CN107929264B - 双醋瑞因缓释微球及其制备方法 - Google Patents
双醋瑞因缓释微球及其制备方法 Download PDFInfo
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- CN107929264B CN107929264B CN201711262784.5A CN201711262784A CN107929264B CN 107929264 B CN107929264 B CN 107929264B CN 201711262784 A CN201711262784 A CN 201711262784A CN 107929264 B CN107929264 B CN 107929264B
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- diacerein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
实施例 | PVA浓度 | 载药量(%) | 包封率(%) |
1 | 0.5% | 13.39 | 41.87 |
2 | 1% | 14.75 | 51.63 |
3 | 2% | 13.49 | 50.61 |
实施例 | 双醋瑞因与PLGA质量比 | 载药量(%) | 包封率(%) |
4 | 1:5 | 9.82 | 41.74 |
5 | 1:10 | 4.89 | 49.57 |
6 | 1:20 | 3.61 | 54.23 |
实施例 | 相体积比 | 载药量(%) | 包封率(%) |
7 | 1:5 | 9.06 | 46.47 |
8 | 1:10 | 7.25 | 44.45 |
9 | 1:15 | 6.14 | 41.60 |
实施例 | PLGA浓度 | 载药量(%) | 包封率(%) |
10 | 25mg/mL | 5.68 | 39.1 |
11 | 30mg/mL | 7.59 | 45.3 |
12 | 35mg/mL | 8.54 | 69.4 |
Claims (6)
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CN201711262784.5A CN107929264B (zh) | 2017-12-04 | 2017-12-04 | 双醋瑞因缓释微球及其制备方法 |
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CN201711262784.5A CN107929264B (zh) | 2017-12-04 | 2017-12-04 | 双醋瑞因缓释微球及其制备方法 |
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CN107929264A CN107929264A (zh) | 2018-04-20 |
CN107929264B true CN107929264B (zh) | 2020-04-24 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04009698A (es) * | 2004-10-04 | 2006-04-05 | Maria Elena Garcia Armenta | Formulaciones farmaceuticas solidas conteniendo diacereina y meloxicam. |
CN101019847A (zh) * | 2007-03-19 | 2007-08-22 | 上海慈瑞医药科技有限公司 | 二乙酰大黄酸缓释制剂及其制备方法 |
CN103110617A (zh) * | 2013-03-22 | 2013-05-22 | 中国人民解放军肾脏病研究所 | 一种双醋瑞因在制备治疗糖尿病肾病药物中的用途 |
EP2954895A1 (en) * | 2014-06-11 | 2015-12-16 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical combinations of controlled release flurbiprofen and diacerein |
CN106692109A (zh) * | 2017-01-02 | 2017-05-24 | 佛山市腾瑞医药科技有限公司 | 一种微孔膜控释包衣双醋瑞因微丸及其制备方法 |
CN108348646A (zh) * | 2016-08-12 | 2018-07-31 | 高丽大学校产学协力团 | 用于预防或治疗软组织疾病的多孔聚合物微球及其制造方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI473610B (zh) * | 2008-10-28 | 2015-02-21 | Twi Biotechnology Inc | 包含雙醋瑞因(diacerein)之醫藥組合物 |
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2017
- 2017-12-04 CN CN201711262784.5A patent/CN107929264B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04009698A (es) * | 2004-10-04 | 2006-04-05 | Maria Elena Garcia Armenta | Formulaciones farmaceuticas solidas conteniendo diacereina y meloxicam. |
CN101019847A (zh) * | 2007-03-19 | 2007-08-22 | 上海慈瑞医药科技有限公司 | 二乙酰大黄酸缓释制剂及其制备方法 |
CN103110617A (zh) * | 2013-03-22 | 2013-05-22 | 中国人民解放军肾脏病研究所 | 一种双醋瑞因在制备治疗糖尿病肾病药物中的用途 |
EP2954895A1 (en) * | 2014-06-11 | 2015-12-16 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical combinations of controlled release flurbiprofen and diacerein |
CN108348646A (zh) * | 2016-08-12 | 2018-07-31 | 高丽大学校产学协力团 | 用于预防或治疗软组织疾病的多孔聚合物微球及其制造方法 |
CN106692109A (zh) * | 2017-01-02 | 2017-05-24 | 佛山市腾瑞医药科技有限公司 | 一种微孔膜控释包衣双醋瑞因微丸及其制备方法 |
Non-Patent Citations (3)
Title |
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Development, characterization and in vitro evaluation of biodegradable rhein-loaded microparticles for treatment of osteoarthritis;Carolina Gómez-Gaete etal;《European Journal of Pharmaceutical Sciences》;20161006;第96卷;第390页摘要,第391页左栏第3段,第391页右栏第3段,第393页表1,第393页右栏最后一段,第394页左栏第1段和第395页图5 * |
Diacerein-Loaded novel gastroretentive nanofiber system using PLLA: Development and in vitro characterization;Raffi Malik etal;《Artificial Cells, Nanomedicine, and Biotechnology》;20150331;第44卷(第3期);第928-936页 * |
微球给药***在骨性关节炎治疗中的应用;夏晓君;《中国生化药物杂志》;20150728;第35卷(第7期);第185-188页 * |
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