CN107928703A - A kind of biological information imaging device and method - Google Patents

A kind of biological information imaging device and method Download PDF

Info

Publication number
CN107928703A
CN107928703A CN201610887484.5A CN201610887484A CN107928703A CN 107928703 A CN107928703 A CN 107928703A CN 201610887484 A CN201610887484 A CN 201610887484A CN 107928703 A CN107928703 A CN 107928703A
Authority
CN
China
Prior art keywords
low
machine
signal generator
frequency oscillator
frequency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610887484.5A
Other languages
Chinese (zh)
Inventor
魏霖静
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gansu Agricultural University
Original Assignee
Gansu Agricultural University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gansu Agricultural University filed Critical Gansu Agricultural University
Priority to CN201610887484.5A priority Critical patent/CN107928703A/en
Publication of CN107928703A publication Critical patent/CN107928703A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/485Diagnostic techniques involving measuring strain or elastic properties

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

The invention discloses a kind of biological information imaging device, it is made of low-frequency oscillation system and ultrasonic image-forming system, the low-frequency oscillation system first ultrasonic probe that shakes by low-frequency oscillator and singly forms, and the low-frequency oscillator is coupled with first ultrasonic probe that singly shakes;The ultrasonic image-forming system includes the first signal generator, secondary signal generator, PC machine and oscillograph, one end of first signal generator is connected on low-frequency oscillator, the other end is connected in PC machine, one end of the secondary signal generator passes sequentially through power amplifier and protection circuit is connected on low-frequency oscillator, the other end is also connected in PC machine, the low-frequency oscillator passes sequentially through attenuator, bandpass filter, amplifier, impulse ejection/receiving instrument, data collecting card is connected in PC machine, the amplifier is connected on same oscillograph with data collecting card, the PC machine is connected with display.

Description

A kind of biological information imaging device and method
Technical field
The present invention relates to technical field of biological information, and in particular to a kind of biological information imaging device and method.
Background technology
One image can include substantial amounts of biological information, no matter in biology or medical research field, research-on-research Person is intended to obtain a directly perceived, clearly static or dynamic image, to analyze cell or organism specific region Feature, state, or even the information such as the expression of specific molecular, distribution.Wherein, Photobiology is imaged since its detecting instrument develops into Ripe, high sensitivity, contrast height, high resolution, imaging is directly perceived, image taking speed is fast and the advantages that lossless detection is widely used. It is seeking the pathogenesis of disease, clinical manifestation, gene lesion, understands corresponding physiology and pathological information, and disease is examined Disconnected and new exploitation of medical procedure etc. has important practice significance and application prospect.
Photobiology is imaged(Optical Imaging)Refer to utilize optical detection means combination optical detection molecule pair Cell or tissue even organism are imaged, to obtain the method for biological information therein.If Photobiology into As being limited to visible ray and near infrared range, the different Photobiology imaging according to detection mode can be divided into fluorescence imaging, life Thing luminescence imaging, photoacoustic imaging, optical fault tomography etc..
Photobiology imaging has very long applicating history, just has some researchers trial from the twentieth century later stage eighties The fluorescent dye of the injection of exogenous agent as a comparison into organism, combined by way of non-intruding in peep realize optics survey Amount, to differentiate the normal and ill region of tumour.Development of the Photobiology imaging dependent on optical molecular probe, its milestone formula Application be in 1994, after Chalfie etc. realizes the successful expression of fluorescin.Fluorescin is a kind of ideal In vivo marker molecule, it is nontoxic, does not influence the function of biology, can voluntarily be synthesized in the cell after transfection, thus is very suitable for living Body marks.Fluorescin is applied in various biological studies rapidly, particularly the research of tumour.The hair of several fluorescins (Osamu Shimomura), Martin Cha Erfei (Martin Charfie) and Qian Yongjian repair in existing person and researcher, lower village (Roger Tsien) therefore obtain the Nobel chemistry Prize of 2008.
Country is clearly by biological industry(Containing medical instrument)Seven Great Wars of development are supported as emphasis during " 12th Five-Year Plan " Slightly one of new industry.Ultrasonic Elasticity Imaging is typical basic medical apparatus key core technology, complies fully with " 12 Strategic of the China on medical device technology and industry during five ".Therefore, quantitative ultrasound elastogram skill is researched and developed Art and corresponding instrument equipment have important social value and economic value, on the one hand realize that liver fibrosis/hepatic sclerosis, mammary gland swell The noninvasive of the soft tissue lesions such as knurl, early stage, Precise Diagnosis, achieve the purpose that early discovery, early treatment, meet China's clinical ultrasound Great demand, improves the general level of the health of China human mortality;On the other hand for promoting China's novel ultrasonic diagnostic techniques and instrument to set The development of standby and high-end color ultrasound key technology is significant, is conducive to change the competition situation of high-end color ultrasound both at home and abroad, is Medical instrument enterprise of China brings more preferable economic benefit.
The content of the invention
In view of the above problems, the present invention provides a kind of biological information imaging device and method, which is based on shearing The ultrasonic Transient elastography system of ripple, the equipment utilization power amplifier, excites low-frequency oscillator using unlike signal, obtains Different degrees of image information, can effectively carry out the comparison of image information, obtain more biological informations, can effectively solve Certainly in background technology the problem of.
To achieve these goals, the technical solution adopted by the present invention is as follows:A kind of biological information imaging device, by low frequency Oscillatory system and ultrasonic image-forming system composition, the low-frequency oscillation system first ultrasonic probe that shakes by low-frequency oscillator and singly form, The low-frequency oscillator is coupled with first ultrasonic probe that singly shakes;The ultrasonic image-forming system include the first signal generator, Secondary signal generator, PC machine and oscillograph, one end of first signal generator are connected on low-frequency oscillator, the other end It is connected in PC machine, one end of the secondary signal generator passes sequentially through power amplifier and protection circuit is connected to low frequency and shakes Swing on device, the other end is also connected in PC machine, and the low-frequency oscillator passes sequentially through attenuator, bandpass filter, amplifier, arteries and veins Rush transmitting/receiving instrument, data collecting card is connected in PC machine, the amplifier and data collecting card are connected to same oscillograph On, the PC machine is connected with display.
Preferably, first ultrasonic probe that singly shakes uses 5MHz, focus 35mm.
In addition the present invention have also been devised a kind of biological information imaging method, include the following steps:
(1)The first signal generator is closed, secondary signal generator is opened, by operating PC machine so that secondary signal generator The single sine wave of a 50Hz is produced, excites low-frequency oscillator to produce the vibration that an amplitude is 1mm by power amplifier, Organization internal is passed to by body surface, excitation soft tissue produces a micro-strain;Using ultrasonic image-forming system, pass through attenuator tune The size of whole collection signal, then the frequency component of other scopes is decayed to by extremely low level by bandpass filter, pass through amplification The signal of collection is amplified by device, then amplified signal is stored in PC by impulse ejection/receiving instrument, data collecting card On machine, and waveform is shown in oscillograph, image display is on display, for signal analysis;
(2)Secondary signal generator is closed, the first signal generator is opened, by operating PC machine so that the first signal generator The single sine wave of a 50Hz is produced, organization internal is directly passed to by body surface, excitation soft tissue produces a micro-strain; The rf echo signal collected is recorded in PC machine by data collecting card using ultrasonic image-forming system, is shown in display Device, for signal analysis;
(3)Compare step(1)And step(2)Obtained imaging data.
Beneficial effects of the present invention:
The present invention is the ultrasonic Transient elastography system based on shearing wave, the equipment utilization power amplifier, using different letters Number excitation low-frequency oscillator, obtains different degrees of image information, can effectively carry out the comparison of image information, obtains more Biological information.
Brief description of the drawings
Fig. 1 is structure diagram of the present invention.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to the accompanying drawings and embodiments, it is right The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and It is not used in the restriction present invention.
Embodiment
With reference to shown in Fig. 1, the present invention provides a kind of biological information imaging device, by low-frequency oscillation system and ultrasonic imaging system System composition, the low-frequency oscillation system first ultrasonic probe that shakes by low-frequency oscillator and singly form, and the low-frequency oscillator is with singly shaking First ultrasonic probe is coupled;First ultrasonic probe that singly shakes uses 5MHz, focus 35mm, the ultrasonic image-forming system bag Include the first signal generator, secondary signal generator, PC machine and oscillograph, one end of first signal generator is connected to low On frequency oscillator, the other end is connected in PC machine, and one end of the secondary signal generator passes sequentially through power amplifier and guarantor Protection circuit is connected on low-frequency oscillator, and the other end is also connected in PC machine, and the low-frequency oscillator passes sequentially through attenuator, band Bandpass filter, amplifier, impulse ejection/receiving instrument, data collecting card are connected in PC machine, the amplifier and data collecting card It is connected on same oscillograph, the PC machine is connected with display.
Its imaging method, includes the following steps:
(1)The first signal generator is closed, secondary signal generator is opened, by operating PC machine so that secondary signal generator The single sine wave of a 50Hz is produced, excites low-frequency oscillator to produce the vibration that an amplitude is 1mm by power amplifier, Organization internal is passed to by body surface, excitation soft tissue produces a micro-strain;Using ultrasonic image-forming system, pass through attenuator tune The size of whole collection signal, then the frequency component of other scopes is decayed to by extremely low level by bandpass filter, pass through amplification The signal of collection is amplified by device, then amplified signal is stored in PC by impulse ejection/receiving instrument, data collecting card On machine, and waveform is shown in oscillograph, image display is on display, for signal analysis;
(2)Secondary signal generator is closed, the first signal generator is opened, by operating PC machine so that the first signal generator The single sine wave of a 50Hz is produced, organization internal is directly passed to by body surface, excitation soft tissue produces a micro-strain; The rf echo signal collected is recorded in PC machine by data collecting card using ultrasonic image-forming system, is shown in display Device, for signal analysis;
(3)Compare step(1)And step(2)Obtained imaging data;
Low-frequency oscillator:Model 4810, place of production Denmark;
Power amplifier:Amplifier research 100A150B, the U.S.;
Data collecting card:GAGE CS8227,100MHz sample rates, 12 bit resolutions;
Ultrasonic elastograph imaging basic principle:Tissue applied inside (including itself) or it is exterior dynamically or statically/ Quasi-static excitation, the physics laws such as Elasticity, biomethanics effect under, tissue will produce one response, such as displacement, should Become, the distribution of speed produces certain change and utilizes ultrasonic imaging method, the skill of combined digital signal processing or Digital Image Processing Art, it is estimated that the corresponding situation of organization internal, so as to directly or indirectly reflect the mechanics categories such as the elasticity modulus of organization internal The difference present invention of property is the ultrasonic Transient elastography system based on shearing wave, the equipment utilization power amplifier, using not With signal excitation low-frequency oscillator, different degrees of image information is obtained, the comparison of image information can be effectively carried out, obtain More biological informations.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention All any modification, equivalent and improvement made within refreshing and principle etc., should all be included in the protection scope of the present invention.

Claims (3)

  1. A kind of 1. biological information imaging device, it is characterised in that it is made of low-frequency oscillation system and ultrasonic image-forming system, it is described low Frequency oscillatory system first ultrasonic probe that shakes by low-frequency oscillator and singly forms, and the low-frequency oscillator is coupled with first ultrasonic probe that singly shakes Together;The ultrasonic image-forming system includes the first signal generator, secondary signal generator, PC machine and oscillograph, and described One end of one signal generator is connected on low-frequency oscillator, and the other end is connected in PC machine, the secondary signal generator One end passes sequentially through power amplifier and protection circuit is connected on low-frequency oscillator, and the other end is also connected in PC machine, described Low-frequency oscillator passes sequentially through attenuator, bandpass filter, amplifier, impulse ejection/receiving instrument, data collecting card and is connected to PC On machine, the amplifier is connected on same oscillograph with data collecting card, and the PC machine is connected with display.
  2. A kind of 2. biological information imaging device according to claim 1, it is characterised in that first ultrasonic probe that singly shakes Using 5MHz, focus 35mm.
  3. 3. a kind of biological information imaging method, it is characterised in that include the following steps:
    (1)The first signal generator is closed, secondary signal generator is opened, by operating PC machine so that secondary signal generator The single sine wave of a 50Hz is produced, excites low-frequency oscillator to produce the vibration that an amplitude is 1mm by power amplifier, Organization internal is passed to by body surface, excitation soft tissue produces a micro-strain;Using ultrasonic image-forming system, pass through attenuator tune The size of whole collection signal, then the frequency component of other scopes is decayed to by extremely low level by bandpass filter, pass through amplification The signal of collection is amplified by device, then amplified signal is stored in PC by impulse ejection/receiving instrument, data collecting card On machine, and waveform is shown in oscillograph, image display is on display, for signal analysis;
    (2)Secondary signal generator is closed, the first signal generator is opened, by operating PC machine so that the first signal generator The single sine wave of a 50Hz is produced, organization internal is directly passed to by body surface, excitation soft tissue produces a micro-strain; The rf echo signal collected is recorded in PC machine by data collecting card using ultrasonic image-forming system, is shown in display Device, for signal analysis;
    (3)Compare step(1)And step(2)Obtained imaging data.
CN201610887484.5A 2016-10-12 2016-10-12 A kind of biological information imaging device and method Pending CN107928703A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610887484.5A CN107928703A (en) 2016-10-12 2016-10-12 A kind of biological information imaging device and method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610887484.5A CN107928703A (en) 2016-10-12 2016-10-12 A kind of biological information imaging device and method

Publications (1)

Publication Number Publication Date
CN107928703A true CN107928703A (en) 2018-04-20

Family

ID=61928186

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610887484.5A Pending CN107928703A (en) 2016-10-12 2016-10-12 A kind of biological information imaging device and method

Country Status (1)

Country Link
CN (1) CN107928703A (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020068870A1 (en) * 2000-07-20 2002-06-06 Alam Sheikh Kaisar Hand held mechanical compression device for inducing tissue strain
CN101869485A (en) * 2010-06-23 2010-10-27 深圳大学 Ultrasonic imaging method and device
CN102283679A (en) * 2011-08-04 2011-12-21 中国科学院深圳先进技术研究院 Ultrasonic imaging system for elasticity measurement and method for measuring elasticity of biological tissue
CN105147327A (en) * 2015-06-12 2015-12-16 深圳大学 Generation method for multi-frequency shear wave
CN105844645A (en) * 2016-03-31 2016-08-10 深圳大学 Instantaneous elasticity imaging code detection method and system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020068870A1 (en) * 2000-07-20 2002-06-06 Alam Sheikh Kaisar Hand held mechanical compression device for inducing tissue strain
CN101869485A (en) * 2010-06-23 2010-10-27 深圳大学 Ultrasonic imaging method and device
CN102283679A (en) * 2011-08-04 2011-12-21 中国科学院深圳先进技术研究院 Ultrasonic imaging system for elasticity measurement and method for measuring elasticity of biological tissue
CN105147327A (en) * 2015-06-12 2015-12-16 深圳大学 Generation method for multi-frequency shear wave
CN105844645A (en) * 2016-03-31 2016-08-10 深圳大学 Instantaneous elasticity imaging code detection method and system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
沈洋等: "超声瞬时弹性成像算法与***设计", 《集成技术》 *

Similar Documents

Publication Publication Date Title
Rus et al. Why are viscosity and nonlinearity bound to make an impact in clinical elastographic diagnosis?
JamesDarian et al. Recent advancements in optical harmonic generation microscopy: Applications and perspectives
CN109716104A (en) The instrument of the orthogonal fluorescence optoacoustic volume projection of total registration for obtaining tissue and its method used
CN1852678A (en) Method and apparatus for examining a substance,particularly tissue, to characterize its type
CN101785663B (en) Opto-acoustic and x-ray detection bimodal digital imaging system and imaging method
Qi et al. Confocal acoustic radiation force optical coherence elastography using a ring ultrasonic transducer
CN102065761B (en) Imaging technique
CN1891162B (en) Ultrasonic diagnostic equipment
Sun et al. Nondestructive evaluation of tissue engineered articular cartilage using time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy
Wang et al. In-vivo imaging of melanoma with simultaneous dual-wavelength acoustic-resolution-based photoacoustic/ultrasound microscopy
Hysi et al. A tutorial in photoacoustic microscopy and tomography signal processing methods
Yang et al. Single-cell photoacoustic microrheology
Krafft et al. Opportunities of optical and spectral technologies in intraoperative histopathology
Ni et al. Assessment of prostate cancer progression using a translational needle photoacoustic sensing probe: Preliminary study with intact human prostates ex-vivo
Yu et al. Simultaneous photoacoustic and ultrasound imaging: A review
Zhang et al. Interstitial photoacoustic spectral analysis: instrumentation and validation
Hall et al. High-frequency ultrasound detection of the temporal evolution of protein cross linking in myocardial tissue
Lee et al. A review on the roles of photoacoustic imaging for conventional and novel clinical diagnostic applications
Zhu et al. Noncontact longitudinal shear wave imaging for the evaluation of heterogeneous porcine brain biomechanical properties using optical coherence elastography
CN103751813B (en) A kind of ultrasonic coupling agent for photoacoustic tomography and preparation method thereof
CN105249933A (en) Photo-acoustic molecule three-dimensional image instrument
CN107928703A (en) A kind of biological information imaging device and method
CN108245189A (en) A kind of dual transducers compensating image method, ultrasonic image-forming system
Holmes OCT technology development: where are we now? A commercial perspective
CN101889862B (en) Three-dimensional scanning body electrographic apparatus used for detecting human body functions and detection method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180420

RJ01 Rejection of invention patent application after publication