CN1078141A - Stickup film of treatment oral ulcer and preparation method thereof - Google Patents
Stickup film of treatment oral ulcer and preparation method thereof Download PDFInfo
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- CN1078141A CN1078141A CN 93101828 CN93101828A CN1078141A CN 1078141 A CN1078141 A CN 1078141A CN 93101828 CN93101828 CN 93101828 CN 93101828 A CN93101828 A CN 93101828A CN 1078141 A CN1078141 A CN 1078141A
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- oral ulcer
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Abstract
A kind of stickup film for the treatment of oral ulcer is made skin with non-toxic plastic film, and adhesive is done the middle level, and stomatocace medicine is made internal layer; Adhesive is made up of stickum, skeletal substance and plasticised mass; The preparation method of this stickup film is that non-toxic plastic film is carried out hydrophilic treated, adhesive is coated the middle part of non-toxic plastic film after with water dissolution, oven dry, after mixing well, oral ulcer medicated powder water coats the middle part of adhesive layer, become oral ulcer after the oven dry and paste film, this film can be fixed on flexibly for a long time when using that the affected part, oral cavity is unlikely to be moved apart, and the patient does not have any discomfort sensation, no uncomfortable abnormal smells from the patient in the oral cavity.
Description
The present invention relates to stickup film that is used for the treatment of oral ulcer and preparation method thereof.
At present the method for treatment oral ulcer is that medicated powder directly is sprayed at the affected part, oral cavity, dissolves the back drug dispersion in the oral cavity, and not only bitter in the mouth and numbness make the patient that like a hen on a hot girdle sensation be arranged unbearably.The KOUQIANG KUIYANG MO that a kind of Western medicine type is arranged recently, film is affixed on the affected part, oral cavity can treats oral ulcer, but this film is the film of fiber-like that medicine directly soaks completely whole film, film itself is inviscid, make it be attached to the affected part by intraoral liquid, so poor adhesive force, film moves easily, and medicine is diffusion around film, disperse makes the patient be difficult to stand intraoral foreign odor in the oral cavity, and will notice constantly that film can move apart the affected part at any time.
The object of the present invention is to provide a kind of to the treatment oral ulcer and convenient, practical, effectively paste film and preparation method thereof, the patient only needs the stickup film directly is affixed on the affected part, oral cavity, paste film and can flexibly be fixed on the affected part for a long time, the patient can keep normal and speak, no any discomfort sensation, no uncomfortable abnormal smells from the patient alleviates the misery that ulcer causes greatly in the oral cavity, therapeutic effect is splendid, and the patient is easy to accept.
The present invention is achieved in that the skin of making to paste film with non-toxic plastic film, do to paste the middle level of film with adhesive, with the internal layer of stomatocace medicine do stickup film, adhesive wherein is made up of 50～70% weight stickums, 5～35% weight skeletal substances, 10～25% weight plasticised mass; Stickum can be arabia gum or polyvinylpyrrolidone and composition thereof, and skeletal substance can be polyvinyl alcohol, starch, sodium carboxymethyl cellulose, sodium alginate and composition thereof, and plasticised mass can be glycerol or butantriol and composition thereof; Stomatocace medicine wherein is the mixture of 90～100% weight oral ulcer medicated powder and 0～10% weight adhesive; The preparation method of pasting film is non-toxic plastic film to be carried out surface hydrophilic handle, with 1 part of gluing patch of weight of 1～3 part of weight water dissolution and coat middle part through the non-toxic plastic film of hydrophilic treated, oven dry, mix well stomatocace medicine and coat the middle part of adhesive layer with 0.5～3 part of weight water, oven dry.
The present invention treats oral ulcer and pastes non-toxic plastic film on the film such as polyethylene film etc., can stop the on the other hand diffusion of medicine to film, and the discomfort of having avoided medicine spread in the oral cavity bringing to the patient is felt; The ulcer medicated powder that the present invention pastes the film use is Chinese medicine medicated powder or Western medicine medicated powder such as the watermelon crystal etc. that need the treatment oral ulcer of usefulness; The adhesive of pasting on the film not only can make medicine for ulcer closely attached on the film, and makes and paste film and firmly be fixed on the affected part, oral cavity and be difficult for moving apart; The goo mass-energy of forming adhesive makes between adhesive suction back and the oral cavity wall and produces stronger adhesion, skeletal substance can prevent that adhesive from being dissolved rapidly by too much oral cavity juice, plasticised mass can keep pasting the flexibility of film, by stickum, the adhesive that skeletal substance and plasticised mass are formed is most important on the stickup film, it makes pastes film in case with after the oral cavity inwall contacts, just can absorb certain moisture content makes it to have sticky adhesive in inwall affected part, oral cavity, and make the stickup film have flexibility, thereby make the patient be difficult for feeling to have foreign body in the oral cavity, to cause uncomfortable sensation, can also make simultaneously paste film in the oral cavity affected part fixedly the long period and by the dissolving of oral cavity juice down to coming off, if adhesive does not contain plasticised mass, it is crisp and hard then to paste film, easy embrittlement during use, and can collide the affected part and cause pain, if adhesive do not contain skeletal substance, then adhesive can absorb oral cavity juice and dissolving rapidly in the oral cavity, cause film in the affected part the adherent time shorter.
When using stickup film of the present invention, will paste film and directly be affixed on the affected part, oral cavity, the internal layer of pasting film is that the stomatocace medicine layer directly contacts with ulcer spot.Can be made into the stickup film of circle, ellipse, polygon or other shape of all size area according to oral cavity structure and ulcer area.
The present invention's advantage compared with prior art is as follows: the adhesive that (1) the present invention pastes on the film is harmless, does not have foreign odor; Inviscid when (2) pasting the film drying, during use it is attached to the affected part, oral cavity, cling by absorbing moisture content and surface, affected part, it is soft that film itself also becomes, and the patient does not have uncomfortable sensation; (3) paste drug slow in the film to the unidirectional release in affected part, can disperse in the oral cavity, to the affected part long action time, film itself also protects the affected part not to be subjected to touching of tongue simultaneously, in order to avoid cause pain; (4) stick stickup film of the present invention and can keep normal and speak at the oral ulcer place, and film can be fixed more than one hour in the affected part.Stickup film of the present invention uses proof through hospital clinical, and oral ulcer is had obvious curative effects.
Embodiment 1
70% weight arabia gum, 5% weight starch and 25% weight glycerol mix homogeneously are become adhesive, 90% weight oral ulcer medicated powder watermelon crystal and 10% weight adhesive are mixed into stomatocace medicine.When system is pasted film, be that 20 millimeters round polyethylene film surface is coated with the very thin polyvinyl alcohol of one deck at diameter; With 1 part of weight adhesive of 1 part of weight water dissolution and coat middle part through the polyethylene film of hydrophilic treated, this adhesive coating is diameter on the polyethylene film surface be 15 millimeters circular concentric, oven dry; Mix well 1 part of weight stomatocace medicine and coat the middle part of adhesive layer with 0.5 part of weight water, be diameter and be 8 millimeters circular concentric on adhesive layer, oven dry becomes stickup film of the present invention.
Embodiment 2
55% weight polyvinylpyrrolidone, 35% weight polyvinyl, 10% weight butantriol mix homogeneously are become adhesive; When system is pasted film, be that 20 millimeters round polyethylene film surface is coated with the very thin polyvinyl alcohol of one deck at diameter; With 1 part of weight adhesive of 3 parts of weight water dissolutioies and coat middle part, oven dry through the polyethylene film of hydrophilic treated; Mix well 1 part of weight oral ulcer medicated powder watermelon crystal and coat the middle part of adhesive layer with 5 parts of weight water, become stickup film of the present invention after the oven dry.
Embodiment 3
40% weight arabia gum, 30% weight polyvinylpyrrolidone, 15% weight sodium carboxymethyl cellulose, 10% weight glycerol and 5% weight butantriol mix homogeneously are become adhesive, 95% oral ulcer medicated powder watermelon crystal and 5% weight adhesive are mixed into stomatocace medicine; When system is pasted film, be that 20 millimeters round polyethylene film surface is coated with the very thin polyvinyl alcohol of one deck at diameter; With 1 part of weight adhesive of 2 parts of weight water dissolutioies and coat through in the middle of the polyethylene film of hydrophilic treated partly, oven dry; Mix well 1 part of weight stomatocace medicine and coat the middle part of adhesive layer with 1 deal water, become stickup film of the present invention after the oven dry.
Claims (4)
1, a kind of stickup film of the treatment oral ulcer that constitutes by skin, middle level, internal layer, it is characterized in that this stickup film is outer with the non-toxic plastic film work, do the middle level with adhesive, make internal layer with stomatocace medicine, adhesive is made up of 50～70% weight stickums, 5～35% weight skeletal substances, 10～25% weight plasticised mass.
2, according to the stickup film of claim 1, the stickum that it is characterized in that forming adhesive can be arabia gum or polyvinylpyrrolidone and composition thereof, skeletal substance can be polyvinyl alcohol, starch, sodium carboxymethyl cellulose, sodium alginate and composition thereof, and plasticised mass can be glycerol or butantriol and composition thereof.
3, according to the stickup film of claim 1, the stomatocace medicine that it is characterized in that pasting on the film is the mixture of 90～100% weight oral ulcer medicated powder and 0～10% weight adhesive.
4, a kind of preparation method of stickup film of the treatment oral ulcer that constitutes by skin, middle level, internal layer, it is characterized in that non-toxic plastic film is carried out surface hydrophilic to be handled, with 1 part of weight adhesive of 1～3 part of weight water dissolution and coat middle part through the non-toxic plastic film of hydrophilic treated, oven dry, mix well stomatocace medicine and coat the middle part of adhesive layer with 0.5～3 part of weight water, oven dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101828 CN1078141A (en) | 1993-02-20 | 1993-02-20 | Stickup film of treatment oral ulcer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93101828 CN1078141A (en) | 1993-02-20 | 1993-02-20 | Stickup film of treatment oral ulcer and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1078141A true CN1078141A (en) | 1993-11-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93101828 Pending CN1078141A (en) | 1993-02-20 | 1993-02-20 | Stickup film of treatment oral ulcer and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1078141A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142562A (en) * | 2013-03-26 | 2013-06-12 | 钟春燕 | Sustained-release sticking film for treating oral ulcer |
| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN110151998A (en) * | 2019-05-15 | 2019-08-23 | 南京华开生物科技有限公司 | A kind of canker sore repair membrane and preparation method thereof |
| CN113713113A (en) * | 2021-09-28 | 2021-11-30 | 四川大学 | Composition for treating oral mucosa diseases and preparation method thereof |
-
1993
- 1993-02-20 CN CN 93101828 patent/CN1078141A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142562A (en) * | 2013-03-26 | 2013-06-12 | 钟春燕 | Sustained-release sticking film for treating oral ulcer |
| CN103142562B (en) * | 2013-03-26 | 2015-03-25 | 钟春燕 | Sustained-release sticking film for treating oral ulcer |
| CN106109445A (en) * | 2016-06-22 | 2016-11-16 | 佛山市高明绿化纳新材料有限公司 | A kind of long-acting slow-release film for treating oral ulcer and preparation method thereof |
| CN110151998A (en) * | 2019-05-15 | 2019-08-23 | 南京华开生物科技有限公司 | A kind of canker sore repair membrane and preparation method thereof |
| CN113713113A (en) * | 2021-09-28 | 2021-11-30 | 四川大学 | Composition for treating oral mucosa diseases and preparation method thereof |
| CN113713113B (en) * | 2021-09-28 | 2023-09-19 | 四川护家卫士生物医药科技有限公司 | Composition for treating oral mucosa diseases and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |