CN107875040A - Anti-acne compound essential oil and preparation method thereof - Google Patents

Anti-acne compound essential oil and preparation method thereof Download PDF

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Publication number
CN107875040A
CN107875040A CN201711399607.1A CN201711399607A CN107875040A CN 107875040 A CN107875040 A CN 107875040A CN 201711399607 A CN201711399607 A CN 201711399607A CN 107875040 A CN107875040 A CN 107875040A
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essential oil
oil
parts
compound essential
acne
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CN107875040B (en
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徐公滨
徐新清
王清路
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Guangzhou Biying Cosmetics Co ltd
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Qilu Medical University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/733Alginic acid; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/008Preparations for oily skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to skincare product technical field, and in particular to a kind of anti-acne compound essential oil and preparation method thereof.The anti-acne compound essential oil is made up of 5 15wt.% compound essential oils, 85 95wt.% base oils, and compound essential oil is modified using modifying agent, adds the hydrophily and lipophile of compound essential oil;And then anti-acne compound essential oil is preferably dissolved into skin.Described modifying agent is that sodium alginate first carries out first esterification with ethanedioic acid, then carries out esterification again with glycerine and obtain.The anti-acne compound essential oil that the present invention obtains can stimulate cell, make regeneration, have anti-acne, oil-control, moisture-keeping function and can nurse one's health protection skin, also have good result to doing quick inflammation skin;Also have simultaneously and eliminate oedema, nourish, prevent skin lipids from aoxidizing, prevention epidermal tissue degenerates, and prevents skin ageing, convergence is with promoting wound to scab function.Preparation method of the present invention is simple, easily operated.

Description

Anti-acne compound essential oil and preparation method thereof
Technical field
The invention belongs to skincare product technical field, and in particular to a kind of anti-acne compound essential oil and preparation method thereof.
Background technology
Essential oil can enter blood circulation by Cutaneous permeation, can effectively nurse one's health body, reach the effect such as releive, purify. Its essence can keep off infection, to Anti-bacterium, anti-inflammation, anti-spasm, promote cell metabolism and cytothesis function.Essential oil It is in the flower from plant, leaf, stem, root or fruit, is refined by steam distillation, extrusion, cold-maceration or solvent extraction method The volatile flavor of extraction.Essential oil has lipophilicity, it is easy to is dissolved in grease, because the strand of essential oil generally compares Short, this causes them easily to permeate in skin, and enters in vivo by the capillary enriched under subcutaneous fat.Essential oil be by The molecule of some very littles is formed, these high volatile substances, can enter body by nasal membrane tissue resorption, message is directly sent To brain, by the limbic system of brain, mood and the physiological function of body are adjusted.So in aromatotherapy, essential oil can be strong Metaplasia is managed and the function of psychology.As German chamomile essential oil has adjustment skin function well, nourishes rough skin cell, reparation damage Hinder skin, and with the positive effect such as allay excitement, releive, some compositions also have the function of regulation human endocrine in essential oil.
Compound essential oil is to be formed by various plants essential oil according to its different property allotment, and it is potential that it is mainly used in human body Focus etc. improvement.According to the specific symptom of human body, with the control of appropriate folk prescription essential oil and substrate oil and dosage, do Certain compound collocation can be only achieved expected effect.Compound essential oil, which refers to, have been matched, and is available for the formula essential oil used immediately, warp After combination allotment, finished product is made, use is more convenient.
Chinese patent CN106266685A discloses a kind of compound essential oil and preparation method thereof.The compound essential oil mixes comprising essential oil Liquid is closed, in parts by weight, the essential oil mixed liquor includes following component:Peppermint oil 5-25 parts, borneol 1-10 parts, eucalyptus oil 1-10 Part, citronella oil 10-30 parts, lavender oil 10-30 parts, wormwood oil 10-25 parts, tea oil 1-30 parts.Compound essence described in the patent Oil, the volatile oil come from a variety of extracted form natural plants is as raw material, without any dangerous chemical composition, by medicine Combined with the effects of both plant Rose Absolutes, effect diversification, fragrance it is pleasant, there is mosquito-expelling and antipruritic, refrigerant detumescence medicine While effect, anxiety can also be alleviated, refreshed the mind, safely and effectively, realize the low dose of, effect of large effect.But the patent The composition of compound essential oil is not modified, its essential oil does not have hydrophily.
Modern society's life rhythm is nervous, and work busy, stress long term accumulation, inadequate, endocrine disturbance of sleeping, Ultraviolet radiation and environmental pollution etc. cause various skin problems:Dry skin, aging, dark yellow, color spot, small pox, allergy etc..Cuo Sore is also known as whelk, acne, is a kind of chronic inflammatory skin of pilosebaceous unit, is apt to occur in teenager, the course of disease compared with It is long.The factors such as the generation of acne mainly blocks with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction are close Cut is closed.Clinical manifestation is with the characteristics of being apt to occur in the polymorphy skin lesions such as facial acne, papule, warts, tubercle.
Therefore, a kind of convergence of research and skin of releiving are needed badly, effectively control skin water and oil balance anti-acne compound essential oil and Its preparation method.
The content of the invention
It is an object of the invention to provide one kind convergence and skin of releiving, and effectively controls the anti-acne compound of skin water and oil balance smart Oil, present invention simultaneously provides its preparation method.
Anti-acne compound essential oil of the present invention:In terms of anti-acne compound essential oil gross mass, by 5-15wt.% compound essential oils, 85-95wt.% base oils are made;
Described compound essential oil is made up of the component of following parts by weight:German chamomile essential oil 40-60 parts, Rizhao Green Tea Essential oil 20-30 parts, Rosa Damascana 10-20 parts, aloe 10-30 parts, cypress essential oil 5-10 parts, modifying agent 5-10 parts;Described Modifying agent is that sodium alginate first carries out first esterification with ethanedioic acid, then carries out esterification again with glycerine and obtain;
Preferably, German chamomile essential oil 50-60 parts, Rizhao Green Tea essential oil 25-30 parts, Rosa Damascana 15-20 parts, aloe Oily 20-30 parts, cypress essential oil 8-10 parts, modifying agent 8-10 parts;
It is further preferable that German 55 parts of chamomile essential oil, 28 parts of Rizhao Green Tea essential oil, 15 parts of Rosa Damascana, aloe 25 Part, 8 parts of cypress essential oil, 10 parts of modifying agent.
Described base oil is made up of the component of following parts by weight:Wheat base bud oil 4-6 parts, Sweet Almond Oil or hazelnut oil Or grape-kernel oil 2-3 parts;Preferably, 5 parts of wheat base bud oil, Sweet Almond Oil or 2.5 parts of hazelnut oil or grape-kernel oil.
The preparation process of described modifying agent is:Aqueous oxalic acid is added drop-wise in sodium alginate aqueous solution and carried out for the first time Esterification, reaction finish, then glycerine is added dropwise thereto and carries out esterification again, obtain modifying agent.
Wherein:
Described sodium alginate aqueous solution, aqueous oxalic acid, the mass ratio of glycerine are 1:1-1.5:0.1-0.15.
Described first esterification reaction temperature is 50-60 DEG C, and first reaction time of esterification is 1-1.5h.
Described esterification reaction temperature again is 70-80 DEG C, and reaction time of esterification is 1-1.5h again.
The concentration of described aqueous oxalic acid is 0.2-0.5wt.%, and the concentration of sodium alginate aqueous solution is 8- 12wt.%.
The preparation method of anti-acne compound essential oil of the present invention is:Aqueous oxalic acid is first added drop-wise to sodium alginate water First esterification is carried out in solution, reaction finishes, then glycerine is added dropwise thereto and carries out esterification again, is modified Agent, then modifying agent is added to the mixing of German chamomile essential oil, Rizhao Green Tea essential oil, Rosa Damascana, aloe, cypress essential oil In thing, compound essential oil is obtained;Then wheat base bud oil is well mixed with Sweet Almond Oil or hazelnut oil or grape-kernel oil, obtains base Plinth oil;Finally compound essential oil is added in base oil and mixed, is stirred, obtains anti-acne compound essential oil.
German chamomile essential oil is extracted from German chamomile.German chamomile is also known as blue camomile, german chamomile, Hungary Camomile and single-lobe camomile, be a kind of light blue liquid, have to dryness, sensitive skin it is extraordinary pacify calm effect, because its tool The effect of releiving, can arrange in pairs or groups many both effectiveness strong essential oils and skin care item use, for alleviating caused by skin improvement not It is suitable.
Rizhao Green Tea extraction of essential oil particularly outstanding spring tea of quality from green tea, growing environment light application time length are warm round the clock Poor big, production period is slow, thus beneficial to the savings of material in tealeaves.Rizhao Green Tea essential oil has the antimicrobial work of All Pure Nature Property, biocidal efficacies, antibacterial activity, nonirritant, excellent Cutaneous permeation effect and uniqueness armaticity the advantages that, and promote flesh The effect of skin regenerates is outstanding, has special efficacy to whelk, scar, impetigo, incised wound.
Rosa Damascana is the basic medicinal ingredient of rose, and it can stimulate the immune and nervous system with landman, have simultaneously Help improve the secretion of incretory, remove organ sclerosis, repair cell.Rosa Damascana can decompose pigment, accelerate nutrient and water The balance divided, strengthens cytotoxic discharge, so as to reach to the integrally-regulated of skin internal and external environment, is suitable for skin care guarantor Support, there is anti-ageing, wrinkle resistant and moisture-keeping efficacy, all there is conditioning curative effect well to various skin.
Aloe, be the crude vegetal based on C12~C14 aliphatic acid, comprising aloe intrinsic 169 kinds beneficial into Point, nutrient can be helped to penetrate into skin gleditsia sinensis, there is strength cleaning, anti-inflammatory, detumescence, bacteria growing inhibiting, antipruritic, analgesic And other effects.
Cypress essential oil be with Fresh leaves and cone distillation form, can restrain and skin of releiving, regulation fat secretion, tighten Pore, it is the optimal selection of moisturizing.
Wheat-germ oil, it is a kind of grain germ oil using wheat malt as waste, rich in vitamin E, linoleic acid, Asia Numb sour, sweet eight carbon alcohol and a variety of physiologically active components, have very high nutritive value.Particularly content of vitamin E is vegetable oil Hat, be acknowledged as a kind of functional grease for having much nutrition health-care functions, there is following effect:Adjust endocrine, fat-reducing, Prevent color spot, blackspot and pigmentation;It is anti-oxidant, promote moisture-retention function of skin, skin is moistened, anti-aging;Promote new old Metabolism and skin renewal, crease-resistant, wrinkle resistant, anti-skin aging, eliminate scar;Regulating blood lipoid, softening blood vessel, prevention of arterial hardening, Hypertension, apoplexy etc..
Sweet Almond Oil, belong to neutral base oil, there is good skin-friendly.Squeezed by apricot fruit and obtained, to pimples Skin has opsonic action, moisten, softening skin quality function it is good, all can mutually be reconciled with any vegetable oil, be most widely used One of base oil.
Hazelnut oil, there is slightly convergence, blending property, can quickly absorb;Oily, combination and tune can be made The perverse base oil of powder is managed, can be reconciled and taught skin, helps skin to keep stable and elastic, can be 100% as base oil use.
Grape-kernel oil, composition are vitamin B1, B3, B5, C, F, chlorophyll, trace quantity mineral substance element, essential fatty acid, fruit Sugar, glucose, mineral matter, potassium, phosphorus, calcium, magnesium and vine polyphenol;Its penetration is strong, can be used in facial massage and treatment, Especially delicate and sensitive skin, oiliness, dark sore, acne-prone skin.VitaminF, mineral matter, the protein contained, can strengthen flesh The moistening effect of skin, while can moisten, soft skin, the salubrious non-greasy of quality, easily absorbed by skin.
Beneficial effects of the present invention are as follows:
The present invention is first modified to compound essential oil, and sodium alginate is first reacted with ethanedioic acid, then is reacted with glycerine, system Obtain modifying agent.A carboxyl in ethanedioic acid first forms ester bond with a hydroxyl in sodium alginate, another in ethanedioic acid Carboxyl also forms ester bond with a hydroxyl in glycerine, and sodium alginate is formed with second two with there remains hydroxyl in glycerine Acid is bridge, both contains ester bond, and the macro-radical containing hydroxyl.The hydroxyl and glycerine of sodium alginate in macro-radical Hydroxyl be respectively provided with hydrophily, the ester bond contained in macro-radical has lipophile, modifying agent is added in compound essential oil, The hydrophily and lipophile of compound essential oil are added, and then anti-acne compound essential oil is preferably entered in skin, meanwhile, it is capable to Moisture is pinned, increases moistening effect.
The anti-acne compound essential oil that the present invention obtains can stimulate cell, make regeneration, have anti-acne, oil-control, moisture-keeping function And protection skin can be nursed one's health, also there is good result to allergy inflammation skin;Also have simultaneously and eliminate oedema, nourish, prevent skin Lipid oxidation, prevention epidermal tissue degenerate, and prevent skin ageing, convergence is with promoting wound to scab function.Preparation method of the present invention Simply, it is easily operated.
Embodiment
The present invention is described further with reference to embodiments.
Embodiment 1
Described anti-acne compound essential oil:In terms of anti-acne compound essential oil gross mass, by 8.81wt.% compound essential oils, 91.19wt.% base oils are made;
Wherein:
Compound essential oil is made up of the component of following quality:German chamomile essential oil 10g, Rizhao Green Tea essential oil 5g, rhodamine toner Oily 3g, aloe 3g, cypress essential oil 2g, modifying agent 6g;
Base oil is made up of the component of following quality:Wheat base bud oil 200g, Sweet Almond Oil 100g;
The preparation process of modifying agent is as follows:
First 0.5wt.% aqueous oxalic acid is added drop-wise in 10wt.% sodium alginate aqueous solution, entered at 55 DEG C The first esterification 1.5h of row, reaction is finished, then glycerine is added dropwise thereto, and esterification 1.5h again is carried out at 75 DEG C, Obtain modifying agent.Wherein sodium alginate aqueous solution, aqueous oxalic acid, the mass ratio of glycerine are 1:1.2:0.15.
The preparation method of described anti-acne compound essential oil is:Modifying agent is added to German chamomile essential oil, Rizhao Green Tea Essential oil, Rosa Damascana, aloe, cypress essential oil mixture in, obtain compound essential oil;Then by wheat base bud oil and dessert almond Oil is well mixed, obtains base oil;Finally compound essential oil is added in base oil and mixed, is stirred, obtains anti-acne compound Essential oil.
Embodiment 2
Described anti-acne compound essential oil:In terms of anti-acne compound essential oil gross mass, by 12.54wt.% compound essential oils, 87.46wt.% base oils are made;
Wherein:
Compound essential oil is made up of the component of following quality:German chamomile essential oil 15g, Rizhao Green Tea essential oil 10g, rhodamine toner Oily 3g, aloe 6g, cypress essential oil 4g, modifying agent 5g;
Base oil is made up of the component of following quality:Wheat base bud oil 200g, hazelnut oil 100g;
The preparation process of modifying agent is as follows:
First 0.3wt.% aqueous oxalic acid is added drop-wise in 8wt.% sodium alginate aqueous solution, carried out at 60 DEG C First esterification 1h, reaction is finished, then glycerine is added dropwise thereto, and esterification 1h again is carried out at 80 DEG C, is changed Property agent.Wherein sodium alginate aqueous solution, aqueous oxalic acid, the mass ratio of glycerine are 1:1.5:0.1.
The preparation method of described anti-acne compound essential oil is the same as embodiment 1.
Embodiment 3
Described anti-acne compound essential oil:In terms of anti-acne compound essential oil gross mass, by 14.77wt.% compound essential oils, 85.23wt.% base oils are made;
Wherein:
Compound essential oil is made up of the component of following quality:German chamomile essential oil 20g, Rizhao Green Tea essential oil 10g, rhodamine toner Oily 3g, aloe 10g, cypress essential oil 5g, modifying agent 4g;
Base oil is made up of the component of following quality:Wheat base bud oil 200g, grape-kernel oil 100g;
The preparation process of modifying agent is as follows:
First 0.4wt.% aqueous oxalic acid is added drop-wise in 12wt.% sodium alginate aqueous solution, entered at 50 DEG C The first esterification 1.5h of row, reaction is finished, then glycerine is added dropwise thereto, and esterification 1.5h again is carried out at 70 DEG C, Obtain modifying agent.Wherein sodium alginate aqueous solution, aqueous oxalic acid, the mass ratio of glycerine are 1:1.2:0.12.
The preparation method of described anti-acne compound essential oil is the same as embodiment 1.
Comparative example 1
Modifying agent is not added in compound essential oil, remaining step is the same as embodiment 1.
The anti-acne compound essential oil that embodiment 1-3 and comparative example 1 are obtained is used for the patient for having grown acne on the face, as a result such as table 1。
Table 1 applies result
Group Number of cases It is effective Effectively To no effect Total effective rate
Embodiment 1 25 20 5 0 100%
Embodiment 2 25 22 3 0 100%
Embodiment 3 25 21 4 0 100%
Comparative example 1 25 15 4 6 76%
From table 1 it follows that anti-acne compound essential oil curative effect produced by the present invention is excellent, due to adding for modifying agent of the present invention Enter, have adjusted the water and oil balance of skin, compared to comparative example 1, embodiment 1-3 total effective rate reaches 100%.
Above-mentioned test is completed in biomedical engineering technology key lab of colleges and universities of Shandong Province.

Claims (10)

  1. A kind of 1. anti-acne compound essential oil, it is characterised in that:In terms of anti-acne compound essential oil gross mass, by 5-15wt.% compound essential oils, 85-95wt.% base oils are made;
    Described compound essential oil is made up of the component of following parts by weight:German chamomile essential oil 40-60 parts, Rizhao Green Tea essential oil 20-30 parts, Rosa Damascana 10-20 parts, aloe 10-30 parts, cypress essential oil 5-10 parts, modifying agent 5-10 parts;Described modification Agent is that sodium alginate first carries out first esterification with ethanedioic acid, then carries out esterification again with glycerine and obtain;
    Described base oil is made up of the component of following parts by weight:Wheat base bud oil 4-6 parts, Sweet Almond Oil or hazelnut oil or Portugal Grape seed oil 2-3 parts.
  2. 2. anti-acne compound essential oil according to claim 1, it is characterised in that:Described compound essential oil is by following parts by weight Component be made:German chamomile essential oil 50-60 parts, Rizhao Green Tea essential oil 25-30 parts, Rosa Damascana 15-20 parts, aloe 20-30 parts, cypress essential oil 8-10 parts, modifying agent 8-10 parts.
  3. 3. anti-acne compound essential oil according to claim 2, it is characterised in that:Described compound essential oil is by following parts by weight Component be made:German 55 parts of chamomile essential oil, 28 parts of Rizhao Green Tea essential oil, 15 parts of Rosa Damascana, 25 parts of aloe, cypress essence Oily 8 parts, 10 parts of modifying agent.
  4. 4. anti-acne compound essential oil according to claim 1, it is characterised in that:Described base oil is by following parts by weight Component is made:5 parts of wheat base bud oil, Sweet Almond Oil or 2.5 parts of hazelnut oil or grape-kernel oil.
  5. 5. anti-acne compound essential oil according to claim 1, it is characterised in that:The preparation process of described modifying agent is as follows: Aqueous oxalic acid is added drop-wise in sodium alginate aqueous solution and carries out first esterification, reaction finishes, then third is added dropwise thereto Triol carries out esterification again, obtains modifying agent.
  6. 6. anti-acne compound essential oil according to claim 5, it is characterised in that:Described sodium alginate aqueous solution, ethanedioic acid The aqueous solution, the mass ratio of glycerine are 1:1-1.5:0.1-0.15.
  7. 7. anti-acne compound essential oil according to claim 5, it is characterised in that:Described first esterification reaction temperature is 50- 60 DEG C, first reaction time of esterification is 1-1.5h.
  8. 8. anti-acne compound essential oil according to claim 5, it is characterised in that:Described esterification reaction temperature again is 70- 80 DEG C, reaction time of esterification is 1-1.5h again.
  9. 9. anti-acne compound essential oil according to claim 5, it is characterised in that:The concentration of described aqueous oxalic acid is 0.2-0.5wt.%, the concentration of sodium alginate aqueous solution is 8-12wt.%.
  10. A kind of 10. preparation method of the anti-acne compound essential oil described in claim 1, it is characterised in that:First by aqueous oxalic acid It is added drop-wise in sodium alginate aqueous solution and carries out first esterification, reaction finishes, then glycerine is added dropwise thereto and carries out ester again Change reaction, obtain modifying agent, then modifying agent is added to German chamomile essential oil, Rizhao Green Tea essential oil, Rosa Damascana, aloe In oily, cypress essential oil mixture, compound essential oil is obtained;Then by wheat base bud oil and Sweet Almond Oil or hazelnut oil or grape pip Oil is well mixed, obtains base oil;Finally compound essential oil is added in base oil and mixed, is stirred, obtains anti-acne compound Essential oil.
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CN110200857A (en) * 2019-07-08 2019-09-06 江苏康地源生态农场有限公司 It is a kind of with anti-oxidant, delaying skin aging effect compound wormwood essential oil
CN110302127A (en) * 2019-08-08 2019-10-08 湖北瑞晟生物有限责任公司 A kind of preparation method of heal-care essential oil
CN112617018A (en) * 2020-12-17 2021-04-09 福建傲农生物科技集团股份有限公司 Composition for resisting diseases and promoting growth and application thereof
CN112755083A (en) * 2021-01-22 2021-05-07 广州顺倬能源科技有限公司 Emu camphor essential oil for promoting skin repair and preparation method thereof
CN113712836A (en) * 2020-12-30 2021-11-30 深圳市巴斯星科技有限公司 Anti-inflammatory acne-removing skin care composition and preparation method and using method thereof
CN114469822A (en) * 2020-10-23 2022-05-13 广州樱奈儿化妆品有限公司 Acne-removing repairing cream and preparation method thereof

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