CN107646885A - A kind of sterilized eliminating smell agent and preparation method thereof - Google Patents
A kind of sterilized eliminating smell agent and preparation method thereof Download PDFInfo
- Publication number
- CN107646885A CN107646885A CN201710665905.4A CN201710665905A CN107646885A CN 107646885 A CN107646885 A CN 107646885A CN 201710665905 A CN201710665905 A CN 201710665905A CN 107646885 A CN107646885 A CN 107646885A
- Authority
- CN
- China
- Prior art keywords
- parts
- sterilized
- tertiary amine
- eliminating smell
- medical stone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/01—Deodorant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/01—Deodorant compositions
- A61L9/013—Deodorant compositions containing animal or plant extracts, or vegetable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/01—Deodorant compositions
- A61L9/014—Deodorant compositions containing sorbent material, e.g. activated carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
- A61L2209/20—Method-related aspects
- A61L2209/21—Use of chemical compounds for treating air or the like
Abstract
The present invention provides a kind of sterilized eliminating smell agent, it is characterised in that calculates by weight, the sterilized eliminating smell agent includes：Modified 30 50 parts of medical stone, 5 13 parts of modified silicon rubber powder, 2 15 parts of plant extracts, 0.5 3 parts of neopelex, 0.5 2 parts of tea tree ethereal oil, 30 60 parts of deionized water, 0.1 5 parts of lauric monoglyceride, 0.5 2 parts of dodecyl dimethyl benzyl ammonium bromide, 30 55 parts of ethanol；Wherein, the plant extracts includes mint extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is that nano medical stone is grafted bi-quaternary ammonium salt, and the modified silicon rubber powder is the silica white loading nano silvery, and the ethanol is the ethanol water that mass fraction is 60%.
Description
Technical field
The present invention relates to family's product technique field, in particular it relates to a kind of sterilized eliminating smell agent and its system
Preparation Method.
Background technology
In people in life, more than 80% time is spent indoors.Infant, the old,weak,sick and disabled crowd stop indoors
The time stayed is longer.Food necessary to air is the mankind.Indoor air quality monitoring is reported according to Chinese Medical Association's organizes expert
Show, in various public places, by influenza, respiratory passage infectious disease patients, the sputum for the patient that carries disease germs, cough, spray
Sneeze a variety of germs such as the influenza virus, tubercle bacillus, streptococcus of pollution spread, the phenomenon it occur frequently that group is caught an illness, to family
Life and social activities bring more troubles, have a strong impact on the health of people.
At present, in refrigerator, refrigerator-freezer, the meat safe in shop or toilet, reception room, office, automobile, often place
Stink-removing sterilizer, wherein being typically all placed with activated carbon deodorizing and sterilizing agent, it adsorbs the material for removing and having peculiar smell from air, and has
Sterilizing ability.But its adsorption efficiency is low, sterilization capability is not strong and by such environmental effects.
Therefore, in view of the above-mentioned problems, the present invention provides a kind of sterilized eliminating smell agent, its can kill Staphylococcus aureus,
Escherichia coli, pseudomonas aeruginosa, shigella dysenteriae and white read the various bacterias such as coccobacillus, and adsorption capacity and sterilization capability are excellent,
Sterilization sterilizing, anti-corrosion with high intensity, fresh-keeping and function of odor removal；Sterilized eliminating smell agent provided by the invention it is also sprayable in
The surface of various containers, prevents microbial growth in glass, ceramic utensil, construction material, plastic products and food industry.
The content of the invention
In order to solve the above problems, first aspect present invention provides a kind of sterilized eliminating smell agent, by weight
Calculate, the sterilized eliminating smell agent includes：Modified medical stone 30-50 parts, modified silicon rubber powder 5-13 parts, plant extracts 2-15
Part, neopelex 0.5-3 parts, tea tree ethereal oil 0.5-2 parts, deionized water 30-60 parts, lauric monoglyceride
0.1-5 parts, dodecyl dimethyl benzyl ammonium bromide 0.5-2 parts, ethanol 30-55 parts；
Wherein, the plant extracts includes mint extract, pot marigold extract, orange peel extract, honeysuckle extraction
Thing；The modified medical stone is that nano medical stone is grafted bi-quaternary ammonium salt, and the modified silicon rubber powder is that the silica white loads nanometer
Silver, the ethanol are the ethanol water that mass fraction is 60%.
In one embodiment, calculate by weight, the sterilized eliminating smell agent includes：Modified medical stone 35-45
Part, modified silicon rubber powder 8-12 parts, plant extracts 2-10 parts, neopelex 0.5-2 parts, tea tree ethereal oil 0.5-2 parts, go
Ionized water 40-50 parts, lauric monoglyceride 1-5 parts, dodecyl dimethyl benzyl ammonium bromide 0.5-2 parts, ethanol 40-55 parts.
In one embodiment, calculate by weight, the sterilized eliminating smell agent includes：Modified 42 parts of medical stone,
9 parts of modified silicon rubber powder, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, deionized water 46 part, month
2 parts of cinnamic acid monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol.
In one embodiment, mint extract described in the plant extracts and the pot marigold extract, institute
State orange peel extract, the weight ratio of the Honegsukle flower P.E is 1：(0.5-1)：(1-6)：(2-5).
In one embodiment, mint extract described in the plant extracts and the pot marigold extract, institute
State orange peel extract, the weight ratio of the Honegsukle flower P.E is 1：0.8：4：3.
In one embodiment, bi-quaternary ammonium salt described in the modified medical stone is bi-quaternary ammonium salt containing imidazolyl heterocycle, institute
Stating the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle includes metronidazole, epoxychloropropane, long-chain
Alkyl tertiary amine.
In one embodiment, the long-chain alkyl tertiary amine includes Dodecyl Dimethyl Amine, dodecyldimethylamine
One or more in base tertiary amine, hexadecyldimethyl benzyl ammonium tertiary amine, dodecylbenzyl methyl tertiary amine.
In one embodiment, the long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl first
Base tertiary amine.
In one embodiment, dodecyldimethylamine base tertiary amine described in the long-chain alkyl tertiary amine and the dodecane
The weight ratio of base benzyl methyl tertiary amine is 1：(0.1-0.6).
Another aspect of the present invention provides a kind of preparation method of sterilized eliminating smell agent, comprises the following steps：
(1) modified silicon rubber powder, neopelex are added by weight into reactor, lauric monoglyceride,
Stir, 1h is stirred after being warming up to 40-50 DEG C, 50 DEG C are dried under reduced pressure 8h；
(2) modified medical stone, deionized water, dodecyl dimethyl benzyl bromine are added in mixture into step (1)
Change ammonium, dried after stirring；
(3) it is 60% tea tree ethereal oil, plant extracts and mass fraction to be added in the particle dried into step (2)
Ethanol water, is stirred well mixed, obtains the sterilized eliminating smell agent.
The above-mentioned of the application and other features, aspect and advantage is more readily understood with reference to described further below.
Embodiment
Participate in the election of the detailed description of the invention below for being preferable to carry out method and including embodiment this hair can be more easily understood
Bright content.Unless otherwise defined, all technologies used herein and scientific terminology have common with art of the present invention
The identical implication that technical staff is generally understood that.When contradiction be present, the definition in this specification is defined.
As used herein term " by ... prepare " it is synonymous with "comprising".Term "comprising" used herein, " comprising ",
" having ", " containing " or its any other deformation, it is intended that cover including for non-exclusionism.For example, the combination comprising listed elements
Thing, step, method, product or device are not necessarily limited to those key elements, but can include not expressly listed other key elements or
Such a composition, step, method, product or the intrinsic key element of device.
Conjunction " Consists of " excludes any key element do not pointed out, step or component.If be used in claim, this
Phrase will make claim be closed, it is not included the material in addition to the material of those descriptions, but relative normal
Except rule impurity.When being rather than immediately following in the clause that phrase " Consists of " appears in claim main body after theme,
It is only limited to the key element described in the clause；Other key elements are not excluded outside the claim as entirety.
Equivalent, concentration or other values or parameter are excellent with scope, preferred scope or a series of upper limit preferred values and lower limit
During the Range Representation that choosing value limits, this, which is appreciated that, specifically discloses by any range limit or preferred value and any scope
All scopes that any pairing of lower limit or preferred value is formed, regardless of whether the scope separately discloses.For example, when open
During scope " 1 to 5 ", described scope should be interpreted as including scope " 1 to 4 ", " 1 to 3 ", " 1 to 2 ", " 1 to 2 and 4 to
5 ", " 1 to 3 and 5 " etc..When number range is described herein, unless otherwise indicated, otherwise the scope is intended to include its end
Value and all integers and fraction within the range.
Singulative includes plural number and object is discussed, unless the context clearly dictates otherwise." optional " or it is " any
It is a kind of " refer to that the item that describes thereafter or event may or may not occur, and the description include situation that event occurs and
The situation that event does not occur.
Approximate term in specification and claims is used for modifying quantity, and it is specific to represent that the present invention is not limited to this
Quantity, include the part of the amendment of the acceptable change without cause related basic function close to the quantity.Phase
Answer, modify a numerical value with " about ", " about " etc., mean that the invention is not restricted to the exact numerical.It is approximate in some examples
Term likely corresponds to the precision of the instrument of measured value.In present specification and claims, scope limits can be with
Combine and/or exchange, these scopes include all subranges contained therebetween if not stated otherwise.
In addition, indefinite article " one kind " before key element of the present invention or component and "one" to key element or the quantitative requirement of component
(i.e. occurrence number) unrestriction.Therefore "one" or " one kind " should be read as including one or at least one, and odd number
The key element or component of form also include plural form, unless the obvious purport of the quantity refers to singulative.
" polymer " means by the polymerizable compound prepared by the monomer that polymerize identical or different type.Generic term
" polymer " includes term " homopolymer ", " copolymer ", " terpolymer " and " EVA ".
" EVA " means the polymer prepared by polymerizeing at least two different monomers.Generic term " EVA " includes
(its is general with term " terpolymer " for term " copolymer " (its typically to refer to the polymer prepared by two kinds of different monomers)
To refer to the polymer prepared by three kinds of different monomers).It is also included by polymerizeing more kinds of monomers the polymer that manufactures.
" blend " means that two or more polymer mixes the polymer to be formed by physics or chemical method jointly.
First aspect present invention provides a kind of sterilized eliminating smell agent, calculates by weight, described sterilized to remove
Taste agent includes：Modified medical stone 30-50 parts, modified silicon rubber powder 5-13 parts, plant extracts 2-15 parts, neopelex
0.5-3 parts, tea tree ethereal oil 0.5-2 parts, deionized water 30-60 parts, lauric monoglyceride 0.1-5 parts, dodecyl dimethyl
Benzyl ammonium bromide 0.5-2 parts, ethanol 30-55 parts；
Wherein, the plant extracts includes mint extract, pot marigold extract, orange peel extract, honeysuckle extraction
Thing；The modified medical stone is that nano medical stone is grafted bi-quaternary ammonium salt, and the modified silicon rubber powder is that the silica white loads nanometer
Silver, the ethanol are the ethanol water that mass fraction is 60%.
In one embodiment, calculate by weight, the sterilized eliminating smell agent includes：Modified medical stone 35-45
Part, modified silicon rubber powder 8-12 parts, plant extracts 2-10 parts, neopelex 0.5-2 parts, tea tree ethereal oil 0.5-2
Part, deionized water 40-50 parts, lauric monoglyceride 1-5 parts, dodecyl dimethyl benzyl ammonium bromide 0.5-2 parts, ethanol
40-55 parts.
In one embodiment, calculate by weight, the sterilized eliminating smell agent includes：Modified 42 parts of medical stone,
9 parts of modified silicon rubber powder, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, deionized water 46 part, month
2 parts of cinnamic acid monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol.
In one embodiment, mint extract described in the plant extracts and the pot marigold extract, institute
State orange peel extract, the weight ratio of the Honegsukle flower P.E is 1：(0.5-1)：(1-6)：(2-5).
In one embodiment, mint extract described in the plant extracts and the pot marigold extract, institute
State orange peel extract, the weight ratio of the Honegsukle flower P.E is 1：0.8：4：3.
Mint extract
Peppermint alias be thin severe, greenbrier Lin, Wu's greenbrier Lin, southern peppermint, thin severe, the rising Yang dish of cat, thin Ke, Bo lotus, night breath flower,
It is thin severe, night breath medicine of the Bo lotus of thin severe, Wu's the Bo lotus of thin severe, wild mint, rising Yang dish, Ren Dancao, JIANZHONGXIAO, the beneficial mother of water, Sambucus thunbergiana, native peppermint, with sweet and sour flavor
Grass, herba elsholtziae；Efficacy effect：Dispelling wind, radiating, ward off dirty, removing toxic substances.Affection of exogenous wind-heat is controlled, is had a headache, hot eyes, abscess of throat, food stagnation gas
It is swollen, aphtha, toothache, sore scabies, urticaria；Menthol and peppermint oil dementholized have special fragrant, pungent sense and cool feeling, are mainly used in tooth
Cream, food, tobacco, wine, cold drink, cosmetics, the perfuming of perfumed soap；Wind dispelling, anti-corrosion, anti-inflammatory, town are widely used in medicine
In the medicines such as bitterly, antipruritic, stomach invigorating.All herbal medicine, it is pungent, it is cool.Return lung, Liver Channel, there is diverging wind-heat, clearing throat, promoting eruption removing toxic substances, dredge
Liver solution is strongly fragrant and antipruritic and other effects, suitable for cold, fever, headache, abscess of throat, lossless, wind-fire red eye, rubella, skin itch,
The diseases such as colic, diarrhea and scrofula, external application have slight analgesic effect, for neuralgia etc..
The extracting method of mint extract：Peppermint (herb) that will be clean is added in reactor, add 12 times of quality go from
Sub- water, steam distillation 10h is carried out, obtains peppermint oil crude product；Peppermint oil crude product is freezed into 12h under the conditions of -10 DEG C, obtained thin
Lotus oil and menthol crude product 1；Then water will be distilled off under peppermint oil normal temperature, 24h is freezed under the conditions of -20 DEG C, is obtained thin
Lotus alcohol crude product 2, merge menthol crude product 1 and menthol crude product 2, heating melting, slow cooling is protected to 0 DEG C after complete melting
Warm 2h, filtering, 40 DEG C are dried under reduced pressure, and obtain mint extract.
Pot marigold extract
Pot marigold alias is pot marigold, gold small cup, long-living chrysanthemum, flower of sobering up, asphodel, golden small cup etc.；Pot marigold nature and flavor are light flat,
Flower, leaf have anti-inflammatory, antibacterial action.The root energy promoting flow of qi and blood circulation, flower can cool blood, hemostasis.Europe it is among the people it is outer for skin, mucous membrane it is various
Inflammation, can also the various inflammation of orally taken for curing and ulcer.
The extracting method of pot marigold extract：The n-hexane that 10 times of weight is added into the pot marigold of cleaning carries out closed surpass
Sound extracts, and condition is：0.1-10MPa, time 6h, temperature is at 60 DEG C, and after filtering, extract is concentrated under reduced pressure, and carries out low temperature and does
It is dry, obtain pot marigold extract.
Orange peel extract
Orange peel alias is orange peel, expensive old, red skin, yellow orange peel, wide orange peel, PERICARPIUM CITRI RETICULATAE, orange peel, citrus chachiensis hortorum.Efficacy effect：Reason
Gas invigorating the spleen, it is eliminating dampness and eliminating phlegm.Vomited and diarrhoea for deficiency of food, coughing with a lot of sputum.
The extracting method of orange peel extract：The deionized water that 10 times of weight is added into dry orange peel decoct 2 times,
Then decocting liquid is concentrated under reduced pressure into dry, obtains concentrate, by concentrate by polyamide column, successively with deionized water, quality point
Count the ethanol water punching that the ethanol water for 10%, the ethanol water that mass fraction is 25%, mass fraction are 35%
After washing, then eluted with the ethanol water that mass fraction is 50%, collect eluent, the eluent that is concentrated under reduced pressure is to Dalai's energy
Enough solids separate out, filtering, elute filter cake with absolute ethyl alcohol, obtain orange peel extract.
Honegsukle flower P.E
Honeysuckle alias honeysuckle flower, honeysuckle, two flowers, two precious flowers, honeysuckle flowers, little egret flower, Su Hua, golden flower, golden rattan, double buds
Flower, mountain gold honeysuckle flower, native honeysuckle, wild honeysuckle；Efficacy effect：It is clearing heat and detoxicating, main warm disease heating；Toxic-heat and blood stasis；Carbuncle swells furunculosis；Larynx numbness
And multi-infection disease；The effects such as honeysuckle has antibacterial, antiviral, anti-inflammatory, antipyretic, regulation is immune.
The extracting method of Honegsukle flower P.E：The deionized water of honeysuckle, 10 times of weight is subjected to decocting and boils 2 times, then
Decocting liquid is concentrated under reduced pressure into the 1/3 of decocting liquid original volume, be slowly added to mass fraction be 20% aqua calcis, regulation pH to
10, filtering, absolute ethyl alcohol is added into filter cake, stirred, the sulphur acid for adjusting pH that dropwise addition mass fraction is 50% to 3, stir 0.5h,
Filtering, the pH to 6 of filtrate is adjusted with 1mol/L sodium hydroxide solution, is concentrated under reduced pressure, obtains concentrate；3 are added into concentrate
The deionized water of times weight, extracted, depressurized to 2, then with ethyl acetate with 1mol/L salt acid for adjusting pH after stirring
Ethyl acetate layer is concentrated, ether is added and is stirred 2h, filter, 40 DEG C are dried under reduced pressure 10h, obtain Honegsukle flower P.E.
In one embodiment, bi-quaternary ammonium salt described in the modified medical stone is bi-quaternary ammonium salt containing imidazolyl heterocycle, institute
Stating the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle includes metronidazole, epoxychloropropane, long-chain
Alkyl tertiary amine.
In one embodiment, the long-chain alkyl tertiary amine includes Dodecyl Dimethyl Amine, dodecyldimethylamine
One or more in base tertiary amine, hexadecyldimethyl benzyl ammonium tertiary amine, dodecylbenzyl methyl tertiary amine.
In one embodiment, the long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl first
Base tertiary amine.
In one embodiment, dodecyldimethylamine base tertiary amine described in the long-chain alkyl tertiary amine and the dodecane
The weight ratio of base benzyl methyl tertiary amine is 1：(0.1-0.6)；Preferably, dodecyldimethylamine described in the long-chain alkyl tertiary amine
The weight ratio of base tertiary amine and the dodecylbenzyl methyl tertiary amine is 1：0.24.
The preparation method of the bi-quaternary ammonium salt containing imidazolyl heterocycle comprises the following steps：
Epoxychloropropane is added to reactor, 75 DEG C is warming up to, long-chain alkyl tertiary amine is slowly added dropwise, after being added dropwise, stir
0.5h is mixed, is cooled to 55 DEG C, adds acetonitrile, then divides 3 addition 1- ethoxy -2- methyl -5- nitroimidazoles, insulation reaction
8h, room temperature is cooled to, be concentrated under reduced pressure, obtain the crude product of bi-quaternary ammonium salt containing imidazolyl heterocycle, added acetone stirring 0.5h, be concentrated under reduced pressure, obtain
Bi-quaternary ammonium salt containing imidazolyl heterocycle；The epoxychloropropane and the long-chain alkyl tertiary amine, the 1- ethoxys -2- methyl -5- nitre
The mol ratio of base imidazoles is 1：0.56：0.6；The weight ratio of the epoxychloropropane and the acetonitrile, the acetone is 1：6：4.
The preparation method of the modified medical stone comprises the following steps：
Nano medical stone, acetone are added into reactor, after stirring, adds 2mol/L sodium hydrate aqueous solution,
Stir, alkalize 3-4h at a temperature of 50 DEG C, the bi-quaternary ammonium salt containing imidazolyl heterocycle of synthesis is then added portionwise, under the conditions of 50-60 DEG C
10h is reacted, after reaction terminates, is cooled to room temperature, filters, filter cake is washed with deionized 3-4 times, again with methanol elution, 40
DEG C 12h is dried under reduced pressure, obtains the modified medical stone；The nano medical stone and the acetone, the sodium hydroxide of the 2mol/L
The aqueous solution, the weight ratio of the bi-quaternary ammonium salt containing imidazolyl heterocycle are 1：5：4：0.4.
Mineral in medical stone all have perfect crystal structure, and its networked pore structures being evenly distributed, surface holes are generally
Open bore, internal holes have interconnected pores, blind hole and semiclosed hole, and the diameter of its hole is about in 10nm or so.Medical stone is to a system
Row organic compound has a certain amount of absorption, and in certain scope medical stone to average molecular matter in organic compound series
That measures small (simple in construction, diameter is small) has stronger adsorptivity；In addition, in the present invention by using active quaternizing agent and
Chain alkyl reacts to form bi-quaternary ammonium salt.Without changing on the basis of metronidazole structure
Its water-soluble and permeability to sticky sludge can be improved, and after introducing nitrogen heterocyclic ring group in bi-quaternary ammonium salt it can be made slow
Release performance to make moderate progress, so except that can change the water solubility of metronidazole, surface-active and kill
Outside bacterium characteristic, moreover it is possible to make new organic diammonium compound that there is stronger sustained release performance, by being grafted on medical stone, enter one
Step improves the sustained release performance and stability of new organic diammonium compound.
Modified medical stone can not only be to the peculiar smell adsorption in air and removal, and also has efficient bactericidal property,
It has the advantages that chemical stability is good, residual toxicity is low, durable antibacterial effect.
The preparation method of the modified silicon rubber powder comprises the following steps：
(1) poloxamer188 is added into silver nitrate aqueous solution, is stirred, adds trisodium citrate, is stirred
Irradiate under ultraviolet light afterwards, obtain Nano Silver stoste；The mass concentration of the silver nitrate aqueous solution is 0.4mg/mL, the nitric acid
The silver-colored weight ratio with the poloxamer188, the trisodium citrate is 1：0.85：0.9；Ice vinegar is added into Nano Silver stoste
Acid solution (mass fraction of glacial acetic acid is 10% in the glacial acetic acid solution), glycerine, stir, add poloxamer
With silica white, silica white-poloxamer colloidal sol of Nano Silver is obtained, NaHCO is added dropwise3Solution adjusts pH to 6, and standing makes its gel
Change, obtain nano silver antimicrobial gel；The Nano Silver stoste and the glacial acetic acid solution, the glycerine, the poloxamer, institute
The weight ratio for stating silica white is 1：0.06：0.06：1.2：0.02；The NaHCO3The concentration of solution is 1mol/L；
(2) nano silver antimicrobial gel, silica white are added into agitator, 3h is stirred, obtains modified silicon rubber powder, the nanometer
The weight ratio of silver-colored antibacterial gel and the silica white is 1：3.
The granularity of heretofore described silica white is 200-400 mesh；Preferably, the granularity of the silica white is 300 mesh.
Another aspect of the present invention provides a kind of preparation method of sterilized eliminating smell agent, comprises the following steps：
(1) modified silicon rubber powder, neopelex are added by weight into reactor, lauric monoglyceride,
Stir, 1h is stirred after being warming up to 40-50 DEG C, 50 DEG C are dried under reduced pressure 8h；
(2) modified medical stone, deionized water, dodecyl dimethyl benzyl bromine are added in mixture into step (1)
Change ammonium, dried after stirring；
(3) it is 60% tea tree ethereal oil, plant extracts and mass fraction to be added in the particle dried into step (2)
Ethanol water, is stirred well mixed, obtains the sterilized eliminating smell agent.
Containing the Nano Silver and quaternary ammonium salt for being capable of durable antibiotic antivirus composition in the present invention, can have day and night for 365 days
Effect ground suppress various harmful bacterias in in-car and indoor influenza virus, Escherichia coli, staphylococcus aureus and air with
And bacterial spore, prevent its propagation, antibiotic rate is up to more than 99.9%；Using deionized water, natural plant extracts, nanometer
Silver, ethanol etc., malicious chemical analysis is not contained, it is without any side effects to body, without secondary pollution, use safety, ring
Protect；Sterilized eliminating smell agent adhesive force is superpower in the present invention, no matter to clear glass, dark home textile, furniture, wallpaper, coating etc.
Surface can arbitrarily spray, unrestricted.
The present invention is specifically described below by embodiment.It is necessarily pointed out that following examples are only used
In the invention will be further described, it is impossible to be interpreted as limiting the scope of the invention, professional and technical personnel in the field
Some the nonessential modifications and adaptations made according to the content of the invention described above, still fall within protection scope of the present invention.
In addition, if without other explanations, it is raw materials used be all it is commercially available, be purchased from traditional Chinese medicines chemical reagent.
Embodiment 1
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 42
Part, 9 parts of modified silicon rubber powder, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, 46 parts of deionized water,
2 parts of lauric monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes thin
Lotus extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is grafted for nano medical stone
Bi-quaternary ammonium salt, the modified silicon rubber powder are the silica white loading nano silvery, and the ethanol is the ethanol that mass fraction is 60%
The aqueous solution；Mint extract described in the plant extracts and the pot marigold extract, the orange peel extract, the gold
The weight ratio of honeysuckle flower extract is 1：0.8：4：3；Bi-quaternary ammonium salt described in the modified medical stone is containing the double quaternary ammoniums of imidazolyl heterocycle
Salt, the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle include metronidazole, epoxychloropropane,
Long-chain alkyl tertiary amine；The long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl methyl tertiary amine, the length
The weight ratio of dodecyldimethylamine base tertiary amine described in alkyl group tertiary amine and the dodecylbenzyl methyl tertiary amine is 1：0.24；
The preparation method of the sterilized eliminating smell agent, comprises the following steps：
(1) modified silicon rubber powder, neopelex are added by weight into reactor, lauric monoglyceride,
Stir, 1h is stirred after being warming up to 45 DEG C, 50 DEG C are dried under reduced pressure 8h；
(2) modified medical stone, deionized water, dodecyl dimethyl benzyl bromine are added in mixture into step (1)
Change ammonium, dried after stirring；
(3) it is 60% tea tree ethereal oil, plant extracts and mass fraction to be added in the particle dried into step (2)
Ethanol water, is stirred well mixed, obtains the sterilized eliminating smell agent.
The preparation method of the modified medical stone comprises the following steps：
Nano medical stone, acetone are added into reactor, after stirring, adds 2mol/L sodium hydrate aqueous solution,
Stir, alkalize 3h at a temperature of 50 DEG C, and the bi-quaternary ammonium salt containing imidazolyl heterocycle of synthesis is then added portionwise, is reacted under the conditions of 60 DEG C
10h, after reaction terminates, room temperature is cooled to, filters, filter cake is washed with deionized 3 times, again with methanol elution, 40 DEG C of decompressions
12h is dried, obtains the modified medical stone；The nano medical stone and the acetone, the 2mol/L sodium hydrate aqueous solution,
The weight ratio of the bi-quaternary ammonium salt containing imidazolyl heterocycle is 1：5：4：0.4.
The preparation method of the bi-quaternary ammonium salt containing imidazolyl heterocycle comprises the following steps：
Epoxychloropropane is added to reactor, 75 DEG C is warming up to, dodecyldimethylamine in long-chain alkyl tertiary amine is slowly added dropwise
Base tertiary amine, after being added dropwise, 0.5h is stirred, then dodecylbenzyl methyl tertiary amine is slowly added dropwise, stirred 0.5h, be cooled to 55
DEG C, acetonitrile is added, then divides 3 addition metronidazoles, insulation reaction 8h, is cooled to room temperature, subtracts
Pressure concentration, obtains the crude product of bi-quaternary ammonium salt containing imidazolyl heterocycle, adds acetone stirring 0.5h, is concentrated under reduced pressure, and obtains containing the double quaternary ammoniums of imidazolyl heterocycle
Salt；The mol ratio of the epoxychloropropane and the long-chain alkyl tertiary amine, the metronidazole is
1：0.56：0.6；The weight ratio of the epoxychloropropane and the acetonitrile, the acetone is 1：6：4.
The preparation method of the modified silicon rubber powder comprises the following steps：
(1) poloxamer188 is added into silver nitrate aqueous solution, is stirred, adds trisodium citrate, is stirred
Irradiate under ultraviolet light afterwards, obtain Nano Silver stoste；The mass concentration of the silver nitrate aqueous solution is 0.4mg/mL, the nitre
The silver-colored weight ratio with the poloxamer188, the trisodium citrate of acid is 1：0.85： 0.9；Added into Nano Silver stoste
Glacial acetic acid solution (mass fraction of glacial acetic acid is 10% in the glacial acetic acid solution), glycerine, stir, add pool Lip river
Husky nurse and silica white, silica white-poloxamer colloidal sol of Nano Silver is obtained, NaHCO is added dropwise3Solution adjusts pH to 6, and standing makes it
Gelation, obtain nano silver antimicrobial gel；The Nano Silver stoste and the glacial acetic acid solution, the glycerine, the pool Lip river are husky
Nurse, the weight ratio of the silica white are 1：0.06：0.06：1.2：0.02；The NaHCO3The concentration of solution is 1mol/L；
(2) nano silver antimicrobial gel, silica white are added into agitator, 3h is stirred, obtains modified silicon rubber powder, the nanometer
The weight ratio of silver-colored antibacterial gel and the silica white is 1：3；The granularity of the silica white is 300 mesh.
Embodiment 2
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 30
Part, 13 parts of modified silicon rubber powder, 15 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, deionized water 49
Part, 2 parts of lauric monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts bag
Include mint extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is nano medical stone
Bi-quaternary ammonium salt is grafted, the modified silicon rubber powder is the silica white loading nano silvery, and the ethanol is that mass fraction is 60%
Ethanol water；Mint extract described in the plant extracts and the pot marigold extract, the orange peel extract, institute
The weight ratio for stating Honegsukle flower P.E is 1：0.8：4：3；Bi-quaternary ammonium salt described in the modified medical stone is double containing imidazolyl heterocycle
Quaternary ammonium salt, the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle include metronidazole, epoxy chloropropionate
Alkane, long-chain alkyl tertiary amine；The long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl methyl tertiary amine, described
The weight ratio of the tertiary amine of dodecyldimethylamine base described in long-chain alkyl tertiary amine and the dodecylbenzyl methyl tertiary amine is 1：0.24；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified medical stone, described contain imidazolyl heterocycle
The preparation method of bi-quaternary ammonium salt, the preparation method of the modified silicon rubber powder are the same as embodiment 1.
Embodiment 3
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 50
Part, 5 parts of modified silicon rubber powder, 6 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, 46 parts of deionized water,
2 parts of lauric monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes thin
Lotus extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is grafted for nano medical stone
Bi-quaternary ammonium salt, the modified silicon rubber powder are the silica white loading nano silvery, and the ethanol is the ethanol that mass fraction is 60%
The aqueous solution；Mint extract described in the plant extracts and the pot marigold extract, the orange peel extract, the gold
The weight ratio of honeysuckle flower extract is 1：0.8：4：3；Bi-quaternary ammonium salt described in the modified medical stone is containing the double quaternary ammoniums of imidazolyl heterocycle
Salt, the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle include metronidazole, epoxychloropropane,
Long-chain alkyl tertiary amine；The long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl methyl tertiary amine, the length
The weight ratio of dodecyldimethylamine base tertiary amine described in alkyl group tertiary amine and the dodecylbenzyl methyl tertiary amine is 1：0.24；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified medical stone, described contain imidazolyl heterocycle
The preparation method of bi-quaternary ammonium salt, the preparation method of the modified silicon rubber powder are the same as embodiment 1.
Embodiment 4
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 42
Part, 9 parts of modified silicon rubber powder, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, 46 parts of deionized water,
2 parts of lauric monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes thin
Lotus extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is grafted for nano medical stone
Bi-quaternary ammonium salt, the modified silicon rubber powder are the silica white loading nano silvery, and the ethanol is the ethanol that mass fraction is 60%
The aqueous solution；Mint extract described in the plant extracts and the pot marigold extract, the orange peel extract, the gold
The weight ratio of honeysuckle flower extract is 1：0.8：4：3；Bi-quaternary ammonium salt described in the modified medical stone is containing the double quaternary ammoniums of imidazolyl heterocycle
Salt, the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle include metronidazole, epoxychloropropane,
Long-chain alkyl tertiary amine；The long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl methyl tertiary amine, the length
The weight ratio of dodecyldimethylamine base tertiary amine described in alkyl group tertiary amine and the dodecylbenzyl methyl tertiary amine is 1：0.1；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified medical stone, described contain imidazolyl heterocycle
The preparation method of bi-quaternary ammonium salt, the preparation method of the modified silicon rubber powder are the same as embodiment 1.
Embodiment 5
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 42
Part, 9 parts of modified silicon rubber powder, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, 46 parts of deionized water,
2 parts of lauric monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes thin
Lotus extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is grafted for nano medical stone
Bi-quaternary ammonium salt, the modified silicon rubber powder are the silica white loading nano silvery, and the ethanol is the ethanol that mass fraction is 60%
The aqueous solution；Mint extract described in the plant extracts and the pot marigold extract, the orange peel extract, the gold
The weight ratio of honeysuckle flower extract is 1：0.8：4：3；Bi-quaternary ammonium salt described in the modified medical stone is containing the double quaternary ammoniums of imidazolyl heterocycle
Salt, the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle include metronidazole, epoxychloropropane,
Long-chain alkyl tertiary amine；The long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl methyl tertiary amine, the length
The weight ratio of dodecyldimethylamine base tertiary amine described in alkyl group tertiary amine and the dodecylbenzyl methyl tertiary amine is 1：0.6；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified medical stone, described contain imidazolyl heterocycle
The preparation method of bi-quaternary ammonium salt, the preparation method of the modified silicon rubber powder are the same as embodiment 1.
Embodiment 6
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 42
Part, 9 parts of modified silicon rubber powder, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, 46 parts of deionized water,
2 parts of lauric monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes thin
Lotus extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is grafted for nano medical stone
Bi-quaternary ammonium salt, the modified silicon rubber powder are the silica white loading nano silvery, and the ethanol is the ethanol that mass fraction is 60%
The aqueous solution；Mint extract described in the plant extracts and the pot marigold extract, the orange peel extract, the gold
The weight ratio of honeysuckle flower extract is 1：0.8：6：5；Bi-quaternary ammonium salt described in the modified medical stone is containing the double quaternary ammoniums of imidazolyl heterocycle
Salt, the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle include metronidazole, epoxychloropropane,
Long-chain alkyl tertiary amine；The long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl methyl tertiary amine, the length
The weight ratio of dodecyldimethylamine base tertiary amine described in alkyl group tertiary amine and the dodecylbenzyl methyl tertiary amine is 1：0.24；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified medical stone, described contain imidazolyl heterocycle
The preparation method of bi-quaternary ammonium salt, the preparation method of the modified silicon rubber powder are the same as embodiment 1.
Embodiment 7
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 42
Part, 9 parts of modified silicon rubber powder, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, 46 parts of deionized water,
2 parts of lauric monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes thin
Lotus extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is grafted for nano medical stone
Bi-quaternary ammonium salt, the modified silicon rubber powder are the silica white loading nano silvery, and the ethanol is the ethanol that mass fraction is 60%
The aqueous solution；Mint extract described in the plant extracts and the pot marigold extract, the orange peel extract, the gold
The weight ratio of honeysuckle flower extract is 1：1：1：2；Bi-quaternary ammonium salt described in the modified medical stone is bi-quaternary ammonium salt containing imidazolyl heterocycle,
The preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle includes metronidazole, epoxychloropropane, length
Alkyl group tertiary amine；The long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl methyl tertiary amine, the long-chain
The weight ratio of the tertiary amine of dodecyldimethylamine base described in alkyl tertiary amine and the dodecylbenzyl methyl tertiary amine is 1：0.24；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified medical stone, described contain imidazolyl heterocycle
The preparation method of bi-quaternary ammonium salt, the preparation method of the modified silicon rubber powder are the same as embodiment 1.
Comparative example 1
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 50
Part, 9 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, 46 parts of deionized water, lauric monoglyceride
2 parts, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes mint extract, golden small cup
Flower extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is that nano medical stone is grafted bi-quaternary ammonium salt, described
Ethanol is the ethanol water that mass fraction is 60%；Mint extract described in the plant extracts carries with the pot marigold
It is 1 to take thing, the orange peel extract, the weight ratio of the Honegsukle flower P.E：0.8：4：3；Described in the modified medical stone
Bi-quaternary ammonium salt is bi-quaternary ammonium salt containing imidazolyl heterocycle, and the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle includes 1- ethoxys -2-
5-nitro imidazole, epoxychloropropane, long-chain alkyl tertiary amine；The long-chain alkyl tertiary amine be dodecyldimethylamine base tertiary amine,
Dodecylbenzyl methyl tertiary amine, dodecyldimethylamine base tertiary amine described in the long-chain alkyl tertiary amine and the dodecyl benzyl
The weight ratio of ylmethyl tertiary amine is 1：0.24；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified medical stone, described contain imidazolyl heterocycle
The preparation method of bi-quaternary ammonium salt is the sterilized eliminating smell agent noon modified silicon rubber powder with embodiment 1, difference.
Comparative example 2
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 48
Part, 13 parts of modified silicon rubber powder, 1 part of neopelex, 1 part of tea tree ethereal oil, 46 parts of deionized water, lauric monoglyceride
2 parts of ester, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes mint extract, gold
Small cup flower extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is that nano medical stone is grafted bi-quaternary ammonium salt, institute
It is the silica white loading nano silvery to state modified silicon rubber powder, and the ethanol is the ethanol water that mass fraction is 60%；It is described
Mint extract described in plant extracts and the pot marigold extract, the orange peel extract, the Honegsukle flower P.E
Weight ratio be 1： 0.8：4：3；Bi-quaternary ammonium salt described in the modified medical stone is bi-quaternary ammonium salt containing imidazolyl heterocycle, described to contain
The preparing raw material of imidazolyl heterocycle bi-quaternary ammonium salt includes metronidazole, epoxychloropropane, chain alkyl
Tertiary amine；The long-chain alkyl tertiary amine is dodecyldimethylamine base tertiary amine, dodecylbenzyl methyl tertiary amine, the chain alkyl uncle
The weight ratio of the tertiary amine of dodecyldimethylamine base described in amine and the dodecylbenzyl methyl tertiary amine is 1：0.24；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified medical stone, described contain imidazolyl heterocycle
The preparation method of bi-quaternary ammonium salt, the preparation method of the modified silicon rubber powder are the sterilized taste removal with embodiment 1, difference
Without plant extracts in agent.
Comparative example 3
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Nano medical stone 42
Part, 9 parts of modified silicon rubber powder, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, 46 parts of deionized water,
2 parts of lauric monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes thin
Lotus extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The ethanol is the ethanol that mass fraction is 60%
The aqueous solution；Mint extract described in the plant extracts and the pot marigold extract, the orange peel extract, the gold
The weight ratio of honeysuckle flower extract is 1：0.8：4：3；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified silicon rubber powder are distinguished with embodiment 1
Modified medical stone is replaced in the nano medical stone.
Comparative example 4
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Modified medical stone 42
Part, 9 parts of silica white, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, deionized water 46 part, month
2 parts of cinnamic acid monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes peppermint
Extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The modified medical stone is that nano medical stone grafting is double
Quaternary ammonium salt, the ethanol are the ethanol water that mass fraction is 60%；Mint extract described in the plant extracts with
The pot marigold extract, the orange peel extract, the weight ratio of the Honegsukle flower P.E are 1：0.8：4：3；The modification
Bi-quaternary ammonium salt described in medical stone is bi-quaternary ammonium salt containing imidazolyl heterocycle, and the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle includes
Metronidazole, epoxychloropropane, long-chain alkyl tertiary amine；The long-chain alkyl tertiary amine is myristyl
Dimethyl tertiary amine, dodecylbenzyl methyl tertiary amine, dodecyldimethylamine base tertiary amine described in the long-chain alkyl tertiary amine and institute
The weight ratio for stating dodecylbenzyl methyl tertiary amine is 1：0.24；
The preparation method of the sterilized eliminating smell agent, the preparation method of the modified medical stone, described contain imidazolyl heterocycle
The preparation method of bi-quaternary ammonium salt is that the silica white replaces modified silicon rubber powder with embodiment 1, difference.
Comparative example 5
The sterilized eliminating smell agent, is calculated by weight, and the sterilized eliminating smell agent includes：Nano medical stone 42
Part, 9 parts of silica white, 10 parts of plant extracts, 1 part of neopelex, 1 part of tea tree ethereal oil, deionized water 46 part, month
2 parts of cinnamic acid monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, 50 parts of ethanol；The plant extracts includes peppermint
Extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；The ethanol is the ethanol water that mass fraction is 60%
Solution；Mint extract described in the plant extracts and the pot marigold extract, the orange peel extract, the gold and silver
The weight ratio of flower extract is 1：0.8：4：3；
For the preparation method of the sterilized eliminating smell agent with embodiment 1, difference is that the nano medical stone replaces being modified
Medical stone, the silica white replace modified silicon rubber powder.
Performance test：
1st, stability：Sterilized eliminating smell agent 5g is taken respectively, is placed in 10mL centrifuge tubes, is centrifuged with 4000r/min
30min, sterilized eliminating smell agent outward appearance and stretchability situation of change after centrifugation；
Stability is good：Sterilized eliminating smell agent outward appearance and stretchability have no significant change after centrifugation；
Stability is general：For sterilized eliminating smell agent outward appearance without significant change, stretchability is general, can easily apply after centrifugation
It is put on gauze, but adhesiveness dies down；
Stability is poor：Sterilized eliminating smell agent outward appearance has significant change (layering) after centrifugation, and stretchability is deteriorated, it is impossible to side
Being applied on gauze just, adhesiveness dies down.
2nd, high temperature resistant：Placed 90 days under the conditions of the sealing of sterilized eliminating smell agent is better than into 50 DEG C, observe sterilized taste removal
Agent outward appearance and stretchability situation of change；
It is good：Sterilized eliminating smell agent outward appearance and stretchability have no significant change；
Typically：Outward appearance has significant change, and stretchability is deteriorated, it is impossible to is easily applied on gauze, adhesiveness dies down；
Difference：Outward appearance has significant change (layering), and stretchability is deteriorated, it is impossible to is easily applied on gauze, adhesiveness dies down.
3rd, biocidal property
For trying bacterium：Coccobacillus, which is read, using staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa and white carries out biocidal property examination
Test, be purchased from Chinese industrial Microbiological Culture Collection administrative center, CICC.
Sterilizing function is according to national standard GB21551.2-2010《The antibacterial of family expenses and similar applications electrical equipment, degerming, purification function
The particular/special requirement of anti-biotic material》Middle absorption process detects material bacteria resistance energy.
4th, taste removal
Function of odor removal is according to national standard GB21551.4-2010《The antibacterial of family expenses and similar applications electrical equipment, degerming, purification function
The particular/special requirement of refrigerator》Tested.
The performance test results of table 1
It is seen from the above data that sterilized eliminating smell agent provided by the invention its can kill Staphylococcus aureus, big
Enterobacteria, pseudomonas aeruginosa, shigella dysenteriae and white read the various bacterias such as coccobacillus, and adsorption capacity and sterilization capability are excellent, tool
There are the sterilization sterilizing of high intensity, anti-corrosion, fresh-keeping and function of odor removal.
Foregoing example is merely illustrative, some features of the feature for explaining the disclosure.Appended claim
It is intended to require the scope as wide as possible being contemplated that, and embodiments as presented herein is only according to all possible embodiment
Combination selection embodiment explanation.Therefore, the purpose of applicant is appended claim not by the explanation present invention
Feature example selectional restriction.And the progress in science and technology will not formed due to the inaccuracy of language performance and not
The possible equivalent or son being presently considered are replaced, and these changes should also be interpreted by appended in the conceived case
Claim covers.
Claims (10)
1. a kind of sterilized eliminating smell agent, it is characterised in that calculate by weight, the sterilized eliminating smell agent includes：It is modified
Medical stone 30-50 parts, modified silicon rubber powder 5-13 parts, plant extracts 2-15 parts, neopelex 0.5-3 parts, tea tree
Essential oil 0.5-2 parts, deionized water 30-60 parts, lauric monoglyceride 0.1-5 parts, dodecyl dimethyl benzyl ammonium bromide
0.5-2 parts, ethanol 30-55 parts；
Wherein, the plant extracts includes mint extract, pot marigold extract, orange peel extract, Honegsukle flower P.E；Institute
State modified medical stone and be grafted bi-quaternary ammonium salt for nano medical stone, the modified silicon rubber powder is the silica white loading nano silvery, institute
It is the ethanol water that mass fraction is 60% to state ethanol.
2. sterilized eliminating smell agent according to claim 1, it is characterised in that calculate by weight, it is described sterilized to remove
Taste agent includes：Modified medical stone 35-45 parts, modified silicon rubber powder 8-12 parts, plant extracts 2-10 parts, neopelex
0.5-2 parts, tea tree ethereal oil 0.5-2 parts, deionized water 40-50 parts, lauric monoglyceride 1-5 parts, dodecyl dimethyl benzene
Methyl bromide ammonium 0.5-2 parts, ethanol 40-55 parts.
3. sterilized eliminating smell agent according to claim 2, it is characterised in that calculate by weight, it is described sterilized to remove
Taste agent includes：Modified 42 parts of medical stone, 9 parts of modified silicon rubber powder, 10 parts of plant extracts, 1 part of neopelex, tea tree
1 part of essential oil, 46 parts of deionized water, 2 parts of lauric monoglyceride, 1 part of dodecyl dimethyl benzyl ammonium bromide, ethanol 50
Part.
4. sterilized eliminating smell agent according to claim 1, it is characterised in that peppermint described in the plant extracts is extracted
The weight ratio of thing and the pot marigold extract, the orange peel extract, the Honegsukle flower P.E is 1：(0.5-1)：(1-
6)：(2-5).
5. sterilized eliminating smell agent according to claim 4, it is characterised in that peppermint described in the plant extracts is extracted
The weight ratio of thing and the pot marigold extract, the orange peel extract, the Honegsukle flower P.E is 1：0.8：4：3.
6. sterilized eliminating smell agent according to claim 1, it is characterised in that bi-quaternary ammonium salt described in the modified medical stone
For bi-quaternary ammonium salt containing imidazolyl heterocycle, the preparing raw material of the bi-quaternary ammonium salt containing imidazolyl heterocycle includes 1- ethoxy -2- methyl -5- nitre
Base imidazoles, epoxychloropropane, long-chain alkyl tertiary amine.
7. sterilized eliminating smell agent according to claim 6, it is characterised in that the long-chain alkyl tertiary amine includes dodecyl
One kind in dimethyl tertiary amine, dodecyldimethylamine base tertiary amine, hexadecyldimethyl benzyl ammonium tertiary amine, dodecylbenzyl methyl tertiary amine
It is or a variety of.
8. sterilized eliminating smell agent according to claim 7, it is characterised in that the long-chain alkyl tertiary amine is myristyl two
Methyl tertiary amine, dodecylbenzyl methyl tertiary amine.
9. sterilized eliminating smell agent according to claim 8, it is characterised in that the tetradecane described in the long-chain alkyl tertiary amine
The weight ratio of base dimethyl tertiary amine and the dodecylbenzyl methyl tertiary amine is 1：(0.1-0.6).
10. according to the preparation method of any one of the claim 1-9 sterilized eliminating smell agents, it is characterised in that including following
Step：
(1) modified silicon rubber powder, neopelex, lauric monoglyceride, stirring are added by weight into reactor
Uniformly, 1h is stirred after being warming up to 40-50 DEG C, 50 DEG C are dried under reduced pressure 8h；
(2) modified medical stone, deionized water, dodecyl dimethyl benzyl ammonium bromide are added in mixture into step (1),
Dried after stirring；
(3) ethanol water that tea tree ethereal oil, plant extracts and mass fraction are 60% is added in the particle dried into step (2)
Solution, is stirred well mixed, obtains the sterilized eliminating smell agent.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420342A (en) * | 2019-06-21 | 2019-11-08 | 苟小平 | A kind of deodorant for refrigerator |
| CN114287451A (en) * | 2021-12-31 | 2022-04-08 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of natural plant modified antibacterial liquid and product thereof |
| CN116159172A (en) * | 2023-04-20 | 2023-05-26 | 北京安吉贝玛健康科技有限公司 | Efficient deodorant and preparation method thereof |
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| CN105776459A (en) * | 2016-05-11 | 2016-07-20 | 上海立昌环境工程股份有限公司 | Environment-friendly flocculating agent applicable to painting workshop circulation water treatment, and preparation method and application thereof |
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| CN1168765A (en) * | 1996-06-17 | 1997-12-31 | 安永 | Strong deodorizing and sterilizing agent |
| CN1623897A (en) * | 2004-11-19 | 2005-06-08 | 中国乐凯胶片集团公司 | Process for preparing silicon dioxide of carrying nano silver |
| CN101263826A (en) * | 2007-03-14 | 2008-09-17 | 范翔 | Silver ion antimicrobial agent and dry method production process |
| CN102847509A (en) * | 2012-04-17 | 2013-01-02 | 东北农业大学 | Adsorbent for mycotoxin in feed and preparation method thereof |
| CN105776459A (en) * | 2016-05-11 | 2016-07-20 | 上海立昌环境工程股份有限公司 | Environment-friendly flocculating agent applicable to painting workshop circulation water treatment, and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110420342A (en) * | 2019-06-21 | 2019-11-08 | 苟小平 | A kind of deodorant for refrigerator |
| CN114287451A (en) * | 2021-12-31 | 2022-04-08 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of natural plant modified antibacterial liquid and product thereof |
| CN114287451B (en) * | 2021-12-31 | 2022-12-27 | 上海纳米技术及应用国家工程研究中心有限公司 | Preparation method of natural plant modified antibacterial liquid and product thereof |
| CN116159172A (en) * | 2023-04-20 | 2023-05-26 | 北京安吉贝玛健康科技有限公司 | Efficient deodorant and preparation method thereof |
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| CN107646885B (en) | 2020-05-22 |
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Effective date of registration: 20210615 Address after: One of the 1st floor of workshop 1 of Zhaoqing health family Industrial Co., Ltd., Shali Industrial Park, Zhaoqing hi tech Zone, Guangdong Province Patentee after: Qingdajie Biotechnology Co.,Ltd. Address before: 154000 No.48, group 19, beitiexi community, Xiangyang District, Jiamusi City, Heilongjiang Province Patentee before: Wu Yang Patentee before: Xing Yucheng Patentee before: Wang Zhenzhou |
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Denomination of invention: An efficient sterilization and deodorant and its preparation method Effective date of registration: 20231107 Granted publication date: 20200522 Pledgee: Hi tech Zone Technology sub branch of Guangdong Sihui Rural Commercial Bank Co.,Ltd. Pledgor: Qingdajie Biotechnology Co.,Ltd. Registration number: Y2023980064487 |