CN108042363B - Preparation system and method capable of detecting Chinese patent medicine tablets on line - Google Patents
Preparation system and method capable of detecting Chinese patent medicine tablets on line Download PDFInfo
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- CN108042363B CN108042363B CN201810042180.8A CN201810042180A CN108042363B CN 108042363 B CN108042363 B CN 108042363B CN 201810042180 A CN201810042180 A CN 201810042180A CN 108042363 B CN108042363 B CN 108042363B
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- 238000001069 Raman spectroscopy Methods 0.000 claims abstract description 88
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3563—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing solids; Preparation of samples therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
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- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of medicine preparation, and particularly relates to a system and a method for preparing Chinese patent medicine tablets capable of being detected on line. The device comprises a raw material mixing system, a tabletting system, a Raman detection system, a Fourier infrared detection system, a superposition system and a packaging system. The medicines are fully mixed and ground before being mixed, so that the nonuniformity of the medicines during preparation of tablets can be reduced; firstly, preparing the tablets into slices, performing Raman detection and Fourier infrared detection, and comparing the Raman detection and the Fourier infrared detection with the spectrum of the known qualified slices, so that the judgment precision and speed are greatly improved, and whether the slices contain enough effective components can be accurately judged; the detection accuracy is greatly improved by combining a Raman detection method and a Fourier infrared detection method; the qualified medicine is subjected to operations such as superposition and coating, so that the detection precision of the medicine is ensured, and the dosage of the medicine is not influenced.
Description
Technical Field
The invention belongs to the field of medicine preparation, particularly relates to a Chinese patent medicine tablet preparation system and method, and particularly relates to a Chinese patent medicine tablet preparation system and method capable of realizing online detection.
Background
The Chinese Patent Medicine Traditional Chinese Medicine Patent description takes Traditional Chinese medicines as raw materials, and is processed into various Traditional Chinese Medicine products of different dosage forms, including pills, powder, ointment and pills. Is the essence of an effective prescription created and summarized by medical scientists in the past generations of China through hundreds of medical practices.
The Tibetan medicine is a unique medicine system formed by long-term practice on the basis of widely absorbing and fusing theories of traditional Chinese medicine, Indian medicine and pharmacology, and the like, has thousands of years of history so far, and is one of the national medicines which are relatively complete and influential in China. The preparation of the Tibetan medicine into the Chinese patent medicine is an effective way for developing and utilizing the Tibetan medicine.
The Chinese medicinal composition comprises pill, powder, soft extract, pellet, tablet, granule, lozenge, colloid, hard capsule, soft capsule, syrup, mixture, medicated wine, tincture, distillate, injection, aerosol, plaster, pellicle, and suppository.
Because the components with drug effects in the Chinese patent medicine are different from the western medicine, and the components with treatment effects in the western medicine are chemically known components, the detection in the preparation process is simpler, and only the content detection of the chemical components with effects is needed. The Chinese patent medicine generally has more complex active components, the drug effect of the Chinese patent medicine is related to various factors, and the current detection means is difficult to effectively detect. Particularly, no particularly effective means exists for detection in the preparation process.
The patent application of application number 2014204428220 has designed a micro-raman spectroscopy appearance sample platform, has an open-ended recess body in the middle of the sample platform, and recess body upper portion border department is equipped with the horizontal turn-ups of rectangle, and the internal bottom of recess is equipped with a nut mount for the fixation nut, the effect that the sample platform can the up-and-down motion to reach the focus. The sample table is convenient to use, simple to operate and suitable for detecting tablets, but the detection is only limited to fixed position detection, and the Fourier infrared detection cannot be executed by adopting reflective detection.
The patent application No. 2015800007446 discloses an automatic tablet inspection device, wherein the tablet identified as defective by the inspection results of the upper side detection camera and the detection camera after inversion is discharged to a first defective tablet discharge box by compressed air, and the tablet is discharged to a normal tablet discharge box. The detection is only limited to appearance detection, and the detection of components cannot be realized, particularly effective components cannot be detected.
The patent application No. 201510678947.2 discloses a Chinese medicinal composition for treating dysmenorrhea, which can be made into decoction, pill, capsule or tablet, and has simple preparation method and easy industrialization. The detection is carried out by adopting a thin-layer chromatography, the detection method is simple, the specificity is strong, and the detection result is reliable. But the detection speed is slow, and online detection cannot be realized.
The Raman spectrum detection technology and the Fourier infrared spectrum detection technology are high-speed detection technologies for organic matters at present, and can compare a detected spectrum with an effective drug spectrum so as to judge whether a drug to be detected is an effective drug.
Disclosure of Invention
The invention overcomes the defects and designs a Chinese patent medicine tablet preparation system capable of detecting on line, which comprises a raw material mixing system, a tabletting system, a Raman detection system, a Fourier infrared detection system, a superposition system and a packaging system;
the raw material mixing system comprises a plurality of raw material barrels, a pulverizer and a mixer, wherein each raw material barrel is filled with a Chinese patent medicine preparation raw material which is a Chinese medicine powder or tablet preparation auxiliary material; the raw material barrels are respectively connected with inlets of the pulverizer, and the Chinese patent medicine preparation raw materials enter the pulverizer through the inlets of the pulverizer and are fully pulverized in the pulverizer; the pulverizer comprises a grinding roller and an oscillator, and can fully grind the Chinese patent medicine preparation raw materials and mix the raw materials in an oscillating way; the pulverizer is connected with a mixer, the mixer comprises a water inlet, and the ground Chinese patent medicine preparation raw materials enter the mixer and are mixed with water to form Chinese patent medicine preparation raw material paste;
the tablet pressing system is connected with an outlet of the mixer and is provided with a feeding port, an extrusion tray, a scraping plate and a pre-pressing plate, the Chinese patent medicine preparation raw material paste reaches the extrusion tray through the feeding port, the extrusion tray is provided with an array-shaped pre-pressing groove, the depth of the pre-pressing groove is 0.7-1mm, and the scraping plate is arranged above the extrusion tray and used for scraping the Chinese patent medicine preparation raw material paste exceeding the pre-pressing groove to one side; the prepressing press plate is arranged above the extrusion tray, a bulge corresponding to the prepressing groove on the extrusion tray is arranged on the prepressing press plate, the height of the bulge on the prepressing press plate is 0.2-0.5mm, and the bulge is used for pressing the Chinese patent medicine preparation raw material paste in the prepressing groove into a prepressing sheet;
the bottom of the extrusion tray groove is provided with an air blowing port, and the air blowing port can blow air to blow the pre-pressing sheet out of the groove;
the Raman detection system comprises a first laser, a Raman emission optical fiber, a Raman emission head, a Raman collection probe, a Raman collection optical fiber and a Raman spectrometer;
the Fourier infrared detection system comprises a second laser, an infrared emergent optical fiber, an infrared emergent head, an infrared collecting probe, an infrared collecting optical fiber and an infrared spectrometer;
the Chinese patent medicine tablet preparation system further comprises a computer and a hollow conveying belt, wherein the hollow conveying belt is composed of two parallel conveying belts, the Raman emission head and the infrared emission head are both arranged above the hollow conveying belt, the Raman collection probe and the infrared collection probe are arranged on the lower side of the hollow conveying belt, a first sliding block and a second sliding block which can transversely move are arranged at positions of the hollow conveying belt below the Raman emission head and the infrared emission head, and the first sliding block and the second sliding block are used for transversely moving to enable pre-pressed tablets to fall out of the hollow conveying belt when the pre-pressed tablets are unqualified in detection;
the first laser, the second laser, the Raman spectrometer, the infrared spectrometer, the first sliding block and the second sliding block are all connected with a computer; the computer is internally stored with Raman and infrared spectrum models of qualified prepressed tablets and judges whether the detected prepressed tablets are qualified or not according to the spectroscopic data of the Raman spectrometer and the infrared spectrometer; if the pre-pressing piece is unqualified, sending an instruction to the first sliding block and the second sliding block to enable the unqualified pre-pressing piece to slide down;
the stacking system comprises a stacking conveyor belt, a bonding spray head, a stacking groove and a stacking pressing plate, wherein the bonding spray head is arranged above the stacking conveyor belt and used for spraying a bonding agent to the pre-pressing sheet, and the bonding agent is an edible bonding agent; the tail end of the superposition conveyor belt is provided with a superposition groove, the superposition pressing plate is arranged above the superposition groove, and a bulge corresponding to the superposition groove is arranged on the superposition pressing plate; after entering the stacking groove through the stacking conveyor belt, the pre-pressing sheet is extruded by the stacking pressing plate to form stacked tablets;
the packaging system is provided with a coating machine and a packaging machine, the coating machine is used for coating the tablets, and the packaging machine is used for packaging and boxing the coated tablets.
The first laser is a helium-neon laser or an Nd: YAG laser, helium neon laser emission wavelength of 632.8nm, Nd: the emission wavelength of the YAG laser is 1064 nm; a focusing lens is arranged in the Raman emission head, the focal length of the focusing lens is 150-250mm, and an optical filter is arranged in front of the Raman collection probe;
a stray light shielding cover is arranged at the detection position of the Raman detection system, the appearance of the shielding cover is a cuboid, and the Raman emission head and the Raman collection probe are arranged inside the shielding cover;
the second laser is Nd: YAG laser, Nd: the emission wavelength of the YAG laser is 1064 nm; a focusing lens is arranged in the infrared emission head, the focal length of the focusing lens is 150-250mm, and an optical filter is arranged in front of the infrared collection probe;
a stray light shielding cover is arranged at the detection position of the infrared detection system, the shielding cover is cuboid in appearance, and the infrared emission head and the infrared collection probe are arranged inside the shielding cover; the depth of the overlapping groove is 3-4mm, and the height of the bulge on the overlapping pressing plate is 1-2 mm.
The stack tank bottom still is provided with heating drying device, dry heating device is connected with the computer, can control heating drying device's temperature through the computer, the heater is infrared heating pipe, and the infrared ray of infrared heating pipe transmission is aimed at stack tank bottom, to the even heating in stack tank.
The tablet preparation auxiliary materials comprise one or more of starch, powdered sugar, dextrin, lactose, microcrystalline cellulose or mannitol.
The invention further provides a method for preparing tablets by using the system, which is characterized by comprising the following steps:
1) mixing the raw materials; respectively adding the raw materials for preparing the Chinese patent medicine tablets into different raw material barrels, feeding the raw materials into a grinder through the raw material barrels, and fully grinding and oscillating in the grinder; the crushed and oscillated raw materials enter a mixer, water is added into the raw materials in the mixer, and the raw materials are fully stirred to form Chinese patent medicine preparation raw material paste;
2) preparing a pre-pressing sheet; the Chinese patent medicine preparation raw material paste flows out of the mixer and then enters a pre-pressing groove on the extrusion tray, the scraper plate moves to enable the Chinese patent medicine preparation raw material paste on the extrusion tray, which is higher than the pre-pressing groove, to be scraped to one side, the pre-pressing plate falls down to extrude the Chinese patent medicine preparation raw material paste in the pre-pressing groove, and the Chinese patent medicine preparation raw material paste is extruded into a flaky pre-pressing sheet;
3) optical detection; placing the prepressing pieces on the hollow conveying belt, wherein two sides of each prepressing piece are respectively loaded on the conveying belts on two sides of the hollow conveying belt; the prepressing piece passes below the Raman ejection head, the Raman ejection head emits Raman detection laser, the Raman detection laser passes through the prepressing piece and is collected by the Raman collection probe, the collected light enters the Raman spectrometer, the data of the Raman spectrometer is transmitted to the computer, and the computer judges whether the prepressing piece is qualified or not; if the pre-pressed sheet is qualified, entering the next procedure, and if the pre-pressed sheet is not qualified, sending an instruction to the first sliding block to enable the non-qualified pre-pressed sheet to slide down;
the prepressing piece passes below the infrared emitting head, the infrared emitting head emits infrared detection laser, the infrared detection laser passes through the prepressing piece and is collected by an infrared collecting probe, the collected light enters an infrared spectrometer, data of the infrared spectrometer are transmitted to a computer, and the computer judges whether the prepressing piece is qualified or not; if the pre-pressed sheet is qualified, entering the next procedure, and if the pre-pressed sheet is not qualified, sending an instruction to the first sliding block to enable the non-qualified pre-pressed sheet to slide down;
4) pre-tabletting and overlapping; the prepressing pieces which are qualified through detection are conveyed to a superposition conveyor belt, a bonding spray head sprays a bonding agent to the prepressing pieces, the prepressing pieces sprayed with the bonding agent enter a superposition groove, a plurality of prepressing pieces enter the superposition groove, a superposition pressing plate falls down, and the prepressing pieces are extruded by the superposition pressing plate to form tablets;
5) and (3) packaging tablets: and (4) coating the tablets by a coating machine, packaging the coated tablets by a packaging machine, and boxing.
The invention has the beneficial effects that:
1) the traditional Chinese medicine has different structures, and the medicines are fully mixed and ground before being mixed, so that the nonuniformity of the medicines during preparation of tablets can be reduced;
2) firstly, preparing the tablets into slices, performing Raman detection and Fourier infrared detection, and comparing the Raman detection and the Fourier infrared detection with the spectrum of the known qualified slices, so that the judgment precision and speed are greatly improved, and whether the slices contain enough effective components can be accurately judged;
3) the detection accuracy is greatly improved by combining a Raman detection method and a Fourier infrared detection method;
4) the qualified medicine is subjected to operations such as superposition and coating, so that the detection precision of the medicine is ensured, and the dosage of the medicine is not influenced.
Drawings
FIG. 1 is a schematic diagram of the system of the present invention;
FIG. 2 is a schematic structural view of a raw material mixing system according to the present invention;
FIG. 3 is a schematic diagram of a tabletting system according to the present invention;
FIG. 4 is a schematic structural diagram of a Raman detection system and a Fourier infrared detection system of the present invention;
FIG. 5 is a schematic diagram of the stacking system of the present invention.
Detailed Description
Example 1
This embodiment is specifically described for the apparatus of the present invention.
Referring to fig. 1-5, a system for preparing Chinese patent medicine tablets capable of on-line detection comprises a raw material mixing system 1, a tabletting system 2, a raman detection system 3, a fourier infrared detection system 4, a stacking system 5 and a packaging system 6;
the raw material mixing system 1 comprises a plurality of raw material barrels 101, a pulverizer 102 and a mixer 103, wherein each raw material barrel 101 is filled with a Chinese patent medicine preparation raw material which is a Chinese medicine powder or tablet preparation auxiliary material; the raw material barrels 101 are respectively connected with inlets of the pulverizer 102, and the Chinese patent medicine preparation raw materials enter the pulverizer 102 through the inlet of the pulverizer 102 and are sufficiently pulverized in the pulverizer 102; the pulverizer 102 is internally provided with a grinding roller and an oscillator, and can fully grind, oscillate and mix the Chinese patent medicine preparation raw materials; the pulverizer 102 is connected with a mixer 103, the mixer 103 comprises a water inlet, and the ground Chinese patent medicine preparation raw materials enter the mixer 103 and are mixed with water to form Chinese patent medicine preparation raw material paste;
the tabletting system 2 is connected with an outlet of the mixer 103, the tabletting system 2 is provided with a feeding port, an extrusion tray 201, a scraping plate and a pre-pressing plate 202, the Chinese patent medicine preparation raw material paste reaches the extrusion tray 201 through the feeding port, the extrusion tray 201 is provided with an array-shaped pre-pressing groove 203, the depth of the pre-pressing groove 203 is 0.7-1mm, and the scraping plate is arranged above the extrusion tray 201 and used for scraping the Chinese patent medicine preparation raw material paste exceeding the pre-pressing groove 203 to one side; the pre-pressing plate 202 is arranged above the extrusion tray 201, a bulge corresponding to the pre-pressing groove 203 on the extrusion tray 201 is arranged on the pre-pressing plate 202, the height of the bulge on the pre-pressing plate 202 is 0.2-0.5mm, and the bulge is used for pressing the Chinese patent medicine preparation raw material paste in the pre-pressing groove 203 into a pre-pressing sheet 701;
the bottom of the groove of the extrusion tray 201 is provided with an air blowing port 204, and the air blowing port 204 can blow air to blow the prepressing sheet 701 out of the groove;
the raman detection system 3 includes a first laser 301, a raman emission fiber 302, a raman emission head 303, a raman collection probe 306, a raman collection fiber 305, and a raman spectrometer 304;
the fourier infrared detection system 4 comprises a second laser 401, an infrared emitting optical fiber 402, an infrared emitting head 403, an infrared collecting probe 406, an infrared collecting optical fiber 405 and an infrared spectrometer 404;
the Chinese patent medicine tablet preparation system further comprises a computer 7 and a hollow conveyor belt 702, the hollow conveyor belt 702 is two parallel conveyor belts, the Raman emission head 303 and the infrared emission head 403 are both arranged above the hollow conveyor belt 702, the Raman collection probe 306 and the infrared collection probe 406 are arranged at the lower side of the hollow conveyor belt 702, a first slide block and a second slide block which can move transversely are arranged at positions of the hollow conveyor belt 702 below the Raman emission head 303 and the infrared emission head 403, and the first slide block and the second slide block are used for enabling the pre-pressing piece 701 to fall out of the hollow conveyor belt 702 when the pre-pressing piece 701 is unqualified in detection;
the first laser 301, the second laser 401, the raman spectrometer 304, the infrared spectrometer 404, the first slider and the second slider are all connected with the computer 7; the computer 7 stores the raman and infrared spectrum models of the qualified prepressing piece 701, and the computer 7 judges whether the detected prepressing piece 701 is qualified or not according to the light splitting data of the raman spectrometer 304 and the infrared spectrometer 404; if the pre-pressing piece is unqualified, sending an instruction to the first sliding block and the second sliding block to enable the unqualified pre-pressing piece 701 to slide down;
the stacking system 5 comprises a stacking conveyor belt 501, a bonding sprayer 502, a stacking groove 503 and a stacking press plate 504, wherein the bonding sprayer 502 is arranged above the stacking conveyor belt 501 and is used for spraying a bonding agent to the pre-pressing sheet 701, and the bonding agent is an edible bonding agent; the tail end of the overlapping conveyor belt 501 is provided with an overlapping groove 503, an overlapping pressing plate 504 is arranged above the overlapping groove 503, and a protrusion corresponding to the overlapping groove 503 is arranged on the overlapping pressing plate 504; after entering the overlapping groove 503 through the overlapping conveyor belt 501, the pre-tabletting 701 is extruded by the overlapping press plate 504 to form overlapped tablets;
the packaging system 6 is provided with a coating machine and a packaging machine, the coating machine is used for coating the tablets, and the packaging machine is used for packaging and boxing the coated tablets.
The first laser is a helium-neon laser or an Nd: YAG laser, helium neon laser emission wavelength of 632.8nm, Nd: the emission wavelength of the YAG laser is 1064 nm; a focusing lens is arranged in the Raman emission head, the focal length of the focusing lens is 150-250mm, and an optical filter is arranged in front of the Raman collection probe;
a stray light shielding cover is arranged at the detection position of the Raman detection system, the appearance of the shielding cover is a cuboid, and the Raman emission head and the Raman collection probe are arranged inside the shielding cover;
the second laser is Nd: YAG laser, Nd: the emission wavelength of the YAG laser is 1064 nm; a focusing lens is arranged in the infrared emission head, the focal length of the focusing lens is 150-250mm, and an optical filter is arranged in front of the infrared collection probe;
a stray light shielding cover is arranged at the detection position of the infrared detection system, the shielding cover is cuboid in appearance, and the infrared emission head and the infrared collection probe are arranged inside the shielding cover;
the depth of the overlapping groove is 3-4mm, and the height of the bulge on the overlapping pressing plate is 1-2 mm.
The stack tank bottom still is provided with heating drying device, dry heating device is connected with the computer, can control heating drying device's temperature through the computer, the heater is infrared heating pipe, and the infrared ray of infrared heating pipe transmission is aimed at stack tank bottom, to the even heating in stack tank.
The tablet preparation auxiliary materials comprise one or more of starch, powdered sugar, dextrin, lactose, microcrystalline cellulose or mannitol.
Example 2
This example is mainly specifically described with respect to the method of preparing the device of example 1.
The method comprises the following steps:
1) mixing the raw materials; the raw materials required for preparing the Chinese patent medicine tablets are respectively added into different raw material barrels 101, the raw materials enter a grinder 102 through the raw material barrels 101, and are fully ground and oscillated in the grinder 102; the crushed and oscillated raw materials enter a mixer 103, and the raw materials are added with water in the mixer 103 and fully stirred to form Chinese patent medicine preparation raw material paste;
2) preparing a pre-tabletting 701; the Chinese patent medicine preparation raw material paste flows out of the mixer 103 and then enters the pre-pressing groove 203 on the extrusion tray 201, the scraper plate moves to enable the Chinese patent medicine preparation raw material paste on the extrusion tray 201, which is higher than the pre-pressing groove 203, to be scraped to one side, the pre-pressing plate 202 falls down to extrude the Chinese patent medicine preparation raw material paste in the pre-pressing groove 203, and the Chinese patent medicine preparation raw material paste is extruded into a sheet-shaped pre-pressing sheet 701;
3) optical detection; placing the pre-pressing piece 701 on a hollow conveyor belt 702, wherein two sides of the pre-pressing piece 701 are respectively loaded on the conveyor belts on two sides of the hollow conveyor belt 702; the pre-pressing sheet 701 passes below the Raman emission head 303, the Raman emission head 303 emits Raman detection laser, the Raman detection laser passes through the pre-pressing sheet 701 and is collected by the Raman collection probe 306, the collected light enters the Raman spectrometer 304, data of the Raman spectrometer 304 are transmitted to the computer 7, and the computer 7 judges whether the pre-pressing sheet 701 is qualified or not; if the pre-pressing sheet is qualified, the next procedure is carried out, and if the pre-pressing sheet is not qualified, an instruction is sent to the first sliding block, so that the non-qualified pre-pressing sheet 701 slides down;
the pre-pressing sheet 701 passes below the infrared emitting head 403, the infrared emitting head 403 emits infrared detection laser, the infrared detection laser passes through the pre-pressing sheet 701 and is collected by the infrared collecting probe 406, the collected light enters the infrared spectrometer 404, data of the infrared spectrometer 404 are transmitted to the computer 7, and the computer 7 judges whether the pre-pressing sheet 701 is qualified; if the pre-pressing sheet is qualified, the next procedure is carried out, and if the pre-pressing sheet is not qualified, an instruction is sent to the first sliding block, so that the non-qualified pre-pressing sheet 701 slides down;
4) overlapping the preforming sheets 701; the prepressed sheets 701 qualified through detection are conveyed to a superposition conveyor belt 501, the bonding sprayer 502 sprays a bonding agent to the prepressed sheets 701, the prepressed sheets 701 sprayed with the bonding agent enter a superposition groove 503, after a plurality of prepressed sheets 701 enter the superposition groove 503, a superposition pressing plate 504 falls, and the prepressed sheets 701 form tablets under the extrusion of the superposition pressing plate 504;
5) and (3) packaging tablets: and (4) coating the tablets by a coating machine, packaging the coated tablets by a packaging machine, and boxing.
Example 3
The following description will be made for the preparation of specific Chinese patent drugs.
The preparation method of the compound salvia tablet comprises the following steps:
the raw materials for preparation are salvia miltiorrhiza, panax notoginseng, borneol and auxiliary starch.
1) Mixing the raw materials; respectively adding radix Salviae Miltiorrhizae, radix Notoginseng, Borneolum Syntheticum and starch as adjuvant into different material barrels 101, allowing the raw materials to pass through the material barrels 101 and enter a pulverizer 102, and pulverizing and oscillating in the pulverizer 102; the crushed and oscillated raw materials enter a mixer 103, and the raw materials are added with water in the mixer 103 and fully stirred to form Chinese patent medicine preparation raw material paste;
2) preparing a pre-tabletting 701; the Chinese patent medicine preparation raw material paste flows out of the mixer 103 and then enters the pre-pressing groove 203 on the extrusion tray 201, the scraper plate moves to enable the Chinese patent medicine preparation raw material paste on the extrusion tray 201, which is higher than the pre-pressing groove 203, to be scraped to one side, the pre-pressing plate 202 falls down to extrude the Chinese patent medicine preparation raw material paste in the pre-pressing groove 203, and the Chinese patent medicine preparation raw material paste is extruded into a sheet-shaped pre-pressing sheet 701;
3) optical detection; preselecting the Raman spectrum and the Fourier spectrum of the prepressured tablet of the qualified compound salvia tablet in a computer, and forming a detection model;
placing the pre-pressing piece 701 on a hollow conveyor belt 702, wherein two sides of the pre-pressing piece 701 are respectively loaded on the conveyor belts on two sides of the hollow conveyor belt 702; the pre-pressing sheet 701 passes below the Raman emission head 303, the Raman emission head 303 emits Raman detection laser, the Raman detection laser passes through the pre-pressing sheet 701 and is collected by the Raman collection probe 306, the collected light enters the Raman spectrometer 304, data of the Raman spectrometer 304 are transmitted to the computer 7, and the computer 7 judges whether the pre-pressing sheet 701 is qualified or not; if the pre-pressing sheet is qualified, the next procedure is carried out, and if the pre-pressing sheet is not qualified, an instruction is sent to the first sliding block, so that the non-qualified pre-pressing sheet 701 slides down;
the pre-pressing sheet 701 passes below the infrared emitting head 403, the infrared emitting head 403 emits infrared detection laser, the infrared detection laser passes through the pre-pressing sheet 701 and is collected by the infrared collecting probe 406, the collected light enters the infrared spectrometer 404, data of the infrared spectrometer 404 are transmitted to the computer 7, and the computer 7 judges whether the pre-pressing sheet 701 is qualified; if the pre-pressing sheet is qualified, the next procedure is carried out, and if the pre-pressing sheet is not qualified, an instruction is sent to the first sliding block, so that the non-qualified pre-pressing sheet 701 slides down;
4) overlapping the preforming sheets 701; the prepressed sheets 701 qualified through detection are conveyed to a superposition conveyor belt 501, the bonding sprayer 502 sprays a bonding agent to the prepressed sheets 701, the prepressed sheets 701 sprayed with the bonding agent enter a superposition groove 503, after a plurality of prepressed sheets 701 enter the superposition groove 503, a superposition pressing plate 504 falls, and the prepressed sheets 701 form tablets under the extrusion of the superposition pressing plate 504;
5) and (3) packaging tablets: coating the tablets by a coating machine, packaging the coated compound salvia tablets by a packaging machine, and boxing.
Claims (4)
1. A Chinese patent medicine tablet preparation system capable of detecting on line comprises a raw material mixing system (1), a tabletting system (2), a Raman detection system (3), a Fourier infrared detection system (4), a superposition system (5) and a packaging system (6);
the raw material mixing system (1) comprises a plurality of raw material barrels (101), a pulverizer (102) and a mixer (103), wherein each raw material barrel (101) is filled with a Chinese patent medicine preparation raw material which is a Chinese medicine powder or tablet preparation auxiliary material; the raw material barrels (101) are respectively connected with inlets of the pulverizer (102), and the Chinese patent medicine preparation raw materials enter the pulverizer (102) through the inlets of the pulverizer (102) and are sufficiently pulverized in the pulverizer (102); the pulverizer (102) is internally provided with a grinding roller and an oscillator, and can fully grind, oscillate and mix the Chinese patent medicine preparation raw materials; the pulverizer (102) is connected with a mixer (103), the mixer (103) comprises a water inlet, and the ground Chinese patent medicine preparation raw materials enter the mixer (103) and are mixed with water to form Chinese patent medicine preparation raw material paste;
the tablet pressing system (2) is connected with an outlet of the mixer (103), the tablet pressing system (2) is provided with a feeding port, an extrusion tray (201), a scraper blade and a pre-pressing plate (202), the Chinese patent medicine preparation raw material paste reaches the extrusion tray (201) through the feeding port, the extrusion tray (201) is provided with an array-shaped pre-pressing groove (203), the depth of the pre-pressing groove (203) is 0.7-1mm, and the scraper blade is arranged above the extrusion tray (201) and used for scraping the Chinese patent medicine preparation raw material paste exceeding the pre-pressing groove (203) to one side; the prepressing plate (202) is arranged above the extrusion tray (201), a bulge corresponding to the prepressing groove (203) on the extrusion tray (201) is arranged on the prepressing plate (202), the height of the bulge on the prepressing plate (202) is 0.2-0.5mm, and the bulge is used for pressing the Chinese patent medicine preparation raw material paste in the prepressing groove (203) into a prepressing sheet (701);
the bottom of the groove of the extrusion tray (201) is provided with an air blowing port (204), and the air blowing port (204) can blow air to blow the prepressing sheet (701) out of the groove;
the Raman detection system (3) comprises a first laser (301), a Raman emission optical fiber (302), a Raman emission head (303), a Raman collection probe (306), a Raman collection optical fiber (305) and a Raman spectrometer (304);
the Fourier infrared detection system (4) comprises a second laser (401), an infrared emergent optical fiber (402), an infrared emergent head (403), an infrared collecting probe (406), an infrared collecting optical fiber (405) and an infrared spectrometer (404);
the Chinese patent medicine tablet preparation system further comprises a computer (7) and a hollow conveyor belt (702), the hollow conveyor belt (702) is two parallel conveyor belts, the Raman emission head (303) and the infrared emission head (403) are arranged above the hollow conveyor belt (702), the Raman collection probe (306) and the infrared collection probe (406) are arranged on the lower side of the hollow conveyor belt (702), a first slide block and a second slide block which can move transversely are arranged at positions of the hollow conveyor belt (702) below the Raman emission head (303) and the infrared emission head (403), and the first slide block and the second slide block are used for enabling the prepressure sheet (701) to fall out of the hollow conveyor belt (702) through transverse movement when the prepressure sheet (701) is detected to be unqualified;
the first laser (301), the second laser (401), the Raman spectrometer (304), the infrared spectrometer (404), the first sliding block and the second sliding block are all connected with a computer (7); the computer (7) is internally provided with Raman and infrared spectrum models of the qualified prepressure sheet (701), the computer (7) judges whether the detected prepressure sheet (701) is qualified or not according to the light splitting data of the Raman spectrometer (304) and the infrared spectrometer (404), carries out Raman detection and Fourier infrared detection, compares the spectrum with the spectrum of the known qualified sheet and judges whether the prepressure sheet (701) contains enough effective components or not;
if the pre-pressing sheet is unqualified, sending an instruction to the first sliding block and the second sliding block to enable the unqualified pre-pressing sheet (701) to slide down;
the stacking system (5) comprises a stacking conveyor belt (501), a bonding spray head (502), a stacking groove (503) and a stacking pressing plate (504), wherein the bonding spray head (502) is arranged above the stacking conveyor belt (501) and is used for spraying a bonding agent to the pre-pressing sheet (701), and the bonding agent is an edible bonding agent; the tail end of the overlapping conveyor belt (501) is provided with an overlapping groove (503), an overlapping pressing plate (504) is arranged above the overlapping groove (503), and a bulge corresponding to the overlapping groove (503) is arranged on the overlapping pressing plate (504); the pre-pressing sheet (701) enters an overlapping groove (503) through an overlapping conveyor belt (501), and then is extruded by an overlapping pressing plate (504) to form an overlapping tablet;
the packaging system (6) is provided with a coating machine and a packaging machine, the coating machine is used for coating the tablets, and the packaging machine is used for packaging and boxing the tablets after coating.
2. The on-line detectable Chinese patent medicine tablet preparation system of claim 1, wherein:
the first laser (301) is a helium-neon laser or Nd: YAG laser, helium neon laser emission wavelength of 632.8nm, Nd: the emission wavelength of the YAG laser is 1064 nm; a focusing lens is arranged in the Raman emission head, the focal length of the focusing lens is 150-250mm, and an optical filter is arranged in front of the Raman collection probe;
a stray light shielding cover is arranged at the detection position of the Raman detection system, the appearance of the shielding cover is a cuboid, and the Raman emission head (303) and the Raman collection probe (306) are arranged inside the shielding cover;
the depth of the overlapping groove (503) is 3-4mm, and the height of the protrusion on the overlapping pressing plate (504) is 1-2 mm.
3. The on-line detectable Chinese patent medicine tablet preparation system of claim 2, wherein: the tablet preparation auxiliary materials comprise one or more of starch, powdered sugar, dextrin, lactose, microcrystalline cellulose or mannitol;
the bottom of the overlapping groove (503) is also provided with a heating and drying device, the drying and heating device is connected with a computer, the temperature of the heating and drying device can be controlled by the computer, the heater is an infrared heating pipe, and infrared rays emitted by the infrared heating pipe are aligned to the bottom of the overlapping groove to uniformly heat the overlapping groove.
4. A method of tablet preparation using the system of claim 3, characterized by the steps of:
1) mixing the raw materials; the raw materials required for preparing the Chinese patent medicine tablets are respectively added into different raw material barrels (101), the raw materials enter a grinder (102) through the raw material barrels (101), and are fully ground and oscillated in the grinder (102); the crushed and oscillated raw materials enter a mixer (103), the raw materials are added with water in the mixer (103), and the raw materials are fully stirred to form Chinese patent medicine preparation raw material paste;
2) preparing a preforming sheet (701); the Chinese patent medicine preparation raw material paste flows out of the mixer (103) and then enters a prepressing groove (203) on the extrusion tray (201), the scraper plate moves to enable the Chinese patent medicine preparation raw material paste on the extrusion tray (201) and higher than the prepressing groove (203) to be scraped to one side, the prepressing pressing plate (202) falls down, the Chinese patent medicine preparation raw material paste in the prepressing groove (203) is extruded, and the Chinese patent medicine preparation raw material paste is extruded into a flaky prepressing sheet (701);
3) optical detection; placing the preforming sheet (701) on the hollow conveyor belt (702), wherein two sides of the preforming sheet (701) are respectively loaded on the conveyor belts on two sides of the hollow conveyor belt (702); the pre-pressing sheet (701) passes below the Raman emission head (303), the Raman emission head (303) emits Raman detection laser, the Raman detection laser passes through the pre-pressing sheet (701) and is collected by the Raman collection probe (306), the collected light enters the Raman spectrometer (304), data of the Raman spectrometer (304) are transmitted to the computer (7), and the computer (7) judges whether the pre-pressing sheet (701) is qualified or not; if the pre-pressing sheet is qualified, entering the next procedure, and if the pre-pressing sheet is not qualified, sending an instruction to the first sliding block to enable the non-qualified pre-pressing sheet (701) to slide;
the prepressing sheet (701) passes below the infrared emission head (403), the infrared emission head (403) emits infrared detection laser, the infrared detection laser passes through the prepressing sheet (701) and is collected by an infrared collection probe (406), the collected light enters an infrared spectrometer (404), data of the infrared spectrometer (404) are transmitted to a computer (7), and the computer (7) judges whether the prepressing sheet (701) is qualified or not; if the pre-pressing sheet is qualified, entering the next procedure, and if the pre-pressing sheet is not qualified, sending an instruction to the first sliding block to enable the non-qualified pre-pressing sheet (701) to slide;
4) overlapping the preforming sheets (701); the prepressed pieces (701) which are qualified through detection are conveyed to a superposition conveyor belt (501), a bonding spray head (502) sprays bonding agents to the prepressed pieces (701), the prepressed pieces (701) sprayed with the bonding agents enter a superposition groove (503), a plurality of prepressed pieces (701) fall down after entering the superposition groove (503), and a plurality of prepressed pieces (701) form tablets under the extrusion of the superposition pressing plate (504);
5) and (3) packaging tablets: and (4) coating the tablets by a coating machine, packaging the coated tablets by a packaging machine, and boxing.
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| SE9802537D0 (en) * | 1998-07-13 | 1998-07-13 | Astra Ab | Method of controlling a coating process |
| FR2855756B1 (en) * | 2003-06-06 | 2005-08-26 | Ethypharm Sa | MULTILAYER ORODISPERSIBLE TABLET |
| CA2630248C (en) * | 2005-11-18 | 2015-01-13 | Glaxo Group Limited | Machine and method for pharmaceutical and pharmaceutical-like product assembly |
| US8691272B2 (en) * | 2005-12-30 | 2014-04-08 | Intelgenx Corp. | Multilayer tablet |
| US20110037185A1 (en) * | 2008-04-30 | 2011-02-17 | James Kowalski | Continuous process for making pharmaceutical compositions |
| CN101620178B (en) * | 2009-06-19 | 2011-02-16 | 广东省药品检验所 | Method for quickly detecting additive chemical component in Chinese patent medicine, health-care food or food based on near-infrared spectrum technique |
| CN104856880B (en) * | 2015-05-07 | 2018-05-29 | 丹东金丸集团有限公司 | tablet filling device |
| US10365229B2 (en) * | 2015-12-31 | 2019-07-30 | Kaiser Optical Systems, Inc. | Real-time characterization of pharmaceutical tablet coatings using Raman spectroscopy |
| CN105699323A (en) * | 2016-03-08 | 2016-06-22 | 中国科学院合肥物质科学研究院 | Drug detection system based on Fourier transform NIRSA (near infrared spectroscopy analysis) technology |
| CN106109245A (en) * | 2016-08-16 | 2016-11-16 | 华南农业大学 | Cancer therapy drug that a kind of 3D of employing printing technique prepares and method |
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