CN107929678A - 一种防治鸡关节炎的纯中药膏剂 - Google Patents

一种防治鸡关节炎的纯中药膏剂 Download PDF

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CN107929678A
CN107929678A CN201610893584.9A CN201610893584A CN107929678A CN 107929678 A CN107929678 A CN 107929678A CN 201610893584 A CN201610893584 A CN 201610893584A CN 107929678 A CN107929678 A CN 107929678A
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葛洪伟
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Abstract

本发明公开了一种防治鸡关节炎的纯中药膏剂，本发明的纯中药膏剂的成分为：松针、大蒜粉、生姜粉、黄连、金银花、黄芪、穿心莲7味中草药以及炼糖、薄荷醇。本发明的制剂纯中药膏剂经过粉碎破壁、冻融破壁、有机萃取、浓缩收膏等制备环节制作而成，通过将膏剂涂抹在鸡的关节处来防治鸡关节炎疾病。本发明的纯中药膏剂具有以下优点：纯中药制剂，绿色环保；从抗病毒、抗菌、物理消炎角度选取中药材，防治多因素造成的鸡关节炎疾病；加有较高含量的透皮剂，使中药有效成分快速通过鸡爪鳞片较厚的角质层和皮肤，到达病灶发挥治疗效果；中药材经过破壁技术和有机萃取技术提炼，有效成分的提取率显著提升，而且药效稳定，作用持久。

Description

一种防治鸡关节炎的纯中药膏剂
技术领域
本发明涉及中兽药技术领域，尤其涉及辅助治疗鸡关节炎疾病的中兽药技术领域。
背景技术
鸡的关节炎疾病在鸡的各个日龄段均可发生，表现为关节肿大、瘸腿、站立不稳。由于无法正常行走，导致采食困难，进一步导致体弱多病。鸡一旦得了关节炎，生产性能将受到严重影响，如果作为肉鸡，得了关节炎的鸡由于卖相差无法销售，降低养殖利润。引起鸡得关节炎的原因有很多，有物理原因，如奔跑扭伤、笼具刮伤；有疾病原因，如病毒性关节炎、沙门氏菌型关节炎、滑液囊支原体型关节炎等。由于导致鸡关节炎疾病的患病原因很多，有的甚至不是一种原因造成，因而鸡得了关节炎后的在治疗方面难度较大。由于鸡爪部位血管分布不多，通过抗病毒和抗生素治疗，治疗剂量较大，在增加治疗成本的同时，也加大了禽肉、禽蛋产品的药物残留，影响产品的品质。
发明内容
本发明是提供一种绿色环保、毒副作用小、安全性高、可有效防治鸡关节炎的鸡用纯中药膏剂。本发明是通过以下方案实现的：
一种防治鸡关节炎的纯中药膏剂，是由松针、大蒜粉、生姜粉、黄连、金银花、黄芪、穿心莲7味中草药以及炼糖、薄荷醇组成，组方各药材的重量配比为：松针35-40份、大蒜粉15-25份、生姜粉15-25份、黄连6-18份、金银花6-18份、黄芪2-6份、穿心莲2-6份，炼糖作为收膏剂起收膏作用；薄荷醇作为透皮剂协助中药有效成分透过鸡爪关节处的角质层和皮肤。
一种防治鸡关节炎的纯中药膏剂的制备方法为：(1)按组方重量配比称取各药材，经过初级破壁粉碎加工成500目的药粉，将加工成的药粉置于-25℃的温度下冷冻24小时；(2)将步骤(1)冷冻24小时之后的药粉取出，在25℃的温度下解冻，通过冻融原理使中药粉再次得到破壁处理；(3)将步骤(2)解冻后的中药粉与一定量95％的乙醇溶液混合，常温下浸提3h，抽滤，重复3次，合并滤液，减压蒸馏，挥去乙醇，并在水浴恒温为60℃的真空旋转仪上浓缩，制成相对密度1.18-1.25的清膏；(4)称取步骤(3)的清膏，同时称取炼糖、薄荷醇，清膏、炼糖、薄荷醇的三者重量比45∶50∶5；(5)将炼糖和薄荷醇混合，加入炼糖重量50％的水混合加热搅拌至金黄色时，与上述清膏混合，再浓缩至相对密度1.35，制成本发明防治鸡关节炎的纯中药膏剂。
本发明的纯中药膏剂具有以下优点：(1)纯中药制剂，绿色环保；(2)从抗病毒、抗菌、物理消炎角度选取中药材，防治多因素造成的鸡关节炎疾病；(3)加有较高含量的透皮剂，通过药膏涂抹方式在鸡关节部位给药，使中药有效成分快速通过鸡爪鳞片较厚的角质层和皮肤，到达病灶发挥治疗效果；(4)中药材经过破壁技术和有机萃取技术提炼，有效成分的提取率显著提升，而且药效稳定，作用持久。
具体实施方式
以下是本发明的实施例，本发明的实际使用并不局限于实施例。
实施例一：
一种防治鸡关节炎的纯中药膏剂：组方各药材的按照重量配比为：松针35份、大蒜粉15份、生姜粉15份、黄连15份、金银花15份、黄芪3份、穿心莲2份。将上述药经过初级破壁粉碎加工成500目的药粉，将加工成的药粉置于-25℃的温度下冷冻24小时后在25℃的温度下解冻，将解冻后的中药粉与一定量95％的乙醇溶液混合，常温下浸提3h，抽滤，重复3次，合并滤液，减压蒸馏，挥去乙醇，并在水浴恒温为60℃的真空旋转仪上浓缩，制成相对密度1.18-1.25的清膏；按照重量比为45∶50∶5称取清膏、炼糖、薄荷醇；将炼糖和薄荷醇混合，加入炼糖重量50％的水混合加热搅拌至金黄色时，与上述清膏混合，再浓缩至相对密度1.35，制成本发明防治鸡关节炎的纯中药膏剂。2015年1月11日，在兴化明灿商品代蛋鸡场，将该场当日出雏的7800羽雏鸡苗随机平均分为2组，每组3900羽。试验组在雏鸡1日龄全群在雏鸡关节处涂抹膏剂。另将站立不稳、关节红肿的雏鸡单独隔离，隔离鸡群每周在患病处涂抹一次膏剂。至育雏结束，试验组鸡群关节炎发病率为2.81％，关节炎患病治愈率为75.2％；对照组鸡群关节炎发病率为8.81％，对照组关节炎患病鸡群采取常规治疗，治愈率为39.3％，取得了本发明所述的有益效果。
实施例二：
一种防治鸡关节炎的纯中药膏剂：组方各药材的按照重量配比为：松针30份、大蒜粉20份、生姜粉20份、黄连10份、金银花10份、黄芪5份、穿心莲5份。将上述药经过初级破壁粉碎加工成500目的药粉，将加工成的药粉置于-25℃的温度下冷冻24小时后在25℃的温度下解冻，将解冻后的中药粉与一定量95％的乙醇溶液混合，常温下浸提3h，抽滤，重复3次，合并滤液，减压蒸馏，挥去乙醇，并在水浴恒温为60℃的真空旋转仪上浓缩，制成相对密度1.18-1.25的清膏；按照重量比为45∶50∶5称取清膏、炼糖、薄荷醇；将炼糖和薄荷醇混合，加入炼糖重量50％的水混合加热搅拌至金黄色时，与上述清膏混合，再浓缩至相对密度1.35，制成本发明防治鸡关节炎的纯中药膏剂。2015年5月26日，在兴化明灿商品代蛋鸡场，选取该场商品代育成阶段患有关节炎后备鸡298羽，随机分为对照组和试验组，每组各149羽。对照组采用常规方法治疗，试验组每日在患病部位涂抹药膏2次，连续治疗5天。治疗结果为：试验组有效治疗率85.9％，对照组有效治疗率为44.3％，取得了本发明所述的有益效果。
实施例三：
一种防治鸡关节炎的纯中药膏剂：组方各药材的按照重量配比为：松针30份、大蒜粉25份、生姜粉18份、黄连8份、金银花8份、黄芪6份、穿心莲5份。将上述药经过初级破壁粉碎加工成500目的药粉，将加工成的药粉置于-25℃的温度下冷冻24小时后在25℃的温度下解冻，将解冻后的中药粉与一定量95％的乙醇溶液混合，常温下浸提3h，抽滤，重复3次，合并滤液，减压蒸馏，挥去乙醇，并在水浴恒温为60℃的真空旋转仪上浓缩，制成相对密度1.18-1.25的清膏；按照重量比为45∶50∶5称取清膏、炼糖、薄荷醇；将炼糖和薄荷醇混合，加入炼糖重量50％的水混合加热搅拌至金黄色时，与上述清膏混合，再浓缩至相对密度1.35，制成本发明防治鸡关节炎的纯中药膏剂。2016年6月16日，在兴化明灿商品代蛋鸡场，选取该场商品代产蛋阶段患有关节炎的产蛋鸡128羽，随机分为对照组和试验组，每组各64羽。对照组采用常规方法治疗，试验组每日在患病部位涂抹药膏2次，连续治疗5天。治疗结果为：试验组有效治疗率87.1％，对照组有效治疗率为31.8％，取得了本发明所述的有益效果。
虽然在上文中，已经用一般性说明和具体实施例对本发明作了详细描述，但在本发明的基础上，可以对之进行一些修改和改进，这在本领域技术人员中是显而易见的。因此，在不偏离本发明精神的基础上所做出的修改和改进，均属于本发明要求的保护范围。

Claims (4)

1.一种防治鸡关节炎的纯中药膏剂，其特征在于：膏剂的成分是由松针、大蒜粉、生姜粉、黄连、金银花、黄芪、穿心莲7味中草药以及炼糖、薄荷醇组成。
2.根据权利要求1所述的一种防治鸡关节炎的纯中药膏剂，其中药组方重量配比为：松针35-40份、大蒜粉15-25份、生姜粉15-25份、黄连6-18份、金银花6-18份、黄芪2-6份、穿心莲2-6份。
3.根据权利要求1所述的一种防治鸡关节炎的纯中药膏剂，其中药提取清膏、炼糖、薄荷醇的三者重量比45∶50∶5。
4.根据权利要求1所述的一种防治鸡关节炎的纯中药膏剂，其特征是按如下步骤进行：
(1)将松针、大蒜粉、生姜粉、黄连、金银花、黄芪、穿心莲7味中草药，按组方重量配比称取各药材，经过初级破壁粉碎加工成500目的药粉，将加工成的药粉置于-25℃的温度下冷冻24小时；
(2)将步骤(1)冷冻24小时之后的药粉取出，在25℃的温度下解冻，通过冻融原理使中药粉再次得到破壁处理；
(3)将步骤(2)解冻后的中药粉与一定量95％的乙醇溶液混合，常温下浸提3h，抽滤，重复3次，合并滤液，减压蒸馏，挥去乙醇，并在水浴恒温为60℃的真空旋转仪上浓缩，制成相对密度1.18-1.25的清膏；
(4)称取步骤(3)的清膏，与炼糖、薄荷醇按照重量比为45∶50∶5进行称重；
(5)将炼糖和薄荷醇混合，加入炼糖重量50％的水混合加热搅拌至金黄色时，与上述清膏混合，再浓缩至相对密度1.35，制成本发明通过腹脐给药降低雏鸡沙门氏菌感染率的纯中药膏剂。
CN201610893584.9A 2016-10-12 2016-10-12 一种防治鸡关节炎的纯中药膏剂 Pending CN107929678A (zh)

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