CN107693361B - Preparation facilities of high-efficient slowly-releasing nano-drug - Google Patents
Preparation facilities of high-efficient slowly-releasing nano-drug Download PDFInfo
- Publication number
- CN107693361B CN107693361B CN201710822990.0A CN201710822990A CN107693361B CN 107693361 B CN107693361 B CN 107693361B CN 201710822990 A CN201710822990 A CN 201710822990A CN 107693361 B CN107693361 B CN 107693361B
- Authority
- CN
- China
- Prior art keywords
- slow
- layer material
- medicament
- release
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 178
- 229940079593 drug Drugs 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 102
- 238000003475 lamination Methods 0.000 claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 230000006641 stabilisation Effects 0.000 claims abstract description 3
- 238000011105 stabilization Methods 0.000 claims abstract description 3
- 239000002245 particle Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 13
- 238000005520 cutting process Methods 0.000 claims description 12
- 238000001125 extrusion Methods 0.000 claims description 11
- 238000007789 sealing Methods 0.000 claims description 11
- 239000006187 pill Substances 0.000 claims description 10
- 238000007493 shaping process Methods 0.000 claims description 7
- 238000000465 moulding Methods 0.000 claims description 4
- 238000010924 continuous production Methods 0.000 abstract description 2
- 238000000576 coating method Methods 0.000 description 24
- 239000011248 coating agent Substances 0.000 description 22
- 238000000034 method Methods 0.000 description 14
- 239000012530 fluid Substances 0.000 description 12
- 238000012545 processing Methods 0.000 description 11
- 238000013268 sustained release Methods 0.000 description 10
- 239000012730 sustained-release form Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 6
- 239000008188 pellet Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000009434 installation Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000005243 fluidization Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J2200/00—General characteristics or adaptations
- A61J2200/20—Extrusion means, e.g. for producing pharmaceutical forms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation device of high-efficiency slow-release nano-drugs, which belongs to the field of medical equipment and comprises a slow-release layer material conveying device, a drug layer material conveying device, a diversion head, a confluence device, a reverse torsion lamination device and a drug post-treatment device, wherein materials are stably conveyed to the diversion head connected with the front end by the slow-release layer material conveying device and the drug layer material conveying device, initial sheets subjected to confluence, rectification and further pressure and flow stabilization are conveyed into the reverse torsion lamination device by the confluence device, multilayer slow-release nano-drug sheets with uniform thickness are extruded by the reverse torsion lamination device, and the drug sheets are subjected to post-treatment device to obtain drugs with required specifications and shapes. The invention changes the existing preparation process of the slow-release nano-drug, changes intermittent production into continuous production, and greatly improves the production efficiency. The reverse torsion laminator can continuously extrude multiple layers of uniform slow release medicaments, and the medicaments have the characteristic of gradually slow release, thereby providing choices for enriching the functions of slow release medicaments.
Description
Technical Field
The invention relates to a preparation device of a high-efficiency slow-release nano drug, and belongs to the field of medical equipment.
Background
The research and development of slow-release drugs has become an important direction for the development of the pharmaceutical industry at home and abroad. The basic principle of slow release is that the medicine is wrapped in the slow release layer by a proper method, and the medicine is released after the slow release layer is dissolved, thereby achieving the purposes of delaying the release, absorption, distribution, metabolism and excretion processes of the medicine in the body and prolonging the medicine effect.
The slow release layer of the slow release medicine is also called coating, and the preparation device of the coating is continuously innovated, and is mainly provided with a coating pot, a high-efficiency horizontal coating machine, a centrifugal granulating coating machine and the like. The centrifugal granulating and coating machine is a coating device with more use and better effect at present, and the basic principle is that the drug-containing pellets are rotated in a pan by utilizing centrifugal force to form a certain particle flow, atomized coating liquid is uniformly sprayed on the surfaces of a mother core or pellets to form a coating film, and a layer of continuous and compact coating film is formed on the surfaces of the pellets after the solvents such as water and the like in the coating film are evaporated. Because the particles move strongly, the device is not suitable for coating fragile and easily-worn particles and weak particles, the drying capacity is relatively poor, the coating time is long, and two steps of preparing a mother core and coating medicine powder, a diluent, an adhesive and the like on the mother core are needed before coating, so that the process is complex, and the production efficiency is low. In addition to the drawbacks of the centrifugal pellet coater described above, other types of coating equipment suffer from various drawbacks, such as: the coating equipment adopting the fluidization method makes particles move by virtue of air flow, so that the particles move slowly, large particles move difficultly, and small particle coatings are easy to adhere; the equipment adopting the dry pressing coating method directly wraps the coating material outside the medicine through a certain pressure, so that the drying time can be shortened by avoiding moisture, but each station can only process one pill at a time during processing, so that the efficiency is lower, the thickness of the coating and the like are difficult to ensure, and the requirement on the precision of a machine is very high.
Disclosure of Invention
Aiming at the defects of the existing equipment, the invention aims to provide a preparation device of the layer-by-layer slow-release nano-drug, which has the advantages of high efficiency, simple preparation, good molding quality and uniform coating.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: the utility model provides a preparation facilities of high-efficient slowly-releasing nano-drug, mainly include slowly-releasing layer material conveyor, medicine layer material conveyor, the water conservancy diversion aircraft nose, the collector, reverse twists reverse stromatolite ware and medicine aftertreatment device, slowly-releasing layer material conveyor's export and medicine layer material conveyor's export are connected with the water conservancy diversion aircraft nose respectively, slowly-releasing layer material conveyor is used for slowly-releasing layer's measurement to carry, medicine layer material conveyor is used for the measurement of medicine layer to carry, slowly-releasing layer material conveyor, medicine layer material conveyor can be the extruder, slowly-releasing layer material conveyor, medicine layer material conveyor can also be the device that has storage box and delivery pump. The slow release layer material and the drug layer material are generally prepared into a viscous state, have certain fluidity and can flow in a subsequent reverse torsion laminator. The material is stably conveyed to a diversion machine head connected with the front end by a slow-release layer material conveying device and a medicine layer material conveying device, the diversion machine head is respectively conveyed into a confluence device, the slow-release layer material and the medicine layer material form two initial sheets with uniform thickness by the confluence device, the initial sheets after confluence, rectification and further pressure and flow stabilization by the confluence device are conveyed into a reverse torsion laminator, the multilayer slow-release nano medicine sheets with uniform thickness are extruded by the reverse torsion laminator, and finally the medicine sheets are subjected to post-treatment device to obtain medicines with required specification and appearance and are packaged. The diversion machine head, the confluence device, the reverse torsion lamination device and the drug post-treatment device are arranged in sequence.
The extruder for the slow-release layer material conveying device and the medicine layer material conveying device mainly comprises a power system and a conveying system. The conveying system comprises a screw, a machine barrel bushing, a hopper and a screw tail sealing device, wherein the machine barrel bushing is fixedly arranged in the machine barrel, the screw rotates in the machine barrel bushing, materials entering the conveying device from the hopper are conveyed forwards, and the screw tail sealing device prevents the materials from leaking.
The preparation device of the high-efficiency slow-release nano-drug can also connect the slow-release layer material conveying device and the screw rods of the drug layer material conveying device in series, and a power system is used for driving the two screw rods to work simultaneously. The slow-release layer material conveying device and the medicine layer material conveying device are oppositely arranged, the axes of the screw rods are coincident, the screw rods respectively extend out of the machine head, the two screw rods are connected by means of a shaft, the sealing device is arranged at the machine head to prevent the slow-release layer material and the medicine layer material from leaking, and the diversion flow channels of the slow-release layer material and the medicine layer material are at a certain angle with the axes of the screw rods.
The screw and the barrel bushing of the extruder used by the preparation device of the high-efficiency slow-release nano-drug can be provided with screw structures which have the same shape and geometric dimension but opposite screwing directions. The total axial thrust of the screw threads and the barrel bushing threads on the liquid creates a delivery pressure on the liquid, thereby pushing the material to move forward steadily. The barrel may be formed as a segmented barrel for ease of processing, installation and cost. The barrel bushing can be made into a sectional type barrel bushing, so that the sectional type barrel bushing is matched with the sectional type barrel, the processing and the installation are convenient, and the cost is reduced.
The cross sections of the screw rod of the extruder and the threads formed on the barrel bushing can be triangular, trapezoidal, circular and the like, different cross section shapes are suitable for conveying different materials, circular cross section threads can be adopted when the flow is required to be large, and triangular cross section threads can be adopted when the pressure is required to be high; the screw angle of the screw rod meets the processing technology requirement, the conveying capacity of the screw thread to liquid is lower when the screw angle is smaller, and when the screw angle is increased to a certain degree (about 75 degrees), the conveying capacity of the screw thread to liquid is not increased any more, so the screw angle is generally between 70 degrees and 80 degrees; the depth of the screw groove of the screw rod is in accordance with the requirements of the processing technology, the shallower the groove, the stronger the hydrodynamic pressure generated when the screw rod rotates, the higher the conveying pressure, the smaller the flow, and the groove depth is generally between 1 and 4 millimeters; the gap between the major diameter of the screw and the minor diameter of the barrel bushing should meet the processing requirements, and when the groove depth is constant, the larger the gap, the more obvious the reflux effect between the liquid in the screw grooves of the screw and the barrel bushing, the smaller the conveying pressure, and the gap between the major diameter of the screw and the minor diameter of the barrel bushing should be generally between 0.2 and 1 millimeter.
The device for preparing the high-efficiency slow-release nano-drug can be provided with one or more reverse torsion laminators, and the output-input layer number ratio of a single reverse torsion laminators can be multiple. The reverse twist laminator utilizes its twist flow path design to uniformly split the multilayer fluid entering from the inlet into multiple strands, each split multilayer fluid is completely consistent with the previous one, but has a narrow width, and then is conveyed through the twist flow path, the twist flow path comprises forward twist and/or reverse twist, the multilayer fluid is overlapped to form a multilayer sheet with uniform layer thickness, and then the multilayer sheet is output, wherein the relative sequence of the layers overlapped by the forward twist fluid and the reverse twist fluid is reciprocal, such as: the input fluid of the reverse torsion laminator is n types, namely a 1、a2、a3……an-1、an respectively, the ratio of the output layer to the input layer of the reverse torsion laminator is m, the front m/2 is forward torsion, the rear m/2 is reverse torsion, the total output layer number is n multiplied by m layers, and the sequence of the layers is as follows: the first n×m/2 layers are sequentially m/2 cycles of a 1 to a n, and the later n×m/2 layers are sequentially m/2 cycles of a n to a 1. By utilizing the characteristics, the sustained release agent and the medicament can be respectively input into the reverse torsion laminator through the conveying device and extruded by the reverse torsion laminator to obtain the multilayer uniform medicament sheet with the sustained release layer-medicament-sustained release layer- … … -medicament-sustained release layer outside.
The main function of the post-treatment device is to shape and solidify the sheet of medicament extruded from the reverse twist laminator into a finished product. The shaping solidification device comprises a medicament sheet cutting device and a granulating device, wherein a medicament sheet cutting device is firstly arranged at the outlet of the reverse torsion lamination device, the medicament sheet cutting device cuts the medicament sheet into a plurality of medicament strips according to the particle size requirement for manufacturing pills, the medicament strips are further cut into medicament particles with required sizes through the granulating device, a small amount of medicament is exposed on the outer layers of the medicament particles, and the medicament layers and the slow release layers are very thin due to the fact that the medicament and the slow release layers are alternately arranged, the medicament is still slowly released in the use process, and the effect is better under the condition that the size of the medicament particles is small; or the shaping and curing device comprises a medicament sheet cutting device and a granulating device, the medicament strip is granulated, and then the pill with the finished product shape is prepared through an extrusion die and a medicament shaping die, and the surface of the pill is a slow-release layer.
The beneficial effects of the invention are as follows: the novel screw-barrel bushing thread structure of the conveying device has the characteristics of small flow and high conveying pressure, so that the conveying flow and pressure are stable, the pulsation is small, and the controlled release of the slow release medicine dosage and the slow release time is more accurate. Compared with the conventional conveying equipment at present, the conveying equipment has the advantages that the structure is simple, the processing and manufacturing difficulty is greatly reduced, and the used parts are reduced, so that the cost is low. The device thoroughly changes the existing preparation process of the slow-release nano-drug, changes intermittent production into continuous production, and greatly improves the production efficiency. The reverse torsion laminator can continuously extrude multiple layers of uniform slow release medicaments, and the medicaments have the characteristic of gradually slow release, so that more functions of enriching the slow release medicaments are provided. Meanwhile, the device also overcomes a plurality of difficulties in traditional preparation, such as: the coating is not suitable for coating of easily worn particles and fragile particles, large particles are difficult to move, and small particles are easy to adhere. Is a low-cost, high-efficiency and high-quality preparation device for slow-release nano-drugs.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a device for preparing a highly efficient sustained-release nano-drug according to the present invention;
FIG. 2 is a schematic diagram of a single power system driving two delivery devices of a device for preparing highly efficient sustained release nano-drug according to the present invention;
FIG. 3 is a schematic diagram of the flow channel principle of a collector and the flow channel principle of a quadruple reverse torsion laminator and the state of inlet and outlet materials of the preparation device of the high-efficiency slow-release nano-drug;
FIG. 4 is a schematic diagram of the flow channel principle of a confluence device and the flow channel principle of an eight-fold reverse torsion laminator and the state of inlet and outlet materials of the preparation device of the high-efficiency slow-release nano-drug;
FIG. 5 is a schematic cross-sectional view of an extrusion-compression molding process and molded pellet of a device for preparing highly effective sustained release nano-drug according to the present invention;
In the figure: 1-slow release layer material conveying device, 2-medicine layer material conveying device, 3-diversion machine head, 4-confluence device, 5-reverse torsion lamination device, 5-1-four-layer torsion lamination device, 5-2-eight-layer torsion lamination device, 6-medicine post-treatment device, 7-screw, 8-machine barrel, 9-machine barrel bushing, 10-hopper, 11-screw tail sealing device, 12-power system, 13-sealing device, 14-diversion runner, 15-1-forward torsion runner, 15-2-forward torsion runner, 15-3-reverse torsion runner, 15-4-reverse torsion runner, 16-slow release layer material, 17-medicine layer material, 18-1-eight-layer medicine sheet, 18-2-sixteen-layer medicine sheet, 19-double-layer material, 20-extrusion die, 21-medicine forming die and 22-pill.
Detailed Description
The invention relates to a preparation device of a high-efficiency slow-release nano drug, which is shown in figure 1, and mainly comprises a slow-release layer material conveying device 1, a drug layer material conveying device 2, a diversion machine head 3, a confluence device 4, a reverse torsion lamination device 5 and a drug post-treatment device 6, wherein the slow-release layer material conveying device 1 is used for metering and conveying a slow-release layer material 16, the drug layer material conveying device 2 is used for metering and conveying a drug layer material 17, the slow-release layer material conveying device 1 and the drug layer material conveying device 2 can be extruders, and the slow-release layer material conveying device 1 and the drug layer material conveying device 2 can also be devices with storage boxes and conveying pumps. The slow release layer material 16 and the drug layer material 17 are generally formulated to be viscous and have a certain fluidity so as to flow in the subsequent reverse twist laminator 5. The materials are stably conveyed to a diversion machine head 3 connected with the front end by a slow-release layer material conveying device 1 and a medicine layer material conveying device 2, are respectively conveyed into a confluence device 4 by the diversion machine head 3, are converged and rectified by the confluence device 4, are conveyed into a reverse torsion laminator 5 after further stabilizing pressure and flow, are extruded into multi-layer slow-release nano medicine sheets with uniform thickness by the reverse torsion laminator 5, and finally are subjected to medicine preparation with required specification and appearance by a medicine post-treatment device 6 and are packaged.
The extruder used by the slow-release layer material conveying device 1 and the medicine layer material conveying device 2 mainly comprises a power system 12 and a conveying system. The conveying system comprises a screw rod 7, a machine barrel 8, a machine barrel bushing 9, a hopper 10 and a screw rod tail sealing device 11, wherein the machine barrel bushing 9 is fixedly arranged in the machine barrel 8, the screw rod 7 rotates in the machine barrel bushing 9, materials entering the conveying device from the hopper 10 are conveyed forwards, and the screw rod tail sealing device 11 prevents the materials from leaking.
The preparation device of the high-efficiency slow-release nano-drug can also connect the screws of the slow-release layer material conveying device 1 and the drug layer material conveying device 2 in series, and drive the two screws to work simultaneously by using a power system. As shown in fig. 2, the slow-release layer material conveying device 1 and the medicine layer material conveying device 2 are placed relatively, the axes of the screw rods are coincident, the screw rods 7 respectively extend out of the machine head, the two screw rods are connected by means of one shaft, the sealing device 13 is installed at the machine head to prevent the slow-release layer material 16 and the medicine layer material 17 from leaking, the flow guide channels 14 of the slow-release layer material 16 and the medicine layer material 17 form a certain angle with the axes of the screw rods 7, and the conveying device uses proper parameters to realize proper flow, flow velocity and the like of the two materials, so that the process requirements are met.
The screw rod 7 and the cylinder liner 9 of the extruder used by the preparation device of the high-efficiency slow-release nano-drug can be provided with screw thread structures which have the same shape and geometric dimension but opposite rotation directions. The total axial thrust of the screw 7 threads and the barrel bushing 9 threads against the liquid creates a delivery pressure against the liquid, pushing the material forward steadily. Barrel 8 may be formed as a segmented barrel for ease of processing, installation, and cost. The barrel liner 9 can be made into a sectional barrel liner 9, so that the sectional barrel liner 9 is matched with the sectional barrel, and is convenient to process and install and low in cost.
The cross sections of the threads formed on the screw rod 7 and the cylinder liner 9 of the extruder can be triangular, trapezoidal, circular and the like, and different cross section shapes are suitable for conveying different materials, and circular cross section threads can be adopted when the flow is required to be large, and triangular cross section threads can be adopted when the pressure is required to be high; the screw angle of the screw 7 meets the processing technology requirement, the conveying capacity of the screw thread to liquid is lower when the screw angle is smaller, and when the screw angle is increased to a certain degree (about 75 degrees), the conveying capacity of the screw thread to liquid is not increased any more, so the screw angle is generally between 70 degrees and 80 degrees; the depth of the screw groove of the screw rod 7 is in accordance with the requirements of the processing technology, the shallower the groove, the stronger the hydrodynamic pressure generated when the screw rod 7 rotates, the higher the conveying pressure, the smaller the flow, and the groove depth is generally between 1 and 4 millimeters; the gap between the major diameter of the screw 7 and the minor diameter of the barrel bushing 9 should meet the processing requirements, and when the groove depth is constant, the larger the gap, the more obvious the reflux effect between the liquid in the screw 7 and the screw groove of the barrel bushing 9 is, the smaller the pressure of the conveying is, and the gap between the major diameter of the screw 7 and the minor diameter of the barrel bushing 9 should be generally between 0.2 and 1 millimeter.
The reverse torsion laminator 5 used by the preparation device of the high-efficiency slow-release nano-drug can be one or more, a plurality of reverse torsion laminators 5 are in series connection, and the ratio of the output layer to the input layer of each reverse torsion laminators 5 can be multiple. The reverse twist laminator 5 uniformly splits the multi-layer fluid entering from the combiner 4 into a plurality of strands by using its twist flow path design, each split multi-layer fluid is completely identical to the previous one, but has a narrow width, and then is conveyed through the twist flow path, the twist flow path comprises forward twist and/or reverse twist, the multi-layer fluid is overlapped to form a multi-layer medicament sheet with uniform layer thickness, and then the multi-layer medicament sheet is output, wherein the relative sequence of the layers overlapped by the forward twist fluid and the reverse twist fluid is reciprocal. The ratio of the output layer to the input layer of the four-layer reverse twisting laminator 5-1 is 4, as shown in fig. 3, the inlet of the four-layer reverse twisting laminator 5-1 is connected with the confluence device 5, the slow-release layer material 16 and the medicine layer material 17 are converged and are converged into a double-layer material 19 through the confluence device 5, the double-layer material 19 enters from the inlet of the four-layer reverse twisting laminator 5-1 and is evenly split into four strands, the upper two strands of materials flow through the forward twisting runner 15-1 and the forward twisting runner 15-2, the lower two strands of materials flow through the reverse twisting runner 15-3 and the reverse twisting runner 15-4, and four strands of fluid are overlapped at the outlet to form eight layers of medicine sheets 18-1 with even layer thickness and then output. The eight layers of the medicament sheet 18-1 are in turn: the drug comprises a sustained release layer, a drug layer, a sustained release layer, a drug layer and a sustained release layer; in order to improve the efficiency, eight layers of reverse twisting laminators 6-2 can be selected, as shown in fig. 4, the ratio of the output layer to the input layer is 8, four layers above the eight layers of reverse twisting laminators 5-2 are forward twisting flow passages, four layers below the eight layers of reverse twisting flow passages, sixteen layers of medicament sheets 18-2 are extruded through a process similar to that of the four layers of twisting laminators 5-1, and each layer of sixteen layers of medicament sheets 18-2 is formed by sequentially: a slow release layer, a medicament layer, a slow release layer, a medicament layer the drug comprises a drug layer, a slow release layer, a drug layer and a slow release layer.
The main function of the drug post-treatment apparatus of the present invention is to shape and cure the sheet of drug extruded from the reverse twist laminator 5 into a finished drug product. The forming and curing device comprises a medicament sheet cutting device and a granulating device, wherein the medicament sheet cutting device is firstly arranged at the outlet of the reverse torsion laminator 5, the medicament sheet cutting device cuts the medicament sheet into a plurality of medicament strips according to the particle size requirement for manufacturing pills, the medicament strips are further cut into medicament particles with required sizes through the granulating device, a small amount of medicament is exposed on the outer layers of the medicament particles, and the medicament layers and the slow release layers are very thin due to the fact that the medicament and the slow release layers are alternately arranged, the medicament is still slowly released in the use process, and the effect is better under the condition that the size of the medicament particles is small; or the shaping solidification device comprises a medicament sheet cutting device and a granulating device, after granulating the medicament strips, as shown in fig. 5, the medicament is preformed by using an extrusion die 20, the extrusion die 20 is funnel-shaped, two ends of the medicament are big and small, the extrusion die 20 is divided into a left part and a right part, the multi-layer medicament cube particles are preformed into a funnel shape by extrusion, the preformed multi-layer medicament cube particles are molded into pills 22 by using a medicament molding die 21, the pills 22 after the press molding comprise four medicament layers, and the four medicament layers are uniformly wrapped by the four slow release layers respectively.
The above description is of the specific equipment and process of the present invention, and is described with reference to the drawings. The invention is not limited to the specific apparatus and processes described above, any modifications or substitutions to the related apparatus based on the above description, and any local adjustments to the related process based on the above description are within the spirit and scope of the invention.
Claims (3)
1. A preparation device of a high-efficiency slow-release nano drug is characterized in that: the device comprises a slow-release layer material conveying device, a medicine layer material conveying device, a diversion machine head, a confluence device, a reverse torsion lamination device and a medicine post-treatment device, wherein the slow-release layer material conveying device is used for metering and conveying a slow-release layer, the medicine layer material conveying device is used for metering and conveying a medicine layer, and the slow-release layer material and the medicine layer material are prepared into a viscous state and have fluidity; the material is stably conveyed to a diversion head connected with the front end by a slow-release layer material conveying device and a medicine layer material conveying device, the diversion head is respectively conveyed to a confluence device, the slow-release layer material and the medicine layer material form two initial sheets with uniform thickness by the confluence device, the initial sheets after confluence, rectification and further pressure and flow stabilization are conveyed to a reverse torsion lamination device, the multilayer slow-release nano medicine sheets with uniform thickness are extruded by the reverse torsion lamination device, the medicine sheets are finally subjected to post-treatment device to obtain and package medicines with required specification and appearance, the diversion head, the confluence device, the reverse torsion lamination device and the medicine post-treatment device are sequentially arranged, and the medicine post-treatment device enables the medicine sheets extruded from the reverse torsion lamination device to be molded and solidified into medicine finished products; the shaping solidifying device for shaping solidifying comprises a medicament sheet cutting device and a granulating device, wherein a medicament sheet cutting device is firstly arranged at the outlet of the reverse torsion lamination device, the medicament sheet cutting device cuts the medicament sheet into a plurality of medicament strips according to the particle size requirement for manufacturing pills, and the medicament strips are further cut into medicament particles with the required size through the granulating device; or the shaping and solidifying device comprises a medicament sheet cutting device, a granulating device and an extrusion die, after granulating the medicament strips, the medicament is preformed by using the extrusion die, the extrusion die is funnel-shaped, two ends of the medicament are big and middle of the medicament are small, the extrusion die is divided into a left part and a right part, the multilayer medicament cube particles are preformed into a funnel shape by extrusion, and then the preformed multilayer medicament cube particles are molded into pills by using the medicament molding die; the slow-release layer material conveying device and the medicine layer material conveying device are extruders, each extruder comprises a power system and a conveying system, each conveying system comprises a screw, a machine barrel bushing, a hopper and a screw tail sealing device, the machine barrel bushing is fixedly arranged in the machine barrel, the screw rotates in the machine barrel bushing to convey materials entering the conveying device from the hopper forwards, the screw tail sealing device prevents the materials from leaking, and the cross sections of threads formed on the screw and the machine barrel bushing of the extruder are triangular, trapezoidal or circular; the helix angle is between 70 and 80 degrees; the depth of the screw groove of the screw rod is between 1 and 4 millimeters; the clearance between the major diameter of the screw and the minor diameter of the barrel bushing is between 0.2 and 1 mm.
2. The preparation device of the high-efficiency slow-release nano-drug according to claim 1, which is characterized in that: the screw rods of the slow-release layer material conveying device and the medicine layer material conveying device are connected in series, a power system is used for driving the two screw rods to work simultaneously, the slow-release layer material conveying device and the medicine layer material conveying device are placed oppositely, the axis lines of the screw rods coincide, the screw rods extend out of the machine head respectively, the two screw rods are connected by means of a shaft, the sealing device is arranged at the machine head, and the diversion flow channels of the slow-release layer material and the medicine layer material form a certain angle with the axis line of the screw rod.
3. The preparation device of the high-efficiency slow-release nano-drug according to claim 1, which is characterized in that: screw rods and cylinder bushings of the extruder are provided with screw structures which are identical in shape and geometric dimension but opposite in rotation direction, and the total axial thrust of the screw rods and the screw rods of the cylinder bushings to liquid forms the conveying pressure to the liquid, so that the materials are pushed to stably move forwards; the barrel is made as a segmented barrel or the barrel liner is made as a segmented barrel liner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710822990.0A CN107693361B (en) | 2017-09-13 | 2017-09-13 | Preparation facilities of high-efficient slowly-releasing nano-drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710822990.0A CN107693361B (en) | 2017-09-13 | 2017-09-13 | Preparation facilities of high-efficient slowly-releasing nano-drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107693361A CN107693361A (en) | 2018-02-16 |
| CN107693361B true CN107693361B (en) | 2024-04-26 |
Family
ID=61172575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710822990.0A Active CN107693361B (en) | 2017-09-13 | 2017-09-13 | Preparation facilities of high-efficient slowly-releasing nano-drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107693361B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114224735A (en) * | 2021-12-07 | 2022-03-25 | 徐斌 | Uniform slow-release capsule |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1938004A (en) * | 2004-03-30 | 2007-03-28 | 欧洲凯尔特公司 | Tamper resistant dosage form comprising an adsorbent and an adverse agent |
| CN101862230A (en) * | 2009-04-17 | 2010-10-20 | 华中科技大学同济医学院附属协和医院 | Controlled-release multilayer drug-loaded artificial bone and preparation method thereof |
| CN102615906A (en) * | 2012-03-15 | 2012-08-01 | 北京化工大学 | Antistatic plate and molding method thereof |
| JP2012246252A (en) * | 2011-05-27 | 2012-12-13 | Bayer Yakuhin Ltd | Modified-release type particle pharmaceutical composition for oral administration, method for producing the same, and orally disintegrating tablet including the composition |
| WO2015158282A1 (en) * | 2014-04-17 | 2015-10-22 | 奥卓海（上海）机械有限公司 | Single screw extruder for extrusion of pure materials of ultra-high-molecular-weight polyethylene |
| CN106344497A (en) * | 2016-09-05 | 2017-01-25 | 四川大学 | Preparation method of macromolecular multi-layered hydrogel drug sustained-release material |
| CN207871152U (en) * | 2017-09-13 | 2018-09-18 | 北京化工大学 | A kind of preparation facilities of high-efficiency sustained-release Nano medication |
-
2017
- 2017-09-13 CN CN201710822990.0A patent/CN107693361B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1938004A (en) * | 2004-03-30 | 2007-03-28 | 欧洲凯尔特公司 | Tamper resistant dosage form comprising an adsorbent and an adverse agent |
| CN101862230A (en) * | 2009-04-17 | 2010-10-20 | 华中科技大学同济医学院附属协和医院 | Controlled-release multilayer drug-loaded artificial bone and preparation method thereof |
| JP2012246252A (en) * | 2011-05-27 | 2012-12-13 | Bayer Yakuhin Ltd | Modified-release type particle pharmaceutical composition for oral administration, method for producing the same, and orally disintegrating tablet including the composition |
| CN102615906A (en) * | 2012-03-15 | 2012-08-01 | 北京化工大学 | Antistatic plate and molding method thereof |
| WO2015158282A1 (en) * | 2014-04-17 | 2015-10-22 | 奥卓海（上海）机械有限公司 | Single screw extruder for extrusion of pure materials of ultra-high-molecular-weight polyethylene |
| CN106344497A (en) * | 2016-09-05 | 2017-01-25 | 四川大学 | Preparation method of macromolecular multi-layered hydrogel drug sustained-release material |
| CN207871152U (en) * | 2017-09-13 | 2018-09-18 | 北京化工大学 | A kind of preparation facilities of high-efficiency sustained-release Nano medication |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107693361A (en) | 2018-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2015258536B2 (en) | Plasticizing delivery method and device using eccentric rotor and having pulsed volume deformation | |
| KR20030015383A (en) | Tubular Multilayer Films, Method and Apparatus for Preparing the Same | |
| TW200302191A (en) | Apparatus and method for manufacturing encapsulated products | |
| CN107693361B (en) | Preparation facilities of high-efficient slowly-releasing nano-drug | |
| CN104210080A (en) | Co-extrusion molding device for wood plastic-solid wood composite material | |
| CN110948850B (en) | Feeding device for small-sized metal mold 3D printer | |
| JPS5833092B2 (en) | Oshidashi Souchi | |
| US20120049410A1 (en) | Apparatus and process for making soft gel capsules | |
| CN201587107U (en) | Device for preparing nano laminated composite material | |
| CN102908317A (en) | Macrolide antibiotics enteric-coated pellets and coating solution thereof | |
| CN207871152U (en) | A kind of preparation facilities of high-efficiency sustained-release Nano medication | |
| CN109531952A (en) | A kind of conical parallel dual-screw thin film extruding machine | |
| CN203622907U (en) | Pelletizing equipment for producing full-starch based capsule granule material | |
| CN210062018U (en) | Multi-material gradient forming melt extrusion and granular heterogeneous multi-material extrusion system | |
| DE102006007482B4 (en) | Apparatus and method for producing a tubular enclosure | |
| CN108421497A (en) | The production technology and equipment of drug serialization granulation | |
| CN206048746U (en) | A kind of co-extrusion die head of extrusion with double conduction section bars | |
| CN205075314U (en) | Adhesive tape extrusion device | |
| CN102029717B (en) | Vulcanized rubber processing device and method | |
| CN109772229A (en) | A kind of method of drug serialization granulation | |
| WO2012109999A1 (en) | Processing method and related processing device for binding fluoroplastic to polyethylene terephthalate layer surface | |
| CN2631735Y (en) | Mould for plastic injection machine | |
| CN206614770U (en) | A kind of extruder | |
| CN117679384A (en) | Preparation method of multistage sustained and controlled release preparation | |
| JPH035103A (en) | Manufacture and device for tablet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |