CN107998233A - A kind of Chinese medicine composition for treating osteoporosis and preparation method thereof - Google Patents

A kind of Chinese medicine composition for treating osteoporosis and preparation method thereof Download PDF

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CN107998233A
CN107998233A CN201711295541.1A CN201711295541A CN107998233A CN 107998233 A CN107998233 A CN 107998233A CN 201711295541 A CN201711295541 A CN 201711295541A CN 107998233 A CN107998233 A CN 107998233A
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chinese medicine
medicine composition
osteoporosis
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代立新
代哲尘
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Abstract

The invention discloses a kind of Chinese medicine composition for treating osteoporosis and preparation method thereof, wherein, the Chinese medicine composition is made of the Chinese medicine material that following parts by weight match：15 20 parts of psoralea corylifolia, 10 25 parts of the bark of eucommia, 10 25 parts of teasel root, 20 30 parts of saline cistanche, 15 30 parts of reticulate millettia, plays both sides of the street 10 35 parts, 20 30 parts of rhizoma homalonemae, 15 20 parts of Radix Paeoniae Alba, 20 35 parts of radix astragali, 10 15 parts of Angelica sinensis, 15 20 parts of cortex acanthopanacis, 10 15 parts of semen brassicae, 10 15 parts of Ligusticum wallichii, 6 10 parts of radix glycyrrhizae.The Chinese medicine composition of the treatment osteoporosis of the present invention, compatibility is reasonable, has no toxic side effect, and can fundamentally treat osteoporosis, especially senile osteoporosis, and efficacy stability is uneasy to recur.

Description

A kind of Chinese medicine composition for treating osteoporosis and preparation method thereof
Technical field
Patent of the present invention is related to the technical field for treating osteoporosis, especially a kind of Chinese traditional medicine composition for treating osteoporosis Thing and preparation method thereof, belongs to the field of Chinese medicines.
Background technology
Osteoporosis is due to that bone density caused by many reasons and bone mass decline, and bone micro-structure destroys, and causes bone Brittleness increase, so that the systemic osteopathy easily fractured.Osteoporosis is divided into two major class of primary and Secondary cases.It is primary Property osteoporosis is divided into Postmenopausal Osteoporosis (I type), senile osteoporosis (II type) and idiopathic sclerotin and dredges again Three kinds of loose (including juvenile).Postmenopausal Osteoporosis was typically occurred in after postmenopausal women in 5~10 years；Senile sclerotin Osteoporosis refer generally to the osteoporosis that old man occurs after 70 years old；And idiopathic osteoporosis occurs mainly in teenager, the cause of disease is still It is unknown.Common disease factor：Endocrine system disease, connective tissue disease, chronic renal disease, stomach and intestine and nutritive disease, hematological system Disease, neuromuscular system diseases cause；Common sympton：Pain, height shorten, bow-backed, and fracture, respiratory function declines.
Oteoporosis pain can reduce the quality of life of patient in itself, and deformation of spinal column, fracture can disable, make patient activity by Limit, can't take care of oneself, increase pulmonary infection, bedsore incidence, not only influence the quality of life of patient, also give personal, family Heavy financial burden is brought with society.
The method of existing treatment osteoporosis is to use western medicine mostly, and treatment cycle is long and easily recurs, Wu Fagen Control, treatment repeatedly causes patient suffering can't bear.Based on this, how to realize that the safety and stability treatment of osteoporosis is art technology The current technical issues that need to address of personnel.
The content of the invention
For the problems of the prior art, the invention aims to provide a kind of Chinese medicine composition for treating osteoporosis And preparation method thereof.
In order to achieve the above object, the technical scheme is that：
A kind of Chinese medicine composition for treating osteoporosis, the Chinese medicine material matched by following parts by weight form：Psoralea corylifolia 15-20 parts, 10-25 parts of the bark of eucommia, 10-25 parts of teasel root, 20-30 parts of saline cistanche, 15-30 parts of reticulate millettia, plays both sides of the street 10-35 parts, and thousand Year is 20-30 parts strong, 15-20 parts of Radix Paeoniae Alba, 20-35 parts of radix astragali, 10-15 parts of Angelica sinensis, 15-20 parts of cortex acanthopanacis, 10-15 parts of semen brassicae, 10-15 parts of Ligusticum wallichii, 6-10 parts of radix glycyrrhizae.
As preference, the Chinese medicine composition for the treatment of osteoporosis of the present invention, is matched by following parts by weight Chinese medicine material forms：17-19 parts of psoralea corylifolia, 15-22 parts of the bark of eucommia, 15-22 parts of teasel root, 22-28 parts of saline cistanche, reticulate millettia 18-28 Part, play both sides of the street 15-30 parts, 22-28 parts of rhizoma homalonemae, 16-19 parts of Radix Paeoniae Alba, 25-30 parts of radix astragali, 12-14 parts of Angelica sinensis, cortex acanthopanacis 16- 19 parts, 12-14 parts of semen brassicae, 12-14 parts of Ligusticum wallichii, 7-9 parts of radix glycyrrhizae.
As preference, the Chinese medicine composition for the treatment of osteoporosis of the present invention, is matched by following parts by weight Chinese medicine material forms：18 parts of psoralea corylifolia, 20 parts of the bark of eucommia, 20 parts of teasel root, 25 parts of saline cistanche, 25 parts of reticulate millettia, plays both sides of the street 28 parts, and thousand Year is 25 parts strong, 18 parts of Radix Paeoniae Alba, 27 parts of radix astragali, 13 parts of Angelica sinensis, 18 parts of cortex acanthopanacis, 13 parts of semen brassicae, 13 parts of Ligusticum wallichii, 8 parts of radix glycyrrhizae.
As preference, the Chinese medicine composition for the treatment of osteoporosis of the present invention, is matched by following parts by weight Chinese medicine material forms：16 parts of psoralea corylifolia, 13 parts of the bark of eucommia, 13 parts of teasel root, 21 parts of saline cistanche, 16 parts of reticulate millettia, plays both sides of the street 13 parts, and thousand Year is 21 parts strong, 17 parts of Radix Paeoniae Alba, 23 parts of radix astragali, 11 parts of Angelica sinensis, 17 parts of cortex acanthopanacis, 11 parts of semen brassicae, 11 parts of Ligusticum wallichii, 6 parts of radix glycyrrhizae.
Invention also provides a kind of preparation method of the Chinese medicine composition for the treatment of osteoporosis as described above, including Following steps：
1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, Angelica sinensis, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, are put into marmite after mixing, add 1000~1500ml's into marmite Water, soaks 30-60 minutes；
2) after boiling by intense fire, heated 20~30 minutes with slow boiling, after temperature slightly drops, take filtrate, the dregs of a decoction in marmite are standby With, and filtrate is poured into container, obtain first time liquid；
3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then slow boiling heating About 20 minutes, after temperature slightly drops, filtrate is taken, obtains second of liquid；
4) it well-done liquid will be put into same container, and be uniformly mixed twice, it is filling close after obtained liquid is sterilized Envelope, obtains Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take in three times within 1 day.Also can be 1 time Property decoct the dose of 2 days, filling and sealing after obtained liquid is sterilized, refrigeration, first pico- heating when taking.This Chinese medicine group Compound can also be prepared into powder capsule, specifically comprise the following steps：
1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, Angelica sinensis, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, will be uniformly mixed after the medicinal material drying of acquirement；
2) medicinal material in step 1) after mixing is ground into medicinal powder；
3) medicinal powder of step 2) is crossed into 500-800 mesh sieves and traditional Chinese medicine powder is made；
4) traditional Chinese medicine powder for obtaining step 3) put under ultraviolet light sterilizing 1 it is small when, obtain Chinese medicine composition medicinal powder；
5) Chinese medicine composition medicinal powder made from step 4) is fitted into capsulae vacuus and capsule is made, obtain Chinese medicine composition glue Capsule.
Chinese medicinal composition capsules prepared by the above method, instructions of taking are：Take in three times within 1 day, 15 grams every time (3).
Further, the preparation method of the Chinese medicine composition for the treatment of osteoporosis of the present invention, obtains in step 3) The granularity of traditional Chinese medicine powder be 600 mesh.
The Chinese medicine composition for the treatment of osteoporosis of the present invention, can be prepared into Chinese medicinal tablet, particle, traditional Chinese medicine pill etc. Diversified forms, are not limited to decoction and capsule, suitable for a variety of therapeutic modalities, application method.
Pharmacology of various herbs in the Chinese medicine composition of the treatment osteoporosis of the present invention is as follows：
Psoralea corylifolia：Acrid flavour, hardship；It is warm-natured；Enter spleen, kidney channel；Function：It is warming spleen and stopping diarrha, tonifying kidney and strengthening yang, astringent sperm contracting urine；Cure mainly：Spleen The cold of insufficiency type is rushed down, impotence due to deficiency of the kidney, frequent micturition of passing out semen, waist and knee crymodynia.
The bark of eucommia：It is sweet in flavor；It is warm-natured；Enter liver and kidney channel；Function：Filling liver kidney, strengthening the bones and muscles, tocolysis；Cure mainly：Soreness of waist and knee joint, muscles and bones without Power, fetal irritability, have a dizzy spell.
Teasel root：Taste：It is bitter, sweet；Property：Temperature；Enter liver and kidney channel；Function：Filling liver kidney, strengthening the bones and muscles, continues injured, only uterine bleeding；Cure mainly： Soreness and weakness of waist and knees, arthralgia pain due to rheumatism, uterine bleeding, threatened abortion, injury from falling down.
Saline cistanche：Taste：It is sweet, salty；Property：Temperature；Enter kidney, large intestine channel；Function：Kidney-replenishing, benefiting essence-blood, relax bowel；Cure mainly：Sun Impotence seminal emission, waist and knee crymodynia, muscles and bones are powerless, dry constipation of intestines.
Reticulate millettia：Taste：It is bitter；Property：Temperature；Enter liver and kidney channel；Function：Promoting circulation of blood and enriching blood, degrading the channel, strengthening the bones and muscles；Cure mainly：The deficiency of blood it Irregular menstruation, muscle is numb, and muscles and bones is powerless, soreness of waist and knee joint, the disease such as paralysis.
Play both sides of the street：Taste:It is bitter, puckery；Property：It is flat；Enter liver, bladder warp；Function：Dispersing liver-energy, degrading the channel, wind-damp dispelling, dredging water passages；It is main Control：Abdominal distention, irregular menstruation, breast knot, alactation, arthralgia pain due to rheumatism, extremity numbness, brothers' contraction, oedema, difficult urination, Carbuncle swells eczema.
Rhizoma homalonemae：Taste：It is pungent；Property：Temperature；Enter liver and kidney channel；Function：Wind-damp dispelling, strengthening the bones and muscles, analgesic；Cure mainly：Wind-cold-dampness arthralgia, limb Section is ached, numb, contraction, old man's muscle and bone ache.Treat for stomachache again.
Radix Paeoniae Alba：Taste：Bitter, acid；Property：It is cold；Enter liver, the spleen channel；Function：The moon, soft liver analgesic, suppressing liver-YANG are held back in blood-nourishing；Cure mainly：Month Through uncomfortable, uterine bleeding, abnormal sweating, gastral cavity abdomen shoot, pain over the hypochondriac region, four limbs contraction pain, dizziness of having a headache.
Radix astragali：It is sweet in flavor；It is warm-natured；Enter spleen, lung channel；Function：Invigorating qi for strengthening superficies, torr sore myogenic, Li Shui；Cure mainly：Deficient qi and blood, from Sweat, rush down prolapse of the anus for a long time, the prolapse of uterus, ephritis edema, albuminuria, diabetes, chronic ulcer.
Angelica sinensis：Taste：It is sweet, pungent, bitter；Property：Temperature；Enter liver, the heart, the spleen channel；Function：Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation； Cure mainly：Irregular menstruation, Amenorrhea abdominal pain, abdominal mass knot gather, uterine bleeding；Headache due to deficiency of blood, dizziness, Impotence numbness；Intestines are dry and shit is difficult, weight after dysentery characterized by blood in the stool；Carbuncle Subcutaneous ulcer sore is stolen, injury from falling down.
Cortex acanthopanacis：Taste：It is pungent, bitter；Property：Temperature；Enter liver and kidney channel；Function：Wind-damp dispelling, strengthening the bones and muscles；Cure mainly：Arthralgia pain due to rheumatism, waist and knee Weakness, tinea pedis, edema.
Semen brassicae：Taste：It is pungent；Property：Temperature；Enter stomach, lung channel；Function：Reduces phlegm by drink；Mass dissipating and swelling eliminating；Cure mainly：Cough and phlegm；Chest Full hypochondriac pain；Extremity numbness；Painful swelling of joints；Multiple abscess with damp phlegm；Cloudy subcutaneous ulcer pyogenic infections.
Ligusticum wallichii：Taste：It is pungent；Property：Temperature；Enter liver, courage, the heart channel of Hang-Shaoyin；Function：Blood-activating and qi-promoting, wind-expelling pain-stopping；Cure mainly：Irregular menstruation, warp Close dysmenorrhoea, abdominal mass abdominal pain, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Radix glycyrrhizae：It is sweet in flavor：It is mild-natured.The thoughts of returning home, spleen, lung, stomach.Function：Invigorate the spleen and benefit qi, moisten the lung and relieve the cough, clearing heat and detoxicating, alleviation stops Bitterly, drug effect is relaxed.Cure mainly：Weakness of the spleen and the stomach, shortness of breath and fatigue, palpitation and severe palpitation, cough phlegm is few, pathopyretic ulcer, medicine food poisoning, and gastral cavity abdomen is anxious Bitterly, four limbs contraction pain.
The Chinese medicine composition of the treatment osteoporosis of the present invention, with warming spleen and stopping diarrha, tonifying kidney and strengthening yang, the psoralea corylifolia of astringent sperm contracting urine For monarch drug in a prescription；With filling liver kidney, strengthening the bones and muscles, the bark of eucommia of tocolysis, filling liver kidney, strengthening the bones and muscles, continues injured, only the teasel root of uterine bleeding is old medicine；With Kidney-replenishing, benefiting essence-blood, the dried meat floss Rong to relax bowel, promoting circulation of blood and enriching blood, degrading the channel, the reticulate millettia of strengthening the bones and muscles, dispersing liver-energy, degrading the channel, Wind-damp dispelling, the playing both sides of the street of dredging water passages, wind-damp dispelling, strengthening the bones and muscles, the rhizoma homalonemae of analgesic, blood-nourishing hold back the moon, soft liver analgesic, suppressing liver-YANG Radix Paeoniae Alba, invigorating qi for strengthening superficies, torr sore myogenic, the radix astragali of Li Shui, benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, Angelica sinensis, the wind-damp dispelling of moisturize laxation, by force The cortex acanthopanacis of muscles and bones, reduces phlegm by drink；Semen brassicae, the blood-activating and qi-promoting of mass dissipating and swelling eliminating, the Ligusticum wallichii of wind-expelling pain-stopping is adjutant；With tonifying spleen benefit Gas, moistens the lung and relieve the cough, clearing heat and detoxicating, alleviates analgesic, and the radix glycyrrhizae for relaxing drug effect is to make medicine.The Chinese medicine of the treatment osteoporosis of the present invention Composition, compatibility is reasonable, has no toxic side effect, and can fundamentally treat osteoporosis, especially senile osteoporosis, and drug effect is steady It is fixed, it is uneasy to recur.
Embodiment
Below in conjunction with embodiment, the technical solution in the embodiment of the present invention is clearly and completely described.Obviously, Described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Based on the implementation in the present invention Example, those of ordinary skill in the art's all other embodiments obtained without making creative work, belongs to The scope of protection of the invention.
Embodiment one：
A kind of Chinese medicine composition for treating osteoporosis, the Chinese medicine material matched by following parts by weight form：Psoralea corylifolia 15 parts, 10 parts of the bark of eucommia, 10 parts of teasel root, 20 parts of saline cistanche, 15 parts of reticulate millettia, plays both sides of the street 10 parts, 20 parts of rhizoma homalonemae, 15 parts of Radix Paeoniae Alba, 20 parts of radix astragali, 10 parts of Angelica sinensis, 15 parts of cortex acanthopanacis, 10 parts of semen brassicae, 10 parts of Ligusticum wallichii, 6 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of osteoporosis as described above, bag at the same time Include following steps：
1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, Angelica sinensis, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, are put into marmite after mixing, and the water of 1200ml, immersion are added into marmite 30 minutes；
2) after boiling by intense fire, being heated 20 minutes with slow boiling, after temperature slightly drops, take filtrate, the dregs of a decoction in marmite are spare, and Filtrate is poured into container, obtains first time liquid；
3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then slow boiling heating About 20 minutes, after temperature slightly drops, filtrate is taken, obtains second of liquid；
4) it well-done liquid will be put into same container, and be uniformly mixed twice, it is filling close after obtained liquid is sterilized Envelope, obtains Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take at twice within 1 day.Also can be 1 time Property decoct the dose of 2 days, filling and sealing after obtained liquid is sterilized, refrigeration, first pico- heating when taking.
Embodiment two：
A kind of Chinese medicine composition for treating osteoporosis, the Chinese medicine material matched by following parts by weight form：Psoralea corylifolia 16 parts, 13 parts of the bark of eucommia, 13 parts of teasel root, 21 parts of saline cistanche, 16 parts of reticulate millettia, plays both sides of the street 13 parts, 21 parts of rhizoma homalonemae, 17 parts of Radix Paeoniae Alba, 23 parts of radix astragali, 11 parts of Angelica sinensis, 17 parts of cortex acanthopanacis, 11 parts of semen brassicae, 11 parts of Ligusticum wallichii, 6 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of osteoporosis as described above at the same time, including Following steps：
1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, Angelica sinensis, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, will be uniformly mixed after the medicinal material drying of acquirement；
2) medicinal material in step 1) after mixing is ground into medicinal powder；
3) medicinal powder of step 2) is crossed into 600 mesh sieves and traditional Chinese medicine powder is made；
4) traditional Chinese medicine powder for obtaining step 3) put under ultraviolet light sterilizing 1 it is small when, obtain Chinese medicine composition medicinal powder；
5) Chinese medicine composition medicinal powder made from step 4) is fitted into capsulae vacuus and capsule is made, obtain Chinese medicine composition glue Capsule.
Chinese medicinal composition capsules prepared by the above method, instructions of taking are：Take in three times within 1 day, 15 grams every time (3).
Embodiment three：
A kind of Chinese medicine composition for treating osteoporosis, the Chinese medicine material matched by following parts by weight form：Psoralea corylifolia 17 parts, 15 parts of the bark of eucommia, 15 parts of teasel root, 22 parts of saline cistanche, 18 parts of reticulate millettia, plays both sides of the street 15 parts, 22 parts of rhizoma homalonemae, 16 parts of Radix Paeoniae Alba, 25 parts of radix astragali, 12 parts of Angelica sinensis, 16 parts of cortex acanthopanacis, 12 parts of semen brassicae, 12 parts of Ligusticum wallichii, 7 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of osteoporosis as described above at the same time, including Following steps：
1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, Angelica sinensis, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, are put into marmite after mixing, and the water of 1300ml, immersion are added into marmite 45 minutes；
2) after boiling by intense fire, being heated 25 minutes with slow boiling, after temperature slightly drops, take filtrate, the dregs of a decoction in marmite are spare, and Filtrate is poured into container, obtains first time liquid；
3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then slow boiling heating About 25 minutes, after temperature slightly drops, filtrate is taken, obtains second of liquid；
4) it well-done liquid will be put into same container, and be uniformly mixed twice, it is filling close after obtained liquid is sterilized Envelope, obtains Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take at twice within 1 day.Also can be 1 time Property decoct the dose of 2 days, filling and sealing after obtained liquid is sterilized, refrigeration, first pico- heating when taking.
Example IV：
A kind of Chinese medicine composition for treating osteoporosis, the Chinese medicine material matched by following parts by weight form：Psoralea corylifolia 18 parts, 20 parts of the bark of eucommia, 20 parts of teasel root, 25 parts of saline cistanche, 25 parts of reticulate millettia, plays both sides of the street 28 parts, 25 parts of rhizoma homalonemae, 18 parts of Radix Paeoniae Alba, 27 parts of radix astragali, 13 parts of Angelica sinensis, 18 parts of cortex acanthopanacis, 13 parts of semen brassicae, 13 parts of Ligusticum wallichii, 8 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of osteoporosis as described above at the same time, including Following steps：
1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, Angelica sinensis, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, will be uniformly mixed after the medicinal material drying of acquirement；
2) medicinal material in step 1) after mixing is ground into medicinal powder；
3) medicinal powder of step 2) is crossed into 700 mesh sieves and traditional Chinese medicine powder is made；
4) traditional Chinese medicine powder for obtaining step 3) put under ultraviolet light sterilizing 1 it is small when, obtain Chinese medicine composition medicinal powder；
5) Chinese medicine composition medicinal powder made from step 4) is fitted into capsulae vacuus and capsule is made, obtain Chinese medicine composition glue Capsule.
Chinese medicinal composition capsules prepared by the above method, instructions of taking are：Take at twice within 1 day, 15 grams every time (3).
Embodiment five：
A kind of Chinese medicine composition for treating osteoporosis, the Chinese medicine material matched by following parts by weight form：Psoralea corylifolia 19 parts, 22 parts of the bark of eucommia, 22 parts of teasel root, 28 parts of saline cistanche, 28 parts of reticulate millettia, plays both sides of the street 30 parts, 28 parts of rhizoma homalonemae, 119 parts of Radix Paeoniae Alba, 30 parts of radix astragali, 14 parts of Angelica sinensis, 19 parts of cortex acanthopanacis, 14 parts of semen brassicae, 14 parts of Ligusticum wallichii, 9 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of osteoporosis as described above at the same time, including Following steps：
1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, Angelica sinensis, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, are put into marmite after mixing, and the water of 1500ml, immersion are added into marmite 60 minutes；
2) after boiling by intense fire, being heated 30 minutes with slow boiling, after temperature slightly drops, take filtrate, the dregs of a decoction in marmite are spare, and Filtrate is poured into container, obtains first time liquid；
3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then slow boiling heating About 30 minutes, after temperature slightly drops, filtrate is taken, obtains second of liquid；
4) it well-done liquid will be put into same container, and be uniformly mixed twice, it is filling close after obtained liquid is sterilized Envelope, obtains Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take in three times within 1 day.Also can be 1 time Property decoct the dose of 2 days, filling and sealing after obtained liquid is sterilized, refrigeration, first pico- heating when taking.
Embodiment six：
A kind of Chinese medicine composition for treating osteoporosis, it is characterised in that the Chinese medicine material matched by following parts by weight Composition：20 parts of psoralea corylifolia, 25 parts of the bark of eucommia, 25 parts of teasel root, 30 parts of saline cistanche, 30 parts of reticulate millettia, plays both sides of the street 35 parts, rhizoma homalonemae 30 Part, 20 parts of Radix Paeoniae Alba, 35 parts of radix astragali, 15 parts of Angelica sinensis, 20 parts of cortex acanthopanacis, 15 parts of semen brassicae, 15 parts of Ligusticum wallichii, 10 parts of radix glycyrrhizae.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of osteoporosis as described above at the same time, including Following steps：
1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, Angelica sinensis, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, will be uniformly mixed after the medicinal material drying of acquirement；
2) medicinal material in step 1) after mixing is ground into medicinal powder；
3) medicinal powder of step 2) is crossed into 600 mesh sieves and traditional Chinese medicine powder is made；
4) traditional Chinese medicine powder for obtaining step 3) put under ultraviolet light sterilizing 1 it is small when, obtain Chinese medicine composition medicinal powder；
5) Chinese medicine composition medicinal powder made from step 4) is fitted into capsulae vacuus and capsule is made, obtain Chinese medicine composition glue Capsule.
Chinese medicinal composition capsules prepared by the above method, instructions of taking are：Take at twice within 1 day, 10 grams every time (2).
The Chinese medicine composition of the treatment osteoporosis of the present invention, with warming spleen and stopping diarrha, tonifying kidney and strengthening yang, the psoralea corylifolia of astringent sperm contracting urine For monarch drug in a prescription；With filling liver kidney, strengthening the bones and muscles, the bark of eucommia of tocolysis, filling liver kidney, strengthening the bones and muscles, continues injured, only the teasel root of uterine bleeding is old medicine；With Kidney-replenishing, benefiting essence-blood, the dried meat floss Rong to relax bowel, promoting circulation of blood and enriching blood, degrading the channel, the reticulate millettia of strengthening the bones and muscles, dispersing liver-energy, degrading the channel, Wind-damp dispelling, the playing both sides of the street of dredging water passages, wind-damp dispelling, strengthening the bones and muscles, the rhizoma homalonemae of analgesic, blood-nourishing hold back the moon, soft liver analgesic, suppressing liver-YANG Radix Paeoniae Alba, invigorating qi for strengthening superficies, torr sore myogenic, the radix astragali of Li Shui, benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, Angelica sinensis, the wind-damp dispelling of moisturize laxation, by force The cortex acanthopanacis of muscles and bones, reduces phlegm by drink；Semen brassicae, the blood-activating and qi-promoting of mass dissipating and swelling eliminating, the Ligusticum wallichii of wind-expelling pain-stopping is adjutant；With tonifying spleen benefit Gas, moistens the lung and relieve the cough, clearing heat and detoxicating, alleviates analgesic, and the radix glycyrrhizae for relaxing drug effect is to make medicine.The Chinese medicine of the treatment osteoporosis of the present invention Composition, compatibility is reasonable, has no toxic side effect, and can fundamentally treat osteoporosis, especially senile osteoporosis, and drug effect is steady It is fixed, it is uneasy to recur.
The present invention has carried out clinical efficacy tracking with the data given by embodiment 3 at the same time, and curative effect is summarized as follows：
1. sufferers of osteoporosis face 80 is chosen, wherein male 45 female 35, age 40-75 Sui, average age 58 years old.
2. treatment method, treatment group takes orally Chinese medicine composition decoction made from optimization formula embodiment 3 of the present invention,
Take in three times daily, each 200ml, the course for the treatment of 20 days.Coordinating suitable movement, daily life rule, shines sunlight more, High calcareous diet.
3. diagnostic criteria：
3.1 with reference to World Health Organization's senile osteoporosis diagnostic criteria
1) clinical symptoms such as different degrees of the small of the back is ached, the whole body is weak are shown；
2) fracture under nonviolent conditions；
3) Binding experiment room checks and results of imaging, is osteoporosis more than 25% with bone loss, bone loss surpasses 25% is crossed, merges fracture or bone loss more than 37%, is severe osteoporosis.
3.2 tcm diagnosis standard
According to《New Chinese medicine guideline of clinical investigations》" new Chinese medicine treatment osteoporosis clinical research instruct The evaluation of principle " requires to formulate, and shows as：Lumbar vertebrae pain, aching and limp few power, walk with difficulty, vertigo, cannot be prudent, tongue nature Or partially red or light, the symptom such as thin lingual fur or thin white, deep thready pulse.
3. curative effect determinate standard：Reference《Traditional Chinese medical science osteoporosis magazine》、《Practical osteology》Deng evaluation.
1) cure：Clinical symptoms, sign disappear, and functional rehabilitation is normal, does not recur within more than 1 year；
2) it is effective：Clinical symptoms, sign substantially disappear, and function returns to normal；
3) effectively：Clinical symptoms, sign part mitigate；
4) it is invalid：Continuous treatment more than 30 days, symptom, sign are without change.
4. diagnostic result：
Clinical cure is effective 58 (72.5%), effective 10 (12.5%), invalid 3 (3.75%), and total effective rate is 85%.
The Chinese medicine composition of the treatment osteoporosis of the present invention, compatibility is reasonable, has no toxic side effect, and can fundamentally treat Osteoporosis, efficacy stability are uneasy to recur.
Toxicity test is carried out to the Chinese medicine composition of the present invention, test effect is as follows：
Select 18-22 grams of weight, the healthy mice of 16 week old (homogeneous test body heavy phase difference is no more than 2 grams).Rat 20 weeks Age；120-150 grams of weight, homogeneous test body heavy phase difference are no more than 10g.During experiment, animal is randomly divided into 4-5 groups by volume, Every group of at least 10 animals, to reaction of animals situation is observed after tested material at once, once, continuous observation 6 months, sees for observation daily Examine toxic reaction, should, pays attention to the record appearance of animal, behavioral activity, the state of mind, appetite (feed consumption), stool and urine and Its color, hair, the colour of skin, breathing, nose, eye, oral cavity secretion without exception, changes of weight etc., compared with control group, administration group is small White mouse physical condition is normal, and has no that small white mouse is sick or dead.Prompt the medicine security good, have no toxic side effect.
The treatment case of the Chinese medicine composition of the present invention is as follows：
Case one, Mr. Wang, male, 56 years old.Ache all over always many years ago, pain is along backbone to two side diffusions.Ache during seat Pain mitigate, when upright after stretch or long stand, sitting when the pain increased, pain is light in the daytime, and night and early morning aggravate when waking up, bend over, Muscular movement, cough, defecate and aggravated when exerting oneself, and is turned over when serious, rises to sit and walk and have any problem, stool and urine cannot take care of oneself, weight Appearance such as is become thin at the symptom, seeks doctor in many ways through household, and various folk prescriptions on probation, which are showed no, to prove effective, and the state of an illness has the tendency of exacerbation always, After the Chinese medicine composition two weeks for using the present invention afterwards, slight illness has mitigated, and continuously takes in the offer of the embodiment of the present invention four After one month, pain symptom disappears drug composition capsule substantially, can also carry out some simple manual labors.Controlled to consolidate Treat, by then taking one month, above-mentioned symptom all disappears.Visited after half a year, no recurrence.
Case two, Lee, man, 70 years old.Due to aching all over month after month throughout the year, early period is treated always, but non-root Control, with advancing age, osteoporosis aggravates, and bow-backed curvature increases, and knee joint contraction is arrested significantly, and having difficulty in breathing occurs in the later stage Symptom, after carry out many-sided treatment in hospital and do not improve, after the traditional Chinese herbal decoction one month of the offer of the embodiment of the present invention five is provided, Breathing improves, and pain symptom has mitigated, and continuously takes the Chinese medicine composition decoction two of the offer of the embodiment of the present invention five Month symptom disappears substantially, be after treatment, and then takes one month, above-mentioned symptom all disappearances.Visited after half a year, without multiple Hair.
Case three, Zhang, female, 48 years old.For many years, recurrent exerbation, especially winter, the state of an illness is even more serious for lumbocrural pain, Normal waking activity is unable to during standing, cannot smoothly be stood up after sitting, double lower limb numb pain, night loins is more cold, Chronic insomnia.Light purplish tongue tongue is thin white, stringy and tense pulse.Shown through X-ray：Lumbar curvature straightens, narrowing of intervertebral space.Take the present invention After the traditional Chinese herbal decoction two weeks that embodiment three provides, lumbocrural pain gradually mitigates, and after 20 days, can smoothly stand after sitting, and Can normally walk activity after standing, continue after taking two weeks, above-mentioned symptom all disappears, and recovers.Visited after half a year, without multiple Hair.
The foregoing description of the disclosed embodiments, enables those skilled in the art to realize or use the present invention.To this A variety of modifications of a little embodiments will be apparent for a person skilled in the art, and the general principles defined herein can Without departing from the spirit or scope of the present invention, to realize in other embodiments.Therefore, the present invention will not be limited The embodiments shown herein is formed on, and is to fit to consistent with the principles and novel features disclosed herein most wide Scope.

Claims (8)

  1. A kind of 1. Chinese medicine composition for treating osteoporosis, it is characterised in that the Chinese medicine material group matched by following parts by weight Into：15-20 parts of psoralea corylifolia, 10-25 parts of the bark of eucommia, 10-25 parts of teasel root, 20-30 parts of saline cistanche, 15-30 parts of reticulate millettia, plays both sides of the street 10-35 parts, 20-30 parts of rhizoma homalonemae, 15-20 parts of Radix Paeoniae Alba, 20-35 parts of radix astragali, 10-15 parts of Angelica sinensis, 15-20 parts of cortex acanthopanacis, sinapsis alba It is 10-15 parts sub-, 10-15 parts of Ligusticum wallichii, 6-10 parts of radix glycyrrhizae.
  2. 2. the Chinese medicine composition for the treatment of osteoporosis according to claim 1, it is characterised in that matched somebody with somebody by following parts by weight The Chinese medicine material composition of ratio：17-19 parts of psoralea corylifolia, 15-22 parts of the bark of eucommia, 15-22 parts of teasel root, 22-28 parts of saline cistanche, reticulate millettia 18-28 parts, play both sides of the street 15-30 parts, 22-28 parts of rhizoma homalonemae, 16-19 parts of Radix Paeoniae Alba, 25-30 parts of radix astragali, 12-14 parts of Angelica sinensis, slender acanthopanax 16-19 parts of skin, 12-14 parts of semen brassicae, 12-14 parts of Ligusticum wallichii, 7-9 parts of radix glycyrrhizae.
  3. 3. the Chinese medicine composition for the treatment of osteoporosis according to claim 1, it is characterised in that matched somebody with somebody by following parts by weight The Chinese medicine material composition of ratio：18 parts of psoralea corylifolia, 20 parts of the bark of eucommia, 20 parts of teasel root, 25 parts of saline cistanche, 25 parts of reticulate millettia play both sides of the street 28 Part, 25 parts of rhizoma homalonemae, 18 parts of Radix Paeoniae Alba, 27 parts of radix astragali, 13 parts of Angelica sinensis, 18 parts of cortex acanthopanacis, 13 parts of semen brassicae, 13 parts of Ligusticum wallichii, radix glycyrrhizae 8 Part.
  4. 4. the Chinese medicine composition for the treatment of osteoporosis according to claim 1, it is characterised in that matched somebody with somebody by following parts by weight The Chinese medicine material composition of ratio：16 parts of psoralea corylifolia, 13 parts of the bark of eucommia, 13 parts of teasel root, 21 parts of saline cistanche, 16 parts of reticulate millettia play both sides of the street 13 Part, 21 parts of rhizoma homalonemae, 17 parts of Radix Paeoniae Alba, 23 parts of radix astragali, 11 parts of Angelica sinensis, 17 parts of cortex acanthopanacis, 11 parts of semen brassicae, 11 parts of Ligusticum wallichii, radix glycyrrhizae 6 Part.
  5. 5. a kind of preparation method of the Chinese medicine composition for the treatment of osteoporosis as any one of claim 1-4, it is special Sign is, includes the following steps：
    1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, when Return, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, be put into after mixing in marmite, into marmite add 1000~1500ml water, Immersion 30-60 minutes；
    2) after boiling by intense fire, being heated 20~30 minutes with slow boiling, after temperature slightly drops, take filtrate, the dregs of a decoction in marmite are spare, and Filtrate is poured into container, obtains first time liquid；
    3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then slow boiling heating about 20 Minute, after temperature slightly drops, filtrate is taken, obtains second of liquid；
    4) it well-done liquid will be put into same container, and be uniformly mixed twice, filling and sealing after obtained liquid is sterilized, obtains To Traditional Chinese medicine composition liquid medicine.
  6. 6. a kind of preparation method of the Chinese medicine composition for the treatment of osteoporosis as any one of claim 1-4, it is special Sign is, includes the following steps：
    1) weigh by weight psoralea corylifolia, the bark of eucommia, teasel root, saline cistanche, reticulate millettia, play both sides of the street, rhizoma homalonemae, Radix Paeoniae Alba, radix astragali, when Return, cortex acanthopanacis, semen brassicae, Ligusticum wallichii, radix glycyrrhizae, will after the medicinal material drying of acquirement be uniformly mixed；
    2) medicinal material in step 1) after mixing is ground into medicinal powder；
    3) medicinal powder of step 2) is crossed into 500-800 mesh sieves and traditional Chinese medicine powder is made；
    4) traditional Chinese medicine powder for obtaining step 3) put under ultraviolet light sterilizing 1 it is small when, obtain Chinese medicine composition medicinal powder.
  7. 7. the preparation method of the Chinese medicine composition for the treatment of osteoporosis according to claim 6, it is characterised in that including such as Lower step：
    Chinese medicine composition medicinal powder made from step 4) is fitted into capsulae vacuus capsule is made, obtain Chinese medicinal composition capsules.
  8. 8. the preparation method of the Chinese medicine composition for the treatment of osteoporosis as claimed in claim 6, it is characterised in that in step 3) The granularity of obtained traditional Chinese medicine powder is 600 mesh.
CN201711295541.1A 2017-12-08 2017-12-08 A kind of Chinese medicine composition for treating osteoporosis and preparation method thereof Withdrawn CN107998233A (en)

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