CN107648611A - The anti-cicatrix externally used preparation of compound Angiotensin-Converting class - Google Patents

The anti-cicatrix externally used preparation of compound Angiotensin-Converting class Download PDF

Info

Publication number
CN107648611A
CN107648611A CN201710842474.4A CN201710842474A CN107648611A CN 107648611 A CN107648611 A CN 107648611A CN 201710842474 A CN201710842474 A CN 201710842474A CN 107648611 A CN107648611 A CN 107648611A
Authority
CN
China
Prior art keywords
triamcinolone acetonide
scar
bulbus allii
allii cepae
hoe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710842474.4A
Other languages
Chinese (zh)
Inventor
谈伟强
施帮辉
张利云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang University ZJU
Original Assignee
Zhejiang University ZJU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang University ZJU filed Critical Zhejiang University ZJU
Priority to CN201710842474.4A priority Critical patent/CN107648611A/en
Publication of CN107648611A publication Critical patent/CN107648611A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a kind of anti-cicatrix externally used preparation of compound Angiotensin-Converting class, is made up of one or more ACE classes medicines and other one or more anti-scarring drugs for active principle, and the mass concentration of active ingredient is 0.05% 25% in preparation.ACE classes medicine is the related active peptides of ACE and corresponding inhibitor/antagonist, and other anti-scarring drugs are Triamcinolone acetonide, heparin, Bulbus Allii Cepae extract, asiaticosid.Invention formulation cost of material is cheap, low manufacture cost, can reduce treatment cost.The active ingredient of invention formulation is uniformly distributed in preparation in mass ratio, has the ability for preferably penetrating skin barrier, be can be done directly on scar and is carried out multi-angle synergistic treatment, is expected to improve curative effect, is reduced side reaction.This preparation is local topical medicine, is mainly used in the treatment of cicatrix of skin.

Description

The anti-cicatrix externally used preparation of compound Angiotensin-Converting class
Technical field
The invention belongs to field of medicaments, and in particular to a kind of compound Angiotensin-Converting (Angiotensin Converting enzyme, ACE) the anti-cicatrix externally used preparation of class (ACE related activities peptide and its corresponding inhibitor/antagonist) and It is prepared.
Background technology
Scar (scar, scar, cicatrix) be caused normal skin tissue after various wounds mode of appearance and The general designation of the change of histopathology.After it is human body wound, one kind during wound or surface of a wound normal healing is normal, Inevitable physiological reaction, and the inevitable outcome of wound healing process.The essence of scar is that one kind does not possess normal skin tissue Structure and physiological function, losing normal structure vigor, abnormal, unsound tissue.
Cicatricial tissue hyperplasia is then likely to form hypertrophic scar, influences the outward appearance of patient, causes cacesthesia, influences The function of local skin.Wound healing of the skin after sustaining damage goes through several stages：Inflammatory phase, proliferative phase and remodeling phase. In proliferative phase, body by cytothesis, differentiation and ECM (extracellular matrix) formed supplement or repair due to skin injury and Cause the tissue for lacking or being damaged.In proliferative phase, the cell of several approach repair tissues is referred to as repair cell more than, into fibre Dimension cell is one kind of repair cell, and is formed in fibr tissue and played an important role with links such as contraction of wounds；Work as tissue After the completion of reparation, fibroblast is mainly disappeared by the form of Apoptosis.When fibroblast because of some specific reasons again When raw increase, apoptosis are reduced, fibr tissue is formed to increase to shrink with granulation tissue and strengthened, thus hypertrophic scar produces.Therefore Regulation and control to fibroblast regeneration, differentiation perhaps can provide a kind of effective way for suppressing cicatrization.
Fibroblastic propagation is with differentiation mainly by the shadow of cell factor, mechanical stress and extracellular matrix microenvironment Ring.Wherein TGF-β 1 stimulates fibroblast proliferation by TGF-β signal path and migrated to wound；It can induce into fibre simultaneously Endochylema of the cell synthesis rich in collagen is tieed up, myofibroblast is divided into so as to induce fibroblast.Endothelium Local angiotensin system of myocardial (renin-angiotensin system, RAS) plays key player in TGF-β signal path.
In recent years RAS research is found：Local RAS can be a variety of by promoting the synthesis of cell propagation and extracellular matrix to participate in The formation of histoorgan fibrosis.From the proangiotensin of liver, angiotensin I is converted into the presence of feritin (angiotensin I, Ang I), Ang I are converted into Angiotensin II (angiotensin II, Ang in the presence of ACE II), Ang II are secreted into target tissue by blood circulation, are combined with I receptors, cause aldosterone release and vessel retraction etc. raw Effect is managed, blood pressure and the blood flow change of body is adjusted, maintains body blood volume and water-electrolyte balance.Constantly there is scholar both at home and abroad The expression for having RAS is found in local organizations such as heart, vascular wall, kidney, fat and brains；Local RAS is independent action, but Influenced each other again with circulation RAS, participate in a variety of pathophysiological processes jointly.
There is also complete RAS (McGinn R, Meade RD, Kenny GP.Angiotensin II in for skin histology human skin:an age-dependent role for core temperature regulationAm J Physiol Heart Circ Physiol.2015,308(10):H1192-3).After normal skin is impaired, RAS is activated, and participates in tissue Injury repair and later stage tissue reconstruction process.In hyperplastic scar forming process, ACE and Ang II expression increase, and ACE Activity is significantly higher than normal and trauma skin.The TGF-β signal path that Ang II are mediated by its I receptor induces human desmocyte The propagation of cell, and this propagation can be suppressed by the antagonist of this receptor (rather than II receptors).
It is the shearing enzyme (Fig. 1) of Several Active Peptides as the ACE of RAS system hinges.Its substrate is except above-mentioned AngI, in addition to Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (Substance P, SP), N- acetyl group-seryl-aspartoyl-lysyl-proline (N- Acetyl-seryl-aspartyl-lysyl-proline, AcSDKP), angiotensins-(1-7) (hypertensin 1-7, Ang 1-7), bradykinin (Bradykinin), enkephalins (Enkephalin), neurotensin (Neurotensin), Chemotactic Peptide (N- formyl-methionines-Ile-Phe, N-formyl-Met-Leu-Phe, fMLF), insulin B chain (Insulin b chain) and amyloid (Amyloid peptides) Ab1-40 and Ab1-42 etc. (Bernstein KE, Ong FS,Blackwell WL,Shah KH,Giani JF,Gonzalez-Villalobos RA,Shen XZ,Fuchs S, Touyz RM.A modern understanding of the traditional and nontraditional biological functions of Angiotensin-converting enzyme.Pharmacol Rev.2012,65 (1):1-46.)。
Exogenous SP can effectively facilitate fibroblast proliferation, so as to promote cicatrization.On the contrary, another dropped by ACE The substrate A cSDKP of solution can then alleviate fibrosis.In addition, though ACE and other enzymes participate in Ang 1-7 formation jointly, but it is also Degrade its main peptase.Ang 1-7 have the function that anti-tissue fibrosis, and its mechanism is relevant with suppressing TGF-β path.It is slow to swash The B2 receptor antagonists of peptide can weaken glomerulosclerosis and myocardial fibrosis, and its B1 acceptor gene knockout can mitigate kidney fibrous Change, B1 receptor antagonists can improve glomerulonephritis, but bradykinin is main related to vessel retraction.
Although detecting that enkephalins increases in hyperplastic scar, it acts on the mainly itch with cicatricial tissue, pain It is related etc. cacesthesia.Neurotensin is mainly distributed on brain and intestines and stomach, mainly to blood pressure control, stress, pain etc. it is related； The peptide and its activator are possibly as potential tranquilizer, antalgesic and depressor.Other 3 kinds of active peptides also temporarily have no document report Road is related to cicatrization, and wherein Chemotactic Peptide fMLF mainly plays the role of smooth muscle contraction, insulin B chain mainly with diabetes phase Close, Ab1-40 and Ab1-42 are mainly related to the pathogenesis of alzheimer disease.
To sum up, this 5 ACE related activities peptides of Ang II, SP, AcSDKP, Ang 1-7 and bradykinin and its corresponding inhibitor (including the antagonist of Ang II, SP and bradykinin, and AcSDKP, Ang 1-7 and ACE inhibitor) and fibrosis and scar Formed related.According to literature query and our research, play facilitation is：Ang II, SP, AcSDKP inhibitor (used in us is (that used in us is AcSDKP prolyl endopeptidase inhibitor S-17092), Ang 1-7 inhibitor Ang 1-7 MAS acceptor inhibitor A779) and bradykinin；And play inhibitory action is ACEI (ACE Inhibitors, blood Angiotensin converting enzyme inhibitor), ARB (Angiotensin Receptor Blocker, angiotensin-ii-receptor retardance Agent), SP antagonist (that used in us is SP NK1 receptor antagonist L-733060), AcSDKP, Ang 1-7, bradykinin Antagonist (that used in us is B1 receptor antagonist DALBK and B2 the receptor antagonist HOE-140 of bradykinin).
Wherein, ACEI and ARB has clinically been widely used in the treatment of hypertension.In addition, ACEI is also applied to control Congestive heart failure, heart infarction, diabetic nephropathy and diabetes mellitus hypertension, high-risk-type angiocardiopathy etc. are treated, ARB can also be used for changing Mercy declined, treatment after heart infarction, diabetic nephropathy, left ventricular hypertrophy, atrial fibrillation, metabolic syndrome and the clinics such as ACEI is cough caused are asked Topic.Experimental study confirms that ACEI and ARB can be played in the pathologic processes such as Ventricular Remodeling, glomerulus fibrosis, pulmonary fibrosis Improved effect.Although find that some ACE classes medicines have the function of suppressing fibrosis in experimental study, clinically not Have maturation using ACE classes medicine as principle active component suppressing the medicine of cicatrization.
Triamcinolone acetonide, heparin, Bulbus Allii Cepae extract, asiaticosid etc. are mainly having for current clinical conventional anti-scar drug cream Composition is imitated, suppresses cicatrization by different approaches.Hormone medicine (predominantly Triamcinolone acetonide) early in the sixties in 19th century just By clinical practice in the treatment of scar, local injection hormone is the first-line treatment method of keloid at present, and Hypertrophic The second line treatment method of scar, the effect that hormone suppresses scar proliferation mainly have benefited from its powerful anti-inflammatory, antipruritic and suppression carefully Born of the same parents and the function of revascularization.Heparin plays the role of anti-inflammatory, antiallergy, suppression fibroblast proliferation and promotion organization hydration, Collagen structure can be made to become loose；Contain substantial amounts of anti-inflammatory and polyphenoils in Bulbus Allii Cepae extract, there is in vitro study to show that onion carries Take thing to reduce fibroblast proliferation, collagen formation and extracellular matrix to be formed；Contractubex is clinically commonly used at present i.e. simultaneously Contain heparin and Bulbus Allii Cepae extract.Asiaticosid (Asiaticoside, asiaticoside, asiaticoside) is that the biology extracted from centella is living Property material, have the function that promote Wound healing, reduce collagen I and collagen I II formation, and with anti-inflammatory function, be commonly used to As wound or the auxiliary treatment of scar.
Oral method of administration can pass through the first pass effect of digestive system, and oral ARB and ACEI may have blood pressure reduction Side effect, and oral hormone class medicine can cause Cushing syndrome etc., and the local drug concentration of scar also may not be high.It is transdermal Medicine-feeding technology is that one kind improves the technology of Medicated Permeation by either physically or chemically, can effectively improve medicine local action Depth, first pass effect of the digestive system to medicine is avoided, reduce medicine usage amount and reduce the adverse reaction of medicine.This patent leads to Cross selection drug regimen and matched, prepare external preparation, above-mentioned anti-scar composition is preferably passed through keratoderma, arrive Up to cicatricial tissue, acted synergistically by number of ways so as to preferably reach the purpose for suppressing cicatrix of skin and being formed.
The content of the invention
It is an object of the invention to provide a kind of anti-cicatrix externally used preparation of compound Angiotensin-Converting (ACE) class, it is used for The treatment of cicatrix of skin, and with the ability for preferably penetrating skin barrier.The preparation is by one or more ACE classes medicines (ACE related activities peptide and its corresponding inhibitor/antagonist) and other one or more anti-scarring drugs form for active principle. The mass concentration of active ingredient (including ACE classes medicine and other anti-scarring drugs) is 0.05%-25% in preparation.The ACE Class medicine refers to ARB (ARB), N- acetyl group-seryl-aspartoyl-lysyl-proline (AcSDKP), hypertensin 1-7 (Ang 1-7), the antagonist L-733060 of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP), the antagonist DALBK of bradykinin With HOE-140 and angiotensin converting enzyme inhibitor (ACEI)；Wherein, ARB is mainly selected from Losartan (Losartan), strategic point Bei Shatan (Irb, Irbesartan), Valsartan (Valsartan), Telmisartan (Telmisartan), Olmesartan (Olmesartan), Candesartan (Candesartan) etc.；ACEI is mainly selected from lisinopril (Lisinopril), Lei meter Pu Sharp (Ramipril), captopril (Captopril), Cilazapril (Cilazapril), enalapril (Enalapril), shellfish That Puli (Benazepril) etc..
Other anti-scarring drugs are from Triamcinolone acetonide, heparin, Bulbus Allii Cepae extract, asiaticosid etc..Said medicine is to face Bed anti-scarring drug active ingredient, and medicine material is easily bought.
The mode of many of ACE classes effective ingredient combination is：1) ARB combines (quality proportioning 0.33- with ACEI 3:0.33-3；Combine reason：ARB can suppress this very strong scar proliferation factor of Ang II, but other active peptides can not be produced Effect；Further suppress Ang II after adding ACEI, while AcSDKP and Ang 1-7 increase, the above is more beneficial for suppressing scar Trace；But after adding ACEI, SP and bradykinin increase due to lacking ACE degraded, have cause becoming for scar proliferation in theory Gesture)；2) ARB and SP antagonist-combination (quality proportioning 0.33-3:0.33-3；Combine reason：The combination inhibits Ang II The two very strong scar proliferation factors with SP, but other active peptides are not worked)；3) ACEI and SP antagonist, slow swash Antagonist-combination (the quality proportioning 0.33-3 of peptide:0.33-3:0.33-3；Combine reason：ACEI reduces Ang II, AcSDKP Increase with Ang 1-7, the above is advantageous to suppress scar；But SP and bradykinin increase due to lacking ACE degraded, theoretical On can cause scar proliferation, therefore add its antagonist and suppressed；All scar proliferation factors related such then ACE all obtain Suppress)；4) ARB combines SP antagonist, antagonist-combination (the quality proportioning 0.33-3 of bradykinin:0.33-3:0.33-3； Combine reason：The combination inhibits the two very strong scar proliferation factors of Ang II, SP, and also inhibits bradykinin, this is stronger Scar proliferation factor, but other active peptides are not worked)；5) ARB combines SP antagonist, the antagonist of bradykinin, with And AcSDKP, Ang 1-7 combination (quality proportioning 0.33-3:0.33-3:0.33-3:0.33-3:0.33-3；Combine reason：Should Combination inhibit the two very strong scar proliferation factors of Ang II, SP, also inhibits this stronger scar proliferation of bradykinin because Element, while increasing for AcSDKP and Ang 1-7 is also beneficial to suppress scar, all scar proliferation factors related so then ACE All it is inhibited).Other combinations can suppress fibrosis and scar situation and principle (Fig. 1) according to ACE derive and The selection of medicine.When several drugses combine, usually wait mass mixing, if necessary the quality of any component can on the quality such as be transferred to When 3 times of highest or minimum 1/3 times when the quality such as being adjusted downward to.
The combination of active principles mode of other many of anti-scarring drugs is：1) Triamcinolone acetonide extracts with heparin, onion Thing combines (quality proportioning 0.33-3:0.33-3:0.33-3；Combine reason：Anti-inflammatory, soften scar)；2) Triamcinolone acetonide and product Asiaticoside combines (quality proportioning 0.33-3:0.33-3；Combine reason：Anti-inflammatory, promote to repair)；3) Bulbus Allii Cepae extract, heparin (quality proportioning 0.33-3 is combined with asiaticosid:0.33-3:0.33-3；Combine reason：Anti-inflammatory, softening scar, promote to repair It is multiple)；4) Triamcinolone acetonide combines (quality proportioning 0.33-3 with Bulbus Allii Cepae extract, heparin and asiaticosid:0.33-3:0.33-3: 0.33-3；Triamcinolone acetonide has very strong antiinflammatory action after combining heparin and Bulbus Allii Cepae extract, while can soften scar and promotion Repair)；5) heparin combines (quality proportioning 0.33-3 with Bulbus Allii Cepae extract:0.33-3；Combine reason：Anti-inflammatory, softening scar). Also other combinations can be selected according to action principle if necessary.When several drugses combine, mass mixing is usually waited, it is necessary former The quality of one component can on 3 times of highest when the quality such as being transferred to or minimum 1/3 times when the quality such as being adjusted downward to.
The anti-cicatrix externally used preparation of compound ACE classes of the present invention, specific formulation can be solution (tincture and spirit), powder Agent, lotion, liniment, finish, emulsion (containing creme), ointment (containing emulsifiable paste), paste, plaster, gel, plastics, aerosol (spray Mist agent), emplastrum (rubber ointment, Babu plaster, bar cloth patch and other patches and paste etc.), other are (such as dissolved in diformazan Formulation of base sulfoxide etc.).Active ingredient has bigger difference with specific formulation difference in preparation；Usual each component is all etc. that quality is mixed Close, if necessary the quality of any of which component can on 3 times of highest when the quality such as being transferred to or minimum 1/ when the quality such as being adjusted downward to 3.Active ingredient is uniformly distributed in auxiliary element, i.e., in external preparation excipient, excipient may include adhesive, filler, collapse Agent, lubricant, emulsifying agent, transdermal enhancer, preservative, aromatic, colouring agent etc. are solved, can be made by the selection and proportioning of excipient Go out the external used medicine of different dosage forms and the optimum formula of certain formulation external used medicine；Auxiliary element can increase active ingredient and penetrate The ability of skin barrier, and one or more of transdermal enhancers can be contained.
The present invention has advantages below：(1) ACE classes medicine has clinically had certain application, especially ACEI and ARB Application it is very extensive, its security is self-evident, and its pharmacology, pharmacokinetics, toxicological study are fairly perfect.(2) Qu An Nai De, heparin, Bulbus Allii Cepae extract, asiaticosid etc. have clinically been widely used, and its security and pharmaceutical research are Through fairly perfect；(3) compared with clinically conventional single component steroids external application anti-scarring drug, compound ACE class medicines resist Scar preparation can reduce the adverse reaction of hormone by not having to or reducing the hormone concentration in preparation；(4) with it is clinically normal Silicone anti-scarring drug is compared, and invention formulation cost of material is very cheap, low manufacture cost, can greatly reduce patient Financial burden, reduce treatment cost.(5) although the expression for reducing local T GF- β can improve cicatrization and know together, at present The improvement scar medicine clinically applied with suppress inflammation (steroids, trade name " triamcinolone acetonide acetate urea cream " etc.), Anti-inflammatory and softening scar (trade name " Contractubex " etc.), wound healing (trade name " asiaticoside frost " etc.), silica gel piece (trade name " U.S. skin shield ", " celestial being card " etc.) and pressure therapy (Silica hydrogel pad pasting, trade name " easypro trace ", " easypro trace again ", " apply Can answer " etc.) based on；Laboratory research have transfected using gene, antibody etc. reduces TGF-β, but temporarily has no matured product；Document Confirm that ACE related activities peptide/inhibitor can influence the expression of TGF-β in vitro with our early-stage Study, partly have very well Reduction TGF-β effect, the present invention is expected to fill up the market vacancy.(6) the anti-cicatrix externally used preparation of compound ACE classes has multiple Pharmacological action, scar is acted synergistically on from multi-angle, play more preferable anti-scar effect；Meanwhile patient only needs to use one kind Medicine, also can convenient use, increase compliance, so as to increase curative effect.
Brief description of the drawings
Fig. 1 is the metabolism of the fibrosis related activity peptide of Angiotensin-Converting (ACE) regulation and control.
Fig. 2 is the making of mouse back incisional scar model.
Fig. 3 is Ang II immunohistochemical experiment results, and K is ACE gene knockout groups, and R is Ramipril group, and H is that hydrazine benzene is rattled away Piperazine low blood pressure control group, B are blank control group.
Fig. 4 is Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 immunohistochemical experiment result, and K is ACE gene knockout groups, and R is Ramipril group, and H is hydralazine Low blood pressure control group, B are blank control group.
Fig. 5 is Ang 1-7 immunohistochemical experiment results, and K is ACE gene knockout groups, and R is Ramipril group, and H is that hydrazine benzene is rattled away Piperazine low blood pressure control group, B are blank control group.
Fig. 6 is Angiotensin II, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, the average ash of hypertensin 1-7 that each group measures under ImageJ softwares Spend (optical density) value.
Fig. 7 is concentration of the AcSDKP in cicatricial tissue, is from left to right ACE gene knockout groups, Ramipril group, hydrazine benzene Pyridazine low blood pressure control group and blank control group.
Fig. 8 is NIH3T3 cells cell proliferative conditions under ACE related activities peptide or inhibitor effect.
Fig. 9 is that NIH3T3 cells collagen under ACE related activities peptide or inhibitor effect generates situation.
Embodiment
The present invention is further described in conjunction with the accompanying drawings and embodiments.The Bulbus Allii Cepae extract used in embodiment and centella Glycosides etc. can be bought from medicine material company.
Embodiment 1 0.05% compound ACE classes medicine (0.03%ARB+0.02% triamcinolone acetonide acetates) anti-scar containing urea The preparation of ointment
By taking Losartan Potassium+triamcinolone acetonide acetate as an example：By magnesium stearate 8.5g, white oil in 70 DEG C of waters bath with thermostatic control 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；Distilled water is taken in 70 DEG C of waters bath with thermostatic control 32mL is added in 100ml beakers and is heated to 70 DEG C, is added urea 10g dissolvings and is used as aqueous phase；30mg chlorine is weighed with electronic balance Husky smooth potassium and 20mg triamcinolone acetonide acetates, Losartan Potassium add aqueous phase dissolved, and triamcinolone acetonide acetate adds oil phase dissolving；Finally will Aqueous phase oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.05% compound ACE classes medicine (0.03%ARB+0.02% triamcinolone acetonide acetates) anti-scar ointment containing urea.
Ratio by changing Losartan Potassium, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point Several compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
The system of embodiment 2 4% compound ACE classes medicine (1%ARB+3% triamcinolone acetonide acetates) anti-scar ointment containing urea It is standby
By taking Valsartan+triamcinolone acetonide acetate as an example：In 70 DEG C of waters bath with thermostatic control by magnesium stearate 8.5g, white oil 34g, Lanolin 14g is put into 100ml beakers, and heating is melted and stirred as oil phase；Distilled water 32mL is taken in 70 DEG C of waters bath with thermostatic control Add in 100ml beakers and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；With electronic balance weigh 1g Valsartans and 3g triamcinolone acetonide acetates, Valsartan add aqueous phase dissolved, and triamcinolone acetonide acetate adds oil phase dissolving；The mixing of water oil phase is sufficiently stirred And add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 4% compound ACE class medicines The preparation of (1%ARB+3% triamcinolone acetonide acetates) anti-scar ointment containing urea.
0.05-25% mass fractions can be obtained by the ratio for changing Valsartan, triamcinolone acetonide acetate and ointment bases Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
Embodiment 3 5% compound ACE classes medicine (2%ARB+3% triamcinolone acetonide acetates) anti-scar containing numerous emulsifiers is soft The preparation of cream
By taking Irbesartan+triamcinolone acetonide acetate as an example：By stearic acid 4.8g, octadecyl alcolol 4g, list in 70 DEG C of waters bath with thermostatic control Tristerin 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating and melting and the conduct that stirs Oil phase；Take distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to add Heat is to 70 DEG C and well mixed is used as aqueous phase；2g Irbesartans and 3g triamcinolone acetonide acetates, Irbesartan are weighed with electronic balance Aqueous phase dissolved is added, triamcinolone acetonide acetate adds oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, It is sealed in 5 DEG C of refrigerators.Above method obtains 5% compound ACE classes medicine (2%ARB+3% triamcinolone acetonide acetates) containing more The kind anti-scar ointment of emulsifying agent.
Ratio by changing Irbesartan, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point Several compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
Embodiment 4 3% compound ACE classes medicine (2%ARB+1% triamcinolone acetonide acetates) anti-scar normal saline solution Prepare
By taking Losartan Potassium+triamcinolone acetonide acetate as an example：Under room temperature condition, 100g normal saline solutions are weighed, with electronics day Flat weigh is sufficiently stirred in 2g Losartan Potassiums and 1g triamcinolone acetonide acetates addition physiological saline.Encapsulation preserves.Above method obtains 3% compound ACE classes medicine (2%ARB+1% triamcinolone acetonide acetates) anti-scar normal saline solution.
0.05-25% concentration is can obtain by changing physiological saline and Losartan Potassium, triamcinolone acetonide acetate quality proportioning Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar normal saline solution, with for different type scar or obtain most Good anti-scar effect.
The preparation of embodiment 5 20% compound ACE classes medicine (15%ARB+5% triamcinolone acetonide acetates) anti-scar gel
By taking Irbesartan+triamcinolone acetonide acetate as an example：Under room temperature condition, 72g normal saline solutions are weighed, add 15g strategic points Bei Shatan and 5g triamcinolone acetonide acetates fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C.Finally Add 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 0.2% compound ACE classes medicine (15%ARB+5% acetic acid Triamcinolone acetonide) anti-scar gel.
0.05-25% concentration is can obtain by changing physiological saline and Irbesartan, the quality proportioning of triamcinolone acetonide acetate Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar gel, for different type scar or to obtain optimal anti-scar Trace effect.
Embodiment 6 15% compound ACE classes medicine (5%ARB+10% triamcinolone acetonide acetates) anti-scar plastics preparation side Method
By taking Valsartan+triamcinolone acetonide acetate as an example：Weigh 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, 90 It is stirred well to and is completely dissolved in DEG C water bath with thermostatic control, add 3ml glycerine, stirs to well mixed.It is eventually adding 5g Valsartans With 10g triamcinolone acetonide acetates, it is stirred well to and is completely dissolved, is cooled to room temperature.Encapsulation preserves.
0.05-25% concentration is can obtain by changing plastics matrix and Valsartan, the quality proportioning of triamcinolone acetonide acetate Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar plastics, for different type scar or to obtain optimal anti- Scar effect.
The anti-scar bar cloth patch preparation method of the compound ACE classes medicine (6%ARB+2% triamcinolone acetonide acetates) of embodiment 7 8%
By taking Telmisartan+triamcinolone acetonide acetate as an example：In 50 DEG C of waters bath with thermostatic control, 6g Telmisartans and 2g acetic acid Qu An are taken Nai De, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1gEDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With Upper method obtains the anti-scar bar cloth patch of 8% compound ACE classes medicine (6%ARB+2% triamcinolone acetonide acetates).
By changing, bar cloth pastes matrix and a Telmisartan, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense The anti-scar bar cloth patch of compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) of degree, with optimal for different type scar or acquirement Anti- scar effect.
Embodiment 8 4% compound ACE classes medicine (3%ARB+1% triamcinolone acetonide acetates) anti-scar spray preparation method
By taking Losartan Potassium+triamcinolone acetonide acetate as an example：In 100g physiological saline, add 3g Losartan Potassiums and 1g acetic acid is bent An Naide and 1g urea, is stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Losartan Potassium, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates) anti-scar spray of degree, with optimal for different type scar or acquirement Anti- scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1%) of embodiment 9 3% contains urea The preparation of anti-scar ointment
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：By magnesium stearate in 70 DEG C of waters bath with thermostatic control 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70 DEG C of thermostatted waters Take distilled water 32mL to add in 100ml beakers in bath and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；With electronics day Flat to weigh 1g Losartan Potassiums, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, Losartan Potassium adds aqueous phase dissolved, and how is acetic acid Qu An Moral, Bulbus Allii Cepae extract add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 In DEG C refrigerator.Above method obtains 3% compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1%) and contained The anti-scar ointment of urea.
It can be obtained by the ratio for changing Losartan Potassium, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar containing urea of 0.05-25% mass fractions is soft Cream.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 3%ARB+1% triamcinolone acetonide acetates+1%) of embodiment 10 5% contains urea The preparation of anti-scar ointment
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：In 70 DEG C of waters bath with thermostatic control by magnesium stearate 8.5g, White oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；In 70 DEG C of waters bath with thermostatic control Take distilled water 32mL to add in 100ml beakers and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；Claimed with electronic balance 3g Valsartans, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates are taken, Valsartan adds aqueous phase dissolved, triamcinolone acetonide acetate, onion Extract adds oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 In DEG C refrigerator.Above method obtains 5% compound ACE classes medicine (Bulbus Allii Cepae extract of 3%ARB+1% triamcinolone acetonide acetates+1%) and contained The anti-scar ointment of urea.
0.05- can be obtained by the ratio for changing Valsartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar ointment containing urea of 25% mass fraction.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 10%ARB+10% triamcinolone acetonide acetates+5%) of embodiment 11 25% contains The preparation of the anti-scar ointment of numerous emulsifiers
By taking Irbesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：In 70 DEG C of waters bath with thermostatic control by stearic acid 4.8g, Octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting is simultaneously Stir as oil phase；Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g is taken to add in 70 DEG C of waters bath with thermostatic control It is heated to 70 DEG C in 100ml beakers and is well mixed to be used as aqueous phase；10g Irbesartans are weighed with electronic balance, 10g onions are extracted Thing and 5g triamcinolone acetonide acetates, Irbesartan add aqueous phase dissolved, and triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving； Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.It is multiple that above method obtains 25% Square ACE classes medicine (Bulbus Allii Cepae extract of 10%ARB+10% triamcinolone acetonide acetates+5%) anti-scar ointment containing numerous emulsifiers.
It can be obtained by the ratio for changing Irbesartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar containing urea of 0.05-25% mass fractions is soft Cream.
Embodiment 12 10% compound ACE classes medicine (Bulbus Allii Cepae extract of 6%ARB+2% triamcinolone acetonide acetates+1%) anti-scar The preparation of trace normal saline solution
By taking Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Under room temperature condition, it is water-soluble to weigh 100g physiology salts Liquid, weighed in 6g Telmisartans, 2g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates addition physiological saline with electronic balance and fully stirred Mix.Encapsulation preserves.Above method obtains 10% compound ACE classes medicine, and (onion of 6%ARB+2% triamcinolone acetonide acetates+1% is extracted Thing) anti-scar normal saline solution.
By changing physiological saline and Telmisartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract quality proportioning can obtain Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar normal saline solution of 0.05-25% concentration, With for different type scar or the optimal anti-scar effect of acquirement.
Embodiment 13 25% compound ACE classes medicine (Bulbus Allii Cepae extract of 15%ARB+5% triamcinolone acetonide acetates+5%) anti-scar The preparation of trace gel
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Under room temperature condition, it is water-soluble to weigh 72g physiology salts Liquid, add 15g Losartan Potassiums, 5g Bulbus Allii Cepae extracts and 5g triamcinolone acetonide acetates and fully dissolve, add 3g carboxymethyl celluloses Sodium, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 25% compound ACE classes medicine (Bulbus Allii Cepae extract of 15%ARB+5% triamcinolone acetonide acetates+5%) anti-scar gel.
By changing physiological saline and Losartan Potassium, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar gel of 0.05-25% concentration, with for not Same type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 14 0.3% (extract by the onion of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1% Thing) anti-scar plastics preparation method
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Weigh 8g polyvinyl alcohol (PVA) and be added to 88ml steamings In distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.Finally plus Enter 100mg Valsartans, 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates, be stirred well to and be completely dissolved, be cooled to room Temperature.Encapsulation preserves.
By changing plastics matrix and Valsartan, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain Compound ACE classes medicine (Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar plastics of 0.05-25% concentration, with pin To different type scar or obtain optimal anti-scar effect.
Embodiment 15 4% compound ACE classes medicine (Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1%) anti-scar Ba Bu pastes preparation method
By taking Irbesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：In 50 DEG C of waters bath with thermostatic control, take 2g Irbesartans, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, are dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving is stirred Mix uniformly, obtain B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, Cover adherent layer, stripping and slicing.Above method obtains 4% compound ACE classes medicine, and (onion of 2%ARB+1% triamcinolone acetonide acetates+1% carries Take thing) anti-scar bar cloth patch.
The quality proportioning that matrix and Irbesartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract are pasted by changing bar cloth can obtain The anti-scar bar cloth patch of the compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% concentration, with for Different type scar obtains optimal anti-scar effect.
Embodiment 16 18% compound ACE classes medicine (Bulbus Allii Cepae extract of 10%ARB+4% triamcinolone acetonide acetates+4%) anti-scar Trace spray preparation method
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：In 100g physiological saline, 10g Losartans are added Potassium, 4g Bulbus Allii Cepae extracts and 4g triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Losartan Potassium, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain Compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar spray of 0.05-25% concentration, with for Different type scar obtains optimal anti-scar effect.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1% of embodiment 17 5% Plain sodium) the anti-scar ointment containing urea preparation
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：By stearic acid in 70 DEG C of waters bath with thermostatic control Magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70 DEG C of constant temperature Take distilled water 32mL to add in 100ml beakers in water-bath and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；Use electronics Balance weighs 2g Valsartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins, and Losartan Potassium adds aqueous phase dissolved, Triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to Room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtain 5% compound ACE classes medicine (2%ARB+1% triamcinolone acetonide acetates+ The liquaemin of 1% Bulbus Allii Cepae extract+1%) the anti-scar ointment containing urea.
It can be obtained by the ratio for changing Valsartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases The compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) for obtaining 0.05-25% mass fractions contains urea Anti- scar ointment.
The compound ACE classes medicine of embodiment 18 0.4% (extract by the onion of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1% The liquaemin of thing+0.1%) the anti-scar ointment containing urea preparation
By taking Irbesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：By tristearin in 70 DEG C of waters bath with thermostatic control Sour magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70 DEG C of perseverances Take distilled water 32mL to add in 100ml beakers in tepidarium and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；Electricity consumption Sub- balance weighs 100mg Irbesartans, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, E Beisha Tanga enters aqueous phase dissolved, and triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；The mixing of water oil phase is sufficiently stirred And add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 0.4% compound ACE class medicines Thing (liquaemin of+0.1% Bulbus Allii Cepae extract of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1%) anti-scar ointment containing urea.
Can be with by the ratio for changing Irbesartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases The compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine The anti-scar ointment of element.
The compound ACE classes medicine (liver of+3% Bulbus Allii Cepae extract of 1%ARB+3% triamcinolone acetonide acetates+3% of embodiment 19 10% Plain sodium) the anti-scar ointment containing numerous emulsifiers preparation
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：By tristearin in 70 DEG C of waters bath with thermostatic control Sour 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating Melt and stir as oil phase；Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g are taken in 70 DEG C of waters bath with thermostatic control Add in 100ml beakers and be heated to 70 DEG C and be well mixed to be used as aqueous phase；1g Losartan Potassiums are weighed with electronic balance, 3g onions carry Thing, 3g triamcinolone acetonide acetates and 3g liquaemins are taken, Losartan Potassium adds aqueous phase dissolved, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver Plain sodium adds oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators. Above method obtains 10% compound ACE classes medicine (liquaemin of+3% Bulbus Allii Cepae extract of 1%ARB+3% triamcinolone acetonide acetates+3%) Containing the anti-scar ointment of numerous emulsifiers.
Can be with by the ratio for changing Losartan Potassium, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases The compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 20 3% (Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+0.5%+ 0.5% liquaemin) anti-scar normal saline solution preparation
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：Under room temperature condition, 100g physiology salts are weighed The aqueous solution, weigh 1g Valsartans, 1g Bulbus Allii Cepae extracts, 0.5g triamcinolone acetonide acetates and 0.5g liquaemins with electronic balance and add life It is sufficiently stirred in reason salt solution.Encapsulation preserves.Above method obtains 3% compound ACE classes medicine (1%ARB+1% triamcinolone acetonide acetates The liquaemin of+0.5% Bulbus Allii Cepae extract+0.5%) anti-scar normal saline solution.
It can be obtained by changing physiological saline and Valsartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract quality proportioning To compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar physiology of 0.05-25% concentration Saline solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 3%ARB+3% triamcinolone acetonide acetates+3% of embodiment 21 10% Plain sodium) anti-scar gel preparation
By taking Irbesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：Under room temperature condition, 72g physiology is weighed Saline solution, add 3g Irbesartans, 1g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates and 3g liquaemins and fully dissolve, add 3g sodium carboxymethylcelluloses, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With top Method obtains 10% compound ACE classes medicine (liquaemin of+1 Bulbus Allii Cepae extract of 3%ARB+3% triamcinolone acetonide acetates+3%) anti-scar and coagulated Glue.
By changing physiological saline and Irbesartan, triamcinolone acetonide acetate, liquaemin and the quality proportioning of Bulbus Allii Cepae extract It can obtain compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar of 0.05-25% concentration Gel, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1% of embodiment 22 4% Plain sodium) anti-scar plastics preparation method
By taking Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：Weigh 8g polyvinyl alcohol (PVA) addition Into 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirring is equal to mixing It is even.1g Telmisartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins are eventually adding, is stirred well to completely molten Solution, is cooled to room temperature.Encapsulation preserves.
Matched somebody with somebody by the quality for changing plastics matrix and Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract Than compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration Trace plastics, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 2%ARB+3% triamcinolone acetonide acetates+2% of embodiment 23 9% Plain sodium) anti-scar bar cloth patch preparation method
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：In 50 DEG C of waters bath with thermostatic control, 2g chlorine is taken Husky smooth potassium, 2g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates and 2g liquaemins, are dissolved in 80g distilled water, are added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added Into 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room Temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 9% compound ACE classes medicine (2%ARB+3% acetic acid The liquaemin of the Bulbus Allii Cepae extract of Triamcinolone acetonide+2%+2%) anti-scar bar cloth patch.
The quality that matrix and Losartan Potassium, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract are pasted by changing bar cloth is matched somebody with somebody Than compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration Trace bar cloth pastes, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1% of embodiment 24 5% Plain sodium) anti-scar spray preparation method
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：In 100g physiological saline, 2g figured silk fabrics is added Sha Tan, 1g Bulbus Allii Cepae extract, 1g triamcinolone acetonide acetates and 1g liquaemins and 1g urea, are stirred.And load spray bottle In.
By changing spray reclaimed water and Valsartan, triamcinolone acetonide acetate, liquaemin and the quality proportioning of Bulbus Allii Cepae extract It can obtain compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar of 0.05-25% concentration Spray, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1% of embodiment 25 6% The plain asiaticosid of sodium+1%) the anti-scar ointment containing urea preparation
By taking smooth potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid for rice as an example：In 70 DEG C of waters bath with thermostatic control Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil Phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts Aqueous phase；1g, which is weighed, with electronic balance replaces the smooth potassium of rice, 2g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g liquaemins and 1g centellas Glycosides, aqueous phase dissolved is added for the smooth potassium of rice, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving； Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.It is multiple that above method obtains 6% Square ACE classes medicine (asiaticosid of+1% liquaemin of+2% Bulbus Allii Cepae extract of 1%ARB+1% triamcinolone acetonide acetates+1%) contains urea Anti- scar ointment.
By changing Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases Ratio can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% mass fractions Sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine (liver of+3% Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1% of embodiment 26 8% The plain asiaticosid of sodium+1%) the anti-scar ointment containing urea preparation
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：In 70 DEG C of waters bath with thermostatic control Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil Phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts Aqueous phase；2g Losartan Potassiums, 3g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetate 1g asiaticosids and 1g heparin are weighed with electronic balance Sodium, Losartan Potassium add aqueous phase dissolved, and triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving； The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains To the 8% compound ACE classes medicine (centella of+1% liquaemin of+3% Bulbus Allii Cepae extract of 2%ARB+1% triamcinolone acetonide acetates+1% Glycosides) the anti-scar ointment containing urea.
By changing Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases Ratio can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% mass fractions Sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine (onion of+0.1% triamcinolone acetonide acetate of 0.1% Losartan Potassium+0.1% of embodiment 27 0.5% The asiaticosid of the liquaemin of extract+0.1%+0.1%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：In 70 DEG C of waters bath with thermostatic control It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml Beaker, heating and melting simultaneously stir as oil phase；Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；100mg chlorine sand is weighed with electronic balance Smooth potassium, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates, 100mg asiaticosids and 100mg liquaemins, Losartan Potassium add Enter aqueous phase dissolved, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving；Finally by aqueous phase oil Mix and be sufficiently stirred and be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE class medicines (asiaticosid of+0.1% liquaemin of 0.1% Losartan Potassium+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) contains The anti-scar ointment of numerous emulsifiers.
By changing Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases Ratio can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% mass fractions Sodium+asiaticosid) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 28 0.5% (extract by the onion of 0.1%ARB+0.2% triamcinolone acetonide acetates+0.1% The asiaticosid of the liquaemin of thing+0.05%+0.05%) anti-scar normal saline solution preparation
By taking Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：Under room temperature condition, claim 100g normal saline solutions are taken, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts, 200mg acetic acid Qu An are weighed with electronic balance Nai De, 50mg asiaticosid and 50mg liquaemins, which are added in physiological saline, to be sufficiently stirred.Encapsulation preserves.Above method obtains 0.5% compound ACE classes medicine (liquaemin of+0.1% Bulbus Allii Cepae extract of 0.1%ARB+0.2% triamcinolone acetonide acetates+0.05%+ 0.05% asiaticosid) anti-scar normal saline solution.
By changing physiological saline and Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid matter Amount proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin+ Asiaticosid) anti-scar normal saline solution, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 2%ARB+2% triamcinolone acetonide acetates+2% of embodiment 29 10% The plain asiaticosid of sodium+2%) anti-scar gel preparation
By taking Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：Under room temperature condition, weigh 72g normal saline solutions, add 2g Valsartans, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins Fully dissolving, 3g sodium carboxymethylcelluloses are added, are swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fat Sour sorb is smooth.Above method obtain 10% compound ACE classes medicine (Bulbus Allii Cepae extract of 2%ARB+2% triamcinolone acetonide acetates+2%+ The asiaticosid of 2% liquaemin+2%) anti-scar gel.
By changing physiological saline and Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and the matter of asiaticosid Amount proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin+ Asiaticosid) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 6%ARB+2% triamcinolone acetonide acetates+2% of embodiment 30 14% The plain asiaticosid of sodium+2%) anti-scar plastics preparation method
By taking Telmisartan as an example：Weigh 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, in 90 DEG C of waters bath with thermostatic control It is stirred well to and is completely dissolved, add 3ml glycerine, stirs to well mixed.It is eventually adding 6g Telmisartans, the extraction of 2g onions Thing, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation is protected Deposit.
By changing plastics matrix and Telmisartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid Quality proportioning can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% concentration Sodium+asiaticosid) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract+0.5% of 3%ARB+2% triamcinolone acetonide acetates+3% of embodiment 31 9% The asiaticosid of liquaemin+0.5%) anti-scar bar cloth patch preparation method
By taking Candesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：In 50 DEG C of waters bath with thermostatic control In, the smooth potassium of 3g candys, 3g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 500mg asiaticosids and 500mg liquaemins are taken, is dissolved in In 80g distilled water, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, Obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed simultaneously It is stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 9% Compound ACE classes medicine (asiaticosid of+0.5% liquaemin of+3% Bulbus Allii Cepae extract of 3%ARB+2% triamcinolone acetonide acetates+0.5%) Anti- scar bar cloth patch.
Matrix and the smooth potassium of candy, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid are pasted by changing bar cloth Quality proportioning can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% concentration Sodium+asiaticosid) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 2%ARB+3% triamcinolone acetonide acetates+1% of embodiment 32 8% The plain asiaticosid of sodium+1%) anti-scar spray preparation method
By taking Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：In 100g physiological saline In, 2g Telmisartans, 1g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins and 1g urea are added, is filled Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and for the smooth potassium of rice, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid Quality proportioning can obtain compound ACE classes medicine (the ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% concentration Sodium+asiaticosid) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
Embodiment 33 0.05% compound ACE classes medicine (0.02%ACEI+0.03% triamcinolone acetonide acetates) anti-scar containing urea The preparation of trace ointment
By taking Ramipril+triamcinolone acetonide acetate as an example：By magnesium stearate 8.5g, white oil in 70 DEG C of waters bath with thermostatic control 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；Distilled water is taken in 70 DEG C of waters bath with thermostatic control 32mL is added in 100ml beakers and is heated to 70 DEG C, is added urea 10g dissolvings and is used as aqueous phase；20mg thunders are weighed with electronic balance Meter Pu Li and 30mg triamcinolone acetonide acetates, Ramipril, triamcinolone acetonide acetate add oil phase dissolving；Finally aqueous phase oil phase is mixed And be sufficiently stirred and be cooled to room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 0.05% compound ACE class medicines (0.02%ACEI+0.03% triamcinolone acetonide acetates) anti-scar ointment containing urea.
Ratio by changing Ramipril, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point Several compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
Embodiment 34 0.3% compound ACE classes medicine (0.2%ACEI+0.1% triamcinolone acetonide acetates) anti-scar containing urea The preparation of ointment
By taking enalapril+triamcinolone acetonide acetate as an example：By magnesium stearate 8.5g, white oil in 70 DEG C of waters bath with thermostatic control 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；Distilled water is taken in 70 DEG C of waters bath with thermostatic control 32mL is added in 100ml beakers and is heated to 70 DEG C, is added urea 10g dissolvings and is used as aqueous phase；With electronic balance weigh 200m according to That Puli and 100mg triamcinolone acetonide acetates, enalapril, triamcinolone acetonide acetate add oil phase dissolving；The mixing of water oil phase is fully stirred Mix and add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 0.3% compound ACE classes Medicine (0.2%ACEI+0.1% triamcinolone acetonide acetates) anti-scar ointment containing urea.
Ratio by changing enalapril, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point Several compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar ointment containing urea.
The compound ACE classes medicine (0.9%ACEI+0.3% triamcinolone acetonide acetates) of embodiment 35 1.2% contains numerous emulsifiers The preparation of anti-scar ointment
By taking captopril+triamcinolone acetonide acetate as an example：By stearic acid 4.8g, octadecyl alcolol 4g, list in 70 DEG C of waters bath with thermostatic control Tristerin 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating and melting and the conduct that stirs Oil phase；Take distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to add Heat is to 70 DEG C and well mixed is used as aqueous phase；900mg captoprils and 300mg triamcinolone acetonide acetates are weighed with electronic balance, is blocked Top's profit, triamcinolone acetonide acetate add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, sealing is protected It is stored in 5 DEG C of refrigerators.Above method obtains 1.2% compound ACE classes medicine (0.9%ACEI+0.3% triamcinolone acetonide acetates) containing more The kind anti-scar ointment of emulsifying agent.
Ratio by changing captopril, triamcinolone acetonide acetate and ointment bases can obtain 0.05-25% mass point Several compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar ointment containing numerous emulsifiers.
Embodiment 36 5% compound ACE classes medicine (3%ACEI+2% triamcinolone acetonide acetates) anti-scar normal saline solution Preparation
By taking Ramipril+triamcinolone acetonide acetate as an example：Under room temperature condition, 100g normal saline solutions are weighed, with electronics day Flat weigh is sufficiently stirred in 3g Ramiprils and 2g triamcinolone acetonide acetates addition physiological saline.Encapsulation preserves.Above method obtains 5% compound ACE classes medicine (triamcinolone acetonide acetate of 3% Ramipril+2%) anti-scar normal saline solution.
0.05-25% concentration is can obtain by changing physiological saline and Ramipril, triamcinolone acetonide acetate quality proportioning Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar normal saline solution, with for different type scar or obtain most Good anti-scar effect.
The preparation of embodiment 37 10% compound ACE classes medicine (5%ACEI+5% triamcinolone acetonide acetates) anti-scar gel
By taking enalapril+triamcinolone acetonide acetate as an example：Under room temperature condition, 72g normal saline solutions are weighed, add 5g according to that Puli and 5g triamcinolone acetonide acetates fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C.Finally plus Enter 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 10% compound ACE classes medicine, and (5%ACEI+5% acetic acid is bent An Naide) anti-scar gel.
0.05-25% concentration is can obtain by changing physiological saline and enalapril, the quality proportioning of triamcinolone acetonide acetate Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar gel, for different type scar or to obtain optimal anti-scar Trace effect.
It is prepared by the anti-scar plastics of the compound ACE classes medicine (5%ACEI+10% triamcinolone acetonide acetates) of embodiment 38 15% Method
By taking lisinopril+triamcinolone acetonide acetate as an example：8g polyvinyl alcohol (PVA) is weighed to be added in 88ml distilled water, It is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.It is eventually adding 5g and relies promise Puli and 10g triamcinolone acetonide acetates, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and lisinopril, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar plastics of degree, with optimal for different type scar or acquirement Anti- scar effect.
The anti-scar bar cloth patch of the compound ACE classes medicine (0.1%ACEI+0.2% triamcinolone acetonide acetates) of embodiment 39 0.3% Preparation method
By taking Ramipril+triamcinolone acetonide acetate as an example：In 50 DEG C of waters bath with thermostatic control, 100mg Ramiprils and 200mg vinegar are taken Sour Triamcinolone acetonide, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With Upper method obtains the anti-scar bar cloth patch of 0.3% compound ACE classes medicine (0.1%ACEI+0.2% triamcinolone acetonide acetates).
By changing, bar cloth pastes matrix and a Ramipril, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense The anti-scar bar cloth patch of compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) of degree, with optimal for different type scar or acquirement Anti- scar effect.
Embodiment 40 0.8% compound ACE classes medicine (0.2%ACEI+0.6% triamcinolone acetonide acetates) anti-scar spray Preparation method
By taking enalapril+triamcinolone acetonide acetate as an example：In 100g physiological saline, 200mg enalaprils and 600mg are added Triamcinolone acetonide acetate and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and enalapril, that the quality proportioning of triamcinolone acetonide acetate can obtain 0.05-25% is dense Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates) anti-scar spray of degree, with optimal for different type scar or acquirement Anti- scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ACEI+1% triamcinolone acetonide acetates+1%) of embodiment 41 3% is containing urine The preparation of the anti-scar ointment of element
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：By magnesium stearate in 70 DEG C of waters bath with thermostatic control 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70 DEG C of thermostatted waters Take distilled water 32mL to add in 100ml beakers in bath and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；With electronics day It is flat to weigh 1g captoprils, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, captopril, triamcinolone acetonide acetate, onion extraction Thing adds oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.With Upper method obtains 3% compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ACEI+1% triamcinolone acetonide acetates+1%) anti-scar containing urea Ointment.
It can be obtained by the ratio for changing captopril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar containing urea of 0.05-25% mass fractions is soft Cream.
The compound ACE classes medicine of embodiment 42 1% (extract by the onion of 0.3%ACEI+0.5% triamcinolone acetonide acetates+0.2% Thing) the anti-scar ointment containing urea preparation
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：By magnesium stearate in 70 DEG C of waters bath with thermostatic control 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70 DEG C of thermostatted waters Take distilled water 32mL to add in 100ml beakers in bath and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；With electronics day It is flat to weigh 300mg Ramiprils, 200mg Bulbus Allii Cepae extracts and 500mg triamcinolone acetonide acetates, Ramipril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract adds oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealing is deposited It is stored in 5 DEG C of refrigerators.Above method obtains 1% compound ACE classes medicine (0.3%ACEI+0.5% triamcinolone acetonide acetates+0.2% Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
It can be obtained by the ratio for changing Ramipril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar containing urea of 0.05-25% mass fractions is soft Cream.
The compound ACE classes medicine of embodiment 43 0.5% (extract by the onion of 0.3%ACEI+0.1% triamcinolone acetonide acetates+0.1% Thing) the anti-scar ointment containing numerous emulsifiers preparation
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：In 70 DEG C of waters bath with thermostatic control by stearic acid 4.8g, Octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting is simultaneously Stir as oil phase；Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g is taken to add in 70 DEG C of waters bath with thermostatic control It is heated to 70 DEG C in 100ml beakers and is well mixed to be used as aqueous phase；300mg enalaprils, 100mg onions are weighed with electronic balance Extract and 100mg triamcinolone acetonide acetates, enalapril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving；Finally will Aqueous phase oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE Class medicine (Bulbus Allii Cepae extract of 0.3%ACEI+0.1% triamcinolone acetonide acetates+0.1%) anti-scar ointment containing numerous emulsifiers.
It can be obtained by the ratio for changing enalapril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases The compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% mass fractions resists containing numerous emulsifiers Scar ointment.
Embodiment 44 4% compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ACEI+2% triamcinolone acetonide acetates+1%) anti-scar The preparation of trace normal saline solution
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Under room temperature condition, it is water-soluble to weigh 100g physiology salts Liquid, weighed in 1g captoprils, 1g Bulbus Allii Cepae extracts and 2g triamcinolone acetonide acetates addition physiological saline with electronic balance and fully stirred Mix.Encapsulation preserves.Above method obtains 4% compound ACE classes medicine, and (onion of 1%ACEI+2% triamcinolone acetonide acetates+1% is extracted Thing) anti-scar normal saline solution.
By changing physiological saline and captopril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract quality proportioning can obtain Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar normal saline solution of 0.05-25% concentration, With for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 45 1.1% (extract by the onion of 0.3%ACEI+0.2% triamcinolone acetonide acetates+0.6% Thing) anti-scar gel preparation
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Under room temperature condition, it is water-soluble to weigh 72g physiology salts Liquid, add 300mg Ramiprils, 600mg Bulbus Allii Cepae extracts and 200mg triamcinolone acetonide acetates and fully dissolve, add 3g carboxylic first Base sodium cellulosate, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 1% compound ACE classes medicine (Bulbus Allii Cepae extract of 0.3%ACEI+0.2% triamcinolone acetonide acetates+0.6%) anti-scar gel.
By changing physiological saline and Ramipril, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar gel of 0.05-25% concentration, with for not Same type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 46 0.3% (extract by the onion of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1% Thing) anti-scar plastics preparation method
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Weigh 8g polyvinyl alcohol (PVA) and be added to 88ml In distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.Finally 100mg captoprils, 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates are added, is stirred well to and is completely dissolved, is cooled down To room temperature.Encapsulation preserves.
By changing plastics matrix and captopril, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain Compound ACE classes medicine (captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar plastics of 0.05-25% concentration, with For different type scar or obtain optimal anti-scar effect.
Embodiment 47 15% compound ACE classes medicine (Bulbus Allii Cepae extract of 9%ACEI+3% triamcinolone acetonide acetates+3%) anti-scar Trace bar cloth pastes preparation method
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：In 50 DEG C of waters bath with thermostatic control, take 9g lisinoprils, 3g Bulbus Allii Cepae extracts and 3g triamcinolone acetonide acetates, are dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving is stirred Mix uniformly, obtain B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, Cover adherent layer, stripping and slicing.Above method obtains the 15% compound ACE classes medicine (onion of 9%ACEI+3% triamcinolone acetonide acetates+3% Extract) anti-scar bar cloth patch.
The quality proportioning that matrix and lisinopril, triamcinolone acetonide acetate and Bulbus Allii Cepae extract are pasted by changing bar cloth can obtain The anti-scar bar cloth patch of the compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% concentration, with for Different type scar obtains optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract of 1%ACEI+0.5% triamcinolone acetonide acetates+0.5%) of embodiment 48 2% Anti- scar spray preparation method
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：In 100g physiological saline, 1g Lei meter Pu are added Profit, 500mg Bulbus Allii Cepae extracts and 500mg triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Ramipril, the quality proportioning of triamcinolone acetonide acetate and Bulbus Allii Cepae extract can obtain Compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar spray of 0.05-25% concentration, with for Different type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 49 0.5% (extract by the onion of 0.1%ACEI+0.2% triamcinolone acetonide acetates+0.1% The liquaemin of thing+0.1) the anti-scar ointment containing urea preparation
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：By tristearin in 70 DEG C of waters bath with thermostatic control Sour magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70 DEG C of perseverances Take distilled water 32mL to add in 100ml beakers in tepidarium and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；Electricity consumption Sub- balance weighs 100mg enalaprils, 100mg Bulbus Allii Cepae extracts, 200mg triamcinolone acetonide acetates and 100mg liquaemins, Yi Napu Profit, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred cold But to room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE classes medicine (0.1%ACEI+0.2% vinegar The sour liquaemin of the Bulbus Allii Cepae extract of Triamcinolone acetonide+0.1%+0.1%) the anti-scar ointment containing urea.
Can be with by the ratio for changing enalapril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases The compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 50 3% (Bulbus Allii Cepae extract of 1%ACEI+0.5% triamcinolone acetonide acetates+0.5%+ 1% liquaemin) the anti-scar ointment containing urea preparation
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：By tristearin in 70 DEG C of waters bath with thermostatic control Sour magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70 DEG C of perseverances Take distilled water 32mL to add in 100ml beakers in tepidarium and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；Electricity consumption Sub- balance weighs 1g lisinoprils, 500mg Bulbus Allii Cepae extracts, 500mg triamcinolone acetonide acetates and 1g liquaemins, lisinopril, vinegar Sour Triamcinolone acetonide, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue Stir to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 3% compound ACE classes medicine (1%ACEI+0.5% acetic acid The liquaemin of the Bulbus Allii Cepae extract of Triamcinolone acetonide+0.5%+1%) the anti-scar ointment containing urea.
Can be with by the ratio for changing lisinopril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases The compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 51 0.9% (extract by the onion of 0.1%ACEI+0.2% triamcinolone acetonide acetates+0.3% The liquaemin of thing+0.3%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：By tristearin in 70 DEG C of waters bath with thermostatic control Sour 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating Melt and stir as oil phase；Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g are taken in 70 DEG C of waters bath with thermostatic control Add in 100ml beakers and be heated to 70 DEG C and be well mixed to be used as aqueous phase；100mg Ramiprils, 300mg are weighed with electronic balance Bulbus Allii Cepae extract, 200mg triamcinolone acetonide acetates and 300mg liquaemins, Ramipril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver Plain sodium adds oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators. Above method obtain 0.9% compound ACE classes medicine (Bulbus Allii Cepae extract of 0.1%ACEI+0.2% triamcinolone acetonide acetates+0.3%+ 0.3% liquaemin) the anti-scar ointment containing numerous emulsifiers.
Can be with by the ratio for changing Ramipril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases The compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% mass fractions is obtained containing urine The anti-scar ointment of element.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 1%ACEI+2% triamcinolone acetonide acetates+1% of embodiment 52 5% Plain sodium) anti-scar normal saline solution preparation
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：Under room temperature condition, 100g physiology is weighed Saline solution, weigh 1g captoprils, 1g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 1g liquaemins with electronic balance and add life It is sufficiently stirred in reason salt solution.Encapsulation preserves.Above method obtains 5% compound ACE classes medicine, and (how is 1%ACEI+2% acetic acid Qu An The liquaemin of the Bulbus Allii Cepae extract of moral+1%+1%) anti-scar normal saline solution.
Can by changing physiological saline and captopril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract quality proportioning Obtain the anti-scar life of compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) of 0.05-25% concentration Saline solution is managed, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 2%ACEI+2% triamcinolone acetonide acetates+1% of embodiment 53 7% Plain sodium) anti-scar gel preparation
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：Under room temperature condition, 72g physiology is weighed Saline solution, add 2g enalaprils, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 1g liquaemins and fully dissolve, add 3g sodium carboxymethylcelluloses, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With top Method obtains 7% compound ACE classes medicine (liquaemin of+2% Bulbus Allii Cepae extract of 2%ACEI+2% triamcinolone acetonide acetates+1%) anti-scar Gel.
By changing physiological saline and enalapril, triamcinolone acetonide acetate, liquaemin and the quality proportioning of Bulbus Allii Cepae extract It can obtain compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar of 0.05-25% concentration Gel, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 54 3% (Bulbus Allii Cepae extract of 0.5%ACEI+0.5% triamcinolone acetonide acetates+1%+ 1% liquaemin) anti-scar plastics preparation method
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：Weigh 8g polyvinyl alcohol (PVA) addition Into 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirring is equal to mixing It is even.500mg lisinoprils, 1g Bulbus Allii Cepae extracts, 500mg triamcinolone acetonide acetates and 1g liquaemins are eventually adding, is stirred well to It is completely dissolved, is cooled to room temperature.Encapsulation preserves.
Matched somebody with somebody by the quality for changing plastics matrix and lisinopril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract Than compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration Trace plastics, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 55 0.4% (extract by the onion of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1% The liquaemin of thing+0.1%) anti-scar bar cloth patch preparation method
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：In 50 DEG C of waters bath with thermostatic control, take 100mg enalaprils, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, are dissolved in 80g distilled water, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid；Separately take 4g Sodium Polyacrylates, add in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and is stirred well to mixed Close uniformly, be cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 0.4% compound ACE class medicines The anti-scar bar cloth patch of thing (liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate of 0.1% enalapril+0.1%).
The quality that matrix and enalapril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract are pasted by changing bar cloth is matched somebody with somebody Than compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration Trace bar cloth pastes, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (Bulbus Allii Cepae extract+3% of 1%ACEI+3% triamcinolone acetonide acetates+3% of embodiment 56 10% Liquaemin) anti-scar spray preparation method
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：In 100g physiological saline, 1g is added Ramipril, 3g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates and 3g liquaemins and 1g urea, are stirred.And load spray In mist bottle.
Matched somebody with somebody by the quality for changing spray reclaimed water and Ramipril, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract Than compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) the anti-scar that can obtain 0.05-25% concentration Trace spray, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 57 0.5% (extract by the onion of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1% The asiaticosid of the liquaemin of thing+0.1%+0.1%) the anti-scar ointment containing urea preparation
By taking enalapril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：In 70 DEG C of waters bath with thermostatic control Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil Phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts Aqueous phase；100mg enalaprils, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates, 100mg accumulated snow are weighed with electronic balance Careless glycosides and 100mg liquaemin, it is molten that enalapril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase Solution；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE classes medicine (liquaemin of+0.1% Bulbus Allii Cepae extract of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1%+ 0.1% asiaticosid) the anti-scar ointment containing urea.
By changing enalapril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases Ratio can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% mass fractions Plain sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 1%ACEI+2% triamcinolone acetonide acetates+2% of embodiment 58 7% The plain asiaticosid of sodium+1%) the anti-scar ointment containing urea preparation
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：In 70 DEG C of waters bath with thermostatic control Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil Phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts Aqueous phase；1g captoprils, 1g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 1g asiaticosids and 2g heparin are weighed with electronic balance Sodium, captopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving；The mixing of water oil phase is filled Divide and stir and add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 7% compound ACE Class medicine (asiaticosid of+2% liquaemin of+1% Bulbus Allii Cepae extract of 1%ACEI+2% triamcinolone acetonide acetates+1%) anti-scar containing urea Trace ointment.
By changing captopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases Ratio can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% mass fractions Plain sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine (liver of+1% Bulbus Allii Cepae extract of 1%ACEI+1% triamcinolone acetonide acetates+1% of embodiment 59 5% The plain asiaticosid of sodium+1%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：In 70 DEG C of waters bath with thermostatic control It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml Beaker, heating and melting simultaneously stir as oil phase；Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；1g Lei meter Pu are weighed with electronic balance Profit, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins, Ramipril, triamcinolone acetonide acetate, ocean Herba Alii fistulosi extract, liquaemin and asiaticosid add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, It is sealed in 5 DEG C of refrigerators.Above method obtains 5% compound ACE classes medicine (1%ACEI+1% triamcinolone acetonide acetates+1% The asiaticosid of the liquaemin of Bulbus Allii Cepae extract+1%+1%) the anti-scar ointment containing numerous emulsifiers.
By changing Ramipril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and ointment bases Ratio can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% mass fractions Plain sodium+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 60 4% (Bulbus Allii Cepae extract of 1%ACEI+0.5% triamcinolone acetonide acetates+1%+ The asiaticosid of 0.5% liquaemin+1%) anti-scar normal saline solution preparation
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：Under room temperature condition, claim 100g normal saline solutions are taken, 1g captoprils, 1g Bulbus Allii Cepae extracts, 500mg triamcinolone acetonide acetates, 1g are weighed with electronic balance Asiaticosid and 500mg liquaemins, which are added in physiological saline, to be sufficiently stirred.Encapsulation preserves.Above method obtains 4% compound ACE classes The anti-scar life of medicine (asiaticosid of+0.5% liquaemin of+1% Bulbus Allii Cepae extract of 1%ACEI+0.5% triamcinolone acetonide acetates+1%) Manage saline solution.
By changing physiological saline and captopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid matter Amount proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin+ Asiaticosid) anti-scar normal saline solution, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (liver of+2% Bulbus Allii Cepae extract of 2%ACEI+1% triamcinolone acetonide acetates+2% of embodiment 61 9% The plain asiaticosid of sodium+2%) anti-scar gel preparation
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：Under room temperature condition, claim 72g normal saline solutions are taken, add 2g lisinoprils, 2g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 2g asiaticosids and 2g livers Plain sodium fully dissolves, and adds 3g sodium carboxymethylcelluloses, is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g Fatty acid sorbitan.Above method obtains 9% compound ACE classes medicine, and (onion of 2%ACEI+1% triamcinolone acetonide acetates+2% is extracted The asiaticosid of the liquaemin of thing+2%+2%) anti-scar gel.
By changing physiological saline and lisinopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid Quality proportioning can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+heparin of 0.05-25% concentration Sodium+asiaticosid) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 62 0.5% (extract by the onion of 0.1%ACEI+0.1% triamcinolone acetonide acetates+0.1% The asiaticosid of the liquaemin of thing+0.1%+0.1%) anti-scar plastics preparation method
By taking Ramipril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：Weigh 8g polyvinyl alcohol (PVA) it is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs It is extremely well mixed.It is eventually adding 100mg Ramiprils, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates, 100mg accumulated snow Careless glycosides and 100mg liquaemin, is stirred well to and is completely dissolved, be cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and Ramipril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid Quality proportioning can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% concentration Plain sodium+asiaticosid) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract+2% of 6%ACEI+2% triamcinolone acetonide acetates+4% of embodiment 63 16% The asiaticosid of liquaemin+2%) anti-scar bar cloth patch preparation method
By taking lisinopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：In 50 DEG C of waters bath with thermostatic control In, 6g lisinoprils, 4g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins are taken, is dissolved in 80g distillations In water, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid； 4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and is sufficiently stirred To being well mixed, room temperature is cooled to.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 16% compound ACE Class medicine (asiaticosid of+2% liquaemin of+4% Bulbus Allii Cepae extract of 6%ACEI+2% triamcinolone acetonide acetates+2%) anti-scar bar cloth Patch.
Matrix and lisinopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid are pasted by changing bar cloth Quality proportioning can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% concentration Plain sodium+asiaticosid) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract+2% of 2%ACEI+2% triamcinolone acetonide acetates+2% of embodiment 64 10% The asiaticosid of liquaemin+2%) anti-scar spray preparation method
By taking captopril+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：In 100g physiological saline In, 2g captoprils, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins and 1g urea are added, is filled Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and captopril, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid Quality proportioning can obtain compound ACE classes medicine (the ACEI+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% concentration Plain sodium+asiaticosid) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
Embodiment 65 6% compound ACE classes medicine (2%ACEI+2%ARB+2% triamcinolone acetonide acetates) anti-scar containing urea The preparation of ointment
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate as an example：In 70 DEG C of waters bath with thermostatic control by magnesium stearate 8.5g, White oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；In 70 DEG C of waters bath with thermostatic control Take distilled water 32mL to add in 100ml beakers and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；Claimed with electronic balance 2g Ramiprils, 2g Losartan Potassiums and 2g triamcinolone acetonide acetates are taken, Ramipril, Losartan Potassium, triamcinolone acetonide acetate add oil Phased soln；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains To 6% compound ACE classes medicine (2%ACEI+2%ARB+2% triamcinolone acetonide acetates) anti-scar ointment containing urea.
0.05- can be obtained by the ratio for changing Ramipril, Losartan Potassium, triamcinolone acetonide acetate and ointment bases Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea of 25% mass fraction.
The compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates) of embodiment 66 0.3% is containing urine The preparation of the anti-scar ointment of element
By taking lisinopril+Losartan Potassium+triamcinolone acetonide acetate as an example：In 70 DEG C of waters bath with thermostatic control by magnesium stearate 8.5g, White oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；In 70 DEG C of waters bath with thermostatic control Take distilled water 32mL to add in 100ml beakers and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；Claimed with electronic balance 100mg lisinoprils, 100mg Losartan Potassiums and 100mg triamcinolone acetonide acetates are taken, how are lisinopril, Losartan Potassium, acetic acid Qu An Moral adds oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of ice In case.Above method obtains 0.3% compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates) containing urine The anti-scar ointment of element.
0.05- can be obtained by the ratio for changing lisinopril, Losartan Potassium, triamcinolone acetonide acetate and ointment bases Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar ointment containing urea of 25% mass fraction.
The compound ACE classes medicine (0.3%ACEI+0.3%ARB+0.9% triamcinolone acetonide acetates) of embodiment 67 1.5% is containing more The preparation of the kind anti-scar ointment of emulsifying agent
By taking Ramipril+Valsartan+triamcinolone acetonide acetate as an example：By stearic acid 4.8g, 18 in 70 DEG C of waters bath with thermostatic control Alcohol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting simultaneously stirs Uniformly it is used as oil phase；Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g is taken to add 100ml in 70 DEG C of waters bath with thermostatic control It is heated to 70 DEG C in beaker and is well mixed to be used as aqueous phase；With electronic balance weigh 300mg Ramiprils, 300mg Valsartans and 900mg triamcinolone acetonide acetates, Ramipril, Valsartan, triamcinolone acetonide acetate add oil phase dissolving；Finally aqueous phase oil phase is mixed And be sufficiently stirred and be cooled to room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 1.5% compound ACE classes medicine (0.3% ACEI+0.3%ARB+0.9% triamcinolone acetonide acetates) the anti-scar ointment containing numerous emulsifiers.
0.05-25% can be obtained by the ratio for changing Ramipril, Valsartan, triamcinolone acetonide acetate and ointment bases Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar ointment containing numerous emulsifiers of mass fraction.
Embodiment 68 5% compound ACE classes medicine (3%ACEI+1%ARB+1% triamcinolone acetonide acetates) anti-scar physiology salt The preparation of the aqueous solution
By lisinopril+replace the smooth potassium+triamcinolone acetonide acetate of rice exemplified by：Under room temperature condition, 100g normal saline solutions are weighed, Weighed in 3g lisinoprils, 1g Telmisartans and 1g triamcinolone acetonide acetates addition physiological saline and be sufficiently stirred with electronic balance.Envelope Dress preserves.Above method obtains 5% compound ACE classes medicine (3%ACEI+1%ARB+1% triamcinolone acetonide acetates) anti-scar physiology Saline solution.
By changing physiological saline and lisinopril, can obtain 0.05- for the smooth potassium of rice, triamcinolone acetonide acetate quality proportioning Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar normal saline solution of 25% concentration, with for inhomogeneity Type scar obtains optimal anti-scar effect.
Embodiment 69 0.3% compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates) anti-scar The preparation of trace gel
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate as an example：Under room temperature condition, 72g normal saline solutions are weighed, Add 100mg Ramiprils, 100mg Losartan Potassiums and 100mg triamcinolone acetonide acetates fully to dissolve, add 3g carboxymethyl celluloses Plain sodium, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 0.3% Compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates) anti-scar gel.
By change physiological saline and Ramipril, Losartan Potassium, triamcinolone acetonide acetate quality proportioning can obtain 0.05- Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar gel of 25% concentration, with for different type scar or Obtain optimal anti-scar effect.
Embodiment 70 5% compound ACE classes medicine (3%ACEI+1%ARB+1% triamcinolone acetonide acetates) anti-scar plastics Preparation method
By taking lisinopril+Candesartan+triamcinolone acetonide acetate as an example：Weigh 8g polyvinyl alcohol (PVA) and be added to 88ml steamings In distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.Finally plus Enter 3g lisinoprils, 1g Candesartans and 1g triamcinolone acetonide acetates, be stirred well to and be completely dissolved, be cooled to room temperature.Encapsulation is protected Deposit.
By change plastics matrix and lisinopril, Candesartan, triamcinolone acetonide acetate quality proportioning can obtain Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar plastics of 0.05-25% concentration, with for inhomogeneity Type scar obtains optimal anti-scar effect.
Embodiment 71 11% compound ACE classes medicine (6%ACEI+2%ARB+3% triamcinolone acetonide acetates) anti-scar bar cloth Paste preparation method
By taking captopril+Telmisartan+triamcinolone acetonide acetate as an example：In 50 DEG C of waters bath with thermostatic control, 6g ACEI, 2g are taken ARB and 3g triamcinolone acetonide acetates, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gum, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains To B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covering is anti-sticking Layer, stripping and slicing.Above method obtains 11% compound ACE classes medicine (6%ACEI+2%ARB+3% triamcinolone acetonide acetates) anti-scar bar Cloth pastes.
By change bar cloth paste matrix and captopril, Telmisartan, triamcinolone acetonide acetate quality proportioning can obtain The anti-scar bar cloth patch of compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) of 0.05-25% concentration, with for inhomogeneity Type scar obtains optimal anti-scar effect.
Embodiment 72 6% compound ACE classes medicine (1%ACEI+2%ARB+3% triamcinolone acetonide acetates) anti-scar spray Preparation method
By taking lisinopril+Telmisartan+triamcinolone acetonide acetate as an example：In 100g physiological saline, addition 1g lisinoprils, 2g Telmisartans and 3g triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and lisinopril, Telmisartan, triamcinolone acetonide acetate quality proportioning can obtain Compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates) anti-scar spray of 0.05-25% concentration, with for inhomogeneity Type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 73 0.4% (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates+ 0.1% Bulbus Allii Cepae extract) the anti-scar ointment containing urea preparation
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Will be hard in 70 DEG C of waters bath with thermostatic control Fatty acid magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70℃ Take distilled water 32mL to add in 100ml beakers in water bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；With Electronic balance weighs 100mg Ramiprils, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates, thunder Meter Pu Li, Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving；Finally aqueous phase oil phase is mixed and abundant Stirring is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.4% compound ACE class medicines (0.1%ACEI+ The Bulbus Allii Cepae extract of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1%) the anti-scar ointment containing urea.
Can by the ratio for changing Ramipril, Losartan Potassium, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases To obtain the compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% mass fractions containing urine The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 74 5% (extract by the onion of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1% Thing) the anti-scar ointment containing urea preparation
By taking enalapril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Will be hard in 70 DEG C of waters bath with thermostatic control Fatty acid magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70℃ Take distilled water 32mL to add in 100ml beakers in water bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；With Electronic balance weighs 2g enalaprils, 1g Losartan Potassiums, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, and enalapril, chlorine are husky Smooth potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue Stir to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 5% compound ACE class medicines (2%ACEI+1%ARB+ The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) the anti-scar ointment containing urea.
Can by the ratio for changing enalapril, Losartan Potassium, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases To obtain the compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% mass fractions containing urine The anti-scar ointment of element.
The compound ACE classes medicine of embodiment 75 0.6% (0.1%ACEI+0.1%ARB+0.2% triamcinolone acetonide acetates+ 0.2% Bulbus Allii Cepae extract) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：By tristearin in 70 DEG C of waters bath with thermostatic control Sour 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, heating Melt and stir as oil phase；Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g are taken in 70 DEG C of waters bath with thermostatic control Add in 100ml beakers and be heated to 70 DEG C and be well mixed to be used as aqueous phase；100mg Ramiprils, 100mg are weighed with electronic balance Valsartan, 200mg Bulbus Allii Cepae extracts and 200mg triamcinolone acetonide acetates, Ramipril, Valsartan, triamcinolone acetonide acetate, onion carry Thing is taken to add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators. Above method obtains the 0.6% compound ACE classes medicine (onion of 0.1%ACEI+0.1%ARB+0.2% triamcinolone acetonide acetates+0.2% Extract) the anti-scar ointment containing numerous emulsifiers.
Can be with by the ratio for changing Ramipril, Valsartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract and ointment bases The compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% mass fractions is obtained containing a variety of The anti-scar ointment of emulsifying agent.
The compound ACE classes medicine of embodiment 76 8% (extract by the onion of 2%ACEI+3%ARB+1% triamcinolone acetonide acetates+2% Thing) anti-scar normal saline solution preparation
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Under room temperature condition, 100g lifes are weighed Saline solution is managed, 2g enalaprils, 3g Telmisartans, 2g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates is weighed with electronic balance and adds Enter in physiological saline and be sufficiently stirred.Encapsulation preserves.Above method obtains 8% compound ACE class medicines (2%ACEI+3%ARB+1% The Bulbus Allii Cepae extract of triamcinolone acetonide acetate+2%) anti-scar normal saline solution.
By changing physiological saline and enalapril, Telmisartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract quality proportioning It can obtain the anti-scar life of compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) of 0.05-25% concentration Saline solution is managed, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 77 5% (extract by the onion of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1% Thing) anti-scar gel preparation
By taking Ramipril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Under room temperature condition, 72g lifes are weighed Saline solution is managed, 2g Ramiprils, 1g Telmisartans, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates is added and fully dissolves, then 3g sodium carboxymethylcelluloses are added, are swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With Upper method obtains 5% compound ACE classes medicine (Bulbus Allii Cepae extract of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1%) anti-scar Trace gel.
Matched somebody with somebody by the quality for changing physiological saline and Ramipril, Telmisartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract Than compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) the anti-scar that can obtain 0.05-25% concentration Gel, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 78 9% (extract by the onion of 3%ACEI+3%ARB+2% triamcinolone acetonide acetates+1% Thing) anti-scar plastics preparation method
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：8g polyvinyl alcohol (PVA) is weighed to add Enter into 88ml distilled water, be stirred well to and be completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirring to mixing Uniformly.3g enalaprils, 3g Telmisartans, 1g Bulbus Allii Cepae extracts and 2g triamcinolone acetonide acetates are eventually adding, has been stirred well to Fully dissolved, it is cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and enalapril, Telmisartan, triamcinolone acetonide acetate and the quality of Bulbus Allii Cepae extract Proportioning can obtain compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar of 0.05-25% concentration Trace plastics, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 79 7% (extract by the onion of 3%ACEI+2%ARB+1% triamcinolone acetonide acetates+1% Thing) anti-scar bar cloth patch preparation method
By taking lisinopril+Candesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：In 50 DEG C of waters bath with thermostatic control, 3g is taken Lisinopril, 2g Candesartans, 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, are dissolved in 80g distilled water, add into the aqueous solution Enter 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, Add in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to Room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 7% compound ACE class medicines (3%ACEI+2% The Bulbus Allii Cepae extract of ARB+1% triamcinolone acetonide acetates+1%) anti-scar bar cloth patch.
The quality of matrix and lisinopril, Candesartan, triamcinolone acetonide acetate and Bulbus Allii Cepae extract is pasted by changing bar cloth Proportioning can obtain compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar of 0.05-25% concentration Trace bar cloth pastes, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 80 0.4% (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates+ 0.1% Bulbus Allii Cepae extract) anti-scar spray preparation method
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：In 100g physiological saline, add 100mg Ramiprils, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates and 1g urea, are fully stirred Mix uniformly.And it is fitted into spray bottle.
By changing spray reclaimed water and Ramipril, Losartan Potassium, triamcinolone acetonide acetate and the quality of Bulbus Allii Cepae extract Proportioning can obtain compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract) anti-scar of 0.05-25% concentration Trace spray, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 81 6% (extract by the onion of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1% The liquaemin of thing+1%) the anti-scar ointment containing urea preparation
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：In 70 DEG C of waters bath with thermostatic control Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil Phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts Aqueous phase；2g enalaprils, 1g Telmisartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g heparin are weighed with electronic balance Sodium, enalapril, Telmisartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；Finally by aqueous phase oil Mix and be sufficiently stirred and be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 6% compound ACE class medicines (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liquaemin) anti-scar ointment containing urea.
By changing enalapril, Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases Ratio can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract of 0.05-25% mass fractions + liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 82 9% (extract by the onion of 3%ACEI+1%ARB+1% triamcinolone acetonide acetates+3% The liquaemin of thing+1%) the anti-scar ointment containing urea preparation
By taking lisinopril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：In 70 DEG C of waters bath with thermostatic control Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil phase； Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings and be used as water Phase；3g lisinoprils, 1g Valsartans, 3g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins are weighed with electronic balance, is relied Promise Puli, Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；The mixing of water oil phase is sufficiently stirred simultaneously Add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 9% compound ACE class medicines (liquaemin of+3% Bulbus Allii Cepae extract of 3%ACEI+1%ARB+1% triamcinolone acetonide acetates+1%) anti-scar ointment containing urea.
By the ratio for changing lisinopril, Valsartan, triamcinolone acetonide acetate, liquaemin, Bulbus Allii Cepae extract and ointment bases Example can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+ Liquaemin) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 83 0.5% (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates+ The liquaemin of 0.1% Bulbus Allii Cepae extract+0.1%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：In 70 DEG C of waters bath with thermostatic control It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml Beaker, heating and melting simultaneously stir as oil phase；Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；100mg thunder rice is weighed with electronic balance Puli, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, Ramipril, chlorine Husky smooth potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；Finally aqueous phase oil phase is mixed and fully stirred Mix and be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE class medicines (0.1%ACEI+ The liquaemin of+0.1% Bulbus Allii Cepae extract of 0.1%ARB+0.1% triamcinolone acetonide acetates+0.1%) the anti-scar containing numerous emulsifiers is soft Cream.
By changing Ramipril, Losartan Potassium, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract and ointment bases Ratio can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract of 0.05-25% mass fractions + liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 84 10% (extract by the onion of 2%ACEI+2%ARB+2% triamcinolone acetonide acetates+2% The liquaemin of thing+2%) anti-scar normal saline solution preparation
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：Under room temperature condition, claim 100g normal saline solutions are taken, it is bent to weigh 2g enalaprils, 2g Telmisartans, 2g Bulbus Allii Cepae extracts, 2g acetic acid with electronic balance An Naide and 2g liquaemins are added in physiological saline and are sufficiently stirred.Encapsulation preserves.Above method obtains 10% compound ACE class medicines (liquaemin of+2% Bulbus Allii Cepae extract of 2%ACEI+2%ARB+2% triamcinolone acetonide acetates+2%) anti-scar normal saline solution.
By changing physiological saline and enalapril, Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract matter Amount proportioning can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+liver of 0.05-25% concentration Plain sodium) anti-scar normal saline solution, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 85 6% (extract by the onion of 2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1% The liquaemin of thing+1%) anti-scar gel preparation
By taking lisinopril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：Under room temperature condition, claim 72g normal saline solutions are taken, add 2g lisinoprils, 1g Telmisartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g livers Plain sodium fully dissolves, and adds 3g sodium carboxymethylcelluloses, is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g Fatty acid sorbitan.Above method obtains 6% compound ACE classes medicine (2%ACEI+1%ARB+1% triamcinolone acetonide acetates+1% The liquaemin of Bulbus Allii Cepae extract+1%) anti-scar gel.
By changing physiological saline and lisinopril, Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract Quality proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+ Liquaemin) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 86 20% (extract by the onion of 4%ACEI+4%ARB+4% triamcinolone acetonide acetates+4% The liquaemin of thing+4%) anti-scar plastics preparation method
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：Weigh 8g polyvinyl alcohol (PVA) it is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs It is extremely well mixed.It is eventually adding 4g enalaprils, 4g Telmisartans, 4g Bulbus Allii Cepae extracts, 4g triamcinolone acetonide acetates and 4g heparin Sodium, it is stirred well to and is completely dissolved, is cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and enalapril, Telmisartan, triamcinolone acetonide acetate, liquaemin and Bulbus Allii Cepae extract Quality proportioning can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract of 0.05-25% concentration + liquaemin) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 87 8% (extract by the onion of 1%ACEI+2%ARB+2% triamcinolone acetonide acetates+2% The liquaemin of thing+1%) anti-scar bar cloth patch preparation method
By taking Ramipril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：In 50 DEG C of waters bath with thermostatic control In, 1g Ramiprils, 2g Valsartans, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 1g liquaemins are taken, is dissolved in 80g distilled water In, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid；Separately 4g Sodium Polyacrylates are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and is stirred well to It is well mixed, it is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 8% compound ACE class medicines The anti-scar bar cloth patch of thing (liquaemin of+2% Bulbus Allii Cepae extract of 1%ACEI+2%ARB+2% triamcinolone acetonide acetates+1%).
Matrix and Ramipril, Valsartan, triamcinolone acetonide acetate, liquaemin, Bulbus Allii Cepae extract are pasted by changing bar cloth Quality proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract+ Liquaemin) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 88 7% (extract by the onion of 2%ACEI+2%ARB+1% triamcinolone acetonide acetates+1% The liquaemin of thing+1%) anti-scar spray preparation method
By taking lisinopril+Candesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as an example：In 100g physiological saline In, 2g lisinoprils, 2g Candesartans, 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins and 1g urea are added, is filled Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and lisinopril, Candesartan, triamcinolone acetonide acetate, liquaemin, Bulbus Allii Cepae extract Quality proportioning can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+Bulbus Allii Cepae extract of 0.05-25% concentration + liquaemin) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 89 0.6% (0.1%ACEI+0.1%ARB+0.1% triamcinolone acetonide acetates+ The asiaticosid of+0.1% liquaemin of 0.1% Bulbus Allii Cepae extract+0.1%) the anti-scar ointment containing urea preparation
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：70 Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs Uniformly it is used as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings are used as aqueous phase；With electronic balance weigh 100mg Ramiprils, 100mg Losartan Potassiums, 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetate 100mg asiaticosids and 100mg liquaemins, Ramipril, Losartan Potassium, triamcinolone acetonide acetate, ocean Herba Alii fistulosi extract, liquaemin and asiaticosid add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, It is sealed in 5 DEG C of refrigerators.Above method obtains 0.6% compound ACE classes medicine (0.1%ACEI+0.1%ARB+0.1% vinegar The sour asiaticosid of+0.1% liquaemin of the Bulbus Allii Cepae extract of Triamcinolone acetonide+0.1%+0.1%) the anti-scar ointment containing urea.
By change Ramipril, Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+ Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 90 8% (extract by the onion of 1%ACEI+2%ARB+2% triamcinolone acetonide acetates+1% The asiaticosid of the liquaemin of thing+1%+1%) the anti-scar ointment containing urea preparation
By taking enalapril+Telmisartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：70 Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs Uniformly it is used as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings are used as aqueous phase；How 1g enalaprils, 2g Telmisartans, 1g Bulbus Allii Cepae extracts, 2g acetic acid Qu An are weighed with electronic balance Moral 1g asiaticosids and 1g liquaemins, enalapril, Telmisartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and accumulated snow Careless glycosides adds oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C In refrigerator.Above method obtains 8% compound ACE classes medicine, and (onion of 1%ACEI+2%ARB+2% triamcinolone acetonide acetates+1% carries Take the asiaticosid of the liquaemin of thing+1%+1%) the anti-scar ointment containing urea.
By change enalapril, Telmisartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+ Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 91 16% (extract by the onion of 2%ACEI+2%ARB+6% triamcinolone acetonide acetates+2% The asiaticosid of the liquaemin of thing+2%+2%) the anti-scar ointment containing numerous emulsifiers preparation
By taking enalapril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：At 70 DEG C Stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put in water bath with thermostatic control Enter 100ml beakers, heating and melting simultaneously stirs as oil phase；Distilled water 60mL, glycerine 10ml, ten are taken in 70 DEG C of waters bath with thermostatic control Sodium dialkyl sulfate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；2g is weighed with electronic balance Enalapril, 2g Valsartans, 2g Bulbus Allii Cepae extracts, 6g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins, enalapril, Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving；Finally aqueous phase oil phase is mixed Merging, which is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 16% compound ACE classes medicine (2% The asiaticosid of+2% liquaemin of+2% Bulbus Allii Cepae extract of ACEI+2%ARB+6% triamcinolone acetonide acetates+2%) contain numerous emulsifiers Anti- scar ointment.
By changing enalapril, Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid and soft The ratio of cream base matter can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+ocean of 0.05-25% mass fractions Herba Alii fistulosi extract+liquaemin+asiaticosid) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 92 22% (extract by the onion of 6%ACEI+4%ARB+6% triamcinolone acetonide acetates+2% The asiaticosid of the liquaemin of thing+2%+2%) anti-scar normal saline solution preparation
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：Room temperature Under the conditions of, weigh 100g normal saline solutions, with electronic balance weigh 6g Ramiprils, 4g Losartan Potassiums, 2g Bulbus Allii Cepae extracts, 6g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins are added in physiological saline and are sufficiently stirred.Encapsulation preserves.Above method obtains To 22% compound ACE classes medicine (liquaemin of+2% Bulbus Allii Cepae extract of 6%ACEI+4%ARB+6% triamcinolone acetonide acetates+2%+ 2% asiaticosid) anti-scar normal saline solution.
By change physiological saline and Ramipril, Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and Asiaticosid quality proportioning can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+onion of 0.05-25% concentration Extract+liquaemin+asiaticosid) anti-scar normal saline solution, for different type scar or to obtain optimal anti-scar Effect.
The compound ACE classes medicine of embodiment 93 10% (extract by the onion of 2%ACEI+2%ARB+2% triamcinolone acetonide acetates+2% The asiaticosid of the liquaemin of thing+1%+1%) anti-scar gel preparation
By taking lisinopril+Valsartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：Room temperature bar Under part, weigh 72g normal saline solutions, add 2g lisinoprils, 2g Valsartans, 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C.Finally plus Enter 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 10% compound ACE class medicines (2%ACEI+2%ARB+2% The asiaticosid of+1% liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+2%+1%) anti-scar gel.
By changing physiological saline and lisinopril, Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and product The quality proportioning of Asiaticoside can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+onion of 0.05-25% concentration Extract+liquaemin+asiaticosid) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 94 12% (extract by the onion of 2%ACEI+2%ARB+2% triamcinolone acetonide acetates+2% The asiaticosid of the liquaemin of thing+2%+2%) anti-scar plastics preparation method
By taking lisinopril+Valsartan as an example+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid exemplified by：Claim Take 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, be stirred well to and be completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stir to well mixed.How it is eventually adding 2g lisinoprils, 2g Valsartans, 2g Bulbus Allii Cepae extracts, 2g acetic acid Qu An Moral, 2g asiaticosids and 2g liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By change plastics matrix and lisinopril, Valsartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and The quality proportioning of asiaticosid can obtain compound ACE classes medicine (the ACEI+ARB+ triamcinolone acetonide acetates+ocean of 0.05-25% concentration Herba Alii fistulosi extract+liquaemin+asiaticosid) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 95 11% (extract by the onion of 3%ACEI+2%ARB+1% triamcinolone acetonide acetates+2% The asiaticosid of the liquaemin of thing+2%+1%) anti-scar bar cloth patch preparation method
By taking enalapril+Candesartan+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example：50 In DEG C water bath with thermostatic control, take 3g enalaprils, 2g Candesartans, 2g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 2g liquaemins, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With Upper method obtains the 11% compound ACE classes medicine (Bulbus Allii Cepae extract+2% of 3%ACEI+2%ARB+1% triamcinolone acetonide acetates+2% The asiaticosid of liquaemin+1%) anti-scar bar cloth patch.
Matrix and enalapril, Candesartan, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin are pasted by changing bar cloth With the quality proportioning of asiaticosid can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+ Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar and imitate Fruit.
The compound ACE classes medicine of embodiment 96 9% (extract by the onion of 1%ACEI+1%ARB+3% triamcinolone acetonide acetates+2% The asiaticosid of the liquaemin of thing+1%+1%) anti-scar spray preparation method
By taking Ramipril+Losartan Potassium+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid as an example： In 100g physiological saline, 1g Ramiprils, 1g Losartan Potassiums, 2g Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates, 1g centellas are added Glycosides and 1g liquaemins and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Ramipril, Losartan Potassium, triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin With the quality proportioning of asiaticosid can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+ARB+ triamcinolone acetonide acetates+ Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar spray, for different type scar or to obtain optimal anti-scar and imitate Fruit.
The compound ACE classes medicine of embodiment 97 0.4% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE- 140)+0.1% triamcinolone acetonide acetate) the anti-scar ointment containing urea preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 70 DEG C of waters bath with thermostatic control Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil Phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts Aqueous phase；100mg Ramiprils, 100mg L-733060,100mg DALBK (or HOE-140) and 100mg are weighed with electronic balance Triamcinolone acetonide acetate, Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate add oil phase dissolving；Finally Aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.4% compound ACE classes medicine (triamcinolone acetonide acetates of 0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-140)+0.1%) is containing urine The anti-scar ointment of element.
By changing Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases Example can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% mass fractions Sour Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine (1%ACEI+1%L-733060+1%DALBK (or HOE-140)+1% of embodiment 98 4% Triamcinolone acetonide acetate) the anti-scar ointment containing urea preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 70 DEG C of waters bath with thermostatic control Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil Phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts Aqueous phase；How 1g Ramiprils, 1g L-733060,1g DALBK (or HOE-140) and 1g acetic acid Qu An are weighed with electronic balance Moral, Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate add oil phase dissolving；The mixing of water oil phase is abundant Stir and add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 4% compound ACE classes Medicine (triamcinolone acetonide acetates of 1%ACEI+1%L-733060+1%DALBK (or HOE-140)+1%) anti-scar containing urea is soft Cream.
By changing Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases Example can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% mass fractions Sour Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine (1%ACEI+2%L-733060+3%DALBK (or HOE-140)+2% of embodiment 99 8% Triamcinolone acetonide acetate) the anti-scar ointment containing numerous emulsifiers preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 70 DEG C of waters bath with thermostatic control It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml Beaker, heating and melting simultaneously stir as oil phase；Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；1g Lei meter Pu are weighed with electronic balance Profit, 2g L-733060,3g DALBK (or HOE-140) and 2g triamcinolone acetonide acetates, Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate adds oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed It is stored in 5 DEG C of refrigerators.Above method obtain 8% compound ACE classes medicine (1%ACEI+2%L-733060+3%DALBK (or HOE-140)+2% triamcinolone acetonide acetate) the anti-scar ointment containing numerous emulsifiers.
By changing Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases Example can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% mass fractions Sour Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 100 5% (1%ACEI+2%L-733060+1%DALBK (or HOE-140)+ 1% triamcinolone acetonide acetate) anti-scar normal saline solution preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：Under room temperature condition, weigh 100g normal saline solutions, 1g Ramiprils, 2g L-733060,1g DALBK (or HOE-140) and 1g are weighed with electronic balance Triamcinolone acetonide acetate is added in physiological saline and is sufficiently stirred.Encapsulation preserves.Above method obtains 5% compound ACE classes medicine (1% The triamcinolone acetonide acetates of ACEI+2%L-733060+1%DALBK (or HOE-140)+1%) anti-scar normal saline solution.
By changing physiological saline and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate quality Proportioning can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+acetic acid song of 0.05-25% concentration An Naide) anti-scar normal saline solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 101 7% (2%ACEI+2%L-733060+2%DALBK (or HOE-140)+ 1% triamcinolone acetonide acetate) anti-scar gel preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：Under room temperature condition, weigh 72g normal saline solutions, how add 2g Ramiprils, 2g L-733060,2g DALBK (or HOE-140) and 1g acetic acid Qu An Moral fully dissolves, and adds 3g sodium carboxymethylcelluloses, is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fat Fat acid sorb is smooth.Above method obtains 7% compound ACE classes medicine (2%ACEI+2%L-733060+2%DALBK (or HOE- 140)+1% triamcinolone acetonide acetate) anti-scar gel.
By the matter for changing physiological saline and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate Amount proportioning can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% concentration Triamcinolone acetonide) anti-scar gel, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 102 5% (2%ACEI+1%L-733060+1%DALBK (or HOE-140)+ 1% triamcinolone acetonide acetate) anti-scar plastics preparation method
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：Weigh 8g polyvinyl alcohol (PVA) it is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs It is extremely well mixed.How it is eventually adding 2g Ramiprils, 1g L-733060,1g DALBK (or HOE-140) and 1g acetic acid Qu An Moral, it is stirred well to and is completely dissolved, is cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate Quality proportioning can obtain 0.4% compound ACE classes medicine (ACEI+L-733060+DALBK (or the HOE- of 0.05-25% concentration 140)+triamcinolone acetonide acetate) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 103 15% (4%ACEI+4%L-733060+4%DALBK (or HOE-140)+ 3% triamcinolone acetonide acetate) anti-scar bar cloth patch preparation method
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 50 DEG C of waters bath with thermostatic control In, 4g Ramiprils, 4g L-733060,4g DALBK (or HOE-140) and 3g triamcinolone acetonide acetates are taken, is dissolved in 80g distilled water In, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid；Separately 4g Sodium Polyacrylates are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and is stirred well to It is well mixed, it is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 15% compound ACE classes The anti-scar bar cloth patch of medicine (triamcinolone acetonide acetates of 4%ACEI+4%L-733060+4%DALBK (or HOE-140)+3%).
Matrix and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate are pasted by changing bar cloth Quality proportioning can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% concentration Sour Triamcinolone acetonide) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 104 13% (3%ACEI+3%L-733060+4%DALBK (or HOE-140)+ 3% triamcinolone acetonide acetate) anti-scar spray preparation method
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 100g physiological saline In, 3g Ramiprils, 3g L-733060,4g DALBK (or HOE-140) and 3g triamcinolone acetonide acetates and 1g urea are added, is filled Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate Quality proportioning can obtain the compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+vinegar of 0.05-25% concentration Sour Triamcinolone acetonide) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 105 11% (2%ACEI+1%L-733060+3%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：70 Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs Uniformly it is used as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings are used as aqueous phase；2g captoprils, 1g L-733060,3g DALBK (or HOE-140), 2g oceans are weighed with electronic balance Herba Alii fistulosi extract and 3g triamcinolone acetonide acetates, captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, onion Extract adds oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators In.Above method obtains 11% compound ACE classes medicine (2%ACEI+1%L-733060+3%DALBK (or HOE-140)+3% The Bulbus Allii Cepae extract of triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
By change captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 106 8% (1%ACEI+3%L-733060+1%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：70 Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs Uniformly it is used as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings are used as aqueous phase；1g captoprils, 3g L-733060,1g DALBK (or HOE-140), 2g oceans are weighed with electronic balance Herba Alii fistulosi extract and 1g triamcinolone acetonide acetates, captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, onion Extract adds oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 In DEG C refrigerator.Above method obtains 8% compound ACE classes medicine (1%ACEI+3%L-733060+1%DALBK (or HOE-140) The Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
By change captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 107 6% (2%ACEI+1%L-733060+1%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) the anti-scar ointment containing numerous emulsifiers preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：70 By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g in DEG C water bath with thermostatic control 100ml beakers are put into, heating and melting simultaneously stirs as oil phase；Taken in 70 DEG C of waters bath with thermostatic control distilled water 60mL, glycerine 10ml, Lauryl sodium sulfate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；Weighed with electronic balance 2g captoprils, 1g L-733060,1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates, Kato Puli, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving；Finally by aqueous phase Oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 6% compound ACE class medicines (Bulbus Allii Cepae extract of 2%ACEI+1%L-733060+1%DALBK (or HOE-140)+1% triamcinolone acetonide acetate+1%) is containing a variety of The anti-scar ointment of emulsifying agent.
By change captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 108 0.5% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or HOE-140) the Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar normal saline solution preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Room temperature Under the conditions of, weigh 100g normal saline solutions, with electronic balance weigh 100mg captoprils, 100mg L-733060, 100mgDALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates are added in physiological saline and fully stirred Mix.Encapsulation preserves.Above method obtains 0.5% compound ACE class medicines (0.1%ACEI+0.1%L-733060+0.1%DALBK The Bulbus Allii Cepae extract of (or HOE-140)+0.1% triamcinolone acetonide acetate+0.1%) anti-scar normal saline solution.
By changing physiological saline and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and ocean Herba Alii fistulosi extract quality proportioning can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE- 140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar normal saline solution, for different type scar or to obtain optimal Anti- scar effect.
The compound ACE classes medicine of embodiment 109 7% (2%ACEI+1%L-733060+2%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar gel preparation
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Room temperature Under the conditions of, 72g normal saline solutions are weighed, add 2g captoprils, 1g L-733060,2g DALBK (or HOE-140), 1g Bulbus Allii Cepae extract and 1g triamcinolone acetonide acetates fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C. It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 7% compound ACE class medicines (2%ACEI+1%L- The Bulbus Allii Cepae extract of 733060+2%DALBK (or HOE-140)+1% triamcinolone acetonide acetate+1%) anti-scar gel.
By changing physiological saline and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and ocean The quality proportioning of Herba Alii fistulosi extract can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar gel, for different type scar or to obtain optimal anti-scar Trace effect.
The compound ACE classes medicine of embodiment 110 15% (3%ACEI+3%L-733060+3%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+3%) anti-scar plastics preparation method
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Weigh 8g polyvinyl alcohol (PVA) is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, adds 3ml glycerine, stir to well mixed.It is eventually adding 3g captoprils, 3g L-733060,3g DALBK (or HOE-140), 3g Bulbus Allii Cepae extract and 3g triamcinolone acetonide acetates, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By change plastics matrix and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and The quality proportioning of Bulbus Allii Cepae extract can obtain 0.4% compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar plastics, for different type scar or to take Obtain most preferably anti-scar effect.
The compound ACE classes medicine of embodiment 111 12% (3%ACEI+2%L-733060+3%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) anti-scar bar cloth patch preparation method
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：50 In DEG C water bath with thermostatic control, 3g captoprils, 2g L-733060,3g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts and 2g vinegar are taken Sour Triamcinolone acetonide, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With Upper method obtains 12% compound ACE classes medicine, and (acetic acid of 3%ACEI+2%L-733060+3%DALBK (or HOE-140)+2% is bent The Bulbus Allii Cepae extracts of An Naide+2%) anti-scar bar cloth patch.
By change bar cloth paste matrix and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar bar cloth patch, for different type scar or to obtain optimal anti- Scar effect.
The compound ACE classes medicine of embodiment 112 9% (2%ACEI+3%L-733060+2%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar spray preparation method
By taking captopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example： In 100g physiological saline, add 2g captoprils, 3g L-733060,2g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts and 1g triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and captopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ACEI+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar spray, for different type scar or to obtain optimal anti- Scar effect.
The compound ACE classes medicine of embodiment 113 0.6% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or HOE-140) the liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar ointment containing urea preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing in 70 DEG C of waters bath with thermostatic control And stir as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add Urea 10g dissolvings are used as aqueous phase；With electronic balance weigh 100mg lisinoprils, 100mg L-733060,100mgDALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；Finally aqueous phase oil phase is mixed Merging, which is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.6% compound ACE class medicines (onion of 0.1%ACEI+0.1%L-733060+0.1%DALBK (or HOE-140)+0.1% triamcinolone acetonide acetate+0.1% carries Take the liquaemin of thing+0.1%) the anti-scar ointment containing urea.
By changing lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion The ratio of extract and ointment bases can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% mass fractions DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 114 10% (1%ACEI+2%L-733060+3%DALBK (or HOE-140)+ The liquaemin of+1% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+1%) the anti-scar ointment containing urea preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing in 70 DEG C of waters bath with thermostatic control And stir as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add Urea 10g dissolvings are used as aqueous phase；With electronic balance weigh 1g lisinoprils, 2g L-733060,3g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 1g liquaemins, lisinopril, L-733060, DALBK (or HOE-140), acetic acid Triamcinolone acetonide, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue to stir Mix to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 10% compound ACE class medicines (1%ACEI+2%L- The liquaemin of+1% Bulbus Allii Cepae extract of 733060+3%DALBK (or HOE-140)+2% triamcinolone acetonide acetate+1%) the anti-scar containing urea Trace ointment.
By changing lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion The ratio of extract and ointment bases can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% mass fractions DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 115 17% (6%ACEI+2%L-733060+3%DALBK (or HOE-140)+ The liquaemin of+2% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing numerous emulsifiers preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, nipalgin in 70 DEG C of waters bath with thermostatic control Ethyl ester 0.3g is put into 100ml beakers, and heating and melting simultaneously stirs as oil phase；Taken in 70 DEG C of waters bath with thermostatic control distilled water 60mL, Glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；Use electronics How balance weighs 6g lisinoprils, 2g L-733060,3g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts, 2g acetic acid Qu An Moral and 2g liquaemins, lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, heparin Sodium adds oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.With Upper method obtains 17% compound ACE classes medicine, and (acetic acid of 6%ACEI+2%L-733060+3%DALBK (or HOE-140)+2% is bent The liquaemin of the Bulbus Allii Cepae extracts of An Naide+2%+2%) the anti-scar ointment containing numerous emulsifiers.
By changing lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin, onion carry The ratio of thing and ointment bases is taken to obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% mass fractions DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 116 10% (3%ACEI+2%L-733060+2%DALBK (or HOE-140)+ The liquaemin of+1% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar normal saline solution preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：Under room temperature condition, weigh 100g normal saline solutions, with electronic balance weigh 3g lisinoprils, 2g L-733060, 2gDALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins are added in physiological saline and fully stirred Mix.Encapsulation preserves.Above method obtains 10% compound ACE classes medicine (3%ACEI+2%L-733060+2%DALBK (or HOE- 140) liquaemin of+1% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%) anti-scar normal saline solution.
By changing physiological saline and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver Plain sodium, Bulbus Allii Cepae extract quality proportioning can obtain the compound ACE class medicines (ACEI+L-733060+DALBK of 0.05-25% concentration (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar normal saline solution, with for different type Scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 117 19% (6%ACEI+3%L-733060+2%DALBK (or HOE-140)+ The liquaemin of+2% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+4%) anti-scar gel preparation
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：Under room temperature condition, 72g normal saline solutions are weighed, add 6g lisinoprils, 3g L-733060,2g DALBK (or HOE- 140), 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 4g liquaemins fully dissolve, and add 3g sodium carboxymethylcelluloses, and 25 It is swelled overnight under the conditions of DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 19% compound ACE classes Medicine (Bulbus Allii Cepae extract of 6%ACEI+3%L-733060+2%DALBK (or HOE-140)+2% triamcinolone acetonide acetate+2%+ 4% liquaemin) anti-scar gel.
By changing physiological saline and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver Plain sodium, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar gel, with for different type scar Or obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 118 0.6% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or HOE-140) the liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar plastics preparation method
By taking lisinopril+L-733060+DALBK (or HOE-140) as an example：8g polyvinyl alcohol (PVA) is weighed to be added to In 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed. Be eventually adding 100mg lisinoprils, 100mg L-733060,100mg DALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By change plastics matrix and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Liquaemin, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar plastics, with for different type scar Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 119 15% (2%ACEI+2%L-733060+2%DALBK (or HOE-140)+ The liquaemin of+4% Bulbus Allii Cepae extract of 4% triamcinolone acetonide acetate+1%) anti-scar bar cloth patch preparation method
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：In 50 DEG C of waters bath with thermostatic control, 2g lisinoprils, 2g L-733060,2g DALBK (or HOE-140), the extraction of 4g onions are taken Thing, 4g triamcinolone acetonide acetates and 1g liquaemins, are dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving is stirred Mix uniformly, obtain B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, Cover adherent layer, stripping and slicing.Above method obtain 15% compound ACE classes medicine (2%ACEI+2%L-733060+2%DALBK (or HOE-140) the liquaemin of+4% Bulbus Allii Cepae extract of+4% triamcinolone acetonide acetate+1%) anti-scar bar cloth patch.
By change bar cloth paste matrix and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Liquaemin, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar bar cloth patch, with for different type scar Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 120 11% (3%ACEI+2%L-733060+2%DALBK (or HOE-140)+ The liquaemin of+2% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar spray preparation method
Using lisinopril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：In 100g physiological saline, 3g lisinoprils, 2g L-733060,2g DALBK (or HOE-140), the extraction of 2g onions are added Thing, 1g triamcinolone acetonide acetates and 1g liquaemins and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and lisinopril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Liquaemin, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ACEI+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar spray, with for different type scar Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 121 25% (4%ACEI+4%L-733060+4%DALBK (or HOE-140)+ The asiaticosid of+4% liquaemin of+6% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+1%) the anti-scar ointment containing urea preparation
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml in 70 DEG C of waters bath with thermostatic control to burn Cup, heating are melted and stirred as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；4g enalaprils, 4g L-733060,4gDALBK are weighed with electronic balance (or HOE-140), 6g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 1g asiaticosids and 4g liquaemins, enalapril, L- 733060th, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving； Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.It is multiple that above method obtains 25% (onion of 4%ACEI+4%L-733060+4%DALBK (or HOE-140)+2% triamcinolone acetonide acetate+6% carries square ACE classes medicine Take the asiaticosid of the liquaemin of thing+4%+1%) the anti-scar ointment containing urea.
By changing enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ACEI+ of 0.05-25% mass fractions L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar containing urea Trace ointment.
The compound ACE classes medicine of embodiment 122 0.7% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) resist containing urea The preparation of scar ointment
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml in 70 DEG C of waters bath with thermostatic control to burn Cup, heating are melted and stirred as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；With electronic balance weigh 100mg enalaprils, 100mg L-733060, 100mg DALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetate 100mg asiaticosids and 100mg Liquaemin, enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and product Asiaticoside adds oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 In DEG C refrigerator.Above method obtain 0.7% compound ACE classes medicine (0.1%ACEI+0.1%L-733060+0.1%DALBK (or HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) resist containing urea Scar ointment.
By changing enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ACEI+ of 0.05-25% mass fractions L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar containing urea Trace ointment.
The compound ACE classes medicine of embodiment 123 21% (3%ACEI+3%L-733060+3%DALBK (or HOE-140)+ The asiaticosid of+3% liquaemin of+3% Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+3%) the anti-scar ointment containing numerous emulsifiers Prepare
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine in 70 DEG C of waters bath with thermostatic control 16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting simultaneously stirs as oil phase；Steaming is taken in 70 DEG C of waters bath with thermostatic control Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as water Phase；3g enalaprils, 3g L-733060,3g DALBK (or HOE-140), 3g Bulbus Allii Cepae extracts, 3g vinegar are weighed with electronic balance Sour Triamcinolone acetonide, 3g asiaticosids and 3g liquaemins, enalapril, L-733060, DALBK (or HOE-140), acetic acid Qu An how Moral, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to Room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 21% compound ACE class medicines (3%ACEI+3%L-733060+ The asiaticosid of+3% liquaemin of 3%DALBK (or HOE-140)+3% Bulbus Allii Cepae extract of+3% triamcinolone acetonide acetate+3%) containing more The kind anti-scar ointment of emulsifying agent.
By changing enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ACEI+ of 0.05-25% mass fractions L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) contain a variety of emulsifications The anti-scar ointment of agent.
The compound ACE classes medicine of embodiment 124 7% (1%ACEI+1%L-733060+1%DALBK (or HOE-140)+ The asiaticosid of+1% liquaemin of+1% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar normal saline solution preparation
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：Under room temperature condition, 100g normal saline solutions are weighed, 1g enalaprils, 1g L- are weighed with electronic balance 733060th, 1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins add Enter in physiological saline and be sufficiently stirred.Encapsulation preserves.Above method obtains 7% compound ACE class medicines (1%ACEI+1%L- The centella of+1% liquaemin of 733060+1%DALBK (or HOE-140)+1% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1% Glycosides) anti-scar normal saline solution.
By changing physiological saline and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, ocean Herba Alii fistulosi extract, liquaemin and asiaticosid quality proportioning can obtain the compound ACE class medicines (ACEI+L- of 0.05-25% concentration 733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar physiology salt The aqueous solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 125 15% (3%ACEI+2%L-733060+2%DALBK (or HOE-140)+ The asiaticosid of+2% liquaemin of+2% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) anti-scar gel preparation
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：Under room temperature condition, 72g normal saline solutions are weighed, add 3g enalaprils, 2g L-733060,2g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins fully dissolve, then 3g sodium carboxymethylcelluloses are added, are swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With Upper method obtains 15% compound ACE classes medicine, and (acetic acid of 3%ACEI+2%L-733060+2%DALBK (or HOE-140)+2% is bent The asiaticosid of+2% liquaemin of the Bulbus Allii Cepae extracts of An Naide+2%+2%) anti-scar gel.
By changing physiological saline and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, ocean The quality proportioning of Herba Alii fistulosi extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ACEI+L- of 0.05-25% concentration 733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar gel, with For different type scar or obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 126 10% (2%ACEI+3%L-733060+1%DALBK (or HOE-140)+ The asiaticosid of+1% liquaemin of+1% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar plastics preparation method
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：Weigh 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, be stirred well in 90 DEG C of waters bath with thermostatic control It is completely dissolved, adds 3ml glycerine, stirs to well mixed.It is eventually adding 2g enalaprils, 3g L-733060,1gDALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins, it is stirred well to completely molten Solution, is cooled to room temperature.Encapsulation preserves.
By change plastics matrix and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ACEI+ of 0.05-25% concentration L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar film Agent, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 127 10% (1%ACEI+2%L-733060+2%DALBK (or HOE-140)+ The asiaticosid of+1% liquaemin of+2% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+1%) anti-scar bar cloth patch preparation method
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：In 50 DEG C of waters bath with thermostatic control, 1g enalaprils, 2g L-733060,2g DALBK (or HOE-140), 2g are taken Bulbus Allii Cepae extract, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins, are dissolved in 80g distilled water, are added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added Into 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room Temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 10% compound ACE class medicines (1%ACEI+2%L- The centella of+1% liquaemin of 733060+2%DALBK (or HOE-140)+2% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1% Glycosides) anti-scar bar cloth patch.
By change bar cloth paste matrix and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ACEI+ of 0.05-25% concentration L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar bar cloth Patch, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 128 0.7% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) spray of anti-scar Mist agent preparation method
With enalapril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：In 100g physiological saline, add 0.1g enalaprils, 0.1g L-733060,0.1g DALBK (or HOE-140), 0.1g Bulbus Allii Cepae extracts, 0.1g triamcinolone acetonide acetates, 0.1g asiaticosids and 0.1g liquaemins and 1g urea, fill Divide and stir.And it is fitted into spray bottle.
By change spray reclaimed water and enalapril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ACEI+ of 0.05-25% concentration L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) spraying of anti-scar Agent, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (2%ARB+1%L-733060+3%DALBK (or HOE-140)+2% of embodiment 129 8% Triamcinolone acetonide acetate) the anti-scar ointment containing urea preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 70 DEG C of waters bath with thermostatic control Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil Phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts Aqueous phase；How 2g Losartan Potassiums, 1g L-733060,3g DALBK (or HOE-140) and 2g acetic acid Qu An are weighed with electronic balance Moral, Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate add oil phase dissolving；Finally by aqueous phase oil phase Mix and be sufficiently stirred and be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 8% compound ACE classes medicine (2% The triamcinolone acetonide acetates of ARB+1%L-733060+3%DALBK (or HOE-140)+2%) the anti-scar ointment containing urea.
By changing Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases Example can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% mass fractions Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 130 0.4% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE- 140)+0.1% triamcinolone acetonide acetate) the anti-scar ointment containing urea preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 70 DEG C of waters bath with thermostatic control Middle that magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating is melted and stirred as oil Phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolving conducts Aqueous phase；100mg Losartan Potassiums, 100mg L-733060,100mg DALBK (or HOE-140) and 100mg are weighed with electronic balance Triamcinolone acetonide acetate, Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate add oil phase dissolving；Water oil Mix and be sufficiently stirred and add 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 0.4% compound ACE classes medicine (the acetic acid Qu An of 0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-140)+0.1% Nai De) the anti-scar ointment containing urea.
By changing Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases Example can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% mass fractions Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or HOE-140)+1% of embodiment 131 6% Triamcinolone acetonide acetate) the anti-scar ointment containing numerous emulsifiers preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 70 DEG C of waters bath with thermostatic control It is middle that stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml Beaker, heating and melting simultaneously stir as oil phase；Distilled water 60mL, glycerine 10ml, dodecyl are taken in 70 DEG C of waters bath with thermostatic control Sodium sulphate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；1g Losartans are weighed with electronic balance Potassium, 2g L-733060,2g DALBK (or HOE-140) and 1g triamcinolone acetonide acetates, Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate adds oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed It is stored in 5 DEG C of refrigerators.Above method obtain 6% compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or HOE-140)+1% triamcinolone acetonide acetate) the anti-scar ointment containing numerous emulsifiers.
By changing Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and the ratio of ointment bases Example can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% mass fractions Triamcinolone acetonide) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 132 12% (3%ARB+4%L-733060+2%DALBK (or HOE-140)+ 3% triamcinolone acetonide acetate) anti-scar normal saline solution preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：Under room temperature condition, weigh 100g normal saline solutions, 3g Losartan Potassiums, 4g L-733060,2g DALBK (or HOE-140) and 3g are weighed with electronic balance Triamcinolone acetonide acetate is added in physiological saline and is sufficiently stirred.Encapsulation preserves.Above method obtains 12% compound ACE classes medicine (3% The triamcinolone acetonide acetates of ARB+4%L-733060+2%DALBK (or HOE-140)+3%) anti-scar normal saline solution.
By changing physiological saline and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate quality Proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid Qu An of 0.05-25% concentration Nai De) anti-scar normal saline solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (3%ARB+2%L-733060+1%DALBK (or HOE-140)+1% of embodiment 133 7% Triamcinolone acetonide acetate) anti-scar gel preparation
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：Under room temperature condition, weigh 72g normal saline solutions, how add 3g Losartan Potassiums, 2g L-733060,1g DALBK (or HOE-140) and 1g acetic acid Qu An Moral fully dissolves, and adds 3g sodium carboxymethylcelluloses, is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fat Fat acid sorb is smooth.Above method obtains 7% compound ACE classes medicine (3%ARB+2%L-733060+1%DALBK (or HOE- 140)+1% triamcinolone acetonide acetate) anti-scar gel.
By the matter for changing physiological saline and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate Amount proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid song of 0.05-25% concentration An Naide) anti-scar gel, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 134 20% (5%ARB+5%L-733060+5%DALBK (or HOE-140)+ 5% triamcinolone acetonide acetate) anti-scar plastics preparation method
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：Weigh 8g polyvinyl alcohol (PVA) it is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs It is extremely well mixed.How it is eventually adding 5g Losartan Potassiums, 5g L-733060,5g DALBK (or HOE-140) and 5g acetic acid Qu An Moral, it is stirred well to and is completely dissolved, is cooled to room temperature.Encapsulation preserves.
By changing plastics matrix and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate Quality proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% concentration Triamcinolone acetonide) anti-scar plastics, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 135 11% (6%ARB+2%L-733060+1%DALBK (or
HOE-140)+2% triamcinolone acetonide acetate) anti-scar bar cloth patch preparation method
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 50 DEG C of waters bath with thermostatic control In, 6g Losartan Potassiums, 2g L-733060,1g DALBK (or HOE-140) and 2g triamcinolone acetonide acetates are taken, is dissolved in 80g distilled water In, 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na are added into the aqueous solution, obtains A liquid；Separately 4g Sodium Polyacrylates are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and is stirred well to It is well mixed, it is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 11% compound ACE classes The anti-scar bar cloth patch of medicine (triamcinolone acetonide acetates of 6%ARB+2%L-733060+1%DALBK (or HOE-140)+2%).
Matrix and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate are pasted by changing bar cloth Quality proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% concentration Triamcinolone acetonide) anti-scar bar cloth patch, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine (2%ARB+2%L-733060+1%DALBK (or HOE-140)+1% of embodiment 136 6% Triamcinolone acetonide acetate) anti-scar spray preparation method
By taking Losartan Potassium+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate as an example：In 100g physiological saline In, 2g Losartan Potassiums, 2g L-733060,1g DALBK (or HOE-140) and 1g triamcinolone acetonide acetates and 1g urea are added, is filled Divide and stir.And it is fitted into spray bottle.
By changing spray reclaimed water and Losartan Potassium, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate Quality proportioning can obtain the compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+acetic acid of 0.05-25% concentration Triamcinolone acetonide) anti-scar spray, for different type scar or to obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 137 0.5% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE- 140) Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar ointment containing urea preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：70 Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs Uniformly it is used as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings are used as aqueous phase；100mg Irbesartans, 100mg L-733060,100mg DALBK (or HOE- are weighed with electronic balance 140), 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates, Irbesartan, L-733060, DALBK (or HOE-140), vinegar Sour Triamcinolone acetonide, Bulbus Allii Cepae extract add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed It is stored in 5 DEG C of refrigerators.Above method obtains 0.5% compound ACE class medicines (0.1%ARB+0.1%L-733060+0.1% The Bulbus Allii Cepae extract of DALBK (or HOE-140)+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar ointment containing urea.
By change Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 138 14% (2%ARB+1%L-733060+6%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：70 Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in DEG C water bath with thermostatic control, heating, which is melted, simultaneously stirs Uniformly it is used as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings are used as aqueous phase；2g Irbesartans, 1g L-733060,6g DALBK (or HOE-140), 2g oceans are weighed with electronic balance Herba Alii fistulosi extract and 1g triamcinolone acetonide acetates, Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, onion Extract adds oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 In DEG C refrigerator.Above method obtains 14% compound ACE classes medicine (2%ARB+1%L-733060+6%DALBK (or HOE-140) The Bulbus Allii Cepae extract of+3% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
By change Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 139 10% (2%ARB+2%L-733060+2%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing numerous emulsifiers preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：70 By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g in DEG C water bath with thermostatic control 100ml beakers are put into, heating and melting simultaneously stirs as oil phase；Taken in 70 DEG C of waters bath with thermostatic control distilled water 60mL, glycerine 10ml, Lauryl sodium sulfate 0.6g, which is added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；Weighed with electronic balance 2g Irbesartans, 2g L-733060,2g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts and 2g triamcinolone acetonide acetates, E Bei Sha Tan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract add oil phase dissolving；Finally by aqueous phase Oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 10% compound ACE class medicines Thing (Bulbus Allii Cepae extract of 2%ARB+2%L-733060+2%DALBK (or HOE-140)+2% triamcinolone acetonide acetate+2%) is containing more The kind anti-scar ointment of emulsifying agent.
By change Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and Bulbus Allii Cepae extract and The ratio of ointment bases can obtain 0.05-25% mass fractions compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 140 20% (4%ARB+4%L-733060+4%DALBK (or HOE-140)+ The Bulbus Allii Cepae extract of 4% triamcinolone acetonide acetate+4%) anti-scar normal saline solution preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Room temperature Under the conditions of, weigh 100g normal saline solutions, with electronic balance weigh 4g Irbesartans, 4g L-733060,4g DALBK (or HOE-140), 4g Bulbus Allii Cepae extracts and 4g triamcinolone acetonide acetates, which are added in physiological saline, is sufficiently stirred.Encapsulation preserves.Above method Obtain 20% compound ACE classes medicine (triamcinolone acetonide acetates of 4%ARB+4%L-733060+4%DALBK (or HOE-140)+4%+ 4% Bulbus Allii Cepae extract) anti-scar normal saline solution.
By changing physiological saline and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and ocean Herba Alii fistulosi extract quality proportioning can obtain 0.05-25% concentration 0.4% compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar normal saline solution, with for different type scar or acquirement Optimal anti-scar effect.
The compound ACE classes medicine (1%ARB+1%L-733060+1%DALBK (or HOE-140)+1% of embodiment 141 5% The Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%) anti-scar gel preparation
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Room temperature Under the conditions of, 72g normal saline solutions are weighed, add 1g Irbesartans, 1g L-733060,1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extract and 1g triamcinolone acetonide acetates fully dissolve, and add 3g sodium carboxymethylcelluloses, are swelled overnight under the conditions of 25 DEG C. It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 5% compound ACE class medicines (1%ARB+1%L- The Bulbus Allii Cepae extract of 733060+1%DALBK (or HOE-140)+1% triamcinolone acetonide acetate+1%) anti-scar gel.
By changing physiological saline and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and ocean The quality proportioning of Herba Alii fistulosi extract can obtain 0.05-25% concentration compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar gel, for different type scar or to obtain optimal anti-scar Trace effect.
The compound ACE classes medicine of embodiment 142 0.5% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE- 140) Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar plastics preparation method
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：Weigh 8g polyvinyl alcohol (PVA) is added in 88ml distilled water, is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, adds 3ml glycerine, stir to well mixed.Be eventually adding 100mg Irbesartans, 100mg L-733060,100mg DALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts and 100mg triamcinolone acetonide acetates, are stirred well to and are completely dissolved, be cooled to room temperature.Envelope Dress preserves.
By change plastics matrix and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar plastics, for different type scar or to obtain optimal anti- Scar effect.
The compound ACE classes medicine of embodiment 143 11% (1%ARB+3%L-733060+3%DALBK (or
HOE-140) the Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+3%) anti-scar bar cloth patch preparation method
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example：50 In DEG C water bath with thermostatic control, 1g Irbesartans, 3g L-733060,3g DALBK (or HOE-140), 3g Bulbus Allii Cepae extracts and 1g vinegar are taken Sour Triamcinolone acetonide, be dissolved in 80g distilled water, added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.With Upper method obtains 11% compound ACE classes medicine, and (acetic acid of 1%ARB+3%L-733060+3%DALBK (or HOE-140)+1% is bent The Bulbus Allii Cepae extracts of An Naide+3%) anti-scar bar cloth patch.
By change bar cloth paste matrix and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar bar cloth patch, for different type scar or to obtain optimal anti- Scar effect.
The compound ACE classes medicine of embodiment 144 0.5% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE- 140) Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar spray preparation method
By taking Irbesartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract as an example： In 100g physiological saline, 100mg Irbesartans, 100mg L-733060,100mg DALBK (or HOE-140), 100mg are added Bulbus Allii Cepae extract and 100mg triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and Irbesartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate and The quality proportioning of Bulbus Allii Cepae extract can obtain 0.05-25% concentration compound ACE classes medicine (ARB+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract) anti-scar spray, for different type scar or to obtain optimal anti- Scar effect.
The compound ACE classes medicine of embodiment 145 0.6% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE- 140) liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar ointment containing urea preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing in 70 DEG C of waters bath with thermostatic control And stir as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add Urea 10g dissolvings are used as aqueous phase；With electronic balance weigh 100mg Valsartans, 100mg L-733060,100mg DALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins, Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；Finally aqueous phase oil phase is mixed and filled Divide stirring to be cooled to room temperature, be sealed in 5 DEG C of refrigerators.Above method obtains 0.6% compound ACE class medicines (0.1%ARB+ The liver of+0.1% Bulbus Allii Cepae extract of 0.1%L-733060+0.1%DALBK (or HOE-140)+0.1% triamcinolone acetonide acetate+0.1% Plain sodium) the anti-scar ointment containing urea.
Carried by changing Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion The ratio of thing and ointment bases is taken to obtain the compound ACE classes medicine (Valsartan+L-733060+ of 0.05-25% mass fractions DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 146 16% (2%ARB+6%L-733060+2%DALBK (or HOE-140)+ The liquaemin of+2% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing in 70 DEG C of waters bath with thermostatic control And stir as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add Urea 10g dissolvings are used as aqueous phase；2g Valsartans, 6g L-733060,2g DALBK (or HOE-140), 2g are weighed with electronic balance Bulbus Allii Cepae extract, 2g triamcinolone acetonide acetates and 2g liquaemins, Valsartan, L-733060, DALBK (or HOE-140), acetic acid Qu An Nai De, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring extremely Room temperature.Sealed storage is in 5 DEG C of refrigerators.Above method obtains 16% compound ACE class medicines (2%ARB+6%L-733060+2% The liquaemin of+2% Bulbus Allii Cepae extract of DALBK (or HOE-140)+2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
Carried by changing Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion The ratio of thing and ointment bases is taken to obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% mass fractions DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine (1%ARB+2%L-733060+1%DALBK (or HOE-140)+2% of embodiment 147 8% The liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%+1%) the anti-scar ointment containing numerous emulsifiers preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, nipalgin in 70 DEG C of waters bath with thermostatic control Ethyl ester 0.3g is put into 100ml beakers, and heating and melting simultaneously stirs as oil phase；Taken in 70 DEG C of waters bath with thermostatic control distilled water 60mL, Glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as aqueous phase；Use electronics Balance weighs 1g Valsartans, 2g L-733060,1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates With 1g liquaemins, Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin add Enter oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.With top Method obtains the 8% compound ACE classes medicine (triamcinolone acetonide acetates of 1%ARB+2%L-733060+1%DALBK (or HOE-140)+2% The liquaemin of+1% Bulbus Allii Cepae extract+1%) the anti-scar ointment containing numerous emulsifiers.
Carried by changing Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liquaemin and onion The ratio of thing and ointment bases is taken to obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% mass fractions DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing numerous emulsifiers.
The compound ACE classes medicine of embodiment 148 13% (2%ARB+1%L-733060+1%DALBK (or HOE-140)+ The liquaemin of+3% Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+3%) anti-scar normal saline solution preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：Under room temperature condition, 100g normal saline solutions are weighed, 2g Valsartans, 1g L-733060,1g are weighed with electronic balance DALBK (or HOE-140), 3mg Bulbus Allii Cepae extracts, 3g triamcinolone acetonide acetates and 3g liquaemins are added in physiological saline and fully stirred Mix.Encapsulation preserves.Above method obtains 13% compound ACE classes medicine (2%ARB+1%L-733060+1%DALBK (or HOE- 140) liquaemin of+3% Bulbus Allii Cepae extract of+3% triamcinolone acetonide acetate+3%) anti-scar normal saline solution.
By changing physiological saline and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, heparin Sodium and Bulbus Allii Cepae extract quality proportioning can obtain the compound ACE class medicines (ARB+L-733060+DALBK of 0.05-25% concentration (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar normal saline solution, with for different type Scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 149 0.6% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE- 140) liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) anti-scar gel preparation
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：Under room temperature condition, 72g normal saline solutions are weighed, add 100mg Valsartans, 100mg L-733060,100mg DALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates and 100mg liquaemins fully dissolve, and add 3g carboxylics Sodium carboxymethylcellulose pyce, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains To 0.6% compound ACE classes medicine, (acetic acid of 0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-140)+0.1% is bent The liquaemin of the Bulbus Allii Cepae extracts of An Naide+0.1%+0.1%) anti-scar gel.
By changing physiological saline and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, heparin The quality proportioning of sodium and Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ARB+L-733060+DALBK of 0.05-25% concentration (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar gel, for different type scar or to take Obtain most preferably anti-scar effect.
The compound ACE classes medicine of embodiment 150 22% (6%ARB+2%L-733060+4%DALBK (or HOE-140)+ The liquaemin of+4% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+4%) anti-scar plastics preparation method
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：Weigh 8g polyvinyl alcohol (PVA) to be added in 88ml distilled water, be stirred well to and be completely dissolved in 90 DEG C of waters bath with thermostatic control, 3ml glycerine is added, is stirred to well mixed.It is eventually adding 6g Valsartans, 2g L-733060,4g DALBK (or HOE- 140), 4g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates and 4g liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation Preserve.
By changing plastics matrix and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver The quality proportioning of plain sodium and Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar plastics, with for different type scar Trace obtains optimal anti-scar effect.
The compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or HOE-140)+1% of embodiment 151 9% The liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+2%+1%) anti-scar bar cloth patch preparation method
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：In 50 DEG C of waters bath with thermostatic control, take 1g Valsartans, 2g L-733060,2g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates and 1g liquaemins, are dissolved in 80g distilled water, and 2.5g carbomers, 5g glycerine, 2.5g are added into the aqueous solution Gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirring is equal It is even, obtain B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, covered Adherent layer, stripping and slicing.Above method obtains 9% compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or HOE- 140) liquaemin of+2% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%) anti-scar bar cloth patch.
Matrix and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver are pasted by changing bar cloth Plain sodium, the quality proportioning of Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar bar cloth patch, with for different type scar Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 152 14% (3%ARB+2%L-733060+3%DALBK (or HOE-140)+ The liquaemin of+2% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+3%) anti-scar spray preparation method
Using Valsartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin as Example：In 100g physiological saline, 3g Valsartans, 2g L-733060,3g DALBK (or HOE-140), the extraction of 2g onions are added Thing, 1g triamcinolone acetonide acetates and 3g liquaemins and 1g urea, are stirred.And it is fitted into spray bottle.
By changing spray reclaimed water and Valsartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, liver The quality proportioning of plain sodium and Bulbus Allii Cepae extract can obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin) anti-scar spray, with for different type scar Trace obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 153 24% (2%ARB+2%L-733060+4%DALBK (or HOE-140)+ The asiaticosid of+4% liquaemin of+4% Bulbus Allii Cepae extract of 6% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml in 70 DEG C of waters bath with thermostatic control to burn Cup, heating are melted and stirred as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；2g Telmisartans, 2g L-733060,4gDALBK are weighed with electronic balance (or HOE-140), 4g Bulbus Allii Cepae extracts, 6g triamcinolone acetonide acetates, 2g asiaticosids and 4g liquaemins, Telmisartan, L- 733060th, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving； Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.It is multiple that above method obtains 24% (onion of 2%ARB+2%L-733060+4%DALBK (or HOE-140)+6% triamcinolone acetonide acetate+4% carries square ACE classes medicine Take the asiaticosid of the liquaemin of thing+4%+2%) the anti-scar ointment containing urea.
By changing Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ARB+L- of 0.05-25% mass fractions 733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar containing urea Ointment.
The compound ACE classes medicine of embodiment 154 0.7% (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE- 140) asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) the anti-scar containing urea The preparation of ointment
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml in 70 DEG C of waters bath with thermostatic control to burn Cup, heating are melted and stirred as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control to be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；With electronic balance weigh 100mg Telmisartans, 100mg L-733060, 100mg DALBK (or HOE-140), 100mg Bulbus Allii Cepae extracts, 100mg triamcinolone acetonide acetates, 100mg asiaticosids and 100mg Liquaemin, Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liquaemin and product Asiaticoside adds oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 In DEG C refrigerator.Above method obtain 0.7% compound ACE classes medicine (0.1%ARB+0.1%L-733060+0.1%DALBK (or HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract of+0.1% triamcinolone acetonide acetate+0.1%) resist containing urea Scar ointment.
By changing Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ARB+L- of 0.05-25% mass fractions 733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) the anti-scar containing urea Ointment.
The compound ACE classes medicine (1%ARB+1%L-733060+1%DALBK (or HOE-140)+1% of embodiment 155 7% The asiaticosid of+1% liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%+1%) the anti-scar ointment containing numerous emulsifiers preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine in 70 DEG C of waters bath with thermostatic control 16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting simultaneously stirs as oil phase；Steaming is taken in 70 DEG C of waters bath with thermostatic control Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as water Phase；1g Telmisartans, 1g L-733060,1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g vinegar are weighed with electronic balance Sour Triamcinolone acetonide, 1g asiaticosids and 1g liquaemins, Telmisartan, L-733060, DALBK (or HOE-140), acetic acid Qu An how Moral, Bulbus Allii Cepae extract, liquaemin and asiaticosid add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to Room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 7% compound ACE class medicines (1%ARB+1%L-733060+1% The asiaticosid of+1% liquaemin of DALBK (or HOE-140)+1% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%) contain a variety of breasts The anti-scar ointment of agent.
By changing Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, Bulbus Allii Cepae extract, liver The ratio of plain sodium and asiaticosid and ointment bases can obtain the compound ACE class medicines (ARB+L- of 0.05-25% mass fractions 733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) contain numerous emulsifiers Anti- scar ointment.
The compound ACE classes medicine (2%ARB+1%L-733060+1%DALBK (or HOE-140)+1% of embodiment 156 8% The asiaticosid of+1% liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%+1%) anti-scar normal saline solution preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：Under room temperature condition, 100g normal saline solutions are weighed, 2g Telmisartans, 1g L- are weighed with electronic balance 733060th, 1g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins add Enter in physiological saline and be sufficiently stirred.Encapsulation preserves.Above method obtains 8% compound ACE class medicines (2%ARB+1%L-733060 The asiaticosid of+1% liquaemin of+1%DALBK (or HOE-140)+1% Bulbus Allii Cepae extract of+1% triamcinolone acetonide acetate+1%) anti-scar Trace normal saline solution.
By changing physiological saline and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, ocean Herba Alii fistulosi extract, liquaemin and asiaticosid quality proportioning can obtain the compound ACE class medicines (ARB+L- of 0.05-25% concentration 733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar physiology salt The aqueous solution, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 157 18% (2%ARB+2%L-733060+2%DALBK (or HOE-140)+ The asiaticosid of+2% liquaemin of+6% Bulbus Allii Cepae extract of 2% triamcinolone acetonide acetate+2%) anti-scar gel preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：Under room temperature condition, 72g normal saline solutions are weighed, add 2g Telmisartans, 2g L-733060,2g DALBK (or HOE-140), 6g Bulbus Allii Cepae extracts, 2g triamcinolone acetonide acetates, 2g asiaticosids and 2g liquaemins fully dissolve, then 3g sodium carboxymethylcelluloses are added, are swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.With Upper method obtains 18% compound ACE classes medicine, and (acetic acid of 2%ARB+2%L-733060+2%DALBK (or HOE-140)+2% is bent The asiaticosid of+2% liquaemin of the Bulbus Allii Cepae extracts of An Naide+6%+2%) anti-scar gel.
By changing physiological saline and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, ocean The compound ACE classes medicine that the quality proportioning of Herba Alii fistulosi extract, liquaemin and asiaticosid can obtain 0.05-25% concentration (replaces meter Sha Smooth+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar coagulates Glue, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 158 14% (3%ARB+1%L-733060+2%DALBK (or HOE-140)+ The asiaticosid of+2% liquaemin of+2% Bulbus Allii Cepae extract of 1% triamcinolone acetonide acetate+3%) anti-scar plastics preparation method
By taking Telmisartan+L-733060+DALBK (or HOE-140) as an example：8g polyvinyl alcohol (PVA) is weighed to be added to In 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed. How it is eventually adding 3g Telmisartans, 1g L-733060,2g DALBK (or HOE-140), 2g Bulbus Allii Cepae extracts, 1g acetic acid Qu An Moral, 3g asiaticosids and 2g liquaemins, are stirred well to and are completely dissolved, be cooled to room temperature.Encapsulation preserves.
By change plastics matrix and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ARB+ of 0.05-25% concentration L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar film Agent, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 159 15% (2%ARB+4%L-733060+1%DALBK (or HOE-140)+ The asiaticosid of+1% liquaemin of+2% Bulbus Allii Cepae extract of 3% triamcinolone acetonide acetate+2%) anti-scar bar cloth patch preparation method
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：In 50 DEG C of waters bath with thermostatic control, 2g Telmisartans, 4g L-733060,1g DALBK (or HOE-140), 2g are taken Bulbus Allii Cepae extract, 3g triamcinolone acetonide acetates, 2g asiaticosids and 1g liquaemins, are dissolved in 80g distilled water, are added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added Into 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room Temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 15% compound ACE class medicines (2%ARB+4%L- The centella of+1% liquaemin of 733060+1%DALBK (or HOE-140)+2% Bulbus Allii Cepae extract of+3% triamcinolone acetonide acetate+2% Glycosides) anti-scar bar cloth patch.
By change bar cloth paste matrix and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ARB+ of 0.05-25% concentration L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) anti-scar bar cloth Patch, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine (1%ARB+2%L-733060+2%DALBK (or HOE-140)+1% of embodiment 160 9% The asiaticosid of+1% liquaemin of the Bulbus Allii Cepae extract of triamcinolone acetonide acetate+1%+1%) anti-scar spray preparation method
With Telmisartan+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+ Exemplified by asiaticosid：In 100g physiological saline, add 1g Telmisartans, 2g L-733060,2g DALBK (or HOE-140), 1g Bulbus Allii Cepae extracts, 1g triamcinolone acetonide acetates, 1g asiaticosids and 1g liquaemins and 1g urea, are stirred.And load In spray bottle.
By change spray reclaimed water and Telmisartan, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, The quality proportioning of Bulbus Allii Cepae extract, liquaemin and asiaticosid can obtain the compound ACE class medicines (ARB+ of 0.05-25% concentration L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+Bulbus Allii Cepae extract+liquaemin+asiaticosid) spraying of anti-scar Agent, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 161 5% (asiaticosid of 3%Ang 1-7+1% triamcinolone acetonide acetates+1%) is anti- The preparation of scar gel
By taking Ang 1-7+ triamcinolone acetonide acetates+asiaticosid as an example：Under room temperature condition, 72g normal saline solutions are weighed, are added Enter 3g Ang 1-7,1g triamcinolone acetonide acetates, 1g asiaticosids fully to dissolve, add 3g sodium carboxymethylcelluloses, 25 DEG C of bars It is swelled overnight under part.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 5% compound ACE class medicines (asiaticosid of 3%Ang 1-7+1% triamcinolone acetonide acetates+1%) anti-anti- scar gel of scar gel.
By change physiological saline and Ang 1-7, triamcinolone acetonide acetate, asiaticosid quality proportioning can obtain 0.05- Compound ACE classes medicine (Ang 1-7, triamcinolone acetonide acetate, asiaticosid) anti-scar gel of 25% concentration, with for inhomogeneity Type scar obtains optimal anti-scar effect.
The compound ACE classes medicine (Bulbus Allii Cepae extract+3% of 3%Ang 1-7+1% asiaticosids+3% of embodiment 162 10% Liquaemin) anti-scar plastics preparation method
By taking Ang 1-7+ asiaticosids+Bulbus Allii Cepae extract+heparin as an example：Weigh 8g polyvinyl alcohol (PVA) and be added to 88ml In distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed.Finally 3g Ang 1-7,1g asiaticosids, 3g Bulbus Allii Cepae extracts and 3g liquaemins are added, is stirred well to and is completely dissolved, be cooled to room Temperature.Encapsulation preserves.
It can be obtained by the quality proportioning for changing plastics matrix and Ang 1-7, asiaticosid, Bulbus Allii Cepae extract and liquaemin To compound ACE classes medicine (Ang 1-7+ asiaticosids+Bulbus Allii Cepae extract+liquaemin) anti-scar film of 0.05-25% concentration Agent, with for different type scar or the optimal anti-scar effect of acquirement.
Embodiment 163 10% compound ACE classes medicine (liquaemin of 2%L-733060+2% Bulbus Allii Cepae extracts+6%) anti-scar
Trace bar cloth pastes preparation method
L-733060+ Bulbus Allii Cepae extracts+liquaemin：In 50 DEG C of waters bath with thermostatic control, 2g L-733060, the extraction of 2g onions are taken Thing, 6g liquaemins, are dissolved in 80g distilled water, and 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peaches are added into the aqueous solution Glue, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added in 4g glycerine, dissolving stirs, and obtains B liquid； Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room temperature.Said medicine is coated with, adherent layer is covered, cuts Block.Above method obtains 10% compound ACE classes medicine (liquaemin of 2%L-733060+2% Bulbus Allii Cepae extracts+6%) anti-scar bar Cloth pastes.
By change bar cloth paste matrix and L-733060, Bulbus Allii Cepae extract, liquaemin quality proportioning can obtain 0.05- The anti-scar bar cloth patch of compound ACE classes medicine (L-733060+ Bulbus Allii Cepae extracts+liquaemin) of 25% concentration, with for inhomogeneity Type scar obtains optimal anti-scar effect.
The compound ACE classes medicine (triamcinolone acetonide acetate of 5%L-733060+5% asiaticosids+15%) of embodiment 164 25% Anti- scar spray preparation method
By taking L-733060+ asiaticosids+triamcinolone acetonide acetate as an example：In 100g physiological saline, 5g L- are added 733060th, 5g asiaticosids and 15g triamcinolone acetonide acetates and 1g urea, are stirred.And it is fitted into spray bottle.
By change spray reclaimed water and L-733060, asiaticosid, triamcinolone acetonide acetate quality proportioning can obtain Compound ACE classes medicine (L-733060+ asiaticosids+triamcinolone acetonide acetate) anti-scar spray of 0.05-25% concentration, with pin To different type scar or obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 165 0.4% (asiaticosids of 0.1%DALBK (or HOE-140)+0.1%+ The Bulbus Allii Cepae extract of 0.1% liquaemin+0.1%) the anti-scar ointment containing urea preparation
With DALBK (or HOE-140)+asiaticosid+liquaemin+Bulbus Allii Cepae extract：By tristearin in 70 DEG C of waters bath with thermostatic control Sour magnesium 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, and heating is melted and stirred as oil phase；70 DEG C of perseverances Take distilled water 32mL to add in 100ml beakers in tepidarium and be heated to 70 DEG C, add urea 10g dissolvings and be used as aqueous phase；Electricity consumption Sub- balance weighs 100mg DALBK (or HOE-140), 100mg asiaticosids, 100mg liquaemins, 100mg Bulbus Allii Cepae extracts, DALBK (or HOE-140), asiaticosid, liquaemin, Bulbus Allii Cepae extract add oil phase dissolving；Finally aqueous phase oil phase is mixed simultaneously It is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 0.4% compound ACE classes medicine (0.1% The Bulbus Allii Cepae extract of+0.1% liquaemin of DALBK (or HOE-140)+0.1% asiaticosid+0.1%) the anti-scar ointment containing urea.
Can by the ratio for changing DALBK (or HOE-140), asiaticosid, liquaemin, Bulbus Allii Cepae extract and ointment bases To obtain the compound ACE classes medicine (ADALBK (or HOE-140)+asiaticosid+liquaemin+onion of 0.05-25% mass fractions Extract) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 166 15% (extract by the onion of 5%DALBK (or HOE-140)+5% liquaemin+5% Thing) the anti-scar ointment containing numerous emulsifiers preparation
By taking DALBK (or HOE-140)+liquaemin+Bulbus Allii Cepae extract as an example：By stearic acid in 70 DEG C of waters bath with thermostatic control 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine 16g, ethylparaben 0.3g are put into 100ml beakers, and heating is melted Change and stir as oil phase；Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g is taken to add in 70 DEG C of waters bath with thermostatic control Enter to be heated to 70 DEG C in 100ml beakers and be well mixed to be used as aqueous phase；With electronic balance weigh 5g DALBK (or HOE-140), 5g Bulbus Allii Cepae extracts and 5g liquaemins, DALBK (or HOE-140), liquaemin and Bulbus Allii Cepae extract add oil phase dissolving；Finally will Aqueous phase oil phase, which is mixed and is sufficiently stirred, is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains 15% compound ACE Class medicine (Bulbus Allii Cepae extract of 5%DALBK (or HOE-140)+5% liquaemin+5%) anti-scar ointment containing numerous emulsifiers.
It can be obtained by the ratio for changing DALBK (or HOE-140), liquaemin, Bulbus Allii Cepae extract and ointment bases The compound ACE classes medicine (DALBK (or HOE-140)+liquaemin+Bulbus Allii Cepae extract) of 0.05-25% mass fractions resists containing urea Scar ointment.
The compound ACE classes medicine (asiaticosid of 3%AcSDKP+9% triamcinolone acetonide acetates+9%) of embodiment 167 21% is anti- The preparation of scar normal saline solution
By taking AcSDKP+ triamcinolone acetonide acetates+asiaticosid as an example：Under room temperature condition, 100g normal saline solutions are weighed, are used Electronic balance weighs 3g AcSDKP, 9g triamcinolone acetonide acetates, 9g asiaticosids and adds in physiological saline and be sufficiently stirred.Encapsulation is protected Deposit.Above method obtains 21% compound ACE classes medicine (asiaticosid of 3%AcSDKP+9% triamcinolone acetonide acetates+9%) anti-scar Normal saline solution.
0.05-25% is can obtain by changing physiological saline and AcSDKP, triamcinolone acetonide acetate, asiaticosid quality proportioning Compound ACE classes medicine (AcSDKP+ triamcinolone acetonide acetates+asiaticosid) anti-scar normal saline solution of concentration, with for not Same type scar obtains optimal anti-scar effect.
The compound ACE classes medicine of embodiment 168 3.5% (asiaticosid of 0.5%AcSDKP+0.5% Bulbus Allii Cepae extracts+1%+ 1.5% liquaemin) anti-scar gel preparation
By taking AcSDKP+ Bulbus Allii Cepae extracts+asiaticosid+liquaemin as an example：Under room temperature condition, it is water-soluble to weigh 72g physiology salts Liquid, add 0.5g AcSDKP, 0.5g Bulbus Allii Cepae extracts, 1g asiaticosids, 1.5g liquaemins and fully dissolve, add 3g carboxylic first Base sodium cellulosate, it is swelled overnight under the conditions of 25 DEG C.It is eventually adding 20ml glycerine and 0.1g fatty acid sorbitans.Above method obtains 3.5% compound ACE classes medicine (liquaemin of+1% asiaticosid of 0.5%AcSDKP+0.5% Bulbus Allii Cepae extracts+1.5%) anti-scar Gel.
By change physiological saline and AcSDKP, Bulbus Allii Cepae extract, asiaticosid, liquaemin quality proportioning can obtain Compound ACE classes medicine (AcSDKP+ Bulbus Allii Cepae extracts+asiaticosid+liquaemin) anti-scar gel of 0.05-25% concentration, with For different type scar or obtain optimal anti-scar effect.
Compound ACE classes medicine (the 0.1%ARB+0.1%L-733060+0.1% liquaemins+0.1% of embodiment 169 0.4% Bulbus Allii Cepae extract) anti-scar plastics preparation method
By taking Telmisartan+L-733060+ liquaemins+Bulbus Allii Cepae extract as an example：8g polyvinyl alcohol (PVA) is weighed to be added to In 88ml distilled water, it is stirred well to and is completely dissolved in 90 DEG C of waters bath with thermostatic control, add 3ml glycerine, stirs to well mixed. 100mg Telmisartans, 100mg L-733060,100mg liquaemins and 100mg Bulbus Allii Cepae extracts are eventually adding, is stirred well to It is completely dissolved, is cooled to room temperature.Encapsulation preserves.
Can by the quality proportioning for changing plastics matrix and Telmisartan, L-733060, liquaemin and Bulbus Allii Cepae extract The anti-scar of compound ACE classes medicine (Telmisartan+L-733060+ liquaemins+Bulbus Allii Cepae extract) for obtaining 0.05-25% concentration applies Film, with for different type scar or the optimal anti-scar effect of acquirement.
Compound ACE classes medicine (the 4%ARB+4%L-733060+4% triamcinolone acetonide acetates+12% of embodiment 170 24%
Asiaticosid) anti-scar bar cloth patch preparation method
By taking Irbesartan+L-733060+ triamcinolone acetonide acetates+asiaticosid as an example：In 50 DEG C of waters bath with thermostatic control, take 4g in distress Bei Shatan, 4g L-733060,4g triamcinolone acetonide acetates and 12g asiaticosids, are dissolved in 80g distilled water, are added into the aqueous solution 2.5g carbomers, 5g glycerine, 2.5g gelatin, 2.5g peach gums, 0.1g EDTA-2Na, obtain A liquid；4g Sodium Polyacrylates separately are taken, are added Into 4g glycerine, dissolving stirs, and obtains B liquid；Finally A, B liquid are mixed and are stirred well to well mixed, is cooled to room Temperature.Said medicine is coated with, covers adherent layer, stripping and slicing.Above method obtains 24% compound ACE class medicines (4%ARB+4%L- The asiaticosid of 733060+4% triamcinolone acetonide acetates+12%) anti-scar bar cloth patch.
The quality proportioning of matrix and Irbesartan, L-733060, triamcinolone acetonide acetate, asiaticosid is pasted by changing bar cloth The compound ACE classes medicine (Irbesartan+L-733060+ triamcinolone acetonide acetates+asiaticosid) that can obtain 0.05-25% concentration is anti- Scar bar cloth pastes, with for different type scar or the optimal anti-scar effect of acquirement.
The compound ACE classes medicine of embodiment 171 0.6% (0.1%ACEI+0.1%L-733060+0.1%DALBK (or HOE-140) the asiaticosid of+0.1% liquaemin of+0.1% Bulbus Allii Cepae extract+0.1%) anti-scar spray preparation method
By taking lisinopril+L-733060+DALBK (or HOE-140)+asiaticosid+Bulbus Allii Cepae extract+liquaemin as an example： In 100g physiological saline, add 100mg lisinoprils, 100mg L-733060,100mg DALBK (or HOE-140), 100mg asiaticosids, 100mg Bulbus Allii Cepae extracts, 100mg liquaemins and 1g urea, are stirred.And load spray bottle In.
By changing spray reclaimed water and lisinopril, L-733060, DALBK (or HOE-140), asiaticosid, onion Extract, the quality proportioning of liquaemin can obtain the compound ACE classes medicine (lisinopril+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+asiaticosid+Bulbus Allii Cepae extract+liquaemin) anti-scar spray, with for different type scar or Obtain optimal anti-scar effect.
The compound ACE classes medicine of embodiment 172 24% (9%ACEI+3%L-733060+6%DALBK (or HOE-140)+ The liquaemin of 3% Bulbus Allii Cepae extract+3%) the anti-scar ointment containing urea preparation
By taking captopril+L-733060+DALBK (or HOE-140)+Bulbus Allii Cepae extract+liquaemin as an example：In 70 DEG C of constant temperature Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers, heating fusing and the work that stirs in water-bath For oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g dissolvings As aqueous phase；9g captoprils, 3g L-733060,6g DALBK (or HOE-140), 3g onions are weighed with electronic balance to extract Thing and 3g liquaemins, captopril, L-733060, DALBK (or HOE-140), Bulbus Allii Cepae extract, liquaemin addition oil phase are molten Solution；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to room temperature, is sealed in 5 DEG C of refrigerators.Above method obtains The 24% compound ACE classes medicine (liver of 9%ACEI+3%L-733060+6%DALBK (or HOE-140)+3% Bulbus Allii Cepae extract+3% Plain sodium) the anti-scar ointment containing urea.
By changing captopril, L-733060, DALBK (or HOE-140), Bulbus Allii Cepae extract, liquaemin and ointment base The ratio of matter can obtain 0.05-25% mass fractions compound ACE classes medicine (captopril+L-733060+DALBK (or HOE-140)+Bulbus Allii Cepae extract+liquaemin) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 173 14% (2%ACEI+6%L-733060+2%DALBK (or HOE-140)+ The asiaticosid of 2% triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea preparation
By taking Ramipril+L-733060+DALBK (or HOE-140)+triamcinolone acetonide acetate+asiaticosid as an example：At 70 DEG C Magnesium stearate 8.5g, white oil 34g, lanolin 14g are put into 100ml beakers in water bath with thermostatic control, heating is melted and stirred It is even to be used as oil phase；Take distilled water 32mL to add in 100ml beakers in 70 DEG C of waters bath with thermostatic control and be heated to 70 DEG C, add urea 10g Dissolving is used as aqueous phase；2g Ramiprils, 6g L-733060,2g DALBK (or HOE-140), 2g acetic acid are weighed with electronic balance Triamcinolone acetonide, 2g asiaticosids, Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, asiaticosid Add oil phase dissolving；The mixing of water oil phase is sufficiently stirred and adds 1ml azones.Continue stirring to room temperature.Sealed storage is in 5 DEG C of refrigerators In.Above method obtains 14% compound ACE classes medicine (2%ACEI+6%L-733060+2%DALBK (or HOE-140)+2% The asiaticosid of triamcinolone acetonide acetate+2%) the anti-scar ointment containing urea.
By changing Ramipril, L-733060, DALBK (or HOE-140), triamcinolone acetonide acetate, asiaticosid and soft The ratio of cream base matter can obtain the compound ACE classes medicine (Ramipril+L-733060+DALBK of 0.05-25% mass fractions (or HOE-140)+triamcinolone acetonide acetate+asiaticosid) the anti-scar ointment containing urea.
The compound ACE classes medicine of embodiment 174 13% (1%ARB+2%L-733060+1%DALBK (or HOE-140)+ The liquaemin of+1% Bulbus Allii Cepae extract of 3%AcSDKP+2%Ang 1-7+2% asiaticosids+1%) the anti-scar containing numerous emulsifiers is soft The preparation of cream
With Valsartan+L-733060+DALBK (or HOE-140)+AcSDKP+Ang 1-7+ asiaticosids+Bulbus Allii Cepae extract Exemplified by+liquaemin：By stearic acid 4.8g, octadecyl alcolol 4g, glycerin monostearate 3g, atoleine in 70 DEG C of waters bath with thermostatic control 16g, ethylparaben 0.3g are put into 100ml beakers, and heating and melting simultaneously stirs as oil phase；Steaming is taken in 70 DEG C of waters bath with thermostatic control Distilled water 60mL, glycerine 10ml, lauryl sodium sulfate 0.6g, which are added in 100ml beakers, to be heated to 70 DEG C and is well mixed to be used as water Phase；1g Valsartans, 2g L-733060,1g DALBK (or HOE-140), 3g AcSDKP, 2g Ang 1- are weighed with electronic balance 7th, 2g asiaticosids, 1g Bulbus Allii Cepae extracts, 1g liquaemins, Valsartan, L-733060, DALBK (HOE-140), AcSDKP, Ang 1-7, asiaticosid, Bulbus Allii Cepae extract, liquaemin add oil phase dissolving；Finally aqueous phase oil phase is mixed and is sufficiently stirred and is cooled to Room temperature, it is sealed in 5 DEG C of refrigerators.Above method obtains 13% compound ACE class medicines (1%ARB+2%L-733060+1% The liquaemin of+1% Bulbus Allii Cepae extract of DALBK (or HOE-140)+3%AcSDKP+2%Ang 1-7+2% asiaticosids+1%) contain The anti-scar ointment of numerous emulsifiers.
By changing Valsartan, L-733060, DALBK (HOE-140), AcSDKP, Ang 1-7, asiaticosid, onion carry The ratio of thing, liquaemin and ointment bases is taken to obtain the compound ACE classes medicine (Valsartan+L- of 0.05-25% mass fractions 733060+DALBK (or HOE-140)+AcSDKP+Ang 1-7+ asiaticosids+Bulbus Allii Cepae extract+liquaemin) contain a variety of emulsifications The anti-scar ointment of agent.
The compound ACE classes medicine of embodiment 175 21% (3%ARB+2%L-733060+1%DALBK (or HOE-140)+ The liquaemin of 3%AcSDKP+6%Ang 1-7+3% Bulbus Allii Cepae extracts+3%) anti-scar normal saline solution preparation
With Telmisartan+L-733060+DALBK (or HOE-140)+AcSDKP+Ang 1-7+ Bulbus Allii Cepae extracts+liquaemin Exemplified by：Under room temperature condition, weigh 100g normal saline solutions, with electronic balance weigh 3g Telmisartans, 2g L-733060, 1gDALBK (or HOE-140), 3g AcSDKP, 6g Ang 1-7,3g Bulbus Allii Cepae extracts, 3g liquaemins, which are added in physiological saline, to be filled Divide stirring.Encapsulation preserves.Above method obtain 21% compound ACE classes medicine (3%ARB+2%L-733060+1%DALBK (or HOE-140) the liquaemin of+3%AcSDKP+6%Ang 1-7+3% Bulbus Allii Cepae extracts+3%) anti-scar normal saline solution.
By change physiological saline and Telmisartan, L-733060, DALBK (or HOE-140), AcSDKP, Ang 1-7, Bulbus Allii Cepae extract, liquaemin quality proportioning can obtain the compound ACE class medicines (ARB+L-733060+ of 0.05-25% concentration DALBK (or HOE-140)+AcSDKP+Ang 1-7+ Bulbus Allii Cepae extracts+liquaemin) anti-scar normal saline solution, with for not Same type scar obtains optimal anti-scar effect.
The detection of each ACE related activities peptide in the mouse scar of embodiment 176
1. experimental method：
(1) experimental subjects：Select C57BL/6 mouse, be divided into 4 groups, respectively K groups be ACE gene knockouts group, R groups be thunder Meter Pu Li groups, H groups are hydralazine group, B groups are blank control group.Wherein K groups use ACE knock out mice, remaining each group It is the wild type with the compatriot's birth of ACE knock out mice.
(2) factor is handled：
After mouse conventinal breeding 3d, in the chloraldurate normal saline solution 0.1ml/10g of intraperitoneal injection 4%, anaesthetize into The hair of dorsal area is cut off after work(with scissors, depilatory cream further removes the hair of mouse back.Using mouse backbone as center line, side is opened Surgically left and right respectively cuts off 1 piece of 2mm × 15mm stringer rectangular slits (Fig. 2) to 4mm.Cage is divided to feed mouse after otch foundation Support, add different medicines respectively in mouse drinking water, wherein B groups feed common drinking water；R groups, which are fed, contains Ramipril The drinking water of (10mg/kg/ days)；H groups feed the drinking water containing hydralazine (40mg/kg/ days)；D groups feed common drinking water.Treat Mouse is put to death after all mouse back operative incision surface scabs come off within postoperative 14 days.Cicatricial tissue, FFPE are cut, row is exempted from Ang II, SP and Ang 1-7 expression quantity in epidemic disease groupization detection tissue；Take part cicatricial tissue ELISA method detection AcSDKP Expression quantity.
2. experimental result：
(1) Ang II ImmunohistochemistryResults Results
Each group ImmunohistochemistryResults Results are shown in Fig. 3, as seen from the figure, the Ang II expression of ACE gene knockouts group and Ramipril group Amount is significantly lower than hydralazine group and blank control group (p<0.05)；But ACE gene knockouts group and Ramipril group difference are without system Meter learns meaning (p>0.05), hydralazine group and blank control group no significant difference (p>0.05).
(2) SP ImmunohistochemistryResults Results
Each group ImmunohistochemistryResults Results are shown in Fig. 4, and as seen from the figure, the SP expression quantity of ACE gene knockouts group and Ramipril group is bright It is aobvious to be higher than hydralazine group and blank control group (p<0.05)；But ACE gene knockouts group and Ramipril group no statistical difference Meaning (p>0.05), hydralazine group and blank control group no significant difference (p>0.05).
(3) Ang 1-7 ImmunohistochemistryResults Results
Each group ImmunohistochemistryResults Results are shown in Fig. 5, as seen from the figure, the Ang 1-7 expression of ACE gene knockouts group and Ramipril group Measure apparently higher than hydralazine group and blank control group (p<0.05)；But ACE gene knockouts group and Ramipril group difference are without system Meter learns meaning (p>0.05), hydralazine group and blank control group no significant difference (p>0.05).
(4) ImmunohistochemistryResults Results
Average gray (average optical density) result using ImageJ software quantitative analyses Ang II, SP and Ang 1-7 is shown in Fig. 6.Ang II expression quantity in ACE gene knockouts group, Ramipril group cicatricial tissue is significantly lower than blank control group and hydrazine benzene Pyridazine group (p<0.05), and SP and Ang 1-7 expression quantity is apparently higher than blank control group and hydralazine group (p<0.05).
(4) AcSDKP ELISA experimental results
Each group ELISA experimental results are shown in Fig. 7.The AcSDKP expression quantity of ACE gene knockouts group and Ramipril group is substantially high In hydralazine group and blank control group (p<0.05)；But ACE gene knockouts group and Ramipril group no significant difference (p>0.05), hydralazine group and blank control group no significant difference (p>0.05).
3. experiment conclusion：
(1) ACE is blocked to reduce cicatricial tissue Ang II expression by way of medicine or gene knockout.
(2) ACE is blocked to increase cicatricial tissue SP, Ang 1-7 and AcSDKP by way of medicine or gene knockout Expression.
The optium concentration of embodiment 177ACE related activities peptide/inhibitor (ACE classes medicine) stimulated in vitro
1. experimental method：
Using the DMEM cell culture fluid culture NIH 3T3 l cells containing 10%FBS, (fibroblast is The ultimate effector cell of cicatrization, other cells and factor are all finally by influenceing wound to fibroblastic effect Healing), but FBS was reduced to 1% to reduce the influence of various albumen in serum as far as possible in 24 hours before detection.Will NIH 3T3 fibroblasts (DMEM containing 1%FBS) are transferred to 96 orifice plates, and adding 1ng/ml TGF-βs 1 stimulates (TGF-β 1 It is the strong rush fibrosis factor, adding the restructuring TGF-β 1 of external source stimulates cell to simulate wound stimulation) pierced with simulating wound Swash；The Ang II, SP, AcSDKP, Ang1-7 and bradykinin of at least 3 various concentrations (10 times are incremented by) are separately added into simultaneously, with And respective inhibitor (or antagonist) and ACE inhibitor.48 hours, using CCK-8 methods (CellCounting Kit-8, Dojindo, Japan) detection cell proliferative conditions.
According to the action principle of each medicine, if selected medicine plays a driving role in NIH3T3 cells propagation, more No cytotoxicity is selected in individual concentration, promotes the optimal least concentration of cell cultivation effect as optium concentration；If selected medicine Inhibitory action is played in NIH3T3 cells propagation, then no cytotoxicity is selected in multiple concentration, suppresses cell cultivation effect most Good least concentration is as optium concentration.
2. experimental result
Experimental result is shown in Table 1.
The optium concentration of the ACE related activities peptide of table 1 and inhibitor stimulated in vitro
Biologically active peptide Optium concentration Inhibitor Optium concentration
AngII 10nM Losartan 100μM
SP 100nM L-733060 1μM
Ang1-7 10nM A779 10μM
AcSDKP 1×10-4mg/ml S-17092 1×10-2mg/ml
Bradykinin 1nM DALBK 10nM
HOE-140 100nM
Lisinopril 10μM
The ACE class drug influence NIH 3T3 cells of embodiment 178 are bred and the experimental study of collagen
The final result of cicatrization shows hyperblastosis and collagen deposition in vivo, then finally shows thin in vitro Born of the same parents breed and collagen production.
1. experimental method：
Using the DMEM cell culture fluid culture NIH 3T3 l cells containing 10%FBS, but before detection FBS was reduced to 1% influence for having reduced various albumen in serum as far as possible in 24 hours.1ng/ml TGF-βs 1 are added to simulate Wound stimulates；While Ang II are separately added into, SP, AcSDKP, Ang 1-7 and bradykinin, and respective inhibitor (or antagonism Agent) and ACE inhibitor, the concentration of each active peptide and inhibitor (or antagonist) is all optimal dense in above-described embodiment Degree；After culture 48 hours, using CCK-8 methods (Cell Counting Kit-8, Dojindo, Japan) detection cell propagation feelings Condition, the collagen egg in nutrient solution is detected with Sirius Red Collagen Detection Kit (Chondres Inc.USA) White concentration.Above-mentioned every kind of ACE classes medicine does 6 repetitions, and the data of acquisition carry out single factor test using the SPSS19.0 of IBM Corporation Variance analysis, compare two-by-two using LSD methods, p<0.05 thinks statistically significant.
2. experimental result：
Cell proliferative conditions are shown in Fig. 8.Because cell proliferative conditions repeated detection, condition slightly has difference, but detects every time Contain blank control group (containing 1ng/ml TGF-βs 1), therefore be standardized with the group, i.e., by blank control group Absorbance values are all standardized as 1.Ang II, SP, A799, S-17902 and bradykinin play the role of to promote cell propagation；Its In, Ang II promote the best results (p of NIH3T3 propagation<0.05), SP, A799, S-17902 and bradykinin compare no system two-by-two Meter learns meaning (p>0.05).Losartan, L-733060, Ang 1-7, AcSDKP, 2 kinds of brad ykinin antagonists (DALBK and HOE- 140) and Lisinopril can suppress cell propagation, wherein Losartan, L-733060 and Lisinopril inhibition compared with Ang 1-7, AcSDKP and 2 kinds of brad ykinin antagonists more preferably (p<0.01), but the difference between former three between rear four Not statistically significant (p>0.05).
Collagen generation situation is shown in Fig. 9.Ang II, SP, A799, S-17902 and bradykinin can promote collagen to generate；Its In, Ang II promote the collagenogenic best results (p of NIH3T3<0.05), SP, A799, S-17902 and bradykinin compare two-by-two Not statistically significant (p>0.05).Losartan, L-733060, Ang 1-7, AcSDKP, 2 kinds of brad ykinin antagonists and Lisinopril can suppress collagen generation, and wherein Losartan, L-733060 and Lisinopril inhibition are compared with Ang 1- 7th, AcSDKP and 2 kinds of brad ykinin antagonists more preferably (p<0.01), but the difference between former three between rear four is without system Meter learns meaning (p>0.05).
3. experiment conclusion：
This experimental study ACE classes medicine promotion to cicatrization or inhibitory action in vitro.Wherein, Losartan, L-733060, Ang 1-7, AcSDKP, 2 kinds of brad ykinin antagonists (DALBK and HOE-140) and Lisinopril can suppress into fibre Cytoactive is tieed up, Losartan, L-733060 and Lisinopril inhibition are compared with Ang 1-7, AcSDKP and 2 kinds of bradykinins Antagonist is more preferably.

Claims (9)

1. a kind of anti-cicatrix externally used preparation of compound Angiotensin-Converting class, it is characterised in that tight by one or more blood vessels Element conversion enzyme drug and other one or more anti-scarring drug active ingredients form, and the quality of active ingredient is dense in preparation Spend for 0.05%-25%.
A kind of 2. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that The Angiotensin-Converting class choice of drug ARB, N- acetyl group-seryl-aspartoyls- Lysyl-proline, hypertensin 1-7, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 antagonist, brad ykinin antagonists and Angiotensin-Converting suppress Agent；Wherein, ARB is selected from Losartan, Irbesartan, Valsartan, Telmisartan, Olmesartan, candy Sha Tan；Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 antagonist is selected from L-733060；Brad ykinin antagonists are selected from DALBK and HOE-140；Angiotensin-Converting Inhibitor is selected from lisinopril, Ramipril, captopril, Cilazapril, enalapril, benazepil.
A kind of 3. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that Other described anti-scarring drugs are from Triamcinolone acetonide, heparin, Bulbus Allii Cepae extract, asiaticosid.
A kind of 4. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that A variety of Angiotensin-Converting class effective ingredient combinations are：(1) ARB combines with ACEI, quality proportioning 0.33- 3:0.33-3；(2) ARB and SP antagonist-combination, quality proportioning 0.33-3:0.33-3；(3) ACEI and SP antagonist, The antagonist-combination of bradykinin, quality proportioning 0.33-3:0.33-3:0.33-3；(4) ARB combines SP antagonist, bradykinin Antagonist-combination, quality proportioning 0.33-3:0.33-3:0.33-3；(5) ARB combines SP antagonist, the antagonism of bradykinin Agent, and N- acetyl group-seryl-aspartoyl-lysyl-proline, hypertensin 1-7 combine, and quality proportioning is 0.33-3:0.33-3:0.33-3:0.33-3:0.33-3。
A kind of 5. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that Various other anti-scarring drug combination of active principles modes are：(1) Triamcinolone acetonide is combined with heparin, Bulbus Allii Cepae extract, and quality is matched somebody with somebody Than for 0.33-3:0.33-3:0.33-3；(2) Triamcinolone acetonide combines with asiaticosid, quality proportioning 0.33-3:0.33-3； (3) Bulbus Allii Cepae extract, heparin combine with asiaticosid, quality proportioning 0.33-3:0.33-3:0.33-3；(4) Triamcinolone acetonide with Bulbus Allii Cepae extract, heparin and asiaticosid combination, quality proportioning 0.33-3:0.33-3:0.33-3:0.33-3；(5) heparin with Bulbus Allii Cepae extract combines, quality proportioning 0.33-3:0.33-3.
A kind of 6. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that When being combined by multi-medicament active principle, the matter such as it is transferred on the mass mixings such as each group is divided into, or the quality of any of which component 3 times of highest during amount or minimum 1/3 times when the quality such as being adjusted downward to.
A kind of 7. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that The formulation of described preparation be solution, pulvis, lotion, liniment, finish, emulsion containing creme, ointment containing emulsifiable paste, paste, plaster, Gel, plastics, aerosol or spray, emplastrum, other formulations etc..
A kind of 8. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 7, it is characterised in that Solution is tincture and spirit, and emplastrum is rubber ointment, Babu plaster, bar cloth patch, and other are to be dissolved in dimethyl sulfoxide (DMSO) Formulation.
A kind of 9. anti-cicatrix externally used preparation of compound Angiotensin-Converting class according to claim 1, it is characterised in that The preparation needs aseptic process.
CN201710842474.4A 2017-09-18 2017-09-18 The anti-cicatrix externally used preparation of compound Angiotensin-Converting class Pending CN107648611A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710842474.4A CN107648611A (en) 2017-09-18 2017-09-18 The anti-cicatrix externally used preparation of compound Angiotensin-Converting class

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710842474.4A CN107648611A (en) 2017-09-18 2017-09-18 The anti-cicatrix externally used preparation of compound Angiotensin-Converting class

Publications (1)

Publication Number Publication Date
CN107648611A true CN107648611A (en) 2018-02-02

Family

ID=61130262

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710842474.4A Pending CN107648611A (en) 2017-09-18 2017-09-18 The anti-cicatrix externally used preparation of compound Angiotensin-Converting class

Country Status (1)

Country Link
CN (1) CN107648611A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108245628A (en) * 2018-02-11 2018-07-06 浙江大学 Compound chitosan skin repair preparation containing hypertensinⅡreceptorretarder
CN108245661A (en) * 2018-02-11 2018-07-06 浙江大学 Compound chitosan skin repair preparation containing angiotensin converting enzyme inhibitor
CN110302414A (en) * 2019-08-20 2019-10-08 广西信业生物技术有限公司 A kind of medical scar repairs silicone gel dressing and preparation method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1230122A (en) * 1996-07-15 1999-09-29 三共株式会社 Medical compsns.
CN1668312A (en) * 2002-05-13 2005-09-14 洛杉矶儿童医院 Treatment and prevention of abnormal scar formation in keloids and other cutaneous or internal wounds or lesions
CN102335167A (en) * 2010-07-28 2012-02-01 中国医学科学院整形外科医院 Application of captopril to inhibition of scar hyperplasia
CN103432145A (en) * 2013-07-01 2013-12-11 宁夏医科大学 Scar treatment external application western medicine composition preparation and application thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1230122A (en) * 1996-07-15 1999-09-29 三共株式会社 Medical compsns.
CN1668312A (en) * 2002-05-13 2005-09-14 洛杉矶儿童医院 Treatment and prevention of abnormal scar formation in keloids and other cutaneous or internal wounds or lesions
CN102335167A (en) * 2010-07-28 2012-02-01 中国医学科学院整形外科医院 Application of captopril to inhibition of scar hyperplasia
CN103432145A (en) * 2013-07-01 2013-12-11 宁夏医科大学 Scar treatment external application western medicine composition preparation and application thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HAKAN UZUN等: "Angiotensin-converting enzyme inhibitor enalapril reduces formation of hypertrophic scars in a rabbit ear wounding model", 《PLASTIC AND RECONSTRUCTIVE SURGERY》 *
KIYOSHI MORIHARA等: "Cutaneous tissue angiotensineconverting enzyme may participate in pathologic scar formation in human skin", 《J. AM. ACAD. DERMATOL.》 *
刘宏伟等: "增生性瘢痕中血管紧张素转化酶表达及血管紧张素II产生的变化", 《中国美容医学》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108245628A (en) * 2018-02-11 2018-07-06 浙江大学 Compound chitosan skin repair preparation containing hypertensinⅡreceptorretarder
CN108245661A (en) * 2018-02-11 2018-07-06 浙江大学 Compound chitosan skin repair preparation containing angiotensin converting enzyme inhibitor
CN110302414A (en) * 2019-08-20 2019-10-08 广西信业生物技术有限公司 A kind of medical scar repairs silicone gel dressing and preparation method

Similar Documents

Publication Publication Date Title
Timmermans et al. Angiotensin II receptor subtypes: selective antagonists and functional correlates
Jiang et al. Ibrutinib promotes atrial fibrillation by inducing structural remodeling and calcium dysregulation in the atrium
Meng et al. Hydrogen sulfide donor GYY4137 protects against myocardial fibrosis
Sunagawa et al. A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infarction in rats
Wang et al. Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK
DE60202727T2 (en) Inhibition of histone deacetylase for the treatment of cardiac hypertrophy
Kim et al. Effects of ACE2 inhibition in the post-myocardial infarction heart
Choudhary et al. All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system
AU2008267227B2 (en) Treatment of heart failure in non-human animal mammals by an aldosterone antagonist
KR20030009454A (en) SKIN TISSUE REGENERATION PROMOTERS COMPRISING GINSENOSIDE Rb1
CN107648611A (en) The anti-cicatrix externally used preparation of compound Angiotensin-Converting class
CN101433717A (en) Drugs containing chymase inhibitor and ACE inhibitor as the active ingredients
Wu et al. Andrographolide protects against aortic banding-induced experimental cardiac hypertrophy by inhibiting MAPKs signaling
EP4023227A1 (en) Pharmaceutical composition and application thereof
Yang et al. Effects of Wenxin Keli on cardiac hypertrophy and arrhythmia via regulation of the calcium/calmodulin dependent kinase II signaling pathway
Hirose et al. The effects of dipeptidyl peptidase-4 on cardiac fibrosis in pressure overload-induced heart failure
Lay et al. Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis
CN103687593A (en) Use of cathepsin k inhibition for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure
Xia et al. Adenosine A2a receptor regulates autophagy flux and apoptosis to alleviate ischemia-reperfusion injury via the cAMP/PKA signaling pathway
Stüdeli et al. Diastolic dysfunction in human cardiac allografts is related with reduced SERCA2a gene expression
Reyes et al. Angiotensin-(1–12)/chymase axis modulates cardiomyocyte L-type calcium currents in rats expressing human angiotensinogen
Javan et al. Interleukin-1 Receptor Antagonism abrogates acute pressure overload-induced murine heart failure
CN107617107A (en) A kind of anti-scar preparation of compound Angiotensin-Converting class
CN107617106A (en) A kind of anti-scar preparation of Angiotensin-Converting class
Zhang et al. Intramyocardial injection of tannic acid attenuates postinfarction remodeling: a novel approach to stabilize the breaking extracellular matrix

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20180202