CN107998243A - A kind of preparation method of two-component treatment tinea pedis medicine - Google Patents
A kind of preparation method of two-component treatment tinea pedis medicine Download PDFInfo
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- CN107998243A CN107998243A CN201711303479.6A CN201711303479A CN107998243A CN 107998243 A CN107998243 A CN 107998243A CN 201711303479 A CN201711303479 A CN 201711303479A CN 107998243 A CN107998243 A CN 107998243A
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- tinea pedis
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- medicine
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Abstract
The present invention is field of pharmaceutical technology, is related to a kind of preparation method of two-component treatment tinea pedis medicine.The present invention passes through Orally taken and externally, it is common to cure tinea pedis, prepare component A, the vitamin B complex of extraction belongs to water soluble vitamin, has and adjusts metabolism, is beneficial to promote cytothesis, maintain the health of foot's skin, prevent tinea pedis from regenerating, promote the function of immune system and nervous system, have in Chinese herbs decoction clearing heat and detoxicating, expelling wind and removing dampness, tonify Qi of the kidney, clearing and activating the channels and collaterals, promotes vola blood circulation, improve body immune defence power, so as to promote tinea pedis to heal, body immune mechanism is adjusted, controls the recurrence of tinea pedis and few hair.Boric acid has the mycostatic effect of suppression, salicylic acid can suppress fungi, softening epidermis, exfoliating, methenamine hidroschesis, convergence, zinc oxide is antipruritic, convergence, phenol sterilization has disinfection, metronidazole anti anaerobic bacteria infection, nitrofurazone plays the role of anti-inflammatory, easy to apply to form a film in skin surface, play a role, promote tinea pedis healing.
Description
Technical field
The present invention is field of pharmaceutical technology, is related to a kind of preparation method of two-component treatment tinea pedis medicine.
Background technology
Tinea pedis, that is, tinea pedis, is a kind of tinea class skin disease common as caused by fungal infection, is typically due to the small sweat of body
Glandular secretion is vigorous, and sweat gland secretion produces dirty smelly in the case where bacterium, mould are decomposed.Perspiration promotes bacterium easily to breed, therefore tinea pedis
Often occur together with ephidrosis.Ancient books is referred to as smelly river snail, river snail blister, is commonly called as the ringworm of the foot, tinea pedis, athlete's foot, sportsman's foot etc..In
It is referred to as flaccidity of lower limbs to cure tinea pedis；《Essential Recipes for Emergent Use Worth A Thousand Gold》Roll up 22《Pathogenic wind-toxic beriberi side》：" so this disease hair, it is first to obtain first from foot, because being
Shin swells, when people number be tinea pedis；Deep Shi Yun：Foot weak person, i.e. its justice ".It is estimated that the people of 70-80% has tinea pedis in adult；Tinea pedis
It is as caused by dermatophyte (fungi)；Fungi likes the moist environment warmed, when skin is always held at the shape of humidity
Condition, epidermis especially sole are easiest to multiply fungi, when a large amount of numerous plants of fungi and invade cortex, just induce tinea pedis；Dermatophyte
Usually through the publilc baths of pollution, the floor bath towel of edge of pool, public slipper, foot basin and infect；Common infection position is toe
Between, Symptoms are local itch, skin blistering, peel off or be cracked, and skin injury also results in exposed subcutaneous tissue and swells
Swollen and infection；Infection is also possible to expand to the other positions of whole body, such as oxter, groin.
Medically usually by three types of tinea pedis point：Erosive type, vesicle, keratinization type tinea pedis；1st, erosive type：Be apt to occur in the 3rd with
Between 4th and the 5th toe；Moist between toe, phlysis of dipping turning white or rise dries up after furfur, peels off scurf as moistening, flush
Rotten to the corn face have and very itch, easy scabies secondary infection；2nd, vesicle：Foot edge portion is apt to occur in from the beginning of for the full phlysis of wall thickness, what is had can
Bleb is fused into, the transparent surrounding of blister liquid is without blush；Feel and very itch, often cause erysipelas angioleucitis after scratching because of scabies secondary infection
Deng；3rd, keratinization type：It is apt to occur in heel and is mainly shown as that skin is thick thick and dries, angling furfur, itching is easily chapped；This type without
Blister and suppuration, the course of disease are not cured slowly for many years；The harm of tinea pedis can not be ignored, and when morbidity not only influences daily life, but also influence
It is humanoid as, and it is same infection arrive other positions of body, secondary infection can be caused when serious, working and learning are also produced sternly
The influence of weight.
The method for being traditionally used for treatment tinea pedis is by the way that medicine directly is applied to affected part outside, medicine is passed through Cutaneous permeation
Treated into the tissue of human body.In the market common are various for treating the anti-dermatophytes such as tinea pedis, jock itch, ringworm of the body
The medicine of infection, such as Jiaoqiling for beriberi, JIAOXIAN YICIJING.Also be useful for treatment tinea pedis footwear, insole, socks etc., these methods due to
Its antimicrobial component deficiency, can not kill the infection of skin corium germ there are the defects of course for the treatment of length, weak curative effect, illness high recurrence rate, face
Bed effect is undesirable.The persistence of effect is poor, and many medicines have great side effect, it is impossible to tackle the problem at its root,
Most of tinea pedis patient treatments repeatedly cannot all fully recover, and will always recur after a while；And commercially available beriberi medicament is mostly
The irritation liquid of skin ambustion, patient when in use not only foot's erosion tract pain unbearably, but also medicine air-dry after can make
Lack moisture and very uncomfortable into dry skin, so many people can select to stop the way itched and be just discontinued, such one side
Treatment is not thorough and can not eradicate, and on the other hand smears liquid medicine position and very does unbearably.
Therefore, we are necessary to reformulate a kind of safety and efficient treatment tinea pedis medicine, are solved nowadays with this
There are the problem of.
The content of the invention
The technical problems to be solved by the invention：It is poor for the persistence of the effect of drugs of current treatment tinea pedis, after treatment
Tinea pedis easily recurs, medicine can be caused after air-drying dry skin lack moisture and it is very uncomfortable the problem of, there is provided a kind of double groups
The preparation method of part treatment tinea pedis medicine.
In order to solve the above technical problems, the present invention is using technical solution as described below：
A kind of preparation method of two-component treatment tinea pedis medicine, including A parts, B parts, preparation method A parts described includes following step
Suddenly：
（1）According to the mass fraction, 10 ~ 15 parts of Chinese yam, 8 ~ 9 parts of radix glycyrrhizae, 20 ~ 30 parts of kuh-seng, 12 ~ 15 parts of Cortex Phellodendri, the root of Chinese clematis 7 ~ 9 are taken
Part, 7 ~ 9 parts of alumen, 12 ~ 18 parts of luffa, adds 3000 parts of 1 ~ 2h of immersion of distilled water, obtains soaked medicinal material, will be soaked
Put into interlayer stainless steel medicinal cupping, lead to steam, be warming up to 90 ~ 100 DEG C, decoct, admixing medical solutions will have been decocted and be cooled to room temperature, will
4 ~ 5 layers of filtered through gauze of admixing medical solutions have been decocted after cooling, filtrate has been taken, filtrate is placed in 3 ~ 5h in 80 ~ 85 DEG C of water bath with thermostatic control,
Obtain Chinese herbs decoction；
（2）Take wheat bran to add in the hydrochloric acid solution that mass fraction is 0.2mol/L, obtain wheat bran mixed liquor, wheat bran mixed liquor is placed in
In ultrasonic cell disruptor, ultrasound, obtain it is ultrasonic after mixed solution, mixed solution after ultrasound is centrifuged, supernatant concentration is taken, obtains
Vitamin B1 extracting solution；
（3）Above-mentioned Chinese herbs decoction is mixed with vitamin B1 extracting solution, is stirred evenly, up to A parts；
Preparation method B parts described includes the following steps：
A. polyether Glycols PPG1000 and PPG200 are uniformly mixed, dehydration, obtains dehydrating mixt, by dehydrating mixt
Cooling, isophorone diisocyanate is added to after cooling down in dehydrating mixt, reaction, obtains reactant, added into reactant
Stannous octoate, carries out prepolymerization reaction, obtains prepolymerization reaction product, and acetone dilution is added into prepolymerization reaction product, pre- after must diluting
Polybutadiene reaction product, adds chain extender 1,4-butanediol and dimethylolpropionic acid, reaction, obtains to prepolymerization reaction product after dilution successively
Chain extending reaction thing, ethanol solution is added into chain extending reaction thing, and vacuum distillation, must remove acetone chain extending reaction thing, expand to acetone is removed
Absolute ethyl alcohol is added in chain reaction thing, obtains alcohol-soluble polyurethane solution；
B. count in parts by weight, take 100 ~ 150 parts of salicylic acid, 30 ~ 40 parts of benzoic acid, 10 ~ 13 parts of boric acid, methenamine 20 ~ 30
Part, 15 ~ 20 parts of zinc oxide, 20 ~ 25 parts of phenol, 10 ~ 12 parts of metronidazole, 10 ~ 15 parts of nitrofurazone, 25 ~ 30 parts of triethanolamine, alcohol
50 ~ 70 parts of soluble polyurethane solution, 40 ~ 50 parts of water, stirs evenly, and obtains B parts.
The step（1）The condition that middle steam decocts to be warming up to 90 ~ 100 DEG C, keep 0.5 kilogram of air pressure decoct 30 ~
40min。
The step（2）The mass ratio for the hydrochloric acid solution that middle wheat bran is 0.2mol/L with mass fraction is 1：8；Ultrasound condition
For 10 ~ 15min of ultrasound, protection temperature is 50 ~ 60 DEG C.
The step（3）The mass ratio of Chinese herbs decoction and vitamin B1 extracting solution is 5：3.
The mass ratio of polyether Glycols PPG1000 and PPG200 are 1 in the step a：2；Dehydration conditions are：105 ~
110 DEG C, 1 ~ 2h of dehydration under -0.95MPa vacuum conditions；Isophorone diisocyanate and the matter of dehydrating mixt after cooling
Amount is than being 2：3；The mass ratio of reactant and stannous octoate is 5：2；The mass ratio of prepolymerization reaction product and acetone is 6：1；Dilution
The mass ratio of prepolymerization reaction product, 1,4- butanediols and dimethylolpropionic acid is 5 afterwards：3：2；Chain extending reaction thing and ethanol solution
Mass ratio is 3：5；It is 5 to remove the mass ratio of acetone chain extending reaction thing and absolute ethyl alcohol：3.
The application method of two-component treatment tinea pedis medicine is：A parts：Oral, 2 times/d, each 150mL, warmly takes, controls
Treat 3 ~ 4 weeks；B parts：External application, spreads at tinea pedis, and 2 ~ 3 times daily.
Compared with other methods, advantageous effects are the present invention：
（1）The present invention cures tinea pedis, prepares component A, the vitamin B complex of extraction belongs to water soluble vitamin jointly by Orally taken and externally
Raw element, has and adjusts metabolism, is beneficial to promote cytothesis, maintains the health of foot's skin, prevent tinea pedis from regenerating, promotes
The function of immune system and nervous system, has in Chinese herbs decoction clearing heat and detoxicating, and expelling wind and removing dampness, tonifies Qi of the kidney, clearing and activating the channels and collaterals, promotees
Into vola blood circulation, body immune defence power is improved, so as to promote tinea pedis to heal, body immune mechanism is adjusted, controls tinea pedis
Recurrence and few hair；
（2）The present invention a kind of can be covered on damaged skin surface so as to not in the component of tinea pedis surface filming by manufacturing
By extraneous bacterial infestation, there is good water vapor transmittance and permeability, medicine will not be caused skin to be caused to do after air-drying
It is dry shortage moisture and it is uncomfortable, closely pasted after tinea pedis surface spraying or smearing, film forming in skin surface, effective over foot
Tinea surface simultaneously provides a suitable moist environment, and the medicine for treating tinea pedis is wrapped in film, is attached to tinea pedis surface, so that
Enter medicine, effective ingredient not easily runs off, so as to promote tinea pedis to heal；
（3）The present invention has the mycostatic effect of suppression by making topical agent, boric acid, and salicylic acid can suppress fungi, softening epidermis,
Exfoliating, methenamine hidroschesis, convergence, zinc oxide is antipruritic, convergence, and phenol sterilization has disinfection, metronidazole anaerobe resistant sense
Dye, nitrofurazone play the role of anti-inflammatory, and this product is nonirritant to the ulceration surface of a wound, painless, easy to apply to form a film in skin surface,
Then play a role quickly, make medicine be adhere tightly to skin surface and non-greasy, it is not easy to pollute footgear, B parts can be at the same time
It is coated in footwear, the bacterium in footwear is killed in the lump, the moment keeps foot's health.
Embodiment
A kind of preparation method of two-component treatment tinea pedis medicine, it is characterised in that including A parts, B parts, preparation A parts described
Method includes the following steps：
（1）Count in parts by weight, take 10 ~ 15 parts of Chinese yam, 8 ~ 9 parts of radix glycyrrhizae, 20 ~ 30 parts of kuh-seng, 12 ~ 15 parts of Cortex Phellodendri, the root of Chinese clematis 7 ~ 9
Part, 7 ~ 9 parts of alumen, 12 ~ 18 parts of luffa, adds 3000 parts of 1 ~ 2h of immersion of distilled water, obtains soaked medicinal material, will be soaked
Put into interlayer stainless steel medicinal cupping, lead to steam, be warming up to 90 ~ 100 DEG C, keep 0.5 kilogram of air pressure to decoct 30 ~ 40min, will decoct
Good admixing medical solutions are cooled to room temperature, and 4 ~ 5 layers of filtered through gauze of admixing medical solutions will have been decocted after cooling, filtrate has been taken, filtrate is placed in
3 ~ 5h in 80 ~ 85 DEG C of water bath with thermostatic control, obtains Chinese herbs decoction；
（2）Take wheat bran in mass ratio 1：8 add in the hydrochloric acid solution that mass fraction is 0.2mol/L, wheat bran mixed liquor are obtained, by wheat
Bran mixed liquor is placed in ultrasonic cell disruptor, 10 ~ 15min of ultrasound, protection temperature be 50 ~ 60 DEG C, obtain it is ultrasonic after mix it is molten
Liquid, centrifuges 7 ~ 9min by mixed solution after ultrasound, takes supernatant concentration, obtain vitamin B1 extracting solution；
（3）By above-mentioned Chinese herbs decoction and vitamin B1 extracting solution in mass ratio 5：3 mixing, stir evenly, obtain A parts；
Preparation method B parts described includes the following steps：
C. by polyether Glycols PPG1000 and PPG200 in mass ratio 1：2 are uniformly mixed, in 105 ~ 110 DEG C, -0.95MPa vacuum
Under the conditions of 1 ~ 2h of dehydration, obtain dehydrating mixt, dehydrating mixt be cooled to 40 ~ 50 DEG C, by isophorone diisocyanate
Ester in mass ratio 2：3 add to after cooling in dehydrating mixt, and 2 ~ 3h is reacted at 80 ~ 90 DEG C, reactant is obtained, is pressed into reactant
Mass ratio 5：2 add octoate catalyst stannous, carry out prepolymerization reaction, obtain prepolymerization reaction product, matter is pressed into prepolymerization reaction product
Measure ratio 6：1 adds acetone dilution, prepolymerization reaction product after must diluting, successively to prepolymerization reaction product in mass ratio 5 after dilution：3：
2 add chain extender 1,4-butanediol and dimethylolpropionic acid progress chain extending reaction, react 2 ~ 3h at 70 ~ 80 DEG C, obtain chain extending reaction
Thing, in mass ratio 3：5 add ethanol solution into chain extending reaction thing, and vacuum distillation, must remove acetone chain extending reaction thing, to removing acetone
In mass ratio 5 in chain extending reaction thing：3 add absolute ethyl alcohol, obtain alcohol-soluble polyurethane solution；
D. according to the mass fraction, 100 ~ 150 parts of salicylic acid, 30 ~ 40 parts of benzoic acid, 10 ~ 13 parts of boric acid, methenamine 20 ~ 30 are taken
Part, 15 ~ 20 parts of zinc oxide, 20 ~ 25 parts of phenol, 10 ~ 12 parts of metronidazole, 10 ~ 15 parts of nitrofurazone, 25 ~ 30 parts of triethanolamine, alcohol
50 ~ 70 parts of soluble polyurethane solution, 40 ~ 50 parts of water, stirs evenly, and obtains B parts；
A kind of application method of two-component treatment tinea pedis medicine, includes the following steps：
A parts：It is oral, 2 times/d, each 150mL, treat 3 ~ 4 weeks；B parts：External application, spreads at tinea pedis, and 2 ~ 3 times daily.
Embodiment 1
A kind of preparation method of two-component treatment tinea pedis medicine, it is characterised in that including A parts, B parts, preparation method A parts described
Include the following steps：
（1）Count in parts by weight, take 10 parts of Chinese yam, 8 parts of radix glycyrrhizae, 20 parts of kuh-seng, 12 parts of Cortex Phellodendri, 7 parts of the root of Chinese clematis, 7 parts of alumen, silk
12 parts of melon network, adds 3000 parts of immersion 1h of distilled water, obtains soaked medicinal material, put into soaked in interlayer stainless steel medicinal cupping,
Logical steam, is warming up to 90 DEG C, keeps 0.5 kilogram of air pressure to decoct 30min, will decoct admixing medical solutions and be cooled to room temperature, will cool down
After decocted 4 layers of filtered through gauze of admixing medical solutions, take filtrate, filtrate be placed in 3h in 80 ~ 85 DEG C of water bath with thermostatic control, Chinese medicine is obtained and decocts
Agent；
（2）Take wheat bran in mass ratio 1：8 add in the hydrochloric acid solution that mass fraction is 0.2mol/L, wheat bran mixed liquor are obtained, by wheat
Bran mixed liquor is placed in ultrasonic cell disruptor, ultrasonic 10min, and protection temperature is 50 DEG C, obtain it is ultrasonic after mixed solution, will be super
Mixed solution centrifuges 7min after sound, takes supernatant concentration, obtains vitamin B1 extracting solution；
（3）By above-mentioned Chinese herbs decoction and vitamin B1 extracting solution in mass ratio 5：3 mixing, stir evenly, obtain A parts；
Preparation method B parts described includes the following steps：
E. by polyether Glycols PPG1000 and PPG200 in mass ratio 1：2 are uniformly mixed, in 105 DEG C, -0.95MPa vacuum conditions
Lower dehydration 1h, obtains dehydrating mixt, dehydrating mixt is cooled to 40 DEG C, by isophorone diisocyanate in mass ratio
2：3 add to after cooling in dehydrating mixt, react 2h at 80 DEG C, obtain reactant, into reactant in mass ratio 5：2 additions are urged
Agent stannous octoate, carries out prepolymerization reaction, prepolymerization reaction product is obtained, into prepolymerization reaction product in mass ratio 6：1 adds acetone
Dilution, prepolymerization reaction product after must diluting, successively to prepolymerization reaction product in mass ratio 5 after dilution：3：2 add chain extender 1,4-
Butanediol and dimethylolpropionic acid carry out chain extending reaction, react 2h at 70 DEG C, obtain chain extending reaction thing, in mass ratio 3：5 to chain extension
Ethanol solution is added in reactant, is evaporated under reduced pressure, acetone chain extending reaction thing must be removed, to going in acetone chain extending reaction thing in mass ratio
5：3 add absolute ethyl alcohol, obtain alcohol-soluble polyurethane solution；
F. according to the mass fraction, 100 parts of salicylic acid is taken, 30 parts of benzoic acid, 10 parts of boric acid, 20 parts of methenamine, 15 parts of zinc oxide,
20 parts of phenol, 10 parts of metronidazole, 10 parts of nitrofurazone, 25 parts of triethanolamine, 50 parts of alcohol-soluble polyurethane solution, 40 parts of water, is stirred
Mix uniformly, obtain B parts；
A kind of application method of two-component treatment tinea pedis medicine, includes the following steps：
A parts：It is oral, 2 times/d, each 150mL, treat 3 weeks；B parts：External application, spreads at tinea pedis, and 2 times daily.
Embodiment 2
A kind of preparation method of two-component treatment tinea pedis medicine, it is characterised in that including A parts, B parts, preparation method A parts described
Include the following steps：
（1）Count in parts by weight, take 12 parts of Chinese yam, 8 parts of radix glycyrrhizae, 25 parts of kuh-seng, 13 parts of Cortex Phellodendri, 7 parts of the root of Chinese clematis, 7 parts of alumen, silk
16 parts of melon network, adds 3000 parts of immersion 1h of distilled water, obtains soaked medicinal material, put into soaked in interlayer stainless steel medicinal cupping,
Logical steam, is warming up to 95 DEG C, keeps 0.5 kilogram of air pressure to decoct 35min, will decoct admixing medical solutions and be cooled to room temperature, will cool down
After decocted 4 layers of filtered through gauze of admixing medical solutions, take filtrate, filtrate be placed in 4h in 83 DEG C of water bath with thermostatic control, obtains Chinese herbs decoction；
（2）Take wheat bran in mass ratio 1：8 add in the hydrochloric acid solution that mass fraction is 0.2mol/L, wheat bran mixed liquor are obtained, by wheat
Bran mixed liquor is placed in ultrasonic cell disruptor, ultrasonic 13min, and protection temperature is 55 DEG C, obtain it is ultrasonic after mixed solution, will be super
Mixed solution centrifuges 8min after sound, takes supernatant concentration, obtains vitamin B1 extracting solution；
（3）By above-mentioned Chinese herbs decoction and vitamin B1 extracting solution in mass ratio 5：3 mixing, stir evenly, obtain A parts；
Preparation method B parts described includes the following steps：
G. by polyether Glycols PPG1000 and PPG200 in mass ratio 1：2 are uniformly mixed, in 17 DEG C, -0.95MPa vacuum conditions
Lower dehydration 1h, obtains dehydrating mixt, dehydrating mixt is cooled to 45 DEG C, by isophorone diisocyanate in mass ratio
2：3 add to after cooling in dehydrating mixt, react 2h at 85 DEG C, obtain reactant, into reactant in mass ratio 5：2 additions are urged
Agent stannous octoate, carries out prepolymerization reaction, prepolymerization reaction product is obtained, into prepolymerization reaction product in mass ratio 6：1 adds acetone
Dilution, prepolymerization reaction product after must diluting, successively to prepolymerization reaction product in mass ratio 5 after dilution：3：2 add chain extender 1,4-
Butanediol and dimethylolpropionic acid carry out chain extending reaction, react 2h at 75 DEG C, obtain chain extending reaction thing, in mass ratio 3：5 to chain extension
Ethanol solution is added in reactant, is evaporated under reduced pressure, acetone chain extending reaction thing must be removed, to going in acetone chain extending reaction thing in mass ratio
5：3 add absolute ethyl alcohol, obtain alcohol-soluble polyurethane solution；
H. according to the mass fraction, 1 part of salicylic acid, 35 parts of benzoic acid, 12 parts of boric acid, 25 parts of methenamine, 17 parts of zinc oxide, benzene are taken
22 parts of phenol, 11 parts of metronidazole, 13 parts of nitrofurazone, 27 parts of triethanolamine, 60 parts of alcohol-soluble polyurethane solution, 45 parts of water, stirring
Uniformly, B parts are obtained；
A kind of application method of two-component treatment tinea pedis medicine, includes the following steps：
A parts：It is oral, 2 times/d, each 150mL, treat 3 weeks；B parts：External application, spreads at tinea pedis, and 2 times daily.
Embodiment 3
A kind of preparation method of two-component treatment tinea pedis medicine, it is characterised in that including A parts, B parts, preparation method A parts described
Include the following steps：
（1）Count in parts by weight, take 15 parts of Chinese yam, 9 parts of radix glycyrrhizae, 30 parts of kuh-seng, 15 parts of Cortex Phellodendri, 9 parts of the root of Chinese clematis, 9 parts of alumen, silk
18 parts of melon network, adds 3000 parts of immersion 2h of distilled water, obtains soaked medicinal material, put into soaked in interlayer stainless steel medicinal cupping,
Logical steam, is warming up to 100 DEG C, keeps 0.5 kilogram of air pressure to decoct 40min, will decoct admixing medical solutions and be cooled to room temperature, will cool down
After decocted 5 layers of filtered through gauze of admixing medical solutions, take filtrate, filtrate be placed in 5h in 85 DEG C of water bath with thermostatic control, obtains Chinese herbs decoction；
（2）Take wheat bran in mass ratio 1：8 add in the hydrochloric acid solution that mass fraction is 0.2mol/L, wheat bran mixed liquor are obtained, by wheat
Bran mixed liquor is placed in ultrasonic cell disruptor, ultrasonic 15min, and protection temperature is 60 DEG C, obtain it is ultrasonic after mixed solution, will be super
Mixed solution centrifuges 9min after sound, takes supernatant concentration, obtains vitamin B1 extracting solution；
（3）By above-mentioned Chinese herbs decoction and vitamin B1 extracting solution in mass ratio 5：3 mixing, stir evenly, obtain A parts；
Preparation method B parts described includes the following steps：
I. by polyether Glycols PPG1000 and PPG200 in mass ratio 1：2 are uniformly mixed, in 110 DEG C, -0.95MPa vacuum conditions
Lower dehydration 2h, obtains dehydrating mixt, dehydrating mixt is cooled to 50 DEG C, by isophorone diisocyanate in mass ratio
2：3 add to after cooling in dehydrating mixt, react 3h at 90 DEG C, obtain reactant, into reactant in mass ratio 5：2 additions are urged
Agent stannous octoate, carries out prepolymerization reaction, prepolymerization reaction product is obtained, into prepolymerization reaction product in mass ratio 6：1 adds acetone
Dilution, prepolymerization reaction product after must diluting, successively to prepolymerization reaction product in mass ratio 5 after dilution：3：2 add chain extender 1,4-
Butanediol and dimethylolpropionic acid carry out chain extending reaction, react 3h at 80 DEG C, obtain chain extending reaction thing, in mass ratio 3：5 to chain extension
Ethanol solution is added in reactant, is evaporated under reduced pressure, acetone chain extending reaction thing must be removed, to going in acetone chain extending reaction thing in mass ratio
5：3 add absolute ethyl alcohol, obtain alcohol-soluble polyurethane solution；
J. according to the mass fraction, 150 parts of salicylic acid is taken, 40 parts of benzoic acid, 13 parts of boric acid, 30 parts of methenamine, 20 parts of zinc oxide,
25 parts of phenol, 12 parts of metronidazole, 15 parts of nitrofurazone, 30 parts of triethanolamine, 70 parts of alcohol-soluble polyurethane solution, 50 parts of water, is stirred
Mix uniformly, obtain B parts；
A kind of application method of two-component treatment tinea pedis medicine, includes the following steps：
A parts：It is oral, 2 times/d, each 150mL, treat 4 weeks；B parts：External application, spreads at tinea pedis, and 3 times daily.
Drug test correlation circumstance prepared by the present invention is as follows
Method：30 patients are selected, only use A parts of medicines, are taken orally, 2 times/d, each 150mL, is treated 3 ~ 4 weeks, is detected it and control
Therapeutic effect.
Treat the specific detection case of the medicine such as table 1 of tinea pedis
Table 1
| It is effective（Example） | 9 |
| Improve（Example） | 15 |
| It is invalid（Example） | 6 |
| Effective time（d） | 30 |
From the foregoing, it will be observed that only using A parts of medicine, tinea pedis is treated by oral method, has certain effect, effective persistence is good.
Method：30 patients are selected, only use B parts of medicine, external application, spreads at tinea pedis, and 2 ~ 3 times daily, detects it and controls
Therapeutic effect.
Treat the specific detection case of the medicine such as table 2 of tinea pedis
Table 2
| It is effective（Example） | 12 |
| Improve（Example） | 17 |
| It is invalid（Example） | 1 |
| Effective time（d） | 32 |
From the foregoing, it will be observed that only using B parts of medicine, tinea pedis is treated by outer coating method, therapeutic effect is good, and effective persistence is good.
Comparative example：The treatment tinea pedis medicine of Zhengzhou bio tech ltd production
Method：The medicine for the treatment tinea pedis that embodiment is produced with comparative example is chosen, selects 400 experiments for having serious tinea pedis
Person, is classified as 4 groups, respectively using embodiment and the treatment tinea pedis medicine prepared by comparative example, is treated by its application method, experiment
After, detect the treatment of its tinea pedis.
Treat the specific detection case of the medicine such as table 3 of tinea pedis
Table 3
| Detection project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example |
| It is basic to cure（Example） | 40 | 47 | 58 | 18 |
| It is effective（Example） | 39 | 36 | 32 | 29 |
| Improve（Example） | 21 | 17 | 10 | 23 |
| It is invalid（Example） | 0 | 0 | 0 | 30 |
| It is efficient（%） | 79 | 83 | 90 | 47 |
Note：It is efficient to add effective statistics to fully recover.
From the foregoing, it will be observed that high efficiency of the medicine of the treatment tinea pedis prepared by the present invention in treatment tinea pedis situation, persistently
Performance is good, is the medicine of a kind of safety and efficient treatment tinea pedis, is worthy to be popularized and uses.
Claims (6)
- A kind of 1. preparation method of two-component treatment tinea pedis medicine, it is characterised in that including A parts, B parts, preparation side A parts described Method includes the following steps：According to the mass fraction, 10 ~ 15 parts of Chinese yam, 8 ~ 9 parts of radix glycyrrhizae are taken, 20 ~ 30 parts of kuh-seng, 12 ~ 15 parts of Cortex Phellodendri, 7 ~ 9 parts of the root of Chinese clematis, 7 ~ 9 parts of alumen, 12 ~ 18 parts of luffa, adds 3000 parts of 1 ~ 2h of immersion of distilled water, soaked medicinal material is obtained, by soaked input In interlayer stainless steel medicinal cupping, lead to steam, be warming up to 90 ~ 100 DEG C, decoct, admixing medical solutions will have been decocted and be cooled to room temperature, will have been cooled down After decocted 4 ~ 5 layers of filtered through gauze of admixing medical solutions, take filtrate, filtrate be placed in 3 ~ 5h in 80 ~ 85 DEG C of water bath with thermostatic control, in obtaining Medicine decoction；Take wheat bran to add in the hydrochloric acid solution that mass fraction is 0.2mol/L, obtain wheat bran mixed liquor, wheat bran mixed liquor is placed in super In sound wave cell disruptor, ultrasound, obtain it is ultrasonic after mixed solution, mixed solution after ultrasound is centrifuged, takes supernatant concentration, must be tieed up Raw element B1 extracting solutions；Above-mentioned Chinese herbs decoction is mixed with vitamin B1 extracting solution, is stirred evenly, up to A parts；Preparation method B parts described includes the following steps：Polyether Glycols PPG1000 and PPG200 are uniformly mixed, dehydration, obtains dehydrating mixt, and dehydrating mixt is dropped Temperature, isophorone diisocyanate is added to after cooling down in dehydrating mixt, reaction, obtains reactant, added into reactant pungent Sour stannous, carries out prepolymerization reaction, obtains prepolymerization reaction product, and acetone dilution, pre-polymerization after must diluting are added into prepolymerization reaction product Reaction product, adds chain extender 1,4-butanediol and dimethylolpropionic acid, reaction, must expand to prepolymerization reaction product after dilution successively Chain reaction thing, ethanol solution is added into chain extending reaction thing, and vacuum distillation, must remove acetone chain extending reaction thing, to removing acetone chain extension Absolute ethyl alcohol is added in reactant, obtains alcohol-soluble polyurethane solution；Count in parts by weight, take 100 ~ 150 parts of salicylic acid, 30 ~ 40 parts of benzoic acid, 10 ~ 13 parts of boric acid, 20 ~ 30 parts of methenamine, 15 ~ 20 parts of zinc oxide, 20 ~ 25 parts of phenol, 10 ~ 12 parts of metronidazole, 10 ~ 15 parts of nitrofurazone, 25 ~ 30 parts of triethanolamine, alcohol is molten 50 ~ 70 parts of polyurethane solutions of property, 40 ~ 50 parts of water stir evenly, and obtain B parts.
- 2. the preparation method of two-component treatment tinea pedis medicine according to claim 1, it is characterised in that the step（1）In The condition that steam decocts keeps 0.5 kilogram of air pressure to decoct 30 ~ 40min to be warming up to 90 ~ 100 DEG C.
- 3. the preparation method of two-component treatment tinea pedis medicine according to claim 1, it is characterised in that the step（2）In The mass ratio for the hydrochloric acid solution that wheat bran is 0.2mol/L with mass fraction is 1：8；Ultrasound condition is 10 ~ 15min of ultrasound, protection temperature Spend for 50 ~ 60 DEG C.
- 4. the preparation method of two-component treatment tinea pedis medicine according to claim 1, it is characterised in that the step（3）In The mass ratio of medicine decoction and vitamin B1 extracting solution is 5：3.
- 5. the preparation method of two-component treatment tinea pedis medicine according to claim 1, it is characterised in that gather in the step a The mass ratio of ether dihydric alcohol PPG1000 and PPG200 are 1：2；Dehydration conditions are：In 105 ~ 110 DEG C, -0.95MPa vacuum conditions 1 ~ 2h of lower dehydration；The mass ratio of isophorone diisocyanate and dehydrating mixt after cooling is 2：3；Reactant and octanoic acid The mass ratio of stannous is 5：2；The mass ratio of prepolymerization reaction product and acetone is 6：1；Prepolymerization reaction product, 1,4- fourths two after dilution The mass ratio of alcohol and dimethylolpropionic acid is 5：3：2；The mass ratio of chain extending reaction thing and ethanol solution is 3：5；Remove acetone chain extension The mass ratio of reactant and absolute ethyl alcohol is 5：3.
- 6. according to claim 1, it is characterised in that the application method of two-component treatment tinea pedis medicine is：A parts：Mouthful Clothes, 2 times/d, 150 mL, warmly takes every time, treats 3 ~ 4 weeks；B parts：External application, spreads at tinea pedis, and 2 ~ 3 times daily.
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| CN110051690A (en) * | 2019-05-21 | 2019-07-26 | 楼陆军 | A kind of compound medicine for treating tinea pedis and preparation method thereof, application |
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| CN102224975A (en) * | 2011-06-16 | 2011-10-26 | 相洪臣 | Soaking liquid medicine for treating tinea manus and pedis and medical healthcare product |
| CN103450440A (en) * | 2013-09-03 | 2013-12-18 | 山东天庆科技发展有限公司 | Waterborne polyurethane resin and preparation method thereof |
| CN107198699A (en) * | 2017-05-30 | 2017-09-26 | 胡建锋 | A kind of tinea pedis frost for treating tinea pedis |
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| US20020044979A1 (en) * | 2000-08-26 | 2002-04-18 | Pharmaceutical Industry Technology And Development Center | Anti-fungal pharmaceutical compositions comprising an active ingredient prepared from Zingiber officinal |
| CN102224975A (en) * | 2011-06-16 | 2011-10-26 | 相洪臣 | Soaking liquid medicine for treating tinea manus and pedis and medical healthcare product |
| CN103450440A (en) * | 2013-09-03 | 2013-12-18 | 山东天庆科技发展有限公司 | Waterborne polyurethane resin and preparation method thereof |
| CN107198699A (en) * | 2017-05-30 | 2017-09-26 | 胡建锋 | A kind of tinea pedis frost for treating tinea pedis |
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| CN110051690A (en) * | 2019-05-21 | 2019-07-26 | 楼陆军 | A kind of compound medicine for treating tinea pedis and preparation method thereof, application |
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