CN107782920A - The fixing device of atomic force microscope probe functional modification - Google Patents
The fixing device of atomic force microscope probe functional modification Download PDFInfo
- Publication number
- CN107782920A CN107782920A CN201710824400.8A CN201710824400A CN107782920A CN 107782920 A CN107782920 A CN 107782920A CN 201710824400 A CN201710824400 A CN 201710824400A CN 107782920 A CN107782920 A CN 107782920A
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- China
- Prior art keywords
- groove
- probe
- comb
- force microscope
- atomic force
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01Q—SCANNING-PROBE TECHNIQUES OR APPARATUS; APPLICATIONS OF SCANNING-PROBE TECHNIQUES, e.g. SCANNING PROBE MICROSCOPY [SPM]
- G01Q60/00—Particular types of SPM [Scanning Probe Microscopy] or microscopes; Essential components thereof
- G01Q60/24—AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes
- G01Q60/38—Probes, their manufacture, or their related instrumentation, e.g. holders
- G01Q60/42—Functionalisation
Abstract
The present invention provides a kind of fixing device of atomic force microscope probe functional modification, is made up of fluted body mechanism, lid mechanism and screw nut.Fluted body mechanism is that have comb shape groove in upper surface of base plate, and there are probe groove and manhole in comb shape groove lower surface, in addition, the bottom surface of substrate has hexagonal hole.Lid mechanism is made up of cover plate and handle.It is after atomic force microscope probe is placed into probe groove, the comb handle part of the cover plate of cap structure and comb shape groove is closely sealed, then fixed by screw nut, so as to which probe to be fixed to and reserved the space required for probe functional modification.The present invention makes simply, can make atomic force microscope probe functional modification process operation simply, conveniently, and without worrying that probe damages in the process, and required functionization modification liquid is less, meets expensive biomolecule Research Requirements.
Description
Technical field
The present invention relates to the fixed equipment of sample working process, and in particular to a kind of atomic force microscope probe functionalization is repaiied
The fixing device of decorations.
Background technology
AFM has been widely used for analyzing mechanical behavior of the life science molecule in single molecules level.It is such
The experimentation of research is divided into three steps, including atomic force microscope probe and substrate biomolecule functional modification, AFM unimolecules
Test, the analysis of power modal data etc..Wherein atomic force microscope probe functional modification be determine unimolecule test experiments whether into
The prerequisite of work(, scientists are typically directed to develop various probe modification strategies, are such as directed to Au probe or silicon
Probe designs different strategies to modify upper protein molecule, and detecting probe surface modifies different identification macromolecules, and detecting probe surface is repaiied
Adorn DNA etc..Such research has greatly promoted the application that AFM single molecules level is studied.
Because atomic force microscope probe is smaller (such as 1.6mm width, 3.4mm length, 0.3mm thickness), the pin of front end
Sharp (0.45mm length) easily easily encounters wall damage during functional modification because probe is not fixed, current work(
It can change that probe is mainly placed in the internal diameter glass tube more bigger than probe width by modification or hydrophobic clean substrate is enterprising
OK, but probe is added to that technical difficulty in glass tube is higher by the former and easy needle point destroys, the latter is easily in cleaning process
Middle probe overturns and causes needle point to destroy.A kind of support meanss invention of existing AFM functional modification
(US8484758B2), its device design is that the device is placed into liquid bottles after assembling, thus required amount of liquid is larger
(>1mL ranks), it is impossible to meet the needs of expensive biomolecule modification (several 10 μ L to several 100 μ L), and its probe is in the device
With larger removable space, thus probe may mutually be encountered and damage.Show therefore, it is necessary to design a kind of atomic force
The fixing device of micro mirror probe functional modification, probe can be fixed, biomolecule modification liquid only needs several 10 μ L to several 100 μ
L, so that risk that is simple to operate, reducing probe tip damage and meeting the requirement of expensive biomolecule modification.
The content of the invention
For in the prior art the defects of, the present invention provides a kind of easy atomic force microscope probe functional modification
Fixing device.
A kind of fixing device of atomic force microscope probe functional modification, it is characterised in that：Including fluted body mechanism
(1), lid mechanism (2) and screw nut (3).
Further, fluted body mechanism (1) is that have comb shape groove (12), comb shape groove in substrate (11) upper surface
(12) there are probe groove (13) and manhole (14) in lower surface, in addition, the bottom surface of substrate (11) has hexagonal hole (15), its
In：
The comb handle part of comb shape groove (12) is cuboid groove, length 1-20cm, width 1-8cm, and depth is
0.3-1cm, the comb part groove of comb shape groove (12) is cuboid and the semicylinder being connected on cuboid short side, is grown
The size of cube structure is equal to or more than the size of probe groove rectangular parallelepiped structure, length 3.5mm-1cm, and width is
1.6mm-1cm, depth 0.3-1cm, comb part quantity can process as needed, and each comb part has one
Probe groove (13), probe groove (13) are cuboid and the semicylinder that is connected on cuboid short side, be highly equal to or
It is 0.3-0.5mm slightly larger than the height of atomic force microscope probe (4), the length and width of cuboid groove shows than atomic force
The length and width of micro mirror probe (4) is bigger, length 3.5-5mm, width 1.6-2mm, and a cuboid groove part is located at
In the comb handle part of comb shape groove (12), another part is located in the comb part of comb shape groove (12), manhole
(14) and hexagonal hole (15) is coaxial.
Further, lid mechanism (2) is made up of cover plate (21) and handle (23), and cover plate (21) can be with comb shape groove
(12) comb handle part is closely sealed, length 1-20cm, width 1-8cm, depth 0.3-1cm, has on cover plate (21) circular logical
Hole (22), manhole (22) is equal with manhole (14) diameter of fluted body mechanism (1), and cover plate (21) and comb shape are recessed
The closely sealed rear manhole (22) in comb handle part of groove (12) and (14) are coaxial.
Further, screw nut (3) is made up of screw (31) and hex nut (32), and hex nut (32) can be with
It is close to be fitted in the hexagonal hole (15) of fluted body mechanism (1), and fluted body mechanism (1) bottom surface, screw will not be protruded from
(31) manhole (22) and manhole (14) hex nut with being entrenched in hexagonal hole (15) afterwards can be passed through
(32) screw, and fluted body mechanism (1) bottom surface will not be protruded from.
Further, fluted body mechanism (1) and lid mechanism (2) are made by hydrophobic material, and screw nut pair can
To be made by metal or hard material.
The operation principle of patent of the present invention is as follows：
First, hex nut (32) is fitted in the hexagonal hole (15) of fluted body mechanism (1), then, by groove
Type mechanism (1) is placed on the desktop of laboratory, secondly, atomic force microscope probe is sequentially placed into the spy of fluted body mechanism (1)
Pin groove (13) is internal, again, the cover plate (21) of cap structure (2) is put into the comb shape groove (12) of fluted body mechanism (1)
Comb handle part, finally, screw (31) is screwed through manhole (22) and (14) with hex nut (32), passes through 2 pairs
Screw nut tightens fixing device, so as to which probe (4) to be fixed to and reserved the space required for probe functional modification.Dress
Put after assembling, atomic force microscope probe has certain mobile space in probe groove, because probe groove has cuboid
Groove and semicylinder groove composition, in the moving process of probe, two angles of probe can encounter semicylinder wall, still
Probe tip protects probe tip because the presence of semicylinder groove is without encountering wall, is visited so as to avoid
Damage of the pin needle point during functional modification.In addition, after device assembles, the comb shape groove of fluted body mechanism (1)
(12) comb part is the reative cell during functional modification, and reaction kinetic liquid (such as protein solution) is added to this
In reative cell, it is several 10 μ L to several 100 μ L that this reative cell, which can be processed into volume according to demand, so as to meet to modify
Experiment demand when liquid is less.
The present invention solve atomic force microscope probe functional modification process middle probe be easily damaged with required solution compared with
The problem of more, make atomic force microscope probe functional modification process operation simply, conveniently, without worrying that probe damages in the process
It is bad, and required functionization modification liquid is less, meets expensive biomolecule Research Requirements.The present invention makes simply, can be satisfied with
AFM unimolecule tests user's request.
Brief description of the drawings
Accompanying drawing 1 is the dimensional structure diagram of each several part and atomic force microscope probe of the present invention.
Accompanying drawing 2 is the dimensional structure diagram after each several part and atomic force microscope probe of the present invention assemble.
Accompanying drawing 3 is the top view after each several part and atomic force microscope probe of the present invention assemble.
1- fluted bodies mechanism, 11- substrates, 12- comb shapes groove, 13- probes groove, 14- manholes, 15- hexagons
Hole
2- lid mechanisms, 21- cover plates, 22- manholes, 23- handles
3- screw nuts, 31- screws, 32- hex nuts
4- atomic force microscope probes
Embodiment
Embodiments of the invention combination accompanying drawing is elaborated below, premised on the technical solution of the present invention of the present embodiment one
Implemented, but the protection of the present invention is not limited to following embodiments.
Embodiment 1：A kind of fixing device of atomic force microscope probe functional modification, including fluted body mechanism (1), lid
Clamp mechanism (2) and 2 pairs of screw nuts (3).
Fluted body mechanism (1) is that have comb shape groove (12), comb shape groove (12) lower surface in substrate (11) upper surface
There are probe groove (13) and 2 manholes (14), in addition, the bottom surface of substrate (11) has 2 hexagonal holes (15).
The comb handle part of comb shape groove (12) is cuboid groove, length 5cm, width 4cm, depth 0.3cm,
The comb part groove of comb shape groove (12) is cuboid and the semicylinder that is connected on cuboid short side, rectangular parallelepiped structure
Size be equal to or more than the size of probe groove rectangular parallelepiped structure, length 3.5mm, width 1.6mm, depth is
0.3cm, comb part quantity can process as needed, and each comb part has a probe groove (13), probe
Groove (13) is cuboid and the semicylinder being connected on cuboid short side, and height is equal to or slightly greater than AFM
The height of probe (4), is 0.3mm, the length and width of the length and width of cuboid groove than atomic force microscope probe (4)
Bigger, length 3.5mm, width 1.6mm, a cuboid groove part are located in the comb handle part of comb shape groove (12),
Another part is located in the comb part of comb shape groove (12), and manhole (14) and hexagonal hole (15) are coaxial.
Lid mechanism (2) is made up of cover plate (21) and handle (23), and cover plate (21) can be with the comb of comb shape groove (12)
Handle portion is closely sealed, length 5cm, width 4cm, depth 0.3cm, there is 2 manholes (22) on cover plate (21), and circle is led to
Hole (22) is equal with manhole (14) diameter of fluted body mechanism (1), and the comb handle of cover plate (21) and comb shape groove (12)
Manhole (22) and (14) are coaxial after part is closely sealed.
Screw nut (3) is made up of screw (31) and hex nut (32), and hex nut (32) can be closely fitted together to
Into the hexagonal hole (15) of fluted body mechanism (1), and fluted body mechanism (1) bottom surface will not be protruded from, screw (31) can be worn
Manhole (22) and manhole (14) is crossed to screw with the hex nut (32) being entrenched in hexagonal hole (15) afterwards, and not
Fluted body mechanism (1) bottom surface can be protruded from.
Fluted body mechanism (1) and lid mechanism (2) are made by polytetrafluoroethylene (PTFE), and screw nut is to can be by metal system
Form.
Embodiment 2：A kind of fixing device of atomic force microscope probe functional modification, it is characterised in that：Including groove
Type mechanism (1), lid mechanism (2) and 2 pairs of screw nuts (3).
Fluted body mechanism (1) is that have comb shape groove (12), comb shape groove (12) lower surface in substrate (11) upper surface
There are probe groove (13) and 2 manholes (14), in addition, the bottom surface of substrate (11) has 2 hexagonal holes (15).
The comb handle part of comb shape groove (12) is cuboid groove, length 10cm, width 6cm, and depth is
0.5cm, the comb part groove of comb shape groove (12) are cuboid and the semicylinder being connected on cuboid short side, rectangular
The size of body structure is equal to or more than the size of probe groove rectangular parallelepiped structure, length 0.5cm, width 0.4cm, depth
For 0.5cm, comb part quantity can process as needed, and each comb part has a probe groove (13), visit
Pin groove (13) is cuboid and the semicylinder being connected on cuboid short side, and height is equal to or slightly greater than atomic force microscopy
The height of mirror probe (4), is 0.4mm, the length and width of the length and width of cuboid groove than atomic force microscope probe (4)
Bigger, length 4mm, width 1.6mm are spent, a cuboid groove part is located in the comb handle part of comb shape groove (12),
Another part is located in the comb part of comb shape groove (12), and manhole (14) and hexagonal hole (15) are coaxial.
Lid mechanism (2) is made up of cover plate (21) and handle (23), and cover plate (21) can be with the comb of comb shape groove (12)
Handle portion is closely sealed, length 10cm, width 6cm, depth 0.5cm, there is 2 manholes (22) on cover plate (21), circular
Through hole (22) is equal with manhole (14) diameter of fluted body mechanism (1), and the comb of cover plate (21) and comb shape groove (12)
Manhole (22) and (14) are coaxial after handle portion is closely sealed.
Screw nut (3) is made up of screw (31) and hex nut (32), and hex nut (32) can be closely fitted together to
Into the hexagonal hole (15) of fluted body mechanism (1), and fluted body mechanism (1) bottom surface will not be protruded from, screw (31) can be worn
Manhole (22) and manhole (14) is crossed to screw with the hex nut (32) being entrenched in hexagonal hole (15) afterwards, and not
Fluted body mechanism (1) bottom surface can be protruded from.
Fluted body mechanism (1) and lid mechanism (2) are made by polytetrafluoroethylene (PTFE), and screw nut is to can be by hard material
Material is made.
Embodiment 3：A kind of fixing device of atomic force microscope probe functional modification, it is characterised in that：Including groove
Type mechanism (1), lid mechanism (2) and 2 pairs of screw nuts (3).
Fluted body mechanism (1) is that have comb shape groove (12), comb shape groove (12) lower surface in substrate (11) upper surface
There are probe groove (13) and 2 manholes (14), in addition, the bottom surface of substrate (11) has 2 hexagonal holes (15).
The comb handle part of comb shape groove (12) is cuboid groove, length 20cm, width 8cm, depth 1cm,
The comb part groove of comb shape groove (12) is cuboid and the semicylinder that is connected on cuboid short side, rectangular parallelepiped structure
Size be equal to or more than probe groove rectangular parallelepiped structure size, length 1cm, width 1cm, depth 1cm, broach
Partial amt can be processed as needed, and each comb part has a probe groove (13), and probe groove (13) is
Cuboid and the semicylinder being connected on cuboid short side, height are equal to or slightly greater than atomic force microscope probe (4)
Highly, it is 0.5mm, the length and width of cuboid groove is more bigger than the length and width of atomic force microscope probe (4), length
For 5mm, width 2mm, in the comb handle part of comb shape groove (12), another part is located at a cuboid groove part
In the comb part of comb shape groove (12), manhole (14) and hexagonal hole (15) are coaxial.
Lid mechanism (2) is made up of cover plate (21) and handle (23), and cover plate (21) can be with the comb of comb shape groove (12)
Handle portion is closely sealed, length 20cm, width 8cm, depth 1cm, there is 2 manholes (22) on cover plate (21), and circle is led to
Hole (22) is equal with manhole (14) diameter of fluted body mechanism (1), and the comb handle of cover plate (21) and comb shape groove (12)
Manhole (22) and (14) are coaxial after part is closely sealed.
Screw nut (3) is made up of screw (31) and hex nut (32), and hex nut (32) can be closely fitted together to
Into the hexagonal hole (15) of fluted body mechanism (1), and fluted body mechanism (1) bottom surface will not be protruded from, screw (31) can be worn
Manhole (22) and manhole (14) is crossed to screw with the hex nut (32) being entrenched in hexagonal hole (15) afterwards, and not
Fluted body mechanism (1) bottom surface can be protruded from.
Fluted body mechanism (1) and lid mechanism (2) are made by polytetrafluoroethylene (PTFE), and screw nut is to can be by hard material
Material is made.
Although present disclosure is discussed in detail by above preferred embodiment, but it should be appreciated that above-mentioned
Description is not considered as limitation of the present invention.After those skilled in the art have read the above, for the present invention's
A variety of modifications and substitutions all will be apparent.Therefore, protection scope of the present invention should be limited to the appended claims.
Claims (5)
- A kind of 1. fixing device of atomic force microscope probe functional modification, it is characterised in that：Including fluted body mechanism (1), Lid mechanism (2) and screw nut (3).
- 2. the fixing device of atomic force microscope probe functional modification according to claim 1, it is characterised in that described Fluted body mechanism (1) is that comb shape groove (12) is provided with substrate (11) upper surface, and comb shape groove (12) lower surface is set There are probe groove (13) and manhole (14), in addition, the bottom surface of substrate (11) has hexagonal hole (15), wherein：The comb handle part of the comb shape groove (12) is cuboid groove, length 1-20cm, width 1-8cm, and depth is 0.3-1cm, the comb part groove of the comb shape groove (12) is cuboid and the semicolumn being connected on cuboid short side Body, the size of rectangular parallelepiped structure are equal to or more than the size of probe groove rectangular parallelepiped structure, length 3.5mm-1cm, width For 1.6mm-1cm, depth 0.3-1cm, comb part quantity can process as needed, and each comb part has one Individual probe groove (13), the probe groove (13) are cuboid and the semicylinder being connected on cuboid short side, height etc. In or slightly larger than atomic force microscope probe (4) height, be 0.3-0.5mm, the length and width of cuboid groove is than former The length and width of sub- force microscope probe (4) is bigger, length 3.5-5mm, width 1.6-2mm, cuboid groove one Divide in the comb handle part of comb shape groove (12), another part is located in the comb part of comb shape groove (12), institute State manhole (14) and hexagonal hole (15) is coaxial.
- 3. the fixing device of atomic force microscope probe functional modification according to claim 1, it is characterised in that described Lid mechanism (2) is made up of cover plate (21) and handle (23), and the cover plate (21) can be with the comb of the comb shape groove (12) Handle portion is closely sealed, length 1-20cm, width 1-8cm, depth 0.3-1cm, has manhole on the cover plate (21) (22)。
- 4. the fixing device of atomic force microscope probe functional modification according to claim 1, it is characterised in that described Screw nut (3) is made up of screw (31) and hex nut (32), and the hex nut (32) can closely be fitted to institute In the hexagonal hole (15) for stating fluted body mechanism (1), and fluted body mechanism (1) bottom surface will not be protruded from, the screw (31) can To be screwed afterwards with the hex nut (32) being entrenched in hexagonal hole (15) through manhole (22) and manhole (14), And fluted body mechanism (1) bottom surface will not be protruded from.
- 5. the fixing device of atomic force microscope probe functional modification according to claim 1, it is characterised in that described Fluted body mechanism (1) and lid mechanism (2) are made by hydrophobic material, and the screw nut is to can be by metal or hard Material is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710824400.8A CN107782920A (en) | 2017-09-13 | 2017-09-13 | The fixing device of atomic force microscope probe functional modification |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710824400.8A CN107782920A (en) | 2017-09-13 | 2017-09-13 | The fixing device of atomic force microscope probe functional modification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107782920A true CN107782920A (en) | 2018-03-09 |
Family
ID=61437969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710824400.8A Pending CN107782920A (en) | 2017-09-13 | 2017-09-13 | The fixing device of atomic force microscope probe functional modification |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107782920A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110488045A (en) * | 2019-09-11 | 2019-11-22 | 重庆医药高等专科学校 | Anti-falling probe charging appliance |
| CN111077347A (en) * | 2019-12-25 | 2020-04-28 | 北京航空航天大学 | Atomic force microscopy probe clamping device |
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| EP2237050A1 (en) * | 2009-03-31 | 2010-10-06 | Centro de Investigación Cooperativa En Biomateriales ( CIC biomaGUNE) | Apparatus and method for the functionalisation of afm tips |
| EP2237051A1 (en) * | 2009-03-31 | 2010-10-06 | Centro de Investigación Cooperativa En Biomateriales ( CIC biomaGUNE) | Liquid-tight container for storing and transporting AFM probes |
| CN205484182U (en) * | 2016-01-29 | 2016-08-17 | 中国科学院长春应用化学研究所 | Four -channel probe fixing device |
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| JP2004361181A (en) * | 2003-06-03 | 2004-12-24 | Olympus Corp | Cantilever wet processing container, cantilever wet processing unit including the same, and cantilever wet processing method using cantilever wet processing container |
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| CN110488045A (en) * | 2019-09-11 | 2019-11-22 | 重庆医药高等专科学校 | Anti-falling probe charging appliance |
| CN110488045B (en) * | 2019-09-11 | 2021-09-03 | 重庆医药高等专科学校 | Anti-falling probe loading equipment |
| CN111077347A (en) * | 2019-12-25 | 2020-04-28 | 北京航空航天大学 | Atomic force microscopy probe clamping device |
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