CN107854562A - A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription - Google Patents

A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription Download PDF

Info

Publication number
CN107854562A
CN107854562A CN201711146607.0A CN201711146607A CN107854562A CN 107854562 A CN107854562 A CN 107854562A CN 201711146607 A CN201711146607 A CN 201711146607A CN 107854562 A CN107854562 A CN 107854562A
Authority
CN
China
Prior art keywords
parts
component
kidney
chinese medicine
traditional chinese
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711146607.0A
Other languages
Chinese (zh)
Inventor
廖梅生
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHANGSHA BOTAI BIOLOGICAL SCI-TECH Co Ltd
Original Assignee
CHANGSHA BOTAI BIOLOGICAL SCI-TECH Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHANGSHA BOTAI BIOLOGICAL SCI-TECH Co Ltd filed Critical CHANGSHA BOTAI BIOLOGICAL SCI-TECH Co Ltd
Priority to CN201711146607.0A priority Critical patent/CN107854562A/en
Publication of CN107854562A publication Critical patent/CN107854562A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02Algae
    • A61K36/03Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/40Cornaceae (Dogwood family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/43Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/52Juglandaceae (Walnut family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/64Orobanchaceae (Broom-rape family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, including component A, B component, component A to include raw material:Saline cistanche, barrenwort, Semen Cuscutae, the fruit of Chinese magnoliavine, spongilla, radix glycyrrhizae, annex solution;B component includes raw material:Cynomorium songaricum, Poria cocos, prepared rhizome of rehmannia, the bighead atractylodes rhizome, moutan bark, Fructus Corni, supplement powder.Compared with prior art, the cure rate for the treatment of by Chinese herbs male's Patients with Kidney Deficiency Type of the invention and total effective rate are significantly higher than the cure rate of drug therapy male Patients with Kidney Deficiency Type and total effective rate made from prior art, and recurrence rate is low.

Description

A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription
【Technical field】
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription.
【Background technology】
At present, the live and work rhythm of people is substantially accelerated, and is busy with one's work, and the pressure born is increasing, lacks Constitution is taken exercise, and many people especially men's health level is on a declining curve year by year, and kidney deficiency, insufficiency of vital energy and blood etc. occurs, so as to lead The generation of many diseases is caused, such as physically weak alopecia, has a dizzy spell, have a pain in the back, dysphoria with smothery sensation of having a sleepless night illness, and it is impotence and premature ejaculation, preceding The sexual disorders such as row gland disease.Due to relevant knowledge shortage or idea constraint, many people are ashamed of medical treatment and voluntarily abuse of market Upper various excitants, not only accelerate body health level decrease speed, it is also possible to induce other serious diseases.Doctor trained in Western medicine circle often uses Glucocorticoid treatment kidney trouble, the pain of patient is alleviated to a certain extent, the effect of improving in a short time.But milli Uncontrolled hormone application, patient is set various irreversible serious symptoms occur, such as:The sugared cortex of long-term super physiological dose Hormone application can cause water, salt, sugar, protein and fat metabolic disturbance, class adrenocortical hyperfunction occur.Show as Central obesity, calcium uptake obstacle is caused, cause osteoporosis, severe patient also may occur from hair property fracture.Middle medical circles' treatment is more With kidney tonifying medicine, but produce little effect.
The traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, and built-in nephroyin and nephroyang, kidney deficiency divides kidney-yin deficiency and kidney-yang deficiency, be according to different diseases Shape does Coryza Treated by Syndrome Differentiation.Kidney deficiency is mostly that long-term bad habits and customs accumulation forms, and blindly can't disorderly enter tonic, or use composition Not clear tonifying kidney and strengthening yang medicine.Kidney deficiency is with pain in the back with based on aching and limp, and dizziness and tinnitus, desire for being robbed and pressed, leg knee is powerless, meets labor more very, It is sleeping then mitigate, normal recurrent exerbation.The Western medicine with the gentle physical fatigue of tonifying kidney and strengthening yang sell in the market or common Cure the symptoms, not the disease, and side effect is larger, unobvious the effect of Chinese patent drug, and health food permanence operation it is bad and expend compared with It is high.
【The content of the invention】
The technical problem to be solved in the present invention is to provide a kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, to solve to treat the treatment of kidney deficiency Imitate that the time is long, side effect is big and drug effect is low, the problem of high recurrence rate.
In order to solve the above technical problems, the present invention uses following technical scheme:
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and the component A includes pressing as follows The raw material of parts by weight meter:
60~65 portions of saline cistanches
30~35 parts of barrenwort
25~28 portions of Semen Cuscutaes
18~23 portions of fruit ofs Chinese magnoliavine
15~20 parts of spongillas
13~16 portions of radix glycyrrhizaes
6~7 parts of annex solutions;
The B component includes the following raw material counted in parts by weight:
50~55 parts of cynomorium songaricums
40~45 parts of Poria cocos
36~42 parts of prepared rhizomes of rehmannia
32~35 parts of bighead atractylodes rhizomes
22~26 parts of moutan barks
14~17 portions of Fructus Cornis
10~12 parts of supplement powder.
Preferably, the preparation method of annex solution comprises the following steps:
(1) in mass ratio 2~4:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, is received Collect crushed mixture, be placed in standing 3~6h at 35~40 DEG C;
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and Concentrated, be concentrated into the 50~55% of extract volume, collected concentrate, sterilizing, produce annex solution.
Preferably, the preparation method for augmenting powder comprises the following steps:
A. in mass ratio 12:4~6:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture With 0.5mol/L sodium chloride solutions in mass ratio 1:4~6 are put into digester and carry out boiling, collect cooking mixture;
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
The invention has the advantages that:
(1) from embodiment 1-3 data, embodiment 2 is optimum embodiment, and the fully recovering of acquisition, total efficiently individual quantity are most It is more.
(2) from the data of embodiment 1-3 and comparative example 1~15 and comparative example 16, in component A, B component and each component Raw material serve synergy in male's nephrosis Chinese medicine is prepared, controlled using the traditional Chinese medicine for invigorating kidney and strengthening yang prescription for preparing of the present invention It is good to treat the effect of male's Patients with Kidney Deficiency Type of the significant effect drug therapy more commercially available than comparative example 16 of male's Patients with Kidney Deficiency Type, and without pair Effect.
(3) traditional Chinese medicine for invigorating kidney and strengthening yang prescription of the invention is thoroughly effected a radical cure by oral administration and externally to Patients with Kidney Deficiency Type, first By being warmed to human body three acupuncture point Guanyuan points, Zusanli, point Fengfus, these three acupuncture points are distributed in the upper, middle and lower of human body, The circulation of blood can be effectively facilitated, the capillary at acupuncture point opens in Warming processes, utilizes saline cistanche, excessive sheep in component A The Chinese herbal medicines such as the leaves of pulse plants, Semen Cuscutae carry out fermentation extraction, and the macromolecular in Chinese herbal medicine is changed into small molecule by the effect of microorganism, Nursed one's health, the beneficiating ingredient of kidney tonifying, improve human body and it is absorbed, by the absorption at acupuncture point, so as to promote blood to follow Ring, human mechanism is nursed one's health using blood circulation, and nourishing is carried out to human body using the nutriment in annex solution and is supported Point, and directly act on kidney by channels and collaterals, play the solid member of kidney tonifying, the effect of warming kidney and enhancing body, while improve blood circulation Also absorption of the human body to material can be increased, then drink B component, because early stage uses component A, improve human body to B component Absorb and utilize, inside of human body system is nursed one's health by the material in B component, keep inside of human body system stable, then profit Human body kidney is further nourished with the material such as ripe, glutinous rehmannia of cynomorium songaricum, Poria cocos in B component, and using nutriment to kidney It is dirty to be nourished, during preventing nourishing, can not supplying in time for nutriment, keep the vigor of kidney.
【Embodiment】
For ease of more fully understanding the present invention, it is illustrated by following instance, these examples belong to the protection of the present invention Scope, but do not limit the scope of the invention.
In embodiment, the preparation method of annex solution comprises the following steps:
(1) in mass ratio 2~4:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, is received Collect crushed mixture, be placed in standing 3~6h at 35~40 DEG C;
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and Concentrated, be concentrated into the 50~55% of extract volume, collected concentrate, sterilizing, produce annex solution.
The preparation method of supplement powder comprises the following steps:
A. in mass ratio 12:4~6:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture With 0.5mol/L sodium chloride solutions in mass ratio 1:4~6 are put into digester and carry out boiling, collect cooking mixture;
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and the component A includes pressing as follows The raw material of parts by weight meter:
60~65 portions of saline cistanches
30~35 parts of barrenwort
25~28 portions of Semen Cuscutaes
18~23 portions of fruit ofs Chinese magnoliavine
15~20 parts of spongillas
13~16 portions of radix glycyrrhizaes
6~7 parts of annex solutions;
The B component includes the following raw material counted in parts by weight:
50~55 parts of cynomorium songaricums
40~45 parts of Poria cocos
36~42 parts of prepared rhizomes of rehmannia
32~35 parts of bighead atractylodes rhizomes
22~26 parts of moutan barks
14~17 portions of Fructus Cornis
10~12 parts of supplement powder.
The preparation process of component A is in the present invention:
S1. meter carries out taking raw material in parts by weight, is put into ball mill with 800r/min ball milling 40min, collects ball milling and mixes Compound, by ball-milled mixtures and water in mass ratio 1:3 mixing, are put into container, the boiling 50min at 100 DEG C;
S2. after boiling terminates, naturally cool to room temperature, collect cooking mixture, in mass ratio 8:1, boiling is mixed Thing mixes with the bent essence of aspergillus oryzae, is fermented 3 days at 38 DEG C, collects fermenting mixture, filtered, collected filtrate, be concentrated into filter The 50% of liquid product, collects concentrate, sterilizing, produces component A.
The preparation process of B component is in the present invention:
D1. meter is carried out taking raw material in parts by weight, and raw material is put into 60 DEG C of baking ovens and dry, pulverize, and crosses 200 mesh sieves, is received Collection sieving particle;
D2. will sieving particle and 1.6mol/L ethanol solutions in mass ratio 1:3 mixing, carry out steam blasting, collect explosion Mixture, then supercritical carbon dioxide extracting is carried out, extract is collected, is centrifuged, collects supernatant, is distilled to recover ethanol, Residue is collected, produces B component.
Below by more specific embodiment, the present invention will be described.
Embodiment 1
The preparation method of annex solution comprises the following steps:
(1) in mass ratio 4:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, collects powder Broken mixture, it is placed in standing 6h at 40 DEG C;
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and Concentrated, be concentrated into the 55% of extract volume, collected concentrate, sterilizing, produce annex solution.
The preparation method of supplement powder comprises the following steps:
A. in mass ratio 12:6:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture with 0.5mol/L sodium chloride solutions in mass ratio 1:6 are put into digester and carry out boiling, collect cooking mixture;
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and component A is included as follows by weight The raw material of number meter:
65 portions of saline cistanches
35 parts of barrenwort
28 portions of Semen Cuscutaes
23 portions of fruit ofs Chinese magnoliavine
20 parts of spongillas
16 portions of radix glycyrrhizaes
7 parts of annex solutions;
The B component includes the following raw material counted in parts by weight:
55 parts of cynomorium songaricums
45 parts of Poria cocos
42 parts of prepared rhizomes of rehmannia
35 parts of bighead atractylodes rhizomes
26 parts of moutan barks
17 portions of Fructus Cornis
12 parts of supplement powder.
Embodiment 2
The preparation method of annex solution comprises the following steps:
(1) in mass ratio 3:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, collects powder Broken mixture, it is placed in standing 5h at 38 DEG C;
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and Concentrated, be concentrated into the 53% of extract volume, collected concentrate, sterilizing, produce annex solution.
The preparation method of supplement powder comprises the following steps:
A. in mass ratio 12:5:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture with 0.5mol/L sodium chloride solutions in mass ratio 1:5 are put into digester and carry out boiling, collect cooking mixture;
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and component A is included as follows by weight The raw material of number meter:
64 portions of saline cistanches
33 parts of barrenwort
27 portions of Semen Cuscutaes
20 portions of fruit ofs Chinese magnoliavine
18 parts of spongillas
15 portions of radix glycyrrhizaes
6.5 parts of annex solutions;
The B component includes the following raw material counted in parts by weight:
53 parts of cynomorium songaricums
42 parts of Poria cocos
40 parts of prepared rhizomes of rehmannia
33 parts of bighead atractylodes rhizomes
24 parts of moutan barks
15 portions of Fructus Cornis
11 parts of supplement powder.
Embodiment 3
The preparation method of annex solution comprises the following steps:
(1) in mass ratio 2:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, collects powder Broken mixture, it is placed in standing 3h at 35 DEG C;
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and Concentrated, be concentrated into the 50% of extract volume, collected concentrate, sterilizing, produce annex solution.
The preparation method of supplement powder comprises the following steps:
A. in mass ratio 12:4:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture with 0.5mol/L sodium chloride solutions in mass ratio 1:4 are put into digester and carry out boiling, collect cooking mixture;
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected Destainer, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription include component A, B component, and component A is included as follows by weight The raw material of number meter:
60 portions of saline cistanches
30 parts of barrenwort
25 portions of Semen Cuscutaes
18 portions of fruit ofs Chinese magnoliavine
15 parts of spongillas
13 portions of radix glycyrrhizaes
6 parts of annex solutions;
The B component includes the following raw material counted in parts by weight:
50 parts of cynomorium songaricums
40 parts of Poria cocos
36 parts of prepared rhizomes of rehmannia
32 parts of bighead atractylodes rhizomes
22 parts of moutan barks
14 portions of Fructus Cornis
10 parts of supplement powder.
Comparative example 1
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that there is no B groups in traditional Chinese medicine for invigorating kidney and strengthening yang prescription Part.
Comparative example 2
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that there is no A groups in traditional Chinese medicine for invigorating kidney and strengthening yang prescription Part.
Comparative example 3
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that there is no B groups in traditional Chinese medicine for invigorating kidney and strengthening yang prescription Part, and there is no annex solution in component A.
Comparative example 4
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription in component A There is annex solution.
Comparative example 5
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that there is no A groups in traditional Chinese medicine for invigorating kidney and strengthening yang prescription Part, and without supplement powder in B component.
Comparative example 6
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription in B component There is supplement powder.
Comparative example 7
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription B component Cynomorium songaricum.
Comparative example 8
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A Saline cistanche.
Comparative example 9
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A Barrenwort.
Comparative example 10
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A Semen Cuscutae.
Comparative example 11
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A The fruit of Chinese magnoliavine.
Comparative example 12
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A Spongilla.
Comparative example 13
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A Radix glycyrrhizae.
Comparative example 14
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A Poria cocos.
Comparative example 15
It is essentially identical with the preparation technology of embodiment 2, have only the difference is that not having in traditional Chinese medicine for invigorating kidney and strengthening yang prescription component A Prepared rhizome of rehmannia.
The commercially available tonifying kidney and strengthening yang medicine of comparative example 16.
Pharmacology pharmacodynamic is tested:
1. acute toxicity test
Application mouse carries out acute toxicity testing and shown:Mouse oral gavage embodiment of the present invention 1-3 Chinese medicine, Under 488.8g crude drugs/kg dosage, there is light activity reduction, 1h or so recovery normally in mouse after administration, Continuous Observation 7 after administration My god, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight increase normal, test result indicates that:Mouse mouth The maximum dosage-feeding for taking gavage embodiment 1-3 Chinese medicine is 488.8g crude drugs/kg/d (LD50 > 488.8g crude drugs/kg).This hair The bright embodiment 1-3 daily clinical application total amount of Chinese medicine is 0.1g crude drugs/kg/d;By batheroom scale, in the mouse stomach present invention The dosis tolerata of medicine preparation is 4888 times of clinical patient.Prompt the medicine acute toxicity low, clinical application safety.
2. long term toxicity test
From SD rats, the 1-3 of the embodiment of the present invention of various concentrations (18.0,6.0,2.0g crude drugs/kg) Chinese medicine is given, Daily gavage once, continuous 90 days, lived and kill 1/2 animal (male and female half and half) after last dose, and remaining 1/2 animal continues by 24h each groups Work is killed after observing 2 weeks.Outward appearance, general behavior, food ration, the changes of weight of animal are observed during experiment, 90 days and is stopped after administration Medicine 2 weeks carry out hematologies (RBC, HB, granulophilocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, the index checking such as Histopathology.Experiment knot Fruit shows:Chinese medicine of the present invention is good in high, medium and low dosage group animal general state, appearance sign, behavioral activity, food-intake and Body weight increase change without exception;Three dosage groups and control group hematological examination, blood biochemical analysis, urine biochemical analysis exist Normal range (NR), without significant difference between group;Each group main organs histopathological examination is shown no obvious abnormalities.These parameters drug withdrawal 2 Also change is had no after week.This experiment dosage is respectively the 180 of clinical medicine dose, 60,20 times, according to this hair of result of the test Bright Chinese medicine preparation is in high, medium and low three dosage (18.0,6.0,2.0g crude drugs/kg) administration in continuous 90 days to rat without obvious Influence, without clear and definite toxicity target organ and sensitive indicator, convalescence observation also has no retardance toxic reaction, prompts the present invention's The dose safety of Chinese medicine preparation clinical practice is higher.
3. animal local excitation is tested:
The allergic reaction on guinea pigs and Rat-rectum medication irritation test of 1-3 of embodiment of the present invention Chinese medicine.As a result Show:Skin anaphylactic test, high dose group 0.8g (medicinal powder)/kg, low dose group 0.1g (medicinal powder)/kg, is respectively equivalent to plan and faces 20 times, 2.5 times of bed people's dosage [0.04g (medicinal powder)/kg], through percutaneous drug delivery, it is showed no animal and produces allergy;Rectum is used Medicine irritation test high dose group 5.0g (medicinal powder)/kg, low dose group 3.2g (medicinal powder)/kg, it is respectively equivalent to intend clinical people's use 125,80 times of amount, phenomena such as mucous membrane of rectum is without hyperemia, oedema, histopathologic examination and sky are observed within the defined time White control group compares no significant difference, has no obvious irritative response occur, its overall health of patients of the Some Animals of every group of retention, Body weight, breathing, circulation, central nervous system and four limbs activity etc., equal Non Apparent Abnormality reaction.
The illness of traditional Chinese medicine for invigorating kidney and strengthening yang prescription of the present invention is applicable, its clinical manifestation symptom:Deficiency of qi and blood, the insufficiency of the kidney yang, Have a delicate constitution, the disease such as impotence and premature ejaculation.
Diagnostic criteria:It is strict by the clinical drug demonstration plan for treating impotence kidney deficiency according to tcm treatment according to syndrome differentiation principle The standard diagnostics of such disease, the relevant Chinese medicine clinical research principle developed and published according to the Ministry of Public Health, therapeutic effect is divided into and fullyed recover from an illness More, invalid and total effective rate is judged.
The application method of traditional Chinese medicine for invigorating kidney and strengthening yang prescription:Once in the morning and once at night, use in the morning after meal, makes before sleeping at night With, first using component A, B component is reused, it is warm to Guanyuan point, Zusanli, point Fengfu progress first by 40~45 DEG C of warm water 5~10min of heat, rubbing 1min is carried out to Guanyuan point, Zusanli, point Fengfu using component A, then takes B component, each taking Measure as 15mL.
The clinical efficacy of 1-3 of the embodiment of the present invention and comparative example 1-8 treatment by Chinese herbs male's kidney deficiency is investigated, selects 160 Clinical observation on the therapeutic effect is carried out using the male of illness of the present invention, 8 groups is randomly divided into, every group 20, tracking treatment 1 month, continues Track 1 year, observe recurrence rate, first group of traditional Chinese medicine for invigorating kidney and strengthening yang prescription using the present invention of embodiment 1, second group uses implementation The traditional Chinese medicine for invigorating kidney and strengthening yang prescription of the present invention of example 2, the 3rd group of traditional Chinese medicine for invigorating kidney and strengthening yang prescription using the present invention of embodiment 3, the Four groups of traditional Chinese medicine for invigorating kidney and strengthening yang prescriptions using the present invention of comparative example 4, the 5th group of tonifying kidney and strengthening yang using the present invention of comparative example 5 Chinese prescription, the 6th group of traditional Chinese medicine for invigorating kidney and strengthening yang prescription using the present invention of comparative example 6, the 7th group uses the present invention of comparative example 7 Traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the 8th group of traditional Chinese medicine for invigorating kidney and strengthening yang prescription using the present invention of comparative example 8, the like, often Traditional Chinese medicine for invigorating kidney and strengthening yang prescription in the corresponding corresponding comparative example of group, comparative example 16 use tonifying kidney and strengthening yang commercially available in comparative example 8 Medicine.
Therapeutic effect:
Observation of curative effect result see the table below.
As seen from the above table:(1) from embodiment 1-3 data, embodiment 2 is optimum embodiment, and acquisition is fully recovered, always Efficiently individual quantity is most, and recurrence rate is minimum.
(2) from the data of embodiment 1-3 and comparative example 1~15 and comparative example 16, in component A, B component and each component Raw material serve synergy in male's nephrosis Chinese medicine is prepared, controlled using the traditional Chinese medicine for invigorating kidney and strengthening yang prescription for preparing of the present invention It is good to treat the effect of male's Patients with Kidney Deficiency Type of the significant effect drug therapy more commercially available than comparative example 16 of male's Patients with Kidney Deficiency Type, and without pair Effect.
(3) from clinical data, component A, B component in the present invention serve collaboration in treatment improves male's kidney deficiency Effect, significantly improve treatment the fully recovering of male's Patients with Kidney Deficiency Type, total efficiently individual quantity.The traditional Chinese medicine for invigorating kidney and strengthening yang prescription of the present invention leads to Cross oral administration and externally thoroughly to effect a radical cure Patients with Kidney Deficiency Type, first by entering human body three acupuncture point Guanyuan points, Zusanli, point Fengfus Row warm, these three acupuncture points are distributed in the upper, middle and lower of human body, can effectively facilitate the circulation of blood, the acupuncture point in Warming processes Capillary opens, and using the liquid for by fermentation extract preparation in component A, quickly can be absorbed by skin and acupuncture point, By the absorption at acupuncture point, so as to stimulate circulation, human body is nursed one's health using blood circulation, uses the nutrition in annex solution Material carries out nourishing nutrient to human body, and may also pass through channels and collaterals and directly act on kidney, plays the solid member of kidney tonifying, warming kidney and enhancing body The effect of, while improve blood circulation and can also increase absorption of the human body to material, B component is then drunk, because early stage uses A groups Part, absorption and utilization of the human body to B component are improved, inside of human body system is nursed one's health by the material in B component, is kept Inside of human body system is stable, recycles establishing-Yang material to improve renal function, and kidney is nourished using nutriment, keeps The vigor of kidney;While also in that:
1. saline cistanche:Kidney-replenishing, benefiting essence-blood, ease constipation road.Main decline of kidney-YANG, the impotence of asthenia of essence and blood, seminal emission.
2. barrenwort:Barrenwort acrid-sweet flavor is warm-natured, walks liver kidney two warp.To mend the gate of vitality, strengthening the essence gas, strengthening the bones and muscles, tonifying kidney and strengthening yang Key medicine, clinic be usually used in treating impotence in male do not lift, the disease such as involuntary emission premature ejaculation, urinary incontinence and female sterility.
3. Semen Cuscutae:It is that the flat good medicine for mending kidney,liver,spleen, clinic are mainly used in lumbago due to the kidney deficiency, impotence and seminal emission, urine simply Frequently, the kidney yin yang deficiency syndrome of the dark loose stool of uterus cold infertile, mesh.
4. the fruit of Chinese magnoliavine:Contain schizandrin (Schisandrin C23H3206) and vitamin C, resin, tannin and a small amount of Carbohydrate.Have and astringe the lung to stop cough, nourish puckery essence, the effect of antidiarrheal hidroschesis.
5. spongilla:With tonifying the kidney and support yang, the effect of astringent sperm contracting urine.It is usually used in impotence, passes out semen, gonorrhoea is small under cold of insufficiency type band Fecal incontinence, scrotum is wet to itch.
6. radix glycyrrhizae:For the root and rhizome of herbaceos perennial radix glycyrrhizae, property sweet taste, the thoughts of returning home, lung, spleen, stomach.Has tonifying spleen QI invigorating, moisten the lung and relieve the cough, relieving spasm to stop pain, the work(for relaxing the property of medicine.
7. cynomorium songaricum:Can kidney tonifying, strengthening the essence, moisturize, impotence and seminal emission, soreness and weakness of waist and knees, dry constipation of intestines are cured mainly, to paralysing and improvement property Function is weak to have certain effect.
8. Poria cocos:It is mild-natured, slightly sweet flavor, the people of all seminal emissions, no matter actual situation, all preferably eat, asthenic symptoms seminal emission, Poria cocos has the help heart The work(of spleen, damp and hot seminal emission, Poria cocos have the effect of invigorating spleen to remove dampness.
9. prepared rhizome of rehmannia:It is sweet, slightly warm in nature, there is nourishing yin and supplementing blood, beneficial to spirit and marrow and other effects.Cure mainly the deficiency of liver-yin and kidney-yin, waist and knee acid Soft, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, dizziness and tinnitus, poliosis etc. Disease.
10. the bighead atractylodes rhizome:Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, it is antiabortive the effect of, for spleen eating less, abdominal distention diarrhea, phlegm and retained fluid Feel dizzy and heart palpitations, oedema, spontaneous perspiration, fetal irritability.
11. matrimony vine:Nourishing the liver, nourshing kidney, moistening lung.
12. Semen Juglandis:Walnut is sweet, warm-natured;Enter kidney, lung channel;It can invigorate the kidney and stop nocturnal emission, warm lung Dingchuan, relax bowel;Cure mainly kidney Void asthma is coughed, pain in the back flaccidity of lower limbs, impotence and seminal emission, frequent urination, urolithiasis, dry feces.
13. moutan bark:Heat enters ying blood, febrile virulent maculae, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, closed dysmenorrhea, falls and flutters The pain of injury, carbuncle sore tumefacting virus.
14. Fructus Corni:Contain 16 kinds of amino acid in pulp, in addition, containing element necessary to a large amount of human bodies.In addition, contain There are the compositions such as physiologically active stronger saponin raw sugar, polysaccharide, malic acid, tartaric acid, phenols, resin, tannin and vitamin A, C. Its sour-puckery flavor, there is nourishing, stomach invigorating, diuresis, filling liver kidney, replenishing qi and blood and other effects.
15. black soya bean:Composition containing abundant protein, unrighted acid, phosphide, calcium, phosphorus, iron, potassium, sodium, carrotene, Vitamin B1, vitamin B2, vitamin B12, nicotinic acid, folic acid, gossypose, stachyose, choline, daizeol, saponin(e etc..Kidney tonifying It is beneficial cloudy, invigorating spleen to remove dampness, except thermal detoxification.
16. sea-tangle:Contain the mineral matter elements such as abundant iodine.Sea-tangle heat content is low, protein content is medium, mineral matter is rich Richness, have reducing blood lipid, hypoglycemic, regulation is immune, anticoagulation, antitumor, lead discharging removing toxic substances and a variety of biological functions such as anti-oxidant.
17. tomato:Promote the production of body fluid to quench thirst, stomach strengthening and digestion promoting, clearing away heat and removing summer, the function such as kidney tonifying diuresis, can control consumption of body fluid caused by febrile disease it is thirsty, The illness such as Sheng in poor appetite, hot summer weather.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies Change, equivalent substitution, improvement etc., should be included in the scope of the protection.

Claims (1)

1. a kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription, the Chinese prescription includes component A, B component, it is characterised in that the component A bag Include the following raw material counted in parts by weight:
60~65 portions of saline cistanches
30~35 parts of barrenwort
25~28 portions of Semen Cuscutaes
18~23 portions of fruit ofs Chinese magnoliavine
15~20 parts of spongillas
13~16 portions of radix glycyrrhizaes
6~7 parts of annex solutions;
The preparation method of the annex solution comprises the following steps:
(1) in mass ratio 2~4:1:5, sea-tangle, tomato and 0.3mol/L lactic acid solutions are put into pulverizer and crushed, collects powder Broken mixture, it is placed in standing 3~6h at 35~40 DEG C;
(2) after standing terminates, standing mixt is collected, and carries out supercritical carbon dioxide extracting, collects extract, and carry out Concentration, the 50~55% of extract volume is concentrated into, collects concentrate, sterilizing, produce annex solution;
The B component includes the following raw material counted in parts by weight:
50~55 parts of cynomorium songaricums
40~45 parts of Poria cocos
36~42 parts of prepared rhizomes of rehmannia
32~35 parts of bighead atractylodes rhizomes
22~26 parts of moutan barks
14~17 portions of Fructus Cornis
10~12 parts of supplement powder;
The preparation method of the supplement powder comprises the following steps:
A. in mass ratio 12:4~6:3, matrimony vine, Semen Juglandis and black soya bean are put into pulverizer and crushed, by crushed mixture with 0.5mol/L sodium chloride solutions in mass ratio 1:4~6 are put into digester and carry out boiling, collect cooking mixture;
B. above-mentioned cooking mixture is subjected to press filtration, collects pressing filtering liquid, pressing filtering liquid is decolourized using activated carbon, collected and decolourize Liquid, by destainer and polyglutamic acid in mass ratio 2:1 is well mixed, freeze-drying, collects dried object, produces supplement powder.
CN201711146607.0A 2017-11-17 2017-11-17 A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription Pending CN107854562A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711146607.0A CN107854562A (en) 2017-11-17 2017-11-17 A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711146607.0A CN107854562A (en) 2017-11-17 2017-11-17 A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription

Publications (1)

Publication Number Publication Date
CN107854562A true CN107854562A (en) 2018-03-30

Family

ID=61703168

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711146607.0A Pending CN107854562A (en) 2017-11-17 2017-11-17 A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription

Country Status (1)

Country Link
CN (1) CN107854562A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114515007A (en) * 2022-03-02 2022-05-20 文成国 Diet therapy formula for treating kidney-yin deficiency and kidney-yang deficiency

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1628750A (en) * 2004-08-26 2005-06-22 由丽萍 Yang invigorating medicine
CN104435351A (en) * 2014-11-14 2015-03-25 马静 Traditional Chinese medicine prescribed preparation for tonifying kidneys and strengthening yang and application of traditional Chinese medicine prescribed preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1628750A (en) * 2004-08-26 2005-06-22 由丽萍 Yang invigorating medicine
CN104435351A (en) * 2014-11-14 2015-03-25 马静 Traditional Chinese medicine prescribed preparation for tonifying kidneys and strengthening yang and application of traditional Chinese medicine prescribed preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
21CN生活: "西红柿海带汤可以壮阳补肾", 《FQ.VEGNET.COM.CN/NEWS/650367.HTML》 *
童安荣: "《慢性肾脏病诊疗与保健》", 31 December 2014, 阳光出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114515007A (en) * 2022-03-02 2022-05-20 文成国 Diet therapy formula for treating kidney-yin deficiency and kidney-yang deficiency

Similar Documents

Publication Publication Date Title
CN104322617B (en) Biscuit of a kind of auxiliary hyperglycemic and preparation method thereof
CN102048933A (en) Chinese medicinal composition for treating infantile diarrhea and preparation method thereof
CN104225417A (en) Traditional Chinese medicine composition with function of assisting improvement of memory and preparation method thereof
CN110575516A (en) Kidney-tonifying and qi-benefiting paste and preparation method thereof
CN106490558A (en) A kind of health-care honey and preparation method thereof
CN105920269A (en) Health-care medicinal liquor for females
CN103330837B (en) Traditional Chinese medicine composition for curing osteoporosis of menopausal women
CN102579896A (en) Natural Chinese herbal medicine anticancer pill
CN104957515A (en) Steamed buns assisting to lower blood sugar and preparation method thereof
CN104825821A (en) Medicine for treating diabetes and preparation method thereof
CN107854562A (en) A kind of traditional Chinese medicine for invigorating kidney and strengthening yang prescription
CN104548049A (en) Traditional Chinese medicine composition for treating senile osteoporosis and preparation method thereof
CN104740415A (en) Traditional Chinese medicine preparation for treating osteoporosis of lactation-period female
CN110538308A (en) Traditional Chinese medicine composition for hair growth and preparation method thereof
CN110237196A (en) It is a kind of to increase for teenager and the composition for controlling weight and preparation method thereof
CN108310111B (en) Traditional Chinese medicine formula for benefiting qi and nourishing blood, preparation method and application thereof, medicated diet for benefiting qi and nourishing blood and preparation method thereof
CN106334145A (en) Cough-relieving and intestine-lubricating honey and preparation method thereof
CN117717599A (en) Traditional Chinese medicine composition for relieving physical fatigue and preparation method and application thereof
CN104825879A (en) Spleen-strengthening and kidney-tonifying capsule for clinical nursing and preparation method thereof
CN105561192A (en) Cordyceps sinensis and fructus hippophae healthy medicinal liquor
CN104840864A (en) Traditional Chinese medicine preparation for treating infantile diarrhea caused by spleen deficiency
CN105031562A (en) Blood activating and dryness moistening wine
CN104938697A (en) Health-care tea drink capable of relieving fatigue
CN105031291A (en) Dendrobium officinale traditional Chinese medicinal composition having kidney tonifying function and preparation of dendrobium officinale traditional Chinese medicinal composition
CN104306769A (en) Traditional Chinese medicine composition for treating primary hypotension

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180330

RJ01 Rejection of invention patent application after publication