CN107693524A - A kind of preparation method containing aspirin and clopidogrel - Google Patents

A kind of preparation method containing aspirin and clopidogrel Download PDF

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Publication number
CN107693524A
CN107693524A CN201710995638.7A CN201710995638A CN107693524A CN 107693524 A CN107693524 A CN 107693524A CN 201710995638 A CN201710995638 A CN 201710995638A CN 107693524 A CN107693524 A CN 107693524A
Authority
CN
China
Prior art keywords
clopidogrel
aspirin
preparation
layer
stomach
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201710995638.7A
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Chinese (zh)
Inventor
罗铭炽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201710995638.7A priority Critical patent/CN107693524A/en
Publication of CN107693524A publication Critical patent/CN107693524A/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention discloses a kind of preparation method containing aspirin and clopidogrel, a kind of preparation method containing aspirin and clopidogrel, comprises the following steps：S1 prepares aspirin layer inner core；S2 is coated to aspirin layer inner core, and then obtains enteric layer；S3 is coated to enteric layer, and then obtains clopidogrel or its medicinal salt deposit；S4 is coated to clopidogrel or its medicinal salt deposit, and then obtains layer soluble in the stomach, and is pressed into the tablet containing aspirin and clopidogrel；Beneficial effect：Beneficial effect：Tablet prepared by a kind of preparation method of the tablet containing aspirin and clopidogrel of the present invention can effectively treat pathological condition, angiocarpy and the cerebrovascular system disease induced by platelet aggregation, and to coat of the stomach not damaged, be advantageous to the clothes for patients use to aspirin intolerance.

Description

A kind of preparation method containing aspirin and clopidogrel
Technical field
The present invention relates to pharmaceutical arts, more particularly to a kind of preparation side of the tablet containing aspirin and clopidogrel Method.
Background technology
The current medicament comprising aspirin and clopidogrel is generally the shape of tablet, gel capsule or single dose bag Formula, then Aspirin tablet may cause coat of the stomach to damage in the form of the above, prepare a kind of new above-mentioned tablet and overcome The defects of causing coat of the stomach to damage is actually necessary.
The content of the invention
It is an object of the invention to provide a kind of preparation method of the tablet containing aspirin and clopidogrel, to solve The shortcomings that easily causing coat of the stomach to damage in the prior art.
Technical scheme:
A kind of preparation method containing aspirin and clopidogrel, comprises the following steps：
S1. aspirin layer inner core is prepared；
S2. aspirin layer inner core is coated, and then obtains enteric layer；
S3. enteric layer is coated, and then obtains clopidogrel or its medicinal salt deposit；
S4. clopidogrel or its medicinal salt deposit are coated, and then obtain layer soluble in the stomach, and be pressed into containing aspirin and chlorine pyrrole The tablet of Gray.
The aspirin layer inner core includes acetylsalicylic acid or its pharmaceutical salts.
The layer soluble in the stomach includes at least one stomach tolerance polymer and the weight at least 15% of polymer is resistant to relative to stomach Sodium bicarbonate.
The enteric layer includes hydroxypropyl ethyl cellulose and POLYPROPYLENE GLYCOL.
Beneficial effect：Tablet prepared by a kind of preparation method of the tablet containing aspirin and clopidogrel of the present invention can have Pathological condition, angiocarpy and the cerebrovascular system disease that the treatment of effect is induced by platelet aggregation, and to coat of the stomach not damaged, favorably In the clothes for patients use to aspirin intolerance.
Embodiment
Herein below is to combine specific preferred embodiment further description made for the present invention, it is impossible to is assert The specific implementation of the present invention is confined to these explanations.
A kind of preparation method containing aspirin and clopidogrel, comprises the following steps：
S1. aspirin layer inner core is prepared；
S2. aspirin layer inner core is coated, and then obtains enteric layer；
S3. enteric layer is coated, and then obtains clopidogrel or its medicinal salt deposit；
S4. clopidogrel or its medicinal salt deposit are coated, and then obtain layer soluble in the stomach, and be pressed into containing aspirin and chlorine pyrrole The tablet of Gray.
The aspirin layer inner core includes acetylsalicylic acid or its pharmaceutical salts.
The layer soluble in the stomach includes at least one stomach tolerance polymer and the weight at least 15% of polymer is resistant to relative to stomach Sodium bicarbonate.
The enteric layer includes hydroxypropyl ethyl cellulose and POLYPROPYLENE GLYCOL.
For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, Some simple deduction or replace can also be made, should all be considered as belonging to protection scope of the present invention.

Claims (4)

1. a kind of preparation method containing aspirin and clopidogrel, it is characterised in that comprise the following steps：
S1. aspirin layer inner core is prepared；
S2. aspirin layer inner core is coated, and then obtains enteric layer；
S3. enteric layer is coated, and then obtains clopidogrel or its medicinal salt deposit；
S4. clopidogrel or its medicinal salt deposit are coated, and then obtain layer soluble in the stomach, and be pressed into containing aspirin and chlorine pyrrole The tablet of Gray.
A kind of 2. preparation method containing aspirin and clopidogrel according to claim 1, it is characterised in that the Ah Si Woods layer inner core includes acetylsalicylic acid or its pharmaceutical salts.
3. a kind of preparation method containing aspirin and clopidogrel according to claim 1, it is characterised in that described soluble in the stomach Layer includes at least one stomach tolerance polymer and the sodium bicarbonate of the weight at least 15% of polymer is resistant to relative to stomach.
A kind of 4. preparation method containing aspirin and clopidogrel according to claim 1, it is characterised in that the enteric Layer includes hydroxypropyl ethyl cellulose and POLYPROPYLENE GLYCOL.
CN201710995638.7A 2017-10-23 2017-10-23 A kind of preparation method containing aspirin and clopidogrel Withdrawn CN107693524A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710995638.7A CN107693524A (en) 2017-10-23 2017-10-23 A kind of preparation method containing aspirin and clopidogrel

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710995638.7A CN107693524A (en) 2017-10-23 2017-10-23 A kind of preparation method containing aspirin and clopidogrel

Publications (1)

Publication Number Publication Date
CN107693524A true CN107693524A (en) 2018-02-16

Family

ID=61181469

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710995638.7A Withdrawn CN107693524A (en) 2017-10-23 2017-10-23 A kind of preparation method containing aspirin and clopidogrel

Country Status (1)

Country Link
CN (1) CN107693524A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109288805A (en) * 2018-11-21 2019-02-01 北京汇诚瑞祥医药技术有限公司 A kind of compound aspirin bisulfate clopidogrel clad sheet and preparation method
CN115212180A (en) * 2022-09-03 2022-10-21 深圳市信宜特科技有限公司 Compound preparation of aspirin and clopidogrel hydrogen sulfate and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1993112A (en) * 2004-07-29 2007-07-04 赛诺菲-安万特 Pharmaceutical multilayer tablet for controlled release of active ingredients with highly pH-dependent solubility
CN103906506A (en) * 2011-09-14 2014-07-02 波曾公司 Controlled dosing of clopidogrel with gastric acid inhibition therapies
CN103957895A (en) * 2011-11-02 2014-07-30 韩国联合制药株式会社 Complex agent containing clopidogrel and aspirin
CN105407877A (en) * 2013-08-02 2016-03-16 赛诺菲 Pharmaceutical tablet comprising acetylsalicylic acid and clopidogrel
WO2017037741A1 (en) * 2015-09-02 2017-03-09 Sun Pharmaceutical Industries Ltd Compact solid dosage form of aspirin and clopidogrel
WO2017160101A1 (en) * 2016-03-16 2017-09-21 한국유나이티드제약 주식회사 Composite preparation containing clopidogrel and aspirin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1993112A (en) * 2004-07-29 2007-07-04 赛诺菲-安万特 Pharmaceutical multilayer tablet for controlled release of active ingredients with highly pH-dependent solubility
CN103906506A (en) * 2011-09-14 2014-07-02 波曾公司 Controlled dosing of clopidogrel with gastric acid inhibition therapies
CN103957895A (en) * 2011-11-02 2014-07-30 韩国联合制药株式会社 Complex agent containing clopidogrel and aspirin
CN105407877A (en) * 2013-08-02 2016-03-16 赛诺菲 Pharmaceutical tablet comprising acetylsalicylic acid and clopidogrel
WO2017037741A1 (en) * 2015-09-02 2017-03-09 Sun Pharmaceutical Industries Ltd Compact solid dosage form of aspirin and clopidogrel
WO2017160101A1 (en) * 2016-03-16 2017-09-21 한국유나이티드제약 주식회사 Composite preparation containing clopidogrel and aspirin

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109288805A (en) * 2018-11-21 2019-02-01 北京汇诚瑞祥医药技术有限公司 A kind of compound aspirin bisulfate clopidogrel clad sheet and preparation method
CN109288805B (en) * 2018-11-21 2019-05-31 北京汇诚瑞祥医药技术有限公司 A kind of compound aspirin bisulfate clopidogrel clad sheet and preparation method
CN115212180A (en) * 2022-09-03 2022-10-21 深圳市信宜特科技有限公司 Compound preparation of aspirin and clopidogrel hydrogen sulfate and preparation method thereof
CN115212180B (en) * 2022-09-03 2024-05-10 深圳市信宜特科技有限公司 Compound preparation of aspirin and clopidogrel bisulfate and preparation method thereof

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Application publication date: 20180216

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