CN107773813A - A kind of precharging preparation of the erythropoietin class parenteral solution with safety guard - Google Patents
A kind of precharging preparation of the erythropoietin class parenteral solution with safety guard Download PDFInfo
- Publication number
- CN107773813A CN107773813A CN201610786780.6A CN201610786780A CN107773813A CN 107773813 A CN107773813 A CN 107773813A CN 201610786780 A CN201610786780 A CN 201610786780A CN 107773813 A CN107773813 A CN 107773813A
- Authority
- CN
- China
- Prior art keywords
- inner cylinder
- needle
- needle tubing
- safety device
- outer barrel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical class [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 239000003182 parenteral nutrition solution Substances 0.000 title abstract description 13
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 238000006073 displacement reaction Methods 0.000 claims abstract description 15
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 claims description 9
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 claims description 9
- 102000044890 human EPO Human genes 0.000 claims description 9
- 241001149930 Protura <class> Species 0.000 claims description 4
- 108091006020 Fc-tagged proteins Proteins 0.000 claims description 3
- 230000021235 carbamoylation Effects 0.000 claims description 3
- 108020001507 fusion proteins Proteins 0.000 claims description 3
- 102000037865 fusion proteins Human genes 0.000 claims description 3
- 230000006320 pegylation Effects 0.000 claims description 3
- 102000003951 Erythropoietin Human genes 0.000 claims description 2
- 108090000394 Erythropoietin Proteins 0.000 claims description 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 2
- 229940105423 erythropoietin Drugs 0.000 claims description 2
- 210000003462 vein Anatomy 0.000 claims description 2
- 238000002347 injection Methods 0.000 abstract description 11
- 239000007924 injection Substances 0.000 abstract description 11
- 210000003739 neck Anatomy 0.000 description 5
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- JGSARLDLIJGVTE-UHFFFAOYSA-N 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-UHFFFAOYSA-N 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 239000005030 aluminium foil Substances 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/3257—Semi-automatic sleeve extension, i.e. in which triggering of the sleeve extension requires a deliberate action by the user, e.g. manual release of spring-biased extension means
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention relates to medical instruments field, more particularly to a kind of precharging preparation of the erythropoietin class parenteral solution with safety guard.Present invention firstly provides a kind of precharging type syringe with safety device; including safety device; the safety device includes outer barrel and the first inner cylinder being sheathed in outer barrel; first inner cylinder is movably set in outside needle tubing through elastomeric element; the rear end of the outer barrel is provided with needle tubing flange displacement limiting part; first inner cylinder includes Tip protection part, and the outer wall of the first inner cylinder and the inwall of outer barrel, which are correspondingly provided with, to be prevented the first limit assembly of tube rear end abjection outer barrel in first and stop the second limit assembly that the first inner cylinder front end is moved toward syringe needle direction.When erythropoietin class decoction is pre-charged with the needle tubing of the precharging type syringe, the precharging preparation of the erythropoietin class parenteral solution with safety guard is formed.The present invention can eject after the completion of injection by setting safety device, protect syringe needle not injure medical personnel and patient.
Description
Technical field
The present invention relates to medical instruments field, more particularly to a kind of erythropoietin class parenteral solution with safety guard
Precharging preparation.
Background technology
Erythropoietin class product has two kinds of formulations of parenteral solution and freeze-dried powder on current domestic medical market, uses cillin bottle bag
Dress or pre-filled packaging, the bottled product in XiLin are packed, it is necessary to first open, then aspirated again with syringe, so when in use
Easily cause secondary pollution.The syringe needle of syringe is also easy to produce liquor residue with the dead space of needle tubing junction, and usage amount is inaccurate.
Other conventional needle hypodermic injection area is big, patient pain is felt increase.Equally, powder pin need to be added after liquid redissolves and used,
The problem of same can be produced.
Precharging type syringe is the inner packing using precharging type syringe as product, it be will injection medicine directly it is filling
In pre-filled needle tubing, and injection needle is installed on needle tubing, syringe and decoction packing container are combined into one, it is direct during use
Injection, it is very convenient.Precharging type syringe is as a kind of interior packaging material for directly contacting medicine, with traditional packaging material (cillin bottle or peace
Small jar is packed) compare, it is safer convenient.
But precharging type syringe in the market does not install safety device, the syringe needle of precharging type syringe holds
Medical personnel and patient easily are stabbed, infection risk is higher.
The content of the invention
In view of the above the shortcomings that prior art, the technical problem to be solved in the present invention is that providing a kind of band safety protects
The precharging preparation of the erythropoietin class parenteral solution of protection unit.Safety device can eject after the completion of injection, protect syringe needle not
Injure medical personnel and patient.
In order to achieve the above objects and other related objects, the present invention adopts the following technical scheme that：
Present invention firstly provides a kind of precharging type syringe with safety device, including needle tubing, piston, syringe needle, pin
Head helmet and push rod, needle tubing are the hollow circular cylinder of opening, are fixed with syringe needle on the conehead of needle tubing front end, syringe needle is socketed on syringe needle
Helmet, needle-covering cap is interior to be provided with the seal rubber plug supporting with syringe needle, is provided with a piston in needle tubing, piston is connected with push rod, described
The rear end of needle tubing is provided with needle tubing flange；The precharging type syringe also includes safety device, the safety device bag
Outer barrel and the first inner cylinder being sheathed in outer barrel are included, first inner cylinder is movably set in outside the needle tubing through elastomeric element, institute
The rear end for stating outer barrel is provided with needle tubing flange displacement limiting part, and first inner cylinder includes Tip protection part, the first inner cylinder
The inwall of outer wall and outer barrel, which is correspondingly provided with, to be prevented the first limit assembly of tube rear end abjection outer barrel in first and stops the first inner cylinder
The second limit assembly that front end is moved toward syringe needle direction.
Preferably, first limit assembly includes the first limiting section being located on first inner tank theca, described outer
The inwall of cylinder is provided with inwardly protruded second limiting section.
Preferably, first limiting section is provided with multiple, and along the circumferential direction uniformly arrangement.
Preferably, second limit assembly includes being located at the first clamping of outwardly convex on the outer wall of first inner cylinder
Portion and the second card-tight part positioned at the outer cylinder front end, first card-tight part and the second card-tight part Elastic Contact.
Preferably, second card-tight part is provided with multiple grooves, and multiple grooves are along the circumferential direction distributed.
Preferably, the elastomeric element is spring to precharging type syringe, and the spring is looped around the outer of first inner cylinder
On wall.
Preferably, the second inner cylinder is provided with the outer barrel, second inner cylinder is fixed on the needle tubing flange displacement limitation
On part, neck is provided with second inner cylinder, one end of the elastomeric element is fixed on the neck.
Preferably, the rear end of the outer barrel is provided with fixed mount, and the fixed mount is fixed on the needle tubing flange displacement limitation
On part, the flange is between the fixed mount and the needle tubing flange displacement limiting part.
Preferably, the needle diameter is 0.2~0.5mm, and the needle point of syringe needle is double inclined plane, three inclined-planes or five inclined-planes.
Preferably, the needle tubing volume is 1ml, 2ml, 2.25ml, 2.5ml, 3ml or 5ml.
Preferably, the needle-covering cap outer surface is provided with anti-slip veins.
Preferably, erythropoietin class decoction, the erythropoietin class decoction choosing are pre-charged with the needle tubing of the precharging type syringe
From Recombinant Human Erythropoietin, Recombinant Human Erythropoietin-heterozygosis Fc fusion proteins, Recombinant Human Erythropoietin-Fc fusion proteins, change configuration restructuring
The carbamylation derivative of people's erythropoietin, Pegylation Recombinant Human Erythropoietin or Recombinant Human Erythropoietin, form band safeguard protection
The precharging preparation of the erythropoietin class parenteral solution of device.
As described above, precharging type syringe of the present invention and the erythropoietin class parenteral solution with safety guard is pre-
Formula preparation is filled, is had the advantages that：Medical care is extremely easy to use, without suction, without installing syringe needle, reduces the note of patient
Penetrate cost；
1st, avoid, using the generation aspirated repeatedly after dilution and cause plug to be considered to be worth doing, reducing residual and secondary pollution chance；
2nd, design, can be fully utilized without dead space, noresidue decoction, dosage is more accurate；
3rd, Unit Dose Volume is small, and distending pain sense is lighter during injection；
4th, syringe needle is sharp keen, convenient operation, reduces tingling sensation；
5th, it is disposable, direct injection, pollution risk is reduced, increase the drug safety of patient；
6th, after the completion of injecting, safety device is artificially excited, after inner cylinder ejection, injection needle is entangled completely, can effectively protect
The risk that medical personnel infect from acupuncture.
Brief description of the drawings
Fig. 1 is the structural representation when present invention does not excite.
Fig. 2 is the structural representation after the present invention excites.
Fig. 3 is the planar structure schematic diagram of the second card-tight part.
Component label instructions
10 needle tubings
11 pistons
12 syringe needles
13 needle-covering caps
14 push rods
15 needle tubing flanges
20 safety devices
30 outer barrels
31 needle tubing flange displacement limiting parts
311 through holes
32 second limiting sections
33 fixed mounts
40 first inner cylinders
400 Tip protection parts
41 first limiting sections
42 first card-tight parts
43 second card-tight parts
431 grooves
50 elastomeric elements
60 second inner cylinders
61 necks
Embodiment
Embodiments of the present invention are illustrated by particular specific embodiment below, those skilled in the art can be by this explanation
Content disclosed by book understands other advantages and effect of the present invention easily.
It should be clear that structure, ratio, size depicted in this specification institute accompanying drawings etc., only coordinating specification to be taken off
The content shown, so that those skilled in the art understands and reads, the enforceable qualifications of the present invention are not limited to, therefore
Do not have technical essential meaning, the modification of any structure, the change of proportionate relationship or the adjustment of size, do not influenceing the present invention
Under the effect of can be generated and the purpose that can reach, it all should still fall the scope that can cover in disclosed technology contents
It is interior.Meanwhile cited such as " on ", " under ", "left", "right", the term of " centre " in this specification, it is merely convenient to describe
Understand, and be not used to limit the enforceable scope of the present invention, its relativeness is altered or modified, and technology is being changed without essence
Inside hold, when being also considered as the enforceable category of the present invention.
As depicted in figs. 1 and 2, a kind of precharging type syringe with safety device of present invention offer, including needle tubing 10,
Piston 11, syringe needle 12, needle-covering cap 13 and push rod 14, needle tubing 10 is the hollow circular cylinder of opening, on the conehead of the front end of needle tubing 10
Syringe needle 12 is fixed with, is removably socketed needle-covering cap 13 on syringe needle 12, is provided with needle-covering cap 13 and supporting close of syringe needle 12
Sealing plug, be provided with capping of the piston 11 as needle tubing herb liquid in needle tubing, can slide and seal in needle tubing, piston 11 with
Push rod 14 connects, and push rod 14 has one section to be inserted into needle tubing, can be moved with piston 11 in needle tubing, the rear end of the needle tubing 10
Provided with needle tubing flange 15.
As shown in Figure 1 to Figure 3, the precharging type syringe also includes safety device 20, the safety device
Including outer barrel 30 and the first inner cylinder 40 being sheathed in outer barrel 30, first inner cylinder 40 is movably set in institute through elastomeric element 50
State outside needle tubing 10, the rear end of the outer barrel 30 is provided with needle tubing flange displacement limiting part 31, the needle tubing flange displacement limiting unit
Part 31 is provided with through hole 311, and the needle tubing flange displacement limiting part 31 can be used for stopping the needle tubing flange 15, prevent described
Needle tubing flange 15 enters in the outer barrel 30.First inner cylinder 40 includes Tip protection part 400, the bullet of the first inner cylinder 40
When going out, the Tip protection part 400 is enclosed on the periphery of the syringe needle 12, the outer wall of the first inner cylinder 40 and the inwall pair of outer barrel 30
Should be provided with prevents the first limit assembly of tube rear end abjection outer barrel in first and stops that the front end of the first inner cylinder 40 is transported toward syringe needle direction
The second dynamic limit assembly, first limit assembly ensure that when first inner cylinder 40 ejects the outer barrel 30 will not be left.
When not exciting, the rear end of first inner cylinder 40 contacts through the through hole 311 with the needle tubing flange 15, front end with it is described outer
The first inner cylinder 40 is stated in 30 Elastic Contacts of cylinder, the front end of the outer barrel 30 by elastic card residence, and second limit assembly ensures
In the case of no applied external force, first inner cylinder 40 will not move forward.The elastomeric element 50 is positioned at described the
Between one inner cylinder 40 and the outer barrel 30, the elastomeric element 50 applies elastic force to the first limiting section 41, so that described first
Inner cylinder 40 by active force forward, but due to the active force be less than outer barrel 30 front end by fettering first inner cylinder 40
Active force, first inner cylinder 40 is not moved forward in the presence of no external thrust.
Preferably, first limit assembly includes the first limiting section 41 being located on the outer wall of the first inner cylinder 40, institute
The inwall for stating outer barrel 30 is provided with inwardly protruded second limiting section 32.Preferably, first limiting section 41 is provided with multiple, and
Along the circumferential direction uniformly arrangement.After when the present invention excites, first limiting section 41 is moved to the front end of the outer barrel 30, this
Shi Houduan the second limiting section 32 can block first limiting section 41, be moved after preventing first inner cylinder 40, further really
Protect the security used.Preferably, the elastomeric element 50 is spring, and the spring is looped around the outer wall of first inner cylinder 40
On.Preferably, the second inner cylinder 60 is provided with the outer barrel 30, second inner cylinder 60 is fixed on the needle tubing flange displacement limitation
On part 31, neck 61 is provided with second inner cylinder 60, one end of the elastomeric element 60 is fixed on the neck 61.
As shown in Figure 1 to Figure 3, it is preferable that second limit assembly includes being located on the outer wall of first inner cylinder 40
First card-tight part 42 of outwardly convex and the second card-tight part 43 positioned at the front end of outer barrel 30, first card-tight part 42
With the Elastic Contact of the second card-tight part 43.The second card-tight part 43 states the first card by elastic card residence described in precharging type syringe
Tight portion 42, it is ensured that the first inner cylinder 40 will not eject described in when not exciting, and when exciting the present invention, experimenter firmly pushes away forward institute
Push rod 14 is stated, the needle tubing flange 15 promotes forward first inner cylinder 40 to move forward, and first card-tight part 42 is detached institute
The elastic force constraint of the second card-tight part 43 is stated, first inner cylinder 40 is ejected forward due to the elastic force effect of the elastomeric element 50.
Preferably, second card-tight part 43 is provided with multiple grooves 431, and multiple grooves 431 are along the circumferential direction distributed, it is ensured that institute
Stating the first inner cylinder 40 can smoothly eject.
Preferably, the rear end of the outer barrel 30 is provided with fixed mount 33, and the fixed mount 33 is fixed on the needle tubing flange position
Move on limiting part 31, the needle tubing flange 15 be located at the fixed mount 33 and the needle tubing flange displacement limiting part 31 it
Between.Preferably, 12 a diameter of 0.2~0.5mm of syringe needle, the needle point of syringe needle using it is most thin, most sharp for double inclined plane, it is three oblique
Face or five inclined-planes, patient only has slight sensation during injection.Preferably, needle tubing uses borosilicate glass material, and piston uses
Butyl material, the selection of the material can reduce the absorption of decoction.Preferably, the volume of needle tubing 10 be 1ml, 2ml,
2.25ml, 2.5ml, 3ml or 5ml, according to medical treatment and the market demand, new specification can also be increased.Due to facing for various decoctions
The bed amount of recommending is different, also caused by patient's individual difference in itself usage amount difference, erythropoietin class medicine of the invention
The specification of the precharging type syringe of thing can be diversified.
The precharging type syringe of the present invention passes through sterilization treatment, different under the conditions of local laminar flow after detection
The precharging type syringe distinguishes filling Recombinant Human Erythropoietin parenteral solution, Recombinant Human Erythropoietin-heterozygosis Fc fusion proteins, recombined human
Erythropoietin-Fc fusion proteins, change configuration Recombinant Human Erythropoietin, and Pegylation Recombinant Human Erythropoietin parenteral solution and recombined human promote
In the cavity that the carbamylation derivative injection of red pigment surrounds to needle tubing, conehead and piston, every kind of decoction difference is filling
1000IU, 2000IU, 3000IU, 4000IU, 5000IU, 6000IU, 10000IU, 20000IU, 40000IU, 0.1mg,
0.2mg, 0.3mg, 0.4mg, 0.5mg, 0.6mg, 1.0mg, 1.5mg, it is whole to load in safety device after the completion of filling, then use
Aluminium foil or bubble-cap type encapsulation, form the precharging preparation of the erythropoietin class parenteral solution with safety guard.Band safeguard protection fills
The filling of precharging preparation for the erythropoietin class parenteral solution put, lamp inspection, labeling, stubborn bar, loading safety device, plastic packaging use certainly
Dynamic production line is completed.
Through trial-production, precharging type syringe of this kind with safety guard and the erythropoietin class note with safety guard
The precharging preparation of liquid is penetrated, it is easy to use, the risk of clinical infection can be effectively reduced, there is good potential applicability in clinical practice.
In summary, the present invention effectively overcomes various shortcoming of the prior art and has high industrial utilization.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (10)
1. a kind of precharging type syringe with safety device, including needle tubing (10), piston (11), syringe needle (12), syringe needle shield
Cap (13) and push rod (14), needle tubing (10) are the hollow circular cylinder of opening, and syringe needle is fixed with the conehead of needle tubing (10) front end
(12) needle-covering cap (13), is socketed on syringe needle (12), the seal rubber plug supporting with syringe needle (12), pin are provided with needle-covering cap (13)
A piston (11) is provided with pipe (10), piston (11) is connected with push rod (14), it is characterised in that the rear end of the needle tubing (10) is set
There is needle tubing flange (15)；The precharging type syringe also includes safety device (20), and the safety device includes outer
Cylinder (30) and the first inner cylinder (40) being sheathed in outer barrel (30), first inner cylinder (40) are slidingly connected through elastomeric element (50)
In the needle tubing (10) outside, the rear end of the outer barrel (30) is provided with needle tubing flange displacement limiting part (31), first inner cylinder
Including Tip protection part (400), the outer wall of the first inner cylinder (40) and the inwall of outer barrel (30), which are correspondingly provided with, prevents the first inner cylinder
The second limit assembly that first limit assembly of rear end abjection outer barrel and stop the first inner cylinder (40) front end are moved toward syringe needle direction.
2. the precharging type syringe according to claim 1 with safety device, it is characterised in that：Described first is spacing
Component includes being located at the first limiting section (41) on the first inner cylinder (40) outer wall, the inwall of the outer barrel (30) be provided with to
The second limiting section (32) of internal projection.
3. the precharging type syringe according to claim 2 with safety device, it is characterised in that：Described first is spacing
Portion (41) be provided with it is multiple, and along the circumferential direction uniformly arrangement.
4. the precharging type syringe according to claim 1 with safety device, it is characterised in that：Described second is spacing
Component includes being located on the outer wall of first inner cylinder (40) the first card-tight part (42) of outwardly convex and positioned at the outer barrel
(30) the second card-tight part (43) of front end, first card-tight part (42) and the second card-tight part (43) Elastic Contact.
5. the precharging type syringe according to claim 4 with safety device, it is characterised in that：Second clamping
Portion (43) is provided with multiple grooves (431), and multiple grooves (431) are along the circumferential direction distributed.
6. the precharging type syringe according to claim 1 with safety device, it is characterised in that：The elastomeric element
(50) it is spring, the spring is looped around on the outer wall of first inner cylinder (40).
7. the precharging type syringe according to claim 1 with safety device, it is characterised in that：The outer barrel (30)
The second inner cylinder (60) is inside provided with, second inner cylinder (60) is fixed on the needle tubing flange displacement limiting part (31), described
Neck (61) is provided with second inner cylinder (60), one end of the elastomeric element (60) is fixed on the neck (61).
8. the precharging type syringe according to claim 1 with safety device, it is characterised in that：The outer barrel (30)
Rear end be provided with fixed mount (33), the fixed mount (33) is fixed on the needle tubing flange displacement limiting part (31), described
Needle tubing flange (15) is located between the fixed mount (33) and the needle tubing flange displacement limiting part (31).
9. the precharging type syringe according to claim 1 with safety device, it is characterised in that：Also include following special
Any one of sign is multinomial：1) a diameter of 0.2~0.5mm of the syringe needle (12), the needle point of syringe needle is double inclined plane, three inclined-planes or five
Inclined-plane；2) needle tubing (10) volume is 1ml, 2ml, 2.25ml, 2.5ml, 3ml or 5ml；3) needle-covering cap (13) appearance
Face is provided with anti-slip veins.
10. the precharging type syringe according to claim 1 with safety device, it is characterised in that：It is described pre-filled
Erythropoietin class decoction is pre-charged with the needle tubing (10) of syringe, the erythropoietin class decoction is selected from Recombinant Human Erythropoietin, recombined human
Erythropoietin-heterozygosis Fc fusion proteins, Recombinant Human Erythropoietin-Fc fusion proteins, changes configuration Recombinant Human Erythropoietin, Pegylation weight
The carbamylation derivative of group people's erythropoietin or Recombinant Human Erythropoietin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610786780.6A CN107773813A (en) | 2016-08-31 | 2016-08-31 | A kind of precharging preparation of the erythropoietin class parenteral solution with safety guard |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610786780.6A CN107773813A (en) | 2016-08-31 | 2016-08-31 | A kind of precharging preparation of the erythropoietin class parenteral solution with safety guard |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107773813A true CN107773813A (en) | 2018-03-09 |
Family
ID=61451409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610786780.6A Pending CN107773813A (en) | 2016-08-31 | 2016-08-31 | A kind of precharging preparation of the erythropoietin class parenteral solution with safety guard |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107773813A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN109364334A (en) * | 2018-09-28 | 2019-02-22 | 黄桂庭 | A kind of syringe |
| CN111888581A (en) * | 2020-09-10 | 2020-11-06 | 苏州赛卫生物科技有限公司 | Safety syringe with needle protector |
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