CN108042643A - A kind of preparation method of Traditional Chinese medicine for reducing blood glucose compound - Google Patents
A kind of preparation method of Traditional Chinese medicine for reducing blood glucose compound Download PDFInfo
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- CN108042643A CN108042643A CN201711331115.9A CN201711331115A CN108042643A CN 108042643 A CN108042643 A CN 108042643A CN 201711331115 A CN201711331115 A CN 201711331115A CN 108042643 A CN108042643 A CN 108042643A
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- cassia tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention relates to natural medicine field more particularly to a kind of preparation method of Traditional Chinese medicine for reducing blood glucose compound, preparation method are as follows：Weigh Chinese cassia tree and prepared rhizome of rehmannia；Chinese cassia tree is cleaned, is crushed after drying, adds ethyl alcohol, impregnate 23 it is small when, reflux decocts, and extracts 13 times, every time 12 it is small when, filtering, vacuum distillation removes ethyl alcohol, and is concentrated into the concentrate that 55 60 DEG C of relative densities are 1.20 1.25, spare；Prepared rhizome of rehmannia is cleaned, is crushed after drying, add in 68 times of weight purified water, reflux decoct 13 times, every time 13 it is small when, filtering, concentrate the filtrate to 55 60 DEG C of relative densities be 1.20 1.25 concentrate, it is spare；The concentrate of step 2 and step 3 is merged up to Traditional Chinese medicine compound composition of the present invention, the preparation method in the present invention is simple to operation, and product obtained is stablized, and plays an important role of to increase insulin sensitivity, promotion insulin secretion, reduction blood glucose.
Description
Technical field
The present invention relates to natural medicine field more particularly to a kind of preparation methods of Traditional Chinese medicine for reducing blood glucose compound.
Background technology
Diabetes are a kind of common, multiple endocrine and metabolic disorders diseases, and the specific cause of disease and pathogenesis are unknown, generally
Be considered due to internal insulin deficit or its cannot normally play physiological action and cause carbohydrate metabolism disturbance, then cause albumen
A kind of syndrome of many kinds of substance metabolic disorder such as matter, fat, water, electrolyte belongs to Traditional Chinese Medicine " diabete " scope.Sugar
Urine disease, clinic using hyperglycaemia as outstanding feature, be broadly divided into 1 type (insulin-dependent, IDDM) and 2 types (non-insulin according to
Rely type, NIDDM) two kinds, the former is the few insulin of islet β cell because insulin definitely lacks, so that it cannot suppression
Lipolysis processed has a large amount of ketoboidies to generate and cause ketoacidosis (DKA), and type 1 diabetes patient relies primarily on insulin
Treatment.The beta Cell of islet of diabetes B patient still has a certain amount of insulin secretion function, it is sufficient to it is excessive to inhibit adipose tissue
Free fatty discharges, and prevents the generation of spontaneous ketoacidosis, but hyperglycaemia long-term exists.Diabetes B patient's
Illness is mainly shown as metabolic disorder, and the most typical is exactly insulin resistance and insulin deficit, these exceptions cause blood glucose
Rise, and then improve the possibility that cardiovascular aspect disease occurs.For 2 patients with type Ⅰ DM, at present common oral hypoglycemic agents with
Based on Drugs Promoting Insulin Secretion and insulin sensitizer.For the treatment of diabetes B, there is a kind of alpha-glucosidase to inhibit
Agent, this kind of drug can improve muscle, fat to the uptake and utilization of glucose, the output for inhibiting liver glucose, reduction blood glucose.
But diabetes B is a kind of chronic disease, need to be taken medicine throughout one's life, while blood glucose is controlled, Western medicine adverse reaction occurs therewith.
Long-term taking medicine can bring all multiple organ injuries to patient, some reactions are more serious or even cause death.Wherein adverse reaction includes
Hypoglycemia, cardiovascular side effects, alimentary canal side reaction, lactic acidosis and liver renal toxicity etc..Therefore diabetic is anxious
Need with cutting it is easy to use, effect efficiently, stablize, persistently, Side effect is smaller and can delay complication occurrence and development
Hypoglycemic drug.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of preparation method of Traditional Chinese medicine for reducing blood glucose compound, for controlling
It treats and prevents diabetes, diabetic complication.
A kind of preparation method of Traditional Chinese medicine for reducing blood glucose compound, the Traditional Chinese medicine compound composition include following weight number
Active constituents of medicine：Chinese cassia tree general flavone 5-10mg/g, Chinese cassia tree polyphenol 6-11mg/g, procyanidine 0.5-1.0 mg/g, prepared rhizome of rehmannia
Polysaccharide 10-16mg/g, martynoside A 0.6-1.5mg/g, martynoside D 0.6-1.6mg/g, acteoside 0.5-1.5mg/g and
Catalpol 0.4-7.2mg/g, preparation method are as follows：
Step 1：Chinese cassia tree and prepared rhizome of rehmannia are weighed, the wherein weight ratio of Chinese cassia tree and prepared rhizome of rehmannia is 1:（1~2）；
Step 2：Chinese cassia tree is cleaned, is crushed after drying, adds 5-8 times of weight concentration for 60-70% ethyl alcohol, when immersion 2-3 is small, reflux
It decocts, extracts 1-3 time, when each 1-2 is small, filtering, vacuum distillation removing ethyl alcohol, and be concentrated into 55-60 DEG C of relative density and be
1.20-1.25 concentrate, it is spare；
Step 3：Prepared rhizome of rehmannia is cleaned, is crushed after drying, adds in the purified water of 6-8 times of weight, reflux decocts 1-3 times, each 1-
3 it is small when, filtering, concentrate the filtrate to 55-60 DEG C of relative density be 1.20-1.25 concentrate, it is spare；
Step 4：The concentrate of step 2 and step 3 is merged up to Traditional Chinese medicine compound composition of the present invention.
Chinese cassia tree general flavone：Chinese cassia tree also known as beautiful osmanthus and cassia bark are the fragrance medicines of a kind of medicine of preciousness, food and daily chemical product
Material, the comparison of ingredients of Chinese cassia tree is complicated, containing substances such as volatile ingredient, polysaccharide, terpene, phenols, flavone compounds, wherein
Antioxidant content species merits attention, and Cortex Cinnamomi volatile oil inoxidizability obtains certain progress, and the experimental results show flavones
Class compound has the works such as treatment cardiovascular and cerebrovascular disease, antibacterial, anti-inflammatory, analgesia, antiviral, antitumor, reduction blood glucose, reducing blood lipid
With；
Chinese cassia tree polyphenol：Phenols is a kind of important component in Chinese cassia tree, can increase insulin sensitivity, so as to reduce Metabolic syndrome
Disease, the danger of diabetes；
Procyanidine：The general name for the major class polyphenolic substance being widely present in plant, have it is extremely strong it is anti-oxidant, eliminate from
By the effect of base, ultra-oxygen anion free radical and hydroxyl radical free radical can be effectively eliminated, also assists in phosphoric acid, arachidonic metabolism
And protein phosphorylation, protect lipid that peroxide injury does not occur, be strong metal-chelator, can chelated metal ions,
Inert compound is formed in vivo；Protection and stable vitamin C, contribute to ascorbic absorption and utilization, procyanidine may be used also
With water-soluble and fat-soluble free radical in scavenger-cell film, therefore, it is suppressed that discharge some enzymes and remove injury capillary wall
Process；
Prepared rehmannia root polysaccharide：Prepared rehmannia root polysaccharide is one of distinctive active ingredient in " integration of drinking and medicinal herbs " prepared rhizome of rehmannia, and pharmacological research shows
Prepared rehmannia root polysaccharide has the physiological functions such as enhancing is immune, antitumor, enriches blood.
Martynoside A：Glutinous rehmannia is the dry tuber of scrophulariaceae rehmannia glutinosa plant, has the effect of clearing heat and cooling blood, yin-nourishing, promote the production of body fluid, ground
Xanthosine A plays an important role of enriching yin and adjusts to be immunized, and can enhance humoral immunity and cellular immune function；
Martynoside D：Glutinous rehmannia, which has, adjusts immune function, and antitumor, anti-aging, hypoglycemic effect to cardiovascular system, are made
Blood system, internal system, central nervous system etc. show certain pharmacological activity, and martynoside D is main in glutinous rehmannia
One of active ingredient；
Acteoside：Acteoside can reduce the fasting blood-glucose of diabetic mice after 20 days in gavage；After gavage 45 days
Can reduce fasting blood-glucose, postprandial blood sugar and the blood fat of mouse, improve serum insulin level, and can improve muscle glycogen content,
The effect prompting acteosides for enhancing insulin for reducing blood sugar are the main actives that sugared effect is started to control in Cistanche tubulosa,
One of its mechanism of action is to reduce carbohydrate digesting and assimilating in enteron aisle by inhibiting intestinal alpha-glucosidase enzyme；
Catalpol：Catalpol has the effects that anticancer, neuroprotection, anti-inflammatory, diuresis, hypoglycemic and hepatitis virus resisting, it is a kind of cyclenes
Ether terpene glucoside compounds, are primarily present in the plants such as glutinous rehmannia.
Compared with prior art, the present invention has following technical advantage：
Preparation method in the present invention is simple to operation, and product obtained is stablized, and having increases insulin sensitivity, promotes pancreas islet
Element secretion reduces the effect of blood glucose, while plays an important role of to adjust blood fat, improves liver function；The composition obtained of the present invention
It is also widely used in treating and preventing diabetes, diabetic complication and adjusting blood fat drug or health products.
Specific embodiment
It will be understood by those skilled in the art that technology disclosed in following embodiment represent the inventors discovered that in this hair
The technology of good action is played in bright practice.However, many changes can be made in disclosed specific embodiment, and
Still obtain the same or similar as a result, without departing from the spirit and scope of the present invention.
A kind of preparation method of Traditional Chinese medicine for reducing blood glucose compound, the Traditional Chinese medicine compound composition include following weight number
Active constituents of medicine：Chinese cassia tree general flavone 5-10mg/g, Chinese cassia tree polyphenol 6-11mg/g, procyanidine 0.5-1.0 mg/g, prepared rhizome of rehmannia
Polysaccharide 10-16mg/g, martynoside A 0.6-1.5mg/g, martynoside D 0.6-1.6mg/g, acteoside 0.5-1.5mg/g and
Catalpol 0.4-7.2mg/g, preparation method are as follows：
Step 1：Chinese cassia tree and prepared rhizome of rehmannia are weighed, the wherein weight ratio of Chinese cassia tree and prepared rhizome of rehmannia is 1:（1~2）；
Step 2：Chinese cassia tree is cleaned, is crushed after drying, adds 5-8 times of weight concentration for 60-70% ethyl alcohol, when immersion 2-3 is small, reflux
It decocts, extracts 1-3 time, when each 1-2 is small, filtering, vacuum distillation removing ethyl alcohol, and be concentrated into 55-60 DEG C of relative density and be
1.20-1.25 concentrate, it is spare；
Step 3：Prepared rhizome of rehmannia is cleaned, is crushed after drying, adds in the purified water of 6-8 times of weight, reflux decocts 1-3 times, each 1-
3 it is small when, filtering, concentrate the filtrate to 55-60 DEG C of relative density be 1.20-1.25 concentrate, it is spare；
Step 4：The concentrate of step 2 and step 3 is merged up to Traditional Chinese medicine compound composition of the present invention.
It is any in the spirit and/or scope of the present invention due to describing the present invention by more than preferred embodiment
Implement the present invention for replacement/of the invention or combination, will be apparent from for those skilled in the art, and
Among the present invention.
Claims (1)
1. a kind of preparation method of Traditional Chinese medicine for reducing blood glucose compound, which is characterized in that the Traditional Chinese medicine compound composition include with
The active constituents of medicine of lower weight number：Chinese cassia tree general flavone 5-10mg/g, Chinese cassia tree polyphenol 6-11mg/g, procyanidine 0.5-1.0
Mg/g, prepared rehmannia root polysaccharide 10-16mg/g, martynoside A 0.6-1.5mg/g, martynoside D 0.6-1.6mg/g, acteoside
0.5-1.5mg/g and Catalpol 0.4-7.2mg/g, preparation method are as follows：
Step 1：Chinese cassia tree and prepared rhizome of rehmannia are weighed, the wherein weight ratio of Chinese cassia tree and prepared rhizome of rehmannia is 1:（1~2）；
Step 2：Chinese cassia tree is cleaned, is crushed after drying, adds 5-8 times of weight concentration for 60-70% ethyl alcohol, when immersion 2-3 is small, reflux
It decocts, extracts 1-3 time, when each 1-2 is small, filtering, vacuum distillation removing ethyl alcohol, and be concentrated into 55-60 DEG C of relative density and be
1.20-1.25 concentrate, it is spare；
Step 3：Prepared rhizome of rehmannia is cleaned, is crushed after drying, adds in the purified water of 6-8 times of weight, reflux decocts 1-3 times, each 1-
3 it is small when, filtering, concentrate the filtrate to 55-60 DEG C of relative density be 1.20-1.25 concentrate, it is spare；
Step 4：The concentrate of step 2 and step 3 is merged up to Traditional Chinese medicine compound composition of the present invention.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108837082A (en) * | 2018-09-28 | 2018-11-20 | 九仙尊霍山石斛股份有限公司 | A kind of Traditional Chinese medicine compound composition of auxiliary hyperglycemic and preparation method thereof |
| CN110664865A (en) * | 2019-10-18 | 2020-01-10 | 中国林业科学研究院林产化学工业研究所 | Method for separating and preparing extract of cinnamon steaming oil residues and application of extract |
| CN115715779A (en) * | 2022-12-05 | 2023-02-28 | 广州中医药大学科技产业园有限公司 | Application of digitonin D in preparation of products for regulating PI3K-AKT pathway |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319289A (en) * | 2011-09-26 | 2012-01-18 | 江苏九寿堂生物制品有限公司 | Hyperglycemic Chinese medicinal composition comprising cinnamon polyphenol and the like and preparation method of hyperglycemic Chinese medicinal composition |
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2017
- 2017-12-13 CN CN201711331115.9A patent/CN108042643A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319289A (en) * | 2011-09-26 | 2012-01-18 | 江苏九寿堂生物制品有限公司 | Hyperglycemic Chinese medicinal composition comprising cinnamon polyphenol and the like and preparation method of hyperglycemic Chinese medicinal composition |
Non-Patent Citations (2)
| Title |
|---|
| 卢春连等: "肉桂降糖活性成分提取方法的研究", 《应用化工》 * |
| 吴金环等: "地黄与熟地黄对糖尿病小鼠血糖血脂的影响", 《中国实验方剂学杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108837082A (en) * | 2018-09-28 | 2018-11-20 | 九仙尊霍山石斛股份有限公司 | A kind of Traditional Chinese medicine compound composition of auxiliary hyperglycemic and preparation method thereof |
| CN110664865A (en) * | 2019-10-18 | 2020-01-10 | 中国林业科学研究院林产化学工业研究所 | Method for separating and preparing extract of cinnamon steaming oil residues and application of extract |
| CN115715779A (en) * | 2022-12-05 | 2023-02-28 | 广州中医药大学科技产业园有限公司 | Application of digitonin D in preparation of products for regulating PI3K-AKT pathway |
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Application publication date: 20180518 |