CN107753929A - 一种含麦胚球蛋白的保健口服液及其制备方法 - Google Patents
一种含麦胚球蛋白的保健口服液及其制备方法 Download PDFInfo
- Publication number
- CN107753929A CN107753929A CN201711106666.5A CN201711106666A CN107753929A CN 107753929 A CN107753929 A CN 107753929A CN 201711106666 A CN201711106666 A CN 201711106666A CN 107753929 A CN107753929 A CN 107753929A
- Authority
- CN
- China
- Prior art keywords
- parts
- wheat germ
- root
- globulin
- oral liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000209140 Triticum Species 0.000 title claims abstract description 74
- 235000021307 Triticum Nutrition 0.000 title claims abstract description 74
- 108010044091 Globulins Proteins 0.000 title claims abstract description 56
- 102000006395 Globulins Human genes 0.000 title claims abstract description 56
- 239000007788 liquid Substances 0.000 title claims abstract description 45
- 230000036541 health Effects 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims description 11
- 238000000855 fermentation Methods 0.000 claims abstract description 42
- 230000004151 fermentation Effects 0.000 claims abstract description 42
- 150000004676 glycans Chemical class 0.000 claims abstract description 39
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 39
- 239000005017 polysaccharide Substances 0.000 claims abstract description 39
- 241000427159 Achyranthes Species 0.000 claims abstract description 21
- 240000005528 Arctium lappa Species 0.000 claims abstract description 21
- 235000003130 Arctium lappa Nutrition 0.000 claims abstract description 21
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims abstract description 21
- 241001660870 Cyrtomium Species 0.000 claims abstract description 21
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 21
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 21
- 235000013717 Houttuynia Nutrition 0.000 claims abstract description 21
- 240000000691 Houttuynia cordata Species 0.000 claims abstract description 21
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 21
- 240000001659 Oldenlandia diffusa Species 0.000 claims abstract description 21
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 21
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 21
- 244000153955 Reynoutria sachalinensis Species 0.000 claims abstract description 21
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 claims abstract description 21
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 21
- 229940109850 royal jelly Drugs 0.000 claims abstract description 21
- 240000004507 Abelmoschus esculentus Species 0.000 claims abstract description 19
- 235000003934 Abelmoschus esculentus Nutrition 0.000 claims abstract description 19
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 19
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 19
- 244000179560 Prunella vulgaris Species 0.000 claims abstract description 17
- 235000008113 selfheal Nutrition 0.000 claims abstract description 17
- 239000000203 mixture Substances 0.000 claims abstract description 16
- 241000411851 herbal medicine Species 0.000 claims abstract description 15
- 229920001491 Lentinan Polymers 0.000 claims abstract description 13
- 229940115286 lentinan Drugs 0.000 claims abstract description 13
- 241000245665 Taraxacum Species 0.000 claims description 19
- 241000218691 Cupressaceae Species 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000008247 solid mixture Substances 0.000 claims description 15
- 240000006439 Aspergillus oryzae Species 0.000 claims description 10
- 235000002247 Aspergillus oryzae Nutrition 0.000 claims description 10
- 241000235395 Mucor Species 0.000 claims description 10
- 238000005119 centrifugation Methods 0.000 claims description 10
- 239000011265 semifinished product Substances 0.000 claims description 10
- 235000003599 food sweetener Nutrition 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 239000003765 sweetening agent Substances 0.000 claims description 7
- 241000228347 Monascus <ascomycete fungus> Species 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 241000220317 Rosa Species 0.000 claims description 5
- 238000010564 aerobic fermentation Methods 0.000 claims description 5
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 239000002054 inoculum Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- 239000004376 Sucralose Substances 0.000 claims description 2
- 235000021433 fructose syrup Nutrition 0.000 claims description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 2
- 235000019408 sucralose Nutrition 0.000 claims description 2
- 238000011081 inoculation Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 15
- 230000036039 immunity Effects 0.000 abstract description 10
- 230000000259 anti-tumor effect Effects 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 6
- 241000721047 Danaus plexippus Species 0.000 abstract description 3
- 230000003993 interaction Effects 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 230000002478 diastatic effect Effects 0.000 abstract description 2
- 238000003809 water extraction Methods 0.000 abstract description 2
- 240000001949 Taraxacum officinale Species 0.000 abstract 2
- 244000301850 Cupressus sempervirens Species 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 description 11
- 108090000623 proteins and genes Proteins 0.000 description 11
- 239000003814 drug Substances 0.000 description 5
- 230000036737 immune function Effects 0.000 description 5
- 230000000840 anti-viral effect Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 244000025254 Cannabis sativa Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000005760 tumorsuppression Effects 0.000 description 3
- 208000027219 Deficiency disease Diseases 0.000 description 2
- 241000206602 Eukaryota Species 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 102000014150 Interferons Human genes 0.000 description 2
- 108010050904 Interferons Proteins 0.000 description 2
- 201000005505 Measles Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000001109 blastomere Anatomy 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 235000021323 fish oil Nutrition 0.000 description 2
- 108010074605 gamma-Globulins Proteins 0.000 description 2
- 150000002337 glycosamines Chemical class 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 229940079322 interferon Drugs 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000006916 protein interaction Effects 0.000 description 2
- 210000003705 ribosome Anatomy 0.000 description 2
- 210000001324 spliceosome Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 101710102211 11S globulin Proteins 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 101710190853 Cruciferin Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000011200 Kawasaki disease Diseases 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 241001627955 Tetraodon lineatus Species 0.000 description 1
- 241001441726 Tetraodontiformes Species 0.000 description 1
- 241000271897 Viperidae Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008436 biogenesis Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000001531 bladder carcinoma Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000006860 carbon metabolism Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001142 circular dichroism spectrum Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 208000010749 gastric carcinoma Diseases 0.000 description 1
- 239000006049 herbal material Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 229940027941 immunoglobulin g Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 230000004879 molecular function Effects 0.000 description 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000003068 pathway analysis Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000004952 protein activity Effects 0.000 description 1
- 230000020978 protein processing Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 239000012744 reinforcing agent Substances 0.000 description 1
- 230000028706 ribosome biogenesis Effects 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
- A23L2/382—Other non-alcoholic beverages fermented
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Insects & Arthropods (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Animal Husbandry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种含麦胚球蛋白的保健口服液，由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、夏枯草、穿心莲、黄芩、蒲公英、贯众、虎杖、牛膝、甘草和小球藻组成，通过麦胚芽蛋白、白花蛇舌草、灵芝、蜂王浆、牛蒡子、鱼腥草、葛根、川芎、黄柏、穿心莲、蒲公英、枸杞、贯众、虎杖、牛膝、甘草、小球藻等中草药彼此间存在复杂的相互作用关系，君臣佐使合理配比，配以功能多糖，采用“快速固态糖化发酵+高温炒制+二次固态螯合发酵+中温水提”的工艺，多菌协同，充分糅合麦胚球蛋白和中草药中的抗肿瘤提高免疫力的功能活性成分，取得了较好的技术效果。
Description
技术领域
本发明涉及一种口服液，尤其是涉及一种含麦胚球蛋白的保健口服液及其制备方法，属于保健领域。
背景技术
人血丙种球蛋白，主要用于预防麻疹或减轻症状。用于传染性肝炎、麻疹、水痘、腮腺炎、带状疱疹等病毒性感染的防治。用于哮喘、过敏性鼻炎、湿疹等内源性过敏性疾病。用于提高机体的免疫功能：原发性免疫球蛋白缺乏症，常见变异性免疫缺陷病，免疫球蛋白G亚型缺陷病等。继发性免疫球蛋白缺陷病，如重症感染，新生儿败血症等。自身免疫性疾病，如原发性血小板减少性紫癜，川崎病。麦胚球蛋白与人血丙种球蛋白功能类似，是从小麦中提取出来的一类植物源球蛋白。
麦胚球蛋白在麦胚总蛋白中占比20%左右，是麦胚中除白蛋白外含量最高、功能最全的蛋白质。Danielson采用超速离心技术分离并研究了小麦籽粒和谷物胚芽中的球蛋白组分，结果证明麦胚球蛋白是一种相对分子量为213kD的单一蛋白；Burgess等研究证明麦胚球蛋白主要是一种8S球蛋白，包括两个非二硫键连接的亚基，其相对分子量分别为50和40kD；周显青在对麦胚球蛋白的提取研究中，通过SDS-PAGE电泳分析由α、γ、δ三种球蛋白组成；朱科学等对比于前人的研究，发现麦胚球蛋白主要包含单一的γ型8S球蛋白，并通过CD光谱分析二级结构组成及含量，显示其中包含54.9%的β-折叠结构、25.3%的无规卷曲结构和19.8%α-螺旋，未有β-转角结构；同时还发现麦胚球蛋白中还可能含有类似于“Triticins”蛋白的11S球蛋白；其相对分子质量范围为12~60kD。
基于LC/MS对麦胚球蛋白组分鉴定、代谢通路分析，经GO功能注释和KEGG Pathway分析发现麦胚球蛋白共涉及分子功能31种、细胞组成47种和生物过程调控87种，参与到代谢通路调控104条。蛋白质互作网络（PPI）分析，共包含具有统计学特征的蛋白质互作子网络5个，枢纽蛋白23个。对鉴定所得的蛋白质进行KEGG Pathway分析，发现麦胚球蛋白参与到了104条通路，其中***性红斑狼疮（Systemic lupus erythematosus）相关蛋白12%，酒精中毒（Alcoholism）相关蛋白12%，核糖体（Ribosome）相关蛋白10% ，剪接体（Spliceosome）相关蛋白7%，RNA转运（RNA transport）相关蛋白4%，蛋白质在内质网形成过程蛋白（Protein processing in endoplasmic reticulum）4%，碳代谢（Carbonmetabolism）4%，在真核生物核糖体生物起源（Ribosome biogenesis in eukaryotes）4%，氨基糖和核苷酸糖代谢（Amino sugar and nucleotide sugar metabolism）4%等。
白花蛇舌草，其成药味苦、淡，性寒。具有清热解毒、消痛散结、利尿除湿功效。尤善治疗各种类型炎症。在临床实践中，发现白花蛇舌草若与球蛋白配伍得当，具有抑瘤、抗癌功能。竹茹多糖、香菇多糖、秋葵多糖为天然的功能多糖，是一种宿主免疫增强剂(hostdefense potentiator，HDP)，临床与药理研究表明，其具有抗病毒、抗肿瘤、调节免疫功能和刺激干扰素形成等作用；三者结合具有缓解不能手术或复发性胃癌、肝癌、膀胱癌症状，提高病人免疫功能，纠正微量元素失调功能；另外功能糖组合与麦胚球蛋白配合使用，能够保护蛋白活性，增强麦胚球蛋白功效。灵芝、蜂王浆具有提高免疫力、增强细胞活性之功效；牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、小球藻联用具有提高免疫力、抑制肿瘤细胞的功效；夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草具有清热解毒、抗病毒之功效，与上述中草药搭配合理，具有增强药效的作用。
麦胚球蛋白具有抑瘤、增强免疫力的功能，目前常用于食品、保健品、医药等，具有较好的应用开发价值。本发明利用麦胚球蛋白的抑瘤、增强免疫力功能特性和中草药抑制肿瘤、提高免疫的特性相配比，提供一种一种含麦胚球蛋白的保健口服液及其制备方法。
发明内容
本发明的目的是提供一种含麦胚球蛋白的保健口服液及其制备方法，可以提高人们的免疫功能，增强体质，保障人们的健康。
本发明提供一种含麦胚球蛋白的保健口服液，由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻组成。
作为本发明的一种优选技术方案，每1000份口服液中中药原料及质量配比为：麦胚球蛋白3～12份、白花蛇舌草15～30份、竹茹多糖10～15份、香菇多糖10～15份、秋葵多糖10～15份、脱脂麦胚30～50份、灵芝4～8份、蜂王浆2～6份、牛蒡子10～15份、柴胡10～15份、鱼腥草8～12份、葛根10～15份、川芎15～20份、黄柏10～13份、夏枯草10～13份、穿心莲8～12份、黄芩8～12份、蒲公英10～15份、枸杞10～16份、贯众10～18份、虎杖5～10份、牛膝5～10份、甘草10～15份、小球藻10～15份称重；
作为本发明的一种优选技术方案，其中药原料及质量配比为：麦胚球蛋白7份、白花蛇舌草23份、竹茹多糖13份、香菇多糖13份、秋葵多糖13份、脱脂麦胚40份、灵芝6份、蜂王浆4份、牛蒡子13份、柴胡13份、鱼腥草10份、葛根12份、川芎16份、黄柏12份、夏枯草12份、穿心莲10份、黄芩10份、蒲公英13份、枸杞15份、贯众15份、虎杖7份、牛膝7份、甘草12份、小球藻13份。
本发明提供一种含麦胚球蛋白的保健口服液的制备方法，通过以下步骤制备：
（1）分拣称量：将所用中草药分拣，去除杂质等，按照上述比例称重；
（2）原料预处理：将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻混合后进行粉碎处理，过30目筛；
（3）向粉碎后的混合物中加入0.3倍灭菌纯净水，接种米曲霉孢子粉和毛霉孢子粉，平摊在发酵浅盘中，厚度0.6 cm。发酵温度32 ℃，好氧发酵时间12 h后，立即50℃烘干至水分在8%左右，并进行炒制后，自然冷却至室温，得前发酵固体混合物；所述米曲霉接种为0.01%，含孢子120亿/克，毛霉接种量为0.01%，含孢子120亿/克；所述炒制温度200℃，时间30min，翻动频率在120次/分钟；
（4）将前发酵固体混合物，加0.3倍灭菌纯净水，接种0.01%红曲霉干粉，平摊在发酵浅盘中，厚度0.6cm。发酵温度37℃，发酵时间144 h，颜色为玫红色后,立即50℃烘干至水分在8%左右，得后发酵固体混合物；
（5）添加辅料：加入蜂王浆和质量分数为1～2%的甜味剂，加水搅拌定容，加热至70℃，30min；
（6）静置：将口服液半成品常温下静置48h以上；
（7）离心：将口服液半成品5000r/min离心20 min；加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖；
（8）定容分装：将离心后的口服液定容、分装即得口服液成品。
作为本发明的一种优选技术方案，上述甜味剂的组成为三氯蔗糖1份；果糖2.5份；高果糖浆1.5份。
本发明的有益效果是：本发明提供一种含麦胚球蛋白的保健口服液及其制备方法，一是在传统中医理论和实践指导下精选药方，科学配伍麦胚球蛋白和多种中草药，药物组分经辨证配伍，在作用上相互佐助，能显著抗肿瘤提高免疫力；二是在口服液的制备过程中采用“快速固态糖化发酵+高温炒制+二次固态螯合发酵+中温水提”的工艺，多菌协同，充分糅合麦胚球蛋白和中草药中的抗肿瘤提高免疫力的功能活性成分，提高保健效果；三是来源植物天然成分，口服液安全无副作用，饮用方便。
本发明提供一种含麦胚球蛋白的保健口服液及其制备方法，不同的中草药性味各异，功效存在着巨大的差异，不同的中草药组合后存在复杂的相互作用关系，且中草药之间的配比比较密切，不同配比也将使君臣佐使关系发生实质性的变化，从而使复合中草药的关系发生实质性改变。白花蛇舌草具有清热解毒、消痛散结、利尿除湿功效。竹茹多糖、香菇多糖、秋葵多糖具有抗病毒、抗肿瘤、调节免疫功能和刺激干扰素形成等作用；灵芝、蜂王浆具有提高免疫力、增强细胞活性之功效；牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、小球藻联用具有提高免疫力、抑制肿瘤细胞的功效；夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草具有清热解毒、抗病毒之功效。本申请通过将白花蛇舌草、灵芝、蜂王浆、河豚鱼油、牛蒡子、鱼腥草、葛根、川芎、黄柏、穿心莲、蒲公英、枸杞、贯众、虎杖、牛膝、甘草、小球藻等中草药彼此间存在复杂的相互作用关系与麦胚球蛋白和功能多糖，君臣佐使，合理配比，取得了预料不到的技术效果，使麦胚球蛋白保健口服液抗肿瘤提高免疫力的关系发生实质性改变。
具体实施方式
下面结合实施例对本发明做进一步描述：
实施例1
本发明提供一种含麦胚球蛋白的保健口服液，由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻组成。
通过以下步骤制备：
（1）分拣称量：将所用中草药分拣，去除杂质等，按照每1000份口服液中麦胚球蛋白7份、白花蛇舌草23份、竹茹多糖13份、香菇多糖13份、秋葵多糖13份、脱脂麦胚40份、灵芝6份、蜂王浆4份、牛蒡子13份、柴胡13份、鱼腥草10份、葛根12份、川芎16份、黄柏12份、夏枯草12份、穿心莲10份、黄芩10份、蒲公英13份、枸杞15份、贯众15份、虎杖7份、牛膝7份、甘草12份、小球藻13份比例称重；
（2）原料预处理：将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻处理，过30目筛；
（3）向粉碎后的混合物中加入0.3倍灭菌纯净水，接种米曲霉孢子粉和毛霉孢子粉，平摊在发酵浅盘中，厚度0.6 cm。发酵温度32 ℃，好氧发酵时间12 h后，立即50℃烘干至水分在8%左右，并进行炒制后，自然冷却至室温，得前发酵固体混合物；所述米曲霉接种为0.01%，含孢子120亿/克，毛霉接种量为0.01%，含孢子120亿/克；所述炒制温度200℃，时间30min，翻动频率在120次/分钟。
（4）将前发酵固体混合物，加0.3倍灭菌纯净水，接种0.01%红曲霉干粉，平摊在发酵浅盘中，厚度0.6cm。发酵温度37℃，发酵时间144 h，颜色为玫红色后,立即50℃烘干至水分在8%左右，得后发酵固体混合物；
（5）添加辅料：加入蜂王浆和质量分数为1～2%的甜味剂，加水搅拌定容，加热至50℃，30min；
（6）静置：将口服液半成品常温下静置48h以上；
（7）离心：将口服液半成品5000r/min离心20 min；加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖；
（8）定容分装：将离心后的口服液定容、分装即得口服液成品。
实施例2
本发明提供一种含麦胚球蛋白的保健口服液，由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻组成。
通过以下步骤制备：
（1）分拣称量：将所用中草药分拣，去除杂质等，按照每1000份口服液中麦胚球蛋白3份、白花蛇舌草15份、竹茹多糖10份、香菇多糖10份、秋葵多糖10份、脱脂麦胚30份、灵芝4份、蜂王浆6份、牛蒡子15份、柴胡10份、鱼腥草12份、葛根15份、川芎15份、黄柏13份、夏枯草13份、穿心莲8份、蒲公英15份、枸杞10份、贯众10份、虎杖5份、牛膝10份、甘草15份、小球藻10份比例称重；
（2）原料预处理：将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻混合后进行粉碎处理，过30目筛；
（3）向粉碎后的混合物中加入0.3倍灭菌纯净水，接种米曲霉孢子粉和毛霉孢子粉，平摊在发酵浅盘中，厚度0.6 cm。发酵温度32 ℃，好氧发酵时间12 h后，立即50℃烘干至水分在8%左右，并进行炒制后，自然冷却至室温，得前发酵固体混合物；所述米曲霉接种为0.01%，含孢子120亿/克，毛霉接种量为0.01%，含孢子120亿/克；所述炒制温度200℃，时间30min，翻动频率在120次/分钟；
（4）将前发酵固体混合物，加0.3倍灭菌纯净水，接种0.01%红曲霉干粉，平摊在发酵浅盘中，厚度0.6cm。发酵温度37℃，发酵时间144 h，颜色为玫红色后,立即50℃烘干至水分在8%左右，得后发酵固体混合物；
（5）添加辅料：加入蜂王浆和质量分数为1～2%的甜味剂，加水搅拌定容，加热至70℃，30min；
（6）静置：将口服液半成品常温下静置48h以上；
（7）离心：将口服液半成品5000r/min离心20 min；加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖；
（8）定容分装：将离心后的口服液定容、分装即得口服液成品。
实施例3
本发明提供一种含麦胚球蛋白的保健口服液，由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、河豚鱼油、牛蒡子、柴胡、鱼腥草、葛根、川芎、夏枯草、穿心莲、黄芩、蒲公英、贯众、虎杖、牛膝、甘草和小球藻组成。
通过以下步骤制备：
（1）分拣称量：将所用中草药分拣，去除杂质等，按照每1000份口服液中麦胚球蛋白12份、白花蛇舌草30份、竹茹多糖15份、香菇多糖15份、秋葵多糖15份、脱脂麦胚50份、灵芝8份、蜂王浆2份、牛蒡子10份、柴胡15份、鱼腥草8份、葛根10份、川芎20份、黄柏10份、夏枯草10份、穿心莲12份、蒲公英10份、枸杞16份、贯众18份、虎杖10份、牛膝5份、甘草10份、小球藻15份比例称重；
（2）原料预处理：将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻混合后进行粉碎处理，过30目筛；
（3）向粉碎后的混合物中加入0.3倍灭菌纯净水，接种米曲霉孢子粉和毛霉孢子粉，平摊在发酵浅盘中，厚度0.6 cm。发酵温度32 ℃，好氧发酵时间12 h后，立即50℃烘干至水分在8%左右，并进行炒制后，自然冷却至室温，得前发酵固体混合物；所述米曲霉接种为0.01%，含孢子120亿/克，毛霉接种量为0.01%，含孢子120亿/克；所述炒制温度200℃，时间30min，翻动频率在120次/分钟；
（4）将前发酵固体混合物，加0.3倍灭菌纯净水，接种0.01%红曲霉干粉，平摊在发酵浅盘中，厚度0.6cm。发酵温度37℃，发酵时间144 h，颜色为玫红色后,立即50℃烘干至水分在8%左右，得后发酵固体混合物；
（5）添加辅料：加入蜂王浆和质量分数为1～2%的甜味剂，加水搅拌定容，加热至70℃，30min；
（6）静置：将口服液半成品常温下静置48h以上；
（7）离心：将口服液半成品5000r/min离心20 min；加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖；
（8）定容分装：将离心后的口服液定容、分装即得口服液成品。
以上所述仅为本发明的一实施例，并不限制本发明，凡采用等同替换或等效变换的方式所获得的技术方案，均落在本发明的保护范围内。
Claims (3)
1.一种含麦胚球蛋白的保健口服液，其特征在于由麦胚球蛋白、白花蛇舌草、竹茹多糖、香菇多糖、秋葵多糖、脱脂麦胚、灵芝、蜂王浆、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻组成。
2.根据权利要求1所述的一种含麦胚球蛋白的保健口服液的制备方法，其特征在于，通过以下步骤制备：
（1）分拣称量：将所用中草药分拣，去除杂质等，按照每1000份口服液中原料质量配比：麦胚球蛋白3～12份、白花蛇舌草15～30份、竹茹多糖10～15份、香菇多糖10～15份、秋葵多糖10～15份、脱脂麦胚30～50份、灵芝4～8份、蜂王浆2～6份、牛蒡子10～15份、柴胡10～15份、鱼腥草8～12份、葛根10～15份、川芎15～20份、黄柏10～13份、夏枯草10～13份、穿心莲8～12份、黄芩8～12份、蒲公英10～15份、枸杞10～16份、贯众10～18份、虎杖5～10份、牛膝5～10份、甘草10～15份、小球藻10～15份称重；
（2）原料预处理：将白花蛇舌草、脱脂麦胚、灵芝、牛蒡子、柴胡、鱼腥草、葛根、川芎、黄柏、夏枯草、穿心莲、黄芩、蒲公英、枸杞、贯众、虎杖、牛膝、甘草和小球藻混合后进行粉碎处理，过30目筛；
（3）向粉碎后的混合物中加入0.3倍灭菌纯净水，接种米曲霉孢子粉和毛霉孢子粉，平摊在发酵浅盘中，厚度0.6 cm；发酵温度32 ℃，好氧发酵时间12 h后，立即50℃烘干至水分在8%左右，并进行炒制后，自然冷却至室温，得前发酵固体混合物；所述米曲霉接种为质量分数0.01%，含孢子120亿/克，毛霉接种量为质量分数0.01%，含孢子120亿/克；所述炒制温度200℃，时间30min，翻动频率在120次/分钟；
（4）将前发酵固体混合物，加0.3倍灭菌纯净水，接种红曲霉干粉，平摊在发酵浅盘中，厚度0.6cm；发酵温度37℃，发酵时间144 h，颜色为玫红色后,立即50℃烘干至水分在8%左右，得后发酵固体混合物；所述红曲霉接种为质量分数0.01%，含孢子80亿/克；
（5）添加辅料：加入蜂王浆和质量分数为1～2%的甜味剂，加水搅拌定容，加热至70℃，30min；
（6）静置：将口服液半成品常温下静置48h以上；
（7）离心：将口服液半成品5000r/min离心20 min；加入麦胚球蛋白、竹茹多糖、香菇多糖、秋葵多糖；
（8）定容分装：将离心后的口服液定容、分装即得口服液成品。
3.根据权利要求书1所述的一种含麦胚球蛋白的保健口服液，其特征在于，所述甜味剂的组成为三氯蔗糖1份、果糖2.5份、高果糖浆1.5份。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711106666.5A CN107753929A (zh) | 2017-11-10 | 2017-11-10 | 一种含麦胚球蛋白的保健口服液及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711106666.5A CN107753929A (zh) | 2017-11-10 | 2017-11-10 | 一种含麦胚球蛋白的保健口服液及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107753929A true CN107753929A (zh) | 2018-03-06 |
Family
ID=61272767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711106666.5A Pending CN107753929A (zh) | 2017-11-10 | 2017-11-10 | 一种含麦胚球蛋白的保健口服液及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107753929A (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112314908A (zh) * | 2020-11-02 | 2021-02-05 | 穆延东 | 一种含有花青素的蜂蜜制品 |
| CN115024494A (zh) * | 2022-07-26 | 2022-09-09 | 韩光婉 | 一种复方灵芝组合物的制备方法 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670673A (zh) * | 2012-05-21 | 2012-09-19 | 信毅投资咨询(上海)有限公司 | 秋葵活性成分在制备防治代谢性疾病的药物中的应用 |
| CN103550754A (zh) * | 2013-11-25 | 2014-02-05 | 三株福尔制药有限公司 | 一种用于辅助降血糖的益生菌发酵中药复方组合物及其制备方法和应用 |
| CN103976219A (zh) * | 2012-05-04 | 2014-08-13 | 黄家章 | 一种酒酿营养物或酿酒营养产物二步发酵制备法及用途 |
| CN105055569A (zh) * | 2015-07-22 | 2015-11-18 | 青岛浩大海洋保健食品有限公司 | 一种抗肿瘤提高免疫力鲨鱼翅骨粉中草药保健口服液及制备方法 |
| CN105477182A (zh) * | 2015-12-19 | 2016-04-13 | 青岛浩大海洋保健食品有限公司 | 一种抗肿瘤提高免疫力河豚鱼油中草药保健口服液及制备方法 |
| CN105796587A (zh) * | 2016-04-26 | 2016-07-27 | 浙江大学 | 竹茹多糖在免疫调节、抗肿瘤中的应用 |
| CN106083606A (zh) * | 2016-08-11 | 2016-11-09 | 长春海谱润斯科技有限公司 | 一种2,6‑二苯基萘衍生物及其制备方法和应用 |
| CN107029127A (zh) * | 2017-03-14 | 2017-08-11 | 广东轻工职业技术学院 | 一种具有调节血脂作用的中药制剂及其制备方法 |
-
2017
- 2017-11-10 CN CN201711106666.5A patent/CN107753929A/zh active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103976219A (zh) * | 2012-05-04 | 2014-08-13 | 黄家章 | 一种酒酿营养物或酿酒营养产物二步发酵制备法及用途 |
| CN102670673A (zh) * | 2012-05-21 | 2012-09-19 | 信毅投资咨询(上海)有限公司 | 秋葵活性成分在制备防治代谢性疾病的药物中的应用 |
| CN103550754A (zh) * | 2013-11-25 | 2014-02-05 | 三株福尔制药有限公司 | 一种用于辅助降血糖的益生菌发酵中药复方组合物及其制备方法和应用 |
| CN105055569A (zh) * | 2015-07-22 | 2015-11-18 | 青岛浩大海洋保健食品有限公司 | 一种抗肿瘤提高免疫力鲨鱼翅骨粉中草药保健口服液及制备方法 |
| CN105477182A (zh) * | 2015-12-19 | 2016-04-13 | 青岛浩大海洋保健食品有限公司 | 一种抗肿瘤提高免疫力河豚鱼油中草药保健口服液及制备方法 |
| CN105796587A (zh) * | 2016-04-26 | 2016-07-27 | 浙江大学 | 竹茹多糖在免疫调节、抗肿瘤中的应用 |
| CN106083606A (zh) * | 2016-08-11 | 2016-11-09 | 长春海谱润斯科技有限公司 | 一种2,6‑二苯基萘衍生物及其制备方法和应用 |
| CN107029127A (zh) * | 2017-03-14 | 2017-08-11 | 广东轻工职业技术学院 | 一种具有调节血脂作用的中药制剂及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 毕振原等: "麦胚球蛋白的体外抗炎活性研究", 《河南工业大学学报（自然科学版）》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112314908A (zh) * | 2020-11-02 | 2021-02-05 | 穆延东 | 一种含有花青素的蜂蜜制品 |
| CN115024494A (zh) * | 2022-07-26 | 2022-09-09 | 韩光婉 | 一种复方灵芝组合物的制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102885301B (zh) | 一种增强免疫力的组合物及其制备方法 | |
| CN1044974C (zh) | 抗乙肝药物 | |
| CN103740566B (zh) | 一种刺梨药酒及其制作方法 | |
| CN107114783A (zh) | 一种增强免疫及辅助肿瘤恢复的高硒营养补充剂 | |
| CN101455391A (zh) | 一种具有免疫调节功能的营养保健品及其制备方法 | |
| CN102144748A (zh) | 具有排毒护肝养颜功能的五色面制食品 | |
| WO2021114586A1 (zh) | 一种具有提高免疫力功能的组合物及其制备方法和应用 | |
| CN107753929A (zh) | 一种含麦胚球蛋白的保健口服液及其制备方法 | |
| CN112915181B (zh) | 一种益气复元膏方及其应用 | |
| CN103461756B (zh) | 一种供癌症患者食用的五谷杂粮全营养配方食品 | |
| CN100401918C (zh) | 一种抗疲劳的保健食品及其制备方法 | |
| CN108066384A (zh) | 一种具有增强免疫力功能的中药制剂及其制备方法 | |
| CN103053638A (zh) | 一种恢复胰岛功能消除胰岛素抵抗的面粉及其制法 | |
| CN102078600B (zh) | 抗癌复方灵芝组合物、其用途和包含其的药物组合物 | |
| CN107802698A (zh) | 增强免疫力的中药组合物及其制备方法 | |
| CN111000037A (zh) | 一种高硒辅助抗癌羊奶及其生产方法 | |
| CN107136510A (zh) | 一种提高免疫力保健食品及其制备方法 | |
| CN111778126B (zh) | 一种提高免疫力的保健酒及其制备方法 | |
| CN108450761A (zh) | 一种补气养血增强免疫的营养粉及其制备方法 | |
| CN103494912B (zh) | 一种苏黄实冲剂及其制备方法 | |
| CN107048259A (zh) | 用十三种珍贵食材配制的健康食品及其配制方法 | |
| CN102160649B (zh) | 冬虫夏草营养液及其制备方法 | |
| CN106615455A (zh) | 一种金边土元养生茶及其制备方法 | |
| CN105943829A (zh) | 一种橘红饮品及其制作方法 | |
| CN105725039A (zh) | 一种小麦复合面粉及其制备工艺 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180306 |