CN107596175A - A kind of medicine for treating asthma and preparation method thereof - Google Patents
A kind of medicine for treating asthma and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of medicine for treating asthma and preparation method thereof, the medicine is to be prepared by the Chinese medicine of following parts by weight for bulk drug, and the bulk drug includes gingko benevolence, PERICARPIUM TRICHOSANTHIS, the tuber of dwarf lilyturf, matrimony vine, black soya bean, caulis bambusae in taenian, Exocarpium Citri Rubrum, semen armeniacae amarae, perilla leaf, the fruit of Chinese magnoliavine, Chinese ephedra, flat shellfish, betel nut, Fructus Mume, the root of purple-flowered peucedanum, rhizoma pinellinae praeparata, pollen pini, the wind-weed, gypsum, terminalia flesh, Longstamen Onion Bulb, asarum, blackberry lily, honey-fried licorice root；The perilla leaf of the parts by weight, semen armeniacae amarae, gingko benevolence, black soya bean are put into interior extraction filtrate in extractor；Filtrate is concentrated and receives cream, and uses microwave dryer by extract dry；Rest materials, by sterilizing, drying, with middle dry cream after mixing, are crushed using micronizer by component, medicinal powder are mixed to prepare into medicine activity component；Medicine activity component is made to required formulation according to a conventional method.Each bulk drug in prescription of the present invention complements each other, the effect of strengthening medicine, reduces adverse reaction, reach radical cure asthma this.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of medicine for treating asthma, the invention further relates to the medicine
Preparation method.
Background technology
Asthma is respiratory tract common disease, can betide any age, but the onset more than half before 12 years old, and be grown up men and women
The incidence of disease is substantially similar.The people of whole world bronchial astehma person about 100,000,000, bronchial astehma is a kind of common disease, frequently-occurring disease, by a variety of
Cell（Such as eosinophil, mast cell, T cell, human airway epithelial cells）The air flue chronic inflammation participated in cellular component
Disease property disease, is counted according to WHO, and global asthmatic patient number has more than 180,000 people die from asthma every year up to 2.75 hundred million people.Nearly 10 years
Come, the morbidity and mortality of asthma persistently rise.The asthma prevalence in China be 1% ~ 4%, child morbidity rate be 2%, asthma into
For the major chronic illnesses of serious threat health of people, treatment not in time, it is lack of standardization, asthma may be fatal.
Anti-asthmatic medicament is broadly divided into two major classes at present：One kind is anti-inflammatory drug, including glucocorticoid, health leukotriene medicine
Thing and inflammatory mediator sustained-release agent；Another kind of is bronchodilators, including β2- receptor stimulating agent, anticholinergic agents and theophylline
Class medicine.The therapeutic modality of above doctor trained in Western medicine makes remission, is not treated for asthma reason so that asthma
Feelings recurrent exerbation, and dependence is produced to medicine, the normal life of asthmatic patient is influenceed, simultaneously as Western medicine side effect is big, in addition
Asthma patient can not carry out strenuous exercise, can not take exercises, and eventually cause other health problems.
The content of the invention
For the above situation, the technical problems to be solved by the invention are to provide a kind of medicine for treating asthma, each raw material
Medicine complements each other, the effect of strengthening medicine, reduces adverse reaction, reach radical cure asthma this.
The medicine of the treatment asthma of the present invention, obtained by the medicine preparation of following parts by weight：
The tuber of dwarf lilyturf 15 ~ 30 of 35 ~ 50 PERICARPIUM TRICHOSANTHIS of gingko benevolence 15 ~ 30
The caulis bambusae in taenian 15 ~ 20 of 15 ~ 30 black soya bean of matrimony vine 15 ~ 30
The perilla leaf 5 ~ 15 of 15 ~ 30 semen armeniacae amarae of Exocarpium Citri Rubrum 15 ~ 20
5 ~ 15 Chinese ephedra of the fruit of Chinese magnoliavine, 5 ~ 15 flat shellfish 5 ~ 15
The root of purple-flowered peucedanum 5 ~ 15 of 5 ~ 15 Fructus Mume of betel nut 5 ~ 15
The wind-weed 15 ~ 20 of 15 ~ 20 pollen pini of rhizoma pinellinae praeparata 15 ~ 20
The Longstamen Onion Bulb 15 ~ 20 of 15 ~ 25 terminalia flesh of gypsum 15 ~ 20
The honey-fried licorice root 5 ~ 10 of 5 ~ 10 blackberry lily of asarum 5 ~ 10.
Preferably, medicine of the invention is obtained by the medicine preparation of following parts by weight：
The tuber of dwarf lilyturf 30 of 50 PERICARPIUM TRICHOSANTHIS of gingko benevolence 30
The caulis bambusae in taenian 20 of 30 black soya bean of matrimony vine 30
The perilla leaf 15 of 30 semen armeniacae amarae of Exocarpium Citri Rubrum 20
5 Chinese ephedra of the fruit of Chinese magnoliavine, 15 flat shellfish 15
The root of purple-flowered peucedanum 15 of 15 Fructus Mume of betel nut 15
The wind-weed 20 of 20 pollen pini of rhizoma pinellinae praeparata 20
The Longstamen Onion Bulb 20 of 24 terminalia flesh of gypsum 20
The honey-fried licorice root 9 of 9 blackberry lily of asarum 9.
The preparation method of medicine of the present invention is as follows：
（1）In the perilla leaf of the parts by weight, semen armeniacae amarae, gingko benevolence, black soya bean are put into extractor, add water to and flood medicinal material
Decocted after immersion 0.5h, collect filtrate；
（2）Filtrate is concentrated and receives cream, and uses microwave dryer by extract dry；
（3）Rest materials by component by sterilizing, dry, after mixing with（2）Middle dry cream, is crushed using micronizer,
So that medicinal powder medium particle diameter reaches 5 ~ below 10um, medicinal powder is mixed to prepare medicine activity component；
（4）Medicine activity component is made to required formulation according to a conventional method.
Various peroral dosage forms, such as pulvis, tablet, capsule, honeyed bolus can be made in the active component of medicine of the present invention, this
Excellent pill is invented, adding, which can make active component be mixed into the honey of ball, is made pill.
It is further preferred that the Extracting temperature of extractor is described in the preparation method step of the medicine of the treatment asthma
80-90 DEG C, 60-70 DEG C of the drying temperature of the microwave dryer, the time is 80-90 minutes, the work of the micronizer
40-50 DEG C of temperature.
The preparation method of the present invention has advantages below：
（1）Micronizer uses supersonic jet mill, entirely different with conventional purely mechanic breaking method, in crushing process
In will not produce hot-spot phenomenon, or even can be crushed under low-temperature condition, speed is fast, and moment can complete, thus most
Retain to limits the bioactive ingredients of powder, in favor of required high quality medicine is made.
（2）Because using supersonic jet mill, its distribution of power on raw material is quite uniform, the setting of hierarchy system,
Both bulky grain is strictly limited, avoided the occurrence of broken, obtains the uniform superfine powder of particle diameter distribution, while largely increase
The specific surface area of micro mist, make the also corresponding increase such as adsorptivity, dissolubility.
（3）Ultramicro grinding is carried out under closed system, has both been avoided micro mist pollution surrounding environment, can have been prevented again in air
Dust polluted product, therefore use the technology, content of microorganisms and dust are just controlled.
Gingko benevolence astringing lung for relieving asthma in inventive formulation；PERICARPIUM TRICHOSANTHIS clearing heat and eliminating phlegm, the sharp wide chest of gas；Tuber of dwarf lilyturf nourishing Yin and promoting production of body fluid, moistening lung
Clear away heart-fire；Matrimony vine is nourishing liver and kidney, benefiting shrewd head；Black soya bean benefiting shrewd head, nourishing the blood to expel wind, Li Shui, removing toxic substances；Caulis bambusae in taenian clearing heat and eliminating phlegm, relieving restlessness,
Preventing or arresting vomiting；Exocarpium Citri Rubrum regulating the flow of QI to ease the stomach is eliminating dampness and eliminating phlegm；Semen armeniacae amarae sending down abnormally ascending is relieving cough and asthma；Perilla leaf relieving exterior syndrome and dispelling cold, relieving QI stagnancy in the stomach；The fruit of Chinese magnoliavine
Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney calming；Chinese ephedra sweating cold dispelling, freeings lung and relieving asthma, inducing diuresis for removing edema；Flat shellfish clearing heat and moistening lung, resolving sputum stop
Cough；Betel nut desinsection, disperse accumulations, promoting the circulation of qi, Li Shui；Fructus Mume is astringed the lung, and puckery intestines, is promoted the production of body fluid；Root of purple-flowered peucedanum lowering the adverse-rising QI to resolve phlegm, dissipate wind heat-clearing；Rhizoma pinellinae praeparata
It is eliminating dampness and eliminating phlegm；Pollen pini astringing to arrest bleeding, eliminating dampness and astringing sores；Wind-weed clearing heat-fire, nourishing Yin and moistening dryness；Gypsum clearing heat-fire, relieving restlessness stop
Yearningly；Terminalia flesh is astringed the lung, puckery intestines, lower gas；Longstamen Onion Bulb activates yang and remove abstruction, and promoting the circulation of qi is led stagnant；Asarum relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, temperature
Lungization is drunk；Blackberry lily is clearing heat and detoxicating, eliminating the phlegm, relieving sore-throat；Honey-fried licorice root tonifying spleen and stomach, Yiqi and vein recovery；Monarch drug in a prescription gingko benevolence, PERICARPIUM TRICHOSANTHIS, bitter apricot
Benevolence, caulis bambusae in taenian, typhoid cough is treated, is freeinged lung and relieving asthma, preventing phlegm from forming and stopping coughing；It is the ministerial drug tuber of dwarf lilyturf, Exocarpium Citri Rubrum, perilla leaf, Chinese ephedra, Longstamen Onion Bulb, blackberry lily, flat
Shellfish, asarum, the wind-weed, the root of purple-flowered peucedanum promote the production of body fluid to quench thirst, and rescue cloudy to moisturize, auxiliary monarch drug in a prescription, remove cold air, reason lung qi；The adjutant fruit of Chinese magnoliavine, matrimony vine
Son, terminalia flesh, rhizoma pinellinae praeparata, black soya bean, Fructus Mume, betel nut, the strong medicines such as Chinese ephedra, the fruit of Chinese magnoliavine, fruit of Chinese wolfberry etc. being eliminated, convergence is astringent or styptic treatment for spontaneous sweating,
Nourishing generate fluid；The adjutant fruit of Chinese magnoliavine, the fruit of Chinese wolfberry, terminalia flesh, rhizoma pinellinae praeparata, black soya bean, Fructus Mume, betel nut；Make medicine honey-fried licorice root coordinating the drug actions of a prescription,
Eliminating evil with joint efforts；By compatibility, each component complements each other, the effect of strengthening medicine, reduces adverse reaction, reach radical cure asthma it
This.
Security clinically has been carried out to treatment asthma using pill made from medicine activity component of the present invention and curative effect is seen
Examine：
1st, patient profiles
The asthmatic patient 165 that hospital makes a definite diagnosis is selected, patient symptom is：During seizure of disease with cough, expectoration, pant, breathe it is tired
The symptoms such as difficult, uncomfortable in chest and pectoralgia.Wherein, male 93, women 72, patient's average age are 43.3 ± 2.4 years old.
2nd, treatment method
The pill of the oral embodiment of the present invention 1 of case patient is included, three times a day, 2 tablets each time.
3rd, curative effect determinate standard：
Cure：Asthma control, wheezing sound disappear；
Take a turn for the better：Stable asthma, or attack times are reduced；
It is not cured：Symptom is unchanged.
4th, treatment results
In 165 patients, clinical cure 102, cure rate 61.9%, take a turn for the better 55, obvious effective rate 33.3%, total improvement rate 95.2%,
Invalid 8, inefficiency 4.8%.
Embodiment
Embodiment 1
Take gingko benevolence 50g, the g of PERICARPIUM TRICHOSANTHIS 30, the g of the tuber of dwarf lilyturf 30, the g of matrimony vine 30, the g of black soya bean 30, the g of caulis bambusae in taenian 20, the g of Exocarpium Citri Rubrum 30, bitter apricot
Benevolence 20g, the g of perilla leaf 15, the g of the fruit of Chinese magnoliavine 5, the g of Chinese ephedra 15, the g of flat shellfish 15, the g of betel nut 15, the g of Fructus Mume 15, the g of the root of purple-flowered peucedanum 15, method
The g of the tuber of pinellia 20, the g of pollen pini 20, the g of the wind-weed 20, gypsum 25g, the g of terminalia flesh 20, the g of Longstamen Onion Bulb 20, the g of asarum 9, the g of blackberry lily 9, process
The g of radix glycyrrhizae 9；
（1）In the perilla leaf of above-mentioned parts by weight, semen armeniacae amarae, gingko benevolence, black soya bean are put into extractor, the extractor is lake
The extractor of the HDWN-1000/3500 series of Nan Ruijian productions, add water to after flooding medicinal material immersion 0.5h and decocted, collected
Filtrate；
（2）Filtrate is concentrated and receives cream, the ZWXJ-400-1500 high-efficient energy-saving alcohols that cream uses the auspicious strong production in Hunan are received in filtrate concentration
Recover carries out concentration and receives cream, and using microwave dryer by extract dry, the microwave dryer is the circle production of day wawter bloom
The box micro-wave vacuum casees of HWZ-30B III；
（3）Rest materials by component by sterilizing, dry, after mixing with（2）Middle dry cream, is crushed using micronizer,
So that medicinal powder medium particle diameter reaches 5 ~ below 10um, medicinal powder is mixed to prepare medicine activity component；
（4）Medicine activity component, which is added, which can make active component be mixed into the honey of ball, is made pill.
Embodiment 2
Take gingko benevolence 35g, PERICARPIUM TRICHOSANTHIS 15g, the g of the tuber of dwarf lilyturf 15, matrimony vine 15g, the g of black soya bean 15, the g of caulis bambusae in taenian 15, Exocarpium Citri Rubrum 15g, semen armeniacae amarae
15g, the g of perilla leaf 5, the g of the fruit of Chinese magnoliavine 5, the g of Chinese ephedra 5, the g of flat shellfish 5, the g of betel nut 5, the g of Fructus Mume 5, the g of the root of purple-flowered peucedanum 5, the g of rhizoma pinellinae praeparata 15,
The g of pollen pini 15, the g of the wind-weed 15, gypsum 15g, the g of terminalia flesh 15, the g of Longstamen Onion Bulb 15, the g of asarum 5, the g of blackberry lily 5, the g of honey-fried licorice root 5；
（1）In the perilla leaf of above-mentioned parts by weight, semen armeniacae amarae, gingko benevolence, black soya bean are put into extractor, the extractor is lake
The extractor of the HDWN-1000/3500 series of Nan Ruijian productions, add water to after flooding medicinal material immersion 0.5h and decocted, collected
Filtrate；
（2）Filtrate is concentrated and receives cream, the ZWXJ-400-1500 high-efficient energy-saving alcohols that cream uses the auspicious strong production in Hunan are received in filtrate concentration
Recover carries out concentration and receives cream, and using microwave dryer by extract dry, the microwave dryer is the circle production of day wawter bloom
The box micro-wave vacuum casees of HWZ-30B III；
（3）Rest materials by component by sterilizing, dry, after mixing with（2）Middle dry cream, is crushed using micronizer,
So that medicinal powder medium particle diameter reaches 5 ~ below 10um, medicinal powder is mixed to prepare medicine activity component；
（4）Medicine activity component, which is added, which can make active component be mixed into the honey of ball, is made pill.
Embodiment 3
Take gingko benevolence 40g, PERICARPIUM TRICHOSANTHIS 20g, the g of the tuber of dwarf lilyturf 25, matrimony vine 25g, the g of black soya bean 20, the g of caulis bambusae in taenian 18, Exocarpium Citri Rubrum 18g, semen armeniacae amarae
18g, the g of perilla leaf 10, fruit of Chinese magnoliavine 10g, Chinese ephedra 10g, the g of flat shellfish 10, betel nut 10g, Fructus Mume 10g, the g of the root of purple-flowered peucedanum 10, rhizoma pinellinae praeparata
18g, the g of pollen pini 18, the g of the wind-weed 18, gypsum 20g, terminalia flesh 18g, the g of Longstamen Onion Bulb 18, the g of asarum 8, the g of blackberry lily 8, honey-fried licorice root 8
g；
（1）In the perilla leaf of above-mentioned parts by weight, semen armeniacae amarae, gingko benevolence, black soya bean are put into extractor, the extractor is lake
The extractor of the HDWN-1000/3500 series of Nan Ruijian productions, add water to after flooding medicinal material immersion 0.5h and decocted, collected
Filtrate；
（2）Filtrate is concentrated and receives cream, the ZWXJ-400-1500 high-efficient energy-saving alcohols that cream uses the auspicious strong production in Hunan are received in filtrate concentration
Recover carries out concentration and receives cream, and using microwave dryer by extract dry, the microwave dryer is the circle production of day wawter bloom
The box micro-wave vacuum casees of HWZ-30B III；
（3）Rest materials by component by sterilizing, dry, after mixing with（2）Middle dry cream, is crushed using micronizer,
So that medicinal powder medium particle diameter reaches 5 ~ below 10um, medicinal powder is mixed to prepare medicine activity component；
（4）Medicine activity component, which is added, which can make active component be mixed into the honey of ball, is made pill.
Claims (8)
1. a kind of medicine for treating asthma, it is characterised in that obtained by the medicine preparation of following parts by weight：
The tuber of dwarf lilyturf 15 ~ 30 of 35 ~ 50 PERICARPIUM TRICHOSANTHIS of gingko benevolence 15 ~ 30
The caulis bambusae in taenian 15 ~ 20 of 15 ~ 30 black soya bean of matrimony vine 15 ~ 30
The perilla leaf 5 ~ 15 of 15 ~ 20 semen armeniacae amarae of Exocarpium Citri Rubrum 15 ~ 20
5 ~ 1 Chinese ephedra of the fruit of Chinese magnoliavine, 15 ~ 15 flat shellfish 5 ~ 15
The root of purple-flowered peucedanum 5 ~ 15 of 5 ~ 15 Fructus Mume of betel nut 5 ~ 15
The wind-weed 15 ~ 20 of 15 ~ 20 pollen pini of rhizoma pinellinae praeparata 15 ~ 20
The Longstamen Onion Bulb 15 ~ 20 of 15 ~ 25 terminalia flesh of gypsum 15 ~ 20
The honey-fried licorice root 5 ~ 10 of 5 ~ 10 blackberry lily of asarum 5 ~ 10.
2. the medicine for the treatment of asthma according to claim 1, it is characterised in that obtained by the medicine preparation of following parts by weight
：
The tuber of dwarf lilyturf 30 of 50 PERICARPIUM TRICHOSANTHIS of gingko benevolence 30
The caulis bambusae in taenian 20 of 30 black soya bean of matrimony vine 30
The perilla leaf 15 of 30 semen armeniacae amarae of Exocarpium Citri Rubrum 20
5 Chinese ephedra of the fruit of Chinese magnoliavine, 15 flat shellfish 15
The root of purple-flowered peucedanum 15 of 15 Fructus Mume of betel nut 15
The wind-weed 20 of 20 pollen pini of rhizoma pinellinae praeparata 20
The Longstamen Onion Bulb 20 of 24 terminalia flesh of gypsum 20
The honey-fried licorice root 9 of 9 blackberry lily of asarum 9.
3. treatment asthma according to claim 1 or 2, it is characterised in that the medicine is peroral dosage form.
4. the medicine for the treatment of asthma according to claim 3, it is characterised in that the peroral dosage form of the medicine is pill.
5. the preparation method of the medicine of the treatment asthma of claim 1 or 2, it is characterised in that comprise the following steps：
（1）Each medicine is weighed according to the pharmaceutical formulation, the perilla leaf weighed, semen armeniacae amarae, gingko benevolence, black soya bean are put into extractor
It is interior, add water to after flooding medicinal material immersion 0.5h and carry out decoction 0.5h, collect filtrate；
（2）Filtrate is concentrated and receives cream, using microwave dryer by extract dry；
（3）Rest materials by component by sterilizing, dry, after mixing with step（2）In dry cream, carried out using micronizer
Crush so that medicinal powder particle diameter reaches 5 ~ below 10um, medicinal powder is well mixed standby；
（4）Above-mentioned medicinal powder is made to required formulation according to a conventional method.
6. the preparation method for the treatment of asthmatic medicament according to claim 5, it is characterised in that the extraction temperature of the extractor
Spend for 80-90 DEG C.
7. the preparation method for the treatment of asthmatic medicament according to claim 5, it is characterised in that the microwave dryer is done
Dry temperature is 60-70 DEG C, and drying time is 80-90 minutes.
8. the preparation method for the treatment of asthmatic medicament according to claim 5, it is characterised in that the work of the micronizer
Make temperature as 40-50 DEG C.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553595A (en) * | 2018-07-04 | 2018-09-21 | 江西国药有限责任公司 | Asthma pill and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173640A (en) * | 2013-05-28 | 2014-12-03 | 天津鸿海科技开发有限责任公司 | Treatment formula for phlegm and retained fluid dyspnea with cough |
| CN106075163A (en) * | 2016-08-16 | 2016-11-09 | 安徽天乾健食品科技有限公司 | One treats bronchial asthma in acute attack Chinese prescription and preparation method thereof |
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2017
- 2017-10-26 CN CN201711015390.XA patent/CN107596175A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104173640A (en) * | 2013-05-28 | 2014-12-03 | 天津鸿海科技开发有限责任公司 | Treatment formula for phlegm and retained fluid dyspnea with cough |
| CN106075163A (en) * | 2016-08-16 | 2016-11-09 | 安徽天乾健食品科技有限公司 | One treats bronchial asthma in acute attack Chinese prescription and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553595A (en) * | 2018-07-04 | 2018-09-21 | 江西国药有限责任公司 | Asthma pill and preparation method thereof |
| CN108553595B (en) * | 2018-07-04 | 2021-03-05 | 江西国药有限责任公司 | Asthma pill and preparation method thereof |
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Application publication date: 20180119 |