CN107981967A - A kind of cold compress application for carrying silicate particulate - Google Patents
A kind of cold compress application for carrying silicate particulate Download PDFInfo
- Publication number
- CN107981967A CN107981967A CN201610947552.2A CN201610947552A CN107981967A CN 107981967 A CN107981967 A CN 107981967A CN 201610947552 A CN201610947552 A CN 201610947552A CN 107981967 A CN107981967 A CN 107981967A
- Authority
- CN
- China
- Prior art keywords
- cold compress
- particulate
- silicate
- silicate particulate
- cold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 title claims abstract description 36
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 27
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 27
- 239000002245 particle Substances 0.000 claims abstract description 24
- 239000002562 thickening agent Substances 0.000 claims abstract description 9
- 238000009826 distribution Methods 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 13
- 229910052613 tourmaline Inorganic materials 0.000 claims description 12
- 239000011032 tourmaline Substances 0.000 claims description 12
- 229940070527 tourmaline Drugs 0.000 claims description 12
- 239000000454 talc Substances 0.000 claims description 9
- 229910052623 talc Inorganic materials 0.000 claims description 9
- 235000012222 talc Nutrition 0.000 claims description 9
- 238000007710 freezing Methods 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000010445 mica Substances 0.000 claims description 5
- 229910052618 mica group Inorganic materials 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 4
- 239000010977 jade Substances 0.000 claims description 4
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 4
- 229910052845 zircon Inorganic materials 0.000 claims description 4
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 238000010257 thawing Methods 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 229920001661 Chitosan Polymers 0.000 claims description 2
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 229940045110 chitosan Drugs 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 229960005188 collagen Drugs 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 239000012876 carrier material Substances 0.000 claims 2
- 239000000470 constituent Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 12
- 238000000034 method Methods 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 6
- 238000009413 insulation Methods 0.000 abstract description 4
- 238000012546 transfer Methods 0.000 abstract description 3
- 239000000969 carrier Substances 0.000 abstract description 2
- 238000004132 cross linking Methods 0.000 abstract description 2
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000008827 biological function Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000013049 sediment Substances 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000004062 sedimentation Methods 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 230000004087 circulation Effects 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 150000002085 enols Chemical class 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229920000433 Lyocell Polymers 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000009938 salting Methods 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 229910052604 silicate mineral Inorganic materials 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011232 storage material Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- TUGDLVFMIQZYPA-UHFFFAOYSA-N tetracopper;tetrazinc Chemical compound [Cu+2].[Cu+2].[Cu+2].[Cu+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2] TUGDLVFMIQZYPA-UHFFFAOYSA-N 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/0241—Apparatus for the preparation of hot packs, hot compresses, cooling pads, e.g. heaters or refrigerators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
- A61F2007/0204—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing clay, mud, fango, sand, kaolin clay, volcanic or other inorganic granular solids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
- A61F2007/0206—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor containing organic solids or fibres
- A61F2007/0209—Synthetics, e.g. plastics
- A61F2007/0214—Polymers, e.g. water absorbing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0225—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof
- A61F2007/0226—Compresses or poultices for effecting heating or cooling connected to the body or a part thereof adhesive, self-sticking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0282—Compresses or poultices for effecting heating or cooling for particular medical treatments or effects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0295—Compresses or poultices for effecting heating or cooling for heating or cooling or use at more than one temperature
Abstract
Carry silicate particulate cold compress application and belong to medical instruments field, be related to a kind of cold appliance.The present invention is physical crosslinking using polyvinyl alcohol in multigelation to be combined with solid particles sediment process, there is provided the cold compress with controlled concentration gradient silicate particulate applies.It is not only to make full use of its biological effect to provide condition, and gradient distribution plays heat transfer cushioning effect, it can be achieved that more preferably cold compress sensitivity and longer cold insulation time.Fixing particulate by polymer grid makes system more stablize, and is easy to remove after use.Small size, the porous use for waiting silicate particulate, provides the foundation for multifunction.Its application range has been expanded in the use of different carriers and thickener and the adjustment in application pattern, collocation type of service etc. carried out according to use demand.The present invention provides comfort and convenient, and contact is good, holds the cold compress dressing of cool time length and a variety of biological functions of tool, suitable for various medical cold compress occasions.
Description
Technical field
The present invention relates to a kind of medical instrument, and in particular to a kind of cold compress application for carrying silicate particulate, during this is applied
Particulate has concentration gradient, and while cold compress effect is effectively adjusted, the particulate of these gradient concentrations can provide the work(of uniqueness
Energy.
Background technology
Cold compress is one of common physical therapy modalities.By reducing local tissue temperature, the local blood of contraction can be reached
Pipe, analgesia, mitigates the multi-effects such as inflammatory swelling.For illness such as acute injury, local inflammations, cold compress is widely used.Perhaps
More cool storage mediums are used for the structure of cold compress medical instrument, including low-temperature receiver conduction, ice cube/ice crystal, salting liquid, organic phase change material
And Macromolecule colloid etc..But the apparatus built using these media merely still has some shortcomings, including body tissue
Contact surface local temperature is uncontrollable, and the cold insulation time is short, and body contact sensitivity is poor, shadow of the external low-temperature receiver to security and ease for use
Ring etc..The exploitation of Novel cold-storage agent solves the problems, such as these to a certain extent with application, such as the medical poly- second of excellent in design
Enol（PVA）Gel etc., but it is directly relatively low using cold compress temperature, and it is still limited to hold cold energy power under body temperature, one
A little require emphasis more is limited using the applications of comfort and cold insulation time, and the domain specific application such as skin with the surface of a wound is cold
The function of some particular demands can not be provided in applying.
Because of a variety of special performances that it has, application of the silicate particulate in biomedical material more receives pass recently
Note.Silicate is one of mineral that content is most abundant in the earth's crust, including the multi mineral such as jade, tourmaline, zircon, mica, talcum
Substantially belong to silicate.Some novel silicates built based on modern science and technology, such as bio-vitric, even more one
Its advantage of a little important clinical practice saliencies.Recent research discloses these silicate material particulates in skin repair and U.S.
May have the function of in terms of holding beauty treatment a variety of positive.Such as it is beautiful, jade and tourmaline may have trace element release, bear
Ion and Electromagnetic Environmental Effect；Zircon, mica and talcum etc. can provide different physical stimulations and improve local organization microenvironment；
Bio-vitric shows significant antibacterial and promotes wound tissue's repairing effect etc..The above effect is that many clinics are cold
Apply what occasion needed, but these particulate cold-storage abilities and capacity of heat transmission are poor, it is difficult to directly as cold compress medium.If it can incite somebody to action
These particulates are combined with suitable cold compress medium, it would be possible to more effectively meet clinical demand.
It is one of possible combined use method that directly silicate particulate, which is added cool storage medium and is uniformly mixed, but is had
The shortcomings that some are obvious.In the case where being not added with thickener, excipient or other carriers, silicate particulate can have faster certainly
So sedimentation, causes unexpected local concentration change occur, the control to product quality and preparation process brings difficulty.In particulate
During with specific function, tissue contact surface requires certain concentration, and since the influence of sedimentation, simple mixing may be on the contrary
It is difficult to control.In addition, if the particulate of tissue contact surface sedimentation is excessive, it would be possible to causes to apply temperature herein and is asked with intensity
Topic.Also, after dressing local temperature rises under body temperature effect, the change of physical property may cause these particulates unexpected
Disengage, be built-up in the trouble that some subsequent treatments are brought on cold compress position.I.e. use can help silicate particulate in application
The carrier being evenly distributed as far as possible, it is non-to some with higher cost and only in the material of contact body part competence exertion effect
The particle of tissue contact surface is actually wasted.In fact, since the heat transfer of silicate granules postpones, as can in collocation cold-storage
Ensure certain distribution in contact surface direction during medium, for improving contact surface temperature, extend the cold insulation time, ensure particulate function etc.
Positive effect is respectively provided with, this is difficult uniformly to mix, and the mode of natural cold-storage reaches, and needs innovative means.
The content of the invention
To solve the prior art applied to deficiency when carrying silicate particulate cold compress dressing, the design of the invention
Contain mass concentration in dressing（w/v）For the polyvinyl alcohol of 0.5-15%（PVA）And the silicate particulate of 0.1-32%, and pass through
The orderly sedimentation of silicate particulate is combined with the physical crosslinking of polyvinyl alcohol, ensures dressing substrate face to tissue contact surface
Particulate has controllable concentration gradient.The present invention is mainly prepared by the following technical solutions.By the poly- second of above content
Enol and the uniform mixed liquor of silicate particulate are carried on carrier, with not higher than -10 DEG C freezings at least 2 it is small when, with not less than 20
DEG C thaw, upset, repeats the circulation of above step at least three.In this technical solution, PVA repeatedly freeze and thaw cycles
In can gradually form cross-linked network, the sedimentation of the formation of these networks to wherein silicate particulate gradually forms limitation, and
Freeze with the switching process in thaw cycles, temporary transient uncurbed particulate is settled to opposite direction, avoid too fast excessive single
Direction particle aggregation.Finally, after PVA cross-mesheds are formed completely, on the one hand particulate is limited among grid, meanwhile,
Particulate can provide the network of PVA certain support because of its rigid nature.PVA that the technical program is provided with
Under the conditions of silicate particulate content, it is aided with other factors such as carrier and selects, particle properties control and thickener adjustment etc., can control
Any particle concentration gradient in one direction of dressing processed.Due to the effective control and maintenance of sinking speed, overall density gradient can
To accomplish more balanced and preferably be ensured in quality control and process aspect.The presence of PVA cross-mesheds with to micro-
Grain progressively limitation, it is ensured that high concentration direction particulate is unlikely to excessive, and even if with tissue contact after gradually thaw, particulate
Also be not easy it is unordered from system disengage, this both ensure that the action time of functional particle, to avoiding high cost particulate from losing
Lose equally has positive effect with wasting.Also, the cold compress dressing built in this way, have the silicate particulate of concentration gradient with
PVA grids in fact play the role of certain heat transfer gradient buffer, and when tissue contact surface is high concentration, contact surface is lasting
Operative temperature rises, and user experiences lifting, and under the premise of overall cold-storage ability does not have big change, always hold cool time
Effective extension is obtained.
The technical program, which can accomplish to provide the silicate particulate infall process of various sizes and pattern, effectively to be controlled, especially
It is the less particulate of scale.Have confirmed there is the particulate of small-size effect, in biomedical applications in research before
There can be many special nature and function.Small size particulate sinking speed is slower, this was conducive in natural subsidence bar originally
Concentration gradient is formed under part, still, due to the building-up effect under the influence of many factors, particle may under the conditions of simple be suspended
Assemble agglomerating, destroy system stability and simultaneously change application bulk property.Too small size particles residual is also easy after tissue contact
Cause a problem of security concern.And the network that the PVA in the technical program is gradually formed, can effectively it limit
The aggregation of these particulates, guarantee system stability, is also easy to remove using the particulate for having grid to limit after completing.Using this
Under the ratio that scheme is supplied to, particle size is less than 180 microns can also be by effectively scattered and limitation.Equally, except small
Scale effect, the application of loose structure particulate powder equally benefit from the scattered and limitation of PVA in system.It is particles modified process it is past
Other materials are carried toward the surface nature or offer for being conceived to enhancing particulate to exercise specific function, the scattered and limit of PVA grids
System had both avoided these aggregations for being modified particulate, excessive sedimentation, and was capable of providing controllable carrier concn and ensures carrying object
Suitable release conditions.Still there is the special case of concentration gradient in the case, as tissue contact surface only needs the carrying object of low concentration
When discharging, and ensureing its sustained release time again, the dressing body that reverse tissue contact surface is low concentration particulate can be built
System.Even, under particular requirement, subregion density of particle gradient is forward direction, and tissue contact surface direction is high density at this time,
Subregion density of particle gradient is negative sense, and basal surface direction can also build for highdensity application at this time.Finally, as above institute
State, silicate mineral has many types, its a variety of particulate may have the function of a variety of, and this is slightly
Grain can be used in mixed way to reach specific purpose by rights.The particle type that the technical program has verified that includes
Jade, tourmaline, zircon, mica, talcum, bio-vitric and its mixture etc., but do not exclude the use of other silicate particulates.
PVA can gradually form grid and silicate particulate is formed and support in the technical program, but use physics mode
Form that the process of grid is slower, reach the fine concentration more complicated technique of control needs and more costs, and chemical crosslinking side
The use of formula may bring unnecessary security risks.In contrast, appropriate carrier and thickener excipient selection be compared with
For easy optimization method.The common carrier selection of application class product is flexible non-woven fabrics material, when in this way,
Application can be easily bonded with expected using position, use feeling also comparative comfort.But due in this programme with PVA nets
The silicate particulate of lattice limitation exists, especially a certain when being required in particular demands during release function when particulate mainly plays carrying
When particle concentration is larger on direction, due to the rigid nature of particulate in itself, flexible carrier is difficult to effectively rise in some cases
Limited to auxiliary, the effect of support.In this case, the use of Rigid Porous carrier is probably more useful.As for thickener
Selection, the material with certain sticky property of bio-compatible can be selected, but optimal scheme is to enable these thickeners
Equally have the function of it is certain, mutually to promote with expected silicate particulate effect.The increasing used has been attempted in research before
Thick dose includes Sodium Hyaluronate, collagen, sodium alginate, chitosan and its mixture etc., but the technical program is not limiting as other
The use of material.Finally, the technical program expection will can be used in the cold compress dressing at each position of body, therefore a variety of shapes
Shape is necessary in the form of adapting to intended application position, especially when having used special building mode, such as rigid carrier
Or during more viscous thickener.
To make the feature and technology contents that are further understood that the present invention, drawings and embodiments of the present invention are referred to, but
Institute's drawings and the embodiments citing is only for reference with illustrating, is not that the present invention is any limitation as.
Brief description of the drawings
Fig. 1 is vertical section structure chart of the present invention；
In figure, 1- carries the cold compress application of silicate particulate；2-PVA cross-mesheds；3- is distributed in application with concentration gradient
Silicate particulate；4- basal surfaces；5- tissue contact surfaces.
Embodiment
The present invention will be further described with reference to the accompanying drawings and examples.
Embodiment 1：
As shown in Figure 1, the cold compress application of beautiful powder particulate is carried, wherein containing mass concentration（w/v）For 8.0% polyvinyl alcohol, 1.0%
Beautiful powder particulate, the beautiful powder particulate of its basal surface to tissue contact surface has concentration gradient and its basal surface is low concentration, group
It is high concentration to knit contact surface.Its preparation method includes preparing uniformly mixed polyvinyl alcohol with granularity as 100 microns using pure water
The beautiful powder particulate mixed liquor of left and right, is carried on the bulky nonwoven cloth base material that pre-cut is standard rectangular, 6 small with -20 DEG C of freezings
When, with 37 DEG C of 6 hours of defrosting, upset, repeats 3 circulations of above step.The cold compress dressing obtained is used for skin after laser operation
The surface cold compress of skin.
Embodiment 2：
The cold compress application of superoxide dismutase tourmaline particles is carried, wherein containing mass concentration（w/v）For 2.0% polyethylene
Alcohol, the 2.0% porous tourmaline particles of pretreatment, the tourmaline particles of its basal surface to tissue contact surface have concentration gradient simultaneously
And its basal surface is high concentration, tissue contact surface is low concentration.Its preparation method includes
Carried in the tourmaline small porous particle of 150 microns and contain copper-zinc superoxide dismutase（SOD）, it is uniform with polyvinyl alcohol
Mixed liquor is carried on pre-prepared porous polyethylene（PE）On carrier, with -20 DEG C of 12 hours of freezing, with the room not less than 20 DEG C
Temperature is thawed 12 hours, upset, repeats 5 circulations of above step.The surface that the cold compress dressing obtained is used for sensitive skin is cold
Applying treatment.
Embodiment 3：
The cold compress application of tourmaline particulate is carried, wherein containing mass concentration（w/v）For 1.0% polyvinyl alcohol, 0.1% tourmaline particulate
And 0.5% Sodium Hyaluronate, the tourmaline particulate of its basal surface to tissue contact surface has concentration gradient and its basal surface is low
Concentration, tissue contact surface are high concentration.Its preparation method include using pure water prepare mixed uniformly polyvinyl alcohol, granularity as
The tourmaline particulate and Sodium Hyaluronate of 100 microns, are carried on the Tencel fiber base materials that pre-cut is eye shape,
With -80 DEG C of 3 hours of freezing, with 37 DEG C of 12 hours of defrosting, upset, repeats 8 circulations of above step.The cold compress obtained is applied
Material is used for eye cold compress.
Embodiment 4：
The cold compress application of mixing talcum particulate and bio-vitric particulate is carried, wherein talcum particle areas contains mass concentration（w/v）
For 2.0% polyvinyl alcohol, 5.0% talcum particulate, bio-vitric particle areas contains mass concentration（w/v）For 2.0% poly- second
Enol, 1.0% bio-vitric particulate.Its preparation method is：Mixed liquor is prepared respectively, is carried on non-woven fabrics base material, and by -20
DEG C 12 hours of freezing, with 12 hours of thaw at RT, upset, the modes for repeating 3 circulations of above step are built, and are being obtained
The base material for carrying bio-vitric particulate after the cold compress application of tool concentration gradient is overturn, and is spliced with talcum particulate pickup zone
After use.Talcum has opposite concentration gradient with mica particles in this cold compress application, and it is notable that it organizes contact sense of touch to have
Difference, be more suitable for the position that there are obvious surface property differences to part, the cold compress in area of such as forming a scab, and bio-vitric is micro-
Grain had both reduced its irritation in the low concentration of contact surface and the high concentration of basal surface, in turn ensure that the antibacterial effect of continuation.
The citing of embodiment described above, the simply specific embodiment of the invention, those skilled in the art is in this hair
The usual variations and alternatives carried out in the range of bright technical solution should all include within the scope of the present invention.
Claims (10)
- A kind of 1. cold compress application for carrying silicate particulate, it is characterized in that including mass concentration in constituent（w/v）For 0.5-15% Polyvinyl alcohol, the silicate particulate of 0.1-32%, and the particle concentration of its basal surface to tissue contact surface has gradient.
- 2. cold compress application according to claim 1, it is characterised in that preparation method includes polyvinyl alcohol and silicate particulate Uniform mixed liquor is carried on carrier, with not higher than -10 DEG C freezings at least 2 it is small when, with not less than 20 DEG C defrostings, overturn, repeat Above step at least three circulates.
- 3. cold compress application according to claim 1, it is characterised in that the granularity of silicate particulate is less than 180 microns.
- 4. cold compress application according to claim 1, it is characterised in that silicate particulate is loose structure.
- 5. cold compress application according to claim 1, it is characterised in that subregion density of particle gradient is forward direction, at this time group It is high density to knit contact surface direction, and subregion density of particle gradient is negative sense, and basal surface direction is highdensity at this time Application.
- 6. cold compress application according to claim 1, it is characterised in that silicate particulate is the mixture of Multiple components, these Component includes but not limited to：Jade, tourmaline, zircon, mica, talcum, bio-vitric.
- 7. cold compress application according to claim 1, it is characterised in that the carrier material of load polyvinyl alcohol and silicate particulate Expect for flexible nonwoven material.
- 8. cold compress application according to claim 1, it is characterised in that the carrier material of load polyvinyl alcohol and silicate particulate Expect for Rigid Porous material.
- 9. cold compress application according to claim 1, it is characterised in that thickener is added to adjust the concentration distribution of particulate, this A little thickeners include but not limited to：Sodium Hyaluronate, collagen, sodium alginate, chitosan.
- 10. cold compress according to claim 1 application, it is characterised in that be processed into different application shapes with suitable body not With the use at position.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610947552.2A CN107981967A (en) | 2016-10-26 | 2016-10-26 | A kind of cold compress application for carrying silicate particulate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610947552.2A CN107981967A (en) | 2016-10-26 | 2016-10-26 | A kind of cold compress application for carrying silicate particulate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107981967A true CN107981967A (en) | 2018-05-04 |
Family
ID=62029103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610947552.2A Pending CN107981967A (en) | 2016-10-26 | 2016-10-26 | A kind of cold compress application for carrying silicate particulate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107981967A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108948392A (en) * | 2018-06-29 | 2018-12-07 | 广东工业大学 | A method of improving polyvinyl alcohol hydrogel mechanical property |
| CN112336907A (en) * | 2020-10-23 | 2021-02-09 | 紫水晶(海南)再生医学科技有限公司 | Bioactive glass material for hemostasis and repair and preparation method thereof |
Citations (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62250940A (en) * | 1986-04-23 | 1987-10-31 | Agency Of Ind Science & Technol | Temperature responsive porous gel and its preparation |
| EP0309278A2 (en) * | 1987-09-25 | 1989-03-29 | Riker Laboratories, Inc. | Use of sorbent sheet material as evaporative coolants |
| JPH06296675A (en) * | 1993-04-16 | 1994-10-25 | Suzuki Yushi Kogyo Kk | Adhesive plaster to be used for human body |
| JPH10328224A (en) * | 1997-06-04 | 1998-12-15 | Nitto Denko Corp | Porous wrapping material and its storing bag |
| JP2001081431A (en) * | 1999-09-16 | 2001-03-27 | Asahi Kasei Corp | Adhesive for inner lining and bondable inner lining |
| JP2002345875A (en) * | 2001-05-25 | 2002-12-03 | Nitto Denko Corp | Exothermic body |
| US20030190336A1 (en) * | 2002-03-18 | 2003-10-09 | Adams Christine Helga | Personal care compositions comprising solid particles enterapped in a gel network |
| CN1496395A (en) * | 2002-05-20 | 2004-05-12 | 麦考尔株式会社 | Exothermic composition and exothermic body |
| TW200704434A (en) * | 2005-04-18 | 2007-02-01 | Showa Denko Kk | Water-containing gel form and production method thereof |
| RU70792U1 (en) * | 2007-03-20 | 2008-02-20 | Игорь Иванович Пашкин | MEDICAL APPLICATOR |
| CN101325932A (en) * | 2005-12-15 | 2008-12-17 | 金伯利-克拉克环球有限公司 | Therapeutic kit employing a thermal insert |
| JP2009024086A (en) * | 2007-07-19 | 2009-02-05 | Harima Chem Inc | Method of manufacturing supported type solid heat storing material |
| CN101939230A (en) * | 2008-02-06 | 2011-01-05 | 日东来福泰株式会社 | Be used to seal porous membrane, heat-sealing bag member of formation and disposable body warmer with the bag member of formation |
| CN202950817U (en) * | 2012-11-07 | 2013-05-29 | 浙江三赢医疗器械有限公司 | Inorganic mineral physiotherapy bag |
| JP2014054485A (en) * | 2012-09-14 | 2014-03-27 | Nitto Lifetech Kk | Adhesive member for skin stick-on body warmer and skin stick-on body warmer |
| JP2014074146A (en) * | 2012-10-05 | 2014-04-24 | Double Scope Kk | Porous membrane and manufacturing method thereof |
| CN104394814A (en) * | 2012-06-29 | 2015-03-04 | 桐灰化学株式会社 | Heat generation tool |
| CN105255453A (en) * | 2015-11-18 | 2016-01-20 | 北京恒天易德生物科技有限公司 | Novel cooling storage agent and preparation method thereof |
| CN205054577U (en) * | 2015-10-12 | 2016-03-02 | 天津市山佳医药科技有限公司 | Disconnect -type spontaneous heating eye -shade |
| CN106414571A (en) * | 2014-06-03 | 2017-02-15 | 三菱树脂株式会社 | Porous film and storage bag |
-
2016
- 2016-10-26 CN CN201610947552.2A patent/CN107981967A/en active Pending
Patent Citations (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62250940A (en) * | 1986-04-23 | 1987-10-31 | Agency Of Ind Science & Technol | Temperature responsive porous gel and its preparation |
| EP0309278A2 (en) * | 1987-09-25 | 1989-03-29 | Riker Laboratories, Inc. | Use of sorbent sheet material as evaporative coolants |
| JPH06296675A (en) * | 1993-04-16 | 1994-10-25 | Suzuki Yushi Kogyo Kk | Adhesive plaster to be used for human body |
| JPH10328224A (en) * | 1997-06-04 | 1998-12-15 | Nitto Denko Corp | Porous wrapping material and its storing bag |
| JP2001081431A (en) * | 1999-09-16 | 2001-03-27 | Asahi Kasei Corp | Adhesive for inner lining and bondable inner lining |
| JP2002345875A (en) * | 2001-05-25 | 2002-12-03 | Nitto Denko Corp | Exothermic body |
| US20030190336A1 (en) * | 2002-03-18 | 2003-10-09 | Adams Christine Helga | Personal care compositions comprising solid particles enterapped in a gel network |
| CN1496395A (en) * | 2002-05-20 | 2004-05-12 | 麦考尔株式会社 | Exothermic composition and exothermic body |
| TW200704434A (en) * | 2005-04-18 | 2007-02-01 | Showa Denko Kk | Water-containing gel form and production method thereof |
| CN101325932A (en) * | 2005-12-15 | 2008-12-17 | 金伯利-克拉克环球有限公司 | Therapeutic kit employing a thermal insert |
| RU70792U1 (en) * | 2007-03-20 | 2008-02-20 | Игорь Иванович Пашкин | MEDICAL APPLICATOR |
| JP2009024086A (en) * | 2007-07-19 | 2009-02-05 | Harima Chem Inc | Method of manufacturing supported type solid heat storing material |
| CN101939230A (en) * | 2008-02-06 | 2011-01-05 | 日东来福泰株式会社 | Be used to seal porous membrane, heat-sealing bag member of formation and disposable body warmer with the bag member of formation |
| CN104394814A (en) * | 2012-06-29 | 2015-03-04 | 桐灰化学株式会社 | Heat generation tool |
| JP2014054485A (en) * | 2012-09-14 | 2014-03-27 | Nitto Lifetech Kk | Adhesive member for skin stick-on body warmer and skin stick-on body warmer |
| JP2014074146A (en) * | 2012-10-05 | 2014-04-24 | Double Scope Kk | Porous membrane and manufacturing method thereof |
| CN202950817U (en) * | 2012-11-07 | 2013-05-29 | 浙江三赢医疗器械有限公司 | Inorganic mineral physiotherapy bag |
| CN106414571A (en) * | 2014-06-03 | 2017-02-15 | 三菱树脂株式会社 | Porous film and storage bag |
| CN205054577U (en) * | 2015-10-12 | 2016-03-02 | 天津市山佳医药科技有限公司 | Disconnect -type spontaneous heating eye -shade |
| CN105255453A (en) * | 2015-11-18 | 2016-01-20 | 北京恒天易德生物科技有限公司 | Novel cooling storage agent and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108948392A (en) * | 2018-06-29 | 2018-12-07 | 广东工业大学 | A method of improving polyvinyl alcohol hydrogel mechanical property |
| CN108948392B (en) * | 2018-06-29 | 2021-04-16 | 广东工业大学 | Method for improving mechanical property of polyvinyl alcohol hydrogel |
| CN112336907A (en) * | 2020-10-23 | 2021-02-09 | 紫水晶(海南)再生医学科技有限公司 | Bioactive glass material for hemostasis and repair and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6441894B2 (en) | Poly (meth) acrylic acid (salt) -based particulate water-absorbing agent and production method | |
| CN101787101B (en) | Preparation method of nanometer resin with high hygroscopy | |
| CN101905035B (en) | Method for preparing silk fibroin three-dimensional porous material | |
| CN104368033B (en) | The fiber of high antibacterial fast healing, film and block silk gum base dressing and its preparation method | |
| CN106076272B (en) | A kind of preparation method of adsorbent for heavy metal | |
| CN108948293B (en) | Humic acid-based composite water-retaining agent and preparation method thereof | |
| CN107981967A (en) | A kind of cold compress application for carrying silicate particulate | |
| CN112094625A (en) | Boron nitride nanotube aerogel/phase change heat conduction composite material and preparation method thereof | |
| CN109809481B (en) | Method for preparing titanium dioxide polyhedron with hollow structure by using titanium carbide ultrathin nanosheets | |
| CN102319448A (en) | Antibacterial aquagel material for preparing medical wound dressing and preparation method thereof | |
| CN101066469B (en) | Preparation process of porous collagen sponge | |
| CN108285145A (en) | Three-dimensional multi-level structure nano silicon carbide, preparation method and application thereof | |
| CN106730021A (en) | A kind of bioactivity glass modified gelatin composite aquogel and preparation method thereof | |
| CN104174342A (en) | Beta-tricalcium phosphate/alginic acid composite microsphere and preparation method and application of beta-tricalcium phosphate/alginic acid composite microsphere | |
| CN108517555A (en) | The method for obtaining large-area high-quality flexible self-supporting monocrystalline oxide film based on Van der Waals extension | |
| CN105344334A (en) | Preparation method for polyvinyl alcohol/silicon dioxide composite microspheres | |
| CN107946575A (en) | A kind of preparation method of N doping porous charcoal cladding mesocarbon microspheres and the thus composite material of method preparation and its application | |
| Chang et al. | 3D PCL/collagen nanofibrous medical dressing for one-time treatment of diabetic foot ulcers | |
| CN113117140B (en) | Preparation method of double-stimulus synergistic response porous hydrogel modified acrylic acid bone cement | |
| CN106581766A (en) | Preparation method of collagen-hydroxyapatite stent containing nanometer manganese dioxide | |
| CN111423615B (en) | Method for preparing polymer through hole material by emulsion freezing demulsification and application thereof | |
| CN108219453B (en) | A kind of preparation method of three-dimensional porous grapheme/polyaniline composite material | |
| CN108676111A (en) | A kind of preparation method of field drives intelligent flexible material | |
| CN107080860B (en) | Silk protein sponge and preparation method thereof | |
| CN106753257A (en) | A kind of anti-phase separation gel low-temperature phase-change material and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20190314 Address after: 611130 No. 188, West Section of Kexing Road, Chengdu Cross-Strait Science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Applicant after: SICHUAN SANTAI PHARMACEUTICAL TECHNOLOGY Co.,Ltd. Address before: 610041 Milan Style 922, 29 Xiaotianzhong Street, Wuhou District, Chengdu City, Sichuan Province Applicant before: Yuan Tun Applicant before: Sichuan Santai Pharmaceutical Technology Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180504 |
|
| WD01 | Invention patent application deemed withdrawn after publication |