CN107714834A - A kind of composition of camellia oil preparation for external use, preparation method and applications - Google Patents
A kind of composition of camellia oil preparation for external use, preparation method and applications Download PDFInfo
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention discloses a kind of composition of camellia oil preparation for external use, preparation method and applications, it is characterized in that being prepared by raw material according to the following percentages by weight and pharmaceutically acceptable carrier：90~99 parts of camellia oil, 1~10 part of truestar anisetree essential oil.Its formulation is cream, emulsion, liniment, liposome, essential oil or spray.The present invention can be used for treatment skin pressure ulcer prevention and auxiliary treatment, treatment and prevention neonate diaper dermatitis, xerodermia and risk zones skin surface disease, have the effect such as anti-inflammatory, antiallergy, antibacterial, moisturizing, and significant effect.
Description
Technical field
The present invention relates to external preparation technical field, especially a kind of composition of camellia oil preparation for external use, preparation method
And its application.
Background technology
Skin pressure ulcer, pressure ulcer, abbreviation PU, pressure sore is also cried, referred to by pressure, frictional force, shearing
Ischemic necrosis skin lesion caused by power and dipping.Clinical symptoms is:(1) it is painless；(2) edge is dried firmly, and profile is normal
Rounded or crateriform；(3) expand from epidermis and prolong to subcutaneous and deep tissue, there is crack to hand over it to be separated into several parts, be not easy
Fully drainage；(4) granulation tissue for being distributed in ulcer bed is in canescence, foul smelling secretion or purulent secretion during with scabies secondary infection
Logistics goes out, and penetrates deep tissue, makes a strand tendon, periosteum inflammation, thickening, hardening, and destroy its sclerotin and joint.Pressure ulcer week
Phase is up to even several years several months.It is refractory according to the investigation statisticses report in 2002 of U.S.'s health care policy and research institution (AHCPR)
Conjunction property pressure ulcers have become one of direct cause of death of paraplegia patient, account for the 7~8% of paraplegia patient.
Ordinary type ichthyosis (ichthyosis vulgaris) state of an illness the lighter is showed only as winter dry skin, and surface has
The chaff sample scales of skin that peel off in small, broken bits, also known as asteatosis cutis (xeroderma), general weight summer in winter are light.Infant can fall ill.Involve lower limb to stretch more
Side, especially the most notable with shank, four limbs bend side and gauffer position is not involved more.Typical skin lesion be it is filbert to dark brown rhombus or
The polygonal scales of skin that peel off, the set of scales of skin that peel off center, edge dissociate, and buttocks and four limbs stretch side and can have hair follicle keratotic papule；Slap the common line of plantar
Shape is chapped and palmmprint is deepened；Usual no conscious sympton, the disease is mainly caused by heredity.
Children are red, and stern is also referred to as diaper dermatitis, is a kind of common and multiple skin lesion disease of neonatal period, in category
" flooding nine sores ", " monkey sore ", " urine stove is red " category are cured, cardinal symptom is buttocks and the skin of diaper contact position in red, swollen shape
And with fash, or even there is sepage, excoriation, phenomenon of festering in some, slight friction or bruising will damage.If no
Timely and effectively treat, easily cause bacterium infection and concurrent infection, so as to have a strong impact on the health of infant.
At present, antibacterial drug therapy is mainly clinically taken for above-mentioned skin disease, kills bacterium, ensure skin regeneration.
Although antibacterial drug therapy can obtain certain effect, antibacterials on the one hand there is the serious side effect such as allergy,
The problem of additionally there are a drug resistance getting worse.
Camellia oil obtains from Theaceae (Camellia) oil tea (Camellia oleiferaAbel) seeds,
It is one of most ancient woody edible vegetable oil in China.Unrighted acid is up to more than 90% in camellia oil, and oleic acid reaches 80
~83%, linoleic acid reaches 7~13%, and is rich in protein and vitamin A, B, D, E etc., the abundant Asia especially contained by it
Numb acid is needed by human and can not synthesized, and is described as " east olive oil ".Camellia oil is mainly used in fully natural green at present
Edible oil, category " treasure in oil ".《Chinese Pharmacopoeia》(nineteen ninety-five version) is recorded tea oil as medicinal oil, and tea oil is because it is rich in a variety of
Nutritional ingredient, for oral administration, external application have good effectiveness.Tea oil plays the role of clearing away heat and eliminating dampeness, desinsection removing toxic substances, can prevent skin scabies
Itch, chronic eczema.
Germany《Women》Biweekly once with《The secret of tea oil》Australian is published for topic to be prevented and treated with camellia oil
Flu, bronchitis, have a throat-ache, sprain, hurting, many illnesss such as sore or sore rash caused by poisonous insect bites, saying mountain oil tea is oily
Into " miraculous cure ".《Agricultural administration book》In there is tea oil to treat hemorrhoid, move back damp and hot record；《Detailed outline is picked up any lost article from the road》Say, camellia oil can
Ease constipation, clearing stomach and detoxicating, killing bacteria.There are some researches show camellia oil has preferable antibacterial, insecticidal activity and Green Tea Extract oxygen in recent years
Change acts on, and has good protective effect to skin and mucous membrane.Therefore, camellia oil is developed into as green, natural externally applied medicine
Thing preparation has good prospect.
Anise is Magnoliaceae anise platymiscium Chinese anise Illicium verum Hook.f. fruit, is China south
The important economic tree in side, medicine-food two-purpose, is widely used in food industry as spice.Anise fresh fruit contains volatile oil 2.5
~3%, its dry mature fruit contains volatile oil about 8~9%, and master is containing flavone compound, organic acid compound in fruit.
Pharmacological research shows that anise water decoction has bacteriostasis to Bacillus tuberculosis and hay bacillus.Ethanol extract is to golden yellow
Color staphylococcus, pneumococcus, corynebacterium diphtheriae, hay bacillus, comma bacillus, typhoid bacillus, paratyphosum Bacterium, shigella dysenteriae,
Escherichia coli and common pathogen have stronger inhibitory action.Alcohol extracting thing is (golden yellow to gram-positive bacterium in vitro
Staphylococcus.Pneumococcus, corynebacterium diphtheriae etc.) Bacteriostasis effects it is similar to 20 units of potassium salt of penicillin/ml；To Gram-negative
The bacteriostasis and sulfuric acid strepto- of bacterium (hay bacillus, Escherichia coli, V.cholerae and typhoid fever, paratyphoid, shigella dysenteriae etc.)
Element 50 units/ml is similar；1% benzoic acid and salicylic acid are more than to the bacteriostasis of fungi.
The present inventor has found its composition to treating skin pressure to camellia oil and truestar anisetree essential oil research process
Ulcer is prevented and auxiliary treatment, treatment have with prevention neonate diaper dermatitis, xerodermia and risk zones skin surface disease
Unexpected therapeutic effect.Said composition and application have no report.
The content of the invention
It is an object of the invention to provide a kind of composition of camellia oil preparation for external use and preparation method thereof, it is applied to skin
Scorching class prevention and treatment of diseases, there is the effect such as anti-inflammatory, antiallergy, antibacterial.
First purpose of the present invention is achieved through the following technical solutions：
A kind of composition of camellia oil preparation for external use, raw material according to the following percentages by weight are prepared：
90~99 parts of camellia oil,
1~10 part of truestar anisetree essential oil.
Preferably, a kind of composition of camellia oil preparation for external use, raw material according to the following percentages by weight are prepared：
95~99 parts of camellia oil,
1~5 part of truestar anisetree essential oil.
It is further preferable that a kind of composition of camellia oil preparation for external use, raw material according to the following percentages by weight are prepared：
99 parts of camellia oil,
1 part of truestar anisetree essential oil.
Described camellia oil preparation for external use, is prepared by the raw material and pharmaceutically acceptable carrier, and its formulation is
Cream, emulsion, liniment, liposome, essential oil or spray.
Second object of the present invention is to provide a kind of preparation method of camellia oil preparation for external use, comprises the following steps：
(1) truestar anisetree essential oil extracts：Fresh anise is placed in 10~30s of holding under 1~10MPa condition of high voltage, then
It is evacuated to 1~10Pa and maintains the vacuum to obtain dried material to material water ratio≤7%；Added into dried material
The water of 0.3~0.6 times of its weight, 2~3h is distilled at 40~60 DEG C, in still-process, dried object is weighed less than when water
Expect during 0.3 times of weight that cooling recovered steam, stratification, upper strata is, it is necessary to add water to 0.3~0.6 times of dried material
Truestar anisetree essential oil.
2) prepared by camellia oil：Benevolence is full for selection, free from insect pests, without going mouldy and the tea seed of peculiar smell, shelled after steam drying,
Tea seed after shelling is sent into the squeezing of cold pressing machine, filtering, entered salt solution is added while stirring in filtrate feeding alkali-refining pot
Row neutralization reaction, stand 24~48h, take be dehydrated after the washing of upper strata edible vegetable oil salt, decolourize, be deodorized, dewaxing produces.
3) camellia oil and truestar anisetree essential oil of prescription parts by weight are taken, according to required formulation, is added in dermatology or pharmaceutically
It is prepared by acceptable carrier.
The camellia oil preparation for external use is preparing treatment skin pressure ulcer (such as 1 phase erythema, II phases unbroken blister
Phase skin) prevention and auxiliary treatment, treatment is with preventing neonate diaper dermatitis, xerodermia and risk zones skin surface disease
Using.
Compared with prior art, the invention has the advantages that：
(1) previous experiments research confirms, camellia oil and truestar anisetree essential oil are respectively in treatment skin pressure ulcer (such as 1 phase
Erythema, II phases unbroken blister phase skin) prevention and auxiliary treatment, treatment with prevent neonate diaper dermatitis, xerodermia and
There is the effect of preferable in terms of risk zones skin surface disease.On this basis, the present invention has converged anti-inflammatory, the antibacterial of the two
Effect, the two composition and effect intersect, cooperateed with, and curative effect is more excellent.The present invention has that preparation technology is simple, drug quality is uniform
The advantages that stable, can effectively prevent and treat the disease such as skin pressure ulcer and neonate diaper dermatitis, xerodermia, to various bacteria and
Fungi has suppression and/or killing action, while has the function that good holding moisture of skin and moisten.
(2) present invention first expands rapidly anise fresh fruit, forms alveolate texture so that volatile oil is in follow-up distillation
It is easy to vapor to take away, steam distillation temperature can be substantially reduced, and ensures that active ingredient is not by high temperature in anise.
The addition of still-process reclaimed water is only 0.3~0.6 times of dried material, the addition of water when being distilled well below conventional steam
Amount, can so ensure that caused vapor is relatively fewer in heating process, only take away relatively low trans of molecular weight
~anisole, cis-anethole, chavicol methyl ether and anisaldehyde, and the essential oil of HMW is avoided as vapor carries, so as to really
Protect the quality of the truestar anisetree essential oil of extraction.
Embodiment
Limited with reference to specific embodiment technical scheme is further, but claimed
Scope is not only limited to made description.
Embodiment one
A kind of camellia oil medicinal external emulsifiable paste agent component is as follows：
A kind of preparation method of camellia oil medicinal external emulsifiable paste agent, comprises the following steps：
(1) truestar anisetree essential oil extracts：Fresh anise is placed under 6MPa condition of high voltage and keeps 20s, is then evacuated to
6Pa simultaneously maintains the vacuum to obtain dried material to material water ratio≤7%；0.4 times of its weight is added into dried material
Water, 2.5h is distilled at 50 DEG C, in still-process, when 0.3 times that weighs less than dried material weight of water, it is necessary to plus water
To 0.4 times of dried material, recovered steam is cooled down, stratification, upper strata is truestar anisetree essential oil.
2) prepared by camellia oil：Benevolence is full for selection, free from insect pests, without going mouldy and the tea seed of peculiar smell, shelled after steam drying,
Tea seed after shelling is sent into the squeezing of cold pressing machine, filtering, entered salt solution is added while stirring in filtrate feeding alkali-refining pot
Row neutralization reaction, stand 35h, take be dehydrated after the washing of upper strata edible vegetable oil salt, decolourize, be deodorized, dewaxing produces.
3) after stearic acid, lanolin being mixed and heated into 90 DEG C, 70 DEG C of addition camellia oils, truestar anisetree essential oils is cooled to and are stirred
It is even, as oil phase；Purified water and glycerine are taken, is heated to 90 DEG C, triethanolamine is added, is cooled to 70 DEG C；Miscella aqueous phase；Mixing
Mode can add aqueous phase with oil phase, can also aqueous phase addition oil phase；Antioxidant, preservative are added, stirs and evenly mixs, is cooled to 45
DEG C, produce.
The agent of camellia oil medicinal external emulsifiable paste is preparing treatment skin pressure ulcer (such as 1 phase erythema, the II phases unbroken blister phase
Skin) prevention and auxiliary treatment, treatment and prevention neonate diaper dermatitis, xerodermia and risk zones skin surface disease answer
With.
Embodiment two
A kind of camellia oil external essence oil component is as follows：
Camellia oil 90g
Truestar anisetree essential oil 10g
Preservative 0.2g
A kind of preparation method of camellia oil medicinal external emulsifiable paste agent, comprises the following steps：
(1) truestar anisetree essential oil extracts：Fresh anise is placed under 10MPa condition of high voltage and keeps 30s, is then evacuated to
10Pa simultaneously maintains the vacuum to obtain dried material to material water ratio≤7%；0.6 times of its weight is added into dried material
Water, 3h is distilled at 60 DEG C, in still-process, when 0.3 times that weighs less than dried material weight of water, it is necessary to plus water
To 0.6 times of dried material, recovered steam is cooled down, stratification, upper strata is truestar anisetree essential oil.
2) prepared by camellia oil：Benevolence is full for selection, free from insect pests, without going mouldy and the tea seed of peculiar smell, shelled after steam drying,
Tea seed after shelling is sent into the squeezing of cold pressing machine, filtering, entered salt solution is added while stirring in filtrate feeding alkali-refining pot
Row neutralization reaction, stand 48h, take be dehydrated after the washing of upper strata edible vegetable oil salt, decolourize, be deodorized, dewaxing produces.
3) each component is weighed by above-mentioned metering ratio, be uniformly mixed, you can camellia oil external essence oil is made.
Camellia oil external essence oil is preparing treatment skin pressure ulcer (such as 1 phase erythema, II phases unbroken blister phase skin
Skin) prevention and auxiliary treatment, treatment and prevention neonate diaper dermatitis, xerodermia and risk zones skin surface disease answer
With.
Embodiment three
A kind of camellia oil spray component is as follows：
A kind of preparation method of camellia oil medicinal external emulsifiable paste agent, comprises the following steps：
(1) truestar anisetree essential oil extracts：Fresh anise is placed under 1MPa condition of high voltage and keeps 10s, is then evacuated to
1Pa simultaneously maintains the vacuum to obtain dried material to material water ratio≤7%；0.3 times of its weight is added into dried material
Water, 2h is distilled at 40 DEG C, in still-process, when 0.3 times that weighs less than dried material weight of water, it is necessary to add water to
0.3 times of dried material, recovered steam is cooled down, stratification, upper strata is truestar anisetree essential oil.
2) prepared by camellia oil：Benevolence is full for selection, free from insect pests, without going mouldy and the tea seed of peculiar smell, shelled after steam drying,
Tea seed after shelling is sent into the squeezing of cold pressing machine, filtering, entered salt solution is added while stirring in filtrate feeding alkali-refining pot
Row neutralization reaction, stand 24h, take be dehydrated after the washing of upper strata edible vegetable oil salt, decolourize, be deodorized, dewaxing produces.
3) camellia oil and truestar anisetree essential oil are weighed by prescription, adds Tween-80, fully mix, add water and continue to mix, make
Into spray.
Camellia oil spray is preparing treatment skin pressure ulcer (such as 1 phase erythema, II phases unbroken blister phase skin
Skin) prevention and auxiliary treatment, treatment and prevention neonate diaper dermatitis, xerodermia and risk zones skin surface disease answer
With.
The skin sensibiligen of test example 1 is tested
Experimental method：Select healthy kunming mice 24, male and female half and half.Before experiment 24h by the ㎝ of mouse back shaving 3 ×
3 ㎝, 3 groups, i.e. intact skin control group, intact skin administration group, damaged skin administration group are randomly divided into, it is every group 8, every small
Mouse is weighed.The making of damaged skin, local scratch is caused with fine sandpaper friction, using local oozing of blood as degree.Control group is non-process
Invention formulation is uniformly applied to back unhairing intact skin region by group, intact skin administration group, and damaged skin administration group is
Invention formulation is uniformly applied to back unhairing damaged skin region.It is local daily to be administered 2 times, washed away before smearing every time with warm water
Tested material, observation, then smears identical tested material, continuous 14 days.Observe daily whether have to animal after tested material it is local and complete
Body poisoning manifestations and death condition：Including behavioral activity, motion state, to extraneous stimulate the reaction (easily excited, irritability), take the photograph
Food situation (not ingesting, food, food refusal less), stool situation (diarrhoea, constipation, excrement is shapeless, color and luster is abnormal etc.), skin and hair
(color, tension force~hair fluffy, perpendicular hair), ordinary circumstance (become thin, abnormal posture etc.).Dead mouse anatomic observation pathomorphism
Learn change；After 14 days, survival mice is weighed and anatomic observation morphological change.
Experimental result：Intact skin acute toxicity testing group mouse skin is without redness, no death, survival mice solution after 14 days
Cut open, observe morphology and have no significant change；Visible red and swollen, incrustation after the scratch of damaged skin acute toxicity testing group mouse skin,
Surrounding skin is without redness, decrustation after 5 days, and significant change is had no without death, dissection, observation morphology after 14 days.
The single-dose of test example 2, the skin irritation test of multiple dosing
Experimental method：The skin irritation test selection kunming mice 16 of single-dose, male and female half and half.Before experiment
24h is complete by mouse back backbone both sides shaving 9c ㎡, holding skin.8 mouse are taken, using androgynous left and right sides self-contrast,
Left side goes to hair-fields to apply by reagent invention formulation, right side go hair-fields apply matrix (i.e. this prescription remove camellia oil and truestar anisetree essential oil it
Outer matrix), and fixed with nonirritant gauze and bandage.After coating 24h, left drug is washed away with warm water, is removed
1h after test medicine, 24h, 48h, 72h visually observe dermoreaction；Another 8 mouse, shaving is caused with fine sandpaper friction during experiment
Area locally abrades, and using local oozing of blood as degree, the damaged degree of left and right sides skin should be basically identical.Coating method, dosage and sight
Index is examined with intact skin irritant experiment group.Result of the test scores by skin wound repair standards of grading, calculates mean scores,
Carry out stimulus intensity evaluation.
The skin irritation test experimental method of multiple dosing is still carried out with observational technique by single administration experiment, but daily
Administration 2 times, continuous 7 days, 1h, 24h, 48h after test medicine are removed, 72h visually observes dermoreaction, records erythema and oedema feelings
Condition, as a result scored by skin wound repair standards of grading, calculate mean scores, carry out stimulus intensity evaluation.
Skin irritation reacts score criteria：Erythema:It is 0 point without erythema, is visible as 1 point reluctantly, hence it is evident that 2 points are visible as,
Severe erythema is 3 points, and aubergine erythema is 4 points.Oedema:It is 0 point without oedema, is visible as 1 point reluctantly, it is seen that (edge is higher by week
Enclose skin) it is 2 points, cutaneous protuberance about 1mm and profile understand that simultaneously scope expands as 4 points to oedema protuberance more than 1mm for 3 points.
Skin irritatin intensity evaluation standard：Stimulus index average value=(erythema total score+oedema total score)/animal number, point
Value ＜ 0.5 is nonirritant；Score value ＜ 2.0 is slight stimulation；Score value ＜ 6.0 is moderate excitant；Score value ＞ 6.0 is strong thorn
Swash property.
Experimental result：
As a result show, in experimental animal intact skin stimulation test, without red after smearing invention formulation 24,48,72h
Spot and oedema occur, and identical with matrix control group side, the equal ＜ 0.5 of average stimulate the reaction score value at two groups of each time points divides；In reality
Test in animal damaged skin stimulation test, after invention formulation is smeared in skin injury area, in addition to having scratch incrustation, with Matrix controls
Group side is identical, and the equal ＜ 0.5 of average stimulate the reaction score value at two groups of each time points divides.Invention formulation is prompted to complete and damaged skin
Skin is nonirritant in the case of single-dose, is shown in Table 1, table 2.
The reaction score value that the invention formulation single medication of table 1 is stimulated mouse skin
Stimulus intensity index of the invention formulation single medication of table 2 to mouse skin
The skin irritation test result of multiple dosing shows, invention formulation group with after matrix group multiple dosing, completely
The average response score value no significant difference of skin and damaged skin, two groups of response stimulus intensity to intact skin and damaged skin
The equal ＜ 0.5 of score value divides, prompt invention formulation to complete and damaged skin in the case of multiple dosing it is nonirritant, be shown in Table
3rd, table 4.
The reaction score value that the multiple medication of the invention formulation of table 3 is stimulated mouse skin
Stimulus intensity index of the multiple medication of the invention formulation of table 4 to mouse skin
For the present invention to complete and damaged skin in the case of single-dose and multiple dosing, response stimulus intensity score value is equal
＜ 0.5 divides, i.e., nonirritant.
The anti-inflammation test of test example 3
Test method：The similar healthy kunming mice 24 of body weight, age in days is chosen, is divided into reagent group, feminine gender at random
Control group (painting distilled water), positive controls (emulsion of hydrocortisone butyrate).0.1ml dimethylbenzene is taken to be applied to each mouse auris dextra respectively
Front and rear two sides causes inflammation, is uniformly smeared in auris dextra with the medicine of same volume respectively after causing inflammation, was measured after 4 hours and causes scorching auricle thickness
Degree, calculate inflammation swelling and swelling inhibiting rate.
The invention formulation paraxylene of table 5 causes the influence (x ± s) of mice auricle swelling
Result of the test：As can be seen from the results of table 5, invention formulation and butyric acid hydrocortisone can substantially reduce mouse ear and swell
Expansibility, swelling inhibiting rate are respectively 56.37%, 49.26%.Compared with model control group, invention formulation group and butyric acid hydrogenation
The ear swelling degree difference of cortisone group has significant (P<0.01), invention formulation and butyric acid hydrocortisone can be bright
It is aobvious to mitigate mice ear degree, prompt invention formulation to have certain antagonism to Acute irritation test contact dermatitis.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not limited to the substantial technological content of the present invention
Scope, substantial technological content of the invention are broadly to be defined in the right of application, any skill that other people complete
Art or method, if with claims hereof scope defined in a kind of identical, or simply equivalent replacement,
It is considered as being covered by among the right.
Claims (6)
1. a kind of composition of camellia oil preparation for external use, be in place of its feature, raw material according to the following percentages by weight prepare and
Into：
90~99 parts of camellia oil,
1~10 part of truestar anisetree essential oil.
2. the composition of camellia oil preparation for external use as claimed in claim 1, it is characterised in that original according to the following percentages by weight
Material is prepared：
95~99 parts of camellia oil,
1~5 part of truestar anisetree essential oil.
3. the composition of camellia oil preparation for external use as claimed in claim 1, it is characterised in that original according to the following percentages by weight
Material is prepared：
99 parts of camellia oil,
1 part of truestar anisetree essential oil.
4. the composition of the camellia oil preparation for external use as described in any one of claims 1 to 3, it is characterised in that by the raw material
It is prepared with pharmaceutically acceptable carrier, its formulation is cream, emulsion, liniment, liposome, essential oil or spray.
5. a kind of preparation method of camellia oil preparation for external use, its feature part is, comprises the following steps：
(1) truestar anisetree essential oil extracts：Fresh anise is placed in 10~30s of holding under 1~10MPa condition of high voltage, then taken out true
Sky is to 1~10Pa and maintains the vacuum to obtain dried material to material water ratio≤7%；It is heavy that its is added into dried material
The water of 0.3~0.8 times of amount, 2~3h is distilled at 40~60 DEG C, in still-process, dried material weight is weighed less than when water
, it is necessary to add water to 0.3~0.8 times of dried material at 0.3 times of amount, recovered steam is cooled down, stratification, upper strata is anise
Essential oil.
(2) prepared by camellia oil：Benevolence is full for selection, free from insect pests, without going mouldy and the tea seed of peculiar smell, shelled after steam drying, will
Tea seed after shelling is sent into the squeezing of cold pressing machine, filtering, filtrate is sent into alkali-refining pot and adds salt solution progress while stirring
Neutralization reaction, stand 24~48h, take be dehydrated after the washing of upper strata edible vegetable oil salt, decolourize, be deodorized, dewaxing produces.
(3) camellia oil and truestar anisetree essential oil of prescription parts by weight are taken, according to required formulation, adds in dermatology or can pharmaceutically connect
It is prepared by the carrier received.
6. a kind of camellia oil preparation for external use is preparing treatment skin pressure ulcer, neonate diaper dermatitis, xerodermia and risk
Application in terms of the prevention of area skin surface disease and auxiliary treatment.
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Cited By (1)
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| CN110420242A (en) * | 2019-07-25 | 2019-11-08 | 南京中医药大学 | A kind of development of novel antipruritic essential oil |
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