CN108042866A - For treating the plasma filtering device of acute cerebral infarction and method - Google Patents
For treating the plasma filtering device of acute cerebral infarction and method Download PDFInfo
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- CN108042866A CN108042866A CN201711126985.2A CN201711126985A CN108042866A CN 108042866 A CN108042866 A CN 108042866A CN 201711126985 A CN201711126985 A CN 201711126985A CN 108042866 A CN108042866 A CN 108042866A
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- filter membrane
- plasma
- lower casing
- filtering device
- upper casing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
Abstract
The present invention provides a kind of new plasma filtering device and method that are used to treat acute cerebral infarction, described device includes shell and filtration core, shell includes upper casing and the lower casing engaged with upper casing, upper casing forms an accommodation space with lower casing, filtration core is arranged in accommodation space, the filtration core includes the first filter membrane, second filter membrane and the 3rd filter membrane, it is flowed to along blood plasma, according to the first filter membrane, second filter membrane, first filter membrane, the arrangement mode of first filter membrane and the 3rd filter membrane forms the filtration core, wherein, first filter membrane is with liposome, fibrinogen affinity adsorption function DELP films, second filter membrane is absorption inflammatory factor and the EKSP in-depth filtration films of free radical, 3rd filter membrane is 0.2 micron membranes for filtering out various particulate materials of the aperture more than 0.2 micron.The advantage is that the plasma filtering device can be used for the blood plasma of filtering acute cerebral infarction patients.
Description
Technical field
The present invention relates to medical instruments field more particularly to a kind of new plasmapheresis dresses for being used to treat acute cerebral infarction
It puts and method.
Background technology
Cerebrovascular disease has become first of China city and people in the countryside and has disabled and the cause of death at present, and morbidity have by
The trend that year increases.Epidemiological study shows the Chinese case for having 1,500,000~200 Wan Xinfa cerebral apoplexies every year, corrects the age
Year Cerebral Haemorrhage Invasion Rate afterwards is（116~219）/ 10 ten thousand populations, year Stroke Death rate be（58~142）/ 10 ten thousand populations.
In addition, existing more than 700 ten thousand people of patients with cerebrovascular disease in China wherein about 70% is cerebral arterial thrombosis, has quite
Ratio with Other Risk Factors, be the high-risk individuals of Recurrent Stroke.It is fast with aging of population and economic level
Speed development and the variation of life style, cerebral arterial thrombosis incidence substantially rise, prompt based on atherosclerosis
Ischemic cerebrovascular disease is [including transient ischemic attack（TIA）] incidence increasing.
Treatment of Cerebral Stroke includes：1. general treatment, including breathing, cycling, treatment, the controlling of blood pressure of body fluid volume and metabolism,
The prevention of cerebral arterial thrombosis simultaneously treats epilepsy, venous thromboembolism, dysphagia, aspiration pneumonia, other infection, bedsores,
And intracranial hypertension is handled if necessary.2. special treatment is controlled including thromboembolism treatment, interventional treatment, Antiplatelet therapy, anti-freezing
It treats, calcium ion antagonist is treated, cerebral metabolism activator is treated, prevents cerebral edema treatment, lipid-lowering therapy, surgical intervention, traditional Chinese medicine
Treatment etc..
At present, blood filtration has become a very universal therapeutic modality of application, is widely used in and substitutes liver, kidney and dimension
Hold the treatment of vital sign.Stroke clinical also has similar using lipid-loweringing filtering adsorption technology, reduction patient sign index：Such as
By cholesterol（TC）, triglycerides（TG）, low-density lipoprotein（LDL）Whole body removes more than 50% product.However, by facing
Bed observation, statistics find that in cerebral infarction acute attack stage, the different high Proportion of patients of blood lipids index is relatively low, but within the stage of attack
Can generate more inflammatory factor and free radical, and existing filter device not can prove that its have filtering removal inflammatory factor and
Free Radical；Another acute cerebral infarction patients vital sign is unstable, and to ensure safety, clinical practice should be used and followed outside smaller body
The blood filtration technology and method of circular rector reduces volume, it is necessary to which crushing resistance is more preferable, the filter medium of pollutant holding capability bigger.
Therefore new it is directed to the dedicated filtering adsorpting device of acute cerebral infarction patients there is an urgent need for a kind of.
The content of the invention
The technical problem to be solved by the invention is to provide it is a kind of for treat acute cerebral infarction plasma filtering device and
The harmful substance that its capacity of method is small, security is good, effective filtering acute cerebral infarction generates, crushing resistance is strong, pollutant holding capability is big.
To solve the above-mentioned problems, the present invention provides a kind of for treating the plasma filtering device of acute cerebral infarction, bag
Shell and filtration core are included, the shell includes upper casing and the lower casing engaged with the upper casing, the upper casing are formed with the lower casing
One accommodation space, the filtration core are arranged in the accommodation space, and the filtration core includes the first filter membrane, the second filter membrane
And the 3rd filter membrane, it is flowed to along blood plasma, according to the first filter membrane, the second filter membrane, the first filter membrane, the first filter membrane and
The arrangement mode of three filter membranes forms the filtration core, wherein, first filter membrane is with liposome, fibrinogen parent
Closing adsorption function DELP films, second filter membrane is absorption inflammatory factor and the EKS P in-depth filtration films of free radical, described the
Three filter membranes are 0.2 micron membranes for filtering out various particulate materials of the aperture more than 0.2 micron.
Further, in the filtration core, the number of plies summation of first filter membrane, the second filter membrane and the 3rd filter membrane
For 5 ~ 10 layers, wherein, the number of plies summation of first filter membrane is 3 ~ 7 layers, and the number of plies summation of second filter membrane is 1 ~ 2
Layer, the number of plies of the 3rd filter membrane is 1 layer.
Further, the 3rd filter membrane is 020 polyether sulfone sterilised membrane filter.
Further, the upper casing is integrally formed with the lower casing.
Further, a valve jacket is further included, the valve jacket is around the side for coating the upper casing and the lower casing, by described in
Upper casing is fixedly connected with the lower casing.
Further, for the upper casing in the concave structure that Open Side Down, the lower casing is in the concave structure of opening upwards, described
Upper casing is Chong Die with the lower casing lateral section, and the valve jacket has the upper casing limiting section being oppositely arranged and lower casing limiting section, described
Upper casing limiting section compresses the Upper portion outer surface, and the lower casing limiting section compresses the bottom housing section outer surface.
Further, the lower casing inner surface is provided with a plurality of divergent shape drainage trough, and the blood plasma after filtering introduces blood plasma
Outlet.
Further, the divergent shape drainage trough is circular configuration, is provided with along the divergent shape drainage trough radial direction
The liquid that divergent shape drainage trough accommodates is led to plasma outlet port by multiple drainage channels, the drainage channel.
Further, the bulb that at least one width broadens is provided on each drainage channel.
Further, the maximum gauge of the accommodation space is less than 150 millimeters.
The present invention provides a kind of plasmapheresis method, includes the following steps：Blood plasma injects filter device from plasma inlet；Blood
Slurry passes through the first filter membrane set gradually, the second filter membrane, the first filter membrane, the first filter membrane and the 3rd filtering membrane filtration,
Wherein, first filter membrane is with liposome, fibrinogen affinity adsorption function DELP films, and second filter membrane is
Adsorb the EKS P in-depth filtration films of inflammatory factor and free radical, the 3rd filter membrane is that filter out aperture each more than 0.2 micron
Kind particulate material；Blood plasma after filtering is discharged from plasma outlet port.
Further, the number of plies summation of the blood plasma passes through first filter membrane, the second filter membrane and the 3rd filter membrane
For 5 ~ 10 layers, wherein, the number of plies summation of first filter membrane is 3 ~ 7 layers, and the number of plies summation of second filter membrane is 1 ~ 2
Layer, the number of plies of the 3rd filter membrane is 1 layer.
Further, the blood plasma after filtering leads to plasma outlet port by being arranged on the drainage trough of lower casing inner surface.
It is an advantage of the current invention that reduce liposome, fibrinogen, part inflammatory factor and the freedom in blood plasma
Base, less than 0.2 micron particles content of material, improve hemorheology, reduce cardiopulmonary bypass in patients amount（<200ml, by JX-
II -110 models of DELP- calculate）, increase clinical safety, treatment and the clinical symptoms for reducing acute cerebral infarction patient, and capacity
Harmful substance small, security is good, effective filtering acute cerebral infarction generates, crushing resistance is strong, pollutant holding capability is big.
Description of the drawings
Fig. 1 is the structure diagram that the present invention is used to treat the plasma filtering device of acute cerebral infarction；
Fig. 2 is the schematic top plan view of the divergent shape drainage trough of plasma filtering device.
Specific embodiment
Below in conjunction with the accompanying drawings to the plasma filtering device and filter method provided by the present invention for treating acute cerebral infarction
Specific embodiment elaborate.
Referring to Fig. 1, the present invention includes shell 1 and filtration core 2 for treating the plasma filtering device of acute cerebral infarction.
The shell 1 includes upper casing 11 and the lower casing 12 engaged with the upper casing 11, the upper casing 11 and the lower casing 12
Form an accommodation space.Preferably, the upper casing 11 is integrally formed with the lower casing 12, for example, can pass through the method one of injection
It is body formed.The advantage is that, with it is existing glue bonding by way of compared with, it is safer, hygienic, reduce production process in work
Make personnel's maloperation, filter apparatus configuration is more stable, firm, beneficial to transport.Preferably, the maximum gauge of the accommodation space is small
In 110 millimeters, such as 100 millimeters.
Preferably, the plasma filtering device further includes a valve jacket 3.The valve jacket 3 is around the cladding upper casing 11 and institute
The side of lower casing 12 is stated, the upper casing 11 is fixedly connected with the lower casing 12, can further reinforce upper casing 11 under
The connection of shell 12 makes filter apparatus configuration more stable, firm, beneficial to transport.
In this embodiment, the upper casing 11 is in the concave structure that Open Side Down, the lower casing 12 in opening to
On concave structure, the upper casing 11 is Chong Die with 12 lateral section of lower casing, strengthens sealing the shell with further, prevent
During use, blood plasma leaks.The valve jacket 3 has the upper casing limiting section 31 that is oppositely arranged and a lower casing limiting section 32, it is described on
Shell limiting section 31 compresses 11 partial outer face of upper casing, and the lower casing limiting section 32 compresses 12 partial outer face of lower casing,
And then the valve jacket 3 is made to lock the upper casing 11 and the lower casing 12, the connection of upper casing 11 and lower casing 12 is further reinforced, and is prevented
Stopping leak reveals.Preferably, the side of the lower casing 12 props up the lower surface of the upper casing limiting section 31 upwards, to provide enough appearances
Receive space filtration core.Further, the height of the side of the lower casing 12 and accommodation space is highly consistent.
Further, the upper casing 11 further includes plasma inlet 111 and exhaust outlet 112, and the lower casing 12 further includes blood plasma and goes out
Mouth 121.During blood plasma is from plasma inlet 111 into the plasma filtering device, discharged after flowing through filtration core 2 through plasma outlet port 121.
The exhaust outlet 112 is used to discharge the gas in plasma filtering device.
Further, 12 inner surface of lower casing is provided with a plurality of divergent shape drainage trough 122, will be after filter core 2 filters
Blood plasma introduce plasma outlet port 121.Fig. 2 is the schematic top plan view of the divergent shape drainage trough 122, the divergent shape drainage trough
122 be circular configuration, 122 radial direction of divergent shape drainage trough is provided with multiple drainage channels 123, the drainage is logical
The liquid that divergent shape drainage trough 122 accommodates is led to plasma outlet port 121 by road 123.Wherein, set on each drainage channel 123
Have a bulb 124 that at least one width broadens, the bulb 124 for caching liquid, can be as the buffering of liquid at, it is anti-
The only hypertonia in plasma filtering device, and further function as the effect for assisting drainage.Further, the drainage channel 123
Width W for 1mm ~ 5mm, for example, 2mm, 3mm, 4mm, the depth of the drainage channel 123 is 1mm ~ 5mm, for example, 2mm,
3mm、4mm。
The filtration core 2 is arranged in the accommodation space.The filtration core 2 is filtered including the first filter membrane 21, second
22 and the 3rd filter membrane 23 of film.It is flowed to along blood plasma, according to the first filter membrane 21, the second filter membrane 22, the first filter membrane 21,
The arrangement mode of one filter membrane 21 and the 3rd filter membrane 23 forms the filtration core 2.
Wherein, first filter membrane 21 is with liposome, fibrinogen affinity adsorption function DELP films（Following letter
Claim A）, for example, Minnesota Mining and Manufacturing Company's production has liposome, fibrinogen affinity adsorption function DELP films.Second mistake
Filter membrane 22 is the inflammatory factor of absorption cerebral infarction acute attack stage generation and the EKS P in-depth filtration films of free radical（Hereinafter referred to as
B）, for example, part inflammatory factor and the EKS of free radical that the absorption cerebral infarction acute attack stage of PALL companies of U.S. production generates
P in-depth filtration films.3rd filter membrane 23 is micro- to filter out the 0.2 of various graininess harmful substances of the aperture more than 0.2 micron
Rice film（Hereinafter referred to as C）, for example, U.S.'s PALL company systems, compare other materials, resistance to pressure and pollutant holding capability more preferably 020 polyethers
Sulfone sterilised membrane filter.Filtration core of the present invention is overlapped by A, B, A, A, C order, forms adsorption filtration fibrinogen, a fat successively
Plastid, part inflammatory factor, the device of free radical.In the present embodiment, first filter membrane 21, the second filter membrane 22 and
Three filter membranes 23 are a layer structure, arrangement form longitudinal direction five-layer structure, can further reduce the diameter of filtration core, for example,
The maximum gauge of the accommodation space is less than 150 millimeters, such as 140 millimeters of, 130 millimeters, 120 millimeters, 110 millimeters, 100 millis
Rice or 90 millimeters, and existing filter device has a diameter larger than 200 millimeters, therefore, the application filter device diameter is small, can
Extracorporal circulatory system blood volume when reducing patient's treatment promotes the security for the treatment of.
Preferably, in the filtration core, the number of plies summation of first filter membrane, the second filter membrane and the 3rd filter membrane
For 5 ~ 10 layers, wherein, the number of plies summation of first filter membrane is 3 ~ 7 layers, and the number of plies summation of second filter membrane is 1 ~ 2
Layer, the number of plies of the 3rd filter membrane is 1 layer.In the present embodiment, first filter membrane, the second filter membrane and the 3rd filtering
Film is a layer structure, arrangement form longitudinal direction five-layer structure.In an alternative embodiment of the invention, filtration core still by A, B, A,
A, C orders overlap, wherein, first filter membrane is double-layer structure, and that further enhances to liposome, fibrinogen
Absorption.In yet another embodiment of the invention, filtration core is still overlapped by A, B, A, A, C order, wherein, second filter membrane is
Double-layer structure, first filter membrane is also double-layer structure, on the basis for strengthening the absorption to liposome, fibrinogen
On, further enhance the absorption of the inflammatory factor and free radical that are generated to cerebral infarction acute attack stage.The present invention is to each mistake
The number of plies of filter membrane is not limited, as long as the object of the invention can be realized.
Acute cerebral infarction patients have high molecular weight protein polymerization effect, when in blood circulation flow process, office mostly
Portion's condition changes, condensate, particle agglomeration, causes blood vessel obstruction, and further triggers inflammatory factor and free radical accumulation,
Cause patient's poor prognosis.The present invention selects mechanical membrane filtration and/or compatible filtering method, reduces the lipid in blood plasma
Body, fibrinogen, part inflammatory factor and free radical, less than 0.2 micron particles content of material, improve hemorheology, reach
To the purpose for treating and reducing acute cerebral infarction patient's clinical symptoms.
Mechanical filter refer to the smaller various membrane materials in aperture by liposome, fibrinogen, inflammatory factor, free radical and
It is separated less than 0.2 micron particles substance etc. from blood plasma, the chemical composition of film must have biologically inert, not have to human body
Toxic side effect, such as cellulose, diatomite, have many commercial products available.Compatible filtering refers to various to blood plasma
Middle liposome, fibrinogen, inflammatory factor, free radical and the membrane filtration for having compatibility less than 0.2 micron particles substance, including
But it is not limited to：Film and Positively charged membrane containing silica etc. carry each based fine particles in blood plasma strong affinity interaction, meet people
All kinds of research and development commercialization membrane material products of body biocompatibility requirement.
The present invention is included the following steps using above-mentioned plasma filtering device filtered plasma method：
（1）Blood plasma injects filter device from plasma inlet；
（2）Blood plasma passes through the first filter membrane, the second filter membrane, the first filter membrane, the first filter membrane and the 3rd mistake set gradually
Membrane filtration, wherein, first filter membrane is with liposome, fibrinogen affinity adsorption function DELP films described the
The inflammatory factor and the EKS P in-depth filtration films of free radical that two filter membranes are generated for absorption cerebral infarction acute attack stage, described the
Three filter membranes is filter out aperture more than 0.2 micron, resistance to pressure and pollutant holding capability more preferably 020 polyether sulfone sterilised membrane filter；
（3）Blood plasma after filtering is discharged from plasma outlet port, and then realizes the purpose of filtering blood.Preferably, the blood plasma after filtering
Plasma outlet port is led to by the drainage trough for being arranged on lower casing inner surface.
Preferably, the number of plies summation of first filter membrane, the second filter membrane and the 3rd filter membrane is 5 ~ 10 layers, wherein,
The number of plies summation of first filter membrane is 3 ~ 7 layers, and the number of plies summation of second filter membrane is 1 ~ 2 layer, the 3rd filtering
The number of plies of film is 1 layer.Blood plasma through setting gradually the first filter membrane, the second filter membrane, the first filter membrane, the first filter membrane and
3rd filtering membrane filtration, in the present embodiment, filtration core is still overlapped by A, B, A, A, C order, wherein, first filter membrane
21 be double-layer structure, and that further enhances the absorption to liposome, fibrinogen.In yet another embodiment of the invention, mistake
Filter core still by A, B, A, A, C order overlap, wherein, second filter membrane 22 be double-layer structure, first filter membrane 21
Also it is double-layer structure, on the basis of the absorption to liposome, fibrinogen is strengthened, further enhances to cerebral infarction
The absorption of inflammatory factor and free radical that acute attack stage generates.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (14)
1. a kind of plasma filtering device for being used to treat acute cerebral infarction, which is characterized in that described outer including shell and filtration core
Shell includes upper casing and the lower casing engaged with the upper casing, and the upper casing forms an accommodation space, the filtration core with the lower casing
It is arranged in the accommodation space, the filtration core includes the first filter membrane, the second filter membrane and the 3rd filter membrane, along blood plasma
Flow direction, according to the arrangement mode structure of the first filter membrane, the second filter membrane, the first filter membrane, the first filter membrane and the 3rd filter membrane
Into the filtration core, wherein, first filter membrane is with liposome, fibrinogen affinity adsorption function DELP films, institute
The second filter membrane is stated as absorption inflammatory factor and the EKS P in-depth filtration films of free radical, the 3rd filter membrane is to filter out aperture
0.2 micron membranes of the various particulate materials more than 0.2 micron.
2. plasma filtering device according to claim 1, which is characterized in that the 3rd filter membrane for 020 polyether sulfone without
Bacterium filter membrane.
3. plasma filtering device according to claim 1, which is characterized in that in the filtration core, first filtering
The number of plies summation of film, the second filter membrane and the 3rd filter membrane is 5 ~ 10 layers, wherein, the number of plies summation of first filter membrane for 3 ~
7 layers, the number of plies summation of second filter membrane is 1 ~ 2 layer, and the number of plies of the 3rd filter membrane is 1 layer.
4. plasma filtering device according to claim 1, which is characterized in that the upper casing is integrally formed with the lower casing.
5. plasma filtering device according to claim 1, which is characterized in that further include a valve jacket, the valve jacket is around bag
The side of the upper casing and the lower casing is covered, the upper casing is fixedly connected with the lower casing.
6. plasma filtering device according to claim 1, which is characterized in that the upper casing is in the concave knot that Open Side Down
Structure, the lower casing are in the concave structure of opening upwards, and the upper casing is Chong Die with the lower casing lateral section, and the valve jacket has phase
To the upper casing limiting section of setting and lower casing limiting section, the upper casing limiting section compresses the Upper portion outer surface, the lower casing
Limiting section compresses the bottom housing section outer surface.
7. plasma filtering device according to claim 6, which is characterized in that the side of the lower casing is propped up on described upwards
The lower surface of shell limiting section.
8. plasma filtering device according to claim 1, which is characterized in that the lower casing inner surface is provided with a plurality of diverging
Shape drainage trough, the blood plasma after filtering introduce plasma outlet port.
9. plasma filtering device according to claim 8, which is characterized in that the divergent shape drainage trough is circular configuration,
The divergent shape drainage trough radial direction is provided with multiple drainage channels, the drainage channel accommodates divergent shape drainage trough
Liquid lead to plasma outlet port.
10. plasma filtering device according to claim 9, which is characterized in that be provided at least on each drainage channel
The bulb that one width broadens.
11. plasma filtering device according to claim 1, which is characterized in that the maximum gauge of the accommodation space is less than
150 millimeters.
A kind of 12. plasmapheresis method, which is characterized in that include the following steps：Blood plasma injects filter device from plasma inlet；
Blood plasma passes through the first filter membrane, the second filter membrane, the first filter membrane, the first filter membrane and the 3rd filter membrane mistake set gradually
Filter, wherein, first filter membrane is with liposome, fibrinogen affinity adsorption function DELP films, second filtering
Film is absorption inflammatory factor and the EKS P in-depth filtration films of free radical, and the 3rd filter membrane is more than 0.2 micron to filter out aperture
Various particulate materials 0.2 micron membranes；Blood plasma after filtering is discharged from plasma outlet port.
13. plasmapheresis method according to claim 12, which is characterized in that the blood plasma after filtering is by being arranged on lower casing
The drainage trough of inner surface leads to plasma outlet port.
14. plasmapheresis method according to claim 12, which is characterized in that first filtering that the blood plasma passes through
The number of plies summation of film, the second filter membrane and the 3rd filter membrane is 5 ~ 10 layers, wherein, the number of plies summation of first filter membrane for 3 ~
7 layers, the number of plies summation of second filter membrane is 1 ~ 2 layer, and the number of plies of the 3rd filter membrane is 1 layer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016112058549 | 2016-12-23 | ||
| CN201611205854.9A CN106540344A (en) | 2016-12-23 | 2016-12-23 | For treating the plasma filtering device and method of acute cerebral infarction |
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| CN108042866A true CN108042866A (en) | 2018-05-18 |
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| CN201611205854.9A Pending CN106540344A (en) | 2016-12-23 | 2016-12-23 | For treating the plasma filtering device and method of acute cerebral infarction |
| CN201711126985.2A Pending CN108042866A (en) | 2016-12-23 | 2017-11-15 | For treating the plasma filtering device of acute cerebral infarction and method |
| CN201721540035.XU Active CN208943042U (en) | 2016-12-23 | 2017-11-17 | For treating the plasma filtering device of hyperlipidemia |
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| CN201611205854.9A Pending CN106540344A (en) | 2016-12-23 | 2016-12-23 | For treating the plasma filtering device and method of acute cerebral infarction |
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| CN201721540035.XU Active CN208943042U (en) | 2016-12-23 | 2017-11-17 | For treating the plasma filtering device of hyperlipidemia |
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| CN110711493A (en) * | 2019-10-28 | 2020-01-21 | 上海泰滋生物科技有限公司 | Adsorption membrane, composite membrane module and filter |
| CN112076535B (en) * | 2020-09-09 | 2022-01-07 | 江苏恰瑞生物科技有限公司 | Biological enzyme-linked filter medium and preparation method thereof |
| CN112076359B (en) * | 2020-09-14 | 2022-10-28 | 江苏恰瑞生物科技有限公司 | Plasma adsorption filtering device for treating kidney stone and filtering method thereof |
| CN116421808B (en) * | 2023-03-09 | 2023-09-22 | 江苏恰瑞生物科技有限公司 | Plasma adsorption and filtration device for asthma treatment and filtration method thereof |
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| Title |
|---|
| 韩雄: "《脑卒中诊断与治疗学》", 31 August 2002 * |
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| Publication number | Publication date |
|---|---|
| CN208943042U (en) | 2019-06-07 |
| CN106540344A (en) | 2017-03-29 |
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