CN107638479A - A kind of Chinese medicine composition for treating constipation and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating constipation and preparation method thereof Download PDFInfo
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Abstract
The invention provides the Chinese medicine composition for the treatment of constipation, by weight, including following raw material：1~8 part of RADIX POLYGONI MULTIFLORI PREPARATA, 1~8 part of mulberries, 1~8 portion of Semen sesami nigrum, 1~4 part of dried orange peel, 0.5~8 portion of folium sennae, 1~4 part of black tea, 1~6 part of moleplant seed and 0.5~3 part of lepidium seed.In Chinese medicine composition of the present invention：RADIX POLYGONI MULTIFLORI PREPARATA, mulberries and Semen sesami nigrum are monarch drug in a prescription, and dried orange peel is ministerial drug, and folium sennae, moleplant seed and lepidium seed are adjutant, and black tea is to make medicine.Such compatibility, brings out the best in each other.Chinese medicine composition provided by the invention is for the Chinese medicine compound prescription of conventional therapy constipation, and the effect of tonifying the liver and kidney is stronger, and functions of loosening bowel relieving constipation also becomes apparent from, while simultaneous help digestion removes the effect of product.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating constipation and preparation method thereof.
Background technology
Constipation refers to that times of defecation is reduced and (or) excrement is dried and is difficult to resolve, and without defecation, prompts to exist within general more than two days
Constipation.Epidemiological study shows that constipation is clinical common gastrointestinal distress.With the astogeny of population, senile habituation
The patient of constipation is also increasing, and most of Post operations, and postpartum patient due to hematozemia of feeling frustrated it is also more with constipation.
Further, since modern life food is increasingly finer, life stress is increasing, environmental pollution is increasingly heavier, chemicals is got over
Come more so that constipation incidence more and more higher.
Clinically the medicine of widely used treatment constipation mainly has three classes at present：The first kind is to stimulate enterocinesia
It is mostly synthetic for the irritant laxative of main pharmacodynamics, side effect is more, such as clinical practice more " phenolphthalein tablet ",
Sometimes allergic reaction can occur, produce enteritis, dermatitis and hemorrhagic tendency, and it is irritant to kidney, it is also easy to produce dependence and holds
Easily induce or aggravate constipation.Second class is to stimulate intestinal wall to cause defecation reflex and the permeability of partial lubrication effect to be rushed down with hypertonic pressure
Medicine, such as " enema ", it is only capable of alleviating clinical symptoms, and injected by anus, and use is extremely inconvenient, easily formed to medicine according to
Lai Xing.3rd class is traditional compound Chinese medicinal preparation, though being comparatively ideal Chinese patent drug, formulation is mostly cream, pellet, ball, scattered, drink
With, storage inconvenience, such as " Maren wan " be grown up each oral dose be 6~9g, and amount greatly, is swallowed also more difficult.
For the treatment of constipation, traditional Chinese medicine traditional remedies for " with let out control it is secret ", such as《The Treatise on Fevrile Diseases》The treatment emplastic of record
Thing Maziren Wan is exactly typical purgative drugs prescriptions, there is ease constipation to expel the heat-evil, the work(of promoting the circulation of qi defaecation.Although purgatives medicine has good to constipation
Therapeutic action, but qi and blood can also be lost.
The content of the invention
In view of this, it is an object of the invention to provide a kind of Chinese medicine composition for treating constipation, in effectively treatment constipation
While being capable of conditioning engine body insufficiency of vital energy and blood.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The invention provides a kind of Chinese medicine composition for treating constipation, by weight, by the raw material including following components
It is made through water extraction：1~8 part of RADIX POLYGONI MULTIFLORI PREPARATA, 1~8 part of mulberries, 1~8 portion of Semen sesami nigrum, 1~4 part of dried orange peel, 0.5~8 portion of folium sennae, 1~
4 parts of black tea, 1~6 part of moleplant seed and 0.5~3 part of lepidium seed.
Preferably, the raw material includes 3~4 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 2~3 parts of mulberries, 2~4 portions of Semen sesami nigrums, 2~3 parts of dried orange peels, 1
~2 portions of folium sennaes, 2~3 parts of black tea, 2~3 parts of moleplant seeds and 1~2 part of lepidium seed.
Preferably, by weight, the raw material also includes one or both of 2~7 saline cistanches and 1~6 part of cynomorium songaricum.
Preferably, the raw material includes 3~4 portions of saline cistanches and 2~3 parts of cynomorium songaricums.
Preferably, the formulation of the Chinese medicine composition is tablet, granule, capsule, effervescent agent or tea bag.
The present invention provides a kind of preparation method of Chinese medicine composition described in above-mentioned technical proposal, comprises the following steps：
(1) proportionally raw material is mixed, heating extraction after being soaked with water, filtered, obtain extracting solution；
(2) the extraction solution that the step (1) obtains is concentrated, crushed after being dried, obtains Chinese medicine composition.
Preferably, the step of extracting solution is prepared in the step (1) is：By mixed raw material with water immersion 15~
45min, after immersion at 90~100 DEG C 0.5~2h of heating extraction, by after heating gained mixed liquor filter, obtain supernatant and
Precipitation；The precipitation is repeated into above-mentioned immersion, heating extraction and filter operation, merges filtering gained supernatant every time, i.e.,
Solution must be extracted.
Preferably, step (2) the concentration extraction solution to the relative density of 60 DEG C of heat determinations is 1.0~1.2.
Preferably, dried in the step (2) and be for vacuum drying, the vacuum drying condition：45~65 DEG C, vacuum
Spend -0.09~-0.04MPa.
Preferably, the dry granulation that will be obtained after crushing is also included after being crushed in the step (2).
Compared with prior art, the present invention has advantages below to the present invention：
The invention provides a kind of Chinese medicine composition for treating constipation, by weight, including following raw material：1~8 part of system
The tuber of multiflower knotweed, 1~8 part of mulberries, 1~8 portion of Semen sesami nigrum, 1~4 part of dried orange peel, 0.5~8 portion of folium sennae, 1~4 part of black tea, 1~6 part of a thousand pieces of gold
Son and 0.5~3 part of lepidium seed.In Chinese medicine composition of the present invention：RADIX POLYGONI MULTIFLORI PREPARATA, mulberries and Semen sesami nigrum are monarch drug in a prescription, and system is first
Black Return liver, kidney two warp, it is longer than filling liver kidney benefiting essence-blood, and vital essence can be restrained, and it is not cold, not dry, oiliness；Mulberry fruit, Semen sesami nigrum have taste
The work(that the moon is enriched blood, and can ease constipation are promoted the production of body fluid.Dried orange peel is ministerial drug, dried orange peel can invigorating the spleen promoting the circulation of qi, pungent scattered bitter drop, can rush down can be dry, has with mending
Medicine is then mended, and the characteristics of then being rushed down with cathartic, can promote help and the functions of loosening bowel relieving constipation of monarch drug in a prescription.Folium sennae, moleplant seed and Roripa montana
Son is adjutant, and its bitter of folium sennae is cold in nature, matter stick-slip profit, can enter large intestine, rushes down accumulated heat, logical stool, it is few with and can it is aid digestion, remove product
It is stagnant；The pungent scattered bitter drop of moleplant seed, lepidium seed, enters bladder, large intestine channel, and the sharp intestine and small intestine of energy is lower to dislike stagnant thing；Bitter cold medicine is used as assistant
Medicine, improves that unlikely while the functions of loosening bowel relieving constipation of composition a presumptuous guest usurps the role of the host.Black tea is makes medicine, black tea category full fermentation tea, can be with
Help gastro-intestinal digestion, promote appetite, can diuresis, eliminate oedema, have the feature of fragrant and sweet taste alcohol, flavour of a drug, coordinating the drug actions of a prescription can be neutralized.This
The monarch drug in a prescription used is invented based on help, is aided with the medicine of other enhancing help effects and effect of relaxing bowel, such compatibility, phase
Benefit evident.Chinese medicine composition provided by the invention is for the Chinese medicine compound prescription of conventional therapy constipation, and the effect of tonifying the liver and kidney is more
By force, functions of loosening bowel relieving constipation also becomes apparent from, while simultaneous help digestion removes the effect of product.
Chinese medicine composition provided by the invention by reasonable compatibility, substantially abolished " with let out control it is secret " traditional remedies,
Conditioning energy and blood of human body deficiency, moisturize laxation are focused on, and there is the characteristics of " benefit does not love evil, evil do not hinder just ".It is mainly used in treating year
It is old it is weak, after being ill, postpartum, postoperative, children's body fluid deficiency blood is few etc., and constipation, effective percentage can reach 97.5%.
In certain specific embodiments of the invention, further addition saline cistanche and/or cynomorium songaricum are adjutant to the present invention, are risen
To the effect of enhancing monarch drug in a prescription help effect and moisturize laxation.
Present invention also offers a kind of preparation method of the Chinese medicine composition of the treatment constipation, by the original of Chinese medicine composition
Active principle is extracted in material.Traditional Chinese medicine decoction can either be kept to absorb the characteristics of fast, rapid-action, additionally it is possible to retain more
Volatile ingredient.
In certain specific embodiments of the invention, after the present invention pelletizes the active ingredient obtained after extraction, relatively
In the Chinese medicine composition do not pelletized, its dissolution rate and dissolution rate improve more than 20%.
In some specific embodiments, tea bag is made in the Chinese medicine composition of the treatment constipation by the present invention, is carried
It is convenient, it is gas micro-perfume after brewing, sweet sweet tea, in good taste, there are the enjoyment having tea, the effect cured the disease.
Embodiment
The invention provides a kind of Chinese medicine composition for treating constipation, by weight, including following raw material：1~8 part of system
The tuber of multiflower knotweed, 1~8 part of mulberries, 1~8 portion of Semen sesami nigrum, 1~4 part of dried orange peel, 0.5~8 portion of folium sennae, 1~4 part of black tea, 1~6 part of a thousand pieces of gold
Son and 0.5~3 part of lepidium seed.Preferably, the raw material includes 3~4 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 2~3 parts of mulberries, 2~4 parts of Semen sesami nigrums, 2
~3 parts of dried orange peels, 1~2 portion of folium sennae, 2~3 parts of black tea, 2~3 parts of moleplant seeds and 1~2 part of lepidium seed.
In the present invention, the raw material of the Chinese medicine composition preferably also includes saline cistanche and cynomorium songaricum.It is furthermore preferred that also include
One or both of 2~7 saline cistanches and 1~6 part of cynomorium songaricum；One kind most preferably in 3~4 portions of saline cistanches and 2~3 parts of cynomorium songaricums
Or two kinds.
RADIX POLYGONI MULTIFLORI PREPARATA：For the Preparation process product of the fleece-flower root, Radix Polygoni Multiflori forms with black soya bean with drying after boiling, its preparation method reference《In
State's pharmacopeia》Under prepared fleece flower root item.RADIX POLYGONI MULTIFLORI PREPARATA Return liver, the heart, kidney channel, the effect of help essence and blood is better than Radix Polygoni Multiflori, and Radix Polygoni Multiflori is heavier
In relaxing bowel.The present invention uses RADIX POLYGONI MULTIFLORI PREPARATA as monarch drug in a prescription, based on help energy and blood of human body, abolishes " being controlled to let out for traditional remedies
It is secret ".
Mulberries：It is sweet cold in nature, enter lung, liver, kidney, large intestine channel, have tonify the liver and kidney, promote the production of body fluid ease constipation the effect of.The present invention adopts
Be monarch drug in a prescription with mulberries, take its can the work(that relaxes bowel of nourishing yin and supplementing blood and can, based on recuperating qi-blood deficiency, moisturize laxation is
It is auxiliary.In the present invention, the mulberries are preferably black mulberries.
Semen sesami nigrum：It is sweet mild-natured, return lung, spleen, liver and kidney channel.The present invention using Semen sesami nigrum as monarch drug in a prescription, play nourishing yin and supplementing blood,
The effect that ease constipation is promoted the production of body fluid, nourishing yin and supplementing blood are relaxed bowel with moisturizing while focusing on help.
Dried orange peel：Bitter, pungent, warm-natured, return lung, the spleen channel, are qi-activating drug.The pungent scattered bitter drop of dried orange peel, hot-tempered it can let out, the present invention is with old
Skin is adjutant, for strengthening benefiting action and moistening dryness for relaxing bowels effect in monarch drug in a prescription.
Folium sennae：It is sweet, bitter, tremble with fear, return large intestine channel.With a small amount of folium sennae in the present invention, energy is aid digestion, except stagnating, and is
Chinese medicine composition, which provides, to help digestion except product effect.
Moleplant seed：Acrid flavour, warm-natured, Return liver, kidney, large intestine channel.Lepidium seed：Acrid flavour, hardship, it is cold in nature, enter lung, bladder, large intestine channel.
Using moleplant seed and lepidium seed as adjutant in Chinese medicine composition of the present invention, can tonneau intestine and small intestine, it is lower to dislike stagnant thing, strengthen ease constipation
Defaecation and help digestion except product effect.
Black tea：For full fermentation tea, can coordinating the drug actions of a prescription, and nurse one's health the taste of Chinese medicine composition, improve the compliance of patient,
It is easy to take.
Saline cistanche：It is sweet, salty, it is warm-natured.Return kidney, large intestine channel.The medicine is to help auxiliary medicine in side, energy principal drug assistance kidney-replenishing,
The power of benefiting essence-blood, and can moisturize laxation.
Cynomorium songaricum：It is sweet, it is warm-natured.Return liver and kidney channel.Also it is adjutant in this prescription, energy principal drug assistance kidney-replenishing, the power of benefiting essence-blood,
And can moisturize laxation.
In the present invention, it is to further enhance monarch drug in a prescription benefiting action, improve simultaneously to add the saline cistanche and cynomorium songaricum
The moisturize laxation effect of prescription.
The present invention does not have special restriction to the raw material sources of Chinese medicine composition described in above-mentioned technical proposal, using commercially available business
Product.
In the present invention, the formulation of the Chinese medicine composition is tablet, granule, capsule, effervescent agent or tea bag.This
Invent the Chinese medicine composition and be prepared as the methods of various formulations and use conventional formulation mode.Chinese medicine group provided by the invention
Compound is convenient for carrying after various preparations are made, good in taste, the taste of the black tea mediation Chinese medicine composition in raw material, has tea perfume
Taste.
Specifically, when Chinese medicine composition formulation of the present invention is tea bag, its is easy to carry, is easy to drink, gas is micro-
Fragrant, sweet sweet tea, there are the enjoyment having tea, the effect cured the disease, avoid that conventional Chinese medicine composition mouthfeel is bad, patient is reluctant what is taken
Problem.
Present invention also offers a kind of preparation method of Chinese medicine composition described in above-mentioned technical proposal, comprise the following steps：
(1) proportionally raw material is mixed, heating extraction after being soaked with water, filtered, obtain extracting solution；
(2) the extraction solution that the step (1) obtains is concentrated, crushed after being dried, obtains Chinese medicine composition.
The currently preferred raw material by the Chinese medicine composition remixes after crushing；The particle diameter that the raw material crushes is preferred
For 20~80 mesh, more preferably 60 mesh.
The present invention mixes the raw material of the Chinese medicine composition in proportion, soaks 15~45min with water, after immersion 90~
0.5~2h of heating extraction at 100 DEG C, gained mixed liquor after heating is filtered, obtains supernatant and precipitation；The precipitation is repeated
Above-mentioned immersion, heating extraction and filter operation are carried out, merges filtering gained supernatant every time, produces extraction solution.
In the present invention, the mass ratio of the raw material or precipitation and each immersion water is 1:6~10, more preferably 1:8.
Soak time of the present invention is preferably 25~35min, more preferably 30min.Heat time of the present invention is preferably 1~
1.5h.The number of the present invention that repeat that precipitates is preferably 1~4 time, more preferably 2 times.The present invention grasps to the filtering
It is not particularly limited, using conventional filtration mode.
Obtain after extracting solution, the present invention is concentrated extraction solution, crushed after being dried, obtains Chinese medicine composition.This
It is preferably to be concentrated under reduced pressure to invent the method for concentration, is more preferably concentrated under reduced pressure at 55~70 DEG C.It is of the present invention to subtract
The pressure of pressure concentration is preferably -0.06~-0.04MPa, more preferably -0.05MPa.The extraction obtained after concentration of the present invention
Solution relative density is 1.0~1.2 (60 DEG C of thermal measurements).
In the present invention, the method for drying the extraction solution after the concentration is preferably low-temperature vacuum drying, more preferably
It is dried in vacuo at 45~65 DEG C, most preferably 60 DEG C.The vacuum of low-temperature vacuum drying of the present invention preferably -0.09~-
0.04MPa, more preferably -0.06~-0.05MPa.In the present invention, the time of the low-temperature vacuum drying is preferably 2~6h,
More preferably 3~4h.
The present invention can reduce loss of the preparation process to extraction of substance using low temperature concentration and low temperature drying, prevent from extracting
Volatile materials in solution is lost in.
In the present invention, the powder particle diameter is preferably 10~50 mesh, more preferably 18~20 mesh.
It is currently preferred after being pulverized to mix the dry powder that crushing obtains with pharmaceutic adjuvant, pelletize, obtain Chinese traditional medicine composition
Thing.The present invention can improve the dissolution rate and dissolution rate of medicine after dry powder is pelletized, be carried relative to the dry powder do not pelletized
It is high by more than 20%.
In the present invention, the mass ratio of the dry powder and pharmaceutic adjuvant is preferably 4~6:1, more preferably 5:1.In this hair
In bright, the pharmaceutic adjuvant includes but is not limited to wetting agent, adhesive, filler etc..
In the present invention, the method for granulating is preferably wet granulation, using the wet granulation mode of routine.
In the present invention, the pharmaceutic adjuvant is preferably the ethanol solution, starch and dextrin of mass fraction 80~95%, its
The gross mass of middle starch and dextrin and the mass ratio of dry powder are 0.4~1.0:0.5~2；More preferably 0.8:1.
In the present invention, the mass ratio of the ethanol solution of the mass fraction 80~95%, starch and dextrin is preferably
0.54~0.9:0.2~0.8:0.2~0.8；Most preferably 0.45~0.9:0.3~0.4:0.3~0.4.
Chinese medicine composition of the present invention uses conventional formulation mode when being prepared as various formulations, and the application is to this
It is not particularly limited.
Below in conjunction with the embodiment in the present invention, the technical scheme in the present invention is clearly and completely described.It is aobvious
So, described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based on the reality in the present invention
Example is applied, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, is all belonged to
In the scope of protection of the invention.
Embodiment 1
By weight, the raw material for treating the Chinese medicine composition of constipation is：3 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 2 parts of mulberry fruit, Semen sesami nigrum 2
Part, 3 parts of dried orange peel, 2 parts of folium sennae, 3 parts of black tea, 4 parts of saline cistanche, 3 parts of cynomorium songaricum, 2 parts of moleplant seed, 1 part of lepidium seed.
After above-mentioned raw materials are mixed, 30min is soaked with 200 parts of water, heats 1h, the supernatant of filtering after immersion at 100 DEG C
Liquid and precipitation.Take precipitation to repeat the operation 1 time of above-mentioned immersion, heating, filtering, merge the supernatant for extracting to obtain twice, produce
Extract solution.
Extract solution is concentrated under reduced pressure into relative density 1.0~1.2 (60 DEG C of thermal measurements) under the conditions of 60 DEG C, -0.05MPa,
The low-temperature vacuum drying 4h under conditions of 60 DEG C, -0.05MPa vacuums, crushed after being dried obtain dry powder to 18~20 mesh.
1 part of dry powder, 0.4 part of starch and 0.4 part of dextrin mixing are taken, adds 0.72 part of ethanol of mass fraction 90% as wetting
Agent, 20 mesh sieves are crossed after well mixed wet grain is made, whole grain after being dried at 65 DEG C, be packed as 3g/ bags, produce of Chinese medicine composition
Granula.
Embodiment 2
By weight, the raw material for treating the Chinese medicine composition of constipation is：：4 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 3 parts of mulberry fruit, Semen sesami nigrum 2
Part, 2 parts of dried orange peel, 1 part of folium sennae, 3 parts of black tea, 3 parts of moleplant seed, 1 part of lepidium seed.
Mixed after above-mentioned raw materials are crushed into 60 mesh respectively, soak 45min with 114 parts of water, heated after immersion at 95 DEG C
1.5h, the supernatant and precipitation of filtering.Take precipitation to repeat the operation 2 times of above-mentioned immersion, heating, filtering, merge 3 extractions and obtain
Supernatant, produce extraction solution.
Extract solution is concentrated under reduced pressure into relative density 1.0~1.2 (60 DEG C of thermal measurements) under the conditions of 65 DEG C, -0.06MPa,
The low-temperature vacuum drying 3h under conditions of 55 DEG C, -0.05MPa reciprocal of duty cycles, crushed after being dried obtain dry powder to 20 mesh.Dry powder is pressed
Packed according to the specification of 2.2~2.8g/ bags, the tea bag of Chinese medicine composition is made.
Instructions of taking：Soak and make tea-drinking.
Embodiment 3
By weight, the raw material for treating the Chinese medicine composition of constipation is：8 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 8 parts of mulberry fruit, Semen sesami nigrum 4
Part, 4 parts of dried orange peel, 8 parts of folium sennae, 4 parts of black tea, 1 part of cynomorium songaricum, 6 parts of moleplant seed, 6 parts of lepidium seed.
After above-mentioned raw materials are mixed, 15min is soaked with 490 parts of water, heats 0.5h, the supernatant of filtering after immersion at 90 DEG C
Liquid and precipitation.Take precipitation to repeat the operation 3 times of above-mentioned immersion, heating, filtering, merge the supernatant for extracting to obtain three times, produce
Extract solution.
Extract solution is concentrated under reduced pressure into relative density 1.0~1.2 (60 DEG C of thermal measurements) under the conditions of 60 DEG C, -0.04MPa,
The low-temperature vacuum drying 4h under conditions of 65 DEG C, -0.06MPa vacuums, crushed after being dried obtain dry powder to 18~20 mesh.Will
Dry powder loads capsule according to the specification of 0.5g/ grains, produces the capsule of Chinese medicine composition.
Instructions of taking：Three times a day taken with warm water, 3 tablets each time.
Embodiment 4
Clinical treatment is carried out to 355 constipation patients with Chinese medicine composition provided by the invention, to show Chinese medicine composition
Treat the clinical efficacy of constipation.
【General information】
Treatment group 355, wherein man 132, female 223；Less than 30 years old 79,31 years old~40 years old 33,41 years old 88,
- 60 years old 51 years old 56, -70 years old 61 years old 53, more than 70 years old 46.
【Diagnostic criteria】
1. the infrequent defecation time exceedes the custom of oneself more than 1 day, or defecation time interval more than 3 days twice.
2. dry and hard excrement.
3. defecation is laborious, feel not to the utmost with defecation discomfort or pain or defecation.
4. exclude organic constipation through whole body physical examination and physics and chemistry or special examined.
4.+any one of 3. 1. 2. the duration can set up diagnosis more than 2 weeks.
【Treatment method】
Treatment group takes after mixing it with water after meal each taking 1 bag of Chinese medicine composition made from embodiment 1.Patients with mild daily 1
Bag, daily 2 bag of severe patient.
Treatment group continuously takes 3 weeks.
【Treatment is formulated and result】Treatment is formulated and result
Treatment is formulated
1st, effective (same day or next day defecation be not once, difficult, becomes shape, and simultaneous phenomenon disappears substantially)
2nd, effectively (defecation is not once, difficult in 3 days, becomes shape, and simultaneous phenomenon makes moderate progress)
3rd, invalid (defecation or difficult defecation, simultaneous phenomenon are not improved yet within more than 3 days).
Observe result：
Treatment group 355, clinical effective 323, account for 91.1%；Effective 23, account for 6.4%；No effect 9,2.5% is accounted for,
Total effective rate 97.5%.
As can be seen here, traditional Chinese medicine composition for treating constipation total effective rate provided by the invention reaches 97.5%, and obvious effective rate is
91.1%, it is evident in efficacy to constipation, take and easy to carry, patient compliance height.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for treating constipation, by weight, it is made by the raw material including following components through water extraction：1~8
Part RADIX POLYGONI MULTIFLORI PREPARATA, 1~8 part of mulberries, 1~8 portion of Semen sesami nigrum, 1~4 part of dried orange peel, 0.5~8 portion of folium sennae, 1~4 part of black tea, 1~6 part
Moleplant seed and 0.5~3 part of lepidium seed.
2. Chinese medicine composition according to claim 1, it is characterised in that the raw material includes 3~4 parts of RADIX POLYGONI MULTIFLORI PREPARATAs, 2~3
Part mulberries, 2~4 portions of Semen sesami nigrums, 2~3 parts of dried orange peels, 1~2 portion of folium sennae, 2~3 parts of black tea, 2~3 parts of moleplant seeds and 1~2 part of Roripa
Li.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that by weight, the raw material also includes 2
One or both of~7 saline cistanches and 1~6 part of cynomorium songaricum.
4. Chinese medicine composition according to claim 3, it is characterised in that the raw material includes 3~4 portions of saline cistanches and 2
~3 parts of cynomorium songaricums.
5. Chinese medicine composition according to claim 1 or 2, it is characterised in that the formulation of the Chinese medicine composition be tablet,
Granule, capsule, effervescent agent or tea bag.
6. the preparation method of Chinese medicine composition, comprises the following steps described in Claims 1 to 4 any one：
(1) proportionally raw material is mixed, heating extraction after being soaked with water, filtered, obtain extracting solution；
(2) the extraction solution that the step (1) obtains is concentrated, crushed after being dried, obtains Chinese medicine composition.
7. preparation method according to claim 6, it is characterised in that the step of extraction solution is prepared in the step (1)
For：By mixed raw material with water soak 15~45min, after immersion at 90~100 DEG C 0.5~2h of heating extraction, will heat
Gained mixed liquor filtering afterwards, obtains supernatant and precipitation；The precipitation is repeated into above-mentioned immersion, heating extraction and filtering behaviour
Make, merge filtering gained supernatant every time, produce extraction solution.
8. preparation method according to claim 6, it is characterised in that step (2) the concentration extraction solution to 60 DEG C of heat
The relative density of measure is 1.0~1.2.
9. preparation method according to claim 6, it is characterised in that dried in the step (2) to be dried in vacuo, it is described
Vacuum drying condition is：45~65 DEG C, vacuum -0.09~-0.04MPa.
10. preparation method according to claim 6, it is characterised in that also include crushing after crushing in the step (2)
The dry granulation obtained afterwards.
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| CN114668799A (en) * | 2022-04-26 | 2022-06-28 | 武汉同济现代医药科技股份有限公司 | Preparation process and component identification and detection method of laxative traditional Chinese medicine |
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| CN114668799A (en) * | 2022-04-26 | 2022-06-28 | 武汉同济现代医药科技股份有限公司 | Preparation process and component identification and detection method of laxative traditional Chinese medicine |
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