CN107715002A - A kind of pharmaceutical composition for treating anaphylactoid purpura and preparation method thereof - Google Patents

A kind of pharmaceutical composition for treating anaphylactoid purpura and preparation method thereof Download PDF

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CN107715002A
CN107715002A CN201711281956.3A CN201711281956A CN107715002A CN 107715002 A CN107715002 A CN 107715002A CN 201711281956 A CN201711281956 A CN 201711281956A CN 107715002 A CN107715002 A CN 107715002A
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pharmaceutical composition
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谭仁燕
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Abstract

The present invention relates to treat a kind of pharmaceutical composition of anaphylactoid purpura and preparation method thereof.The pharmaceutical composition is prepared by the Chinese medicine material of following parts by weight：Sealwort, blood party, white brills, money wind, Semen Cuscutae, lack elegant tight, the red sage root, flower of Radix Puerariae, black nightshade, the root of herbaceous peony, smilax, fir hull, semen momordicae, climb wall wind, dewdrop grass, greatly coix seed, diverging, Ivy Tree Bark, plantain seed.Pharmaceutical composition of the present invention can effectively treat anaphylactoid purpura.

Description

A kind of pharmaceutical composition for treating anaphylactoid purpura and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines for the treatment of, and in particular to a kind of pharmaceutical composition and its system for treating anaphylactoid purpura Preparation Method.
Background technology
Anaphylactoid purpura is a kind of main allergic disease for involving capillary, and clinical characters remove skin purpura Outside, often have allergic rash, painful swelling of joints, suffer from abdominal pain, have blood in stool with blood urine etc..Infection, medicine, food etc. can turn into this sick phase Pass factor.Onset is more relatively anxious, is more common in the children and youth of more than 6 years old.This disease belongs to the traditional Chinese medical science " blood trouble " category.
Heresy of this disease due to experiencing wind-heat, retention of damp-heat in the interior, the hot and suffocating skin of heat toxin, is mutually fought with qi and blood, and train of thought is hindered by blood-head, So that blood extravasation of blood, oozes between skin, product is in subcutaneous and to send out be purpura.This sick performance based on yang syndrome, heat symptom-complex, real example, If delay is with the passing of time, recurrent exerbation, internal organs qi and blood is damaged, and stasis blocking train of thought, can also appear as asthenic symptoms or simulataneous insufficiency and excessive.
1. wind-heat hinders network：The heresy of wind-heat attacks table, therefore has the exterior syndromes such as heating, foul wind, superficial and rapid pulse.The heresy of wind-heat and qi and blood phase Fight, blood extravasation of blood is then sent out as purpura.Four limbs are all sun sheet, and yang collaterals is damaged, therefore is mainly in four limbs.Red tongue body, moss thin yellow, it is Wind-heat hinder network as.
2. blood-heat bleeding：Disease early stage is common in, is lied prostrate in heat toxin, compels the absurd row of blood, oozing to survey in skin has petechia, ecchymosis.Category Real example, heat symptom-complex, therefore flushing of generating heat, it is thirsty vexed.Going out clear key then nosebleed epistaxis on blood, damage the then bleeding from the gum of stomach network, damage intestines network is then suffered from abdominal pain, Burn bladder blood network then hematuria.
3. stagnation of QI and blood：Stagnation of pathogen converted into heat, blood network of burning, recurrent exerbation, internal organs stagnation of QI-blood, therefore purpura color depth and it is red.The stasis of blood Hinder in intestines network, not general rule pain, therefore have stomachache；Stasis blocking is then shown in swelling and pain in joint.The dark violet yellow tongue fur of tongue, slippery and rapid pulse, is stagnation of QI and blood As.
4. the deficiency of liver-yin and kidney-yin：The deficiency of liver-yin and kidney-yin, deficiency-fire produced in the interior, damage of burning blood network, blood is dynamic with fire, therefore hidden when being sent out during purpura, and has tired Hot night sweat, dizziness and tinnitus etc..
The content of the invention
It is an object of the invention to provide a kind of pharmaceutical composition for treating anaphylactoid purpura；
It is a further object of the present invention to provide a kind of preparation method for the pharmaceutical composition for treating anaphylactoid purpura.
The purpose of the present invention is realized by following technical scheme：
The pharmaceutical composition for the treatment of anaphylactoid purpura of the present invention, it is prepared by the raw material of following parts by weight：
Sealwort 25-35 parts, blood party 25-35 parts, white brill 25-35 parts, money wind 25-35 parts, Semen Cuscutae 25-35 parts, scarce elegant tight 25- 35 parts, red sage root 25-35 parts, flower of Radix Puerariae 15-25 parts, black nightshade 15-25 parts, root of herbaceous peony 15-25 parts, smilax 15-25 parts, fir hull 15-25 parts, semen momordicae 15-25 parts, climb wall wind 15-25 parts, dewdrop grass 15-25 parts, coix seed 8-15 parts, big diverging 8-15 parts, Ivy Tree Bark 8-15 parts, plantain seed 8-15 parts；
Preferably, it is to be prepared by the raw material of following parts by weight：
30 parts of sealwort, 30 parts of blood party, white 30 parts of brill, 30 parts of money wind, 30 parts of Semen Cuscutae, scarce elegant tight 30 parts, 30 parts of the red sage root, the root of kudzu vine Spend 20 parts, 20 parts of black nightshade, 20 parts of the root of herbaceous peony, 20 parts of smilax, 20 parts of fir hull, 20 parts of semen momordicae, climb 20 parts of wall wind, dewdrop grass 20 Part, 10 parts of coix seed, big 10 parts of diverging, 10 parts of Ivy Tree Bark, 10 parts of plantain seed.
It is the crude drug source and primary efficacy of Chinese medicine preparation of the present invention below：
Sealwort, it is Schisandraceae Plant kadsurae coccineae Kadsura coccinea (Lem.) A.C.Smith [K.chinensisHance ex Benth；K.hainanensisMerr. root] and viticula..It is pungent；Slight bitter；It is warm-natured.The promoting flow of qi and blood circulation, swelling and pain relieving.For wind Arthritis with fixed pain caused by dampness pain, stomachache, dysmenorrhoea, the postpartum product stasis of blood, traumatic injury swelling and pain.
Blood party leaf, it is legume blood party Erythrina variegata L. and arbor blood party Erythrina Arborescens Roxb. leaf.
It is white to bore, Aquifoliaceae Holly leaf of plum Chinese ilex Ilex asprella（Hook. et Arn.） Champ. ex Benth., it is used as medicine with root, leaf.It is bitter, sweet, it is cool.It is clearing heat and detoxicating, promote the production of body fluid to quench thirst.For catching a cold, hyperpyrexia polydipsia, tonsillitis, throat Inflammation, tracheitis, pertussis, enteritis, dysentery, catarrhal jaundice, wild gill fungus, arsenic intoxication.For herbal tea primary raw material；Leaf external application, which is controlled, falls Beat damage, carbuncle furuncle poison.
Money wind, Aquifoliaceae Holly ilexrotunda Ilex rotunda Thunb. bark（Double-layer fur）, leaf, root Also can be used as medicine.Hardship, it is cool.It is clearing heat and detoxicating, swelling and pain relieving.For catching a cold, tonsillitis, abscess of throat, acute gastroenteritis, rheumatic bone Bitterly；Traumatic injury, carbuncle furuncle sore, traumatism and bleeding, burn and scald are controlled in external application.
Longan is parasitic, Santalales, Loranthaceae, shrub.Parasitize Fagaceae, Theaceae, moraceae plants or sweetgum, oil In the various plants such as paulownia, Chinese fir.It is sweet；It is bitter；It is mild-natured；Wind-damp dispelling；Filling liver kidney；Promoting blood circulation and stopping pain；Cough-relieving；Stop dysentery.Main arthralgia pain due to rheumatism；Waist Knee joint soreness；Have a dizzy spell；Alopecia；Traumatic injury；Hemorrhoid gall；Cough；Hemoptysis；Dysentery
Black nightshade, it is Moraceae ficus species ficus simplicissima Ficus simplicissima Lour. [F. hirta Vahl var. palmatiloba （Merr.）Chum], it is used as medicine with root.It is sweet, tepor.Invigorating the spleen for eliminating dampness, promoting the circulation of qi resolving sputum, relaxing tendons and activating collaterals.For lung knot Core is coughed, chronic bronchitis, rheumatic arthritis, waist-leg pain, insufficiency of the spleen edema, after being ill night sweat, leukorrhea.
It is tight to lack show, Polygalaceae polygala lacks elegant tight Polygala aureocauda Dunn, is used as medicine with root.It is sweet, micro- Hardship, put down.Tonifying Qi and blood, invigorating spleen to remove dampness, promoting blood circulation for regulating menstruation.For physically weak after being ill, soreness of waist and knee joint, traumatic injury, icteric hepatitis, kidney Scorching oedema, the prolapse of uterus, leukorrhea, irregular menstruation.
Smilax, it is the seed of babassu Chinese fan palm.It is sweet；It is bitter；It is mild-natured；Mild toxicity；It is promoting blood circulation and removing blood stasis；Softening and resolving hard mass.It is main Chronic hepatitis；A lump in the abdomen causing distension and pain
Fir hull, it is the zingiberaceous plant fir hull Alpinia katsumadai Hayata nearly mature seed of drying.It is pungent, temperature. Returns spleen, stomach.It is drying damp and strengthening spleen, warm stomach preventing or arresting vomiting.For internal retention of cold wetness, abdominal fullness and distention crymodynia, belch is vomitted inverse, do not feel like eating.
The red sage root, Piperaceae plant Hance Pepper Stem and Leaf Piper hancei Maxim. herb.Acrid flavour, it is mild-natured.Dispelling wind and eliminating dampness, strong waist Knee, swelling and pain relieving.Cure cold cough, asthma, the cold pain of stomach abdomen, treating rheumatic ostealgia, numb in every limb, waist-leg weakness, muscular atrophy, bruise Damage.
Big diverging, the drying rattan for being Piperaceae plant wind rattan Piper kadsura (Choisy) 0hwi.Acrid flavour, hardship, Slightly warm in nature.Return liver warp.Wind-damp dispelling, degrading the channel, stopping numbness pain.For wind-cold-dampness arthralgia, podomere pain, muscle arteries and veins contraction, joint stuffiness.
Semen momordicae, also known as kind son are fragrant, false camphor tree is young.The woody section medicinal herbs of Rutaceae Clausena.Latin name Clausena Excavata Burm. f. are antipyretic, removing toxic substances, admittedly lung channel, to control rheumatism, arthritis good medicine, can go miasma, control stomachache, and poison One of antidote for snakebite of snake bite.
Wall wind is climbed, for rutaceae orange Citrus reticulata Blanco and its drying and ripening of variety Pericarp.It is bitter, pungent, temperature.Return lung, the spleen channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Flower of Radix Puerariae, there is wide flower of Radix Puerariae Pogostemon cablin (Blanco)) Benth. dry aerial parts.Tepor. Returns spleen, stomach, lung channel.Eliminate dampness with aromatics, and middle preventing or arresting vomiting, deliver relieving summer-heat.For turbi damp obstructing in middle-JIAO, gastral cavity ruffian is vomitted, summer-heat and damp exterior syndrome, at the beginning of damp-warm syndrome Rise, burnout of generating heat is uncomfortable in chest not relax, and cold-dampness closes heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.
The root of herbaceous peony, it is On Polyporaceae the root of herbaceous peony Poria cocos (Schw.) Wolf dry sclerotia.It is sweet, light, it is mild-natured. The thoughts of returning home, lung, spleen, kidney channel.Clearing damp and promoting diuresis, invigorating the spleen, calming heart.For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, the heart It is refreshing uneasy, insomnia of palpitating with fear.
Dewdrop grass, it is Magnoliacea plant dewdrop grass Magnolia officinalis Rehd. et Wils. or recessed leaf horses Hoof gold Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils. drying dry hide, Root skin and branch skin.It is bitter, pungent, temperature.Returns spleen, stomach, lung, large intestine channel.Eliminating dampness dissolving phlegm, lower gas removes full.For in humidity hysteresis wound, gastral cavity ruffian to be told Rush down, stagnation of QI due to dyspepsia, abdominal distention constipation, sputum cough.
Coix seed, pulse family arbor blood party Erythrina indica Lam. bark or root skin.Hardship, put down.Return liver and kidney channel. Wind-damp dispelling, channels sootheing and network vessel quickening.For rheumatic numbness, Leg muscles pain, traumatic injury；Various stubborn dermatitis are controlled in external application.
Plantain seed, it is Rubiaceae plantain seed platymiscium plantain seed Serissa serissoides（DC.）Druce, with complete Strain is used as medicine.Light, micro-pungent, it is cool.Expelling wind to resolve the exterior, clearing heat and promoting diuresis, relaxing tendons and activating collaterals.For catching a cold, cough, toothache, acute tonsillitis, Sphagitis, acute hepatitis, chronic hepatitis, enteritis, dysentery, infantile malnutrition, Hypertension Complicated Headache, antimigraine, rheumatic arthralgia, leukorrhea；Stem Ashing eye droppings controls mist.
Ivy Tree Bark, it is rosaceous plant hairyvein agrimony Agrimonia pilosa Ledeb. dry aerial parts.Bitter, It is puckery, put down.The thoughts of returning home, Liver Channel.Astringing to arrest bleeding, preventing malaria, stop dysentery, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, bloody flux, take off power Internal lesion caused by overexertion, carbuncle sore tumefacting virus, under pruritus vulvae band.
Another aspect of the present invention there is provided the preparation method of the active component of pharmaceutical composition of the present invention, and this method is Extracted using the ethanol of water extraction or 40-80% concentration expressed in percentage by volume.Specific preparation method is as follows：
Scheme one：Whole medicinal materials, extracting in water 2-3 times are taken, each amount of water carries every time equivalent to 6-12 times of medicinal material gross weight It is 1-3 hours to take the time, merges extract solution, and filtration, relative density is 1.10-1.25 clear cream when filtrate is concentrated into 70-80 DEG C, Produce active component.
Scheme two：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, often Secondary extraction time is 1-3 hours, merges extract solution, filtration, relative density is 1.05-1.20's when filtrate is concentrated into 70-80 DEG C Clear cream, ethanol is added, it is 40-70% to make alcohol content, stands 12-24 hours, filtration, relative density when filtrate is concentrated into 70-80 DEG C For 1.10-1.25 medicinal extract, active component is produced.
Scheme three：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs, each ethanol consumption is medicinal material total amount 4-10 times, extraction time is 1-3 hours, merges extract solution, filtering, relative density is 1.10- when filtrate is concentrated into 60-80 DEG C 1.25 medicinal extract, produces active component.
The pharmaceutical composition for the treatment of anaphylactoid purpura of the present invention, can make with pharmaceutically acceptable carrier combination Into various common dosage forms, such as tablet, granule, capsule, syrup.
The pharmaceutically acceptable carrier of the present invention includes but is not limited to following：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant：Starch, sodium carboxymethyl starch, cellulose derivative, PVPP etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethanol, glycerine, propane diols, liquid paraffin, vegetable oil etc..
Flavouring：Sucrose, monose, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
A kind of pharmaceutical composition for treating anaphylactoid purpura provided by the invention has advantages below：
1st, there is pharmaceutical composition provided by the invention good expelling wind and clearing away heat, cooling blood and hemostasis, heat clearing and blood circulation promoting, kidney-nourishing qi-regulating to make With can effectively treat damp-heat type anaphylactoid purpura, total effective rate 86.4%
2nd, pharmaceutical composition preparation method of the invention is simple and easy, is adapted to basic medical unit or producer to produce in enormous quantities.
Embodiment
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate The present invention rather than limitation of the present invention.The present invention is belonged to according to the simple modifications that the essence of the present invention is carried out to the present invention Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution Volume ratio.
Embodiment 1：
Take sealwort 30g, blood party 30g, bore 30g, money wind 30g, Semen Cuscutae 30g, scarce elegant tight 30g, red sage root 30g, flower of Radix Puerariae in vain 20g, black nightshade 20g, root of herbaceous peony 20g, smilax 20g, fir hull 20g, semen momordicae 20g, climb wall wind 20g, dewdrop grass 20g, coix seed 10g, 10g, Ivy Tree Bark 10g, plantain seed 10g are dissipated greatly, extracting in water 2 times, amount of water is respectively the 10 of medicinal material gross weight twice Again, 8 times, extraction time is respectively 2 hours, 1 hour twice, merges extract solution, filtration, relative density when filtrate is concentrated into 80 DEG C For 1.10 medicinal extract.Syrup auxiliary material sucrose, sorbic acid, water are added in medicinal extract to stir, and syrup is made.
Embodiment 2：
Take sealwort 25g, blood party 25g, bore 25g, money wind 25g, Semen Cuscutae 25g, scarce elegant tight 25g, red sage root 25g, flower of Radix Puerariae in vain 15g, black nightshade 15g, root of herbaceous peony 15g, smilax 15g, fir hull 15g, semen momordicae 15g, climb wall wind 15g, dewdrop grass 15g, coix seed 8g, 8g, Ivy Tree Bark 8g plantain seed 8g are dissipated greatly, extracted 3 times with 40% alcohol reflux, each ethanol consumption is respectively medicinal material total amount 10 times, 8 times, 4 times, extraction time distinguish 3 hours, 2 hours, 1 hour, merge extract solution, filtering, when filtrate is concentrated into 60 DEG C Relative density is 1.25 medicinal extract, adds supplementary product starch, ethanol, talcum powder, and tablet is made.
Embodiment 3：
Take sealwort 25g, blood party 35g, bore 25g, money wind 35g, Semen Cuscutae 25g, scarce elegant tight 35g, red sage root 25g, flower of Radix Puerariae in vain 15g, black nightshade 25g, root of herbaceous peony 15g, smilax 25g, fir hull 15g, semen momordicae 25g, climb wall wind 15g, dewdrop grass 25g, coix seed 8g, greatly dissipate 15g, Ivy Tree Bark 15g, plantain seed 15g, extracting in water 3 times, three times amount of water be respectively equivalent to medicinal material gross weight 12 times, 8 times, 6 times, each extraction time is distinguished 3 hours, 2 hours, 1 hour, merges extract solution, filtration, and filtrate is concentrated into 70 DEG C When relative density be 1.20 clear cream, add ethanol, it is 40% to make alcohol content, stands 24 hours, and filtration, filtrate is concentrated into 70 DEG C When relative density be 1.10 medicinal extract, add that purified water ad pond om is medicinal material gross weight 3 times are filling, produce conjunction of the present invention Agent.
Embodiment 4：
Take sealwort 35g, blood party 25g, bore 35g, money wind 25g, Semen Cuscutae 35g, scarce elegant tight 25g, red sage root 35g, flower of Radix Puerariae in vain 15g, black nightshade 25g, root of herbaceous peony 15g, smilax 25g, fir hull 15g, semen momordicae 25g, climb wall wind 15g, dewdrop grass 25g, coix seed 8g, 15g, Ivy Tree Bark 15g plantain seed 15g are dissipated greatly, extracted 2 times with alcohol reflux, each concentration of alcohol is respectively 80%, 60%, Each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, and extraction time is respectively 4 hours, 3 hours, merges extract solution, mistake Filter, relative density is 1.10 medicinal extract when filtrate is concentrated into 80 DEG C, adds supplementary product starch, ethanol, talcum powder, and tablet is made.
Embodiment 5：
Take sealwort 30g, blood party 25g, bore 30g, money wind 25g, Semen Cuscutae 30g, scarce elegant tight 25g, red sage root 30g, flower of Radix Puerariae in vain 15g, black nightshade 20g, root of herbaceous peony 15g, smilax 20g, fir hull 15g, semen momordicae 20g, climb wall wind 15g, dewdrop grass 20g, coix seed 10g, dissipate 8g, Ivy Tree Bark 8g, plantain seed 8g greatly, extracting in water 3 times, three times amount of water be respectively 12 times of medicinal material gross weight, 8 Again, 6 times, extraction time is respectively 3 hours, 2 hours, 1 hour three times, merges extract solution, filtration, and filtrate is concentrated into 70 DEG C of phases To the clear cream that density is 1.25, supplementary product starch, ethanol, dextrin, magnesium stearate are added, loads capsule shells, capsule is made.
Embodiment 6：
Take sealwort 35g, blood party 35g, bore 35g, money wind 35g, Semen Cuscutae 35g, scarce elegant tight 35g, red sage root 35g, flower of Radix Puerariae in vain 25g, black nightshade 25g, root of herbaceous peony 25g, smilax 25g, fir hull 25g, semen momordicae 25g, climb wall wind 25g, dewdrop grass 25g, coix seed 15g, 15g, Ivy Tree Bark 15g, plantain seed 15g are dissipated greatly, extracting in water 2 times, each amount of water is respectively equivalent to medicinal material gross weight 12 times, 10 times, each extraction time is respectively 3 hours, 2 hours, merges extract solution, filtration, filtrate is concentrated into phase at 80 DEG C To the clear cream that density is 1.05, ethanol is added, it is 70% to make alcohol content, stands 12 hours, and filtration, filtrate is concentrated into 70 DEG C of phases To the medicinal extract that density is 1.25, auxiliary material Icing Sugar, starch, dextrin, ethanol are added, granule is made.
Embodiment 7：
Weigh sealwort 30g, blood party 30g, bore 30g, money wind 30g, Semen Cuscutae 30g, scarce elegant tight 30g, red sage root 30g, flower of Radix Puerariae in vain 20g, black nightshade 20g, root of herbaceous peony 20g, smilax 20g, fir hull 20g, semen momordicae 20g, climb wall wind 20g, dewdrop grass 20g, coix seed 10g, 10g, Ivy Tree Bark 10g, plantain seed 10g are dissipated greatly, cleaned, dry, crush, produce pulvis of the present invention.
Embodiment 8
Tablet prepared by the embodiment of the present invention 4, it is oral to give patients with anaphylactoid purpura, 2 every time, 3 times a day, before meals With clinical data is as follows：
Disorder class Illness number of cases The course of disease Treatment time Efficiently individual quantity Total effective rate
Anaphylactoid purpura 66 - 2 years January 10-15 days 57 people 86.4%
Embodiment 9
Temperature certain, female, 29 years old, patients with anaphylactoid purpura thighs, shank played needle point to the granular big aubergine fash of grain, comparatively dense point Cloth, colour-fast 20 days of slide pressure, that touches was scorching hot.Once hormone, calcium agent, vitamin C etc. were taken, fash still reproduces repeatedly.Award this Inventive embodiments 3 are treated, and purpura starts to disappear after 3 days, and fash totally disappeared after 12 days, and all diseases are cured.Follow-up is not sent out after two months.
Although above the present invention is made to retouch in detail with general explanation, embodiment and experiment State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art 's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed Scope.

Claims (7)

1. a kind of pharmaceutical composition for treating anaphylactoid purpura, it is characterised in that it is prepared by the raw material of following parts by weight 's：Sealwort 25-35 parts, blood party 25-35 parts, white brill 25-35 parts, money wind 25-35 parts, Semen Cuscutae 25-35 parts, scarce elegant tight 25- 35 parts, red sage root 25-35 parts, flower of Radix Puerariae 15-25 parts, black nightshade 15-25 parts, root of herbaceous peony 15-25 parts, smilax 15-25 parts, fir hull 15-25 parts, semen momordicae 15-25 parts, climb wall wind 15-25 parts, dewdrop grass 15-25 parts, coix seed 8-15 parts, big diverging 8-15 parts, Ivy Tree Bark 8-15 parts, plantain seed 8-15 parts.
2. pharmaceutical composition according to claim 1, it is characterised in that it is prepared by the raw material of following parts by weight 's：30 parts of sealwort, 30 parts of blood party, white 30 parts of brill, 30 parts of money wind, 30 parts of Semen Cuscutae, scarce elegant tight 30 parts, 30 parts of the red sage root, the root of kudzu vine Spend 20 parts, 20 parts of black nightshade, 20 parts of the root of herbaceous peony, 20 parts of smilax, 20 parts of fir hull, 20 parts of semen momordicae, climb 20 parts of wall wind, dewdrop grass 20 Part, 10 parts of coix seed, big 10 parts of diverging, 10 parts of Ivy Tree Bark, 10 parts of plantain seed.
3. pharmaceutical composition as claimed in claim 1 or 2, it is characterised in that its active component is to use water extraction or 40-80% What the ethanol extraction of concentration expressed in percentage by volume was prepared.
4. pharmaceutical composition as claimed in claim 3, it is characterised in that its active component be prepared by the following method and Into：Whole medicinal materials are taken, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time For 1-3 hours, merge extract solution, filtration, relative density is 1.10-1.25 clear cream when filtrate is concentrated into 70-80 DEG C, is produced The active component.
5. pharmaceutical composition as claimed in claim 3, it is characterised in that its active component be prepared by the following method and Into：Whole medicinal materials are taken, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, each extraction time For 1-3 hours, merge extract solution, filtration, relative density is 1.05-1.20 clear cream when filtrate is concentrated into 70-80 DEG C, adds second Alcohol, it is 40-70% to make alcohol content, stands 12-24 hours, and filtration, relative density is 1.10-1.25 when filtrate is concentrated into 70-80 DEG C Medicinal extract, produce the active component.
6. pharmaceutical composition as claimed in claim 3, it is characterised in that its active component be prepared by the following method and Into：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs, each ethanol consumption is 4-10 times of medicinal material total amount, is extracted Time is 1-3 hours, merges extract solution, filtering, relative density is 1.10-1.25 medicinal extract when filtrate is concentrated into 60-80 DEG C, i.e., Obtain the active component.
7. the pharmaceutical composition of anaphylactoid purpura is treated, by the pharmaceutical composition of the treatment anaphylactoid purpura of claim 1 or 2 It is prepared into acceptable carrier combination in pharmaceuticals industry.
CN201711281956.3A 2017-12-07 2017-12-07 A kind of pharmaceutical composition for treating anaphylactoid purpura and preparation method thereof Pending CN107715002A (en)

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Publication number Priority date Publication date Assignee Title
CN101953936A (en) * 2010-09-19 2011-01-26 姜红 Traditional Chinese medicine preparation for treating immune thrombocytopenia and preparation method thereof
CN104784419A (en) * 2015-04-24 2015-07-22 陕西郝其军制药股份有限公司 Traditional Chinese medicine composition for treating immune thrombocytopenic purpura and preparation method of traditional Chinese medicine composition

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Publication number Priority date Publication date Assignee Title
CN101953936A (en) * 2010-09-19 2011-01-26 姜红 Traditional Chinese medicine preparation for treating immune thrombocytopenia and preparation method thereof
CN104784419A (en) * 2015-04-24 2015-07-22 陕西郝其军制药股份有限公司 Traditional Chinese medicine composition for treating immune thrombocytopenic purpura and preparation method of traditional Chinese medicine composition

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