CN107677641A - A kind of helicobacter pylori diagnostor - Google Patents
A kind of helicobacter pylori diagnostor Download PDFInfo
- Publication number
- CN107677641A CN107677641A CN201710912463.9A CN201710912463A CN107677641A CN 107677641 A CN107677641 A CN 107677641A CN 201710912463 A CN201710912463 A CN 201710912463A CN 107677641 A CN107677641 A CN 107677641A
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- Prior art keywords
- white light
- laser
- central processing
- processing circuit
- helicobacter pylori
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
- G01N2021/396—Type of laser source
- G01N2021/399—Diode laser
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- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The present invention relates to medical diagnostic equipment field, more particularly to a kind of helicobacter pylori diagnostor, including：Central processing circuit, white light device, laser, band filters, PBS water chestnuts mirror, monochromatic light sub-lens, vacuum resonator, fibre optic repeater, condenser, PDAD, image decoder.Advantage：The diagnostor solves the problems, such as the error checkings such as the abnormal Biochemical changes false positive of medical treatment, is Non-invaive examination, automaticity height and simple operation and other advantages, can meet clinical medical workers' operation at different levels.
Description
Technical field
The present invention relates to medical diagnostic equipment field, more particularly to a kind of helicobacter pylori diagnostor.
Background technology
Helicobacter pylori has been confirmed as the main pathogenic of chronic gastritis, peptic ulcer.Helicobacter pylori infections
Gastric mucosa congestion, oedema can be caused, or even form rotten to the corn, ulcer, and it is closely related with stomach cancer.Therefore, helicobacter pylori
How quick infection is, Accurate Diagnosis is key subjects that current medical field faces.
Medical science, pharmacy, biology in, can with spectral technique to the medicine in biological fluid, anesthetic, excitant and its
Metabolite is analyzed, and Accurate Determining is carried out to the carbamate in blood, urine samples, to the melanocyte of dept. of dermatology
Cell tumour, the discriminating of mole and the diaper dermatitis as caused by candida albicans diagnose, and explore the formation mechenism of atherosclerosis
And process.Rapidly bacterium can also be classified and be differentiated, the structure of the large biological molecule such as research protein, nucleic acid, be ground
Study carefully the complex system of cell and tissue, carry out early diagnosis of tumor and the clinical medicine auxiliary diagnosis of other a variety of diseases, evaluation
Various preparation formulations, the crystal formation of polymorph medicine and the relation of drug effect are studied, distinguish medicine isomer, study pharmaceutical synthesis
In chemical reaction course, the purity and quality of evaluation response product etc..In addition, infrared spectrum for drug identification foundation it
One, the chemical constitution of unknown medicine can also be determined with reference to other Spectrum Analysis.
At present, the main method that medical field is used for helicobacter pylori infections in Diagnosis of Gastric is stomach lining pathological biopsy method, is suffered from
Person needs to be subjected to the pain of living-body tissue sampling, simultaneously because helicobacter pylori is easily caused false positive mistaken diagnosis in stove distribution.Cause
And urgently need to develop a set of efficient, accurate helicobacter pylori diagnostor.
The content of the invention
The present invention in view of the shortcomings of the prior art, proposes a kind of helicobacter pylori diagnostor, solves medical abnormal biochemical
Change the error checking problems such as false positive.
To achieve the above object, the present invention adopts the following technical scheme that：
The present invention proposes a kind of helicobacter pylori diagnostor, including：Central processing circuit, white light device, laser, frequency band filter
Light device, PBS water chestnuts mirror, monochromatic light sub-lens, vacuum resonator, fibre optic repeater, condenser, PDAD, image solution
Code device；
Vacuum resonator, fibre optic repeater, condenser pass sequentially through optical fiber connection, the PDAD, figure
As decoder, central processing circuit are sequentially connected electrically, the white light device, laser are connected with central processing circuit simultaneously, described
White light device, laser are connected with band filters simultaneously；
The central processing circuit starts the white light device by sending instruction, laser is started working, the diode
Array detector is transmitted into the central processing circuit to the picture signal of capture, and the central processing circuit is to picture signal
Analyzed in real time, and export analysis result.
Preferably, the filter include optical filtering, wavelength division multiplexer, collimating mirror, the optical filtering simultaneously light connects extremely
The wavelength division multiplexer, and optical signal is transmitted to the PBS water chestnuts mirror by the collimating mirror.
Preferably, the filter includes all-pass optical filtering, the bandpass filter mirror of light connects in parallel, the all-pass filter
Light microscopic is used to carry out white light all-pass optical filtering, and the bandpass filter mirror is used for laser bandpass filter.
Preferably, the monochromatic light sub-lens receive the optical signal of the PBS water chestnuts mirror, and optical signal is carried out monochromatic light screening,
After correction, transmit to the vacuum resonator.
Preferably, the laser includes laser diode, the laser constant-current circuit being connected with each other, the laser Constant Electric Current
Road is connected with central processing circuit, and the laser diode is connected with the bandpass filter mirror in band filters, the laser two
Pole pipe performs laser constant-current circuit and receives the laser intensity signal instruction from central processing circuit, adjusts laser power and passes through
Bandpass filter mirror carries out beam emissions.
Preferably, the white light device includes white light-emitting diodes, the white light constant-current circuit being connected with each other, the white light Constant Electric Current
Road is connected with central processing circuit, and the white light-emitting diodes is connected with the all-pass optical filtering in band filters, the white light two
Pole pipe performs white light constant-current circuit and receives the white light intensity signal instruction from central processing circuit, adjusts white light power and passes through
All-pass optical filtering carries out beam emissions.
Preferably, the central processing circuit model LPC1113, the circuit：Start white light device by sending instruction, swash
Light device is started working, and drives the white light device, laser to produce the light for meeting intensity requirement, and accurate light beam is carried out to analysis sample
Transmitting；The signal captured is analyzed, and exports pathological analysis result.
Preferably, described image decoder concrete model is ADV212.
Beneficial effects of the present invention：The helicobacter pylori diagnostor of the present invention, solves the false sun of the abnormal Biochemical changes of medical treatment
Property etc. error checking problem, be Non-invaive examination, automaticity is high and simple operation and other advantages, can meet clinical doctors at different levels
Be engaged in human users.
Brief description of the drawings
With accompanying drawing, the invention will be further described, but the embodiment in accompanying drawing does not form any limitation of the invention.
Fig. 1 is the example structure schematic diagram of helicobacter pylori diagnostor one of the present invention.
Embodiment
Technical solution of the present invention is further described with embodiment below in conjunction with the accompanying drawings, this is the preferable reality of the present invention
Apply example.
As shown in figure 1, the present invention proposes a kind of helicobacter pylori diagnostor, including：Central processing circuit, white light device, swash
Light device, band filters, PBS water chestnuts mirror, monochromatic light sub-lens, vacuum resonator, fibre optic repeater, condenser, diode array inspection
Survey device, image decoder；
Vacuum resonator, fibre optic repeater, condenser pass sequentially through optical fiber connection, PDAD, image solution
Code device, central processing circuit are sequentially connected electrically, and white light device, laser are connected with central processing circuit simultaneously, white light device, laser
It is connected simultaneously with band filters.
In the present embodiment, central processing circuit sends instruction startup white light device by time-multiplexed mode, laser is opened
Beginning work；Wherein, time division multiplexing in the present embodiment, is advantageous to save instruction resource, and improve operating efficiency.
In transmitting terminal, the laser provided with offer continuous spectrum, including the laser diode of interconnection, laser Constant Electric Current
Road, laser constant-current circuit are connected with central processing circuit, and laser diode is connected with the bandpass filter mirror in band filters, are swashed
Optical diode performs laser constant-current circuit and receives the laser intensity signal instruction from central processing circuit, and adjustment laser power is simultaneously
Beam emissions are carried out by bandpass filter mirror.
In transmitting terminal, the white light device of wide-band spectrum, including the white light-emitting diodes of interconnection, white light constant current are also provided with
Circuit, white light constant-current circuit are connected with central processing circuit, and white light-emitting diodes is connected with the all-pass optical filtering in band filters,
White light-emitting diodes performs white light constant-current circuit and receives the white light intensity signal instruction from central processing circuit, adjusts white light power
And beam emissions are carried out by all-pass optical filtering.
The spectrum excited passes through the pretreatment of filter, and filter includes optical filtering, wavelength division multiplexer, collimating mirror, filters
Mirror simultaneously to wavelength division multiplexer, and by optical signal by half-wave circulator transmitted to PBS water chestnut mirrors by light connects.Wherein, filter bag
All-pass optical filtering, the bandpass filter mirror of light connects in parallel are included, all-pass optical filtering is used to carry out all-pass optical filtering, bandpass filter to white light
Mirror is used for laser bandpass filter.Continuous spectrum laser sends broadband light wave and enters bandpass filter mirror, bandpass filter mirror
One or more of wavelength may be selected to pass through.White light, which sends broadband continuous spectrum, can scan the analysis wavelength of majority, utilize
Bandpass filter mirror can be restricted to required frequency band, be advantageous to improve the purity of spectrum.Wavelength division multiplexer provides required double light
Passage is composed, light is changed into directional light by collimating mirror, obtains the spectrum to be balanced each other with incident direction.
Optical signal is transmitted to PBS water chestnut mirrors by half-wave circulator, and a part of light is reflexed in analysis sample, other
Reflection loss of light.To the light in analysis sample, some reflects back into PBS water chestnut mirrors for direct projection, and reflectance-transmittance PBS water chestnuts mirror arrives again
In monochromatic light sub-lens.
In receiving terminal, monochromatic light sub-lens receive the optical signal of PBS water chestnut mirrors, and after carrying out monochromatic light screening, correction to optical signal,
Transmit to vacuum resonator.Vacuum resonator under vacuum conditions, allow needed for single-frequency spectrum by and being purified.
Due to the loss of optical filter, PBS water chestnuts mirror and vacuum resonator, the energy of light is difficult to shine directly into diode battle array
Efficient diagnosis is carried out in row detector, it is necessary to which the relaying that repeater is moved by light amplifies, and is transmitted through the fiber to condenser and arrives
PDAD.Wherein, condenser can strengthen light energy optocoupler altogether, be advantageous to meet diode array inspection
Survey the detection sensitivity of device.PDAD is transmitted into central processing circuit to the picture signal of capture, centre
Reason circuit is analyzed picture signal in real time, and exports pathological analysis result.Wherein, the image decoding utensil in the present embodiment
Body model ADV212.
Central processing circuit model LPC1113, the circuit：Startup white light device, laser is instructed to start work by sending
Make, driving white light device, laser produce the light for meeting intensity requirement, and accurate beam emissions are carried out to analysis sample；To being captured
Signal analyzed, and export pathological analysis result.
Helicobacter pylori diagnostor provided by the invention, using broadband white light device, continuous spectrum laser, for specific
Different human body tissue chooses different wave length, the imaging of EO-1 hyperion high-resolution confocal is obtained, in combination with photoimaging technology, by height
Spectral imaging technology, reflective conjugate focus imaging technique are combined, and form multispectral optical imaging system, compensate for single mould
State is imaged on the deficiency in terms of helicobacter pylori diagnosis, and compared with single-mode technology, two-film technique provides more complete information,
Accuracy and specificity of helicobacter pylori diagnosis etc. are improved, multispectral, high-resolution bimodal optical molecular image is realized, is
Helicobacter pylori diagnoses and clinical research provides new technological means, is advantageous to the raising of helicobacter pylori diagnostic level.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (8)
1. a kind of helicobacter pylori diagnostor, including central processing circuit, it is characterised in that also include：White light device, laser,
Band filters, PBS water chestnuts mirror, monochromatic light sub-lens, vacuum resonator, fibre optic repeater, condenser, PDAD,
Image decoder；
The vacuum resonator, fibre optic repeater, condenser pass sequentially through optical fiber connection, the PDAD, figure
As decoder, central processing circuit are sequentially connected electrically, the white light device, laser are connected with central processing circuit simultaneously, described
White light device, laser are connected with band filters simultaneously；
The central processing circuit starts the white light device by sending instruction, laser is started working, the diode array
Detector is transmitted into the central processing circuit to the picture signal of capture, and the central processing circuit is carried out to picture signal
Analysis in real time, and export analysis result.
2. helicobacter pylori diagnostor according to claim 1, it is characterised in that the filter includes optical filtering, ripple
Division multiplexer, collimating mirror, light connects pass through the collimating mirror to the optical filtering to the wavelength division multiplexer, and by optical signal simultaneously
Transmit to the PBS water chestnuts mirror.
3. helicobacter pylori diagnostor according to claim 2, it is characterised in that the filter includes light in parallel
All-pass optical filtering, the bandpass filter mirror of connection, the all-pass optical filtering are used to carry out all-pass optical filtering, the bandpass filter to white light
Mirror is used for laser bandpass filter.
4. helicobacter pylori diagnostor according to claim 1, it is characterised in that described in the monochromatic light sub-lens receive
The optical signal of PBS water chestnut mirrors, and after carrying out monochromatic light screening, correction to optical signal, transmit to the vacuum resonator.
5. helicobacter pylori diagnostor according to claim 1, it is characterised in that the laser includes what is be connected with each other
Laser diode, laser constant-current circuit, the laser constant-current circuit are connected with central processing circuit, the laser diode and frequency
With the bandpass filter mirror connection in filter, the laser diode performs the reception of laser constant-current circuit and comes from central processing circuit
Laser intensity signal instruction, adjustment laser power simultaneously pass through bandpass filter mirror carry out beam emissions.
6. helicobacter pylori diagnostor according to claim 1, it is characterised in that the white light device includes what is be connected with each other
White light-emitting diodes, white light constant-current circuit, the white light constant-current circuit are connected with central processing circuit, the white light-emitting diodes and frequency
With the all-pass optical filtering connection in filter, the white light-emitting diodes performs the reception of white light constant-current circuit and comes from central processing circuit
White light intensity signal instruction, adjustment white light power simultaneously pass through all-pass optical filtering carry out beam emissions.
7. according to any described helicobacter pylori diagnostors of claim 1-6, it is characterised in that the central processing circuit type
Number it is LPC1113, the circuit：Start white light device, laser start-up operation by sending to instruct, drive the white light device, laser
Device produces the light for meeting intensity requirement, and accurate beam emissions are carried out to analysis sample；The signal captured is analyzed, and it is defeated
Go out pathological analysis result.
8. helicobacter pylori diagnostor according to claim 7, it is characterised in that described image decoder concrete model is
ADV212。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710912463.9A CN107677641A (en) | 2017-09-29 | 2017-09-29 | A kind of helicobacter pylori diagnostor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710912463.9A CN107677641A (en) | 2017-09-29 | 2017-09-29 | A kind of helicobacter pylori diagnostor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107677641A true CN107677641A (en) | 2018-02-09 |
Family
ID=61138745
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710912463.9A Pending CN107677641A (en) | 2017-09-29 | 2017-09-29 | A kind of helicobacter pylori diagnostor |
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| CN2530263Y (en) * | 2002-03-08 | 2003-01-08 | 中国科学院上海光学精密机械研究所 | Optical fibre sensor for detecting bioluminescence |
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