CN108034562A - A kind of Siberian solomonseal rhizome health-care vinegar and its preparation method and application - Google Patents
A kind of Siberian solomonseal rhizome health-care vinegar and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of Siberian solomonseal rhizome health-care vinegar and its preparation method and application.The Siberian solomonseal rhizome health-care vinegar is mainly made of the fermenting raw materials of following parts by weight, 40~85 parts of sealwort, 20~68 parts of Fructus psidii guajavae immaturus, 1~25 part of brown sugar.Health-care vinegar provided by the invention can substantially reduce diabetes blood glucose, with replenish qi to invigorate the spleen, enriching yin is quenched one's thirst, the polydipsia of diabetes patient is drunk more, the symptom such as gluttony of becoming thin, body are become thin, fatigue is weak, the lazy speech of shortness of breath, lustreless complexion is significantly improved, long-term use of to prevent, alleviate, treat hyperglycaemia.Health-care vinegar has clear, in faint yellow or brown color, has strong fruity and vinegar perfume, tart flavour is soft, without other obvious peculiar smell.Health-care vinegar provided by the invention has special effect, and Small side effects, no toxicity, can prevent, alleviates, treat hyperglycaemia, tool has a better effect.
Description
Technical field
The invention belongs to health-care vinegar technical field, more particularly to a kind of Siberian solomonseal rhizome health-care vinegar and its preparation method and application.
Background technology
It is global at present as lifestyle change and operating pressure increase, diabetic just increase with surprising rapidity
Diabetic's quantity alreadys exceed 200,000,000, it is contemplated that will exceed 300,000,000 within 2025, diabetes have become and cardiovascular and cerebrovascular, tumour phase
One of three serious diseases of serious harm human health arranged side by side, have more and more researchers to be directed to hypoglycemic mechanism and peace at present
Stable hypoglycemic medicine exploitation entirely.
Diabetes spp is damaged in beta Cell of islet, is caused caused by hypoinsulinism, i.e., it is main to treat diabetes
Therapy mechanism for protection beta Cell of islet, promote insulin secretion.Ancient Times in China traditional medicine is early recognized diabetes, sugar
Urine disease belongs to " diabete " category,《Interior warp》According to the primary and secondary of card, and it is classified as upper, middle and lower three and disappears, such as " the lung person of disappearing, drink one is urinated
Two " (《Element is the same as opinion of losing consciousness》), i.e., on disappear；" pathogenic heat in the stomach then disappear paddy, make us gluttony of being on tenterhooks " (《Ling Shu Miraculous Pivot or Divine Axis is a disciple of》), i.e., in disappear；
" liver arteries and veins ... kidney arteries and veins ... is small for the illness that disappears " (《Ling Shu Miraculous Pivot or Divine Axis perverse trend cacosplanchnia shape》), i.e., disappear down.Up to Song Yuan periods, " three disappear "
Theory gradually forms.Liu's interchannel of Jin and Yuan dynasty, Zhang Zi and waiting has developed three and has disappeared theory, advocates three and disappears scorching theory.
The understanding of blanket ancient Chinese medicine doctor, diabete be by physical factors in addition intemperance of taking food, disorder of emotion, high year overstrain,
Caused by diseases caused by external factors cult poison or medicine food such as hinder at the Different types of etiopathogenises, interior thermal burn the moon is its sill pathogenic characteristic, to drink more, eat, diuresis or
Urinate pleasantly sweet, tired few power or become thin as classical symptom.Interior hot yin-damaging and Qi consuming, can yin deficiency affecting yang, cause people it is deficient；Positive unsaturated vapor,
Easily by raw cult poison in exopathogen, or the deficiency of Yin, variable raw consumptive disease is coughed, stranguria with turbid discharge, sore carbuncle, tinea miliaria；The deficiency of Yin is scorching, or the turbid poison of interior life, liquid exhaust sun
De-, variable life is vomitted against de- acute disease of fainting；Pathogen usually intruding into collateral in protracted disease, channels stasis, can more cause chest impediment and cardialgia, apoplexy, oedema, obstruction and rejection, depending on looking forward or upwards
A variety of secondary conditions such as the confused vast, gangrene of finger or toe.
The rhizome of modern study table sealwort contains lymphatic temperament, starch and sugar, rhizome -2- containing azetidine carboxylic acids of P. cyrtonema
(Azetidine-2-carboxylicacid), asparatate (Asparticacid), homoserine (Homoserine), two
Aminobutyric acid (Diaminobutyricacid), digitalis glucoside (Digitalisglycoside) and a variety of Anthraquinones chemical combination
Thing.Sealwort has anti anoxia, antifatigue, anti-aging effects；Immune function, enhancing metabolism can be strengthened；Have hypoglycemic and strong
The heart acts on.China's Guava Leaf useful always among the people dries the classical prescription for the treatment of diabetes, and clinical test shows that Guava Leaf extracts
Thing has obvious hypoglycemic effect.In clinical practice and animal experiment study, using Guava Leaf, fruit, fruit juice and other
Herbal medicine assembles treatment diabetes and also achieves significant curative effect.Flavones containing guava, araban (arabinan) etc. in guava immature fruit
Polysaccharide, guava tan are plain (arabinose ester hexahydroxydiphenic acid), be hexa methoxy diphenic acid with
Arabopyranose is combined into.Modern research shows that guava immature fruit can soften blood vessel, reducing blood lipid and blood glucose, cholesterol is reduced.
The Chinese patent application of CN201410420337.8 discloses a kind of Chinese medicine composition for being used to treat diabetes, by
Dish cucurbit, sunflower disk, vinegar black soya bean, Poria cocos, balsam pear slice, pueraria lobata, guava, sealwort, ginger, radix astragali, glutinous rehmannia, the root bark of Chinese wolf-berry, Huang
Company, the root bark of white mulberry, Chinese gall, radix scrophulariae, rhizoma anemarrhenae, mulberry fruit, honey-fried licorice root, the achene of Siberian cocklebur and alum composition, the vinegar black soya bean is black soya bean
Obtained after being soaked 2-3 days in vinegar after cleaning.Although prepared in the patent using two kinds of medicinal materials of guava and sealwort hypoglycemic
Medicine, but need to coordinate other a variety of medicinal materials to can be only achieved blood sugar decreasing effect, should if used only with guava and sealwort
The method of patent prepares hypoglycemic drug, and curative effect is unsatisfactory.
The content of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of Siberian solomonseal rhizome health-care vinegar and its preparation method and application, the present invention
The Siberian solomonseal rhizome health-care vinegar special effect of offer, it is convenient to take, hyperglycaemia, no toxicity can be treated.
First aspect present invention, there is provided a kind of Siberian solomonseal rhizome health-care vinegar, the Siberian solomonseal rhizome health-care vinegar is mainly by the original of following parts by weight
Material fermentation is made：40~85 parts of sealwort, 20~68 parts of Fructus psidii guajavae immaturus, 1~25 part of brown sugar.
Preferably, 50~70 parts of the sealwort, 30~50 parts of Fructus psidii guajavae immaturus, 2~18 parts of brown sugar.
Further, the physical and chemical index of the health-care vinegar is as follows：With acetometer, total acid is not less than 3g/100ml；With grape
Sugar meter, content of reducing sugar are less than 1g/100mL；Total reducing sugar is not less than 8g/100mL；Alcoholic strength is less than 0.2 (v/v), general flavone content
More than 15mg/100mL, Siberian solomonseal rhizome polysaccharide content is more than 60mg/mL.
Second aspect of the present invention, there is provided the preparation method of the Siberian solomonseal rhizome health-care vinegar, the preparation method operation are as follows：By weight
Amount is made into suspension, suspension is through Aspergillus batatae than being decocted after weighing sealwort and guava dry plate immersion with brown sugar after cooling
(AS3324) wheat bran distiller's yeast and fragrant yeast carry out alcoholic fermentation, carry out acetic fermentation, filtering through acetic acid saccharomycete again, post-treated
Obtain Siberian solomonseal rhizome health-care vinegar.
Further, the suspension configuration process is as follows：Dry root section and Fructus psidii guajavae immaturus by sealwort divide after cleaning
Not crushing, add water to reach every milliliter and contain 0.1~1 gram of sealwort and Pan Shiliu, after medicinal material immersion, heating stirring decocts 30-150min,
Brown sugar is added after being cooled to 30~50 DEG C, sugar addition to 20-25%, adjusts pH value to 3-5, obtain suspension.
Further, the alcoholic fermentation process is as follows：Suspension is cooled to 28-35 DEG C, access 5-15%'s (w/w)
Aspergillus batatae (AS3324) wheat bran distiller's yeast, and the fragrant yeast for accounting for wheat bran yeast 15~25% (w/w) is added, carried out after fully mixing
Fermentation, fermentation temperature are controlled at 15-20 DEG C, and cane sugar content in mash is made and obtains distiller's wort less than 1.5g/100ml fermentation ends.
Further, the acetic fermentation process is as follows：1.01 saccharomycete are made in the Shanghai that 2-5% is added in distiller's wort, and stirring is equal
It is even, temperature control at 32~35 DEG C, fermentation 60-80 it is small when, alcohol content drops to 0.4~0.6%, ferment to total acidity 5~
7%, stop acetic fermentation and obtain vinegar wine with dregs.
Further, the last handling process is as follows：1-2% edible salts are added into the vinegar wine with dregs after fermentation, are stirred evenly,
The white bole of 7-9% and the polyvinyl lactam of 0.15-0.25% are added, is stirred evenly, after closed static 10-15 days carry out
It is ripe, the vinegar liquid of after-ripening is repeatedly filtered to clear, fermented vinegar is made, by fermented vinegar sealing and standing ageing more than 10 days；Survey
Determine the acetic acid content of ageing, add water to convert to acetic acid content to 3-5%, up to Siberian solomonseal rhizome health-care vinegar.
Third aspect present invention, there is provided application of the Siberian solomonseal rhizome health-care vinegar in prevention, treatment hyperglycemia medicine is prepared.
One of innovative point of the present invention is that the present invention is compounded using sealwort, Fructus psidii guajavae immaturus and brown sugar, through corresponding
Distiller's yeast and saccharomycetes to make fermentation form health-care vinegar.Can be by the Siberian solomonseal rhizome polysaccharide in sealwort and kind stone using the method for microbial fermentation
Pomegranate flavones content is higher, and two kinds of medicinal materials are made health-care vinegar, and the active ingredient of sealwort and Fructus psidii guajavae immaturus can be sent out in vinegar
Wave the drug effect of maximum.Use microbial fermentation in sour environment, guava flavones and the common extracting method of Siberian solomonseal rhizome polysaccharide ratio
Recovery rate increases significantly.Experiment shows Siberian solomonseal rhizome polysaccharide to the Huang in streptozotocin diabetes rat hypoglycemic effect, Fructus psidii guajavae immaturus
Ketone can promote insulin secretion.
The two of the innovative point of the present invention are, compared with other distiller's yeasts and yeast, Aspergillus batatae (AS3324) wheat bran distiller's yeast
Other materials such as starch and the albumen in sealwort and guava can be fully decomposed with fragrant yeast, so that release is yellow to greatest extent
The content of Siberian solomonseal rhizome polysaccharide and guava flavones in essence.Present invention discover that using Aspergillus batatae (AS3324) wheat bran distiller's yeast and fragrant ferment
Mother is used for combined ferment, microorganism well-grown in fermentation system, and other microorganisms for example brevibacterium, bacillus subtilis,
Bacillus fusiformis, distillery yeast are slow-growing when fermenting in above-mentioned fermentation system, even if ferment effect is still unknown after domestication
Aobvious, guess is that some components in medicinal material suppress growth of microorganism and have impact on course of fermentation.Aspergillus batatae (AS3324) wheat bran
The content of Siberian solomonseal rhizome polysaccharide and guava flavones is significantly larger than other microbial fermentations in distiller's wort after distiller's yeast and fragrant yeast fermentation,
The active constituent content in health-care vinegar is improved, and then improves drug effect, it is not necessary to is compounded with other drugs with regard to ratio can be played
The effect of Chinese medicine composition bigger.
Compared with prior art, the invention has the advantages that：The present invention is only protected using sealwort and Pan Shiliu fermentations
Strong vinegar, compounds hypoglycemic effect, cost of the present invention is relatively low, special effect, the without side-effects, side of taking with regard to that can reach multi-medicament
Just, have no toxic side effect.
Brief description of the drawings
Fig. 1 is influence of the pH value to Siberian solomonseal rhizome polysaccharide content；
Fig. 2 is influence of the pH value to general flavone content.
Embodiment
Technical scheme is described in further details with reference to specific embodiment, the invention is not limited in
Following technical scheme.
1 sealwort fermenting microbe of embodiment selects
Sealwort 500g is weighed, is crushed as coarse powder, adds 1L drinking water to soak 2h, boiling reflux 2h, adds after being cooled to 30 DEG C
Brown sugar, sugar addition to 25%, adjusts pH value to 3.5~4.2,10 kinds of microorganisms is respectively adopted and carry out alcoholic fermentation.Ferment bar
Part is as follows：Microbial inoculant amount is 15% (w/w), and fermentation temperature is controlled at 18-20 DEG C, and cane sugar content in mash is made and is less than
1.5g/100mL fermentation ends obtain distiller's wort, then carry out acetic fermentation again and obtain Siberian solomonseal rhizome health-care vinegar.
Using anthrone-concentrated sulfuric acid colorimetric determination analysis Siberian solomonseal rhizome polysaccharide：It is accurate after mash filtrations to draw appropriate vinegar liquid, add pure
For water to 2mL, precision is slowly added to 0.2% anthrone-concentrated sulfuric acid solution 4mL, and shaking mixes, static 1h, only with brown sugar, not adopt
The mash to be fermented by the use of sealwort is used as blank control.Siberian solomonseal rhizome polysaccharide at 625nm after anthrone-strong sulfuric acid response with having absorption maximum
Peak, quantitative analysis carry out at that wavelength, after drawing standard curve, then measure Siberian solomonseal rhizome polysaccharide content in mash.10 kinds of microorganisms
Species and alcohol in Siberian solomonseal rhizome polysaccharide content it is as shown in table 1.
Table 1
As shown in Table 1, the fermentation of sealwort brown sugar solution, obtained Huang are carried out using Aspergillus batatae (AS3324) wheat bran distiller's yeast
Smart polyoses content highest.
2 guava fermenting microbe of embodiment selects
Fructus psidii guajavae immaturus 500g is weighed, is crushed as coarse powder, adds 1L drinking water to soak 2h, boiling reflux 2h, after being cooled to 30 DEG C
Brown sugar is added, sugar addition to 25%, adjusts pH value to 3.5~4.2,10 kinds of microorganisms are respectively adopted and carry out alcoholic fermentation.Hair
Ferment condition is as follows：Microbial inoculant amount is 15% (w/w), and fermentation temperature is controlled at 18-20 DEG C, and it is few that cane sugar content in mash is made
Distiller's wort is obtained in 1.5g/100ml fermentation ends, acetic fermentation is then carried out again and obtains Siberian solomonseal rhizome health-care vinegar.Using NaNO2-Al
(NO3)3The content for the general flavone that-NaOH methods measure said extracted obtains.Guava is total in the species and alcohol of 10 kinds of microorganisms
Flavones content is as shown in table 2.
Table 2
As shown in Table 2, the fermentation of sealwort brown sugar solution, obtained Siberian solomonseal rhizome polysaccharide content highest are carried out using fragrant yeast.It is comprehensive
Table 3 is closed, Aspergillus batatae (AS3324) wheat bran distiller's yeast is considered as and fragrant yeast carries out joint alcoholic fermentation.But due to two kinds of bacterium
Easily affected one another during kind fermentation, the inoculation ratio of the two is even more important, and by optimum experimental, it is found that fragrant yeast accounts for Aspergillus batatae
(AS3324) during wheat bran yeast 15~25%, ferment effect is best, the two growth can obtain normal growth, and Siberian solomonseal rhizome polysaccharide and
The content of guava general flavone is higher, and the content of Siberian solomonseal rhizome polysaccharide can reach more than 60mg/mL, and the content of general flavone can reach
To more than 15mg/100mL.
Influence of the embodiment 3pH values to Siberian solomonseal rhizome polysaccharide content and general flavone content
50 parts of sealwort, 50 parts of Fructus psidii guajavae immaturus are weighed, are crushed as coarse powder, mixing.Add 5 times of amount drinking water immersion 2h, decoct 3h,
40 DEG C of insulation 1h, add brown sugar, sugar addition to 23%, adjusts pH value to 1~8 after being cooled to 40 DEG C.
Suspension is cooled to 28-35 DEG C, accesses Aspergillus batatae (AS3324) wheat bran distiller's yeast of 10% (w/w), and is added
The fragrant yeast of wheat bran yeast 15% (w/w) is accounted for, is fermented after fully mixing, fermentation temperature is controlled at 15-20 DEG C, and mash is made
Middle cane sugar content obtains distiller's wort less than 1.5g/100ml fermentation ends.
1.01 saccharomycete are made in the Shanghai that 3% is added in distiller's wort, stir evenly, and temperature control is at 32~35 DEG C, when fermentation 60 is small,
Alcohol content drops to 0.4~0.6%, ferments to total acidity 5~7%, stops acetic fermentation and obtains vinegar wine with dregs, different pH condition
Under suspension fermentation after the obtained Siberian solomonseal rhizome polysaccharide of health-care vinegar and general flavone content respectively as depicted in figs. 1 and 2.By Fig. 1 and
Fig. 2 is understood, when the pH of suspension is adjusted to 3~5, the content highest of Siberian solomonseal rhizome polysaccharide and general flavone, Siberian solomonseal rhizome polysaccharide content 50~
82mg/mL, general flavone content is in 15~21mg/100mL.
In addition, inventor is attempted under pH3~5 and neutrallty condition using pan-fried using the sealwort of phase homogenous quantities and guava
The active ingredient in extraction sealwort and guava is boiled, decocts more than 5h, then detects the content of Siberian solomonseal rhizome polysaccharide and general flavone, is found
Siberian solomonseal rhizome polysaccharide content is 18~22mg/mL under the conditions of pH3~5, and general flavone content is 7~11mg/100mL；And under neutrallty condition
Siberian solomonseal rhizome polysaccharide content is 17.82mg/mL, general flavone content 7.1mg/100mL.
Embodiment 4
50 parts of sealwort, 50 parts of Fructus psidii guajavae immaturus are weighed, are crushed as coarse powder, mixing.Add 5 times of amount drinking water immersion 2h, decoct 3h,
40 DEG C of insulation 1h, add brown sugar, sugar addition to 23%, adjusts pH value to 4.0~4.2 after being cooled to 40 DEG C.
Suspension is cooled to 28-35 DEG C, accesses Aspergillus batatae (AS3324) wheat bran distiller's yeast of 10% (w/w), and is added
The fragrant yeast of wheat bran yeast 15% (w/w) is accounted for, is fermented after fully mixing, fermentation temperature is controlled at 15-20 DEG C, and mash is made
Middle cane sugar content obtains distiller's wort less than 1.5g/100ml fermentation ends.
1.01 saccharomycete are made in the Shanghai that 3% is added in distiller's wort, stir evenly, and temperature control is at 32~35 DEG C, when fermentation 60 is small,
Alcohol content drops to 0.4~0.6%, ferments to total acidity 5~7%, stops acetic fermentation and obtains vinegar wine with dregs.
Add 1% edible salt into the vinegar wine with dregs after fermentation, stir evenly, add 7% white bole and 0.15% it is poly-
Ethernamine, stirs evenly, and carries out after-ripening within closed static 10-15 days, the vinegar liquid of after-ripening is repeatedly filtered to clear, be made
Fermented vinegar, by fermented vinegar sealing and standing ageing more than 10 days；The acetic acid content of ageing is measured, adds water to convert to acetic acid content to 3-
5%, up to Siberian solomonseal rhizome health-care vinegar.The physical and chemical index of Siberian solomonseal rhizome health-care vinegar is as shown in table 3.
Table 3
Embodiment 5
50 parts of sealwort, 40 parts of Fructus psidii guajavae immaturus are weighed, are crushed as coarse powder, are mixed, adds 5 times of amount drinking water immersion 2h, decocts 3h,
40 DEG C of insulation 1h, add brown sugar, sugar addition to 23%, adjusts pH value to 4.0~4.2 after being cooled to 40 DEG C.Suspension is dropped
Temperature accesses Aspergillus batatae (AS3324) wheat bran distiller's yeast of 10% (w/w), and add and account for wheat bran yeast 20% (w/w) to 28-35 DEG C
Fragrant yeast, fully mix after ferment, fermentation temperature control at 15-20 DEG C, be made mash in cane sugar content be less than 1.5g/
100ml fermentation ends obtain distiller's wort.
1.01 saccharomycete are made in the Shanghai that 3% is added in distiller's wort, stir evenly, and temperature control is at 32~35 DEG C, when fermentation 65 is small,
Alcohol content drops to 0.4~0.6%, ferments to total acidity 5~7%, stops acetic fermentation and obtains vinegar wine with dregs.
1.5% edible salt is added into the vinegar wine with dregs after fermentation, stir evenly, add 8% white bole and 0.20%
Polyvinyl lactam, stirs evenly, and carries out after-ripening within closed static 10-15 days, and the vinegar liquid of after-ripening is repeatedly filtered to clear, system
Fermented vinegar is obtained, by fermented vinegar sealing and standing ageing more than 10 days；The acetic acid content of ageing is measured, adds water to convert to acetic acid content to 3-
5%, up to Siberian solomonseal rhizome health-care vinegar.The physical and chemical index of Siberian solomonseal rhizome health-care vinegar is as shown in table 4.
Table 4
Embodiment 6
60 parts of sealwort, 50 parts of Fructus psidii guajavae immaturus are weighed, are crushed as coarse powder, mixing.The 3 times of amount drinking water immersions of dosing material gross mass
2h, decocts 3h, 40 DEG C of insulation 1h, add brown sugar, sugar addition to 25%, adjusts pH value to 4.0~4.2 after being cooled to 40 DEG C.
Suspension is cooled to 28-35 DEG C, accesses Aspergillus batatae (AS3324) wheat bran distiller's yeast of 15% (w/w), and add and account for wheat bran ferment
The fragrant yeast of 25% (w/w) of mother, ferments after fully mixing, and fermentation temperature is controlled at 15-20 DEG C, and sucrose in mash is made and contains
Amount obtains distiller's wort less than 1.5g/100ml fermentation ends.
1.01 saccharomycete are made in the Shanghai that 3% is added in distiller's wort, stir evenly, and for temperature control at 32~35 DEG C, fermentation 60-80 is small
When, alcohol content drops to 0.5%, ferments to total acidity 5~7%, stops acetic fermentation and obtains vinegar wine with dregs.
Add 1% edible salt into the vinegar wine with dregs after fermentation, stir evenly, add 9% white bole and 0.15% it is poly-
Ethernamine, stirs evenly, and carries out after-ripening within closed static 10-15 days, the vinegar liquid of after-ripening is repeatedly filtered to clear, be made
Fermented vinegar, by fermented vinegar sealing and standing ageing more than 10 days；The acetic acid content of ageing is measured, adds water to convert to acetic acid content to 3-
5%, up to Siberian solomonseal rhizome health-care vinegar.The physical and chemical index of Siberian solomonseal rhizome health-care vinegar is as shown in table 5.
Table 5
Embodiment 7
60 parts of sealwort, 50 parts of Fructus psidii guajavae immaturus are weighed, are crushed as coarse powder, mixing.The 4 times of amount drinking water immersions of dosing material gross mass
2h, decocts 2h, brown sugar is added after being cooled to 40 DEG C, sugar addition to 25%, adjusts pH value to 4.0~4.2.Suspension is cooled down
To 28-35 DEG C, Aspergillus batatae (AS3324) wheat bran distiller's yeast of 20% (w/w) is accessed, and add and account for wheat bran yeast 20% (w/w)
Fragrant yeast, ferments after fully mixing, and fermentation temperature is controlled at 15-20 DEG C, and cane sugar content in mash is made and is less than 1.5g/
100ml fermentation ends obtain distiller's wort.1.01 saccharomycete are made in the Shanghai that 3% is added in distiller's wort, stir evenly, temperature control is 32~35
DEG C, when fermentation 60-80 is small, alcohol content drops to 0.4~0.6%, ferments to total acidity 5~7%, stops acetic fermentation and obtains
Vinegar wine with dregs.
2% edible salt is added into the vinegar wine with dregs after fermentation, is stirred evenly, adds 8% white bole and 0.2% poly- second
Acrylamide, stirs evenly, and carries out after-ripening within closed static 10-15 days, the vinegar liquid of after-ripening is repeatedly filtered to clear, hair is made
Ferment vinegar, by fermented vinegar sealing and standing ageing more than 10 days；The acetic acid content of ageing is measured, adds water to convert to acetic acid content to 3-5%,
Up to Siberian solomonseal rhizome health-care vinegar.The physical and chemical index of Siberian solomonseal rhizome health-care vinegar is as shown in table 6.
Table 6
Embodiment 8
60 parts of sealwort, 50 parts of Fructus psidii guajavae immaturus are weighed, are crushed as coarse powder, mixing.The 5 times of amount drinking water immersions of dosing material gross mass
2h, decocts 3h, 40 DEG C of insulation 1h, add brown sugar, sugar addition to 25%, adjusts pH value to 4.0~4.2 after being cooled to 40 DEG C.
Suspension is cooled to 28-35 DEG C, accesses Aspergillus batatae (AS3324) wheat bran distiller's yeast of 15% (w/w), and add and account for wheat bran ferment
The fragrant yeast of 25% (w/w) of mother, ferments after fully mixing, and fermentation temperature is controlled at 15-20 DEG C, and sucrose in mash is made and contains
Amount obtains distiller's wort less than 1.5g/100ml fermentation ends.
1.01 saccharomycete are made in the Shanghai that 3% is added in distiller's wort, stir evenly, and for temperature control at 32~35 DEG C, fermentation 60-80 is small
When, alcohol content drops to 0.6%, ferments to total acidity 5~7%, stops acetic fermentation and obtains vinegar wine with dregs.
Add 2% edible salt into the vinegar wine with dregs after fermentation, stir evenly, add 9% white bole and 0.25% it is poly-
Ethernamine, stirs evenly, and carries out after-ripening within closed static 10-15 days, the vinegar liquid of after-ripening is repeatedly filtered to clear, be made
Fermented vinegar, by fermented vinegar sealing and standing ageing more than 10 days；The acetic acid content of ageing is measured, adds water to convert to acetic acid content to 3-
5%, up to Siberian solomonseal rhizome health-care vinegar.The physical and chemical index of Siberian solomonseal rhizome health-care vinegar is as shown in table 7.
Table 7
Embodiment 9
50 parts of sealwort, 40 parts of Fructus psidii guajavae immaturus are weighed, are crushed as coarse powder, mixing.The 3 times of amount drinking water immersions of dosing material gross mass
2h, decocts 3h, 40 DEG C of insulation 1h, add brown sugar, sugar addition to 25%, adjusts pH value to 4.0~4.2 after being cooled to 40 DEG C.
Suspension is cooled to 28-35 DEG C, accesses Aspergillus batatae (AS3324) wheat bran distiller's yeast of 15% (w/w), and add and account for wheat bran ferment
The fragrant yeast of 25% (w/w) of mother, ferments after fully mixing, and fermentation temperature is controlled at 15-20 DEG C, and sucrose in mash is made and contains
Amount obtains distiller's wort less than 1.5g/100ml fermentation ends.
1.01 saccharomycete are made in the Shanghai that 3% is added in distiller's wort, stir evenly, and for temperature control at 32~35 DEG C, fermentation 60-80 is small
When, alcohol content drops to 0.4%, ferments to total acidity 5~7%, stops acetic fermentation and obtains vinegar wine with dregs.
Add 2% edible salt into the vinegar wine with dregs after fermentation, stir evenly, add 7% white bole and 0.15% it is poly-
Ethernamine, stirs evenly, and carries out after-ripening within closed static 10-15 days, the vinegar liquid of after-ripening is repeatedly filtered to clear, be made
Fermented vinegar, by fermented vinegar sealing and standing ageing more than 10 days；The acetic acid content of ageing is measured, adds water to convert to acetic acid content to 3-
5%, up to Siberian solomonseal rhizome health-care vinegar.The physical and chemical index of Siberian solomonseal rhizome health-care vinegar is as shown in table 8.
Table 8
The present invention shows Siberian solomonseal rhizome health-care vinegar drug regimen to treating hyperglycaemia through so-and-so hospital's pharmacological evaluation and clinical verification
There is obvious clinical therapeutic efficacy：
First, the animal health effect of Siberian solomonseal rhizome health-care vinegar
Choose experimental animal：C57BL/6J mouse, male ablactation (21 days).Modeling medicine：Streptozotocin (STZ) is high
Fatty feed, citric acid.
Mouse is randomly divided into tetra- groups of A, B, C, D, and A groups are normal diet control group (normal diet adding citric acids), and A groups are general
Logical feed experimental group (normal diet adds STZ), C groups are that high fat diet control group (high lipid food adding citric acid) D groups are higher fatty acid
Experimental group (high fat diet adds STZ), the fasting of the 3rd weekend 12h, B, D group intraperitoneal injection STZ, 100mg/KG, causes diabetes mould
Type.Control group 1 extracts sealwort and guava using decocting method, and active ingredient contains 1 gram of crude drug (sealwort for every milliliter in decoction liquor
With guava 1：1) common fermentation vinegar, is then added, it is identical with control group 1 to acidity 5~7%.Siberian solomonseal rhizome health-care vinegar is to diabetes
The influence of mouse blood sugar, is shown in Table 9.
Influence (X ± S) of the 9 Siberian solomonseal rhizome health-care vinegar of table to blood glucose in diabetic mice
The blood glucose for feeding Siberian solomonseal rhizome health-care vinegar group mouse is significantly lower than control group P<0.001.
Influence of the Siberian solomonseal rhizome health-care vinegar to diabetic mice food-intake, amount of drinking water and urine volume, is shown in Table 10.
Table 10
Note：Every group 15
Table 10 shows that Siberian solomonseal rhizome health-care vinegar has clear improvement diabetic experimental mouse symptom more than three, close to intact animal into
Water, food-intake, urine volume, therefore health-care vinegar is also suitable for diabetic.Vinegar has the function of reducing postprandial hyperglycemia, it is believed that in vinegar
Acetic acid (acetic acid) gastric emptying can be postponed, delay carbohydrate absorption speed, increase satiety, reduce glycemic index.
2nd, the hyperglycemic patients caused by the present invention chooses deficiency of both qi and yin carry out clinical research.
Syndrome of deficiency of both qi and yin patient is mainly shown as：Polydipsia is drunk more, and rapid digestion of food and polyorexia, body is become thin, fatigue and weak, and shortness of breath is lazy
Speech, lustreless complexion, the red tongue of tongue is few, thready and rapid pulse without strength.Preferably control nourishing generate fluid, enriching yin and nourishing kidney.
Hyperglycemic patients 65 are have selected, meet clinical criteria, no gestation, lactation, no liver, kidney, angiocarpy, brain
The diseases such as the primary diseases such as blood vessel, hemopoietic system, mental disease；It can adhere to completing treatment, and further consultation on time, timely feedback letter
Breath.Patient age 35-55 Sui, course of disease 1-3, is randomly divided into, treatment group 50, control group 18.Control group takes drop of quenching one's thirst
Siberian solomonseal rhizome health-care vinegar 30ml takes in carbohydrate gum capsule (3 times a day, 4 tablets each time, Tonghua Great Wall pharmaceutcal corporation, Ltd), treatment group, and daily 3
It is secondary, take before the meal, during treatment, other hypoglycemic medicines disable.
Evaluate the detection of sugared index：Before taking, take latter 1 month and take 3 months afterwards, detection test personnel are before the meal
Blood glucose value in (empty stomach) and postprandial 2h blood.
Curative effect：Siberian solomonseal rhizome health-care vinegar curative effect is substantially better than control group, its treatment rate substantially compares apparently higher than control group, recurrence rate
Control group is low.Two groups relatively have conspicuousness statistical significance.Treatment group occurs without the uncomfortable reaction such as allergy, hypoglycemia, wherein one
Row prostatitis patient take tell after this medicine frequent micturition, odynuria symptom be improved significantly.Take after Siberian solomonseal rhizome health-care vinegar 1 month, meal
Before the blood glucose value of (empty stomach) and postprandial 2h reduce 3.0%-20.5% and 15.6%-27.5% respectively；Take 3 months, before the meal
The blood glucose value of (empty stomach) and postprandial 2h reduce 11.0%-28.6% and 27.8%-41.3% (table 5) respectively.Siberian solomonseal rhizome health-care vinegar
Hyperglycaemia results contrast is treated, is shown in Table 11.
Table 11
**P<0.01*P>0.01
As shown in table 11, after medication 1 month before take compared to there was no significant difference, after medication 2 months with take medicine before phase
Than there is significant difference.Experiment confirms that Siberian solomonseal rhizome health-care vinegar has II type patients with type Ⅰ DM diabetic the effect of notable, without obvious
Liver kidney toxicity, side effect, has good security.Note：Ketoacidosis person disables.
Siberian solomonseal rhizome health-care vinegar pharmaceutical composition prepared by the present invention has a better effect treatment hyperglycaemia, for current high blood
The rejuvenation of sugared incidence, and the present situation that number of the infected increasingly doubles, the present invention have very high Development volue and clinical practice
Prospect.
To the technology of fields, the change and variation of other forms can also be made on the basis of the above description.It is real
Mode is applied as exhaustion, it is all belong to change that technical scheme amplified or change appoint in protection scope of the present invention it
It is interior.
Claims (9)
1. a kind of Siberian solomonseal rhizome health-care vinegar, it is characterised in that the Siberian solomonseal rhizome health-care vinegar is mainly made of the fermenting raw materials of following parts by weight：
40~85 parts of sealwort, 20~68 parts of Fructus psidii guajavae immaturus, 1~25 part of brown sugar.
2. Siberian solomonseal rhizome health-care vinegar according to claim 1, it is characterised in that 50~70 parts of the sealwort, Fructus psidii guajavae immaturus 30~
50 parts, 2~18 parts of brown sugar.
3. Siberian solomonseal rhizome health-care vinegar as claimed in claim 1, it is characterised in that the physical and chemical index of the health-care vinegar is as follows：With acetic acid
Meter, total acid are not less than 3g/100mL；With glucose meter, content of reducing sugar is less than 1g/100mL；Total reducing sugar is not less than 8g/100mL；Wine
Precision is less than 0.2 (v/v), and general flavone content is more than 15mg/100mL, and Siberian solomonseal rhizome polysaccharide content is more than 60mg/mL.
A kind of 4. preparation method of Siberian solomonseal rhizome health-care vinegar as described in claims 1 to 3 is any, it is characterised in that the preparation side
Method operation is as follows：Decocted after weighing sealwort and guava dry plate immersion by weight, be made into suspension with brown sugar after cooling, be suspended
Liquid through Aspergillus batatae (AS3324) wheat bran distiller's yeast and fragrant yeast carry out alcoholic fermentation, again through acetic acid saccharomycete carry out acetic fermentation,
Filtering, it is post-treated to obtain Siberian solomonseal rhizome health-care vinegar.
5. the preparation method of Siberian solomonseal rhizome health-care vinegar as claimed in claim 4, it is characterised in that the suspension configuration process is such as
Under：Crushed respectively after the section of the dry root of sealwort and Fructus psidii guajavae immaturus are cleaned, add water reach every milliliter containing 0.1~1 gram of sealwort and
Pan Shiliu medicinal materials, after medicinal material immersion, heating stirring decocts 30-150min, and brown sugar, adjustment sugar are added after being cooled to 30~50 DEG C
Degree adjusts pH value to 3-5, obtains suspension to 20-25%.
6. the preparation method of Siberian solomonseal rhizome health-care vinegar as claimed in claim 4, it is characterised in that the alcoholic fermentation process is as follows：
Suspension is cooled to 28-35 DEG C, accesses Aspergillus batatae (AS3324) wheat bran distiller's yeast of 5-15% (w/w), and add and account for wheat bran
The fragrant yeast of yeast 15~25% (w/w), ferments after fully mixing, and fermentation temperature is controlled at 15-20 DEG C, is made in mash
Cane sugar content obtains distiller's wort less than 1.5g/100ml fermentation ends.
7. the preparation method of Siberian solomonseal rhizome health-care vinegar as claimed in claim 4, it is characterised in that the acetic fermentation process is as follows：
1.01 saccharomycete are made in the Shanghai that 2-5% is added in distiller's wort, stir evenly, and temperature control is at 32~35 DEG C, when fermentation 60-80 is small, wine
Smart content drops to 0.4~0.6%, ferments to total acidity 5~7%, stops acetic fermentation and obtains vinegar wine with dregs.
8. the preparation method of Siberian solomonseal rhizome health-care vinegar as claimed in claim 4, it is characterised in that the last handling process is as follows：To
1-2% edible salts are added in vinegar wine with dregs after fermentation, stirs evenly, adds the white bole of 7-9% and the poly- second of 0.15-0.25%
Acrylamide, stirs evenly, and carries out after-ripening within closed static 10-15 days, the vinegar liquid of after-ripening is repeatedly filtered to clear, hair is made
Ferment vinegar, by fermented vinegar sealing and standing ageing more than 10 days；The acetic acid content of ageing is measured, adds water to convert to acetic acid content to 3-5%,
Up to Siberian solomonseal rhizome health-care vinegar.
A kind of 9. application of Siberian solomonseal rhizome health-care vinegar in prevention, treatment hyperglycemia medicine is prepared.
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