CN107602714A - A kind of composite modified pregelatinized starch and preparation method thereof - Google Patents
A kind of composite modified pregelatinized starch and preparation method thereof Download PDFInfo
- Publication number
- CN107602714A CN107602714A CN201710967943.5A CN201710967943A CN107602714A CN 107602714 A CN107602714 A CN 107602714A CN 201710967943 A CN201710967943 A CN 201710967943A CN 107602714 A CN107602714 A CN 107602714A
- Authority
- CN
- China
- Prior art keywords
- pregelatinized starch
- mixture
- preparation
- composite modified
- modified pregelatinized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of composite modified pregelatinized starch and preparation method thereof, starch, chlorosulfonic acid and purified water are weighed, is inserted in high-speed mixer, mix 20 40min, the moisture for controlling starch after mixing is 10 20%, and mixture A is made；Salicylic acid, sodium alginate and xylitol are weighed, is mixed with mixture A, mixes 20 40min, mixture B is made；Sodium hypochlorite, APG are added, the 60min of stir process 15 at a temperature of 50 70 DEG C, is then added in extruder charging hopper, opens extruder, controls extruder temperature, is extruded, washing, is drying to obtain composite modified pregelatinized starch.The present invention substantially increases the dispersiveness and stability of pregelatinized starch, and homogeneity is good, meets pregelatinized starch in the other application of pharmaceutical grade.Preparation method of the present invention also has the advantages that equipment operation convenience, energy-conserving and environment-protective, production cost is low and product quality is easily controlled.
Description
Technical field
The present invention relates to starch conversion technical field, specifically a kind of composite modified pregelatinized starch and preparation method thereof.
Background technology
Pregelatinized starch is the derivative of starch, also known as amylum pregelatinisatum, belongs to the class of pharmaceutic adjuvant two.Pregelatinized starch is
Starch granules is partly or entirely ruptured by starch with chemical method or Mechanical Method and obtained, only its modified physical property, and it is original
Chemical constitution is simultaneously unchanged, therefore it has good mobility and compressibility, and also has good lubrication, can be with
Other auxiliary materials share the lubricant in direct powder compression, can also can be also used for capsule as the adhesive of wet granulation
The auxiliary material of other solid pharmaceutical preparations such as agent.Production pregelatinized starch is typically all to be prepared using wet method processing technology at present, is such as added
Hot method.But utilize the water soluble starch poor quality of this produced in conventional processes, narrow application range.It has developed height again in recent years
The methods of warm high pressure alcohol method, normal pressure polyol process, alcohol-alkaline process, alcohol-hydrochloric acid method, prepares water soluble starch, and these methods are also
Equipment requirement height be present, complex process, cause environmental pollution, product quality is difficult to control, and especially as pharmaceutic adjuvant, its is pre-
The problems such as gel degree is not easily controlled.
The content of the invention
It is an object of the invention to provide a kind of composite modified pregelatinized starch and preparation method thereof, to solve above-mentioned background
The problem of being proposed in technology.
To achieve the above object, the present invention provides following technical scheme：
A kind of preparation method of composite modified pregelatinized starch, comprises the following steps：
1) starch, chlorosulfonic acid and purified water are weighed, is inserted in high-speed mixer, 20-40min is mixed, is formed sediment after control mixing
The moisture of powder is 10-20%, and mixture A is made；
2) salicylic acid, sodium alginate and xylitol are weighed, is mixed with mixture A, mixes 20-40min, mixing is made
Thing B；
3) sodium hypochlorite, APG are weighed, is mixed with mixture B, the stir process 15- at a temperature of 50-70 DEG C
60min, mixture C is made；
4) mixture C is added in extruder charging hopper, opens extruder, control extruder temperature, at a certain temperature
Extruded, wash, be drying to obtain composite modified pregelatinized starch.
As the further scheme of the present invention：In step 1), the rotating speed of high-speed mixer is 400-600r/min.
As the further scheme of the present invention：In step 1), starch, the mass ratio of chlorosulfonic acid are 10-30: 1.
As the further scheme of the present invention：In step 2), salicylic acid, sodium alginate, xylitol, mixture A quality
Than for 3-10: 1-3: 1-3: 50-80.
As the further scheme of the present invention：In step 3), sodium hypochlorite, APG, mixture B mass ratio are
10-50∶1-5∶50-80。
As the further scheme of the present invention：In step 4), it is dried using freeze-drying.
As the further scheme of the present invention：In step 4), the heating-up temperature of extruder is 60-120 DEG C.
As the further scheme of the present invention：It is further comprising the steps of：Dried material is delivered into pelletizing on pelleter
Shaping, is crushed to required particle size range.
Another object of the present invention is to provide using composite modified pregelatinized starch made from the above method.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention uses simple technique, starch is handled using different raw materials, and addition condition is closed
Reason control, substantially increases the dispersiveness and stability of pregelatinized starch, homogeneity is good, meets pregelatinized starch in medicinal rank
Application.Preparation method of the present invention also has equipment operation convenience, energy-conserving and environment-protective, production cost is low and product quality is easily controlled
The advantages that.
Embodiment
Below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only part of the embodiment of the present invention, rather than whole embodiments.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under the premise of creative work is not made, all
Belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of preparation method of composite modified pregelatinized starch, comprise the following steps：
1) starch, chlorosulfonic acid and purified water are weighed, is inserted in high-speed mixer, mixes 20min, starch after control mixing
Moisture is 10%, and mixture A is made；The rotating speed of high-speed mixer is 400r/min, and starch, the mass ratio of chlorosulfonic acid are 10: 1.
2) salicylic acid, sodium alginate and xylitol are weighed, is mixed with mixture A, mixes 20min, mixture is made
B；Salicylic acid, sodium alginate, xylitol, mixture A mass ratio are 3: 1: 1: 50.
3) sodium hypochlorite, APG are weighed, is mixed with mixture B, the stir process 15min at a temperature of 50 DEG C, system
Obtain mixture C；Sodium hypochlorite, APG, mixture B mass ratio are 10: 1: 50.
4) mixture C is added in extruder charging hopper, opens extruder, extruder temperature is controlled, in 60 DEG C of temperature
Under extruded, wash, be dried using freeze-drying and produce composite modified pregelatinized starch.
Embodiment 2
In the embodiment of the present invention, a kind of preparation method of composite modified pregelatinized starch, comprise the following steps：
1) starch, chlorosulfonic acid and purified water are weighed, is inserted in high-speed mixer, mixes 40min, starch after control mixing
Moisture is 20%, and mixture A is made；The rotating speed of high-speed mixer is 600r/min, and starch, the mass ratio of chlorosulfonic acid are 30: 1.
2) salicylic acid, sodium alginate and xylitol are weighed, is mixed with mixture A, mixes 40min, mixture is made
B；Salicylic acid, sodium alginate, xylitol, mixture A mass ratio are 10: 3: 3: 80.
3) sodium hypochlorite, APG are weighed, is mixed with mixture B, the stir process 60min at a temperature of 50-70 DEG C,
Mixture C is made；Sodium hypochlorite, APG, mixture B mass ratio are 50: 5: 80.
4) mixture C is added in extruder charging hopper, opens extruder, extruder temperature is controlled, in 120 DEG C of temperature
Under extruded, wash, be dried using freeze-drying and produce composite modified pregelatinized starch.
Embodiment 3
In the embodiment of the present invention, a kind of preparation method of composite modified pregelatinized starch, comprise the following steps：
1) starch, chlorosulfonic acid and purified water are weighed, is inserted in high-speed mixer, mixes 30min, starch after control mixing
Moisture is 15%, and mixture A is made；The rotating speed of high-speed mixer is 500r/min, and starch, the mass ratio of chlorosulfonic acid are 20: 1.
2) salicylic acid, sodium alginate and xylitol are weighed, is mixed with mixture A, mixes 30min, mixture is made
B；Salicylic acid, sodium alginate, xylitol, mixture A mass ratio are 6: 2: 2: 65.
3) sodium hypochlorite, APG are weighed, is mixed with mixture B, the stir process 40min at a temperature of 60 DEG C, system
Obtain mixture C；Sodium hypochlorite, APG, mixture B mass ratio are 30: 3: 65.
4) mixture C is added in extruder charging hopper, opens extruder, extruder temperature is controlled, in 80 DEG C of temperature
Under extruded, wash, be dried using freeze-drying, dried material is delivered on pelleter into pelletizing is molded, powder
Particle size range needed for being broken to produces composite modified pregelatinized starch.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit requires rather than described above limits, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that those skilled in the art should for clarity
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (9)
1. a kind of preparation method of composite modified pregelatinized starch, it is characterised in that comprise the following steps：
1) starch, chlorosulfonic acid and purified water are weighed, is inserted in high-speed mixer, mixes 20-40min, starch after control mixing
Moisture is 10-20%, and mixture A is made；
2) salicylic acid, sodium alginate and xylitol are weighed, is mixed with mixture A, mixes 20-40min, mixture B is made；
3) sodium hypochlorite, APG are weighed, is mixed with mixture B, the stir process 15-60min at a temperature of 50-70 DEG C,
Mixture C is made；
4) mixture C is added in extruder charging hopper, opens extruder, controlled extruder temperature, carry out at a certain temperature
Extrusion, washing, is drying to obtain composite modified pregelatinized starch.
2. the preparation method of composite modified pregelatinized starch according to claim 1, it is characterised in that high in step 1)
The rotating speed of fast mixer is 400-600r/min.
3. the preparation method of composite modified pregelatinized starch according to claim 1, it is characterised in that in step 1), form sediment
Powder, the mass ratio of chlorosulfonic acid are 10-30: 1.
4. the preparation method of composite modified pregelatinized starch according to claim 1, it is characterised in that in step 2), water
Poplar acid, sodium alginate, xylitol, mixture A mass ratio are 3-10: 1-3: 1-3: 50-80.
5. the preparation method of composite modified pregelatinized starch according to claim 1, it is characterised in that secondary in step 3)
Sodium chlorate, APG, mixture B mass ratio are 10-50: 1-5: 50-80.
6. the preparation method of composite modified pregelatinized starch according to claim 1, it is characterised in that in step 4), adopt
It is dried with freeze-drying.
7. the preparation method of composite modified pregelatinized starch according to claim 1, it is characterised in that in step 4), squeeze
The heating-up temperature for going out machine is 60-120 DEG C.
8. the preparation method of composite modified pregelatinized starch according to claim 1, it is characterised in that also including following step
Suddenly：Dried material is delivered into pelletizing on pelleter to be molded, is crushed to required particle size range.
A kind of 9. composite modified pregelatinized starch made from preparation method using as described in claim 1-8 is any.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710967943.5A CN107602714A (en) | 2017-09-25 | 2017-09-25 | A kind of composite modified pregelatinized starch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710967943.5A CN107602714A (en) | 2017-09-25 | 2017-09-25 | A kind of composite modified pregelatinized starch and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107602714A true CN107602714A (en) | 2018-01-19 |
Family
ID=61078569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710967943.5A Pending CN107602714A (en) | 2017-09-25 | 2017-09-25 | A kind of composite modified pregelatinized starch and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107602714A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102952199A (en) * | 2012-10-16 | 2013-03-06 | 广西大学 | Composite modified pregelatinized starch and preparation method thereof |
| CN103773275A (en) * | 2012-10-20 | 2014-05-07 | 中国烟草总公司郑州烟草研究院 | Novel amyloid cigarette adhesive based on composite modified gelatinized starch |
| CN105968422A (en) * | 2016-05-24 | 2016-09-28 | 湖州展望药业有限公司 | Preparation technology of pregelatinized starch |
| CN106517849A (en) * | 2015-09-10 | 2017-03-22 | 绵阳莫仕科技有限公司 | Oxidation-sulfonation starch water reducing agent preparation method |
-
2017
- 2017-09-25 CN CN201710967943.5A patent/CN107602714A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102952199A (en) * | 2012-10-16 | 2013-03-06 | 广西大学 | Composite modified pregelatinized starch and preparation method thereof |
| CN103773275A (en) * | 2012-10-20 | 2014-05-07 | 中国烟草总公司郑州烟草研究院 | Novel amyloid cigarette adhesive based on composite modified gelatinized starch |
| CN106517849A (en) * | 2015-09-10 | 2017-03-22 | 绵阳莫仕科技有限公司 | Oxidation-sulfonation starch water reducing agent preparation method |
| CN105968422A (en) * | 2016-05-24 | 2016-09-28 | 湖州展望药业有限公司 | Preparation technology of pregelatinized starch |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102952199B (en) | Composite modified pregelatinized starch and preparation method thereof | |
| CN102977224B (en) | Method for preparing calcium alginate | |
| CN102134281A (en) | Method for producing high-flowability pregelatinized starch | |
| CN103599085B (en) | A kind of Aspirin Enteric-coated Tablets and preparation technology thereof | |
| CN104193834B (en) | A kind of preparation method of medicinal pregelatinized Starch | |
| CN103435708A (en) | Preparation method of nanometer amphoteric starch | |
| CN104059390A (en) | Modified calcium carbonate with high specific surface area and preparation method thereof | |
| CN103190529B (en) | Process for preparing deeply-cured compound feed for sucking pigs | |
| CN104399359A (en) | Medical carbon dioxide absorbent and preparation method thereof | |
| CN107602714A (en) | A kind of composite modified pregelatinized starch and preparation method thereof | |
| CN102077955B (en) | Soluble konjac dietary fiber tablets and preparation method thereof | |
| CN103142525A (en) | Olanzapine gastric soluble tablets and preparation method thereof | |
| CN108676317A (en) | A kind of preparation method of the ABS plastic with marble grain and antibacterial functions | |
| CN103320235A (en) | Particles containing sodium fatty acid methyl ester sulfonate and preparation method thereof | |
| CN104664386A (en) | Ultra-micronized powder maca tablet | |
| CN108148144A (en) | A kind of improvement of the preparation method of medicinal pregelatinized starch | |
| CN105694757A (en) | Preparation method of biological nano glue | |
| CN102641247B (en) | Acid and alkali neutralization granulating method of effervescent | |
| CN102161605B (en) | Hygroscopic catalyst and preparation method thereof | |
| CN107586402A (en) | A kind of preparation method of compound type starch | |
| CN104610582B (en) | A kind of full starch plant glue and its preparation method and application | |
| CN107236319A (en) | A kind of degradable bamboo is nanocomposite moulded and preparation method thereof | |
| CN109288952B (en) | Jingangteng pill and its preparing process | |
| CN107446384A (en) | A kind of preparation method of composite calcium carbonate | |
| CN113028740A (en) | Low-temperature drying device and method for pharmaceutic adjuvant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 277400 Residence of Malantun Town, Taierzhuang District, Zaozhuang City, Shandong Province Applicant after: Shandong Shenzhou Xiangyu Science and Technology Group Co., Ltd. Address before: 277400 Residence of Malantun Town, Taierzhuang District, Zaozhuang City, Shandong Province Applicant before: Shandong Shenzhou Xiangyu Technology Group Co., Ltd. |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180119 |