CN108022822B - The in-out apparatus of MALDI TOF MS instrument sample target - Google Patents
The in-out apparatus of MALDI TOF MS instrument sample target Download PDFInfo
- Publication number
- CN108022822B CN108022822B CN201711277024.1A CN201711277024A CN108022822B CN 108022822 B CN108022822 B CN 108022822B CN 201711277024 A CN201711277024 A CN 201711277024A CN 108022822 B CN108022822 B CN 108022822B
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- sample target
- connecting rod
- dimensional surface
- jacking mechanism
- main cavity
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
The in-out apparatus of MALDI TOF MS instrument sample target, is related to time of-flight mass spectrometer.Equipped with main cavity, main cavity cover board and molecular pump, main chamber body, main cavity cover board and molecular pump form vacuum system, two-dimensional surface mobile mechanism and connecting rod jacking mechanism are equipped in the vacuum system, the connecting rod jacking mechanism is located in two-dimensional surface mobile mechanism；The mobile drive connecting rod jacking mechanism realization of the two-dimensional surface mobile mechanism put with taking sample target and vacuum sealing, and realize and will be moved to the position of test mounted in the sample target of sample target slot；Accurate lead screw rotation is driven by shaft coupling by vacuum stepper motor, so that Y-direction movable block be driven to move back and forth in Y-direction, controls sample target slot shift position with the encoder of position-sensing switch and record position；Movement in same X-direction also uses similar mechanism.
Description
Technical field
The present invention relates to time of-flight mass spectrometers, more particularly, to MALDI TOF MS instrument sample
The in-out apparatus of target.
Background technique
The ionization process of MALDI TOF MS sample and the Mass Spectrometer Method process of sample are all
It is carried out in the environment of high vacuum.Sample under normal temperature and pressure environment is transferred to vacuum system and realizes more throughput samples
Test is required to a reliable transmission mechanism and accurate positioning mobile mechanism to guarantee.It is also wanted in the transmittance process of sample
Guarantee that vacuum system cannot be destroyed, is even more important so the disengaging structure of sample target seems in the quasi-instrument.
For the transmitting and test for realizing MALDI TOF MS instrument sample, have many types at present
Sample target disengaging structure, it is most of all to be realized using the target slot equipped with sample target through the transmitting of multistage link mechanism.This is more
Connecting rod transmission mechanism, structure is complicated, and link mechanism all uses riveting method, assembly difficulty, to personnel substantially the reason of because of space
It is required that it is high, and the failures such as quality is inconsistent, is easy to appear bite, riveting falls off；It involves great expense；There are also the target slots because filling sample target
It is that target slot may occur in the transport of instrument, handling process and fall off in the state not being fixedly connected in the inside of instrument,
To cause failure.
Summary of the invention
The movement of the disengaging and test position for being designed to provide achievable sample target of the invention, structure is simple, can
By the in-out apparatus with durable MALDI TOF MS instrument sample target.
The present invention is equipped with main cavity, main cavity cover board and molecular pump, main chamber body, main cavity cover board and molecular pump composition
Vacuum system is equipped with two-dimensional surface mobile mechanism and connecting rod jacking mechanism, the connecting rod jacking mechanism in the vacuum system
It is located in two-dimensional surface mobile mechanism；
The mobile drive connecting rod jacking mechanism realization of the two-dimensional surface mobile mechanism is put close with taking sample target and vacuum
Envelope, and realization will be moved to the position of test mounted in the sample target of sample target slot；
By vacuum stepper motor by shaft coupling drive accurate lead screw rotation, thus drive Y-direction movable block in Y-direction back and forth
Movement controls sample target slot shift position with the encoder of position-sensing switch and record position；Movement in same X-direction also uses
Similar mechanism.
When the position that two-dimensional surface mobile mechanism moves to left Y-direction movable block, drive connecting rod jacking mechanism to the left side
Movement, when the bearing on connecting rod jacking mechanism encounters the inner wall of main cavity, Y-direction movable block continues to move downward, in connecting rod
It drives lower bearing to move upwards along main cavity inner wall, so that sample target slot be driven to move upwards, would be pressed against main cavity when moving to
When cover board, sealing is realized by compression O circle, sample target is sent to the position put and taken to realize, at this moment connecting rod just at
Plumbness, when taking or when setting-out product target, the pressure of atmosphere directly can be transmitted to linear guide by connecting rod, to protect screw rod
Nut；When needing test sample target, vacuum stepper motor reversely rotates to drive Y-direction mobile in two-dimensional surface mobile mechanism
Block moves right, and connecting rod jacking mechanism above mobile mechanism is driven also to move to the right, since connecting rod jacking mechanism is equipped with return
Spring, under the pulling force effect of return spring, so that sample target slot is driven to fall back on adjustment positioning column, it is fixed by adjusting adjustment
The height of position column, to realize size of the sample range from extraction pole.
The present invention includes movement below: transporting the orientable planar movement mechanism of sample target；Increase sample target
With the connecting rod top target drone structure for compressing O circle.
The advantage of the invention is that increasing sample target during the disengaging of sample target and compressing the mechanism of O circle using simple
Link mechanism；Sample target slot is connect in entirely disengaging instrument and detection process with mobile mechanism, will not transport sample cell
Or phenomena such as being fallen in instrument transport handling process；Structure is reliable simultaneously, and assembly is simple.
Detailed description of the invention
Fig. 1 is the floor map of the embodiment of the present invention；
Fig. 2 is the schematic three dimensional views of the embodiment of the present invention；
Fig. 3 is the connecting rod jacking mechanism initial position schematic diagram of the embodiment of the present invention；
Fig. 4 is the connecting rod jacking mechanism elevation process schematic diagram of the embodiment of the present invention；
Fig. 5 is that the connecting rod jacking mechanism of the embodiment of the present invention is raised to top schematic diagram.
Specific embodiment
The following further describes the present invention with reference to the drawings.
As illustrated in fig. 1 and 2, the environment for the high vacuum that the present invention is made of main cavity 1, main cavity cover board 4 and molecular pump 5
It is interior, the two-dimensional surface mobile mechanism 3 in the vacuum system, and the connecting rod jacking mechanism 2 in two-dimensional surface mobile mechanism.
Molecular pump 5 is connect with main cavity 1 using the interior hexagonal double-ended bolt of c-type clamp and M10；Main cavity cover board 4 is using hexagonal spiral shell in 4 M6
Column is fixedly connected with main cavity 1；Two-dimensional surface mobile mechanism 3 is fixedly connected using hexagonal double-ended bolt in 6 M4 with main cavity 1；Even
Bar jacking mechanism 2 is fixedly connected using hexagonal double-ended bolt in 4 M5 with two-dimensional surface mobile mechanism 3.
When work, is connected by high vacuum stepper motor 19 by shaft coupling 16 and accurate lead screw 12 is driven to rotate, thus band
Dynamic Y-direction movable block 11 moves back and forth in the Y direction, which is controlled using the encoder 17 of position-sensing switch 14 and record position
22 shift position of sample target slot；Movement in same X-direction also uses similar mechanism；The movement of two-dimensional surface mobile mechanism 3
Drive the connecting rod jacking mechanism 2 on top realize put with taking sample target and vacuum sealing in terms of required for action request, and
It realizes and is moved to each need position to be tested with the sample target mounted in sample target slot 22.High vacuum stepper motor 19 uses 4
Hexagonal double-ended bolt and platform base 15 in 4 M4 are fixed together with Y-motor fixed plate 18 for hexagonal double-ended bolt in a M3；Position-sensing switch 14
Fixed using the pan head screw and locating piece 13 of two M2.5, locating piece 13 is using hexagonal double-ended bolt and platform base 15 in two M3
It is fixedly connected；Encoder 17 is fixedly connected using hexagonal double-ended bolt in two M2.5 with Y-motor fixed plate 18.
The work of connecting rod jacking mechanism 2 of the invention as seen in figures 3-5, when two-dimensional surface mobile mechanism 3 is by Y-direction movable block
11 positions to move to left drive connecting rod jacking mechanism 2 above mobile mechanism also to move to the left side, when on jacking mechanism 2
When bearing 21 encounters the inner wall of main cavity 1, Y-direction movable block 11 continues to move downward, connecting rod 26 drive lower bearing 21 along master
1 inner wall of cavity moves upwards, so that sample target slot 22 be driven to move upwards；When move to be pressed onto main cavity cover board 4 fastly when, pass through
It compresses O circle and realizes sealing, sample target is sent to the positions of taking and placing to realize, at this moment connecting rod 26 is just at plumbness, this
When sample taking and placing sample target, the pressure of atmosphere directly can be transmitted to X linear guide group 8 and Y linear guide group 20 by connecting rod 26, from
And the feed screw nut protected.When needing test sample target, high vacuum stepper motor 19 reversely revolves in two-dimensional surface mobile mechanism 3
Turn to move right with Y-direction movable block 11, drives connecting rod jacking mechanism 2 above mobile mechanism also to move to the right, due to even
Bar jacking mechanism 2 is equipped with return spring 24, under the pulling force effect of return spring 24, so that sample target slot be driven to fall back to adjustment
On positioning column 25, by adjusting the height of adjustment positioning column 25, to realize size of the sample range from extraction pole.Wherein Y-direction
Movable block 11 is fixedly connected using hexagonal double-ended bolt in 16 M3 with the sliding block of X linear guide group 8, and the guide rail of X linear guide group 8 is adopted
It is fixedly connected with hexagonal double-ended bolt in M3 with Y-direction movable block 11；Y-direction movable block 11 is connect using Y linear guide with platform base 15
Group 20.Sample target slot 22 is fixedly connected using 4 PEEK screws with isolation board 23；Isolation board 23 uses 4 PEEK screws and company
The bar seat of honour 28 connects；Bearing 21 is connect through shaft 27 with the connecting rod seat of honour 28；Two end caps of return spring 24, should in two shafts 27
Shaft be through respectively the connecting rod seat of honour 28, connecting rod base 29 hole in；Adjust screw thread and connecting rod base that positioning column 25 passes through itself
29 link together；Connecting rod base 29 is fixed together with X movable plate 6 using hexagonal double-ended bolt in 3 M5.
Claims (2)
1. the in-out apparatus of MALDI TOF MS instrument sample target, it is characterised in that be equipped with main cavity, master
Cavity cover board and molecular pump, main chamber body, main cavity cover board and molecular pump form vacuum system, are equipped in the vacuum system
Two-dimensional surface mobile mechanism and connecting rod jacking mechanism, the connecting rod jacking mechanism are located in two-dimensional surface mobile mechanism；
The two-dimensional surface mobile mechanism mobile drive connecting rod jacking mechanism realization put with taking sample target and vacuum sealing, and
The position of test will be moved to mounted in the sample target of sample target slot by realizing；
Vacuum stepper motor drives accurate lead screw rotation by shaft coupling, so that Y-direction movable block be driven to move back and forth in Y-direction, uses
The encoder of position-sensing switch and record position controls sample target slot shift position；
The position that the two-dimensional surface mobile mechanism moves to left Y-direction movable block drives connecting rod jacking mechanism to transport to the left side
Dynamic, when the bearing on connecting rod jacking mechanism encounters the inner wall of main cavity, Y-direction movable block continues to move downward, in the band of connecting rod
Dynamic lower bearing is moved upwards along main cavity inner wall, so that sample target slot be driven to move upwards；It would be pressed against main cavity lid when moving to
When plate, sealing to be realized by compression O circle, sample target is sent to the position put and taken to realize, connecting rod is in plumbness, when
It takes or when setting-out product target, the pressure of atmosphere directly passes through connecting rod and is transmitted to linear guide, to protect feed screw nut.
2. the in-out apparatus of MALDI TOF MS instrument sample target as described in claim 1, feature exist
When test sample target, vacuum stepper motor reversely rotates that Y-direction movable block is driven to transport to the right in two-dimensional surface mobile mechanism
It is dynamic, drive connecting rod jacking mechanism above mobile mechanism also to move to the right, connecting rod jacking mechanism is equipped with return spring, in return bullet
Under the pulling force effect of spring, so that sample target slot is driven to fall back on adjustment positioning column, by adjusting the height of adjustment positioning column, from
And realize size of the sample range from extraction pole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711277024.1A CN108022822B (en) | 2017-12-06 | 2017-12-06 | The in-out apparatus of MALDI TOF MS instrument sample target |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711277024.1A CN108022822B (en) | 2017-12-06 | 2017-12-06 | The in-out apparatus of MALDI TOF MS instrument sample target |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108022822A CN108022822A (en) | 2018-05-11 |
| CN108022822B true CN108022822B (en) | 2019-08-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711277024.1A Active CN108022822B (en) | 2017-12-06 | 2017-12-06 | The in-out apparatus of MALDI TOF MS instrument sample target |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109270285A (en) * | 2018-11-19 | 2019-01-25 | 厦门元谱生物科技有限公司 | A kind of vacuum sampling device |
| CN109712863A (en) * | 2019-02-26 | 2019-05-03 | 安图实验仪器(郑州)有限公司 | Vacuum interactive system suitable for laser desorption ionization time of flight mass spectrometry instrument |
| CN109900780A (en) * | 2019-04-02 | 2019-06-18 | 厦门历思科技服务有限公司 | The online pretreating device of hair sample sample introduction |
| CN114388336B (en) * | 2022-01-18 | 2023-09-01 | 生物岛实验室 | Portable small-sized time-of-flight mass spectrometer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4918662B2 (en) * | 2007-06-27 | 2012-04-18 | 国立大学法人 東京大学 | Sample holder and mass spectrometry method for MALDI mass spectrometry |
| CN102306603B (en) * | 2011-08-19 | 2013-03-06 | 北京大学 | Mass spectrum multichannel rotary electrospray ion source |
| WO2017035229A1 (en) * | 2015-08-24 | 2017-03-02 | Zeteo Tech, Llc | Coating of aerosol particles using an acoustic coater |
| CN205246600U (en) * | 2015-12-11 | 2016-05-18 | 安图实验仪器(郑州)有限公司 | Analytic ion source business turn over appearance device of matrix auxiliary laser |
| CN105891318A (en) * | 2016-06-12 | 2016-08-24 | 江苏天瑞仪器股份有限公司 | Matrix-assisted laser desorption ion source sampling device |
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| CN108022822A (en) | 2018-05-11 |
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Effective date of registration: 20200617 Address after: No.5, Taikang Road, building 38, Jianqiao Industrial Park, Dadukou District, Chongqing Patentee after: Chongqing topu Bioengineering Co., Ltd Address before: 361028 01-03 unit, tenth floor, building 1, Xiamen bio Pharmaceutical Industrial Park, 2050 West Weng Road West, Haicang District, Xiamen, Fujian Patentee before: FUJIAN BRANCH OF JIANGSU SKYRAY INSTRUMENT Co.,Ltd. |
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Effective date of registration: 20210728 Address after: 6 / F, no.1-400000, industrial park, Taikang District, Chongqing Patentee after: CHONGQING ZHONGYUAN HUIJI BIOTECHNOLOGY Co.,Ltd. Address before: No.5, Taikang Road, No.38 standard workshop, Zone C, Jianqiao Industrial Park, Dadukou District, Chongqing 400084 Patentee before: Chongqing topu Bioengineering Co., Ltd |
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Address after: Floor 1-4, building 30, No. 6, Taikang Road, Zone C, Jianqiao Industrial Park, Dadukou District, Chongqing 404100 Patentee after: Zhongyuan Huiji Biotechnology Co.,Ltd. Address before: 6 / F, no.1-400000, industrial park, Taikang District, Chongqing Patentee before: CHONGQING ZHONGYUAN HUIJI BIOTECHNOLOGY Co.,Ltd. |