rotate in the multi-angle X-ray treatment process, so that the detector collects signals and is not influenced by the accelerator frame. This imaging method has the advantage of being fast, the three-dimensional image being moveable over time.

Description

Multi-angle imaging device for radiation-free and non-invasive radiotherapy

Technical Field

The invention belongs to the technical field of radiotherapy equipment, and relates to a multi-angle imaging device for radiation-free and non-invasive radiotherapy.

Background

At present, radiotherapy becomes one of the standard treatment means after breast tumor breast protection. In order to reduce the radiotherapy position error, the image-guided radiotherapy technology is developed rapidly.

In 2006, warian, usa and medical and kodad, sweden developed radioactive imaging systems, and KV-X ray bulbs and a large-sized amorphous silicon flat panel detector were respectively mounted on two mechanical arms, and KV and MV images could be acquired at the same time. The real-time respiration tracking system developed by America department of America and Cereus consists of 2 cameras and amorphous silicon detectors which are distributed indoors, and is fused with a digital reconstruction image DRR in a 2D or 3D mode, so that the position change of a patient is judged at a speed close to real time, and the movement of the patient is corrected in time in the treatment process. However, the above schemes all adopt an X-ray radiation mode, so that the patient receives unnecessary dose radiation, and the accuracy of tumor receiving dose cannot be verified.

In 2014, warian and swedish medical and Kodak companies developed radioactive imaging systems with imaging speed of minute order and patient respiratory cycle of millisecond order, which cannot realize real-time imaging of breast tumor.

In 2016, the C-Dose produced by DoseOptics corporation in America is the only Cerenkov Luminescence Imaging (CLI) device developed at present and applied to tumor radiotherapy, and the technology has the advantages of short imaging time, good sensitivity, high cost performance, no radiation and the like, and is applied to the Dose imaging research of breast tumor therapy. However, C-Dose pull-out time is short, which also exposes some significant problems during application. In the breast cancer treatment process, the detector is arranged at a fixed position around, the detection range is limited, particularly in the multi-angle treatment process, the treatment angle is large and the change is fast, and the detector is influenced by the accelerator frame and cannot collect signals; similar problems exist in multi-angle intensity modulated therapy, and the above factors limit the application of CLI in the complex tumor radiotherapy technology.

Disclosure of Invention

The invention aims to provide a multi-angle imaging device for radiation therapy without radiation and trauma, which can be used for imaging the absorbed dose of body surface tissues by collecting Cerenkov photons generated during radiation therapy and multi-angle collection imaging.

The invention is realized by the following technical scheme:

a multi-angle imaging device for radiation therapy without radiation and trauma comprises a detector connected with an X-ray emission device, wherein the detector comprises a CCD (charge coupled device) which is packaged in a shell and used for collecting Cerenkov photons, and a filter is also arranged on the CCD;

the detector is packaged in front of a KV-level X-ray bulb tube of the X-ray transmitting device and is orthogonal to the MV-level machine head;

the MV-grade handpiece of the X-ray emission device can rotate to irradiate for at least 180 degrees, and the CCD rotates along with the MV-grade handpiece to collect Cerenkov photons for imaging.

The detection angle of the detector is at right angles to the ray angle of MV level, which changes with the ray angle of MV level.

The CCD collects Cerenkov photons generated by a human body during radiotherapy through a 695-plus 770nm filter plate, and the absorbed dose of the body surface tissues is imaged.

Compared with the prior art, the invention has the following beneficial technical effects:

the multi-angle imaging device for radiation therapy without radiation and trauma provided by the invention can be used for imaging while treating tumors by X-rays; when the body surface absorbs X-rays, Cerenkov photons are emitted at a divergence angle of 60 degrees; the CCD of the detector can collect Cerenkov photon two-dimensional imaging. Because Cerenkov photons are proportional to the absorbed dose of body surface tissue, the Cerenkov photon two-dimensional image can be converted into a two-dimensional dose image.

According to the multi-angle imaging device for radiation-free and trauma-free radiotherapy, the detector is packaged in the machine head of the X-ray emission device and can randomly rotate in the multi-angle X-ray treatment process, so that the detector collects signals and is not influenced by the accelerator frame.

The invention provides a multi-angle imaging device for radiation-free and trauma-free radiotherapy, which adopts a hardware structure combining a CCD (charge coupled device) and a filter and adopts a mixed spectrum Cerenkov luminescence imaging method to reconstruct a plurality of groups of two-dimensional images into three-dimensional images. The imaging method has the advantage of rapidness, and the three-dimensional image can move along with time, so that four-dimensional dynamic body surface dosage imaging can be further formed.

The method collects Cerenkov photon imaging generated in the tumor radiotherapy process, does not utilize additional rays to irradiate a patient, does not generate interference on the treatment of the patient, and achieves radiation-free and noninvasive dose imaging.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic diagram of a detector of the present invention;

wherein, 1 is an emergent MV level X-ray machine head; 2, an emergent KV X-ray bulb tube; 3 is a detector; 4 is CCD; and 5 is a filter plate.

Detailed Description

The present invention will now be described in further detail with reference to specific examples, which are intended to be illustrative, but not limiting, of the invention.

As shown in fig. 1, a multi-angle imaging device for radiation therapy without radiation and trauma comprises a detector connected with an X-ray emission device, wherein the detector comprises a CCD (charge coupled device) which is packaged in a shell and used for collecting Cerenkov photons, and a filter is also arranged on the CCD;

Further, the detection angle of the detector is at right angles to the ray angle of MV level, which changes with the ray angle of MV level. Specifically, the CCD collects Cerenkov photons generated by a human body during radiotherapy through a 695-plus 770nm filter, and the Cerenkov photons are used for imaging absorbed dose of body surface tissues. The MV-grade handpiece is used for X-ray treatment, when X-rays irradiate the body surface of a human body, Cerenkov radiation is generated, and a detector collects Cerenkov photons to absorb X-ray dose on the body surface for imaging.

As shown in FIG. 2, the middle of the detector component is empty, and the X-ray tube is not influenced to emit X-rays. Meanwhile, the detector wall material is an alloy material, so that X rays are shielded, and the influence of KV-level and MV-level rays is eliminated.

Some specific parameters of the CCD are given below.

The following gives specific modes of use:

1. before tumor radiotherapy begins, a combination of detectors is selected, and an imaging mode is selected.

2. And (4) opening a detector switch in software and standing by.

3. At the beginning of tumor radiotherapy, the software can display the body surface irradiation dose imaging, the CCD imaging needs to be imported into the computer, and the imaging result is shown in fig. 3 by the software LightField (instruments of princeton university, trenden, new jersey, usa) carried by the CCD.

The embodiments given above are preferable examples for implementing the present invention, and the present invention is not limited to the above-described embodiments. Any non-essential addition and replacement made by the technical characteristics of the technical scheme of the invention by a person skilled in the art belong to the protection scope of the invention.

Claims

1. A multi-angle imaging device for radiation-free and trauma-free radiotherapy is characterized by comprising a detector connected with an X-ray transmitting device, wherein the X-ray transmitting device comprises a KV-level X-ray device and an MV-level X-ray device, the KV-level X-ray device comprises a KV-level X-ray bulb tube, the MV-level X-ray device comprises an MV-level X-ray machine head, the detector is connected with the KV-level X-ray device of the X-ray transmitting device, the detector component is of a hollow annular structure in the middle, the detector wall material is an alloy material, the detector comprises a CCD (charge coupled device) which is packaged in a shell and used for collecting Cherenkov photons, and a filter plate is further arranged on the CCD, wherein the CCD is packaged in the shell of the detector and is positioned in an annular area part of the;

the detector is packaged in front of a KV-level X-ray bulb tube of the X-ray transmitting device and is orthogonal to the MV-level machine head, and the plane where the ring of the detector is located is parallel to the exit direction of the MV-level X-ray;

the MV-grade X-ray machine head of the X-ray transmitting device can rotate around a treatment position to irradiate for at least 180 degrees, and the KV-grade X-ray device rotates around the treatment position along with the MV-grade X-ray machine head, so that a detector packaged in front of the KV-grade X-ray bulb tube carries the CCD to rotate around the treatment position along with the MV-grade X-ray machine head to collect Cerenkov photons for imaging.

2. The multi-angle imaging device for radiation therapy without radiation and trauma as claimed in claim 1, wherein the CCD collects Cerenkov photons generated by human body during radiation therapy through 695-and 770-nm filter to image absorbed dose on the body surface tissue.