CN107625113A - A kind of lozenge for improving immunity, supplementing energy and preparation method thereof - Google Patents
A kind of lozenge for improving immunity, supplementing energy and preparation method thereof Download PDFInfo
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- CN107625113A CN107625113A CN201710796397.3A CN201710796397A CN107625113A CN 107625113 A CN107625113 A CN 107625113A CN 201710796397 A CN201710796397 A CN 201710796397A CN 107625113 A CN107625113 A CN 107625113A
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Abstract
The invention discloses a kind of lozenge for improving immunity, supplementing energy and preparation method thereof, lozenge of the present invention is prepared by following raw material：20~30 parts of milk albumin powder, 12~18 parts of Reishi sporule freeze-dried powders, 12~18 parts of chlorella extracts, 45~65 parts of pearl freeze-dried powders living.Reishi sporule of the present invention and pearl living use lyophilized technique, have pure natural property, retain bioactive ingredients, ensure the integrality of raw material.While tens kinds of nutriments such as abundant proteins,vitamins,minerals and organized enzyme are provided, Reishi sporule, small algae ball and pearl synergy living, with invigorating heart gas, bowl spares, strengthening the essence gas health-care effect, while energy is supplemented, reach raising immunity, improve the ability that human body resists disease.
Description
Technical field
The present invention relates to health product technology field, more particularly to a kind of lozenge for improving immunity, supplementing energy and its
Preparation method.
Background technology
Immunity is the defense mechanism of human body itself, is virus and the bacterium of human bioequivalence and the external intrusion of elimination, handles
Aging, damage, the cell of death, and identification and the ability of processing vivo mutations cell and virus infected cell, immunity are low
Under body be easy to infected or cancer stricken；A variety of causes prevents immune system from normally playing protective effect, easily causes thin
Bacterium, virus, fungi etc. infect, liable to illness, if often ill, can aggravate the consumption of body, cause to have a delicate constitution, nutrition not
Good, One's spirits are drooping, fatigue and weak, appetite reduction etc., serious immunity degradation can also induce major disease.
With the rapid development of modern industrial civilization, on the surface, the living standard of people increasingly improves, still, people
The living environment of class constantly deteriorates, environmental pollution, food pollution getting worse, plus fast pace, high pressure, irregular life
Mode, people's nutrient imbalance, toxin is set constantly to accumulate, each dysfunction of organ of body, immunity degradation, various chronic diseases are dived
Volt, serious threat health of people, and the presence of sub-health state more comes by public concern, in the market also has various raising immunity
Health products exist, but its formula and effect differ, majority exist composition is more, price height, the shortcomings of effect is not fully up to expectations.
Through reading up the literature, ganoderma lucidum, small algae ball, pearl living all confirm there is clear and definite strengthen immunity work(by numerous studies document
The composition of energy, with small algae ball and the most study of ganoderma lucidum.In terms of strengthen immunity mechanism, ganoderma lucidum is with the Radix Astragali with the effect of polysaccharide
Based on.The purpose of this recipe determination is to study on the basis of ganoderma lucidum, after small algae ball extract and pearl composition living
Whether there is more preferable strengthen immunity function.
The content of the invention
In view of the shortcomings of the prior art, the invention provides a kind of lozenge for improving immunity, supplementing energy and its preparation
Method.
Specifically, the present invention is realized by following technical scheme：
The present invention provides a kind of lozenge for improving immunity, supplementing energy, is made up of following raw material：20~30 parts
Milk albumin powder, 12~18 parts of Reishi sporule freeze-dried powders, 12~18 parts of chlorella extracts, 45~65 parts of pearls living freeze
Powder.
Preferably, a kind of lozenge of the present invention, is made up of following raw material：24~28 parts of milk albumins
Powder, 14~16 parts of Reishi sporule freeze-dried powders, 14~16 parts of chlorella extracts, 50~60 parts of pearl freeze-dried powders living.
It is further preferred that a kind of lozenge of the present invention, is made up of following raw material：25 parts of milk albumins
Powder, 15 parts of Reishi sporule freeze-dried powders, 15 parts of chlorella extracts, 55 parts of pearl freeze-dried powders living.
Reishi sporule method for preparing freeze-dried powder of the present invention is：By Reishi sporule 15~45min of Ultrasonic Pulverization, with 30 mesh
Filtering, filtrate is loaded in freeze dryer pallet, be put into vacuum freezing drying oven freezer and carry out pre-freeze, at -50 DEG C of temperature
Keep 2~5h；By the good Reishi sporule of pre-freeze be transferred to dry storehouse carry out lyophilization, slowly heating, vacuum be 40~
70Pa, keep 6~8h；Continue heating and carry out parsing-desiccation, vacuum is maintained 10~30Pa, ganoderma lucidum is obtained after 2~5h
Spore freeze-dried powder.
Small algae ball method for preparing freeze-dried powder of the present invention is：After small algae ball cleaning, add 1~3 times of amount water, entered with medicine processing device
Row demulcen, handled through tunnel microwave dryer, 18~20kw of microwave power, line speed 2m/min, medicinal material after broken wall
Put into extractor, add 2~5 times of water, extract 2~5 hours, extract 2~4 times, merge extract solution, be concentrated into the 1/ of original volume
2, filtered with inorganic ceramic membrane, the rate of filtration is 8~12L/h, collects filtrate, be concentrated into relative density is at 60 DEG C
1.10~1.25, it is dried in vacuo, crushes, obtain small algae ball extract.
Pearl method for preparing freeze-dried powder living of the present invention is：Pearl living is shelled, cleaned, Pasteur kills at 60-70 DEG C
Bacterium 30min, crush and mix, load in freeze dryer pallet, be put into vacuum freezing drying oven freezer and carry out pre-freeze, temperature-
2~5h is kept at 50 DEG C；The good work pearl of pre-freeze is transferred to dry storehouse and carries out lyophilization, slowly heating, vacuum 40
~70Pa, keep 6~8h；Continue heating and carry out parsing-desiccation, vacuum is maintained 10~30Pa, must be living after 2~5h
Pearl freeze-dried powder.
Present invention also offers a kind of preparation method for preparing described lozenge, comprise the following steps：By milk albumin
Powder, Reishi sporule freeze-dried powder, chlorella extract, pearl freeze-dried powder living are well mixed, and it is 65% to add concentration expressed in percentage by volume
Ethanol water is wetting agent, wet granular processed, between drying to moisture reaches 2%~4% at 60 DEG C, crosses 18 mesh sieve whole grains and is total to
Tabletting produces after mixed.
The present invention at least have it is following a little and beneficial effect：
1st, present invention supplement energy, the lozenge of raising immunity, milk albumin powder, Reishi sporule freeze-dried powder, chlorella
The effect of extract and pearl etc. of living all emerges from, and by the proportioning of special ratios, has in supplement energy, raising immunity
There is the effect of Synergistic.Product composition is pure natural product, and is had no toxic side effect, and without according to lazyness, edible safety is reliable, protection
Health, improve the quality of living.
2nd, especially the invigorating heart gas of Reishi sporule freeze-dried powder, bowl spares, the health-care effect performance of strengthening the essence gas are obvious
3rd, chlorella extract contains more than ten kinds of amino acid needed by human body and the HDL of high level, exclusive
The compositions such as CGF, supplement it is various should composition simultaneously, have it is strong to immune function of human body adjustment effect.
4th, detected through scientific method, " pearl living " is rich in rich in trip amino acid and a variety of bio-hormones, particularly embryo liquid
Active ecological nutrient, is easily absorbed by human body.Often edible " pearl living ", can be significantly improved caused by asthenia of qi and blood loses
A variety of symptoms, strengthen body immunity and resistance, nourish beauty treatment, health body-building.
The present invention be using milk albumin powder, Reishi sporule freeze-dried powder, chlorella extract and pearl freeze-dried powder living as
A kind of nutraceutical prepared by primary raw material, the characteristics of above-mentioned four kinds of raw materials are due to itself, different effects is played, by specific
The formula rate of scope, has the function that Synergistic, to keep the pure natural characteristic of product, is not adding the bar of other auxiliary materials
Under part, while take into account the agreeable to the taste sense for reaching certain and peculiar flavour.The proportioning of the various raw materials of necessary Reasonable adjustment, first to the above
The proportioning of raw material is studied.
Ganoderma lucidum content determination of Chinese Pharmacopoeia 2010 edition is employed, GL-B is with DEXTROSE ANHYDROUS in detection lozenge
(C6H12O6) count, 0.50% must not be less than.The melting of lozenge is examined according to the A disintegration time limiteds of annex of Chinese Pharmacopoeia 2010 edition Ⅻ
Look into method inspection.
Proportioning 1：18kg milk albumins powder, 10kg Reishi sporules freeze-dried powder, 10kg chlorella extracts, 40kg work pearls
Freeze-dried powder, it is prepared by the method for embodiment 1.
Proportioning 2：31kg milk albumins powder, 20kg Reishi sporules freeze-dried powder, 20kg chlorella extracts, 66kg work pearls
Freeze-dried powder, it is prepared by the method for embodiment 2.
Proportioning 3:18kg milk albumins powder, 20kg Reishi sporules freeze-dried powder, 10kg chlorella extracts, 60kg work pearls
Freeze-dried powder, it is prepared by the method for embodiment 3.
The raw material Selection experiment result of table 1
As shown in Table 1, the lozenge of 1-3 of embodiment of the present invention formula rates, which contains GL-B composition and is above comparative example, matches somebody with somebody
Square 1-3 content, and melting is preferable, is dissolved within 5 minutes, and it is unstable to match 1-3 meltings, dissolve it is too fast or
Time is longer.
Embodiment
Embodiment 1
Prescription：20kg milk albumins powder, 12kg Reishi sporules freeze-dried powder, 12kg chlorella extracts, 45kg work pearls
Freeze-dried powder
Preparation method:
(1) by Reishi sporule Ultrasonic Pulverization 15min, filtered with 30 mesh, filtrate is loaded in freeze dryer pallet, is put into vacuum
Pre-freeze is carried out in freeze drying box freezer, 2h is kept at -50 DEG C of temperature；The good Reishi sporule of pre-freeze is transferred to dry storehouse
Lyophilization is carried out, slowly heating, vacuum is 40~70Pa, keeps 6h；Continue heating and carry out parsing-desiccation, tie up vacuum
Hold in 10~30Pa, Reishi sporule freeze-dried powder is obtained after 2h.
(2) small algae ball method for preparing freeze-dried powder is：After small algae ball cleaning, add 1 times of amount water, carry out demulcen with medicine processing device, pass through
Tunnel microwave dryer is handled, 18~20kw of microwave power, line speed 2m/min, and medicinal material puts into extractor after broken wall
In, 2 times of water are added, are extracted 2 hours, are extracted 2 times, merges extract solution, is concentrated into the 1/2 of original volume, is carried out with inorganic ceramic membrane
Filtering, the rate of filtration is 8~12L/h, collects filtrate, and it is 1.10~1.25 at 60 DEG C to be concentrated into relative density, vacuum drying,
Crush, obtain small algae ball extract.
(3) pearl method for preparing freeze-dried powder living is：Pearl living is shelled, cleaned, the pasteurize 30min at 60-70 DEG C,
It is broken to mix, load in freeze dryer pallet, be put into vacuum freezing drying oven freezer and carry out pre-freeze, protected at -50 DEG C of temperature
Hold 2h；The good work pearl of pre-freeze is transferred to dry storehouse and carries out lyophilization, slowly heating, vacuum is 40~70Pa, is kept
6h；Continue heating and carry out parsing-desiccation, vacuum is maintained 10~30Pa, must live pearl freeze-dried powder after 2h.
(4) milk albumin powder, Reishi sporule freeze-dried powder, chlorella extract, pearl freeze-dried powder living are well mixed, added
It is wetting agent to enter the ethanol water that concentration expressed in percentage by volume is 65%, wet granular processed, dried at 60 DEG C to moisture reach 2%~
Between 4%, cross tabletting after 18 mesh sieve whole grains are blended and produce.
Embodiment 2
Prescription：30kg milk albumins powder, 18kg Reishi sporules freeze-dried powder, 18kg chlorella extracts, 65kg work pearls
Freeze-dried powder.
Preparation method：
(1) by Reishi sporule Ultrasonic Pulverization 45min, filtered with 30 mesh, filtrate is loaded in freeze dryer pallet, is put into vacuum
Pre-freeze is carried out in freeze drying box freezer, 5h is kept at -50 DEG C of temperature；The good Reishi sporule of pre-freeze is transferred to dry storehouse
Lyophilization is carried out, slowly heating, vacuum is 40~70Pa, keeps 8h；Continue heating and carry out parsing-desiccation, tie up vacuum
Hold in 10~30Pa, Reishi sporule freeze-dried powder is obtained after 5h.
(2) small algae ball method for preparing freeze-dried powder is：After small algae ball cleaning, add 3 times of amount water, carry out demulcen with medicine processing device, pass through
Tunnel microwave dryer is handled, 18~20kw of microwave power, line speed 2m/min, and medicinal material puts into extractor after broken wall
In, 5 times of water are added, are extracted 5 hours, are extracted 4 times, merges extract solution, is concentrated into the 1/2 of original volume, is carried out with inorganic ceramic membrane
Filtering, the rate of filtration is 8~12L/h, collects filtrate, and it is 1.10~1.25 at 60 DEG C to be concentrated into relative density, vacuum drying,
Crush, obtain small algae ball extract.
(3) pearl method for preparing freeze-dried powder living is：Pearl living is shelled, cleaned, the pasteurize 30min at 60-70 DEG C,
It is broken to mix, load in freeze dryer pallet, be put into vacuum freezing drying oven freezer and carry out pre-freeze, protected at -50 DEG C of temperature
Hold 2~5h；The good work pearl of pre-freeze is transferred to dry storehouse and carries out lyophilization, slowly heating, vacuum is 40~70Pa, is protected
Hold 6~8h；Continue heating and carry out parsing-desiccation, vacuum is maintained 10~30Pa, the pearl that must be lived after 2~5h freezes
Powder.
(4) milk albumin powder, Reishi sporule freeze-dried powder, chlorella extract, pearl freeze-dried powder living are well mixed, added
It is wetting agent to enter the ethanol water that concentration expressed in percentage by volume is 65%, wet granular processed, dried at 60 DEG C to moisture reach 2%~
Between 4%, cross tabletting after 18 mesh sieve whole grains are blended and produce.
Embodiment 3:
Prescription：25kg milk albumins powder, 15kg Reishi sporules freeze-dried powder, 15kg chlorella extracts, 55kg work pearls
Freeze-dried powder.
Preparation technology:
(1) by Reishi sporule Ultrasonic Pulverization 30min, filtered with 30 mesh, filtrate is loaded in freeze dryer pallet, is put into vacuum
Pre-freeze is carried out in freeze drying box freezer, 4h is kept at -50 DEG C of temperature；The good Reishi sporule of pre-freeze is transferred to dry storehouse
Lyophilization is carried out, slowly heating, vacuum is 40~70Pa, keeps 7h；Continue heating and carry out parsing-desiccation, tie up vacuum
Hold in 10~30Pa, Reishi sporule freeze-dried powder is obtained after 3h.
(2) small algae ball method for preparing freeze-dried powder is：After small algae ball cleaning, add 2 times of amount water, carry out demulcen with medicine processing device, pass through
Tunnel microwave dryer is handled, 18~20kw of microwave power, line speed 2m/min, and medicinal material puts into extractor after broken wall
In, 3 times of water are added, are extracted 3 hours, are extracted 3 times, merges extract solution, is concentrated into the 1/2 of original volume, is carried out with inorganic ceramic membrane
Filtering, the rate of filtration is 8~12L/h, collects filtrate, and it is 1.10~1.25 at 60 DEG C to be concentrated into relative density, vacuum drying,
Crush, obtain small algae ball extract.
(3) pearl method for preparing freeze-dried powder living is：Pearl living is shelled, cleaned, the pasteurize 30min at 60-70 DEG C,
It is broken to mix, load in freeze dryer pallet, be put into vacuum freezing drying oven freezer and carry out pre-freeze, protected at -50 DEG C of temperature
Hold 4h；The good work pearl of pre-freeze is transferred to dry storehouse and carries out lyophilization, slowly heating, vacuum is 40~70Pa, is kept
7h；Continue heating and carry out parsing-desiccation, vacuum is maintained 10~30Pa, must live pearl freeze-dried powder after 3h.
(4) milk albumin powder, Reishi sporule freeze-dried powder, chlorella extract, pearl freeze-dried powder living are well mixed, added
It is wetting agent to enter the ethanol water that concentration expressed in percentage by volume is 65%, wet granular processed, dried at 60 DEG C to moisture reach 2%~
Between 4%, cross tabletting after 18 mesh sieve whole grains are blended and produce.
Embodiment 4
Prescription：20kg milk albumins powder, 12kg Reishi sporules freeze-dried powder, 18kg chlorella extracts, 65kg work pearls
Freeze-dried powder
Preparation method is the same as embodiment 1
Embodiment 5
Prescription：30kg milk albumins powder, 18kg Reishi sporules freeze-dried powder, 12kg chlorella extracts, 45kg work pearls
Freeze-dried powder
Preparation method is the same as embodiment 2
Embodiment 6
Prescription：24kg milk albumins powder, 14kg Reishi sporules freeze-dried powder, 16kg chlorella extracts, 60kg work pearls
Freeze-dried powder
Preparation method is the same as embodiment 3
Embodiment 7
Prescription：28kg milk albumins powder, 16kg Reishi sporules freeze-dried powder, 14kg chlorella extracts, 50kg work pearls
Freeze-dried powder
Preparation method is the same as embodiment 1
For the present invention will be further described, inventor carries out following pharmacodynamics test to lozenge of the present invention：
1st, material and method
The preparation prepared in 1.1 tested material embodiments 1~3.
1.2 experimental animal
Healthy Kunming kind female small white mouse 80, body weight 16-20g are provided by Guizhou medical university Experimental Animal Center.With
Machine is divided into 4 groups, every group 20.Uniformly give normal laboratory feeding conditions.
1.3 zoopery room environmentals
22 DEG C of temperature, humidity 45%.
1.4 dosage choice
The recommended dose of the health-care preparation (is calculated) 2g for adult by body weight 60kg, by 10 times of human body recommended amounts to small
Mouse is administered, and three groups of tested materials are configured to required concentration with physiological saline respectively, and mouse stomach determines every after being administered 30 days
Index, gastric infusion volume are 0.1ml/10g.Simultaneously set a blank control group, with physiological saline replace tested material carry out to
Medicine, gavage volume are identical with tested material.
1.5 experimental method
1.5.1ConA the mouse spleen lymphocyte transformation experiment induced
After administration 30 days, every group randomly selects 10 mouse, sterile to mouse progress to take spleen, and single cell suspension is made,
It is 3 × 10 with RPMI1640 complete mediums regulation cell concentration6/ml.The cell suspension of gained is added to 24 hole cell trainings
Support in plate, per hole 1mL, every kind of splenocyte suspension adds holes, adds 75 μ L ConA liquid per hole in addition, and another hole adds equal amount
Physiological saline, put 5%, 37 DEG C of CO272h is cultivated in incubator.Culture terminates preceding 4h, gently sucks supernatant 0.7mL per hole, adds
Enter 0.7mL and be free of the RPMI1640 nutrient solutions of calf serum, while add the μ L/ holes of MTT (5mg/mL) 50, continue to cultivate 4h.Training
Support after terminating, 1mL acid isopropyl alcohol is added per hole, piping and druming mixes, and is completely dissolved purple crystal, is then dispensed into the culture of 96 holes
In plate, 3 parallel holes are made in each hole, with the OD value at ELIASA measure 570nm.Experimental result is as shown in table 1,
The mouse spleen lymphocyte transformation experiment of table 2ConA inductions
From table 2 it can be seen that in three embodiment groups there is significant difference (p in absorbance difference with control group<
0.01).But absorbance difference and marked difference is not present between three kinds of different preparation groups.
1.5.2 influence of the health-care preparation to mouse immune organ is studied
It is administered the 25th day in mouse stomach, every group takes 10 mouse at random, takes mouse immune device, weighs, as a result such as the institute of table 3
Show：
Influence of the table 3 to mouse immune organ weight's index
Compared with negative control group, p<0.05, illustrate that the health-care preparation has the effect for the immunity that increases significantly.
Although above the present invention is made to retouch in detail with general explanation, embodiment and experiment
State, but on the basis of the present invention, some modifications can be made to it or are improved, this is aobvious and easy to those skilled in the art
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (7)
1. a kind of lozenge for improving immunity, supplementing energy, it is characterised in that be made up of following raw material：20~30 parts
Milk albumin powder, 12~18 parts of Reishi sporule freeze-dried powders, 12~18 parts of chlorella extracts, 45~65 parts of pearls living freeze
Powder.
2. a kind of lozenge according to claim 1, it is characterised in that be made up of following raw material：24~28 portions of oxen
PURE WHEY, 14~16 parts of Reishi sporule freeze-dried powders, 14~16 parts of chlorella extracts, 50~60 parts of pearl freeze-dried powders living.
3. a kind of lozenge according to claim 1, it is characterised in that be made up of following raw material：25 parts of bovine wheys
Albumen powder, 15 parts of Reishi sporule freeze-dried powders, 15 parts of chlorella extracts, 55 parts of pearl freeze-dried powders living.
A kind of 4. lozenge according to claim 1, it is characterised in that：The Reishi sporule method for preparing freeze-dried powder is：Will
Reishi sporule 15~45min of Ultrasonic Pulverization, filtered with 30 mesh, filtrate is loaded in freeze dryer pallet, is put into vacuum freeze drying
Pre-freeze is carried out in case freezer, 2~5h is kept at -50 DEG C of temperature；The good Reishi sporule of pre-freeze is transferred into dry storehouse to carry out
Lyophilization, slowly heating, vacuum is 40~70Pa, keeps 6~8h；Continue heating and carry out parsing-desiccation, tie up vacuum
Hold in 10~30Pa, Reishi sporule freeze-dried powder is obtained after 2~5h.
A kind of 5. lozenge according to claim 1, it is characterised in that：The small algae ball method for preparing freeze-dried powder is：Small algae
After ball cleaning, add 1~3 times of amount water, carry out demulcen with medicine processing device, handled through tunnel microwave dryer, microwave power 18~
20kw, line speed 2m/min, after broken wall in medicinal material input extractor, 2~5 times of water are added, are extracted 2~5 hours, extraction 2
~4 times, merge extract solution, be concentrated into the 1/2 of original volume, filtered with inorganic ceramic membrane, the rate of filtration is 8~12L/h, is received
Collect filtrate, it is 1.10~1.25 at 60 DEG C to be concentrated into relative density, is dried in vacuo, and crushes, obtains small algae ball extract.
A kind of 6. lozenge according to claim 1, it is characterised in that：The pearl method for preparing freeze-dried powder living is：Will be living
Pearl shells, and cleans, the pasteurize 30min at 60-70 DEG C, crushes and mixes, and loads in freeze dryer pallet, is put into vacuum refrigeration
Pre-freeze is carried out in drying box freezer, 2~5h is kept at -50 DEG C of temperature；The good work pearl of pre-freeze is transferred into dry storehouse to enter
Row lyophilization, slowly heating, vacuum is 40~70Pa, keeps 6~8h；Continue heating and carry out parsing-desiccation, make vacuum
10~30Pa is maintained, must live pearl freeze-dried powder after 2~5h.
7. a kind of preparation method for preparing the lozenge described in claim 1, it is characterised in that comprise the following steps：By bovine whey
Albumen powder, Reishi sporule freeze-dried powder, chlorella extract, pearl freeze-dried powder living are well mixed, and are added concentration expressed in percentage by volume and are
65% ethanol water is wetting agent, wet granular processed, between drying to moisture reaches 2%~4% at 60 DEG C, crosses 18 mesh sieves
Tabletting produces after whole grain blending.
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| CN108771219A (en) * | 2018-05-31 | 2018-11-09 | 杨秀丽 | Eat leaf grass plant protein nutrition lozenge and preparation method thereof |
| CN109090619A (en) * | 2018-07-25 | 2018-12-28 | 兴义市农丰农业发展有限公司 | A kind of clearing heat and detoxicating, supplement energy lozenge and preparation method thereof |
| CN113413458A (en) * | 2021-06-18 | 2021-09-21 | 贵州神奇药物研究院 | A pharmaceutical composition with antiaging effect, and its preparation method |
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| CN102028199A (en) * | 2010-11-08 | 2011-04-27 | 河南科技大学 | Health-care capsule of chicken embryo egg and processing technique thereof |
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Application publication date: 20180126 |
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