CN107890436A - A kind of cosmetics for whitening antioxidation - Google Patents
A kind of cosmetics for whitening antioxidation Download PDFInfo
- Publication number
- CN107890436A CN107890436A CN201711256117.6A CN201711256117A CN107890436A CN 107890436 A CN107890436 A CN 107890436A CN 201711256117 A CN201711256117 A CN 201711256117A CN 107890436 A CN107890436 A CN 107890436A
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- Prior art keywords
- whitening
- component
- whitening antioxidation
- cosmetics
- antioxidation
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of cosmetics for whitening antioxidation, it is related to cosmetic field.The whitening antioxidation cosmetic product include the weight/mass percentage composition of component and each component：Atoleine 21 ~ 29%, olive oil 27 ~ 33%, microcrystalline wax 0.5 ~ 2%, vaseline 1 ~ 3%, anhydrous sorbitol list olein 1 ~ 5%, glycerine 1.5 ~ 3.5%, whitening antioxidation agent 2.5 ~ 10%, dimethyl sulfoxide (DMSO) 3 ~ 4%, essence 3 ~ 10 ‰, surplus is deionized water.Wherein whitening antioxidation agent includes genistein Phenylpiperazine derivatives 50 ~ 94% and pea protein isolated peptides 6 ~ 50%.Cosmetics of the present invention have whitening, oxidation resistant effect simultaneously.
Description
Technical field
The invention discloses a kind of cosmetics for whitening antioxidation, belong to cosmetic field.
Technical background
Environmental pollution, ultraviolet, stress, electromagnetic radiation, fume pollution, age increase, and skin can all occurred each
The problem of kind various kinds, skin pigmentation disorder, melanin pigmentation increase, accelerate skin aging, make the intense darkness without light pool of skin, so that
Influence physical and mental health and the human communication of people.
Traditional skin-whitening agents（Hydrogen peroxide, compound containing mercury）Have to skin compared with strong cytotoxicity, corrosivity and mistake
Quick property etc. so that traditional whitening agent has larger toxicity and danger, has clearly been disabled in multiple national hygienic practices.And
The primary standard of skin-whitening agents is exactly should have non-stimulated and higher security nontoxic to skin.Further, since melanin
Biosynthesis pathway be not that single therefore single whitening composition is extremely difficult to preferable whitening effect.And in the market ratio
More typical whitening agent, is single tyrosinase activity inhibitor, such as Cu2+Chelating agent kojic acid, edta edta
, benzohydroxamic acid and tropolone, this whitening agent long-term use can not only cause to stimulate to skin, while its whitening effect
It is more general.
The content of the invention
To solve the deficiencies in the prior art, the invention provides a kind of while have whitening and the cosmetic of antioxidation
Product.
To reach while having whitening and oxidation resistant effect, it is a feature of the present invention that including following components and each group
Point mass percent is respectively：Atoleine 21 ~ 29%, olive oil 27 ~ 33%, microcrystalline wax 0.5 ~ 2%, vaseline 1 ~ 3%, dehydration
Sorbierite list olein 1 ~ 5%, glycerine 1.5 ~ 3.5%, whitening antioxidation agent 2.5 ~ 10%, dimethyl sulfoxide (DMSO) 3 ~ 4%, essence 3 ~
10 ‰, surplus is deionized water.
Wherein, described whitening antioxidation agent and its mass percent be, genistein Phenylpiperazine derivatives 50 ~ 94%,
Pea protein isolated peptides 6 ~ 50%.
Cosmetics of the present invention for whitening antioxidation include following preparation process.
（1）Each component is weighed respectively according to said ratio.
（2）Atoleine, olive oil, microcrystalline wax, vaseline, anhydrous sorbitol list olein, glycerine are heated to 75
DEG C dissolving, obtain component 1.
（3）By essence deionized water dissolving, component 2 is obtained.
（4）Whitening antioxidation agent deionized water, dimethyl sulfoxide (DMSO) and anhydrous sorbitol list olein are dissolved（Dimethyl
The ratio of sulfoxide and anhydrous sorbitol list olein is 1:1）, obtain component 3.
（5）Homogeneous after component 1,2,3 is mixed, you can obtain the cosmetic of the present invention with whitening antioxidation effect
Product.
Genistein Phenylpiperazine derivatives molecular formula of the present invention is C28H28N2O5, molecular weight 472.52, it
It is a kind of whitening agent obtained by genistein and 1- (2,4)-dimethylphenylpiperazinium through chemical synthesis.Research shows that it is right
Tyrosinase has significant inhibition, and when concentration is 4% or so, inhibiting rate is up to 23%, while can promote superoxides discrimination
Change the activity of enzyme, promotion rate is up to 47% when concentration is 4% or so.Genistein Phenylpiperazine derivatives are on the one hand by suppressing junket ammonia
Sour enzyme suppresses the generation of black, on the other hand by promoting superoxide dismutase, enhance skin oxidation resistance and
Remove the ability of the harmful substances such as ROS, it is suppressed that the oxidation of lipid so that lipid can not generate MDA, so as to inhibit protein
It is cross-linked to form pigment.
Pea protein isolated peptides of the present invention, its preparation technology is Fed Protein Powder of Pea Insteal, to add neutral proteinase, in machine
60 DEG C of temperature of cylinder, screw speed are 170 r/min, and nib aperture is extruded under conditions of being 12 mm, and extrudate is through pawpaw
Protease hydrolyzed, enzymolysis liquid is separating obtained through 1 KDa bag filters, and molecular weight is about between 200 ~ 800 Da.It can be notable
Removing ultra-oxygen anion free radical, clearance rate has efficient antioxidation, can slow down skin aging up to 64%.
Research shows that single whitening composition is extremely difficult to preferable whitening effect, generally requires by two or more
Whitening agent is compounded, or whitening agent and antioxidant are compounded, so as to reach more preferable whitening antioxidation effect.Contaminated in the present invention
There is complex role, pea protein isolated peptides and genistein between material lignin Phenylpiperazine derivatives and pea protein isolated peptides
The complex role of Phenylpiperazine derivatives enhances the antioxidation of cosmetics so that cosmetics of the present invention, is having
There is oxidation resistant effect again while having efficient whitening function, therefore available for the cosmetics in whitening antioxidation field.
Beneficial effects of the present invention：Natural plant extracts are combined for cosmetics by the present invention with synthetics,
So that cosmetics have whitening, oxidation resistant effect simultaneously, make skin glossy, flexible.
Embodiment
The present invention is further described by the following examples, but the protection that these embodiments are not intended to limit the invention
Scope and the scope of application.
Embodiment 1
The component proportion and each component mass percent of embodiment 1 be respectively：Atoleine 25%, olive oil 30%, microcrystalline wax
1%, vaseline 2%, anhydrous sorbitol list olein 3%, glycerine 2.5%, whitening antioxidation agent 5.5%, dimethyl sulfoxide (DMSO) 3%, strawberry
Essence 7 ‰, surplus are deionized water.Wherein whitening antioxidant is genistein Phenylpiperazine derivatives 73%, pea protein point
From peptide 27%.
Step of preparation process is as follows.
（1）Each component is weighed respectively according to said ratio.
（2）Atoleine, olive oil, microcrystalline wax, vaseline, anhydrous sorbitol list olein, glycerine are heated to 75
DEG C dissolving, obtain component 1.
（3）By essence deionized water dissolving, component 2 is obtained.
（4）Skin-whitening antioxidant deionized water, dimethyl sulfoxide (DMSO) and anhydrous sorbitol list olein are dissolved molten
Solution（The ratio of dimethyl sulfoxide (DMSO) and anhydrous sorbitol list olein is 1:1）, obtain component 3.
（5）Homogeneous after component 1,2,3 is mixed, you can obtain the cosmetic of the present invention with whitening antioxidation effect
Product.
Embodiment 2
The component proportion and each component mass percent of embodiment 2 be respectively：Atoleine 21%, olive oil 33%, microcrystalline wax
2%, vaseline 3%, anhydrous sorbitol list olein 1%, glycerine 3.5%, whitening antioxidation agent 4%, dimethyl sulfoxide (DMSO) 3%, jasmine perfume
Essence 3 ‰, surplus is deionized water.Wherein whitening antioxidant is genistein Phenylpiperazine derivatives 50%, pea protein separation
Peptide 50%.
Preparation technology and step are the same as embodiment 1.
Embodiment 3
The component proportion and each component mass percent of embodiment 3 be respectively：Atoleine 29%, olive oil 27%, microcrystalline wax
0.5%, vaseline 1%, anhydrous sorbitol list olein 5%, glycerine 1.5%, whitening antioxidation agent 9.5%, dimethyl sulfoxide (DMSO) 4%, water
Honey peach essence 10 ‰, surplus are deionized water.Wherein whitening antioxidant is genistein Phenylpiperazine derivatives 84%, pea egg
White isolated peptides 16%.
Preparation technology and step are the same as embodiment 1.
Claims (6)
1. a kind of cosmetics for whitening antioxidation, it is characterised in that the weight/mass percentage composition of each component is：Atoleine 21
~ 29%, olive oil 27 ~ 33%, microcrystalline wax 0.5 ~ 2%, vaseline 1 ~ 3%, anhydrous sorbitol list olein 1 ~ 5%, glycerine 1.5 ~
3.5%, whitening antioxidation agent 2.5 ~ 10%, dimethyl sulfoxide (DMSO) 3 ~ 4%, essence 3 ~ 10 ‰, surplus is deionized water.
2. a kind of cosmetics for whitening antioxidation, it is characterised in that including following preparation process：
（1）Each component is weighed respectively according to said ratio；
（2）By atoleine, olive oil, microcrystalline wax, vaseline, anhydrous sorbitol list olein, glycerine be heated to 75 DEG C it is molten
Solution, obtains component 1；
（3）By essence deionized water dissolving, component 2 is obtained；
（4）Whitening antioxidation agent deionized water, dimethyl sulfoxide (DMSO) and anhydrous sorbitol list olein are dissolved（Dimethyl sulfoxide (DMSO)
Ratio with anhydrous sorbitol list olein is 1:1）, obtain component 3；
（5）Homogeneous after component 1,2,3 is mixed, you can obtain the cosmetics of the present invention with whitening antioxidation effect.
A kind of 3. cosmetics for whitening antioxidation as claimed in claim 1, it is characterised in that described whitening antioxidation
Agent includes genistein Phenylpiperazine derivatives and pea protein isolated peptides.
A kind of 4. cosmetics for whitening antioxidation as claimed in claim 1, it is characterised in that described whitening antioxidation
The weight/mass percentage composition of agent each component is respectively, and genistein Phenylpiperazine derivatives 50 ~ 94%, pea protein isolated peptides 6 ~
50%。
5. whitening antioxidation agent as claimed in claim 4, it is characterised in that described pea protein isolated peptides preparation technology
For：Fed Protein Powder of Pea Insteal, add neutral proteinase, in 60 DEG C of barrel zone temperature, screw speed is 170 r/min, and nib aperture is 12
Extruded under conditions of mm, extrudate is separating obtained through 1 KDa bag filters through papain enzymolysis, enzymolysis liquid.
6. whitening antioxidation agent as claimed in claim 6, it is characterised in that described pea protein isolated peptides, its molecular weight
It is distributed in mostly between 200 ~ 800 Da.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711256117.6A CN107890436A (en) | 2017-12-04 | 2017-12-04 | A kind of cosmetics for whitening antioxidation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711256117.6A CN107890436A (en) | 2017-12-04 | 2017-12-04 | A kind of cosmetics for whitening antioxidation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107890436A true CN107890436A (en) | 2018-04-10 |
Family
ID=61807230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711256117.6A Withdrawn CN107890436A (en) | 2017-12-04 | 2017-12-04 | A kind of cosmetics for whitening antioxidation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107890436A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109055466A (en) * | 2018-07-30 | 2018-12-21 | 山东理工大学 | A kind of preparation method of pea peptide and its application in whitening field |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006470A (en) * | 2011-09-20 | 2013-04-03 | 姜竹芬 | Anhydrous paste type cleaning cream |
| CN103565725A (en) * | 2013-11-03 | 2014-02-12 | 上海方木精细化工有限公司 | Lucid ganoderma vanishing cream |
| CN103655286A (en) * | 2013-11-20 | 2014-03-26 | 青岛晨讯通商贸有限公司 | Skin hydrating moisture veil |
| CN103800254A (en) * | 2014-03-14 | 2014-05-21 | 南京中医药大学 | Application of solidago canadensis to preparation of whitening and anti-aging cosmetic |
| CN106074204A (en) * | 2016-04-18 | 2016-11-09 | 山东理工大学 | The application in whitening field of a kind of genistein derivant |
| CN106260498A (en) * | 2016-08-08 | 2017-01-04 | 山东理工大学 | The manufacture method of a kind of Semen Pisi sativi protein peptide and application |
-
2017
- 2017-12-04 CN CN201711256117.6A patent/CN107890436A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006470A (en) * | 2011-09-20 | 2013-04-03 | 姜竹芬 | Anhydrous paste type cleaning cream |
| CN103565725A (en) * | 2013-11-03 | 2014-02-12 | 上海方木精细化工有限公司 | Lucid ganoderma vanishing cream |
| CN103655286A (en) * | 2013-11-20 | 2014-03-26 | 青岛晨讯通商贸有限公司 | Skin hydrating moisture veil |
| CN103800254A (en) * | 2014-03-14 | 2014-05-21 | 南京中医药大学 | Application of solidago canadensis to preparation of whitening and anti-aging cosmetic |
| CN106074204A (en) * | 2016-04-18 | 2016-11-09 | 山东理工大学 | The application in whitening field of a kind of genistein derivant |
| CN106260498A (en) * | 2016-08-08 | 2017-01-04 | 山东理工大学 | The manufacture method of a kind of Semen Pisi sativi protein peptide and application |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109055466A (en) * | 2018-07-30 | 2018-12-21 | 山东理工大学 | A kind of preparation method of pea peptide and its application in whitening field |
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| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180410 |
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| WW01 | Invention patent application withdrawn after publication |