CN107823301A - A kind of external medicinal liquid for treating onychomycosis and preparation method thereof - Google Patents
A kind of external medicinal liquid for treating onychomycosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of external medicinal liquid for treating onychomycosis and preparation method thereof, belongs to onychomycosis treatment technology field.The external medicinal liquid of the treatment onychomycosis, by decoction A and medical liquid B by weight 1:(2 4) form, wherein, the decoction A is made up of the raw material of following parts by weight：40 60 parts of salicylic acid, 180 220 parts of glacial acetic acid and mass concentration are 70% 700 800 parts of ethanol solution, and the medical liquid B is made up of the raw material of following parts by weight：80 120 parts of 250 350 parts of coptis ethanol extract, 80 120 parts of golden cypress ethanol extract and radix scutellariae ethanol extract.The invention also discloses the preparation method of the external medicinal liquid of above-mentioned treatment onychomycosis.The external medicinal liquid of the treatment onychomycosis of the present invention, can effectively treat onychomycosis, and treatment time is short, curative effect is high, have no side effect, be easy to use, cost is low, thorough elimination, does not recur.
Description
Technical field
The present invention relates to a kind of external medicinal liquid for treating onychomycosis and preparation method thereof, belongs to onychomycosis treatment technology neck
Domain.
Background technology
Ash refers to (toe) first, medically also known as onychomycosis, is to be attacked by fungi and cause fingers (toe) first to infect and the lesion of generation.
Clinical manifestation is nail body deformation, thickening, uneven, nail body is coarse, matt or discoloration, nail body incompleteness etc..The onychomycosis incidence of disease
Height, infectiousness is strong, and onychomycosis not only influences brothers' outward appearance, can also cause the tinea manuum, tinea pedis, ringworm of the body and other fungal infectious diseases
Disease.
In the prior art, treating the medicine of onychomycosis has oral medicine, injecting drug use and externally applied drug.Wherein, oral medicine with
And injecting drug use, such as terbinafine, Itraconazole, Fluconazole, mostly external import medicine, course for the treatment of length, expensive, pair is made
With big, a certain degree of infringement of liver and kidney to patient.Externally applied drug, such as bright first, Terbinafine tincture, Amorolfine first are put on the skin
Agent, Ciclopirox Olamine ketone first paint, whitfield ointment, Miconazole creme, compound thunder lock pungent preparation etc., kill dermatophyte work
With, but need patient first to be filed with warm water or vinegar by sick first maceration, then with first by sick first wear down, then coating, also wants package.Step
It is cumbersome, make patient be pestered beyond endurance, and easily cause and injure skin injury, infection outside.If patient's improper use, in fact it could happen that
Skin is thicker, swelling, bubble or decortication, allergic person can't use.And medicine irritation is strong, there is insufferable pain
Bitterly, it is necessary to which long-term coating can just work, cure the symptoms, not the disease, high recurrence rate.
In consideration of it, it is necessary to research and develop a kind of medicine of new treatment onychomycosis, to solve the deficiencies in the prior art.
The content of the invention
An object of the present invention, it is to provide a kind of external medicinal liquid for treating onychomycosis.The treatment onychomycosis of the present invention
External medicinal liquid, onychomycosis can be effectively treated, treatment time is short, curative effect is high, have no side effect, be easy to use, cost is low, thorough root
Remove, do not recur.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of external medicinal liquid for treating onychomycosis, by decoction A
With medical liquid B by weight 1:(2-4) is formed, wherein, the decoction A is made up of the raw material of following parts by weight：Salicylic acid 40-60
Part, glacial acetic acid 180-220 parts and mass concentration are 70% ethanol solution 700-800 parts, and the medical liquid B is by following parts by weight
Raw material be made：Coptis ethanol extract 250-350 parts, golden cypress ethanol extract 80-120 parts and radix scutellariae ethanol extract 80-
120 parts, wherein, the coptis ethanol extract comprises the following steps：The dry coptis is crushed, being immersed in mass concentration is
In 70% ethanol solution, 22-26h is extracted in 45-55 DEG C, after centrifugation, is concentrated under reduced pressure, then with the second that mass concentration is 70%
Alcoholic solution, the concentration of regulation coptis ethanol extract is 1.0-2.0g/mL；
The golden cypress ethanol extract comprises the following steps：Dry golden cypress is crushed, being immersed in mass concentration is
In 70% ethanol solution, 22-26h is extracted in 45-55 DEG C, after centrifugation, is concentrated under reduced pressure, then with the second that mass concentration is 70%
Alcoholic solution, the concentration of regulation golden cypress ethanol extract is 1.0-2.0g/mL；
The radix scutellariae ethanol extract comprises the following steps：Dry radix scutellariae is crushed, being immersed in mass concentration is
In 70% ethanol solution, 22-26h is extracted in 45-55 DEG C, after centrifugation, is concentrated under reduced pressure, then with the second that mass concentration is 70%
Alcoholic solution, the concentration of regulation radix scutellariae ethanol extract is 1.0-2.0g/mL.
The effect of raw material of the present invention, is as follows：
1st, the coptis
The coptis, be the ranunculaceae plant coptis, the triangle leaf coptis and Yun Lian dry rhizome, bitter is cold in nature, the thoughts of returning home, spleen,
Stomach, liver, courage, large intestine channel, there are purging intense heat, removing toxic substances, heat-clearing, eliminating dampness.It contains a variety of alkaloids, mainly jamaicin (again
Referred to as berberine), content is up to 3.6%, is secondly coptisine, jateorrhizine and worenine.
2nd, golden cypress
Golden cypress, it is the drying branch of rutaceae wampee, bitter is cold in nature, returns kidney, bladder warp, has heat-clearing and damp-drying drug, rushes down
The effect of fire dehumidifying, detoxification sore treatment.Its main component is jamaicin, can suppress the growth and breeding of bacterium, and has the anti-true of uniqueness
Bacterium acts on.
3rd, radix scutellariae
Radix scutellariae, it is the dry root of labiate radix scutellariae, bitter is cold in nature, return lung, courage, spleen, large intestine, small intestinl channel.It is anti-true
The effective ingredient of bacterium is scutelloside, and effectively substantially the effect of anti-Bai Jinzhu bacterium, its mechanism may be by pressing down scutelloside in vitro
DNA, RNA and protein of fungi processed biosynthesis, cause bacterium cell death.
The principle of the present invention：In the medical liquid B of the present invention, with coptis ethanol extract, golden cypress ethanol extract and radix scutellariae second
Alcohol extract is raw material, realizes the efficient combination of the compositions such as jamaicin, coptisine, jateorrhizine, worenine, scutelloside,
Collective effect, the growth and breathing of fungi can be suppressed, suppress the oxidizing process of the glycometabolism intermediate product of fungi, particularly suppress
Deoxygenation, so as to kill fungi.And some drug ingedients act on the cell membrane of fungal cell, it is permselective to change its
Property, and then disperse enters cell, is combined with cell nucleic acid film part phospholipid composition, causes organelle to disappear.The decoction of the present invention
B, to the various fungies such as Trichophyton rubrum, alpha fungus, acrothesium floccosum and a small number of filamentous fungis, saccharomycete, pityrosporion ovale
Fungistatic effect it is best.
Further, the decoction A is made up of the raw material of following parts by weight：50 parts of salicylic acid, 200 parts of glacial acetic acid and quality
Percentage is 70% 750 parts of ethanol solution.
Further, the medical liquid B is made up of the raw material of following parts by weight：300 parts of coptis ethanol extract, golden cypress ethanol
100 parts of 100 parts of extract solution and radix scutellariae ethanol extract.
Further, the coptis ethanol extract comprises the following steps：The dry coptis is crushed to particle diameter as 100
Mesh, it is immersed in the ethanol solution that mass concentration is 70%, 24h, after 1500rpm/min centrifuges 10min, Yu Wen is extracted in 50 DEG C
It is that 0.06-0.08MPa is concentrated under reduced pressure to spend for 60-80 DEG C, pressure, then yellow with the ethanol solution that mass concentration is 70%, regulation
Even the concentration of ethanol extract is 1.5g/mL.
Further, the golden cypress ethanol extract comprises the following steps：Dry golden cypress is crushed to particle diameter as 100
Mesh, it is immersed in the ethanol solution that mass concentration is 70%, 24h, after 1500rpm/min centrifuges 10min, Yu Wen is extracted in 50 DEG C
It is that 0.06-0.08MPa is concentrated under reduced pressure to spend for 60-80 DEG C, pressure, then yellow with the ethanol solution that mass concentration is 70%, regulation
The concentration of cypress ethanol extract is 1.5g/mL.
Further, the radix scutellariae ethanol extract comprises the following steps：Dry radix scutellariae is crushed to particle diameter as 100
Mesh, it is immersed in the ethanol solution that mass concentration is 70%, 24h, after 1500rpm/min centrifuges 10min, Yu Wen is extracted in 50 DEG C
It is that 0.06-0.08MPa is concentrated under reduced pressure to spend for 60-80 DEG C, pressure, then yellow with the ethanol solution that mass concentration is 70%, regulation
The concentration of a kind of reed mentioned in ancient books ethanol extract is 1.5g/mL.
The second object of the present invention, it is to provide the preparation method of the external medicinal liquid of above-mentioned treatment onychomycosis.The present invention's controls
The preparation method of the external medicinal liquid for the treatment of onychomycosis is simple, and raw material sources are extensive, wide market, is adapted to large-scale production.
The technical scheme that the present invention solves above-mentioned technical problem is as follows：A kind of preparation side for the external medicinal liquid for treating onychomycosis
Method, comprise the following steps：
Step 1：Take the raw material of following parts by weight：Salicylic acid 40-60 parts, glacial acetic acid 180-220 parts and mass percent
For 70% ethanol solution 700-800 parts, after being well mixed, decoction A is obtained；
Step 2：Prepare coptis ethanol extract：The dry coptis is crushed, is immersed in the ethanol that mass concentration is 70%
In solution, 22-26h is extracted in 45-55 DEG C, after centrifugation, is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, adjusted
The concentration for saving coptis ethanol extract is 1.0-2.0g/mL；
Prepare golden cypress ethanol extract：Dry golden cypress is crushed, is immersed in the ethanol solution that mass concentration is 70%,
22-26h is extracted in 45-55 DEG C, after centrifugation, is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, adjusts golden cypress second
The concentration of alcohol extract is 1.0-2.0g/mL；
Prepare radix scutellariae ethanol extract：Dry radix scutellariae is crushed, is immersed in the ethanol solution that mass concentration is 70%,
22-26h is extracted in 45-55 DEG C, after centrifugation, is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, adjusts radix scutellariae second
The concentration of alcohol extract is 1.0-2.0g/mL；
Step 3：Take the raw material of following parts by weight：Coptis ethanol extract 250-350 parts, golden cypress ethanol extract 80-
120 parts and radix scutellariae ethanol extract 80-120 parts, after being well mixed, obtain medical liquid B；
Step 4：By weight 1:(2-4), the decoction A that step 1 obtains and the medical liquid B that step 3 obtains are taken, produce described control
Treat the external medicinal liquid of onychomycosis.
The application method of the external medicinal liquid of above-mentioned treatment onychomycosis：Only decoction A is used within first 3 days, 3 times a day, every time by 4-6
Drops physic liquor A is instilled in sick first seam, clears up the cuticula and secretion, tamper of disease first and skin.Start within 4th day, only use medicine
Liquid B, 2 times a day, 4-6 drops physic liquors B is instilled in sick first seam every time, thoroughly kills and colonizes in deck and surrounding skin cuticula
Fungi, onychomycosis is obtained wholistic therapy and is effected a radical cure, prevent to recur.Using the present invention treatment onychomycosis external medicinal liquid,
General visible significant results on the 15th, cure rate are up to more than 95%.
Beneficial effects of the present invention：
(1) external medicinal liquid for the treatment of onychomycosis of the invention, can effectively treat onychomycosis, treatment time is short, curative effect is high, nothing
Side effect, easy to use, cost is low, it is thorough eradicate, do not recur.
(2) external medicinal liquid for the treatment of onychomycosis of the invention, directly instilled in disease first stitches, rather than prior art drops in
In sick first, without nail is scraped, permeability is strong, and effect is obvious, significant effect.
(3) preparation method of the invention is simple, and raw material sources are extensive, wide market, is adapted to large-scale production.
Embodiment
The principle and feature of the present invention are described below in conjunction with specific embodiment, example is served only for explaining this hair
It is bright, it is not intended to limit the scope of the present invention.
Embodiment 1：
The external medicinal liquid of the treatment onychomycosis of the present embodiment, by decoction A and medical liquid B by weight 1:2 compositions, wherein, institute
Decoction A is stated to be made up of the raw material of following weight：Salicylic acid 40kg, glacial acetic acid 220kg and mass concentration are 70% ethanol solution
700kg, the medical liquid B are made up of the raw material of following weight：Coptis ethanol extract 250kg, golden cypress ethanol extract 120kg and
Radix scutellariae ethanol extract 80kg, wherein, the coptis ethanol extract comprises the following steps：The dry coptis is crushed to grain
Footpath is 100 mesh, is immersed in the ethanol solution that mass concentration is 70%, and 26h, 1500rpm/min centrifugations 10min are extracted in 45 DEG C
Afterwards, in temperature be 60 DEG C, pressure be that 0.06MPa is concentrated under reduced pressure, then with mass concentration be 70% ethanol solution, adjust the coptis
The concentration of ethanol extract is 1.0g/mL；
The golden cypress ethanol extract comprises the following steps：It is 100 mesh that dry golden cypress is crushed into particle diameter, is immersed in
Mass concentration be 70% ethanol solution in, in 45 DEG C extract 26h, 1500rpm/min centrifugation 10min after, in temperature be 60 DEG C,
Pressure is concentrated under reduced pressure for 0.06MPa, then with the ethanol solution that mass concentration is 70%, the concentration of regulation golden cypress ethanol extract
For 1.0g/mL；
The radix scutellariae ethanol extract comprises the following steps：It is 100 mesh that dry radix scutellariae is crushed into particle diameter, is immersed in
Mass concentration be 70% ethanol solution in, in 45 DEG C extract 26h, 1500rpm/min centrifugation 10min after, in temperature be 60 DEG C,
Pressure is concentrated under reduced pressure for 0.06MPa, then with the ethanol solution that mass concentration is 70%, the concentration of regulation radix scutellariae ethanol extract
For 1.0g/mL.
The preparation method of the external medicinal liquid of above-mentioned treatment onychomycosis, comprises the following steps：
Step 1：Take the raw material of following weight：The ethanol that salicylic acid 40kg, glacial acetic acid 220kg and mass concentration are 70% is molten
Liquid 700kg, after being well mixed, obtain decoction A；
Step 2：Prepare coptis ethanol extract：It is 100 mesh that the dry coptis is crushed into particle diameter, is immersed in mass concentration
For in 70% ethanol solution, extract 26h in 45 DEG C, after 1500rpm/min centrifugations 10min, in temperature be 60 DEG C, pressure be
0.06MPa is concentrated under reduced pressure, and is then with the ethanol solution that mass concentration is 70%, the concentration of regulation coptis ethanol extract
1.0g/mL；
Prepare golden cypress ethanol extract：It is 100 mesh that dry golden cypress is crushed into particle diameter, is immersed in mass concentration as 70%
Ethanol solution in, in 45 DEG C extract 26h, 1500rpm/min centrifugation 10min after, in temperature be 60 DEG C, pressure 0.06MPa
It is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, the concentration of regulation golden cypress ethanol extract is 1.0g/mL；
Prepare radix scutellariae ethanol extract：It is 100 mesh that dry radix scutellariae is crushed into particle diameter, is immersed in mass concentration as 70%
Ethanol solution in, in 45 DEG C extract 26h, 1500rpm/min centrifugation 10min after, in temperature be 60 DEG C, pressure 0.06MPa
It is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, the concentration of regulation radix scutellariae ethanol extract is 1.0g/mL；
Step 3：Take the raw material of following weight kg numbers：Coptis ethanol extract 250kg, golden cypress ethanol extract 120kg and
Radix scutellariae ethanol extract 80kg, after being well mixed, obtain medical liquid B；
Step 4：By weight 1:2, the decoction A that step 1 obtains and the medical liquid B that step 3 obtains are taken, produces the treatment ash
The external medicinal liquid of nail.
Embodiment 2：
The external medicinal liquid of the treatment onychomycosis of the present embodiment, by decoction A and medical liquid B by weight 1:3 compositions, wherein, institute
Decoction A is stated to be made up of the raw material of following weight：Salicylic acid 50kg, glacial acetic acid 200kg and mass concentration are 70% ethanol solution
750kg, the medical liquid B are made up of the raw material of following weight：Coptis ethanol extract 300kg, golden cypress ethanol extract 100kg and
Radix scutellariae ethanol extract 100kg, wherein, the coptis ethanol extract comprises the following steps：The dry coptis is crushed to
Particle diameter is 100 mesh, is immersed in the ethanol solution that mass concentration is 70%, and 24h, 1500rpm/min centrifugations are extracted in 50 DEG C
After 10min, in temperature be 70 DEG C, pressure be that 0.07MPa is concentrated under reduced pressure, then with mass concentration be 70% ethanol solution, adjust
The concentration for saving coptis ethanol extract is 1.5g/mL；
The golden cypress ethanol extract comprises the following steps：It is 100 mesh that dry golden cypress is crushed into particle diameter, is immersed in
Mass concentration be 70% ethanol solution in, in 50 DEG C extract 24h, 1500rpm/min centrifugation 10min after, in temperature be 70 DEG C,
Pressure is concentrated under reduced pressure for 0.07MPa, then with the ethanol solution that mass concentration is 70%, the concentration of regulation golden cypress ethanol extract
For 1.5g/mL；
The radix scutellariae ethanol extract comprises the following steps：It is 100 mesh that dry radix scutellariae is crushed into particle diameter, is immersed in
Mass concentration be 70% ethanol solution in, in 50 DEG C extract 24h, 1500rpm/min centrifugation 10min after, in temperature be 70 DEG C,
Pressure is concentrated under reduced pressure for 0.07MPa, then with the ethanol solution that mass concentration is 70%, the concentration of regulation radix scutellariae ethanol extract
For 1.5g/mL.
The preparation method of the external medicinal liquid of above-mentioned treatment onychomycosis, comprises the following steps：
Step 1：Take the raw material of following weight：The ethanol that salicylic acid 50kg, glacial acetic acid 200kg and mass concentration are 70% is molten
Liquid 750kg, after being well mixed, obtain decoction A；
Step 2：Prepare coptis ethanol extract：It is 100 mesh that the dry coptis is crushed into particle diameter, is immersed in mass concentration
For in 70% ethanol solution, extract 24h in 50 DEG C, after 1500rpm/min centrifugations 10min, in temperature be 70 DEG C, pressure be
0.07MPa is concentrated under reduced pressure, and is then with the ethanol solution that mass concentration is 70%, the concentration of regulation coptis ethanol extract
1.5g/mL；
Prepare golden cypress ethanol extract：It is 100 mesh that dry golden cypress is crushed into particle diameter, is immersed in mass concentration as 70%
Ethanol solution in, in 50 DEG C extract 24h, 1500rpm/min centrifugation 10min after, in temperature be 70 DEG C, pressure 0.07MPa
It is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, the concentration of regulation golden cypress ethanol extract is 1.5g/mL；
Prepare radix scutellariae ethanol extract：It is 100 mesh that dry radix scutellariae is crushed into particle diameter, is immersed in mass concentration as 70%
Ethanol solution in, in 50 DEG C extract 24h, 1500rpm/min centrifugation 10min after, in temperature be 70 DEG C, pressure 0.07MPa
It is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, the concentration of regulation radix scutellariae ethanol extract is 1.5g/mL；
Step 3：Take the raw material of following weight：Coptis ethanol extract 300kg, golden cypress ethanol extract 100kg and radix scutellariae
Ethanol extract 100kg, after being well mixed, obtain medical liquid B；
Step 4：By weight 1:3, the decoction A that step 1 obtains and the medical liquid B that step 3 obtains are taken, produces the treatment ash
The external medicinal liquid of nail.
Embodiment 3：
The external medicinal liquid of the treatment onychomycosis of the present embodiment, by decoction A and medical liquid B by weight 1:4 compositions, wherein, institute
Decoction A is stated to be made up of the raw material of following weight：Salicylic acid 60kg, glacial acetic acid 180kg and mass concentration are 70% ethanol solution
800kg, the medical liquid B are made up of the raw material of following weight：Coptis ethanol extract 350kg, golden cypress ethanol extract 80kg and
Radix scutellariae ethanol extract 120kg, wherein, the coptis ethanol extract comprises the following steps：The dry coptis is crushed to
Particle diameter is 100 mesh, is immersed in the ethanol solution that mass concentration is 70%, and 22h, 1500rpm/min centrifugations are extracted in 55 DEG C
After 10min, in temperature be 80 DEG C, pressure be that 0.06MPa is concentrated under reduced pressure, then with mass concentration be 70% ethanol solution, adjust
The concentration for saving coptis ethanol extract is 2g/mL；
The golden cypress ethanol extract comprises the following steps：It is 100 mesh that dry golden cypress is crushed into particle diameter, is immersed in
Mass concentration be 70% ethanol solution in, in 55 DEG C extract 22h, 1500rpm/min centrifugation 10min after, in temperature be 80 DEG C,
Pressure is concentrated under reduced pressure for 0.06MPa, then with the ethanol solution that mass concentration is 70%, the concentration of regulation golden cypress ethanol extract
For 2g/mL；
The radix scutellariae ethanol extract comprises the following steps：It is 100 mesh that dry radix scutellariae is crushed into particle diameter, is immersed in
Mass concentration be 70% ethanol solution in, in 55 DEG C extract 22h, 1500rpm/min centrifugation 10min after, in temperature be 80 DEG C,
Pressure is concentrated under reduced pressure for 0.06MPa, then with the ethanol solution that mass concentration is 70%, the concentration of regulation radix scutellariae ethanol extract
For 2g/mL.
The preparation method of the external medicinal liquid of above-mentioned treatment onychomycosis, comprises the following steps：
Step 1：Take the raw material of following weight：The ethanol that salicylic acid 50kg, glacial acetic acid 200kg and mass concentration are 70% is molten
Liquid 750kg, after being well mixed, obtain decoction A；
Step 2：Prepare coptis ethanol extract：It is 100 mesh that the dry coptis is crushed into particle diameter, is immersed in mass concentration
For in 70% ethanol solution, extract 22h in 55 DEG C, after 1500rpm/min centrifugations 10min, in temperature be 80 DEG C, pressure be
0.06MPa is concentrated under reduced pressure, and then with the ethanol solution that mass concentration is 70%, the concentration of regulation coptis ethanol extract is 2g/
mL；
Prepare golden cypress ethanol extract：It is 100 mesh that dry golden cypress is crushed into particle diameter, is immersed in mass concentration as 70%
Ethanol solution in, in 55 DEG C extract 22h, 1500rpm/min centrifugation 10min after, in temperature be 80 DEG C, pressure 0.06MPa
It is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, the concentration of regulation coptis ethanol extract is 2g/mL；
Prepare radix scutellariae ethanol extract：It is 100 mesh that dry radix scutellariae is crushed into particle diameter, is immersed in mass concentration as 70%
Ethanol solution in, in 55 DEG C extract 22h, 1500rpm/min centrifugation 10min after, in temperature be 80 DEG C, pressure 0.06MPa
It is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, the concentration of regulation coptis ethanol extract is 2g/mL；
Step 3：Take the raw material of following weight kg numbers：Coptis ethanol extract 350kg, golden cypress ethanol extract 80kg and Huang
A kind of reed mentioned in ancient books ethanol extract 120kg, after being well mixed, obtain medical liquid B；
Step 4：By weight 1:4, the decoction A that step 1 obtains and the medical liquid B that step 3 obtains are taken, produces the treatment ash
The external medicinal liquid of nail.
Clinical effectiveness
(1) patient profile：
The present invention is applied to the clinical treatment that 52 ashes refer to (toe) first out-patient, wherein grey finger nail patient 12, ash
Toenail patient 40, wherein man 35, female 17, age reckling 18 years old is maximum 65 years old, course of disease 2-15, average 8 years.
(2) treatment method：
Clean affected part every time, first three day only uses the decoction A of embodiment 1,2 or 3, three times a day, every time by 4-6 drops physic liquors
A is instilled in sick first seam, clears up the cuticula and secretion, tamper of disease first and skin.Start within 4th day, only using embodiment 1,
2 or 3 medical liquid B, twice daily, 4-6 drops physic liquors B is instilled into sick first every time.15 days as one therapeutic course, the medicine of the present invention is used continuously
Two courses for the treatment of of liquid.
(3) efficacy assessment standard：
Cure：After new nail is grown, nail root reddens, and functional activity recovers normal, fungus microscope examination is feminine gender；
Effectively：Clinical symptoms are clearly better or disappeared substantially, and fungus microscope examination is feminine gender；
It is invalid：Clinical symptom and sign is without improvement.
Efficacy evaluation result is observed disease first outward appearance and is combined the inquiry to patient with estimation mode.
(4) therapeutic effect：
Clinical cure 45, accounts for 86.5%；Effective 6, account for 11.5%；Invalid 1, account for 2%；Total effective rate 98%.Institute
There is case to be not apparent from adverse reaction, 1 invalid to be that diabetes are relevant with the patient.
Case：
(1) king xx, man, 65 years old, people from Guilin, suffers from onychomycosis 8 years, goes many place treatments, and effect is always less
It is good, it is dry and cracked serious after autumn, it is all highly difficult by thing, very big inconvenience is brought to daily life, used many sprays to smear medicine
Product, often repeatedly, it is impossible to eradicate.Afterwards using the decoction of the present invention, affected part, the first 3 days decoctions for only using embodiment 1 are cleaned every time
A, 3 times a day, 4-6 drops physic liquors A is instilled in sick first seam every time.Start within 4th day, only use embodiment 1 medical liquid B, daily 2
It is secondary, 4-6 drops physic liquors B is instilled in sick first seam every time.Cured after adhering to 15 days, and nearly 2 years no relapse.
(2) old xx, man, 35 years old, people from Liuzhou, five right crus of diaphragm halluces first, two big toe, middle toe and left foot toenail illness
8 years, onychomycosis is diagnosed as on inspection, first was pulled out in hospital, has been got well 2 years and has been recurred, used many externally applied drugs, has not all felt any better,
Often repeatedly.The decoction of the present invention is used afterwards, every time clean affected part, the first 3 days decoction A for only using embodiment 2,3 times a day, often
It is secondary to instill 4-6 drops physic liquors A in sick first seam.Start within 4th day, the medical liquid B of embodiment 2 is only used, 2 times a day, every time by 4-6 drops
Medical liquid B is instilled in sick first seam.Cured after adhering to 2 months, and nearly 2 years no relapse.
(3) Xiao XX, man, 56 years old, Yongzhou City people, left foot halluces, two big toes, unknown toe, right crus of diaphragm middle toe, right hand thumb
Finger, forefinger are ill 5 years, are diagnosed as onychomycosis on inspection, have seen many hospitals, ate medicine, and medicine is crossed in also external application very much, when treating one section
Between cure several nails, be discontinued rear and all bad, never thoroughly cured.Afterwards using the decoction of the present invention, clean suffer from every time
Place, the first 3 days decoction A for only using embodiment 3,3 times a day, 4-6 drops physic liquors A is instilled in sick first seam every time.Start within 4th day,
The medical liquid B of embodiment 3 is only used, 2 times a day, is every time instilled 4-6 drops physic liquors B in sick first seam.Cured after adhering to 2 months, and
And nearly 2 years no relapse.
As can be seen here, the external medicinal liquid for the treatment of onychomycosis of the invention, onychomycosis can be effectively treated, treatment time is short, treats
Effect is high, have no side effect, be easy to use, cost is low, thorough eradicate, does not recur.
The foregoing is only presently preferred embodiments of the present invention, be not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent substitution and improvements made etc., it should be included in the scope of the protection.
Claims (7)
1. a kind of external medicinal liquid for treating onychomycosis, it is characterised in that by decoction A and medical liquid B by weight 1:(2-4) is formed,
Wherein, the decoction A is made up of the raw material of following parts by weight：Salicylic acid 40-60 parts, glacial acetic acid 180-220 parts and quality are dense
Ethanol solution 700-800 parts for 70% are spent, the medical liquid B is made up of the raw material of following parts by weight：Coptis ethanol extract
250-350 parts, golden cypress ethanol extract 80-120 parts and radix scutellariae ethanol extract 80-120 parts, wherein, the coptis ethanol carries
Liquid is taken to comprise the following steps：The dry coptis is crushed, is immersed in the ethanol solution that mass concentration is 70%, in 45-55
DEG C extraction 22-26h, after centrifugation, is concentrated under reduced pressure, then with the ethanol solution that mass concentration is 70%, regulation coptis ethanol extraction
The concentration of liquid is 1.0-2.0g/mL；
The golden cypress ethanol extract comprises the following steps：Dry golden cypress is crushed, it is 70% to be immersed in mass concentration
In ethanol solution, 22-26h is extracted in 45-55 DEG C, after centrifugation, is concentrated under reduced pressure, it is then molten with the ethanol that mass concentration is 70%
Liquid, the concentration of regulation golden cypress ethanol extract is 1.0-2.0g/mL；
The radix scutellariae ethanol extract comprises the following steps：Dry radix scutellariae is crushed, it is 70% to be immersed in mass concentration
In ethanol solution, 22-26h is extracted in 45-55 DEG C, after centrifugation, is concentrated under reduced pressure, it is then molten with the ethanol that mass concentration is 70%
Liquid, the concentration of regulation radix scutellariae ethanol extract is 1.0-2.0g/mL.
2. a kind of external medicinal liquid for treating onychomycosis according to claim 1, it is characterised in that the decoction A is by as follows
The raw material of parts by weight is made：50 parts of salicylic acid, 200 parts of glacial acetic acid and mass percent are 70% 750 parts of ethanol solution.
3. a kind of external medicinal liquid for treating onychomycosis according to claim 1, it is characterised in that the medical liquid B is by as follows
The raw material of parts by weight is made：300 parts of coptis ethanol extract, 100 parts of golden cypress ethanol extract and radix scutellariae ethanol extract 100
Part.
A kind of 4. external medicinal liquid for treating onychomycosis according to claim 1 or 3, it is characterised in that the coptis ethanol
Extract solution comprises the following steps：It is 100 mesh that the dry coptis is crushed into particle diameter, is immersed in the ethanol that mass concentration is 70%
In solution, in 50 DEG C extract 24h, 1500rpm/min centrifugation 10min after, in temperature be 60-80 DEG C, pressure 0.06-
0.08MPa is concentrated under reduced pressure, and is then with the ethanol solution that mass concentration is 70%, the concentration of regulation coptis ethanol extract
1.5g/mL。
A kind of 5. external medicinal liquid for treating onychomycosis according to claim 1 or 3, it is characterised in that the golden cypress ethanol
Extract solution comprises the following steps：It is 100 mesh that dry golden cypress is crushed into particle diameter, is immersed in the ethanol that mass concentration is 70%
In solution, in 50 DEG C extract 24h, 1500rpm/min centrifugation 10min after, in temperature be 60-80 DEG C, pressure 0.06-
0.08MPa is concentrated under reduced pressure, and is then with the ethanol solution that mass concentration is 70%, the concentration of regulation golden cypress ethanol extract
1.5g/mL。
A kind of 6. external medicinal liquid for treating onychomycosis according to claim 1 or 3, it is characterised in that the radix scutellariae ethanol
Extract solution comprises the following steps：It is 100 mesh that dry radix scutellariae is crushed into particle diameter, is immersed in the ethanol that mass concentration is 70%
In solution, in 50 DEG C extract 24h, 1500rpm/min centrifugation 10min after, in temperature be 60-80 DEG C, pressure 0.06-
0.08MPa is concentrated under reduced pressure, and is then with the ethanol solution that mass concentration is 70%, the concentration of regulation radix scutellariae ethanol extract
1.5g/mL。
7. a kind of preparation method for the external medicinal liquid for treating onychomycosis, it is characterised in that comprise the following steps：
Step 1：Take the raw material of following parts by weight：Salicylic acid 40-60 parts, glacial acetic acid 180-220 parts and mass percent are
70% ethanol solution 700-800 parts, after being well mixed, obtain decoction A；
Step 2：Prepare coptis ethanol extract：The dry coptis is crushed, is immersed in the ethanol solution that mass concentration is 70%
In, 22-26h is extracted in 45-55 DEG C, after centrifugation, is concentrated under reduced pressure, it is then yellow with the ethanol solution that mass concentration is 70%, regulation
Even the concentration of ethanol extract is 1.0-2.0g/mL；
Prepare golden cypress ethanol extract：Dry golden cypress is crushed, is immersed in the ethanol solution that mass concentration is 70%, in
45-55 DEG C of extraction 22-26h, after centrifugation, is concentrated under reduced pressure, and then with the ethanol solution that mass concentration is 70%, adjusts golden cypress ethanol
The concentration of extract solution is 1.0-2.0g/mL；
Prepare radix scutellariae ethanol extract：Dry radix scutellariae is crushed, is immersed in the ethanol solution that mass concentration is 70%, in
45-55 DEG C of extraction 22-26h, after centrifugation, is concentrated under reduced pressure, and then with the ethanol solution that mass concentration is 70%, adjusts radix scutellariae ethanol
The concentration of extract solution is 1.0-2.0g/mL；
Step 3：Take the raw material of following parts by weight：Coptis ethanol extract 250-350 parts, golden cypress ethanol extract 80-120 parts
With radix scutellariae ethanol extract 80-120 parts, after being well mixed, medical liquid B is obtained；
Step 4：By weight 1:(2-4), the decoction A that step 1 obtains and the medical liquid B that step 3 obtains are taken respectively, produce described control
Treat the external medicinal liquid of onychomycosis.
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| CN2017109707115 | 2017-10-18 | ||
| CN201710970711 | 2017-10-18 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528537A (en) * | 2019-01-16 | 2019-03-29 | 西南大学 | A kind of water-soluble nail product and preparation method thereof prevented and/or treat onychomycosis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554347A (en) * | 2003-12-28 | 2004-12-15 | 游学� | Therapeutic liquid for treating leuconychia |
| CN103536823A (en) * | 2012-07-13 | 2014-01-29 | 葛学义 | External-use Chinese medicine tincture for treating psoriasis |
| CN105125987A (en) * | 2015-09-09 | 2015-12-09 | 桂林盛兴电子科技有限公司 | External ointment for treating onychomycosis and preparation method thereof |
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2017
- 2017-11-09 CN CN201711096318.4A patent/CN107823301A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1554347A (en) * | 2003-12-28 | 2004-12-15 | 游学� | Therapeutic liquid for treating leuconychia |
| CN103536823A (en) * | 2012-07-13 | 2014-01-29 | 葛学义 | External-use Chinese medicine tincture for treating psoriasis |
| CN105125987A (en) * | 2015-09-09 | 2015-12-09 | 桂林盛兴电子科技有限公司 | External ointment for treating onychomycosis and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528537A (en) * | 2019-01-16 | 2019-03-29 | 西南大学 | A kind of water-soluble nail product and preparation method thereof prevented and/or treat onychomycosis |
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