CN107928703A - A kind of biological information imaging device and method - Google Patents
A kind of biological information imaging device and method Download PDFInfo
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- CN107928703A CN107928703A CN201610887484.5A CN201610887484A CN107928703A CN 107928703 A CN107928703 A CN 107928703A CN 201610887484 A CN201610887484 A CN 201610887484A CN 107928703 A CN107928703 A CN 107928703A
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Abstract
The invention discloses a kind of biological information imaging device, it is made of low-frequency oscillation system and ultrasonic image-forming system, the low-frequency oscillation system first ultrasonic probe that shakes by low-frequency oscillator and singly forms, and the low-frequency oscillator is coupled with first ultrasonic probe that singly shakes;The ultrasonic image-forming system includes the first signal generator, secondary signal generator, PC machine and oscillograph, one end of first signal generator is connected on low-frequency oscillator, the other end is connected in PC machine, one end of the secondary signal generator passes sequentially through power amplifier and protection circuit is connected on low-frequency oscillator, the other end is also connected in PC machine, the low-frequency oscillator passes sequentially through attenuator, bandpass filter, amplifier, impulse ejection/receiving instrument, data collecting card is connected in PC machine, the amplifier is connected on same oscillograph with data collecting card, the PC machine is connected with display.
Description
Technical field
The present invention relates to technical field of biological information, and in particular to a kind of biological information imaging device and method.
Background technology
One image can include substantial amounts of biological information, no matter in biology or medical research field, research-on-research
Person is intended to obtain a directly perceived, clearly static or dynamic image, to analyze cell or organism specific region
Feature, state, or even the information such as the expression of specific molecular, distribution.Wherein, Photobiology is imaged since its detecting instrument develops into
Ripe, high sensitivity, contrast height, high resolution, imaging is directly perceived, image taking speed is fast and the advantages that lossless detection is widely used.
It is seeking the pathogenesis of disease, clinical manifestation, gene lesion, understands corresponding physiology and pathological information, and disease is examined
Disconnected and new exploitation of medical procedure etc. has important practice significance and application prospect.
Photobiology is imaged(Optical Imaging)Refer to utilize optical detection means combination optical detection molecule pair
Cell or tissue even organism are imaged, to obtain the method for biological information therein.If Photobiology into
As being limited to visible ray and near infrared range, the different Photobiology imaging according to detection mode can be divided into fluorescence imaging, life
Thing luminescence imaging, photoacoustic imaging, optical fault tomography etc..
Photobiology imaging has very long applicating history, just has some researchers trial from the twentieth century later stage eighties
The fluorescent dye of the injection of exogenous agent as a comparison into organism, combined by way of non-intruding in peep realize optics survey
Amount, to differentiate the normal and ill region of tumour.Development of the Photobiology imaging dependent on optical molecular probe, its milestone formula
Application be in 1994, after Chalfie etc. realizes the successful expression of fluorescin.Fluorescin is a kind of ideal
In vivo marker molecule, it is nontoxic, does not influence the function of biology, can voluntarily be synthesized in the cell after transfection, thus is very suitable for living
Body marks.Fluorescin is applied in various biological studies rapidly, particularly the research of tumour.The hair of several fluorescins
(Osamu Shimomura), Martin Cha Erfei (Martin Charfie) and Qian Yongjian repair in existing person and researcher, lower village
(Roger Tsien) therefore obtain the Nobel chemistry Prize of 2008.
Country is clearly by biological industry(Containing medical instrument)Seven Great Wars of development are supported as emphasis during " 12th Five-Year Plan "
Slightly one of new industry.Ultrasonic Elasticity Imaging is typical basic medical apparatus key core technology, complies fully with " 12
Strategic of the China on medical device technology and industry during five ".Therefore, quantitative ultrasound elastogram skill is researched and developed
Art and corresponding instrument equipment have important social value and economic value, on the one hand realize that liver fibrosis/hepatic sclerosis, mammary gland swell
The noninvasive of the soft tissue lesions such as knurl, early stage, Precise Diagnosis, achieve the purpose that early discovery, early treatment, meet China's clinical ultrasound
Great demand, improves the general level of the health of China human mortality;On the other hand for promoting China's novel ultrasonic diagnostic techniques and instrument to set
The development of standby and high-end color ultrasound key technology is significant, is conducive to change the competition situation of high-end color ultrasound both at home and abroad, is
Medical instrument enterprise of China brings more preferable economic benefit.
The content of the invention
In view of the above problems, the present invention provides a kind of biological information imaging device and method, which is based on shearing
The ultrasonic Transient elastography system of ripple, the equipment utilization power amplifier, excites low-frequency oscillator using unlike signal, obtains
Different degrees of image information, can effectively carry out the comparison of image information, obtain more biological informations, can effectively solve
Certainly in background technology the problem of.
To achieve these goals, the technical solution adopted by the present invention is as follows:A kind of biological information imaging device, by low frequency
Oscillatory system and ultrasonic image-forming system composition, the low-frequency oscillation system first ultrasonic probe that shakes by low-frequency oscillator and singly form,
The low-frequency oscillator is coupled with first ultrasonic probe that singly shakes;The ultrasonic image-forming system include the first signal generator,
Secondary signal generator, PC machine and oscillograph, one end of first signal generator are connected on low-frequency oscillator, the other end
It is connected in PC machine, one end of the secondary signal generator passes sequentially through power amplifier and protection circuit is connected to low frequency and shakes
Swing on device, the other end is also connected in PC machine, and the low-frequency oscillator passes sequentially through attenuator, bandpass filter, amplifier, arteries and veins
Rush transmitting/receiving instrument, data collecting card is connected in PC machine, the amplifier and data collecting card are connected to same oscillograph
On, the PC machine is connected with display.
Preferably, first ultrasonic probe that singly shakes uses 5MHz, focus 35mm.
In addition the present invention have also been devised a kind of biological information imaging method, include the following steps:
(1)The first signal generator is closed, secondary signal generator is opened, by operating PC machine so that secondary signal generator
The single sine wave of a 50Hz is produced, excites low-frequency oscillator to produce the vibration that an amplitude is 1mm by power amplifier,
Organization internal is passed to by body surface, excitation soft tissue produces a micro-strain;Using ultrasonic image-forming system, pass through attenuator tune
The size of whole collection signal, then the frequency component of other scopes is decayed to by extremely low level by bandpass filter, pass through amplification
The signal of collection is amplified by device, then amplified signal is stored in PC by impulse ejection/receiving instrument, data collecting card
On machine, and waveform is shown in oscillograph, image display is on display, for signal analysis;
(2)Secondary signal generator is closed, the first signal generator is opened, by operating PC machine so that the first signal generator
The single sine wave of a 50Hz is produced, organization internal is directly passed to by body surface, excitation soft tissue produces a micro-strain;
The rf echo signal collected is recorded in PC machine by data collecting card using ultrasonic image-forming system, is shown in display
Device, for signal analysis;
(3)Compare step(1)And step(2)Obtained imaging data.
Beneficial effects of the present invention:
The present invention is the ultrasonic Transient elastography system based on shearing wave, the equipment utilization power amplifier, using different letters
Number excitation low-frequency oscillator, obtains different degrees of image information, can effectively carry out the comparison of image information, obtains more
Biological information.
Brief description of the drawings
Fig. 1 is structure diagram of the present invention.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to the accompanying drawings and embodiments, it is right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
Embodiment
With reference to shown in Fig. 1, the present invention provides a kind of biological information imaging device, by low-frequency oscillation system and ultrasonic imaging system
System composition, the low-frequency oscillation system first ultrasonic probe that shakes by low-frequency oscillator and singly form, and the low-frequency oscillator is with singly shaking
First ultrasonic probe is coupled;First ultrasonic probe that singly shakes uses 5MHz, focus 35mm, the ultrasonic image-forming system bag
Include the first signal generator, secondary signal generator, PC machine and oscillograph, one end of first signal generator is connected to low
On frequency oscillator, the other end is connected in PC machine, and one end of the secondary signal generator passes sequentially through power amplifier and guarantor
Protection circuit is connected on low-frequency oscillator, and the other end is also connected in PC machine, and the low-frequency oscillator passes sequentially through attenuator, band
Bandpass filter, amplifier, impulse ejection/receiving instrument, data collecting card are connected in PC machine, the amplifier and data collecting card
It is connected on same oscillograph, the PC machine is connected with display.
Its imaging method, includes the following steps:
(1)The first signal generator is closed, secondary signal generator is opened, by operating PC machine so that secondary signal generator
The single sine wave of a 50Hz is produced, excites low-frequency oscillator to produce the vibration that an amplitude is 1mm by power amplifier,
Organization internal is passed to by body surface, excitation soft tissue produces a micro-strain;Using ultrasonic image-forming system, pass through attenuator tune
The size of whole collection signal, then the frequency component of other scopes is decayed to by extremely low level by bandpass filter, pass through amplification
The signal of collection is amplified by device, then amplified signal is stored in PC by impulse ejection/receiving instrument, data collecting card
On machine, and waveform is shown in oscillograph, image display is on display, for signal analysis;
(2)Secondary signal generator is closed, the first signal generator is opened, by operating PC machine so that the first signal generator
The single sine wave of a 50Hz is produced, organization internal is directly passed to by body surface, excitation soft tissue produces a micro-strain;
The rf echo signal collected is recorded in PC machine by data collecting card using ultrasonic image-forming system, is shown in display
Device, for signal analysis;
(3)Compare step(1)And step(2)Obtained imaging data;
Low-frequency oscillator:Model 4810, place of production Denmark;
Power amplifier:Amplifier research 100A150B, the U.S.;
Data collecting card:GAGE CS8227,100MHz sample rates, 12 bit resolutions;
Ultrasonic elastograph imaging basic principle:Tissue applied inside (including itself) or it is exterior dynamically or statically/
Quasi-static excitation, the physics laws such as Elasticity, biomethanics effect under, tissue will produce one response, such as displacement, should
Become, the distribution of speed produces certain change and utilizes ultrasonic imaging method, the skill of combined digital signal processing or Digital Image Processing
Art, it is estimated that the corresponding situation of organization internal, so as to directly or indirectly reflect the mechanics categories such as the elasticity modulus of organization internal
The difference present invention of property is the ultrasonic Transient elastography system based on shearing wave, the equipment utilization power amplifier, using not
With signal excitation low-frequency oscillator, different degrees of image information is obtained, the comparison of image information can be effectively carried out, obtain
More biological informations.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should all be included in the protection scope of the present invention.
Claims (3)
- A kind of 1. biological information imaging device, it is characterised in that it is made of low-frequency oscillation system and ultrasonic image-forming system, it is described low Frequency oscillatory system first ultrasonic probe that shakes by low-frequency oscillator and singly forms, and the low-frequency oscillator is coupled with first ultrasonic probe that singly shakes Together;The ultrasonic image-forming system includes the first signal generator, secondary signal generator, PC machine and oscillograph, and described One end of one signal generator is connected on low-frequency oscillator, and the other end is connected in PC machine, the secondary signal generator One end passes sequentially through power amplifier and protection circuit is connected on low-frequency oscillator, and the other end is also connected in PC machine, described Low-frequency oscillator passes sequentially through attenuator, bandpass filter, amplifier, impulse ejection/receiving instrument, data collecting card and is connected to PC On machine, the amplifier is connected on same oscillograph with data collecting card, and the PC machine is connected with display.
- A kind of 2. biological information imaging device according to claim 1, it is characterised in that first ultrasonic probe that singly shakes Using 5MHz, focus 35mm.
- 3. a kind of biological information imaging method, it is characterised in that include the following steps:(1)The first signal generator is closed, secondary signal generator is opened, by operating PC machine so that secondary signal generator The single sine wave of a 50Hz is produced, excites low-frequency oscillator to produce the vibration that an amplitude is 1mm by power amplifier, Organization internal is passed to by body surface, excitation soft tissue produces a micro-strain;Using ultrasonic image-forming system, pass through attenuator tune The size of whole collection signal, then the frequency component of other scopes is decayed to by extremely low level by bandpass filter, pass through amplification The signal of collection is amplified by device, then amplified signal is stored in PC by impulse ejection/receiving instrument, data collecting card On machine, and waveform is shown in oscillograph, image display is on display, for signal analysis;(2)Secondary signal generator is closed, the first signal generator is opened, by operating PC machine so that the first signal generator The single sine wave of a 50Hz is produced, organization internal is directly passed to by body surface, excitation soft tissue produces a micro-strain; The rf echo signal collected is recorded in PC machine by data collecting card using ultrasonic image-forming system, is shown in display Device, for signal analysis;(3)Compare step(1)And step(2)Obtained imaging data.
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Citations (5)
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US20020068870A1 (en) * | 2000-07-20 | 2002-06-06 | Alam Sheikh Kaisar | Hand held mechanical compression device for inducing tissue strain |
CN101869485A (en) * | 2010-06-23 | 2010-10-27 | 深圳大学 | Ultrasonic imaging method and device |
CN102283679A (en) * | 2011-08-04 | 2011-12-21 | 中国科学院深圳先进技术研究院 | Ultrasonic imaging system for elasticity measurement and method for measuring elasticity of biological tissue |
CN105147327A (en) * | 2015-06-12 | 2015-12-16 | 深圳大学 | Generation method for multi-frequency shear wave |
CN105844645A (en) * | 2016-03-31 | 2016-08-10 | 深圳大学 | Instantaneous elasticity imaging code detection method and system |
-
2016
- 2016-10-12 CN CN201610887484.5A patent/CN107928703A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020068870A1 (en) * | 2000-07-20 | 2002-06-06 | Alam Sheikh Kaisar | Hand held mechanical compression device for inducing tissue strain |
CN101869485A (en) * | 2010-06-23 | 2010-10-27 | 深圳大学 | Ultrasonic imaging method and device |
CN102283679A (en) * | 2011-08-04 | 2011-12-21 | 中国科学院深圳先进技术研究院 | Ultrasonic imaging system for elasticity measurement and method for measuring elasticity of biological tissue |
CN105147327A (en) * | 2015-06-12 | 2015-12-16 | 深圳大学 | Generation method for multi-frequency shear wave |
CN105844645A (en) * | 2016-03-31 | 2016-08-10 | 深圳大学 | Instantaneous elasticity imaging code detection method and system |
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