CN107942464A - A kind of integral micro-lens array apparatus - Google Patents
A kind of integral micro-lens array apparatus Download PDFInfo
- Publication number
- CN107942464A CN107942464A CN201711172230.6A CN201711172230A CN107942464A CN 107942464 A CN107942464 A CN 107942464A CN 201711172230 A CN201711172230 A CN 201711172230A CN 107942464 A CN107942464 A CN 107942464A
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- CN
- China
- Prior art keywords
- fixedly connected
- glass slide
- backplate
- bottom plate
- lens array
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B7/00—Mountings, adjusting means, or light-tight connections, for optical elements
- G02B7/02—Mountings, adjusting means, or light-tight connections, for optical elements for lenses
Abstract
The invention discloses a kind of integral micro-lens array apparatus, the bottom plate upper end is fixedly connected with backplate, it is hollow shell structure inside the backplate, it is fixedly connected in hollow shell structure on the bottom plate in endshield with glass slide, the bottom plate upper end is fixedly connected in glass slide both sides with fixed block, the glass slide upper end is divided into some grid by demarcation strip, it is fixedly connected inside the grid with lenticule, the backplate left end is fixedly connected with opening device, the opening device is fixedly connected with lid, the bottom plate lower end is fixedly connected with one end of spring, the other end of the spring is fixedly connected with fixed cylinder, the fixed cylinder lower end is fixedly connected with support plate, support plate both ends surrounding is fixedly connected with riser.
Description
Technical field：
The present invention relates to microlens array technical field, more particularly to a kind of integral micro-lens array apparatus.
Background technology：
In the prior art, microarray technology is a kind of flat carrier, it above regularly, specifically adsorb gene or
Protein molecule, many units are fitly arranged according to row and column on microarray；One analytical equipment is referred to as microarray, must
Following standard must be met：Well-regulated, micro-scale and plane requirement；Micro-scale makes reaction in kinetics
It is quick to occur, realize the detection of big figureofmerit.
Micro-array chip is usually using normal glass slide glass (1 inch * 3 inches) at present, and there are the following problems for glass slide：
1) glass slide is frangible, is unfavorable for operating；
2) glass surface is not easy to be chemically treated, and in addition the background signal of glass is high, is unfavorable for highly sensitive detection；
3) when carrying out Multi-example reaction on glass slide, easy cross contamination between sample；
Existing defects in prior art practical application, so having much room for improvement.
The content of the invention：
It is an object of the invention to provide a kind of integral micro-lens array apparatus.
The present invention is implemented by following technical solution：A kind of integral micro-lens array apparatus, including bottom plate, backplate, lid, load
Slide, lenticule, demarcation strip, fixed block, riser, support plate, fixed cylinder and spring, the bottom plate upper end is fixed with backplate to be connected
Connect, be hollow shell structure inside the backplate, the hollow shell structure on the bottom plate in endshield is interior to be fixedly connected with glass slide, described
Bottom plate upper end is fixedly connected in glass slide both sides with fixed block, and the glass slide upper end is divided into some grid by demarcation strip,
It is fixedly connected inside the grid with lenticule, the backplate left end is fixedly connected with opening device, the opening device and lid
Son is fixedly connected, and the bottom plate lower end is fixedly connected with one end of spring, and the other end of the spring is fixedly connected with fixed cylinder,
The fixed cylinder lower end is fixedly connected with support plate, and support plate both ends surrounding is fixedly connected with riser.
Further, the opening device includes head rod, rotation axis and the second connecting rod, the head rod
It is fixedly connected with lid, second connecting rod is fixedly connected with backplate, and the head rod and the second connecting rod pass through rotation
Shaft is rotatably connected, and realizes the unlatching of lid, ensure that the convenience replaced to glass slide.
Further, the demarcation strip includes transverse partition panel and longitudinal divider, and the transverse partition panel is in glass slide
Upper transversely arranged, longitudinal divider longitudinal arrangement on glass slide, the transverse partition panel and longitudinal divider arrangement group
Into grid, prevented by grid when carrying out Multi-example reaction on glass slide, easy cross contamination between sample.
Further, 3 springs are fixed with below the support plate, spring realizes the damping to glass slide, solves
The problem of glass slide is frangible.
Further, the place that the bottom plate upper strata is contacted with glass slide is fixedly connected with anti-reflection coating, solves glass
Glass surface is not easy to be chemically treated, and in addition the background signal of glass is high, is unfavorable for highly sensitive detection.
Further, the place that the lid lower end is contacted with backplate is fixedly connected with sealing ring.
Advantages of the present invention：The present invention solves existing for micro-array chip that glass slide is frangible, is unfavorable for operation, glass
Surface is not easy to be chemically treated, and in addition the background signal of glass is high, is unfavorable for highly sensitive detection and when on glass slide
When carrying out Multi-example reaction, between sample the problem of easy cross contamination；Cover shape and size are according to the shape of chip body
Depending on size, in detection process, the sample in chip is heated by the way of being heated from top of closure, is realized
Zero evaporation of sample is detected, efficiently solves the evaporation problems of sample in biomedical detection process, this is for expensive life
Thing reagent is of great significance；In order to improve phosphor collection efficiency, microlens structure of the present invention may be designed as frustum cone structure,
Cylindrical structure, square column structure, six face rod structures or octahedral rod structure etc. turn photo structure, and it is glimmering to change diverging to turn photo structure by this
The direction of light, the fluorescent probe that can be placed in below chip body detect.
Brief description of the drawings：
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is attached drawing needed in technology description to be briefly described, it should be apparent that, drawings in the following description are only this
Some embodiments of invention, for those of ordinary skill in the art, without creative efforts, can be with
Other attached drawings are obtained according to these attached drawings.
Fig. 1 is schematic structural view of the invention；
Fig. 2 is slide configurations schematic diagram in Fig. 1 of the present invention.
1st, bottom plate, 2, backplate, 3, head rod, 4, rotation axis, the 5, second connecting rod, 6, lid, 7, glass slide, 8, micro-
Lens, 9, demarcation strip, 10, fixed block, 11, riser, 12, support plate, 13, fixed cylinder, 14, spring, 15, anti-reflection coating.
Embodiment：
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, those of ordinary skill in the art are obtained every other without creative efforts
Embodiment, belongs to the scope of protection of the invention.
A kind of 8 array apparatus of integral micro-lens, including bottom plate 1, backplate 2, lid 6, glass slide 7, lenticule 8, demarcation strip
9th, fixed block 10, riser 11, support plate 12, fixed cylinder 13 and spring 14,1 upper end of bottom plate is fixedly connected with backplate 2, described
The inside of backplate 2 be hollow shell structure, and the hollow shell structure on the bottom plate 1 in endshield 2 is interior to be fixedly connected with glass slide 7, the bottom
1 upper end of plate is fixedly connected in 7 both sides of glass slide with fixed block 10, and 7 upper end of glass slide is divided into some lattice by demarcation strip 9
Son, the grid inside are fixedly connected with lenticule 8, and 2 left end of backplate is fixedly connected with opening device, the opening device
It is fixedly connected with lid 6,1 lower end of bottom plate is fixedly connected with one end of spring 14, the other end of the spring 14 and fixation
Cylinder 13 is fixedly connected, and 13 lower end of fixed cylinder is fixedly connected with support plate 12, the 12 both ends surrounding of support plate and riser 11
It is fixedly connected.
Further, the opening device includes head rod 3,4 and second connecting rod 5 of rotation axis, and described first connects
Extension bar 3 is fixedly connected with lid 6, and second connecting rod 5 is fixedly connected with backplate 2, and the head rod 3 is connected with second
Bar 5 is rotatably connected by rotation axis 4.
Further, the demarcation strip 9 includes transverse partition panel 9 and longitudinal divider 9, and the transverse partition panel 9 is carrying
It is transversely arranged on slide 7, the longitudinal divider 9 longitudinal arrangement on glass slide 7, the transverse partition panel 9 and longitudinal subdivision
Plate 9 rearranges grid.
Further, the lower section of support plate 12 is fixed with 3 springs 14.
Further, the place that 1 upper strata of bottom plate is contacted with glass slide 7 is fixedly connected with anti-reflection coating 15.
Further, the place that 6 lower end of lid is contacted with backplate 2 is fixedly connected with sealing ring.
Use process：In use, target molecules, such as DNA fragmentation are fixed on the round platform upper surface of lenticule 8, antigen,
Antibody etc., each round platform surface can fix a kind of target molecules, then the multi objective of monocyte sample can be realized in one single chip
Detection, the number of index are directly proportional to the number of lenticule 8；Make round platform surface target molecule and the analyte in detected sample
Reaction bonded under suitable conditions；By the reaction of label and the compound of target molecules-analyte to described to be detected
The reaction condition of analyte and target molecules in sample makees qualitative or quantitative detection；In detection process, using laser or
White light source as the lenticule 8 in excitation source from below vertical irradiation chip, fluorescence PMT that fluorescence molecule is launched,
CCD or CMOS etc. is detected as detector.6 shapes and sizes of lid depending on the shapes and sizes of chip body,
In detection process, the sample in chip is heated by the way of being heated from 6 top of lid, realizes the zero of detection sample
Evaporation, efficiently solves the evaporation problems of sample in biomedical detection process, this has weight for expensive biological reagent
Big meaning；In order to improve phosphor collection efficiency, 8 structure of lenticule of the present invention may be designed as frustum cone structure, cylindrical structure, side
Rod structure, six face rod structures or octahedral rod structure etc. turn photo structure, turn photo structure by this to change the direction of diverging fluorescence, make
Its fluorescent probe that can be placed at below chip body detects.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on, should all be included in the protection scope of the present invention god.
Claims (6)
1. a kind of integral micro-lens array apparatus, it is characterised in that including bottom plate, backplate, lid, glass slide, lenticule, separation
Plate, fixed block, riser, support plate, fixed cylinder and spring, the bottom plate upper end are fixedly connected with backplate, are inside the backplate
Hollow shell structure, is fixedly connected in the hollow shell structure on the bottom plate in endshield, the bottom plate upper end is in glass slide with glass slide
Both sides are fixedly connected with fixed block, and the glass slide upper end is divided into some grid by demarcation strip, inside the grid with it is micro-
Lens are fixedly connected, and the backplate left end is fixedly connected with opening device, and the opening device is fixedly connected with lid, the bottom
Plate lower end is fixedly connected with one end of spring, and the other end of the spring is fixedly connected with fixed cylinder, the fixed cylinder lower end with
Support plate is fixedly connected, and support plate both ends surrounding is fixedly connected with riser.
2. integral micro-lens array apparatus according to claim 1, it is characterised in that the opening device includes first and connects
Extension bar, rotation axis and the second connecting rod, the head rod are fixedly connected with lid, and second connecting rod is fixed with backplate
Connection, the head rod are rotatably connected with the second connecting rod by rotation axis.
3. integral micro-lens array apparatus according to claim 1, it is characterised in that the demarcation strip includes laterally separated
Plate and longitudinal divider, the transverse partition panel is transversely arranged on glass slide, longitudinal divider longitudinal direction on glass slide
Arrangement, the transverse partition panel and longitudinal divider rearrange grid.
4. integral micro-lens array apparatus according to claim 1, it is characterised in that be fixed with 3 below the support plate
A spring.
5. integral micro-lens array apparatus according to claim 4, it is characterised in that the bottom plate upper strata connects with glass slide
Tactile place is fixedly connected with anti-reflection coating.
6. integral micro-lens array apparatus according to claim 1, it is characterised in that the lid lower end is contacted with backplate
Place be fixedly connected with sealing ring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711172230.6A CN107942464A (en) | 2017-11-22 | 2017-11-22 | A kind of integral micro-lens array apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711172230.6A CN107942464A (en) | 2017-11-22 | 2017-11-22 | A kind of integral micro-lens array apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107942464A true CN107942464A (en) | 2018-04-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711172230.6A Pending CN107942464A (en) | 2017-11-22 | 2017-11-22 | A kind of integral micro-lens array apparatus |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1580753A (en) * | 2003-08-01 | 2005-02-16 | 北京博奥生物芯片有限责任公司 | Micro array reaction unit and its use |
| US20090181857A1 (en) * | 2008-01-15 | 2009-07-16 | Academia Sinica | System and method for producing a label-free micro-array biochip |
| CN201278042Y (en) * | 2008-10-29 | 2009-07-22 | 石国清 | Slide tray special for smear device |
| CN102608032A (en) * | 2012-04-10 | 2012-07-25 | 无锡国盛精密模具有限公司 | Integrated micro lens array device |
| CN103364344A (en) * | 2012-04-10 | 2013-10-23 | 无锡国盛精密模具有限公司 | Integrated micro-optics structural array device |
| CN203807566U (en) * | 2013-11-15 | 2014-09-03 | 河南永登铝业有限公司阳城分公司 | Energy-saving device for electrolyzer furnace door |
| CN205426269U (en) * | 2015-12-12 | 2016-08-03 | 重庆荣成玻璃制品有限公司 | Water meter cover |
| CN205558511U (en) * | 2016-04-12 | 2016-09-07 | 国网江苏省电力公司扬州供电公司 | Take protection device's tool to lock |
-
2017
- 2017-11-22 CN CN201711172230.6A patent/CN107942464A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1580753A (en) * | 2003-08-01 | 2005-02-16 | 北京博奥生物芯片有限责任公司 | Micro array reaction unit and its use |
| US20090181857A1 (en) * | 2008-01-15 | 2009-07-16 | Academia Sinica | System and method for producing a label-free micro-array biochip |
| CN201278042Y (en) * | 2008-10-29 | 2009-07-22 | 石国清 | Slide tray special for smear device |
| CN102608032A (en) * | 2012-04-10 | 2012-07-25 | 无锡国盛精密模具有限公司 | Integrated micro lens array device |
| CN103364344A (en) * | 2012-04-10 | 2013-10-23 | 无锡国盛精密模具有限公司 | Integrated micro-optics structural array device |
| CN203807566U (en) * | 2013-11-15 | 2014-09-03 | 河南永登铝业有限公司阳城分公司 | Energy-saving device for electrolyzer furnace door |
| CN205426269U (en) * | 2015-12-12 | 2016-08-03 | 重庆荣成玻璃制品有限公司 | Water meter cover |
| CN205558511U (en) * | 2016-04-12 | 2016-09-07 | 国网江苏省电力公司扬州供电公司 | Take protection device's tool to lock |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180420 |
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