CN107854194A - The absorbable composite patch and manufacture method repaired for shoulder sleeve - Google Patents

The absorbable composite patch and manufacture method repaired for shoulder sleeve Download PDF

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Publication number
CN107854194A
CN107854194A CN201710995575.5A CN201710995575A CN107854194A CN 107854194 A CN107854194 A CN 107854194A CN 201710995575 A CN201710995575 A CN 201710995575A CN 107854194 A CN107854194 A CN 107854194A
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CN
China
Prior art keywords
knitted body
absorbable
layer
trend
repaired
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201710995575.5A
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Chinese (zh)
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CN107854194B (en
Inventor
陈晓
季杰
赖卫国
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Shanghai Ligetai Biological Technology Co Ltd
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Shanghai Ligetai Biological Technology Co Ltd
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Priority to CN201710995575.5A priority Critical patent/CN107854194B/en
Publication of CN107854194A publication Critical patent/CN107854194A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063Implantable repair or support meshes, e.g. hernia meshes

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  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention provides a kind of absorbable composite patch repaired for shoulder sleeve, and comprising knitted body, the knitted body includes one or more weaving units, and the weaving unit forms support basic unit and absorbable layer by being stacked on thickness bearing of trend;Absorbable layer is arranged on support basic unit along one of end face in two end faces of thickness bearing of trend or whole end faces;The support basic unit is made with absorbable layer by degradable material.Correspondingly, present invention also offers a kind of manufacture method for the absorbable composite patch repaired for shoulder sleeve.The present invention has higher initial fixing intensity, while shoulder can be made to tuck inside the sleeve and combined closely between the head of humerus, reduces gap;And as collagen is gradually degraded, human body itself connective tissue is grown into entering sticking patch micropore, forms overall structure, accelerates the healing of shoulder sleeve.

Description

The absorbable composite patch and manufacture method repaired for shoulder sleeve
Technical field
The present invention relates to medical instruments field, in particular it relates to a kind of absorbable composite patch repaired for shoulder sleeve and Manufacture method.
Background technology
Rotator cuff injury is shoulder joint common injury, and patient is often because there is shoulder pain after certain wound, limitation of activity, The cardinal symptom of rotator cuff injury has:Pain on the outside of shoulder, and can be radiated to neck, upper arm parts;Shoulder abduction or to do shoulder fast from outward turning During the hip beats of fast inward turning, pain can be aggravated;When shoulder does outward turning abduction resistance, also there is obvious pain in shoulder;Shoulder sleeve damage Hinder the time it is longer when, also have triangle amyotrophia.In normal population, rotator cuff injury accounts for the 5%~40% of shoulder joint illness, and 17%~41% was accounted in crowd more than 60 years old.
Clinically rotator cuff injury recovery technique has single, double row with line holdfast at present, wears osteosynthesis technology.With repair the device Improvement and recovery technique raising, substantial amounts of rotator cuff injury can carry out tendon-osteosynthesis, but still have part shoulder sleeve because of tear Huge and contracture of tissue can not be repaired, therefore clinically occur what some tucked inside the sleeve by shifting tendon technology to repair shoulder Technology, most common of which are pectoralis major transfer techniques and latissimus dorsi transfer techniques.But when patient's shoulder joint has front upper place not During steady or huge rotator cuff injury, no matter in pain or functionally effect and not satisfactory.Although shoulder sleeve repairs skill Art has had obvious progress, but postoperative still suffer from 38%~94% and tear rate, particularly degenerated rotator cuff injury again Tendon-knitting degree is relatively low.
Preferable shoulder sleeve is repaired:Higher initial fixing intensity, reach shoulder sleeve initial strength;Shoulder is tucked inside the sleeve between the head of humerus Gap is as far as possible few;Remain able to maintain mechanically stable after activity repeatedly;Mechanical stability can be kept during loaded cycle load;It is excellent Change the biological environment at " healing position ".
The content of the invention
For in the prior art the defects of, it is an object of the invention to provide it is a kind of for shoulder sleeve repair absorbable compound benefit Piece and manufacture method.
The absorbable composite patch repaired according to being tucked inside the sleeve provided by the present invention for shoulder, comprising knitted body, the knitted body bag Containing one or more weaving units,
The weaving unit forms support basic unit and absorbable layer by being stacked on thickness bearing of trend;Absorbable layer is set Put in support basic unit along one of end face in two end faces of thickness bearing of trend or whole end faces;
The support basic unit is made with absorbable layer by degradable material.
Preferably, multiple weaving units of same layer are sequentially connected to form braiding along thickness bearing of trend in knitted body Layer;
Comprising multiple braiding layers, braiding layer stacks gradually on braiding body thickness bearing of trend;
Relative can be slided between two neighboring braiding layer and cause knitted body original state and deployed condition both Changed between state:
Under the original state, multiple braiding layers concordantly stack, and on knitted body cross section, multiple weaving units are in matrix Arrangement, the width of knitted body are minimum;
Under the deployed condition, multiple braiding layers stagger stacking, and on knitted body cross section, multiple weaving units are in parallel Quadrangle arranges that knitted body width becomes big.
Preferably, the knitted body also includes elastic threads;
Two weaving units adjacent along thickness bearing of trend of elastic threads connection knitted body in an initial condition;
Under deployed condition, elastic threads are in extended state.
Preferably, both ends of the knitted body along width bearing of trend be respectively arranged with the first traction piece, the second traction piece this two Individual traction piece;
Along along braiding body thickness bearing of trend, the first traction piece, the second traction piece are connected in outermost In two braiding layers.
Preferably, the traction piece is with weaving body by integral forming or being fixedly connected;
Traction piece includes pull rope, and being provided with one or more along the either side in the both sides of knitted body width leads Messenger, the pull rope of the same side are connected in same braiding layer;Pull rope relative and knitted body in both ends in the axial direction The other end of one end of connection forms free end, and the free end of more pull ropes is separated from each other, partly connects or be all connected;Or Person,
The traction piece is the weaving unit protruded along knitted body width bearing of trend.
Preferably, the weaving unit shape of cross section is arc;Under the original state, knitted body shape of cross section is in Imbricate.
Preferably, also comprising elastic overlay film;Knitted body is coated by the elastic overlay film in whole or in part;
Elastic overlay film is changed between original state and deployed condition both states with knitted body and produces elastic deformation.
Preferably, multiple weaving units in single braiding layer are integrally formed, bond or suture successively successively.
Preferably, the absorbable layer material is collagen;
The support basic unit is polyalcohol stephanoporate fabric, and support basic unit is made up of following any or various material:
-- collagen/polyvinyl alcohol composite monofilament or multifilament;
-- polylactic acid base polymer monofilament or multifilament.
Present invention also offers a kind of manufacture method for the absorbable composite patch repaired for shoulder sleeve, following step is included Suddenly:
Step A:By obtaining polyalcohol stephanoporate fabric to silk thread warp knit weaving made of degradation material;
Step B:Polyalcohol stephanoporate fabric is carried out by laser, ultrasonic wave or hot knife to cut acquisition support basic unit;
Step C:Collagen film is processed into by Static Spinning;
Step D:Collagen film is compounded in support basic unit and forms absorbable layer.
Compared with prior art, the present invention has following beneficial effect:
1st, the present invention has higher initial fixing intensity, while shoulder can be made to tuck inside the sleeve and combined closely between the head of humerus, subtracts Few gap;And as collagen is gradually degraded, human body itself connective tissue is grown into entering sticking patch micropore, is formed overall Structure, accelerate the healing of shoulder sleeve.
2nd, support basic unit has a good biodegradability in the present invention, excellent mechanical strength, good compliance, And tissue remodeling can be assisted well.
3rd, the absorbable layer in the present invention is natural activity albumen, has relatively low immunogenicity, good bio-compatible Property and histocompatbility, itself and its catabolite it is nontoxic to cell and body, or less will not cause inflammation and immune row Reprimand reaction.
4th, circumscribed circle diameter is smaller in an initial condition for the knitted body that the present invention uses, convenient to be passed through from otch;Pass through Stretching, can step by step deploy, meet the needs of different developed areas.
5th, the present invention can solve the problem that operation at present is higher and tear rate problem again, and because tear it is huge can not effectively repair The problem of benefit, there is larger clinical meaning.
Brief description of the drawings
The detailed description made by reading with reference to the following drawings to non-limiting example, further feature of the invention, Objects and advantages will become more apparent upon:
Fig. 1 is knitted body structural representation;
Fig. 2 is that weaving unit material forms schematic diagram;
Fig. 3 is knitted body original state structural representation;
Fig. 4 is that knitted body is stretched preliminary deployed configuration schematic diagram;
Fig. 5 is stretched for knitted body and further spreads out structural representation;
Fig. 6 is the knitted body structural representation for coating flexible overlay film.
Shown in figure:
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to the technology of this area Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this area For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention Protection domain.
In the description of the invention, it is to be understood that term " on ", " under ", "front", "rear", "left", "right", " perpendicular Directly ", the orientation of the instruction such as " level ", " top ", " bottom ", " interior ", " outer " or position relationship are based on orientation shown in the drawings or position Relation is put, it is of the invention necessary with simplified description, rather than the device or element of instruction or hint meaning to be for only for ease of description With specific orientation, with specific azimuth configuration and operation, therefore be not considered as limiting the invention.
As shown in Figure 1 and Figure 2, in embodiment, the absorbable composite patch repaired of being tucked inside the sleeve provided by the present invention for shoulder, which includes, to be compiled Body 1 is knitted, the knitted body 1 includes weaving unit 100 again, and the weaving unit 100 is by being stacked on shape on thickness bearing of trend Into support basic unit 2 and absorbable layer 3, absorbable layer 3 is arranged on two end faces of the support basic unit 2 along thickness bearing of trend.Support Basic unit 2 is polyalcohol stephanoporate fabric, plays mechanical support, there is provided mechanical strength, support basic unit 2 is by following any or appoint more Kind material is made:Collagen/polyvinyl alcohol composite monofilament or multifilament, polylactic acid base polymer monofilament or multifilament, such as PLLA, PLGA, PGLA, PGA etc..Polyalcohol stephanoporate fabric is formed by warp knit weaving, then is cut through laser or ultrasonic wave or hot knife into specific Shape;So that support basic unit 2 has good biodegradability, excellent mechanical strength, good compliance, and energy very well Assistance tissue remodeling.The absorbable material of layer 3 uses collagen up and down, and collagen is a kind of natural activity albumen, is had Relatively low immunogenicity, good biocompatibility and histocompatbility, itself and its catabolite to cell and body without Poison, or less it will not cause inflammation and immunological rejection.Absorbable layer 3 is processed to form and be compounded in branch support group by Static Spinning Sandwich construction is formed on layer 2, makes knitted body 1 that there is excellent histocompatbility, accelerates tissue growth.In preference, knitted body 1 Only to include a weaving unit 100, that is to say, that knitted body 1 is integrally formed, in use, by fold with expansion come Surface area size is adjusted, adapts to the use demand under different situations, but when through small otch, the structure operation is got up less It is convenient.Preferably, the absorbable layer 3 can also be only positioned at support basic unit 2 along wherein the one of two end faces of thickness bearing of trend On individual end face, the difficulty of processing of knitted body 1 is reduced, but correspondingly, therapeutic effect can decrease.
In embodiment, as shown in Figures 3 to 5, knitted body 1 includes multiple weaving units 100, prolongs in knitted body 1 along thickness The multiple weaving units 100 for stretching same layer on direction are sequentially connected to form braiding layer 10, multiple weaving units in braiding layer 10 100 are integrally formed, bond or suture successively successively.Comprising multiple braiding layers 10, braiding layer 10 extends in the thickness of knitted body 1 Stacked gradually on direction, relative can be slided between two neighboring braiding layer 10 and cause knitted body 1 in original state and expansion Changed between both states of state:As shown in figure 3, under the original state, multiple braiding layers 10 concordantly stack, in knitted body On 1 cross section, multiple weaving units 100 are in matrix arrangements, and the width of knitted body 1 is minimum;As shown in Figure 4, Figure 5, the expansion Under state, multiple braiding layers 10 stagger stacking, on the cross section of knitted body 1, multiple parallelogram cloth of weaving unit 100 Put, the width of knitted body 1 becomes big.The knitted body 1 also includes elastic threads 4, and elastic threads 4 connect knitted body 1 in an initial condition Two weaving units 100 adjacent along thickness bearing of trend, fitting is pulled by two neighboring braiding layer 10;When between braiding layer 10 When mutually staggering, elasticity is also stretched, in the presence of thickness bearing of trend component so that knitted body 1 keeps overall structure Stability.Both ends of the knitted body 1 along width bearing of trend are respectively arranged with the first traction piece 51, the second traction piece 52, on edge On the thickness bearing of trend of knitted body 1, the first traction piece 51, the second traction piece 52 are connected in outermost two braidings On layer 10, described traction piece can be pull rope or the weaving unit protruded in the direction of the width 100, along volume Knit and one or more pull rope is provided with the either side in the both sides of the width of body 1, the pull rope of the same side is connected to together In one braiding layer 10;Pull rope in the axial direction in both ends with respect to the one end being connected with knitted body 1 the other end formed from By holding, the free end of more pull ropes is separated from each other, partly connects or be all connected, and the setting of traction piece contributes to doctor to make The surface area of knitted body 1 is adjusted during.In addition, as shown in fig. 6, be also wrapped on elastic overlay film 6 around knitted body 1, elasticity Overlay film 6 coat knitted body 1 upper surface and lower surface, and the both ends of elastic overlay film 6 respectively with knitted body 1 in the width direction two End is fastenedly connected, it is preferable that elastic overlay film 6 circumferentially coats knitted body 1, and with the weaving unit 100 in the most upper left corner, most bottom right The weaving unit 100 at angle is fastenedly connected respectively, and when such occurring area of knitted body 1 changes, elastic overlay film 6, which is also pulled, to deploy, Be advantageous to clamp knitted body 1 from upper and lower both direction.Preferably, the shape of cross section of weaving unit 100 is arc, described Under original state, the shape of cross section of knitted body 1 is in imbricate, and the recess of arc weaving unit 100 forms holding tank, is just accommodated One layer of weaving unit 100, it can play a part of fixing in width bearing of trend, knitted body 1 is steady under increase deployed condition It is qualitative;In addition, weaving unit 100, because arcuate structure, when by the component of width, both ends are drawn close to intermediate deformation, Also the overall structure of weaving unit 100 can be made even closer.
Operation principle:Before implantation, knitted body 1 is in imbricate to the present invention, as shown in figure 3, due to being imbricate, knitted body 1 maximum circumscribed circle diameter is smaller, so as to readily pass through small otch.After knitted body 1 passes through small otch, as shown in figure 4, Traction piece is pulled to deploy braiding layer 10 step by step.Can be further by braiding layer 10 as shown in figure 5, pulling on traction piece Expansion, meet the needs of the different developed area of doctor.Patch is kept between two neighboring braiding layer 10 in the presence of elastic threads 4 Close, the elastic overlay film 6 of the periphery of knitted body 1 deploys that elastic deformation occurs with knitted body 1, in above-below direction in the presence of screen resilience Knitted body 1 is clamped, and ensures the smooth of the upper and lower surface of knitted body 1.
Present invention also offers a kind of above-mentioned manufacture method for being used for the absorbable composite patch that shoulder sleeve is repaired, comprising with Lower step:Step A:By obtaining polyalcohol stephanoporate fabric to silk thread warp knit weaving made of degradation material;Step B:Pass through Laser, ultrasonic wave or hot knife carry out cutting acquisition support basic unit 2 to polyalcohol stephanoporate fabric;Step C:Processed and made by Static Spinning Into collagen film;Step D:Collagen film is compounded in support basic unit 2 and forms absorbable layer 3.
The specific embodiment of the present invention is described above.It is to be appreciated that the invention is not limited in above-mentioned Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow Ring the substantive content of the present invention.In the case where not conflicting, the feature in embodiments herein and embodiment can any phase Mutually combination.

Claims (10)

1. a kind of absorbable composite patch repaired for shoulder sleeve, it is characterised in that comprising knitted body, the knitted body includes one Individual or multiple weaving units,
The weaving unit forms support basic unit and absorbable layer by being stacked on thickness bearing of trend;Absorbable layer is arranged on Basic unit is supported along one of end face in two end faces of thickness bearing of trend or whole end faces;
The support basic unit is made with absorbable layer by degradable material.
2. the absorbable composite patch according to claim 1 repaired for shoulder sleeve, it is characterised in that along thickness in knitted body Multiple weaving units of same layer are sequentially connected to form braiding layer on degree bearing of trend;
Comprising multiple braiding layers, braiding layer stacks gradually on braiding body thickness bearing of trend;
It relative can be slided between two neighboring braiding layer and cause knitted body in original state and both states of deployed condition Between change:
Under the original state, multiple braiding layers concordantly stack, and on knitted body cross section, multiple weaving units are in matrix cloth Put, the width of knitted body is minimum;
Under the deployed condition, multiple braiding layers stagger stacking, and on knitted body cross section, multiple weaving units are in parallel four side Shape arranges that knitted body width becomes big.
3. the absorbable composite patch according to claim 2 repaired for shoulder sleeve, it is characterised in that the knitted body is also Include elastic threads;
Two weaving units adjacent along thickness bearing of trend of elastic threads connection knitted body in an initial condition;
Under deployed condition, elastic threads are in extended state.
4. the absorbable composite patch according to claim 3 repaired for shoulder sleeve, it is characterised in that knitted body is along width The both ends of bearing of trend are respectively arranged with the first traction piece, the second traction piece the two traction pieces;
Along along braiding body thickness bearing of trend, the first traction piece, the second traction piece are connected in outermost two In braiding layer.
5. it is according to claim 4 for shoulder sleeve repair absorbable composite patch, it is characterised in that the traction piece with Braiding body by integral forming is fixedly connected;
Traction piece includes pull rope, and one or more traction is provided with along the either side in the both sides of knitted body width Rope, the pull rope of the same side are connected in same braiding layer;Pull rope is relative in both ends in the axial direction to be connected with knitted body The other end of the one end connect forms free end, and the free end of more pull ropes is separated from each other, partly connects or be all connected;Or Person,
The traction piece is the weaving unit protruded along knitted body width bearing of trend.
6. the absorbable composite patch according to claim 3 repaired for shoulder sleeve, it is characterised in that the weaving unit Shape of cross section is arc;Under the original state, knitted body shape of cross section is in imbricate.
7. the absorbable composite patch according to claim 2 repaired for shoulder sleeve, it is characterised in that also covered comprising elasticity Film;Knitted body is coated by the elastic overlay film in whole or in part;
Elastic overlay film is changed between original state and deployed condition both states with knitted body and produces elastic deformation.
8. the absorbable composite patch according to claim 2 repaired for shoulder sleeve, it is characterised in that in single braiding layer Multiple weaving units be integrally formed, successively bond or suture successively.
9. the absorbable composite patch according to claim 1 repaired for shoulder sleeve, it is characterised in that the absorbable layer Material is collagen;
The support basic unit is polyalcohol stephanoporate fabric, and support basic unit is made up of following any or various material:
-- collagen/polyvinyl alcohol composite monofilament or multifilament;
-- polylactic acid base polymer monofilament or multifilament.
10. a kind of manufacture method for the absorbable composite patch repaired for shoulder sleeve, it is characterised in that comprise the steps of:
Step A:By obtaining polyalcohol stephanoporate fabric to silk thread warp knit weaving made of degradation material;
Step B:Polyalcohol stephanoporate fabric is carried out by laser, ultrasonic wave or hot knife to cut acquisition support basic unit;
Step C:Collagen film is processed into by Static Spinning;
Step D:Collagen film is compounded in support basic unit and forms absorbable layer.
CN201710995575.5A 2017-10-23 2017-10-23 Absorbable composite patch for rotator cuff repair and manufacturing method Active CN107854194B (en)

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CN107854194B CN107854194B (en) 2023-06-23

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109732806A (en) * 2019-02-14 2019-05-10 上海电气风电集团有限公司 For the pultrusion part of wind electricity blade, the method for filling and wind electricity blade of wind electricity blade
CN111803713A (en) * 2020-05-29 2020-10-23 广州新诚生物科技有限公司 Woven film, woven bag and weaving method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103418031A (en) * 2012-05-17 2013-12-04 天津市康尔医疗器械有限公司 Absorbable endocranium healing patch and preparation method thereof
CN105536071A (en) * 2016-01-21 2016-05-04 东华大学 Polylactic acid/polycaprolactone/polypropylene composite pelvic floor patch and preparation method thereof
CN106390204A (en) * 2016-11-16 2017-02-15 浙江省人民医院 Composite type artificial dura mater and preparation method
CN106955420A (en) * 2017-02-24 2017-07-18 清华大学 Minimally invasive implantation end based on shape-memory material is bootstrapped opening structure
CN208864566U (en) * 2017-10-23 2019-05-17 上海利格泰生物科技有限公司 Absorbable composite patch for rotator cuff reparation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103418031A (en) * 2012-05-17 2013-12-04 天津市康尔医疗器械有限公司 Absorbable endocranium healing patch and preparation method thereof
CN105536071A (en) * 2016-01-21 2016-05-04 东华大学 Polylactic acid/polycaprolactone/polypropylene composite pelvic floor patch and preparation method thereof
CN106390204A (en) * 2016-11-16 2017-02-15 浙江省人民医院 Composite type artificial dura mater and preparation method
CN106955420A (en) * 2017-02-24 2017-07-18 清华大学 Minimally invasive implantation end based on shape-memory material is bootstrapped opening structure
CN208864566U (en) * 2017-10-23 2019-05-17 上海利格泰生物科技有限公司 Absorbable composite patch for rotator cuff reparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109732806A (en) * 2019-02-14 2019-05-10 上海电气风电集团有限公司 For the pultrusion part of wind electricity blade, the method for filling and wind electricity blade of wind electricity blade
CN109732806B (en) * 2019-02-14 2021-06-04 上海电气风电集团股份有限公司 Pultrusion piece for wind power blade, pouring method for wind power blade and wind power blade
CN111803713A (en) * 2020-05-29 2020-10-23 广州新诚生物科技有限公司 Woven film, woven bag and weaving method

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