CN107982286A - A kind of cordyceps sinensis lozenge and preparation method thereof - Google Patents
A kind of cordyceps sinensis lozenge and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
The present invention relates to Chinese medicine tabletting technology field, and in particular to a kind of cordyceps sinensis lozenge and preparation method thereof.The lozenge is by cordyceps sinensis, Cordyceps militaris composition.Formula using the present invention, can be differently configured from traditional wet granulation, and can not make pellet direct tablet compressing in the technique of tabletting, simplify processing step, obtained lozenge smooth appearance, best in quality, and can extend oral cavity action time.By implementing the present invention, the Cordyceps sinensis buccal tablets being prepared do not add the high adhesive of any sugar content, to avoiding because the long-term excessive people for eating sugar, causing human body to get fat and induce the diseases such as hypertension, diabetes, cardiovascular disease, nephrosis have good auxiliary curative effect, its health care and therapeutic effect are more notable.
Description
Technical field
The present invention relates to Chinese medicine tabletting technology field, and in particular to a kind of cordyceps sinensis lozenge and preparation method thereof.
Background technology
Cordyceps sinensis is a kind of combination of insect and fungi, and people are usually referred to as cordyceps sinensis.It is specialty in green grass or young crops
A kind of precious rare, nutritional ingredient on plateau and the Chinese medicine that healthcare function is splendid are hidden, China is collectively known as with ginseng, pilose antler
The three of invigorant are big precious.According to modern pharmacology research, Cordyceps of Qinghai Province contains cordycepic acid about 7%, protein about 25%, fat
About 8.4%, wherein 82.2% cannot synthesize and required unrighted acid for human body, supplied containing needed by human from food
The 8 kinds of amino acid given, histidine necessary to being developed containing physical growth of children.Additionally containing multi-vitamin B12, ergot fat
Alcohol, hexose alcohol, alkaloid etc..It, which has, adjusts the multiple efficacies such as function of immune system, antitumor, antifatigue.According to clinical report,
Cordyceps sinensis has effects that foster lung yin, kidney-replenishing, relieving cough and reducing sputum, anticancer are prevented old, and drug effect is gentle, and not attending a meeting like people makes one
Produce it is scorching, have the benefit of ginseng and the evil without ginseng.It is all without being avoided for the product of flat tonifying yin sun.Cordyceps sinensis traditional at present
Eating method has a variety of, and common mainly to have cordyceps sinensis medicine liqueur, cordyceps sinensis is soaked, decocts water, cordyceps medicinal food and milling etc., but only all stops
On the basis of simple, coarse, original, its utilization rate and to take effect bad causes greatly to waste.The pure powder system of cordyceps sinensis
Into lozenge, by oral cavity it is buccal when, because mucous membrane of mouth is dispersed with the most intensive capillary of human body, its essential ingredient can be absorbed and filled
Point, its absorption rate is high.However, at present the pure powder of cordyceps sinensis be made lozenge also there are it is many problem of：Shaping is poor, and surface is thick
Rough, easy dry linting can fater disintegration during mouth containing.
CN1356116 discloses a kind of Cordyceps sinensis buccal tablets, and compression molding is carried out as adhesive using auxiliary material Icing Sugar, dextrin, although
Obtained Cordyceps sinensis buccal tablets any surface finish, but cordyceps sinensis content is extremely low, less than 1%, and influences mouthfeel, diabetic and obesity
Person should not use, and reduce cordyceps sinensis quality and effect.
CN1439423 discloses a kind of Cordyceps sinensis buccal tablets, matches and is adjusted for cordyceps 5-45%, American Ginseng 1-20%, filling
Taste agent 0-35%, preparation process be by American Ginseng by selected, cleaning, dry and ultramicro grinding after, above two raw material and
Filling flavor enhancement is uniformly mixed, last compression molding.From its preferred embodiment 1 and 2 as can be seen that cordyceps sinensis only accounts for 45%, fill out
Fill flavor enhancement and account for more than 30%, equally existing diabetic and overweight people should not use, and reduce cordyceps sinensis quality and effect
Problem.
Therefore the pure powder content height of exploitation cordyceps sinensis, stable dosage forms, holding drug effect, the Cordyceps sinensis buccal tablets for improving mouthfeel are urgently to be resolved hurrily
The problem of.
The content of the invention
In order to solve the problems in the existing technology, the invention discloses a kind of cordyceps sinensis lozenge, including：
Cordyceps sinensis, Cordyceps militaris.
In a preferred embodiment, the cordyceps sinensis lozenge includes：
Cordyceps sinensis：45%-95%；
Cordyceps militaris：5%-55%.
In a preferred embodiment, the cordyceps sinensis lozenge includes：
Cordyceps sinensis：50%-95%；
Cordyceps militaris：5%-50%.
In a preferred embodiment, the cordyceps sinensis lozenge includes：
Cordyceps sinensis：65%-95%；
Cordyceps militaris：5%-35%.
In a preferred embodiment, the cordyceps sinensis lozenge includes：
Cordyceps sinensis：70%-91%；
Cordyceps militaris：9%-30%.
The cordyceps sinensis described in a specific embodiment and Cordyceps militaris mass ratio are (3-5)：1.
Formula using the present invention, can be differently configured from traditional wet granulation, can not make pellet in the technique of tabletting
Direct tablet compressing, simplifies processing step, obtained lozenge smooth appearance, best in quality, and can extend oral cavity action time.Increase
Add buccal time of the Cordyceps sinensis buccal tablets in mouth, you can to protect mucous membrane of mouth, promote the reparation of mucous membrane of mouth microlesion to subtract
Bad lesion caused by few chronic injury, can also greatly increase the absorption to cordyceps sinensis essential ingredient, reduce intestines and stomach
With the first pass effect of liver, essential ingredient is directly entered blood circulation, heightens the effect of a treatment.It can make absorption of the body to cordyceps sinensis
Rate is up to more than 95%.
In a specific embodiment, the cordyceps sinensis lozenge using the present invention that be prepared that matches can be notable
Mouse cell and humoral immunity ability, monocytes/macrophages function and NK cytoactives are improved, shows that the present invention is prepared
Cordyceps sinensis lozenge significantly increase normal mouse immunity.
On the other hand, the present invention provides a kind of preparation method of the cordyceps sinensis lozenge, include the following steps：
Take cordyceps sinensis of the water content not higher than 10% to be crushed to particle diameter mesh number with pulverizer and be more than 100 mesh；
Take Cordyceps militaris of the water content not higher than 10% to be crushed to particle diameter mesh number with pulverizer and be more than 100 mesh；
The preferable cordyceps sinensis for taking water content to be not higher than 8% is crushed to particle diameter mesh number with pulverizer and is more than 100 mesh；Take and contain
Cordyceps militaris of the water not higher than 8% is crushed to particle diameter mesh number with pulverizer and is more than 100 mesh；
Preferable cordyceps sinensis water content is not higher than 5%, and Cordyceps militaris water is not higher than 5%.
The cordyceps sinensis powder of proportional quantity and Cordyceps militaris powder are uniformly mixed；
Direct tablet compressing is carried out according to demand with tablet press machine, per sheet weight about 0.2-0.6g.
On the other hand, cordyceps sinensis lozenge of the present invention can also use following preparation method：
A, the water content of proportioning is taken to be used after being mixed not higher than 10% cordyceps sinensis with Cordyceps militaris of the water content not higher than 10%
Pulverizer crushes；
B, tabletting.
In order to confirm that the cordyceps sinensis lozenge that present invention proportioning obtains has excellent effect, when main test mouth containing acts on
Between, the appearance to tablet, uniformity of dosage units have carried out integrated survey to the present invention at the same time, and the good of appearance is determined according to following standard
It is bad：Appearance is mainly considered from surface smoothness, broken brittleness etc.：It is excellent to be ++++, it is good to be +++, generally ++, difference for+.
By applying the present invention, the Cordyceps sinensis buccal tablets any surface finish being prepared, good moldability, rigidity is strong, is acted in mouth
Time is grown, and absorbs fully, and in good taste, due to the high adhesive of no any sugar content of addition, to avoiding because of long-term mistake
The people for eating sugar, causing human body to get fat and induce the diseases such as hypertension, diabetes, cardiovascular disease, nephrosis of amount have well
Auxiliary curative effect, its health care and therapeutic effect are more notable.
Embodiment
Technical solution of the present invention is described in detail with reference to specific embodiment, but specific embodiment is simultaneously
It is not the limitation to present invention.
(the proportioning 10 of embodiment 1：1)
Take the Cordyceps militaris 10g pulverizers of cordyceps sinensis 1000g of the water content not higher than 8% and water content not higher than 8%
It is crushed to particle diameter and is less than 100 mesh, directly carries out tabletting with tablet press machine, pressure is controlled in 4.5kg-10kg, and every weighs about 0.25g.
Hardness：6.7kg
Appearance：++++
(the proportioning 3 of embodiment 2：1)
Take cordyceps sinensis 750g of the water content not higher than 8% to be crushed to particle diameter with pulverizer and be less than 100 mesh, take water content not
Cordyceps militaris 250g higher than 8% is crushed to particle diameter with pulverizer and is less than 100 mesh, after mixing, is directly pressed with tablet press machine
Piece, pressure are controlled in 4.5kg-10kg, and every weighs about 0.25g.
Hardness：7.7kg
Appearance：++++
(the proportioning 5 of embodiment 3：1)
Take cordyceps sinensis 1000g of the water content not higher than 3% to be crushed to particle diameter with pulverizer and be less than 100 mesh, take water content
Cordyceps militaris 200g not higher than 3% is crushed to particle diameter with pulverizer and is less than 100 mesh, after mixing, is directly carried out with tablet press machine
Tabletting, pressure are controlled in 4.5kg-10kg, and every weighs about 0.25g.
Hardness：7.1kg
Appearance：++++
(the proportioning 3 of embodiment 4：1)
Take cordyceps sinensis 750g of the water content not higher than 10% to be crushed to particle diameter with pulverizer and be less than 100 mesh, crush full mistake
Journey is cooled down with coolant of the temperature less than 8 DEG C, takes Cordyceps militaris 250g of the water content not higher than 10% to be crushed to particle diameter with pulverizer
Less than 100 mesh, crush overall process and cooled down with coolant of the temperature less than 8 DEG C, it is ensured that the release of active ingredient and bioactivity
Stablize.
Cordyceps militaris Ultramicro-powder is mixed for 10 times with the acid water that pH value is 3 by solid-liquid ratio (g/mL), extracts 40min
Afterwards, centrifuge, the neutral water for taking precipitation and pH value to be 7 is mixed again by solid-liquid ratio 10, after extracting 40min, centrifugation, take precipitation and
The alkaline water that pH value is 12 is mixed again by solid-liquid ratio 10, and after extracting 40min, centrifugation, merges centrifugation three times and obtain supernatant,
20-30 times concentrates, and obtains cordycepin extracting solution.
Cordyceps militaris Ultramicro-powder is mixed for 10 times with the acid water that pH value is 5 by solid-liquid ratio (g/mL), extracts 40min
Afterwards, centrifuge, take precipitation to be mixed again by solid-liquid ratio 10 with the 0.1mol/L sodium phosphate buffers that pH value is 7, extract 40min
Afterwards, centrifuge, take precipitation to be mixed again by solid-liquid ratio 10 with the alkaline water that pH value is 8.5, after extracting 40min, centrifugation, merges three
Secondary to centrifuge obtained supernatant, 20-30 times concentrates, and obtains the adenosine extracting solution of content more than 0.4%.
By the cordycepin extracting solution being prepared, adenosine extracting solution, 95% edible alcohol according to 1:1:4 volume ratio mixing
Uniformly, softening agent is made.According to cordyceps sinensis：Cordyceps militaris：Cordycepin：Adenosine=3:1:0.3:Softening agent is measured after 0.3 conversion,
It is slowly added to it equably with cordyceps sinensis and Cordyceps militaris micro mist, is stirred continuously at the same time, is polymerize cordyceps sinensis in the form of spraying
It is agglomerating, particle of the same size is formed, at once pours into the semi-finished product mixed in wet granulator, selects the sieve of 24 mesh to shake
Pendulum granulation.Cordyceps sinensis particle is collected with the stainless steel disc after disinfection, slight concussion spreads out its uniform monolayers, prevents from luming, afterwards
It is put into baking oven and continues to be dried to moisture less than 5% for 37 DEG C, and except remaining alcohol in degranulation；Drying is placed on granulation
Whole grain obtains cordyceps sinensis particle in machine.The cordyceps sinensis particle prepared is added in tablet press machine and carries out tabletting, pressure is controlled in 4.5kg-
10kg, every weighs about 0.25g.
Hardness：4.2kg
Appearance：+++
(the proportioning 3 of embodiment 5：1)
Take cordyceps sinensis 750g of the water content not higher than 10% to be crushed to particle diameter with pulverizer and be less than 100 mesh, crush full mistake
Journey is cooled down with coolant of the temperature less than 8 DEG C, takes Cordyceps militaris 250g of the water content not higher than 10% to be crushed to particle diameter with pulverizer
Less than 100 mesh, crush overall process and cooled down with coolant of the temperature less than 8 DEG C, it is ensured that the release of active ingredient and bioactivity
Stablize.
Cordyceps militaris Ultramicro-powder is mixed for 10 times with the acid water that pH value is 3 by solid-liquid ratio (g/mL), extracts 40min
Afterwards, centrifuge, the neutral water for taking precipitation and pH value to be 7 is mixed again by solid-liquid ratio 10, after extracting 40min, centrifugation, take precipitation and
The alkaline water that pH value is 12 is mixed again by solid-liquid ratio 10, and after extracting 40min, centrifugation, merges centrifugation three times and obtain supernatant,
20-30 times concentrates, and obtains cordycepin extracting solution.
By the cordycepin extracting solution being prepared, 95% edible alcohol according to 1：3 volume ratio is uniformly mixed, and softening is made
Agent.According to cordyceps sinensis：Cordyceps militaris：Cordycepin=3:1:Softening agent is measured after 0.6 conversion, is slowly added to make in the form of spraying
It equably with cordyceps sinensis and Cordyceps militaris micro mist, is stirred continuously at the same time, makes cordyceps sinensis polymerization agglomerating, forms of the same size
Grain, at once pours into the semi-finished product mixed in wet granulator, selects the sieve oscillating granulation of 24 mesh.With stainless after disinfection
Steel disk collects cordyceps sinensis particle, and slight concussion spreads out its uniform monolayers, prevents from luming, be put into afterwards in baking oven and continue to dry for 37 DEG C
It is less than 5% to moisture, and except remaining alcohol in degranulation；Drying is placed on whole grain in granulator and obtains cordyceps sinensis particle.
The cordyceps sinensis particle prepared is added in tablet press machine and carries out tabletting, pressure is controlled in 4.5kg-10kg, and every weighs about 0.25g.Firmly
Degree：4.1kg
Appearance：+++
Table 1 is that the cordyceps sinensis buccal tablet obtained using different formulations, every weighs about using the identical method of embodiment 2
0.25g。
Table 1
Table 2 is the tablet appearance that embodiment 1-16 is prepared, and disintegration time, sucks time, technological feasibility result.
Table 2
Table 3 is the indicator difference that buccal tablet made from 1-16 of the embodiment of the present invention is observed.
Table 3
The Cordyceps sinensis buccal tablets appearance that embodiment 1-3 is prepared it can be seen from table 1 to table 3, in good taste, preparation process letter
Monostable fixed, for disintegration time in 14-22 minutes, the mouth containing time is unilateral without obvious yin macules, tabletting time slice weight in 25-36 minutes
Stablize, RSD values are less than 4%, and tablet weight variation is smaller, and tablet has preferable uniformity of dosage units, and indices meet regulation.
Embodiment 17：Influence of the cordyceps sinensis lozenge to immune function of mice
C57BL/6J mouse, male, 6-8 week old, weight 18-22g, raises and is ground in Zhejiang University of Traditional Chinese Medicine's zoopery
Study carefully center, recommend dose [1.2g. (60kg) daily by normal adult-1] 10 times of setting dosages, be 200mg.kg-1, separately
If Normal group (gives physiological saline), every group of 6 mouse, adaptability is raised 3 days, is weighed, is grouped by random digits table,
Following experiments are carried out respectively.1. the influence that mouse cell is immunized in cordyceps sinensis lozenge, includes the mice spleen lymph of ConA inductions
Cell Proliferation and the mouse delayed allergy experiment of DNFB inductions；To add the absorbance in ConA holes (A) value and be not added with ConA
A values represent mice spleen lymphocytes proliferation ability, auris dextra and left ear quality differential DTH；2. cordyceps sinensis lozenge is to Mice Body
The influence that liquid is immunized：Antibody-producting cell and serum hemolysin are detected, mouse antibodies cellulation level is represented with each hole A values,
Mice serum antibody level is represented by formula calculating antibody product；3. cordyceps sinensis lozenge is to mouse monokaryon-macrophage function
Influence：Mouse carbonic clearance and peritoneal macrophage phagocytosis fluorescent microsphere experiment；Phagocytic index is calculated by formula, represents mouse carbon
Ability is cleaned up, Turnover of Mouse Peritoneal Macrophages phagocytic activity is represented with phagocytic percentage.4. cordyceps sinensis lozenge is to NK cells in mice
The influence of activity, measures each hole A values, and each NK cells in mice activity is calculated by formula.Each embodiment cordyceps sinensis is weighed respectively to contain
10.0mg.mL is made in piece-1Suspension, gives corresponding dosage gavage, 0.4mL. (20g)-1, Normal group gives identical capacity
Physiological saline, 1 time a day, totally 30 days.Reference《Health food is examined and assessment technique specification》(2003 editions) and《Pharmacological evaluation side
The science of law》.Using the mice spleen lymphocytes proliferation ability of CCK8 methods detection ConA inductions, ear swelling method detection DNFB induces small
Mouse delayed allergy, Quantitative Haemolytic spectrophotometry mouse antibodies cellulation number, Hemagglutination mice serum
Hemolysin level, angular vein injection detection mouse carbonic clearance ability, by document (Zhang Jianlou et al., animal medicine progress,
2011,32 (3)：86-90).Turnover of Mouse Peritoneal Macrophages first is marked with F4/80, flow cytometer measure phagocytosis fluorescent microsphere
Number of macrophages, determination of lactate dehydrogenase NK cytoactives.Using 19.0 editions software data processings of SPSS, experimental data with
Mean ± standard deviation (x ± s) represents that mean compares between two groups is examined using independent sample T, and multigroup mean compares using Dan Yin
Plain variance analysis (One-Way ANOVA).With P<0.05 is statistically significant for difference.
Table 4：Cordyceps sinensis lozenge is to mouse cell immune function result of the test
Result of the test shows, compared with Normal group, the cordyceps sinensis lozenge that each embodiment is prepared can improve
The mice spleen lymphocytes proliferation ability (* P ＜ 0.01) of ConA inductions, the cordyceps sinensis that wherein embodiment 1-3 is prepared contains
Piece can be obviously improved mouse delayed allergy (compared with Normal group, P ＜ 0.01), unexpected and embodiment
4 and 5 with the addition of cordycepin extracting solution, and cordycepin extracting solution and adenosine extracting solution result of the test are suitable.
Table 5：Cordyceps sinensis lozenge is to mouse humoral immune function test result
Result of the test shows, compared with Normal group, the cordyceps sinensis lozenge that each embodiment is prepared can improve
Mouse antibodies generation is horizontal (* P ＜ 0.01), and compared with Normal group, the lozenge that embodiment 1-3 is prepared can be carried significantly
High mice serum hemolysin level, it is unexpected to the addition of cordycepin extracting solution with embodiment 4 and 5, cordycepin extracting solution and
Adenosine extracting solution result of the test is suitable.
Table 6：Cordyceps sinensis lozenge is to mouse monokaryon-macrophage function result of the test
Result of the test shows, compared with Normal group, the cordyceps sinensis lozenge that each embodiment is prepared can improve
Mouse carbonic clearance level (* P ＜ 0.01).And the ability of Turnover of Mouse Peritoneal Macrophages phagocytosis fluorescent microsphere significantly improves, real
The lozenge that a 1-3 is prepared is applied to be obviously improved.
Table 7：Cordyceps sinensis lozenge is to NK cells in mice activity test result
Result of the test shows, compared with Normal group, the cordyceps sinensis lozenge that each embodiment is prepared can improve
NK cells in mice activity (* P ＜ 0.01), the lozenge that embodiment 1-3 is prepared is obviously improved.
Claims (10)
- A kind of 1. cordyceps sinensis lozenge, by cordyceps sinensis, Cordyceps militaris composition.
- 2. cordyceps sinensis lozenge according to claim 1, the cordyceps sinensis quality accounting 45%-95%, the pupa worm Herbaceous stem amount accounting 5%-55%.
- 3. cordyceps sinensis lozenge according to claim 1, the cordyceps sinensis quality accounting 50%-95%, the pupa worm Herbaceous stem amount accounting 5%-50%.
- 4. cordyceps sinensis lozenge according to claim 1, the Cordyceps militaris and cordyceps sinensis mass ratio 1：(3-5).
- 5. a kind of preparation method of the cordyceps sinensis lozenge described in any rights of claim 1-4, including step：A, the cordyceps sinensis of proportioning is taken to be crushed after being mixed with Cordyceps militaris with pulverizer；B, tabletting.
- 6. preparation method according to claim 5, the cordyceps sinensis water content is less than 10%.
- 7. preparation method according to claim 5, the Cordyceps militaris water content is less than 10%.
- 8. preparation method according to claim 5, the cordyceps sinensis is crushed to particle diameter mesh number and is more than 100 mesh.
- 9. preparation method according to claim 5, the Cordyceps militaris is crushed to particle diameter mesh number and is more than 100 mesh.
- 10. preparation method according to claim 5, the lozenge that the tabletting obtains is per sheet weight 0.2-0.6g.
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