CN107929902A - Trachea cannula tube core and preparation method thereof - Google Patents

Trachea cannula tube core and preparation method thereof Download PDF

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Publication number
CN107929902A
CN107929902A CN201711302365.XA CN201711302365A CN107929902A CN 107929902 A CN107929902 A CN 107929902A CN 201711302365 A CN201711302365 A CN 201711302365A CN 107929902 A CN107929902 A CN 107929902A
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tube core
trachea cannula
parts
moulding
nano
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不公告发明人
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04—Tracheal tubes
    • A61M16/0402—Special features for tracheal tubes not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/02—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04—Tracheal tubes
    • A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1025—Respiratory system
    • A61M2210/1032—Trachea

Abstract

The present invention provides a kind of easy to operate, safe and efficient trachea cannula tube core and preparation method thereof, the trachea cannula tube core includes guidance tip and moulding tube core, the guidance tip stretches out from described moulding tube core one end, the guidance tip is connected with moulding tube core, a kind of trachea cannula, and the trachea cannula tube core outside diameter is less than the trachea cannula internal diameter, the trachea cannula tube core is placed in the trachea cannula, and the trachea cannula length is less than the trachea cannula tube core length.The guidance tip of trachea cannula tube core of the present invention can substitute trachea cannula so that front end during intubation is thinner, it is easier to is inserted into tracheae；Change conventional intubation way, be inserted into advance with thinner guidance tip, trachea cannula is pushed into, it is more safe efficient；It is combined with moulding tube core and guidance tip, while guiding function is ensured, keeps moulding, avoid metal and injure human body, it is safer, combine operation easily, it is cheap, it is easy to make.

Description

Trachea cannula tube core and preparation method thereof
The present invention be applicant on 03 21st, 2016 number of patent application proposed be " 201610162847.9 ", title For the divisional application of the Chinese invention patent application of " a kind of trachea cannula tube core and preparation method thereof ", entire contents are incorporated into Among the application.
Technical field
The invention belongs to medical anesthesia field, and in particular to a kind of trachea cannula tube core and preparation method thereof.
Background technology
Tracheal catheter is used more and more widely as department of anesthesia of hospital, emergency department and larynx section indispensability apparatus.By In being made of plastics on tracheal catheter, quality is relatively soft, its rigidity deficiency, endotracheal intubation is that each Anesthetist is almost every Its operation that will be carried out.Endotracheal intubation refers to during the general anesthesia after patient realizes and disappears, will be by casing and pipe The trachea cannula of core composition inserted by mouth, pharynx, the larynx of patient in the tracheae of patient be used to carrying out patient assisted respiartion or Mechanical ventilation.Since anatomical factors everyone oropharynx larynxs is all without point-blank, it is necessary to chosen with laryngoscope auxiliary laryngoscope Lower jaw is played, glottis can be exposed, trachea cannula could so be inserted.But in many cases, due to anatomy relationship, glottis is very Hardly possible exposure, that is, via laryngoscope aid in photopic vision under be hardly visible glottis be either only capable of seeing glottis edge or can only See a part for epiglottis or epiglottis, or even it cannot be seen that epiglottis.And preoperative interview work can not accurately be sentenced sometimes The height of disconnected glottis position.After often being provoked with laryngoscope, difficult airway is just found to be.
In clinical real work, such Railway Project is had：First, it is necessary to metal is moulding, meets characteristics of human body, because The angle curved for rule of thumb is not necessarily suitable, and a very little is needed only in the case of the edge that may usually view glottis Angle, but the angle needed in the case of can't see glottis is with regard to relatively large, and the angle of ready tube core is improper, Easily cause intubation defeat；Second, it is necessary to well into tracheae, will avoid in bootup process；3rd, in bootup process In, it is necessary to noninvasive environment, to reduce damage；4th, in blind behaviour, the front end needs of guiding are sufficiently fine, can just enter precisely into Tracheae.To solve the problems, such as this, doctor is after using stainless steel wire moulding by patient's epithelium healing feature and sterilizing in the prior art Insert in tracheal catheter, tracheal catheter is kept the shape same with the stainless steel wire after moulding, so as to tracheal catheter Match with the physiological bending of human body epithelium healing, on the one hand due to the north shape of stainless steel wire be by doctor by rule of thumb with hand bending and Into there is certain randomness, it is difficult to ensure and the physiological bending of patient's epithelium healing really matches；On the other hand due to stainless steel Silk is without dedicated and tracheal catheter matching fixing piece so that and stainless steel wire and tracheal catheter need doctor to be operated respectively with hand, For this reason, at least need two doctors to co-operate in endotracheal intubation, if two doctors' cooperations are not tacit, stainless steel wire Before tracheal catheter front end is stretched out in front end just the possibility for injuring patient's Upper airway space, or stainless steel wire front end is from tracheal catheter End is farther out so that stainless steel wire cannot play the role of due moulding.
The content of the invention
To solve the above-mentioned problems, the present invention provides a kind of trachea cannula tube core, and the trachea cannula tube core includes guiding Tip and moulding tube core, the guidance tip stretch out from described moulding tube core one end, the guidance tip and moulding tube core Connection, the guidance tip for Ag-Ti stratum nucleare composite constructions nano modification plastic flexible pipe, the moulding tube core make a living thing doctor With TiZrNbTa systems high entropy alloy material, the trachea cannula tube core is an integral molding structure；Further, the moulding tube core For high entropy alloy material, its expression formula is：（TiaZrb)x(NbcTad)yMZ,5≤a≤30at%, 5≤b≤30at%, 5≤c≤30, 5≤d≤30at%, a+b=x, c+d=y, 10≤x≤60at%, 10≤y≤70at%, M be V, Mo, Sn, W, Mn, Al, Fe, Co, Any one or more in Ni, Cu, Cr and Zn, 0≤z≤30at%, and x+y+z=100；Further, the guidance tip To carry out surface active to the hose base material of preparation, it is compound that Ag-Ti stratum nucleares are covered on the hose base material after completing surface active Structural material is obtained with carrying out nano-antibacterial modification to hose base material after cleaning drying；Further, the trachea cannula pipe Core further includes hand-held end, and the hand-held end is connected to the other end of the moulding tube core in contrast to guidance tip, described to draw It is 2cm-4cm to lead tip length；Further, the trachea cannula tube core is receiving by the Ag-Ti stratum nucleares composite construction The modified plastic flexible pipe of rice be wrapped in moulding tube core one made of the bio-medical TiZrNbTa systems high entropy alloy material into Type is made；A kind of preparation method of trachea cannula tube core, the preparation method include：S1：Prepare hose base material；S2：Prepare Ag- Ti stratum nucleare sandwiches；S3：Hose substrate surface activates；
S4：Prepare the nano modified material of Ag-Ti stratum nucleare composite constructions；S5：S3 is made on hose base material after surface active The covering obtained prepares the nano modified material of Ag-Ti stratum nucleare composite constructions, carries out nano-antibacterial modification to hose substrate surface, obtains ；S6：Prepare moulding tube core；S7：The plastic flexible pipe of the nano modification of the S5 Ag-Ti stratum nucleare composite constructions prepared is wrapped in S6 Outside prepared moulding tube core, carry out being integrally formed encapsulation.
Further, the S1 includes：1-1：According to parts by weight weigh 80-85 parts of polyethylene, 20-25 parts of neoprene, 2-5 parts of polyvinylpyrrolidone, 3-5 parts of chitosan, ethene-α -5-7 parts of ethylene-octene copolymer, cumyl peroxide 5-7 Part, 5-10 parts of acetyl citrate, maleamic acid 8-10 parts double, 4-5 parts of divinyl tetramine, 4-5 parts of lecithin, fimbrin 5-8 parts, 4-5 parts of maleic acid tin octylate, 4-5 parts of thiol methyl tin, 10-12 parts of dispersant, 15-18 parts of antiseptic；1-2：By 1-2 Middle each component is uniformly mixed in mixing and blending machine；1-3：Material after mixing is put into reaction kettle, in vacuum condition Under be heated to 100-120 DEG C, stir 10-20 minute, be cooled to 30-40 DEG C, stirring 5-10 minutes, obtains mixed material；1-4： Mixed material is placed at 180-190 DEG C in double screw extruder and extrudes batten and with pelleter pelletizing, obtain hose base material.
Further, the S2 includes：2-1：Prepare Ag nano particles：AgNO3 is weighed to be dissolved into deionized water, After AgNO3 is completely dissolved, stir while adding trisodium citrate（Na3C6H5O7）, after being vigorously stirred 5min, use syringe Measure the sodium borohydride haved already dissolved into ice-cold deionized water（NaBH4), it is rapidly injected in the solution being vigorously stirred（Institute State AgNO3：The ratio between amount of Na3C6H5O7 materials is 2：5, the AgNO3：NaBH4 is 5：6）, continue to stop after stirring 10min, It is spare that 2d is placed at room temperature, and solution is into crocus, and in whole reaction process, solution colour is gradually by colourless-dark-brown-orange Color, obtains Ag glue；2-2;Diauxic growth：100mL growth solutions are measured, add 1ml ascorbic acid（C6H8O6,0.1mol/L）Draw Grow, obtain the Ag nano particles grown up for the first time, measure 100ml growth solutions, add 1ml ascorbic acid（0.1mol/L） The Ag nano particles that different amounts of first grows up are added in this mixed liquor after stirring evenly, add 0.5mlNaOH（1mol/L）, Trigger growth again, labeled as AgG2, by original AgG2 centrifuge washings（10000r/min, 10min）2 times, it is concentrated into 50ml It is spare；2-3:Ag surfaces are modified：1ul coupling agents are added in 100ml absolute ethyl alcohols, are vigorously stirred in process with micro measure device Measure ammonium hydroxide to be slowly added to, the pH value in system is adjusted between 6-7.A certain amount of AgG2 is added in mixed solution, is put Enter and stablize 20min or so in 40 DEG C of water-bath, be vigorously stirred at the same time, after system temperature stabilization, take the positive tetraethyl titanate of 2UL Add and continue to stir, the sustained response 15h in 40 DEG C of water-baths, obtains Ag-Ti stratum nucleare composite constructions；Further, the S3 For the hose prepared in S1 base material is washed with ethanol, remove substrate surface impurity, after drying, using plasma or UV irradiate into Row surface activation process；Further, the S4 is that the Ag-Ti stratum nucleare composite constructions prepared in S2 are added to a certain amount of go In ionized water and isopropanol mixed liquor, and HCl is added dropwise and adjusts pH value, under mechanical agitation, add silane monomer and ester Class monomer, triggers the hydrophobic antimicrobial masking liquid for the nano modified material that Ag-Ti stratum nucleare composite constructions are made with azodiisobutyronitrile；Into One step, the S5 is the nano modification that the base material after the activation of S3 hose surfaces is added to Ag-Ti stratum nucleare composite constructions The hydrophobic antimicrobial masking liquid of material, while UV light irradiation certain time, it is modified finally repeatedly with deionized water to clean antibacterial surface Base material, drying, you can the plastic flexible pipe of the nano modification of Ag-Ti stratum nucleare composite constructions is made.
Further, the dispersant described in S1 in 1-1 is polyvinyl lactam, lauryl sodium sulfate, fatty acid polyglycol second One kind in diol ester, the vacuum in the 1-3 are 4MPa, and the upper screw speed in the 1-4 is 350~360r/min.
Further, the S6：Prepared by moulding tube core include：6-1 uses metallurgical raw material metal of the purity more than 99.9%, Using after the oxide skin of sand paper and abrasive machine removal raw metal precise is carried out with balance；It is true that 6-2 takes raw material to add respectively Empty electric arc furnaces, upper strata is placed in by the high element of fusing point, covers following low melting point element, and when smelting is required the high element of fusing point It is placed on upper strata；6-3 opens electric arc, and first with small electric arc that upper strata member biscuiting is red, tune up electric current makes upper strata high-melting-point element afterwards After fusing with lower floor elements melt together with；Alloy pig is placed in crucible by 6-4 several times again, and horizontal by 20 ° ~ 40 ° Angle, melt back at least 4 times ensures that chemical compositions are uniform；6-5 uses suction pouring after the abundant melting of foundry alloy is uniform Equipment, alloy inspiration is entered in water cooled copper mould, obtains bio-medical TiZrNbTa systems high-entropy alloy rod.
Beneficial effects of the present invention are as follows：
1）Guidance tip can substitute trachea cannula so that front end during intubation is thinner, it is easier to be inserted into tracheae, Ag-Ti cores The plastic flexible pipe of the nano modification of layer composite construction makes catheter surface not only have high tenacity, but also obtains efficient, lasting, wide spectrum The advantages of antibacterial, it is possible to reduce attachment, bacterial growth, Airway damage and the conduit of trachea cannula conduit surface airway secretions become Shape, elongate catheter indwelling time.
2）Change conventional intubation way, wrapped up by the plastic flexible pipe of the nano modification of the Ag-Ti stratum nucleares composite construction It is integrally formed in moulding tube core made of the bio-medical TiZrNbTa systems high entropy alloy material, it is first with thinner guidance tip Trachea cannula, is then pushed into by row insertion, more safe efficient.
3）It is combined with moulding tube core and guidance tip, while guiding function is ensured, moulding is kept to trachea cannula, Moulding tube core is made a living thing medical Ti ZrNbTa systems high entropy alloy material at the same time, has the mechanical strength of superelevation, low modulus, good Biocompatibility, the tensile strength about 0.8Gpa of the alloy, elongation percentage about 18%, elasticity modulus is less than 60Gpa, and closes Golden component is nontoxic to human body or hypotoxicity element.
4）After Ag ions are surrounded by Ti, Ti forms one layer of unimolecule clad on its surface, introduces and extends on Ag surfaces Outer amino, is conducive to after hydrolysis TiO2 in the deposition growing on Ag surfaces, makes clad more complete fine and close, its modified function Better.
5）Using the iron wire of original cannula core as moulding tube core, keep trachea cannula shape, while by the use of plastic flexible pipe as Guidance tip, instead of metal, avoids metal and injures human body, combine operation easily, cheap, easy to make.
6）The preparation method flow of the present invention is shorter, and easy to operate, cost is low, environmentally friendly, high financial profit.With showing There is technology to compare, the Medical trachea cannula that the method provided by the present invention is prepared has excellent biocompatibility with polythene material And security, the performance of existing Related product on the market is superior to, and its intensity is high, good mechanical property.
Brief description of the drawings
Fig. 1 is the structure chart of trachea cannula tube core of the present invention and trachea cannula.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to the accompanying drawings and embodiments, it is right The present invention is explained in further detail.It should be appreciated that specific embodiment described herein is used only for explaining the present invention, and It is not used in the restriction present invention.On the contrary, the present invention cover it is any be defined by the claims the present invention spirit and scope on do Replacement, modification, equivalent method and scheme.Further, in order to make the public have a better understanding the present invention, below to this It is detailed to describe some specific detail sections in the detailed description of invention.It is thin without these for a person skilled in the art The description of section part can also understand the present invention completely.
The invention will be further described with specific embodiment below in conjunction with the accompanying drawings, but not as a limitation of the invention. Below most preferred embodiment is enumerated for the present invention：
Embodiment 1：Adult type trachea cannula tube core and trachea cannula
As shown in Figure 1, a kind of trachea cannula tube core 4 of the present invention includes guidance tip 1, moulding tube core 2 and hand-held end 3, it is described Guidance tip 1 connects hand-held end 3 by moulding tube core 2.
The guidance tip 1 stretches out from described moulding 2 one end of tube core, and 1 length of guidance tip is 2cm-4cm, The guidance tip 1 is the plastic flexible pipe of the nano modification of Ag-Ti stratum nucleare composite constructions, and 1 outside diameter of guidance tip is 3mm- 5mm, the guidance tip 1 is to carry out surface active to the hose base material of preparation, on the hose base material after completing surface active Ag-Ti stratum nucleares sandwich is covered to carry out nano-antibacterial modification to hose base material, is obtained after cleaning drying.
The moulding tube core 2 is biology medical Ti ZrNbTa systems high entropy alloy material, and the moulding tube core is high-entropy alloy Material, its expression formula are：（TiaZrb)x(NbcTad)yMZ,5≤a≤30at%, 5≤b≤30at%, 5≤c≤30,5≤d≤ 30at%, a+b=x, c+d=y, 10≤x≤60at%, 10≤y≤70at%, M are V, Mo, Sn, W, Mn, Al, Fe, Co, Ni, Cu, Cr And any one or more in Zn, 0≤z≤30at%, and x+y+z=100.
The trachea cannula tube core is to be wrapped in by the plastic flexible pipe of the nano modification of the Ag-Ti stratum nucleares composite construction Moulding tube core made of the bio-medical TiZrNbTa systems high entropy alloy material is integrally formed made.
A kind of preparation method of trachea cannula tube core, the preparation method include：
S1：Prepare hose base material；1-1：80-85 parts of polyethylene, 20-25 parts of neoprene, polyethylene pyrrole are weighed according to parts by weight 2-5 parts of pyrrolidone, 3-5 parts of chitosan, ethene-α -5-7 parts of ethylene-octene copolymer, 5-7 parts of cumyl peroxide, acetyl 5-10 parts of citrate, maleamic acid 8-10 parts double, 4-5 parts of divinyl tetramine, 4-5 parts of lecithin, 5-8 parts of fimbrin, 4-5 parts of maleic acid tin octylate, 4-5 parts of thiol methyl tin, 10-12 parts of dispersant, 15-18 parts of antiseptic；1-2：By each group in 1-2 Divide and be uniformly mixed in mixing and blending machine；1-3：Material after mixing is put into reaction kettle, is heated under vacuum To 100-120 DEG C, stir 10-20 minutes, be cooled to 30-40 DEG C, stir 5-10 minutes, obtain mixed material；1-4：Will mixing Material, which is placed at 180-190 DEG C in double screw extruder, extrudes batten and with pelleter pelletizing, obtains hose base material；The 1- Dispersant in 1 is polyvinyl lactam, one kind in lauryl sodium sulfate, fatty acid polyethylene glycol ester, true in the 1-3 Reciprocal of duty cycle is 4MPa, and the upper screw speed in the 1-4 is 350~360r/min.
S2：Prepare Ag-Ti stratum nucleare sandwiches；2-1：Prepare Ag nano particles：Weigh AgNO3 and be dissolved into deionization In water, after AgNO3 is completely dissolved, stir while adding trisodium citrate（Na3C6H5O7）, after being vigorously stirred 5min, use Syringe measures the sodium borohydride haved already dissolved into ice-cold deionized water（NaBH4), it is rapidly injected in above-mentioned solution（Institute State AgNO3：The ratio between amount of Na3C6H5O7 materials is 2：5, the AgNO3：NaBH4 is 5：6）, continue to stop after stirring 10min, It is spare that 2d is placed at room temperature, and solution is into crocus, and in whole reaction process, solution colour is gradually by colourless-dark-brown-orange Color, obtains Ag glue；2-2；Diauxic growth：100mL growth solutions are measured, add 1ml ascorbic acid（C6H8O6,0.1mol/L）Draw Grow, obtain the Ag nano particles grown up for the first time, measure 100ml growth solutions, add 1ml ascorbic acid（0.1mol/L） The Ag nano particles that different amounts of first grows up are added in this mixed liquor after stirring evenly, add 0.5mlNaOH（1mol/L）, Trigger growth again, labeled as AgG2, by original AgG2 centrifuge washings（10000r/min, 10min）2 times, it is concentrated into 50ml It is spare；2-3:Ag surfaces are modified：1ul coupling agents are added in 100ml absolute ethyl alcohols, are vigorously stirred in process with micro measure device Measure ammonium hydroxide to be slowly added to, the pH value in system is adjusted between 6-7.A certain amount of AgG2 is added in mixed solution, is put Enter and stablize 20min or so in 40 DEG C of water-bath, be vigorously stirred at the same time, after system temperature stabilization, take the positive tetraethyl titanate of 2UL Add and continue to stir, the sustained response 15h in 40 DEG C of water-baths, obtains Ag-Ti stratum nucleare composite constructions；S3：Hose substrate surface Activation；The hose base material prepared in S1 is washed with ethanol, removes substrate surface impurity, after drying, using plasma or UV spokes Shine into row surface activation process；S4：Prepare the nano modified material of Ag-Ti stratum nucleare composite constructions；The Ag-Ti cores that will be prepared in S2 Layer composite construction is added in a certain amount of deionized water and isopropanol mixed liquor, and HCl is added dropwise and adjusts pH value, in mechanical agitation Under effect, silane monomer and esters monomer are added, triggers the nanometer that Ag-Ti stratum nucleare composite constructions are made with azodiisobutyronitrile The hydrophobic antimicrobial masking liquid of modified material；
S5：Covering on hose base material after surface active obtained by S3 prepares the nano modification of Ag-Ti stratum nucleare composite constructions Material, carries out nano-antibacterial modification to hose substrate surface, obtains；S6：Prepare moulding tube core；6-1 is using purity more than 99.9% Metallurgical raw material metal above, precise is carried out using after the oxide skin of sand paper and abrasive machine removal raw metal with balance； 6-2 takes raw material to add vacuum arc furnace ignition respectively, and the high element of fusing point is placed in upper strata, covers following low melting point element, smelts The high element of fusing point is placed on upper strata by Shi Yaoqiu；6-3 opens electric arc, first with small electric arc that upper strata member biscuiting is red, afterwards by electric current Tune up make after the high-melting-point elements melt of upper strata with lower floor elements melt together with；
Alloy pig is placed in crucible by 6-4 several times again, and horizontal by 20 ° ~ 40 ° of angle, melt back 4 times and more than Ensure that chemical composition is uniform；Alloy inspiration, using suction pouring equipment, is entered water cooling by 6-5 after the abundant melting of foundry alloy is uniform In copper mold, bio-medical TiZrNbTa systems high-entropy alloy rod is obtained.S7：By the nanometer of the S5 Ag-Ti stratum nucleare composite constructions prepared Modified plastic flexible pipe is wrapped in outside the moulding tube core prepared by S6, carries out being integrally formed encapsulation.
A kind of trachea cannula 5,5 internal diameter of trachea cannula are more than 4 outside diameter of trachea cannula tube core, and the trachea cannula 5 is The trachea cannula 5 of model specification 6.0-8.5, the trachea cannula tube core 4 are placed in the trachea cannula 5, the trachea cannula 4 length of tube core is more than 5 length of trachea cannula.The guidance tip 1 is located at outside the trachea cannula 5, the moulding tube core 2 In the trachea cannula 5, the hand-held end 3 is located at outside the trachea cannula 5.
In the use of the present invention, hold hand-held end 3, guidance tip 1 is inserted into trachea cannula 5 catheter tip it is outer Side, curves corresponding radian by moulding tube core 2, is inserted with leaning out for guidance tip 1 into tracheae in 5 pipes, and to trachea cannula 5 Carry out it is moulding, with facilitate intubation, start to be intubated after trachea cannula tube core 4 is completely into trachea cannula 5.During intubation, with the right hand Thumb, forefinger and middle finger such as hold pen type handle in conduit, epimere, oral cavity is entered by right bicker, when conduit is close to larynx Pipe end is moved at laryngoscope blade again, while binocular is by the advance side of the close clearance monitoring cannula core between eyeglass and tube wall To guidance tip 1 leggiero accurately is inserted into glottis.By trachea cannula tube core intubation 4 when, when 1 entering tone of guidance tip behind the door, Trachea cannula is inserted into tracheal strips again after moulding tube core 2 should be extracted.Trachea cannula 5 be inserted into endotracheal depth adult for 4~ 5cm, distance about 18~22cm of the guidance tip 1 of trachea cannula tube core 4 to front tooth.After the completion of intubation, trachea cannula 5 is confirmed Tracheal strips are had been enter into fix again.
Embodiment 2：Child form trachea cannula tube core and trachea cannula
As shown in Figure 1, a kind of trachea cannula tube core 4 of the present invention includes guidance tip 1, moulding tube core 2 and hand-held end 3, it is described Guidance tip 1 connects hand-held end 3 by moulding tube core 2.
The guidance tip 1 stretches out from described moulding 2 one end of tube core, and 1 length of guidance tip is 1cm-3cm, The guidance tip 1 is the plastic flexible pipe of the nano modification of Ag-Ti stratum nucleare composite constructions, and 1 outside diameter of guidance tip is 1mm- 3mm, the guidance tip 1 is to carry out surface active to the hose base material of preparation, on the hose base material after completing surface active Ag-Ti stratum nucleares sandwich is covered to carry out nano-antibacterial modification to hose base material, is obtained after cleaning drying.
The moulding tube core 2 is biology medical Ti ZrNbTa systems high entropy alloy material, and the moulding tube core is high-entropy alloy Material, its expression formula are：（TiaZrb)x(NbcTad)yMZ,5≤a≤30at%, 5≤b≤30at%, 5≤c≤30,5≤d≤ 30at%, a+b=x, c+d=y, 10≤x≤60at%, 10≤y≤70at%, M are V, Mo, Sn, W, Mn, Al, Fe, Co, Ni, Cu, Cr And any one or more in Zn, 0≤z≤30at%, and x+y+z=100.
The trachea cannula tube core is to be wrapped in by the plastic flexible pipe of the nano modification of the Ag-Ti stratum nucleares composite construction Moulding tube core made of the bio-medical TiZrNbTa systems high entropy alloy material is integrally formed made.
A kind of preparation method of trachea cannula tube core, the preparation method include：
S1：Prepare hose base material；1-1：80-85 parts of polyethylene, 20-25 parts of neoprene, polyethylene pyrrole are weighed according to parts by weight 2-5 parts of pyrrolidone, 3-5 parts of chitosan, ethene-α -5-7 parts of ethylene-octene copolymer, 5-7 parts of cumyl peroxide, acetyl 5-10 parts of citrate, maleamic acid 8-10 parts double, 4-5 parts of divinyl tetramine, 4-5 parts of lecithin, 5-8 parts of fimbrin, 4-5 parts of maleic acid tin octylate, 4-5 parts of thiol methyl tin, 10-12 parts of dispersant, 15-18 parts of antiseptic；1-2：By each group in 1-2 Divide and be uniformly mixed in mixing and blending machine；1-3：Material after mixing is put into reaction kettle, is heated under vacuum To 100-120 DEG C, stir 10-20 minutes, be cooled to 30-40 DEG C, stir 5-10 minutes, obtain mixed material；1-4：Will mixing Material, which is placed at 180-190 DEG C in double screw extruder, extrudes batten and with pelleter pelletizing, obtains hose base material；The 1- Dispersant in 1 is polyvinyl lactam, one kind in lauryl sodium sulfate, fatty acid polyethylene glycol ester, true in the 1-3 Reciprocal of duty cycle is 4MPa, and the upper screw speed in the 1-4 is 350~360r/min.
S2：Prepare Ag-Ti stratum nucleare sandwiches；2-1：Prepare Ag nano particles：Weigh AgNO3 and be dissolved into deionization In water, after AgNO3 is completely dissolved, stir while adding trisodium citrate（Na3C6H5O7）, after being vigorously stirred 5min, use Syringe measures the sodium borohydride haved already dissolved into ice-cold deionized water（NaBH4), it is rapidly injected in above-mentioned solution（Institute State AgNO3：The ratio between amount of Na3C6H5O7 materials is 2：5, the AgNO3：NaBH4 is 5：6）, continue to stop after stirring 10min, It is spare that 2d is placed at room temperature, and solution is into crocus, and in whole reaction process, solution colour is gradually by colourless-dark-brown-orange Color, obtains Ag glue；2-2;Diauxic growth：100mL growth solutions are measured, add 1ml ascorbic acid（C6H8O6,0.1mol/L）Draw Grow, obtain the Ag nano particles grown up for the first time, measure 100ml growth solutions, add 1ml ascorbic acid（0.1mol/L） The Ag nano particles that different amounts of first grows up are added in this mixed liquor after stirring evenly, add 0.5mlNaOH（1mol/L）, Trigger growth again, labeled as AgG2, by original AgG2 centrifuge washings（10000r/min, 10min）2 times, it is concentrated into 50ml It is spare；2-3:Ag surfaces are modified：1ul coupling agents are added in 100ml absolute ethyl alcohols, are vigorously stirred in process with micro measure device Measure ammonium hydroxide to be slowly added to, the pH value in system is adjusted between 6-7.A certain amount of AgG2 is added in mixed solution, is put Enter and stablize 20min or so in 40 DEG C of water-bath, be vigorously stirred at the same time, after system temperature stabilization, take the positive tetraethyl titanate of 2UL Add and continue to stir, the sustained response 15h in 40 DEG C of water-baths, obtains Ag-Ti stratum nucleare composite constructions；S3：Hose substrate surface Activation；The hose base material prepared in S1 is washed with ethanol, removes substrate surface impurity, after drying, using plasma or UV spokes Shine into row surface activation process；S4：Prepare the nano modified material of Ag-Ti stratum nucleare composite constructions；The Ag-Ti cores that will be prepared in S2 Layer composite construction is added in a certain amount of deionized water and isopropanol mixed liquor, and HCl is added dropwise and adjusts pH value, in mechanical agitation Under effect, silane monomer and esters monomer are added, triggers the nanometer that Ag-Ti stratum nucleare composite constructions are made with azodiisobutyronitrile The hydrophobic antimicrobial masking liquid of modified material；
S5：Covering on hose base material after surface active obtained by S3 prepares the nano modification of Ag-Ti stratum nucleare composite constructions Material, carries out nano-antibacterial modification to hose substrate surface, obtains；S6：Prepare moulding tube core；6-1 is using purity more than 99.9% Metallurgical raw material metal above, precise is carried out using after the oxide skin of sand paper and abrasive machine removal raw metal with balance； 6-2 takes raw material to add vacuum arc furnace ignition respectively, and the high element of fusing point is placed in upper strata, covers following low melting point element, smelts The high element of fusing point is placed on upper strata by Shi Yaoqiu；6-3 opens electric arc, first with small electric arc that upper strata member biscuiting is red, afterwards by electric current Tune up make after the high-melting-point elements melt of upper strata with lower floor elements melt together with；Alloy pig is placed in crucible by 6-4 several times again, And horizontal by 20 ° ~ 40 ° of angle, melt back 4 times and the above ensure that chemical composition is uniform；
6-5, using suction pouring equipment, alloy inspiration is entered in water cooled copper mould, is given birth to after the abundant melting of foundry alloy is uniform Thing medical Ti ZrNbTa systems high-entropy alloy rod；S7：By the plastic flexible pipe of the nano modification of the S5 Ag-Ti stratum nucleare composite constructions prepared It is wrapped in outside the moulding tube core prepared by S6, carries out being integrally formed encapsulation；A kind of trachea cannula 5,5 internal diameter of trachea cannula are big In 4 outside diameter of trachea cannula tube core, the trachea cannula 5 is the trachea cannula 5 of model specification 3.0-5.5, the trachea cannula pipe Core 4 is placed in the trachea cannula 5, and 4 length of trachea cannula tube core is more than 5 length of trachea cannula.The guiding point Outside the trachea cannula 5, the moulding tube core 2 is located in the trachea cannula 5 at end 1, and the hand-held end 3 is positioned at described Outside trachea cannula 5.
In the use of the present invention, hold hand-held end 3, guidance tip 1 is inserted into trachea cannula 5 catheter tip it is outer Side, curves corresponding radian by moulding tube core 2, is inserted with leaning out for guidance tip 1 into tracheae in 5 pipes, and to trachea cannula 5 Carry out it is moulding, with facilitate intubation, start to be intubated after trachea cannula tube core 4 is completely into trachea cannula 5.During intubation, with the right hand Thumb, forefinger and middle finger such as hold pen type handle in conduit, epimere, oral cavity is entered by right bicker, when conduit is close to larynx Pipe end is moved at laryngoscope blade again, while binocular is by the advance side of the close clearance monitoring cannula core between eyeglass and tube wall To guidance tip 1 leggiero accurately is inserted into glottis.By trachea cannula tube core intubation 4 when, when 1 entering tone of guidance tip behind the door, Trachea cannula is inserted into tracheal strips again after moulding tube core 2 should be extracted.Trachea cannula 5 be inserted into endotracheal depth children for 2~ 3cm, distance about 15cm~18cm of the guidance tip 1 of trachea cannula tube core 4 to front tooth.After the completion of intubation, to confirm that tracheae is inserted Pipe 5 has been enter into tracheal strips and fixes again.
One kind of embodiment described above, simply more preferably embodiment of the invention, those skilled in the art The usual variations and alternatives that member carries out in the range of technical solution of the present invention should all include within the scope of the present invention.

Claims (9)

1. a kind of trachea cannula tube core, it is characterised in that the trachea cannula tube core includes guidance tip and moulding tube core, described Guidance tip stretches out from described moulding tube core one end, and the guidance tip is connected with moulding tube core, and the guidance tip is The plastic flexible pipe of the nano modification of Ag-Ti stratum nucleare composite constructions, the moulding tube core high entropy of thing medical Ti ZrNbTa systems of making a living close Golden material, the trachea cannula tube core are an integral molding structure.
2. trachea cannula tube core according to claim 1, it is characterised in that the moulding tube core is high entropy alloy material, its Expression formula is：(TiaZrb)x(NbcTad)yMz, 5≤a≤30at%, 5≤b≤30at%, 5≤c≤30,5≤d≤30at%, a + b=x, c+d=y, 10≤x≤60at%, 10≤y≤70at%, M be V, Mo, Sn, W, Mn, Al, Fe, Co, Ni, Cu, Cr and Any one or more in Zn, 0≤z≤30at%, and x+y+z=100.
3. trachea cannula tube core according to claim 2, it is characterised in that the guidance tip is the hose base material to preparation Surface active is carried out, Ag-Ti stratum nucleares sandwich is covered on the hose base material after completing surface active with to hose base Material carries out nano-antibacterial modification, is obtained after cleaning drying.
4. trachea cannula tube core according to claim 3, it is characterised in that the trachea cannula tube core further includes hand-held end End, the hand-held end are connected to the other end of the moulding tube core in contrast to guidance tip, and the pilot tip length is 2cm-4cm。
5. trachea cannula tube core according to claim 4, it is characterised in that the trachea cannula tube core is by described The plastic flexible pipe of the nano modification of Ag-Ti stratum nucleare composite constructions is wrapped in the bio-medical TiZrNbTa systems high entropy alloy material Manufactured moulding tube core is integrally formed made.
6. a kind of preparation method of trachea cannula tube core, based on the trachea cannula tube core described in one of the claims 1-5, its It is characterized in that, the preparation method includes：
S1：Prepare hose base material；
S2：Prepare Ag-Ti stratum nucleare sandwiches；
S3：Hose substrate surface activates；
S4：Prepare the nano modified material of Ag-Ti stratum nucleare composite constructions；
S5：Covering on hose base material after surface active obtained by S3 prepares the nano modification of Ag-Ti stratum nucleare composite constructions Material, carries out nano-antibacterial modification to hose substrate surface, obtains；
S6：Prepare moulding tube core；
S7：The plastic flexible pipe of the nano modification of the S5 Ag-Ti stratum nucleare composite constructions prepared is wrapped in the shaping conduit prepared by S6 Outside core, carry out being integrally formed encapsulation.
7. preparation method according to claim 6, it is characterised in that the S1 includes：
1-1：80-85 parts of polyethylene, 20-25 parts of neoprene, 2-5 parts of polyvinylpyrrolidone, shell are weighed according to parts by weight to gather It is 3-5 parts sugared, ethene-α -5-7 parts of ethylene-octene copolymer, 5-7 parts of cumyl peroxide, 5-10 parts of acetyl citrate, double 8-10 parts of maleamic acid, 4-5 parts of divinyl tetramine, 4-5 parts of lecithin, 5-8 parts of fimbrin, 4-5 parts of maleic acid tin octylate, 4-5 parts of thiol methyl tin, 10-12 parts of dispersant, 15-18 parts of antiseptic；
1-2：Each component in 1-2 is uniformly mixed in mixing and blending machine；
1-3：Material after mixing is put into reaction kettle, is heated to 100-120 DEG C under vacuum, stirs 10-20 Minute, 30-40 DEG C is cooled to, stirs 5-10 minutes, obtains mixed material；
1-4：Mixed material is placed at 180-190 DEG C in double screw extruder and extrudes batten and with pelleter pelletizing, obtained Hose base material；
The S2 includes：
2-1：Prepare Ag nano particles：Weigh AgNO3It is dissolved into deionized water, AgNO3After being completely dissolved, stir while Add trisodium citrate (Na3C6H5O7), after being vigorously stirred 5min, measured with syringe and have already dissolved into ice-cold deionized water In sodium borohydride (NaBH4), (AgNO is rapidly injected in the solution after being vigorously stirred3：Na3C6H5O7The amount of material it Than for 2：5, the AgNO3：NaBH4For 5：6), continue to stop after stirring 10min, place that 2d is spare, and solution is into orange at room temperature Color, in whole reaction process, solution colour gradually by colourless-dark-brown-crocus, obtains Ag glue；
2-2：Diauxic growth：100mL growth solutions are measured, add 1ml ascorbic acid (C6H8O6, 0.1mol/L) and trigger growth, obtain To the Ag nano particles grown up for the first time, 100ml growth solutions are measured, 1ml ascorbic acid (0.1mol/L) is added and stirs evenly The Ag nano particles that different amounts of first grows up are added in this mixed liquor afterwards, 0.5mlNaOH (1mol/L) is added, triggers again Growth, labeled as AgG2, by original AgG2Centrifuge washing (10000r/min, 10min) 2 times, it is spare to be concentrated into 50ml；
2-3:Ag surfaces are modified：1ul coupling agents are added in 100ml absolute ethyl alcohols, are vigorously stirred in process with micro measure device Measure ammonium hydroxide to be slowly added to, the pH value in system is adjusted between 6-7；A certain amount of AgG is added in mixed solution2, put Enter and stablize 20min or so in 40 DEG C of water-bath, be vigorously stirred at the same time, after system temperature stabilization, take the positive metatitanic acid second of 2UL Ester adds and continues to stir, and the sustained response 15h in 40 DEG C of water-baths, obtains Ag-Ti stratum nucleare composite constructions；
The S3 removes substrate surface impurity, after drying, using plasma for the hose base material prepared in S1 is washed with ethanol Or UV irradiation carries out surface activation process；
The S4 is that the Ag-Ti stratum nucleare composite constructions prepared in S2 are added to a certain amount of deionized water and isopropanol mixed liquor In, and HCl is added dropwise and adjusts pH value, under mechanical agitation, silane monomer and esters monomer are added, uses azodiisobutyronitrile Trigger the hydrophobic antimicrobial masking liquid for the nano modified material that Ag-Ti stratum nucleare composite constructions are made；
The S5 is the nano modified material that the base material after the activation of S3 hose surfaces is added to Ag-Ti stratum nucleare composite constructions Hydrophobic antimicrobial masking liquid, while UV light irradiation certain time, finally repeatedly clean the modified base of antibacterial surface with deionized water Material, drying, you can the plastic flexible pipe of the nano modification of Ag-Ti stratum nucleare composite constructions is made.
8. preparation method according to claim 7, it is characterised in that the dispersant described in S1 in 1-1 is polyethylene acyl One kind in amine, lauryl sodium sulfate, fatty acid polyethylene glycol ester, the vacuum in the 1-3 are 4MPa, in the 1-4 Upper screw speed be 350~360r/min.
9. preparation method according to claim 6, it is characterised in that the S6：Prepared by moulding tube core include：
6-1 uses metallurgical raw material metal of the purity more than 99.9%, and the oxide skin of raw metal is removed using sand paper and abrasive machine Afterwards precise is carried out with balance；
6-2 takes raw material to add vacuum arc furnace ignition respectively, and the high element of fusing point is placed in upper strata, covers following low melting point element, Require the high element of fusing point being placed on upper strata during smelting；
6-3 opens electric arc, first with small electric arc that upper strata member biscuiting is red, afterwards tunes up electric current after making upper strata high-melting-point elements melt Together with lower floor elements melt；
Alloy pig is placed in crucible by 6-4 several times again, and horizontal by 20 °~40 ° of angle, melt back at least 4 times, Ensure that chemical composition is uniform；
6-5, using suction pouring equipment, alloy inspiration is entered in water cooled copper mould, is given birth to after the abundant melting of foundry alloy is uniform Thing medical Ti ZrNbTa systems high-entropy alloy rod.
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