CN107837380A - A kind of Chinese medicine composition for treating cancer pain and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating cancer pain and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for treating cancer pain and preparation method thereof, it is characterised in that the Chinese medicine composition is made up of the raw material of following parts by weight：15 20 parts of psoralea corylifolia,15 25 parts of pericarpium zanthoxyli,36 parts of asarum,10 15 parts of Chinese cassia tree,15 20 parts of monkshood,10 15 parts of cassia twig,10 15 parts of the root of three-nerved spicebush,10 15 parts of evodia rutaecarpa,15 20 parts of fennel seeds,10 15 parts of rhizoma zingiberis,10 15 parts of peach kernel,10 20 parts of root tuber of aromatic turmeric,10 15 parts of Fructus meliae toosendan,10 15 parts of Sculellaria barbata,10 20 parts of Paris polyphylla,10 15 parts of field pennycress,20 30 parts of Hedyotidis Diffusae,15 20 parts of rhizoma nelumbinis,The present invention is using psoralea corylifolia as monarch drug in a prescription,Using pericarpium zanthoxyli and asarum as ministerial drug,With Chinese cassia tree,Monkshood,Cassia twig,Root of three-nerved spicebush etc. is adjutant,Using rhizoma nelumbinis to make medicine,Formula is reasonable,For cancer pain,Start with from overall regulation and control angle and conditioning and treating is carried out by number of ways,Warm in pain,Tonify the kidney and support yang,Warming meridian,Promoting qi circulation and relieving pain,Promoting blood circulation,It is adapted to long-term use.
Description
Technical field
Patent of the present invention is related to a kind of Chinese medicine, especially a kind of Chinese medicine composition for treating cancer pain and its preparation side
Method, belong to technical field of traditional Chinese medicines.
Background technology
Cancer pain is generally referred to by the directly caused pain of tumour, tumor invading or pressuring neural root, nerve cord, nerve
Clump or nerve；Invade brain and spinal cord；Tumor invading periosteum or bone；Invade parenchymal viscera and cavity internal organs；Invade or stifled
Fill in vascular system；Tumour causes local necrosis, ulcer, inflammation etc.；Serious pain can be caused in these cases.In tumour
Caused pain, is also considered as cancer pain in therapeutic process.At this stage, cancer pain is typically based on drug therapy,
Operative treatment generally requires to consider with reference to the overall physical condition of patient and life cycle.And when using antalgesic, for
The lighter situation of pain, typically using anodyne such as aspirin, paracetamol (paracetamol), and it is directed to pain symptom
Heavier situation, then codeine, morphine etc. can be used to act on the medicine of nervous centralis, and take such medicine, though it can play
Analgesic effect, but certain injury can be caused to human central nervous, and dependence can be produced.For disadvantage mentioned above,
This Chinese medicine preparation provide no pain during a kind of use, good analgesic effect, it is without any side effects and cheap in
Medicine, can be long-term use of, will not produce dependence.Cancer pain is that the information that painful area needs to repair or adjust is passed in nerve
Caused sensation after pivot, it is one of the reason for causing cancer patients with terminal mainly painful.In pain patients, because of a variety of causes 50%
~80% pain fails to be effectively controlled.
In terms of Point of View of Clinical, the pathogenic characteristic of pain caused by cancer is simulataneous insufficiency and excessive, and " void " duty is damaged in healthy tendency, and " reality " is gas
Stagnant, blood stasis etc., treatment general provisions are strengthening vital QI to eliminate pathogenic factors, with logical analgesic.Chinese medicine cancer pain has the clinical efficacy of affirmative, in crowd
In more middle and terminal cancer patients, Chinese medicine analgesic has played huge effect.Chinese medicine analgesic effect is slow and lasting, and has nothing
The advantages that additive, drug resistance and few toxic side effect, the application of traditional Chinese medicine is greatly enriched one, two ladders (non-m orphine medicine
Thing) Pain Treatment content.So for existing pathomechanism and principle-method-recipe-medicines, need further to be deepened the understanding, improve and
Improve the Chinese medicine composition for the treatment of cancer pain.
The content of the invention
For the problems of the prior art, the invention aims to provide a kind of Chinese medicine composition for treating cancer pain
And preparation method thereof, the Chinese medicine composition prepared by this method is safe and reliable, has no toxic side effect, quick, cheap, knot
Close monarch make up a prescription mechanism carry out compatibility, there is the effect of fine to cancer pain.
In order to achieve the above object, the technical scheme is that：
A kind of Chinese medicine composition for treating cancer pain, it is characterised in that the Chinese medicine composition by following parts by weight raw material
Composition：Psoralea corylifolia 15-20 parts, pericarpium zanthoxyli 15-25 parts, asarum 3-6 parts, Chinese cassia tree 10-15 parts, monkshood 15-20 parts, cassia twig 10-15 parts,
Root of three-nerved spicebush 10-15 parts, evodia rutaecarpa 10-15 parts, fennel seeds 15-20 parts, rhizoma zingiberis 10-15 parts, peach kernel 10-15 parts, root tuber of aromatic turmeric 10-20 parts,
Fructus meliae toosendan 10-15 parts, Sculellaria barbata 10-15 parts, Paris polyphylla 10-20 parts, field pennycress 10-15 parts, Hedyotidis Diffusae 20-30 parts, rhizoma nelumbinis 15-
20 parts.
Preferably, the Chinese medicine composition is made up of the raw material of following parts by weight：It is 16 parts of psoralea corylifolia, 18 parts of pericarpium zanthoxyli, thin
Pungent 4 parts, 11 parts of Chinese cassia tree, 16 parts of monkshood, 11 parts of cassia twig, 11 parts of the root of three-nerved spicebush, 11 parts of evodia rutaecarpa, 16 parts of fennel seeds, 11 parts of rhizoma zingiberis, peach kernel
11 parts, 12 parts of root tuber of aromatic turmeric, 11 parts of Fructus meliae toosendan, 11 parts of Sculellaria barbata, 12 parts of Paris polyphylla, 11 parts of field pennycress, 22 parts of Hedyotidis Diffusae, rhizoma nelumbinis 16
Part.
Preferably, the Chinese medicine composition is made up of the raw material of following parts by weight：It is 18 parts of psoralea corylifolia, 20 parts of pericarpium zanthoxyli, thin
Pungent 5 parts, 13 parts of Chinese cassia tree, 18 parts of monkshood, 13 parts of cassia twig, 13 parts of the root of three-nerved spicebush, 13 parts of evodia rutaecarpa, 17 parts of fennel seeds, 13 parts of rhizoma zingiberis, peach kernel
13 parts, 15 parts of root tuber of aromatic turmeric, 13 parts of Fructus meliae toosendan, 13 parts of Sculellaria barbata, 15 parts of Paris polyphylla, 13 parts of field pennycress, 25 parts of Hedyotidis Diffusae, rhizoma nelumbinis 17
Part.
Preferably, the Chinese medicine composition is made up of the raw material of following parts by weight：It is 18 parts of psoralea corylifolia, 24 parts of pericarpium zanthoxyli, thin
Pungent 5 parts, 14 parts of Chinese cassia tree, 19 parts of monkshood, 14 parts of cassia twig, 14 parts of the root of three-nerved spicebush, 14 parts of evodia rutaecarpa, 19 parts of fennel seeds, 14 parts of rhizoma zingiberis, peach kernel
14 parts, 19 parts of root tuber of aromatic turmeric, 14 parts of Fructus meliae toosendan, 14 parts of Sculellaria barbata, 19 parts of Paris polyphylla, 14 parts of field pennycress, 29 parts of Hedyotidis Diffusae, rhizoma nelumbinis 29
Part.
Invention also provides a kind of preparation method of the Chinese medicine composition for the treatment of cancer pain as described above, it is special
Sign is that the preparation method comprises the following steps：
1) psoralea corylifolia, pericarpium zanthoxyli, asarum, Chinese cassia tree, monkshood, cassia twig, the root of three-nerved spicebush, evodia rutaecarpa, fennel seeds, dry, is weighed by weight
Ginger, peach kernel, root tuber of aromatic turmeric, Fructus meliae toosendan, Sculellaria barbata, Paris polyphylla, field pennycress, Hedyotidis Diffusae, rhizoma nelumbinis, screening removal of impurities, larger raw material are cut into
The fritter of soya bean size, be well mixed after under ultraviolet sterilizing lamp sterilization treatment 1 hour, be subsequently placed in container and use normal-temperature water
Soak 60-100 minutes；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow fire heats 30 points
Clock, dry in the air after being down to 50-70 DEG C to temperature, take filtrate, the dregs of a decoction in marmite are standby, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire
20 minutes, dry in the air after being down to 50-70 DEG C to temperature, filter to obtain secondary decoction；
4), the decoction obtained in step 2) and step 3) is merged, and is well mixed, bottles or packs after drying in the air to room temperature,
Obtain Traditional Chinese medicine composition liquid medicine.
The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take in three times within 1 day.Also can be 1 time
Property decoct the dose of 2 days, filling and sealing after obtained decoction is sterilized, refrigeration, first micro- heating when taking.This Chinese traditional medicine composition
Thing can also be prepared into powder capsule, and concrete scheme is as follows：
The preparation method of the Chinese medicine composition for the treatment of cancer pain as described above, it is characterised in that the preparation method includes
Following steps：
1) psoralea corylifolia, pericarpium zanthoxyli, asarum, Chinese cassia tree, monkshood, cassia twig, the root of three-nerved spicebush, evodia rutaecarpa, fennel seeds, dry, is weighed by weight
Ginger, peach kernel, root tuber of aromatic turmeric, Fructus meliae toosendan, Sculellaria barbata, Paris polyphylla, field pennycress, Hedyotidis Diffusae, rhizoma nelumbinis, screening removal of impurities, larger raw material are cut into
The fritter of soya bean size, after being well mixed under ultraviolet sterilizing lamp sterilization treatment 1 hour, be then ground to powder, cross 500-800
After mesh sieve point, herb powder is obtained；
2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
Further, the preparation method 1) granularity of herb powder that obtains in step is 600 mesh.
The Chinese medicine composition of the present invention has no toxic side effect, and therapeutic effect is good, treats both principal and secondary aspect of disease, uneasy to recur, and cancer pain has
Good analgesic effect.
The Chinese medicine composition can be prepared into the diversified forms such as Chinese medicinal tablet, particle, traditional Chinese medicine pill, be not limited to decoction and
Capsule, suitable for a variety of therapeutic modalities, application method.
The pharmacology of all kinds of Chinese medicines is as follows in the present invention：
Psoralea corylifolia：It is pungent, bitter, warm-natured, enter kidney channel, pericardium channel, the spleen channel, stomach, lung channel.Effect：Tonify the kidney and support yang.For kidney deficiency
Cold to rush down, the enuresis, involuntary emission, frequent urination, impotence, waist and knee crymodynia, the cold of insufficiency type, which is breathed heavily, coughs, external application curing vitiligo.
Pericarpium zanthoxyli：It is pungent, warm, enter spleen, stomach, kidney channel.Effect：Warm in pain, removing dampness and destroying parasites.For coldness and pain in the epigastrium, vomiting and diarrhea,
Abdominal pain due to enterositosis；Control eczema, pruritus vulvae outside.
Asarum：It is pungent, warm, enter the heart, lung, kidney channel.Effect：Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, Wenfei of drink.For chill
Flu, have a headache, toothache, arthralgia pain due to rheumatism, nasosinusitis, lung cold cough.
Chinese cassia tree：Pungent, sweet, extremely hot in nature, enter kidney, spleen, the heart, Liver Channel.Effect：Mends fire supporing yang, guiding fire to origin, eliminating cold to stop pain, temperature
Qualcomm meridian.For impotence Gong Leng, waist and knee crymodynia, deficiency of the kidney and dyspnea, deficient yang with upper manifestation, dizziness hot eyes, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, tremble with fear
Hernia is suffered from abdominal pain, dysmenorrhoea Amenorrhea.
Monkshood：Pungent, sweet, extremely hot in nature, enter the heart, kidney, the spleen channel.Effect：Recuperating depleted yang, mends fire supporing yang, eliminating cold to stop pain.For dying
The deficiency of yang takes off, cold weak pulse of limb, deficiency of heart-YANG, chest impediment and cardialgia, cold of insufficiency type vomiting and diarrhea, coldness and pain in the epigastrium, decline of kidney-YANG, impotence Gong Leng, cold sensation of the genitalia water
It is swollen, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.
Cassia twig：It is pungent, sweet, warm-natured, enter lung, the heart, bladder warp.Effect：Inducing sweat and dispelling exogenous evils, eliminating cold to stop pain, activating YANG and prormoting functioning of QI.For wind
Cold flu, all pains of congealing cold with blood stasis, phlegm and retained fluid, blood stagnation syndrome, palpitaition.
The root of three-nerved spicebush：It is pungent, warm, enter lung, spleen, kidney, bladder warp.Effect：Promoting qi circulation and relieving pain, warming kidney for dispelling cold.For cold obstruction causing qi stagnation, chest and abdomen
Distending pain, circulation of vital energy in the wrong direction asthma is anxious, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia pain, through cold stomachache.
Evodia rutaecarpa：It is pungent, bitter, property is hot, enter liver, spleen, stomach, kidney channel.Effect：Eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.With
In jueyin headache, cold hernia stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal distention, acid regurgitation, Diarrhoea are vomitted.
Fennel seeds：It is pungent, warm-natured, enter liver,kidney,spleen, stomach.Effect：Eliminating cold to stop pain, regulating qi-flowing for harmonizing stomach.For cold hernia stomachache, testis
The ball swelling and hanging down of either of the testes, dysmenorrhoea, few abdomen crymodynia, abdominal distention, deficiency of food are vomited and diarrhoea.
Rhizoma zingiberis：It is pungent, property is hot, enter spleen, stomach, kidney, the heart, lung channel.Effect：Warming spleen and stomach for dispelling cold, Back to Yang Tongmai, Wenfei of drink.For
Coldness and pain in the epigastrium, vomiting and diarrhea, cold weak pulse of limb, cold drink are breathed with cough.
Peach kernel：It is bitter, sweet, flat, enter the heart, liver, large intestine channel.Effect：Promoting blood circulation, relax bowel, it is relieving cough and asthma.For Amenorrhea
Dysmenorrhoea, lump in the abdomen lump in the abdomen lump in the abdomen, lung carbuncle acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma.
Root tuber of aromatic turmeric：It is pungent, bitter, cold, enter liver, the heart, lung channel.Effect：Promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, clear away heart-fire cool blood, normalizing gallbladder to cure jaundice.
Gone mad for chest side of body shouting pain, chest impediment and cardialgia, closed dysmenorrhea, swollen breasts, pyreticosis coma, epilepsy, blood-head tells nosebleed, jaundice.
Fructus meliae toosendan：It is bitter, cold, enter liver, small intestine, bladder warp.Effect：It is soothing the liver to expel the heat-evil, promoting qi circulation and relieving pain, desinsection.For liver depression
Fire, chest side of body, abdominal distention, hernia pain, abdominal pain due to enterositosis.
Sculellaria barbata：It is pungent, bitter, cold in nature, enter lung, liver and kidney channel.Effect：It is clearing heat and detoxicating, stagnation resolvation diuresis.For furuncle swelling toxin, pharynx
Larynx swells and ache, the pain of injury caused by falling and tumbling, oedema, jaundice, snake bite and insect sting.
Paris polyphylla：Hardship, it is slightly cold, is slightly poisonous, enters Liver Channel.Effect：It is clearing heat and detoxicating, swelling and pain relieving, cool liver arresting convulsion.For furunculosis carbuncle
It is swollen, abscess of throat, snake bite and insect sting, the pain of injury caused by falling and tumbling, convulsion.
Field pennycress：It is pungent, bitter, cool, enter liver, stomach, large intestine channel.Effect：It is clearing heat and detoxicating, eliminating the phlegm apocenosis.For acute appendicitis, lung carbuncle,
Dysentery, postpartum blood stasis stomachache, carbuncle swells furunculosis.
Hedyotidis Diffusae：It is bitter, sweet, cold, enter the heart, liver, spleen, large intestine channel.Effect：It is clearing heat and detoxicating, dampness removing.For dyspnea and cough due to lung-heat,
Abscess of throat, acute appendicitis, furuncle sore, venomous snake bite, puckery pain of heat gonorrhea, oedema, dysentery, enteritis, jaundice with damp-heat pathogen, cancerous swelling.
Rhizoma nelumbinis：It is sweet, puckery, flat, enter liver, lung, stomach.Effect：Astringing to arrest bleeding, stagnation resolvation.For spitting blood, spitting of blood, bleeding from five sense organs or subcutaneous tissue, urine
Blood, uterine bleeding.
" organic conception " is had been accepted as at present, " diagnosis and treatment based on an overall analysis of the illness and the patient's condition ", " compound use ", " compound compatibility medication is such as used military forces " are the traditional Chinese medical science
Most scientific maximally effective several big advantages, wherein " compound compatibility medication is such as used military forces " is the original theory of traditional Chinese medicine of very science.In
The tight compatibility that each medicine is all linked with one another as arraying troops for battle in prescription is cured, is that it is better than the effective means of western medicine formula.The traditional Chinese medical science
Prescription theory thinks, each prescription, not only needs to select the suitable appropriate compatibility of medicine according to etiology and pathogenesis, while should also accord with
Close the prescription compatibility theory of the basic structure of prescription, i.e. " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make ", just
It is that it establishes the scientific matching on the comprehensive judgement basis to the disease interpretation of the cause, onset and process of an illness.Middle medical square is whole by too many levels, Mutiple Targets
The biological mechanism of regulation is closed, therapeutic effect more more longlasting than Western medicine, that more green natural has no toxic side effect can be obtained, and it is this
Curative effect is built upon on the original theoretical accurate instruction of above-mentioned traditional Chinese medical science tradition, and the present invention just have followed this principle.
Monarch drug in a prescription treats primary symptom in the side of referring to, plays the medicine of primary treatment, can use as required simply or a few taste medicines.Minister
Medicine is the medicine assisted main ingredient or strengthen main ingredient effect.Adjutant is the medicine for the toxicity assisted main ingredient treatment and disease or suppress main ingredient
Thing.Make the effect that medicine is the through diseased region of each medicine of guiding or each medicine of mediation.
The present invention is using kidney-nourishing and yang-supporting fructus psoraleae as monarch drug in a prescription, with the pericarpium zanthoxyli of warm in pain and relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping
Asarum is ministerial drug, inverse with the Chinese cassia tree of mends fire supporing yang, the monkshood of eliminating cold to stop pain, the cassia twig of inducing sweat and dispelling exogenous evils, the root of three-nerved spicebush of promoting qi circulation and relieving pain, drop
The evodia rutaecarpa of preventing or arresting vomiting, the fennel seeds of regulating qi-flowing for harmonizing stomach, the rhizoma zingiberis of warming spleen and stomach for dispelling cold, the peach kernel of promoting blood circulation, promoting blood circulation and stopping pain root tuber of aromatic turmeric, dredge
Fructus meliae toosendan that liver expels the heat-evil, clearing heat and detoxicating Sculellaria barbata, the Paris polyphylla of swelling and pain relieving, the field pennycress of eliminating the phlegm apocenosis, clearing heat and detoxicating, dampness removing
Hedyotidis Diffusae be adjutant, with astringing to arrest bleeding, the rhizoma nelumbinis of stagnation resolvation is makes medicine, and formula is reasonable, for cancer pain, from overall regulation and control
Angle is started with carries out conditioning and treating by number of ways, warm in pain, tonify the kidney and support yang, warming meridian, promoting qi circulation and relieving pain, promoting blood circulation are dispelled
The stasis of blood, evident in efficacy, safe without toxic side effect, it is adapted to long-term use.
The Chinese medicine of the present invention passes through a large amount of clinical verifications, can improve patients ' life quality and immunologic function, safe,
It is curative for effect, be worthy to be popularized.Existing with the obvious advantage in the clinical practice for the treatment of cancer pain, development and application from now on also have extensively
Wealthy prospect.
Embodiment
The present invention is further described with reference to embodiment.
Embodiment one：
A kind of Chinese medicine composition for treating cancer pain, it is characterised in that the Chinese medicine is made up of the raw material of following parts by weight：
It is 15 parts of psoralea corylifolia, 15 parts of pericarpium zanthoxyli, 3 parts of asarum, 10 parts of Chinese cassia tree, 15 parts of monkshood, 10 parts of cassia twig, 10 parts of the root of three-nerved spicebush, 10 parts of evodia rutaecarpa, small
15 parts of fennel, 10 parts of rhizoma zingiberis, 10 parts of peach kernel, 10 parts of root tuber of aromatic turmeric, 10 parts of Fructus meliae toosendan, 10 parts of Sculellaria barbata, 10 parts of Paris polyphylla, field pennycress 10
Part, 20 parts of Hedyotidis Diffusae, 15 parts of rhizoma nelumbinis.
The present embodiment also discloses a kind of preparation method of the Chinese medicine composition for the treatment of cancer pain as described above, its
It is characterised by that the preparation method comprises the following steps：
1) 15 parts of psoralea corylifolia, 15 parts of pericarpium zanthoxyli, 3 parts of asarum, 10 parts of Chinese cassia tree, 15 parts of monkshood, cassia twig 10, are weighed by weight
Part, 10 parts of the root of three-nerved spicebush, 10 parts of evodia rutaecarpa, 15 parts of fennel seeds, 10 parts of rhizoma zingiberis, 10 parts of peach kernel, 10 parts of root tuber of aromatic turmeric, 10 parts, half of Fructus meliae toosendan
10 parts of lotus, 10 parts of Paris polyphylla, 10 parts of field pennycress, 20 parts of Hedyotidis Diffusae, 15 parts of rhizoma nelumbinis, screening removal of impurities, larger raw material are cut into soya bean
The fritter of size, be well mixed after under ultraviolet sterilizing lamp sterilization treatment 1 hour, be subsequently placed in container and soaked with normal-temperature water
60 minutes；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow fire heats 30 points
Clock, dry in the air after being down to 50 DEG C to temperature, take filtrate, the dregs of a decoction in marmite are standby, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire
20 minutes, dry in the air after being down to 50 DEG C to temperature, filter to obtain secondary decoction；
4), the decoction obtained in step 2) and step 3) is merged, and is well mixed, bottles or packs after drying in the air to room temperature,
Obtain Traditional Chinese medicine composition liquid medicine.
Embodiment two
A kind of Chinese medicine composition for treating cancer pain, it is characterised in that the Chinese medicine composition by following parts by weight raw material
Composition：20 parts of psoralea corylifolia, 25 parts of pericarpium zanthoxyli, 6 parts of asarum, 15 parts of Chinese cassia tree, 20 parts of monkshood, 15 parts of cassia twig, 15 parts of the root of three-nerved spicebush, evodia rutaecarpa 15
Part, 20 parts of fennel seeds, 15 parts of rhizoma zingiberis, 15 parts of peach kernel, 20 parts of root tuber of aromatic turmeric, 15 parts of Fructus meliae toosendan, 15 parts of Sculellaria barbata, 20 parts of Paris polyphylla, Patrinia scaniosaefolia
15 parts of grass, 30 parts of Hedyotidis Diffusae, 20 parts of rhizoma nelumbinis.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of cancer pain as described above simultaneously, its
It is characterised by that the preparation method comprises the following steps：
1) 20 parts of psoralea corylifolia, 25 parts of pericarpium zanthoxyli, 6 parts of asarum, 15 parts of Chinese cassia tree, 20 parts of monkshood, cassia twig 15, are weighed by weight
Part, 15 parts of the root of three-nerved spicebush, 15 parts of evodia rutaecarpa, 20 parts of fennel seeds, 15 parts of rhizoma zingiberis, 15 parts of peach kernel, 20 parts of root tuber of aromatic turmeric, 15 parts, half of Fructus meliae toosendan
15 parts of lotus, 20 parts of Paris polyphylla, 15 parts of field pennycress, 30 parts of Hedyotidis Diffusae, 20 parts of rhizoma nelumbinis, screening removal of impurities, larger raw material are cut into soya bean
The fritter of size, after being well mixed under ultraviolet sterilizing lamp sterilization treatment 1 hour, be then ground to powder, cross 500 mesh sieves point
Afterwards, herb powder is obtained；
2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
Embodiment three：
A kind of Chinese medicine composition for treating cancer pain, it is characterised in that the Chinese medicine composition by following parts by weight raw material
Composition：16 parts of psoralea corylifolia, 18 parts of pericarpium zanthoxyli, 4 parts of asarum, 11 parts of Chinese cassia tree, 16 parts of monkshood, 11 parts of cassia twig, 11 parts of the root of three-nerved spicebush, evodia rutaecarpa 11
Part, 16 parts of fennel seeds, 11 parts of rhizoma zingiberis, 11 parts of peach kernel, 12 parts of root tuber of aromatic turmeric, 11 parts of Fructus meliae toosendan, 11 parts of Sculellaria barbata, 12 parts of Paris polyphylla, Patrinia scaniosaefolia
11 parts of grass, 22 parts of Hedyotidis Diffusae, 16 parts of rhizoma nelumbinis.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of cancer pain as described above simultaneously, its
It is characterised by that the preparation method comprises the following steps：
1) 16 parts of psoralea corylifolia, 18 parts of pericarpium zanthoxyli, 4 parts of asarum, 11 parts of Chinese cassia tree, 16 parts of monkshood, cassia twig 11, are weighed by weight
Part, 11 parts of the root of three-nerved spicebush, 11 parts of evodia rutaecarpa, 16 parts of fennel seeds, 11 parts of rhizoma zingiberis, 11 parts of peach kernel, 12 parts of root tuber of aromatic turmeric, 11 parts, half of Fructus meliae toosendan
11 parts of lotus, 12 parts of Paris polyphylla, 11 parts of field pennycress, 22 parts of Hedyotidis Diffusae, 16 parts of rhizoma nelumbinis, screening removal of impurities, larger raw material are cut into soya bean
The fritter of size, be well mixed after under ultraviolet sterilizing lamp sterilization treatment 1 hour, be subsequently placed in container and soaked with normal-temperature water
80 minutes；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow fire heats 30 points
Clock, dry in the air after being down to 60 DEG C to temperature, take filtrate, the dregs of a decoction in marmite are standby, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire
20 minutes, dry in the air after being down to 60 DEG C to temperature, filter to obtain secondary decoction；
4), the decoction obtained in step 2) and step 3) is merged, and is well mixed, bottles or packs after drying in the air to room temperature,
Obtain Traditional Chinese medicine composition liquid medicine.
Example IV：
A kind of Chinese medicine composition for treating cancer pain, it is characterised in that the Chinese medicine composition by following parts by weight raw material
Composition：18 parts of psoralea corylifolia, 20 parts of pericarpium zanthoxyli, 5 parts of asarum, 13 parts of Chinese cassia tree, 18 parts of monkshood, 13 parts of cassia twig, 13 parts of the root of three-nerved spicebush, evodia rutaecarpa 13
Part, 17 parts of fennel seeds, 13 parts of rhizoma zingiberis, 13 parts of peach kernel, 15 parts of root tuber of aromatic turmeric, 13 parts of Fructus meliae toosendan, 13 parts of Sculellaria barbata, 15 parts of Paris polyphylla, Patrinia scaniosaefolia
13 parts of grass, 25 parts of Hedyotidis Diffusae, 17 parts of rhizoma nelumbinis.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of cancer pain as described above simultaneously, its
It is characterised by that the preparation method comprises the following steps：
1) 18 parts of psoralea corylifolia, 20 parts of pericarpium zanthoxyli, 5 parts of asarum, 13 parts of Chinese cassia tree, 18 parts of monkshood, cassia twig 13, are weighed by weight
Part, 13 parts of the root of three-nerved spicebush, 13 parts of evodia rutaecarpa, 17 parts of fennel seeds, 13 parts of rhizoma zingiberis, 13 parts of peach kernel, 15 parts of root tuber of aromatic turmeric, 13 parts, half of Fructus meliae toosendan
13 parts of lotus, 15 parts of Paris polyphylla, 13 parts of field pennycress, 25 parts of Hedyotidis Diffusae, 17 parts of rhizoma nelumbinis, screening removal of impurities, larger raw material are cut into soya bean
The fritter of size, after being well mixed under ultraviolet sterilizing lamp sterilization treatment 1 hour, be then ground to powder, cross 600 mesh sieves point
Afterwards, herb powder is obtained；
2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
Embodiment five：
A kind of Chinese medicine composition for treating cancer pain, it is characterised in that the Chinese medicine composition by following parts by weight raw material
Composition：18 parts of psoralea corylifolia, 24 parts of pericarpium zanthoxyli, 5 parts of asarum, 14 parts of Chinese cassia tree, 19 parts of monkshood, 14 parts of cassia twig, 14 parts of the root of three-nerved spicebush, evodia rutaecarpa 14
Part, 19 parts of fennel seeds, 14 parts of rhizoma zingiberis, 14 parts of peach kernel, 19 parts of root tuber of aromatic turmeric, 14 parts of Fructus meliae toosendan, 14 parts of Sculellaria barbata, 19 parts of Paris polyphylla, Patrinia scaniosaefolia
14 parts of grass, 29 parts of Hedyotidis Diffusae, 29 parts of rhizoma nelumbinis.
The present embodiment provides a kind of preparation method of the Chinese medicine composition for the treatment of cancer pain as described above simultaneously, its
It is characterised by that the preparation method comprises the following steps：
1) 18 parts of psoralea corylifolia, 24 parts of pericarpium zanthoxyli, 5 parts of asarum, 14 parts of Chinese cassia tree, 19 parts of monkshood, cassia twig 14, are weighed by weight
Part, 14 parts of the root of three-nerved spicebush, 14 parts of evodia rutaecarpa, 19 parts of fennel seeds, 14 parts of rhizoma zingiberis, 14 parts of peach kernel, 19 parts of root tuber of aromatic turmeric, 14 parts, half of Fructus meliae toosendan
14 parts of lotus, 19 parts of Paris polyphylla, 14 parts of field pennycress, 29 parts of Hedyotidis Diffusae, 29 parts of rhizoma nelumbinis, screening removal of impurities, larger raw material are cut into soya bean
The fritter of size, be well mixed after under ultraviolet sterilizing lamp sterilization treatment 1 hour, be subsequently placed in container and soaked with normal-temperature water
80 minutes；
2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow fire heats 30 points
Clock, dry in the air after being down to 70 DEG C to temperature, take filtrate, the dregs of a decoction in marmite are standby, and filtrate is poured into container；
3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire
20 minutes, dry in the air after being down to 70 DEG C to temperature, filter to obtain secondary decoction；
4), the decoction obtained in step 2) and step 3) is merged, and is well mixed, bottles or packs after drying in the air to room temperature,
Obtain Traditional Chinese medicine composition liquid medicine.
The present invention has carried out clinical efficacy tracking with the data given by embodiment 1 simultaneously, and curative effect is summarized as follows：
1. selecting canurous ache patients 100, age 35-65 year, average age 50 years old, patient is randomly divided into two groups, controlled
There was no significant difference for the data such as treatment group 50, control group 50, two groups of ages, has comparativity.All selected patients are through pathology
The middle and advanced stage malignant tumor patient that or cytology are made a definite diagnosis, and in, severe pain, need drug therapy person；It is non-to exclude other
Cancer pain factor；Ability of language expression is normal, there is judgement to itself pain and general status, and can cooperation evaluation pain
And quality of life content etc.；Without drug abuse history；Subject is fully understood by participating in the benefit of experiment and risk, is voluntary, controls
Treat and coordinate.
2. treatment method, the oral Chinese medicine composition made from optimization formula embodiment 1 of the present invention for the treatment of group, per bu sooner or later
Take twice, the course for the treatment of 8 days.The oral basic medicine of control group, according to dosage takes with number daily, the course for the treatment of 8 days.
3. diagnostic criteria
All cases meet what State Administration of Traditional Chinese Medicine issued《Chinese medical disease diagnostic criteria》In diagnostic criteria.Ginseng
According to《New Chinese medicine guideline of clinical investigations》Relevant criterion is worked out.
Cure:The symptom of cancer pain is disappeared, and quality of life is improved；
It is effective:Cancer pain symptom substantially mitigates；
Effectively:Cancer pain symptom slightly mitigates；
It is invalid:Symptom after taking medicine sign is without improvement or improves unobvious.
4. treatment results, the cure rate for the treatment of group is 65%, effective 15%, effective 10%, invalid 10%, total effective rate
90%；The cure rate of control group is 20%, effective 18%, effective 22%, invalid 40%, total effective rate 60%.
As a result show, Chinese medicine preparation of the invention, can effectively adjust organism quality, there is analgesic effect well to cancer pain
Fruit, for treat cancer pain have the advantages that it is curative for effect, cheap, have no side effect, cure rate it is high uneasy to recur, be worth
Clinical application.
The Chinese medicine of the present invention has carried out toxicity test, and test effect is as follows：
To choose that the suitable adult of body weight is female, male each 20 of small white mouse, be divided into control group and administration group, rearing conditions are consistent,
Control group not medicine feed, the daily medicine feed of administration group 1 time, records the health of each small white mouse, ingests, drinks water, body weight daily, tries
Test lasting six months, compared with control group, administration group small white mouse health, ingest, drink water, body weight increase it is normal, and not
See that small white mouse is sick or dead.Prompt the medicine security good, have no toxic side effect.
The treatment case of the Chinese medicine of the present invention is as follows：
Case one, week certain, man, 65 years old.Nasopharyngeal Carcinoma Patients, rear cancer cell oppress brachial plexus and neck god to cervical metastasis
Through clump, cause neck, shoulder, arm part pain.After take this medicine after 10 days above-mentioned symptom alleviated, above-mentioned disease after 2 months
Shape disappears, and the above-mentioned pain symptom so far that is discontinued does not recur.
Case two, Mr. Wang, female, 57 years old.Cause pain in oncotherapy, actinonerritis, stomatitis, skin occur
The symptoms such as inflammation, osteordionecrosis.Occur herpes zoster after radiotherapy, chemotherapy and produce pain.Multi-party medication effect unobvious, rear clothes
With symptom mitigation after this medicine 15 days, above-mentioned symptom disappears after continuing medication 2 months, and above-mentioned symptom does not recur so far.
Case three, Mr. Wang, male, 61 years old, occurred Abdeminal pain sense before half a year, hepatic region dull pain, body weight progressive mitigates, with weary
Power.Abdominal ultrasonic and CT examination prompting：Right lobe of the liver, which is shown in, 7cm × 7cm and 4cm × 4cm tubercles, moderate hepatic sclerosis, alpha-fetoprotein
Detection is positive.Through case through check pathological section, primary carcinoma of liver is diagnosed as.Patient refuses operation, is intended to expectant treatment.Symptoms include face
Color is dark, hepatic region paroxysmal dull pain, epigastric fullness and rigidity, and abdominal distension is not eaten, tired mind, dry and hard excrement.Crimson tongue without fur, the thin chord number of arteries and veins.
Tcm diagnosis is：Liver ruffian, card type category qi depression to blood stasis.The capsule product for giving medicine of the present invention five a time, 1 day 3 times, is treated 10 days
Afterwards, pain has been alleviated, and further consultation after January, pain is resistant to during readme medication, and appetite is promoted.
It is understood that above with respect to the specific descriptions of the present invention, it is merely to illustrate the present invention and is not limited to this
Technical scheme described by inventive embodiments, it will be understood by those within the art that, still the present invention can be carried out
Modification or equivalent substitution, to reach identical technique effect；As long as meet use needs, all protection scope of the present invention it
It is interior.
Claims (7)
- A kind of 1. Chinese medicine composition for treating cancer pain, it is characterised in that the Chinese medicine composition by following parts by weight raw material group Into：Psoralea corylifolia 15-20 parts, pericarpium zanthoxyli 15-25 parts, asarum 3-6 parts, Chinese cassia tree 10-15 parts, monkshood 15-20 parts, cassia twig 10-15 parts, crow Medicine 10-15 parts, evodia rutaecarpa 10-15 parts, fennel seeds 15-20 parts, rhizoma zingiberis 10-15 parts, peach kernel 10-15 parts, root tuber of aromatic turmeric 10-20 parts, river Chinaberry 10-15 parts, Sculellaria barbata 10-15 parts, Paris polyphylla 10-20 parts, field pennycress 10-15 parts, Hedyotidis Diffusae 20-30 parts, rhizoma nelumbinis 15-20 Part.
- A kind of 2. Chinese medicine composition for treating cancer pain according to claim 1, it is characterised in that the Chinese medicine composition It is made up of the raw material of following parts by weight：16 parts of psoralea corylifolia, 18 parts of pericarpium zanthoxyli, 4 parts of asarum, 11 parts of Chinese cassia tree, 16 parts of monkshood, cassia twig 11 Part, 11 parts of the root of three-nerved spicebush, 11 parts of evodia rutaecarpa, 16 parts of fennel seeds, 11 parts of rhizoma zingiberis, 11 parts of peach kernel, 12 parts of root tuber of aromatic turmeric, 11 parts, half of Fructus meliae toosendan 11 parts of lotus, 12 parts of Paris polyphylla, 11 parts of field pennycress, 22 parts of Hedyotidis Diffusae, 16 parts of rhizoma nelumbinis.
- A kind of 3. Chinese medicine composition for treating cancer pain according to claim 1, it is characterised in that the Chinese medicine composition It is made up of the raw material of following parts by weight：18 parts of psoralea corylifolia, 20 parts of pericarpium zanthoxyli, 5 parts of asarum, 13 parts of Chinese cassia tree, 18 parts of monkshood, cassia twig 13 Part, 13 parts of the root of three-nerved spicebush, 13 parts of evodia rutaecarpa, 17 parts of fennel seeds, 13 parts of rhizoma zingiberis, 13 parts of peach kernel, 15 parts of root tuber of aromatic turmeric, 13 parts, half of Fructus meliae toosendan 13 parts of lotus, 15 parts of Paris polyphylla, 13 parts of field pennycress, 25 parts of Hedyotidis Diffusae, 17 parts of rhizoma nelumbinis.
- A kind of 4. Chinese medicine composition for treating cancer pain according to claim 1, it is characterised in that the Chinese medicine composition It is made up of the raw material of following parts by weight：18 parts of psoralea corylifolia, 24 parts of pericarpium zanthoxyli, 5 parts of asarum, 14 parts of Chinese cassia tree, 19 parts of monkshood, cassia twig 14 Part, 14 parts of the root of three-nerved spicebush, 14 parts of evodia rutaecarpa, 19 parts of fennel seeds, 14 parts of rhizoma zingiberis, 14 parts of peach kernel, 19 parts of root tuber of aromatic turmeric, 14 parts, half of Fructus meliae toosendan 14 parts of lotus, 19 parts of Paris polyphylla, 14 parts of field pennycress, 29 parts of Hedyotidis Diffusae, 29 parts of rhizoma nelumbinis.
- 5. a kind of preparation method of the Chinese medicine composition for the treatment of cancer pain as any one of claim 1-4, it is special Sign is that the preparation method comprises the following steps：1) psoralea corylifolia, pericarpium zanthoxyli, asarum, Chinese cassia tree, monkshood, cassia twig, the root of three-nerved spicebush, evodia rutaecarpa, fennel seeds, rhizoma zingiberis, peach, are weighed by weight Benevolence, root tuber of aromatic turmeric, Fructus meliae toosendan, Sculellaria barbata, Paris polyphylla, field pennycress, Hedyotidis Diffusae, rhizoma nelumbinis, screening removal of impurities, it is big that larger raw material is cut into soya bean Small fritter, be well mixed after under ultraviolet sterilizing lamp sterilization treatment 1 hour, be subsequently placed in container and soaked with normal-temperature water 60-100 minutes；2), the Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow fire heats 30 minutes, dries in the air After being down to 50-70 DEG C to temperature, filtrate is taken, the dregs of a decoction in marmite are standby, and filtrate is poured into container；3), hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 20 points Clock, dry in the air after being down to 50-70 DEG C to temperature, filter to obtain secondary decoction；4), the decoction obtained in step 2) and step 3) is merged, and is well mixed, bottles or packs after drying in the air to room temperature, in obtaining Drug composition decoction.
- 6. a kind of preparation method of the Chinese medicine composition for the treatment of cancer pain as any one of claim 1-4, it is special Sign is that the preparation method comprises the following steps：1) psoralea corylifolia, pericarpium zanthoxyli, asarum, Chinese cassia tree, monkshood, cassia twig, the root of three-nerved spicebush, evodia rutaecarpa, fennel seeds, rhizoma zingiberis, peach, are weighed by weight Benevolence, root tuber of aromatic turmeric, Fructus meliae toosendan, Sculellaria barbata, Paris polyphylla, field pennycress, Hedyotidis Diffusae, rhizoma nelumbinis, screening removal of impurities, it is big that larger raw material is cut into soya bean Small fritter, after being well mixed under ultraviolet sterilizing lamp sterilization treatment 1 hour, be then ground to powder, cross 500-800 mesh sieves point Afterwards, herb powder is obtained；2), the herb powder for obtaining step 1), which is fitted into capsule skin, is made Chinese medicinal capsule.
- 7. the preparation method of a kind of Chinese medicine composition for treating cancer pain according to claim 6, it is characterised in that should Preparation method 1) granularity of herb powder that obtains in step is 600 mesh.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109821002A (en) * | 2018-12-20 | 2019-05-31 | 徐芃芃 | A kind of Chinese herbs paste suitable for cancer pain |
| CN115054664A (en) * | 2022-07-25 | 2022-09-16 | 北京康恩泰生物医药有限公司 | A pharmaceutical composition for treating cancer pain, and its preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109821002A (en) * | 2018-12-20 | 2019-05-31 | 徐芃芃 | A kind of Chinese herbs paste suitable for cancer pain |
| CN115054664A (en) * | 2022-07-25 | 2022-09-16 | 北京康恩泰生物医药有限公司 | A pharmaceutical composition for treating cancer pain, and its preparation method |
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Application publication date: 20180327 |