CN107616794A - A kind of disturbance of consciousness cerebral cortex condition detecting system and method - Google Patents
A kind of disturbance of consciousness cerebral cortex condition detecting system and method Download PDFInfo
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Abstract
The invention discloses a kind of disturbance of consciousness cerebral cortex condition detecting system, and it includes brain response signal synchronous collection module, reaction signal noise processed module and cerebral cortex state detection algorithm module.Reaction signal synchronous acquisition module includes transcranial magnetic stimulation and magnetic compatibility brain electric equipment；The brain electricity cap uses 64 passage high density brain electricity caps；The cerebral magnetic stimulation coil uses figure-eight coil, and in implementation process, coil is vertically positioned over patient's left dorsal lateral prefrontal (F3 electrode positions in 10 20 brain electric systems) with magnetic field with the direction of scalp.The present invention has filled up the blank of disturbance of consciousness cerebral cortex condition detecting system and method.Compared to the method for current clinical research, the advantage of the invention is that：It is economical, convenient, calculate simple, strong applicability, be adapted to clinical expansion etc..
Description
Technical field
The invention belongs to biomedical engineering field, is a kind of method based on engineering science and informatics specifically, uses
In the detection of disturbance of consciousness brain in patients cortex state feature.
Background technology
At present, the clinically disturbance of consciousness cortex condition detection method substantially without mature and reliable.The medical treatment in indivedual forward positions
Research institution has carried out the disturbance of consciousness cortical reaction based on tranquillization state brain electricity, event related potential and functional MRI technology
Property detection work.But above method has major defect, application of these methods in clinical practice govern.Specifically such as
Under：The existing detection method based on tranquillization state brain electricity must be based on large sample statistical result, can not provide individuation detection and refer to
Mark, therefore lack practicality.Existing event related potential detection method needs patient to possess complete perception, vision or the sense of hearing
Nerve pathway, partly need peripheral nerve path coordinate.And disturbance of consciousness patient generally has serious brain damage, it is difficult to protect
Complete corresponding nerve pathway, therefore this method narrow application range in clinic.Although functional MRI technology can provide individual
Change and judge, but the particularly preferred patient of cortex state can only be identified according to its result, and can not provide and be available for what doctor referred to
Quantize index, and this method complex operation, costly, it is impossible to be popularized in clinical practice.It is external at present, there is research to report
The road method similar to the present invention is used for the detection of disturbance of consciousness cortex state, that is, disturbs complexity index, but the algorithm
Extremely complex and calculating is time-consuming, it is difficult to is promoted in clinical practice.
The present invention gets down to method that is economic, convenient, calculating simple, strong applicability, be adapted to clinical expansion.Solve existing
The significant deficiency of method, it is adapted to clinical practice to use.
It is contemplated that a kind of system and method based on engineering science and informatics of exploitation, for disturbance of consciousness brain in patients
The detection of cortex state feature.
The content of the invention
In view of the shortcomings of the prior art, the present invention relates to a kind of system and method based on engineering science and informatics, it is used for
The detection of disturbance of consciousness brain in patients cortex state feature.
The method defect of prior art is specific as follows：The existing detection method based on tranquillization state brain electricity must be based on full-page proof
This statistical result, Detection results are low, can not provide individuation Testing index, therefore lack practicality.Existing event related potential
Detection method depends critically upon the nerve pathway of the perception of patient, vision or the sense of hearing, partly needs peripheral nerve path to coordinate,
Normal form is complicated, or even needs patient to cooperate with one's own initiative.And disturbance of consciousness patient generally has serious brain damage, it is difficult to save from damage corresponding
Nerve pathway and also the integrality of corresponding nerve pathway be difficult to assess, therefore this method narrow application range in clinic.Function
Although mr techniques can provide individuation judgement, the particularly preferred trouble of cortex state can only be identified according to its result
Person, and the index that quantizes for being available for doctor to refer to can not be provided, and this method complex operation, it is costly, it is necessary to which patient protects
It is static to hold head, it is impossible to popularized in clinical practice.It is external at present, studies have reported that the method similar to the present invention is used to anticipating
Know the detection of obstacle cortex state, that is, disturb complexity index, but the algorithm is extremely complex and calculates time-consuming, it is difficult to facing
Promoted in bed application.
The present invention gets down to method that is economic, convenient, calculating simple, strong applicability, be adapted to clinical expansion.Solves existing side
The significant deficiency of method, it is adapted to clinical practice to use.
To reach above-mentioned purpose, technical solution of the invention is a kind of system based on engineering science and informatics of design
And method, the detection for disturbance of consciousness brain in patients cortex state feature.
To solve Cost Problems, system of the invention uses the combination of transcranial magnetic stimulation and brain power technology, based on through cranium magnetic
Induced by Stimulation signal proposes cortex state computation algorithm, avoids, using nuclear magnetic data etc., significantly reducing cost.
Secondly, in order to solve annual reporting law computation complexity problem, cerebral cortex status monitoring algorithm proposed by the present invention calculates
Cerebral cortex induces the correlation between signal, induces correlation matrix extraction digitalization index based on full brain, multiple compared to disturbance
Miscellaneous degree index realizes the reduction of the calculating cost of decades of times.In terms of applicability, the present invention is directly real in the corresponding brain area of brain
The extraction of induction and induction signal now through cranium magnetic, it is not necessary to which patient's is actively engaged in, the peripheral nerve independent of patient
Path, low is required to the clinical condition of patient, can generally be used in impaired patients are realized.Meanwhile in order in clinic
Promoted in, this method provides the standardized index for representing brain in patients cortex state, clinical can provide and easily understand
Reference index, is easy to provide for clinical judgment and intuitively refers to.
The specific workflow of present system is as follows：
High density magnetic compatibility brain electricity cap is worn for patient, brain electricity cap is connected with eeg amplifier.Cerebral magnetic stimulation coil is tight
Patch scalp is positioned over brain electricity cap F3 electrode positions (corresponding to left dorsal lateral prefrontal).Then using transcranial magnetic stimulation with 2 to 4
The random interval of second triggers 200 pulses, and synchronous recording induces reaction signal.Collect induce reaction signal after to the signal
Carry out pretreatment and go the noise signal unless nerves reaction.Signal is induced based on the high density being disposed, uses cerebral cortex
State detection algorithm calculates cerebral cortex state index.Cerebral cortex state index be 0 to 1 between numerical value, numerical value higher generation
Table cerebral cortex state is better.In cerebral cortex state-detection, it is about 30 minutes to wear the brain electricity cap time, during examinations
Between be 10 minutes or so.
Advantages of the present invention：
The technical program is directly reacted using transcranial magnetic stimulation in cortex evoked brain potential, and cerebral cortex state-detection is calculated
Method is calculated based on the evoked brain potential, and whole implementation process is actively engaged in without patient, has thoroughly been broken away from logical to patient peripheral's nerve
The dependence of the clinical conditions such as road, cerebral cortex state-detection can be provided to more patients, applicability is wider.Due to this
The design of technical scheme uses evoked brain potential, compared to tranquillization state brain computator method, using the teaching of the invention it is possible to provide the testing result of individuation, easily
Understood in clinic, it is low compared to function nuclear-magnetism, simple equipments, consuming, it can implement to detect by bed.The technical program uses evoked brain potential
Signal of change correlation matrix represents the connectivity between brain in patients brain area, and normalized brain is calculated based on correlation matrix is induced
Cortex state index, nuclear magnetic data Source Tracing is used compared to existing similar approach disturbance complexity, the technical program is calculating
It is more efficient on algorithm.Therefore, the technical program is a kind of disturbance of consciousness brain in patients cortex state for being more suitable for clinical expansion
Detection method.
The present invention has filled up the blank of disturbance of consciousness cerebral cortex condition detecting system and method.Compared to current clinical research
Method, the advantage of the invention is that：It is economical, convenient, calculate simple, strong applicability, be adapted to clinical expansion etc..
Brief description of the drawings
Accompanying drawing 1：Disturbance of consciousness brain in patients cortex state detection algorithm general flow chart.
Accompanying drawing 2：Disturbance of consciousness brain in patients cortex state detection algorithm block diagram.
Accompanying drawing 3：One disturbance of consciousness brain in patients cortex state-detection result.
Accompanying drawing 4：Corresponding relation between cerebral cortex state index and disturbance of consciousness patient's level of consciousness.
Embodiment
Embodiments of the invention are described below in detail, the embodiment is only used for explaining the present invention, and it is not intended that right
The limitation of the present invention.
The specific embodiment of the present invention is as described below.
The technical program is directly reacted using transcranial magnetic stimulation in cortex evoked brain potential, and cerebral cortex state-detection is calculated
Method is calculated based on the evoked brain potential, and whole implementation process is actively engaged in without patient, has thoroughly been broken away from logical to patient peripheral's nerve
The dependence of the clinical conditions such as road, cerebral cortex state-detection can be provided to more patients, applicability is wider.Due to this
The design of technical scheme uses evoked brain potential, compared to tranquillization state brain computator method, using the teaching of the invention it is possible to provide the testing result of individuation, easily
Understood in clinic, it is low compared to function nuclear-magnetism, simple equipments, consuming, it can implement to detect by bed.The technical program uses evoked brain potential
Signal of change correlation matrix represents the connectivity between brain in patients brain area, and normalized brain is calculated based on correlation matrix is induced
Cortex state index, nuclear magnetic data Source Tracing is used compared to existing similar approach disturbance complexity, the technical program is calculating
It is more efficient on algorithm.Therefore, the technical program is a kind of disturbance of consciousness brain in patients cortex state for being more suitable for clinical expansion
Detection method.
As shown in Figure 1, the technical solution adopted by the present invention specific implementation includes three parts：Brain response signal is synchronously adopted
Collection, reaction signal noise processed and cerebral cortex state detection algorithm.
Reaction signal synchronous acquisition includes transcranial magnetic stimulation and magnetic compatibility brain electric equipment.Brain electricity cap is highly dense using 64 passages
Spend brain electricity cap.Cerebral magnetic stimulation coil uses figure-eight coil, and in implementation process, coil is put with direction of the magnetic field vertically with scalp
It is placed in patient's left dorsal lateral prefrontal (F3 electrode positions in 10-20 brain electric systems).It is 200 times to apply sum through cranium magnetic coil
Pulse, Inter-pulse interval is 2-4 second random intervals.200 evoked brain potential reaction signals of brain electric equipment synchronous acquisition.
Reaction signal noise processed uses spline interpolation, filtering process and independent composition analysis algorithm.Spline interpolation is removed
10 milliseconds of 20 milliseconds of data to after triggering before pulse-triggered.Filtering is filtered using FIR, and band logical 1-100Hz, and 45-55Hz are fallen into
Ripple.Independent component analysis extracts and separates the non-nerves reaction noise signal such as eye electricity, inducing myoelectric potential, power source charges noise.
Cerebral cortex state detection algorithm is as shown in Figure 2.Each high density induction signal is subtracted into baseline mean.Induce
It is divided into two parts in matrix computations：Baseline threshold matrix computations and induction mean matrix calculate., will when inducing mean matrix calculating
200 high density induce Signal averaging and are averaged, and it is 20 milliseconds to 500 milliseconds data after pulse that extraction, which induces signal,.Use correlation
Property algorithm calculate high density and induce when waiting correlation of the signal two-by-two between passage, formed and induce related mean matrix.Baseline threshold
Value matrix calculate when, by 200 induction signal background signals, i.e., 300 milliseconds to first 10 milliseconds before pulse, calculate etc. when correlation
Matrix.Using Bootstrap methods, value conduct pair of the correlation matrix 200 baseline correlations of each element in p=0.05 is calculated
Passage relevance threshold is answered, ultimately forms threshold matrix.Then, by obtained induction correlation mean matrix each element and threshold value square
Battle array corresponding element compares, and remains larger than the value of threshold matrix corresponding element, and other values are set to 0, and is formed and significantly induces correlation matrix.It is right
Significantly induce correlation matrix and calculate global synchronization index, as cerebral cortex state index.Accompanying drawing 3 illustrates a disturbance of consciousness
Induction correlation mean matrix and notable induction Correlation Moment in the high density evoked brain potential signal and cortex state algorithm of patient
The result of battle array, the cortex state index value of the final patient is 0.55.Accompanying drawing 4 illustrates, and is counted based on 64 passage high density brains electricity
Empirical relation between the cerebral cortex state index value and disturbance of consciousness patient's state of consciousness of calculation.It is right that the inventive method combines this
Should be related to can provide reference for clinician reviews disturbance of consciousness brain in patients cortex state and level of consciousness.
It should be noted that the preferred specific embodiment of the present invention is the foregoing is only,
If conception under this invention changes, its caused function, the spirit still covered without departing from specification
When, all should be within the scope of the invention.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or the spy for combining the embodiment or example description
Point is contained at least one embodiment or example of the present invention.In this manual, to the schematic representation of above-mentioned term not
Necessarily refer to identical embodiment or example.Moreover, specific features, structure, material or the feature of description can be any
One or more embodiments or example in combine in an appropriate manner.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not
In the case of departing from the principle and objective of the present invention a variety of change, modification, replacement and modification can be carried out to these embodiments, this
The scope of invention is limited by claim and its equivalent.
Claims (6)
- A kind of 1. disturbance of consciousness cerebral cortex condition detecting system, it is characterised in that：It includes brain response signal synchronous collection module, and reaction signal noise processed module and cerebral cortex state-detection are calculated Method module.
- 2. the detecting system described in claim 1, it is characterised in that：Reaction signal synchronous acquisition module includes transcranial magnetic stimulation and magnetic compatibility brain electric equipment；The brain electricity cap uses 64 passage high density brain electricity caps；The cerebral magnetic stimulation coil uses figure-eight coil, and in implementation process, coil is placed with direction of the magnetic field vertically with scalp In patient's left dorsal lateral prefrontal (F3 electrode positions in 10-20 brain electric systems).
- 3. the detecting system described in claim 1 or 2, it is characterised in that：Cerebral cortex state detection algorithm：Each high density induction signal is subtracted into baseline mean；Induce in matrix computations and be divided into two parts：Baseline threshold matrix Calculate and induce mean matrix and calculate.When inducing mean matrix calculating, 200 high density are induced into Signal averagings and are averaged, are extracted It is 20 milliseconds to 500 milliseconds data after pulse to induce signal；High density, which is calculated, using relevance algorithms induces signal passage two-by-two Between correlation when waiting, formed and induce related mean matrix；During baseline threshold matrix computations, by the base of 200 induction signals 300 milliseconds to first 10 milliseconds before line signal, i.e. pulse, calculate etc. when correlation matrix；Using Bootstrap methods, calculate related Value of the 200 baseline correlations of matrix each element in p=0.05 ultimately forms threshold value square as respective channel relevance threshold Battle array；Then, obtained induction correlation mean matrix each element is remained larger than into threshold matrix compared with threshold matrix corresponding element The value of corresponding element, other values are set to 0, and are formed and are significantly induced correlation matrix；Refer to significantly inducing correlation matrix calculating global synchronization Number, as cerebral cortex state index.
- 4. the detecting system described in claim any one of 1-3, it is characterised in that：Described to apply the pulse that sum is 200 times through cranium magnetic coil, Inter-pulse interval is 2-4 second random intervals.Brain electric equipment 200 evoked brain potential reaction signals of synchronous acquisition.
- 5. the detecting system described in claim any one of 1-4, it is characterised in that：The reaction signal noise processed uses spline interpolation, filtering process and independent composition analysis algorithm；Spline interpolation is removed 10 milliseconds of 20 milliseconds of data to after triggering before pulse-triggered.Filtering is filtered using FIR, and band logical 1-100Hz, and 45-55Hz are fallen into Ripple.Independent component analysis extracts and separates the non-nerves reaction noise signal such as eye electricity, inducing myoelectric potential, power source charges noise.
- 6. the detecting system described in claim any one of 1-5, it is characterised in that：Can further it be judged according to the data of acquisition.
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