CN107687963A - Confirmatory sample samples the method, apparatus and blood cell analyzer of reliability - Google Patents
Confirmatory sample samples the method, apparatus and blood cell analyzer of reliability Download PDFInfo
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- CN107687963A CN107687963A CN201610634882.6A CN201610634882A CN107687963A CN 107687963 A CN107687963 A CN 107687963A CN 201610634882 A CN201610634882 A CN 201610634882A CN 107687963 A CN107687963 A CN 107687963A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
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Abstract
This application discloses the method, apparatus and blood cell analyzer of a kind of confirmatory sample sampling reliability, methods described includes providing sampling probe, the rear end of the sampling probe is connected with one end of a printing opacity pipeline, the other end of the printing opacity pipeline connects power source, and photoelectric sensing component is provided with the printing opacity pipeline；In the presence of the power source, sample is sucked sampling probe by the sampling probe from its front end, completes to inhale sample operations；In the presence of the power source, by the sample post-tensioning in sampling probe, sample is set at least to be pulled at the photoelectric sensing component set on the printing opacity pipeline；The photoelectric sensing component feeds back detection signal；The signal fed back according to photoelectric sensing component, judge to inhale sample operations it is whether normal, therefore, this application provides a kind of simple to operate, cost it is low judge inhale the whether normal scheme of sample operations.
Description
Technical field
The application is related to a kind of method, apparatus and blood cell analyzer of confirmatory sample sampling reliability.
Background technology
Blood cell analyzer is the instrument that a kind of Human Blood to extraction is analyzed.Ensure analysis result just
Really, it will monitor first and be used to inhale sample in blood cell analyzer and divide the suction sample of sample whether to divide sampling device from filling human body
Normal extraction blood sample in the test tube class container of blood sample (blood sample).The relatively low photoelectric technology monitoring of use cost inhales sample and divides sample to fill
Put whether normal extraction blood sample, mainly have two class schemes at present.
Divide sample valve first, introducing sampling and divide sample valve both sides to be respectively arranged with optocoupler in sampling.Inhaling sample divides sampling device to use
Sampling divides sample valve quantitative sample, sample is divided into some deciles, in this process, by being arranged at a point optocoupler for sample valve both sides
Whether device detects sample to monitor whether sample is normally inhaled sample.This kind of scheme generally only occurs at high-end blood cell
On analyzer, because its cost is very high.In addition, in this scheme, there is stream because sampling probe to sampling divides between sample valve, therefore
The sample for being not used for analysis is also more (from consumption).
Second, it is alternately at regular intervals transmittance section and the appearance of light shielding part that sampling probe, which is made along longitudinal direction, then pass through
Sensitive device receives the light through sampling probe that is sent by luminescent device to confirm liquid measure.This sampling probe is by quartz glass and firmly
The transparent materials such as matter clear glass are formed, and its surface is along longitudinal direction spraying plating aluminium foil etc. at regular intervals.The shortcomings that this scheme is,
Quartz glass, hard transparent glass lamp material are difficult to carry out Precision Machining, it is difficult to meet sampling probe machining accuracy demand.
And the sampling probe of the metal class for machining accuracy demand can be met, because metal material itself is light tight, because
This is difficult to use relatively inexpensive photoelectric technology and directly monitors suction sample reliability.
The content of the invention
To solve the above problems, the application provides a kind of method, apparatus and blood cell of confirmatory sample sampling reliability
Analyzer.
According to the application's in a first aspect, the application provides a kind of method of confirmatory sample sampling reliability, including：
Sampling probe is provided, the rear end of the sampling probe is connected with one end of a printing opacity pipeline, the printing opacity pipeline it is another
End connects power source, and photoelectric sensing component is provided with the printing opacity pipeline；
In the presence of the power source, sample is sucked sampling probe by the sampling probe from its front end, completes to inhale sample behaviour
Make；
In the presence of the power source, by the sample post-tensioning in sampling probe, sample is set at least to be pulled to the light-transmission tube
At the photoelectric sensing component set on road；
The photoelectric sensing component feeds back detection signal；
The signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal.
More preferably, the signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal, including：When anti-
In the curve of the signal of feedback, do not include signal curve corresponding with sample, or when signal curve corresponding with sample has abnormal,
Then judge to inhale sample operations exception.
More preferably, before sampling probe carries out suction sample operations, isolation gas column is established also in sampling probe；
The signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal, including：When in feedback
In the curve of signal, do not include signal curve corresponding with sample, or do not include signal curve corresponding with isolation gas column, or with
When signal curve has abnormal corresponding to sample, then judge to inhale sample operations exception.
More preferably, the printing opacity pipeline is transparent pipeline, and/or, the photoelectric detection component includes an optical transmitting set
With an optical receiver, the optical transmitting set and the optical receiver form light path, at least a portion warp of the printing opacity pipeline
Cross the light path.
More preferably, methods described is additionally included in the presence of the power source, and part sample is preceding pushed away in the past in sampling probe
Needle point discharge is held, to carry out a point sample operations；
The sample post-tensioning by sampling probe, after sample operations are inhaled and before dividing sample operations, or positioned at point
After sample operations, or positioned at dividing during sample operations.
According to the second aspect of the application, the application provides a kind of device of confirmatory sample sampling reliability, including sampling
Pin and power source, in addition to:
Printing opacity pipeline, its one end are connected with the rear end of sampling probe, and the other end is connected with the power source；
Photoelectric sensing component, it is arranged on printing opacity pipeline, after carrying out suction sample operations for sampling probe, sampling probe
In the presence of the power source, the sample in sampling probe is at least pulled at the photoelectric sensing component on printing opacity pipeline backward
When, feed back corresponding detection signal, wherein described be at least pulled to sample at photoelectric sensing component backward, inhaled positioned at sampling probe
After sample and divide before sample, or divide after sampling probe divides sample, or positioned at sampling probe during sample operations；
Judging unit, for the signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal.
More preferably, the judging unit when photoelectric sensing component feedback signal curve in, do not include and sample pair
The signal curve answered, or when signal curve corresponding with sample has abnormal, then judge to inhale sample operations abnormal.
More preferably, judging unit is worked as in the curve of the signal of photoelectric sensing component feedback, is not included corresponding with sample
Signal curve, or do not include with the corresponding signal curve of isolation gas column, or when signal curve corresponding with sample has abnormal, then
Judge to inhale sample operations exception；Wherein, before sampling probe carries out suction sample operations, isolation gas is also established in sampling probe
Post.
More preferably, the printing opacity pipeline is transparent pipeline, and/or, the photoelectric detection component includes an optical transmitting set
With an optical receiver, the optical transmitting set and the optical receiver form light path, at least a portion warp of the printing opacity pipeline
Cross the light path.
More preferably, the photoelectric detection component is arranged at rear end of the printing opacity pipeline close to sampling probe.
According to the third aspect of the application, the application provides a kind of blood cell analyzer, including for inhaling sample and dividing
The suction sample of sample divides sampling device, blood examination device, input unit and display device for input instruction, it is characterised in that
The device inhaled sample and divide sampling device to include the confirmation specimen sample reliability as any one of claim 6 to 10, its
In, input unit acceptance test instruction, the suction sample divides sampling device absorption sample to be supplied to blood test device, blood testing dress
Put detection sample and obtain pattern detection result, the display device shows pattern detection result.
More preferably, when the device of confirmatory sample sampling reliability judges to inhale sample operations exception：
The display device does not show the pattern detection result or shows result not near the pattern detection result
Reliable mark；
And/or
The device of the confirmatory sample sampling reliability sends instructions to suction sample and divides sampling device to draw same sample again, with
Blood test device is supplied to, or, send instructions to suction sample and divide sampling device it is stopped providing sample to blood test device.
The beneficial effect of the application is：
According to the method, apparatus and blood cell analyzer of the confirmation specimen sample reliability of above-mentioned implementation, due to sampling
Pin rear portion is connected with a printing opacity pipeline, and photoelectric sensing component is set on printing opacity pipeline, when judging that inhaling sample operations is
It is no normal, only need to be by the photoelectric sensing component at least post-tensioning of the sample in sampling probe to printing opacity pipeline, you can according to photoelectricity
The signal of sensory package feedback, judge to inhale sample operations it is whether normal, therefore, this application provides it is a kind of it is simple to operate,
Cost it is low judge inhale the whether normal scheme of sample operations；Further, since the application is that sample is pulled into printing opacity pipeline to examine
Survey, therefore may be equally applicable for this kind of lighttight sampling probe of metal.
Brief description of the drawings
Fig. 1 is the schematic flow sheet of the method for the confirmation specimen sample reliability of the embodiment of the application one；
Fig. 2 (a), (b), (c) are respectively to inhale sample in a kind of method of the confirmation specimen sample reliability of embodiment of the application
Normal, abnormal, the abnormal signal curve schematic diagram of this operation, wherein ordinate are signal amplitude, and abscissa is the time；
Fig. 3 is the schematic flow sheet of the method for the confirmation specimen sample reliability of another embodiment of the application；
Fig. 4 (a), (b), (c), (d) are respectively the method for the confirmation specimen sample reliability of the application another kind embodiment
Middle suction sample operations are normal, exception, abnormal, abnormal signal curve schematic diagram, and wherein ordinate is signal amplitude, and abscissa is
Time；
Fig. 5 is the structural representation of the blood cell analyzer of the embodiment of the application one；
Fig. 6 is the structural representation of the device of the confirmation specimen sample reliability of the embodiment of the application one.
Embodiment
Present invention design is, a printing opacity pipeline, printing opacity are connected at the rear portion of the sampling probe of blood analyser
Photoelectric sensing component is provided with pipeline, by by the photoelectric sensing component of at least post-tensioning of the sample in sampling probe to printing opacity pipeline
Place, the signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal.The most frequently used photoelectric sensing component is one
To optocoupler, including optical transmitting set and optical receiver, they are oppositely arranged on printing opacity pipeline both sides, optical transmitting set and light-receiving
Device forms light path, and at least a portion of the printing opacity pipeline passes through the light path.Other being capable of liquid absorbance change in signal piping
Photoelectric sensing part can also be applied.
The application is described in further detail below by embodiment combination accompanying drawing.
Embodiment one
Present embodiment discloses a kind of method of confirmatory sample sampling reliability, and it can be used for the suction sample for judging sampling probe
Whether this operation is normal.To coordinate the method for the present embodiment, the rear end of the sampling probe in the present embodiment and the one of a printing opacity pipeline
End is connected, the other end connection power source of printing opacity pipeline, and photoelectric sensing component is provided with printing opacity pipeline；Wherein power source is to use
In providing absorption sample to sampling probe and discharging the power of sample, the most frequently used power source is syringe.It refer to Fig. 1, this reality
The method for applying the confirmation specimen sample reliability of example specifically includes step S101~S111.
Step S101, in the presence of power source, sampling probe carries out suction sample operations at forward tip.
Step S103, sample is preceding pushed away in the presence of power source, in sampling probe discharges from forward tip, to carry out a point sample
This operation.
Step S105, in the presence of power source, by the sample post-tensioning in sampling probe, sample is made at least to be pulled to above-mentioned
The photoelectric sensing component set on light pipe road is everywhere.In order that the signal of photoelectric sensing component feedback becomes apparent from, in an embodiment
In, printing opacity pipeline can be transparent pipeline.This step S105 can step S101 carried out inhale sample operations after and step
S103 carried out before point sample operations；It can also be carried out during step S103 carries out point sample operations, for example,
The sample of absorption is divided into several pieces by step S103, is drained into respectively in corresponding reaction vessel, is arranged when by certain a sample
Enter to after corresponding reaction vessel, before lower a sample is drained into corresponding reaction vessel, step can be carried out
S105；Step S105 can also be carried out after step S103 has carried out point sample operations.When this step S105 is by sampling probe
Sample post-tensioning operation, when having carried out positioned at step S103 after point sample operations, this have the advantage that to dividing sample to grasp
The influence of work is minimum, even without influence.In one embodiment, photoelectric sensing component is arranged at printing opacity pipeline close to sampling probe
Rear end, the distance that such sample is pulled with regard to relatively reduced, on sample in itself caused by influence it is also small.In one embodiment,
In order to reach more preferable effect, position that can be by sample post-tensioning by photoelectric sensing component.
Step S107, photoelectric sensing component feedback signal.In one embodiment, photoelectric sensing component can entirely inhaled
It is at working condition when sample operations and point sample operations or is pulled open after step S105 is by the sample in sampling probe
During the beginning, just start working., can constant feedback signal during photoelectric sensing component operation.
Step S109, the signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal.It is specific real one
Apply in example, this step S109 includes working as in the curve of the signal of photoelectric sensing component feedback, does not include letter corresponding with sample
Number curve, or when signal curve corresponding with sample has abnormal, then judge to inhale sample operations abnormal, in one embodiment, sentences
After disconnected suction sample operations exception, step S111, alarm are carried out, and further can also be shielded the measurement result of sample
Cover.This step S109 can also include when photoelectric sensing component feedback signal curve in, including it is corresponding with sample just
During normal signal curve, then judge to inhale sample operations it is normal, in one embodiment, judge to inhale sample operations it is normal after, walked
Rapid S113, the normal measurement result for exporting sample.It is to judge to inhale according to the signal of photoelectric sensing component feedback in the present embodiment
Whether sample operations normal, and inventor passes through numerous studies and practice, find it is normal when inhaling sample operations, when sample be pulled to it is logical
When crossing the photoelectric sensing component that light-transmission tube is led, in the curve of the corresponding signal of photoelectric sensing component feedback, what this was pulled
Signal curve corresponding to sample is length with height in a range of curve, as shown in Fig. 2 (a)；When do not include and sample pair
The signal curve answered --- as shown in Fig. 2 (b), or signal curve corresponding with sample is present abnormal (such as the abnormal shake of figure)
When --- as shown in Fig. 2 (c), then it is particularly likely that and inhales sample operations there occurs abnormal, wherein, shown in Fig. 2 (b) is corresponding
Signal curve in do not include the situation of signal curve corresponding to sample, this explanation sampling probe is likely to not be drawn onto sample, Fig. 2
(c) shown in is that signal curve corresponding with sample there is a situation where to shake extremely, and this explanation inhales sample operations and abnormal feelings be present
Condition, such as sampling probe are likely to inspiration air while suction sample.So Fig. 2 (a) situation, can be judged as inhaling sample behaviour
Work is normal, and it is abnormal that Fig. 2 (b) and (c) situation, which can be judged as inhaling sample operations,.
Embodiment two
The present embodiment also discloses that a kind of method of confirmatory sample sampling reliability, is with the difference of embodiment one,
The signal fed back according to photoelectric sensing component, when judging whether suction sample operations are normal, not only allow for signal corresponding to sample
Curvilinear characteristic, it is also contemplated that signal curve feature corresponding to isolation gas column, be specifically described below.
The method of the confirmation specimen sample reliability of the present embodiment, refer to Fig. 3, its specifically include step S200~
S211。
Step S200, in the presence of power source, isolation gas column is established in sampling probe.
Step S201, in the presence of power source, sampling probe carries out suction sample operations at forward tip.
Step S203, sample is preceding pushed away in the presence of power source, in sampling probe discharges from forward tip, to carry out a point sample
This operation.
Step S205, in the presence of power source, by the sample post-tensioning in sampling probe, sample is made at least to be pulled to above-mentioned
At the photoelectric sensing component set on light pipe road.In order that the signal of photoelectric sensing component feedback becomes apparent from, in one embodiment,
Printing opacity pipeline can be transparent pipeline.Similar with embodiment one, this step S205 can carry out inhaling sample behaviour in step S201
After work and step S203 carried out before point sample operations；Can also be during step S203 carries out point sample operations
Carry out；Step S205 can also be carried out after step S203 has carried out point sample operations.When this step S205 is by sampling probe
Sample post-tensioning operation, when having carried out positioned at step S203 after point sample operations, this have the advantage that to dividing sample to grasp
The influence of work is minimum, even without influence.In one embodiment, photoelectric sensing component is arranged at printing opacity pipeline close to sampling probe
Rear end, the distance that such sample is pulled with regard to relatively reduced, on sample in itself caused by influence it is also small.In one embodiment,
In order to reach more preferable effect, position that can be by sample post-tensioning by photoelectric sensing component.
Step S207, photoelectric sensing component feedback signal.In one embodiment, photoelectric sensing component can entirely inhaled
It is at working condition when sample operations and point sample operations or is pulled open after step S205 is by the sample in sampling probe
During the beginning, just start working., can constant feedback signal during photoelectric sensing component operation.
Step S209, the signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal.It is specific real one
Apply in example, this step S207 includes working as in the curve of the signal of photoelectric sensing component feedback, does not include letter corresponding with sample
Number curve, or do not include signal curve corresponding with isolation gas column, or when signal curve corresponding with sample has abnormal, then sentence
Disconnected sample operations of inhaling are abnormal, in one embodiment, judge after inhaling sample operations exception, carry out step S211, alarm, and may be used also
So that further the measurement result of sample to be shielded.This step S209 can also be included when the signal of photoelectric sensing component feedback
Curve in, including when normal signal curve corresponding with sample and signal curve corresponding with isolation gas column, then judge to inhale
Sample operations are normal, in one embodiment, after judging that suction sample operations are normal, carry out step S213, the normal survey for exporting sample
Measure result.It is to judge whether suction sample operations are normal according to the signal of photoelectric sensing component feedback in the present embodiment, inventor
By numerous studies and practice, when finding normal suction sample operations, when sample is pulled to the photoelectric sensing group led by light-transmission tube
During part, in the corresponding signal curve of photoelectric sensing component feedback, signal curve corresponding to this sample being pulled is length
With height in a range of curve, isolate gas column corresponding to signal curve be also length with height in a range of curve,
As shown in Fig. 4 (a)；When not including signal curve corresponding with sample --- as shown in Fig. 4 (b), or do not include with isolating gas column
Corresponding signal curve --- as shown in Fig. 4 (c), or when signal curve corresponding with sample has abnormal --- such as Fig. 4 (d) institutes
Show, be then particularly likely that and inhale sample operations there occurs abnormal, wherein, shown in Fig. 4 (b) is not wrapped in corresponding signal curve
Include the situation of signal curve corresponding with sample, this explanation sampling probe be likely to not be drawn onto sample, shown in Fig. 4 (c) be
Corresponding signal curve does not include the situation of signal curve corresponding with isolation gas column, and this explanation sampling probe is in sample processes are inhaled
The isolation gas column that should be established is not established, sample operations is inhaled and exception be present, shown in Fig. 4 (d) is signal corresponding with sample
There is exception in curve, this explanation inhales sample operations and abnormal conditions be present, such as while sampling probe is likely to inhale sample
Inspiration air.So Fig. 4 (a) situation, it is normal, Fig. 4 (b), (c) and (d) situation that can be judged as inhaling sample operations
It is abnormal that can be judged as inhaling sample operations.
Embodiment three
Present embodiment discloses a kind of blood cell analyzer, as shown in figure 5, it includes being used to inhale sample and divides sample
Inhale sample and divide sampling device 100, blood examination device 300, input unit 500 and display device 700 for input instruction.
Inhale the device that sample divides sampling device 100 to include a kind of confirmatory sample sampling reliability.It refer to Fig. 6, above-mentioned confirmation sample
The device of this sampling reliability includes sampling probe 10, printing opacity pipeline 20, photoelectric detection component 30, power source and judging unit 50.
Power source is that the most frequently used power source is syringe for providing the power drawn sample and discharge sample to sampling probe 10, under
Face might as well carry out description below by taking syringe 40 as an example.
One end of printing opacity pipeline 20 is connected with the rear end of sampling probe 10, and the other end is connected with the syringe of syringe 40.One
In embodiment, printing opacity pipeline 20 is transparent pipeline.
Photoelectric detection component 30 is arranged on printing opacity pipeline 20, after carrying out suction sample operations for sampling probe 10, note
The piston core pin of emitter 40 is pulled back so that the sample in sampling probe 10 to be at least pulled to the Photoelectric Detection on printing opacity pipeline 20 backward
When at component 30, feed back corresponding signal, wherein sample is at least pulled at photoelectric detection component 30 backward, positioned at sampling probe 10
Inhale sample afterwards and divide before sample, or divide sample operations process after sampling probe 10 divides sample, or positioned at sampling probe 10
In.In one embodiment, photoelectric detection component 30 is arranged at rear end of the printing opacity pipeline 20 close to sampling probe, and such sample is drawn
Dynamic distance with regard to relatively reduced, on sample in itself caused by influence it is also small.In one embodiment, in order to reach more preferable effect,
Position that can be by sample post-tensioning by photoelectric detection component 30.
Judging unit 50 is used for the signal fed back according to photoelectric detection component 30, judges whether suction sample operations are normal.
In one embodiment, judging unit 50 is worked as in the curve for the signal that photoelectric detection component 30 is fed back, and does not include letter corresponding with sample
Number curve, or when signal curve corresponding with sample has abnormal, then judge to inhale sample operations abnormal, and specific deterministic process can
Reference implementation example one and Fig. 2, will not be repeated here；Correspondingly, in one embodiment, judging unit 50 is also when photoelectric sensing component
When the signal curve of 30 feedbacks includes normal signal curve corresponding with sample, then judge that suction sample operations are normal.One
In preferred embodiment, it is also contemplated that isolation gas column problem, judging unit 50 are worked as in the curve for the signal that photoelectric detection component 30 is fed back,
Do not include signal curve corresponding with sample, or do not include signal curve corresponding with isolation gas column, or letter corresponding with sample
When number curve has abnormal, then judge to inhale sample operations it is abnormal, wherein, before sampling probe 10 carries out suction sample operations, also exist
Isolation gas column is established in sampling probe 10；Specific deterministic process refers to embodiment two and Fig. 4, will not be repeated here；Accordingly
Ground, in one embodiment, judging unit 50 are including corresponding with sample also when in the curve for the signal that photoelectric sensing component 30 feeds back
Normal signal curve and during with the isolation corresponding signal curve of gas column, then judge to inhale sample operations normal.
Input unit 500 instructs for acceptance test, inhales sample and divides the absorption sample of sampling device 100 to be supplied to blood test device
300, blood test device 300 detects sample and obtains pattern detection result, and display device 700 shows pattern detection result.One
In embodiment, when the judging unit 50 in the device of confirmatory sample sampling reliability judges to inhale sample operations exception, display dress
700 are put not show the pattern detection result or show the insecure mark of result near the pattern detection result.With/
Or, when the judging unit 50 in the device of confirmatory sample sampling reliability judges to inhale sample operations exception, confirmatory sample sampling
The device of reliability sends instructions to suction sample and divides sampling device 100 to draw same sample again, to be supplied to blood test device
300, or, send instructions to suction sample and divide sampling device 100 it is stopped providing sample to blood test device 300.
Below might as well be so that the operation of sample post-tensioning to be located at after a point sample operations terminate, and according to isolation gas column and sample
Exemplified by curve judges whether suction sample operations are normal jointly, illustrate the blood cell analyzer and confirmatory sample sampling of the present embodiment
The course of work of the device of reliability.
The sampling probe 10 of blood cell analyzer is before use, can be through over cleaning, to ensure to clean or eliminate a upper sample
Carrying pollution after this sampling, before this sub-sampling, has dilution, in order to reduce possibility of the dilution to sample in sampling probe 10
Dilution, one section of air is preferably first sucked before sample is drawn, afterwards sampling probe 10 be moved to inhale sample position after, syringe 40
Piston core pin pull back, make sampling probe 10 forward tip aspirate scheduled volume sample, now, between dilution and sample
Air insulated is formed isolating gas column.Then sampling probe 10 is moved to each corresponding point sample position, wherein at each point
During sample position, the piston core pin of syringe 40 pushes away forward, sample in sampling probe 10 is discharged from the forward tip of sampling probe 10.
When having terminated point sample operations, the piston core pin of syringe 40 pulls back, and is pulled the remaining sample in sampling probe 10
In printing opacity pipeline 20, until reaching or by the position where the photoelectric detection component 30 on printing opacity pipeline 20.Photoelectric Detection group
Part 30 can working condition is at when entirely inhaling sample operations and point sample operations or when terminating a point sample
Just started working during this operation.When photoelectric detection component 30 is in running order, feedback signal, judging unit 50 are used for always for meeting
The signal fed back according to photoelectric detection component 30, judge whether suction sample operations are normal.When the letter that photoelectric detection component 30 is fed back
Number curve include with the isolation corresponding normalized curve of gas column and during normalized curve corresponding with sample, as shown in Fig. 4 (a),
Then judge that suction sample operations are normal；When photoelectric detection component 30 feed back signal curve in do not include signal corresponding with sample
Curve, as shown in Fig. 4 (b), then judge to inhale sample operations exception；Do not wrapped when in the curve for the signal that photoelectric detection component 30 is fed back
Signal curve corresponding with isolation gas column is included, as shown in Fig. 4 (c), also judges to inhale sample operations exception；When photoelectric detection component 30
When signal curve corresponding with sample has abnormal in the curve of the signal of feedback, as shown in Fig. 4 (d), also judge to inhale sample behaviour
Make abnormal.
This application discloses the method, apparatus and blood cell analyzer of a kind of confirmatory sample sampling reliability.It can be with
Applied to the suction needle being made up of transparent materials such as quartz glass and hard transparent glass, can also be applied to meet to process
The sampling probe of the metal class of accuracy requirement, in the case where point sample valve need not be sampled, it is connected by one with sampling probe rear end
Printing opacity conduit and be arranged at the supravasal photoelectric detection component of printing opacity, it is possible to judge sampling probe inhale sample operations whether just
Often, scheme mature and reliable, and it is cost-effective.
Above content is to combine the further description that specific embodiment is made to the application, it is impossible to assert this Shen
Specific implementation please is confined to these explanations.For the application person of an ordinary skill in the technical field, do not taking off
On the premise of conceiving from the present application, some simple deduction or replace can also be made.
Claims (12)
- A kind of 1. method of confirmatory sample sampling reliability, it is characterised in that including：Sampling probe is provided, the rear end of the sampling probe is connected with one end of a printing opacity pipeline, and the other end of the printing opacity pipeline connects Power source is connect, photoelectric sensing component is provided with the printing opacity pipeline；In the presence of the power source, sample is sucked sampling probe by the sampling probe from its front end, completes to inhale sample operations；In the presence of the power source, by the sample post-tensioning in sampling probe, sample is set at least to be pulled on the printing opacity pipeline At the photoelectric sensing component of setting；The photoelectric sensing component feedback signal；The signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal.
- 2. the method for confirmatory sample sampling reliability as claimed in claim 1, it is characterised in that anti-according to photoelectric sensing component The signal of feedback, judge whether suction sample operations are normal, including：When in the curve in the signal of feedback, do not include corresponding with sample Signal curve, or when signal curve corresponding with sample has abnormal, then judge to inhale sample operations abnormal.
- 3. the method for confirmatory sample sampling reliability as claimed in claim 1, it is characterised in that：Before sampling probe carries out suction sample operations, isolation gas column is established also in sampling probe；The signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal, including：When the signal in feedback Curve in, do not include signal curve corresponding with sample, or do not include signal curve corresponding with isolation gas column, or and sample When corresponding signal curve has abnormal, then judge to inhale sample operations exception.
- 4. the method for confirmatory sample sampling reliability as claimed in claim 1, it is characterised in that the printing opacity pipeline is transparent Pipeline, and/or, the photoelectric detection component includes an optical transmitting set and an optical receiver, the optical transmitting set and described Optical receiver forms light path, and at least a portion of the printing opacity pipeline passes through the light path.
- 5. as in Claims 1-4 a confirmation specimen sample reliability stated method, it is characterised in that also include：Part sample is preceding pushed away in the presence of the power source, in sampling probe discharges from forward tip, is grasped with carrying out a point sample Make；The sample post-tensioning by sampling probe, after sample operations are inhaled and before dividing sample operations, or positioned at dividing sample After operation, or positioned at dividing during sample operations.
- 6. a kind of device of confirmatory sample sampling reliability, including sampling probe and power source, it is characterised in that also include：Printing opacity pipeline, its one end are connected with the rear end of sampling probe, and the other end is connected with the power source；Photoelectric sensing component, it is arranged on printing opacity pipeline, and after carrying out suction sample operations for sampling probe, sampling probe is in institute In the presence of stating power source, when the sample in sampling probe is at least pulled at the photoelectric sensing component on printing opacity pipeline backward, instead Corresponding signal is fed out, wherein described be at least pulled to sample at photoelectric sensing component backward, after sampling probe inhales sample And divide before sample, or divide after sampling probe divides sample, or positioned at sampling probe during sample operations；Judging unit, for the signal fed back according to photoelectric sensing component, judge whether suction sample operations are normal.
- 7. the device as claimed in claim 6 for confirming sampling reliability, it is characterised in that the judging unit works as photoelectric sensing In the curve of the signal of component feedback, do not include signal curve corresponding with sample, or signal curve corresponding with sample is present When abnormal, then judge to inhale sample operations exception.
- 8. the device of confirmatory sample sampling reliability as claimed in claim 6, it is characterised in that judging unit works as photoelectric sensing In the curve of the signal of component feedback, do not include signal curve corresponding with sample, or do not include letter corresponding with isolation gas column Number curve, or when signal curve corresponding with sample has abnormal, then judge to inhale sample operations abnormal；Wherein, enter in sampling probe Before row inhales sample operations, isolation gas column is also established in sampling probe.
- 9. the device of confirmatory sample sampling reliability as claimed in claim 6, it is characterised in that characterized in that, described Light pipe road is transparent pipeline, and/or, the photoelectric detection component includes an optical transmitting set and an optical receiver, the light Transmitter and the optical receiver form light path, and at least a portion of the printing opacity pipeline passes through the light path.
- 10. the device of the confirmation sampling reliability as any one of claim 6 to 9, it is characterised in that the photoelectricity inspection Survey component and be arranged at rear end of the printing opacity pipeline close to sampling probe.
- 11. a kind of blood cell analyzer, including for inhale sample and divide the suction sample of sample divide sampling device, blood examination device, Input unit and display device for input instruction, it is characterised in that it is described suction sample divide sampling device include as claim 6 to The device of confirmation specimen sample reliability any one of 10, wherein, the instruction of input unit acceptance test, the suction sample point Sampling device draws sample and is supplied to blood test device, and blood test device detection sample obtains pattern detection result, described aobvious Showing device shows pattern detection result.
- 12. blood cell analyzer as claimed in claim 11, it is characterised in that when confirmatory sample sampling reliability When device judges to inhale sample operations exception：The display device does not show the pattern detection result or shows that result is unreliable near the pattern detection result Mark；And/orThe device of the confirmatory sample sampling reliability sends instructions to suction sample and divides sampling device to draw same sample again, to provide To blood test device, or, send instructions to suction sample and divide sampling device it is stopped providing sample to blood test device.
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