CN107596063A - A kind of Chinese medicine composition for treating renal anemia - Google Patents

Abstract

The invention discloses a kind of Chinese medicine composition for treating renal anemia, and 10 30 parts of Chinese yam, 10 30 parts of matrimony vine is made by the medicine of following parts by weight, 10 30 parts of the bark of eucommia, 10 20 parts of radix cyathulae, 10 30 parts of Radix Codonopsis, 10 30 parts of eclipta, 5 20 parts of Radix Angelicae Sinensis, 5 20 parts of peach kernel, 5 20 parts of safflower, 5 20 parts of Ligusticum wallichii, 10 30 parts of cultivated land, 10 40 parts of the fleece-flower root, 10 30 parts of motherwort, 5 20 parts of radix glycyrrhizae, according to certain compatibility requirement, by being processed into.

Description

A kind of Chinese medicine composition for treating renal anemia

Technical field

The invention belongs to technical field of traditional Chinese medicines, more particularly, to a kind of Chinese medicine composition for treating renal anemia.

Background technology

CKD (Chronic kidney disease, CKD) is common clinical, frequently-occurring disease, at present into For global public health problem.China's adult large sample investigation in 2012 shows that CKD illness rates are about 10.8%, National CKD patient is about 1.195 hundred million, and white elephant is caused to patient individual, family and society.Renal anemia（Renal Anemia, RA）It is one of most common complication of CKD, and influences the important risk factor of CKD patient's prognosis, haemodialysis It is more common in (Hemodialysis, HD) patient.RA is to cause CKD progress, cardiovascular complication, the weight for increasing the death rate Hazards are wanted, most CKD patient's early stages may occur in which anaemia, as decreased renal function anaemia incidence constantly raises.RA's Diagnosis and treatment are the hot issues of current vast medical matters researcher concern.RA correction is to evaluate the weight of its life span and life quality Index is wanted, and the compliance rate of the treatment rate of current China CKD anemias and hemoglobin (Hemoglobin, Hb) is still very It is low, the diagnosis and treatment of CKD anemias how are improved, increase Hb compliance rate, are still RA treatment facing challenges.Although have proven to Hematopoietin（Erythropoietin, EPO）And the like replacement therapy, it is curative for effect, but because by its payment for medical care Influenceed with, factors such as dosage individual difference, hypoergia；And hypertension, epilepsy, embolism, iatrogenic PRCA be present Deng adverse reaction, it is difficult to obtain good risk/benefit.In a word, the current treatment of doctor trained in Western medicine has significant limitation.

The content of the invention

It is an object of the invention to provide a kind of curative for effect, few side effects, reduce endotoxin level, improve nutritional status, Kidney is protected, shortens Hb reaching standard times, improves clinical symptoms, life quality is improved, delays in the treatment of disease progression-severe kidney The Chinese medicine composition of property anaemia.

The object of the present invention is achieved like this, according to traditional Chinese medical theory, using the unique property of medicine of Chinese medicine,

A kind of Chinese medicine composition for treating renal anemia, Chinese yam 10-30 parts, matrimony vine 10-30 are made by the medicine of following parts by weight Part, bark of eucommia 10-30 parts, radix cyathulae 10-20 parts, Radix Codonopsis 10-30 parts, eclipta 10-30 parts, Radix Angelicae Sinensis 5-20 parts, peach kernel 5-20 parts, Safflower 5-20 parts, Ligusticum wallichii 5-20 parts, cultivated land 10-30 parts, fleece-flower root 10-40 parts, motherwort 10-30 parts, radix glycyrrhizae 5-20 parts, according to Certain compatibility requirement, by being processed into.

Chinese medicine composition of the present invention is prepared to be made up of following raw material medicaments：

Chinese yam 10-30 parts, matrimony vine 10-30 parts, bark of eucommia 10-30 parts, radix cyathulae 10-20 parts, Radix Codonopsis 10-30 parts, eclipta 10- 30 parts, Radix Angelicae Sinensis 5-20 parts, peach kernel 5-20 parts, safflower 5-20 parts, Ligusticum wallichii 5-20 parts, cultivated land 10-30 parts, fleece-flower root 10-30 parts, benefit Brittle Falsepimpernel Herb 10-30 parts, radix glycyrrhizae 5-20 parts

Optimum weight part of traditional Chinese medicinal composition raw materials of the present invention is：20 parts of Chinese yam, 15 parts of matrimony vine, 15 parts of the bark of eucommia, radix cyathulae 15 Part, 15 parts of Radix Codonopsis, 15 parts of eclipta, 10 parts of Radix Angelicae Sinensis, 12 parts of peach kernel, 10 parts of safflower, 12 parts of Ligusticum wallichii, 15 parts of cultivated land, the fleece-flower root 20 Part, 20 parts of motherwort, 8 parts of radix glycyrrhizae.

The pharmacological action of Chinese medicine of the present invention is as follows：

Chinese yam：It is sweet, flat；Return lung, spleen, kidney channel.Tonifying spleen；Support lung；Reinforce the kidney；Strengthening the essence.For splenasthenic diarrhea, deficiency of food edema, deficiency syndrome of the lung cough Asthma, is quenched one's thirst, and passes out semen, and under band, carbuncle swells, scrofula etc. are controlled in kidney deficiency frequent micturition, external application.

Matrimony vine：It is sweet, flat；Return liver and kidney channel.Nourshing kidney, moistening lung, tonifying liver, improving eyesight.Liver-kidney Yin deficiency is cured mainly, soreness and weakness of waist and knees is dizzy, It is dizzy, the more tears of blurred vision, cough due to consumptive disease, quench one's thirst, seminal emission etc..

The bark of eucommia：It is sweet, warm.Return liver and kidney channel.Nourishing liver and kidney, astringent sperm contracting urine is antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, urine There are the heeltap, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, spleen kidney deficiency to rush down；Externally treating leucoderma etc..

Radix cyathulae：Sweet, slight bitter, put down.Return liver and kidney channel.Invigorate blood circulation, dispelling wind and eliminating dampness is easing joint movement, the work(of inducing diuresis for treating strangurtia Effect, cure mainly blood stasis, dysmenorrhoea, difficult labour, placenta retension, joint pain, sufficient impotence muscle contraction, hematuria, blood strangury, injury from falling down etc..

Radix Codonopsis：It is sweet, flat.Returns spleen, lung channel.QI invigorating, promote the production of body fluid, blood-nourishing.For the physically weak burnout of the deficiency of qi in middle-jiao, lung qi virtual loss Cough shortness of breath, the shortness of breath that gas Tianjin two is hindered is thirsty, dizzy palpitaition etc..

Eclipta：It is sweet, sour, tremble with fear.Channel tropism：Return kidney, Liver Channel.Major function：It is nourishing liver and kidney, cooling blood and hemostasis.For tooth pine It is dynamic, poliosis, dizziness and tinnitus, soreness and weakness of waist and knees, YinXuXueRe, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, metrostaxis, traumatism and bleeding Deng.

Radix Angelicae Sinensis：It is sweet, pungent, warm, Return liver, the heart, the spleen channel.Enrich blood, invigorate blood circulation, menstruation regulating, analgesic.For heart-liver blood deficiency, ulcer sores.

Peach kernel：Acrid, bitter, warm.Returns spleen, stomach, liver, lung channel.Promoting qi circulation and relieving pain, lead in tune stagnant.Fullness in chest and hypochondrium is cured mainly, gastral cavity abdomen is swollen Bitterly, vomiting and diarrhea etc..

Safflower：It is pungent, warm.The thoughts of returning home, Liver Channel.Invigorate blood circulation, stasis-dispelling and pain-killing.Cure mainly blood stasis, chest impediment and cardialgia , Disorder lumps in the abdomen product It is poly-, arthralgia etc..

Ligusticum wallichii：It is pungent, warm.Return liver, courage, the heart channel of Hang-Shaoyin.Blood-activating and qi-promoting, wind-expelling pain-stopping.For stagnation of QI and blood, arthralgia pain due to rheumatism.

Cultivated land：Acrid, bitter, warm, returns spleen, stomach, lung channel.During qi-regulating is adjusted, stopping nausea and vomiting by lowering the adverse flow of QI is eliminating dampness and eliminating phlegm.For full vexed, the gastral cavity of chest diaphragm Abdominal distention and pain, do not feel like eating, vomiting etc..

The fleece-flower root：Bitter, sweet, colour temperature.Return liver, kidney channel.Filling liver kidney, benefiting essence-blood, black beard and hair, strengthening the bones and muscles, relax bowel, blood-nourishing Calm the nerves, brain swoon tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, neurasthenia, hyperlipemia.

Motherwort：It is arduous, cool in nature.Invigorate blood circulation, silt of dispelling, menstruation regulating, disappear water the effect of.Menoxenia is treated, threatened abortion is had difficult labour, Placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rush down blood, carbuncle swells sore.

Radix glycyrrhizae：It is sweet, flat, the thoughts of returning home, lung, spleen, stomach.Invigorating middle warmer and replenishing QI, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, harmonizing drug Property.Severe palpilation, intermittent pulse for deficiency of heart-QI, pathopyretic ulcer, abscess of throat.

Renal anemia is mainly because endogenous EPO hyposecretions and toxin are different to medulla hematopoietic system suppression, erythrocyte metabolism Often, the multifactor correlation such as hematopoiesis insufficient raw material, micro milling.Motherland's medical science is belonged to according to its cause of disease, the interpretation of the cause, onset and process of an illness and clinical manifestation In categories such as the traditional Chinese medical science " consumptive disease, oedema, the deficiency of blood ".Traditional Chinese medicine thinks this empty table actually its interpretation of the cause, onset and process of an illness, and this void is declined with spleen kidney deficiency, qi and blood life Change weary source, kidney essense bone is weary, and essence and blood is unable to alternate, causes deficiency in both Qi and blood；Mark is real to be lost with internal organs void, wet turbid what resistance, mixture of asthenia and sthenia, mutually For cause and effect, vicious circle.Treatment is with kidney and spleen invigorating qi and activate blood circulation, and taking into account is turbid to let out silt, and macroscopic view is dialectical to be treated, and giving consideration to both the incidental and fundamental, is attacked Mend it is simultaneous apply, actual situation is gone forward side by side, and qi and blood is laid equal stress on, Yin Shiyin people and preferably principle.Chinese yam, matrimony vine, bark of eucommia nourishing kidney qi, controlling nocturnal emission with astringent drugs are filled out in side Marrow, the source with nourishing liter blood；Radix Angelicae Sinensis, peach kernel, safflower, rhizome of chuanxiong, cultivated land add the promoting blood circulations such as eclipta, Radix Angelicae Sinensis, radix cyathulae, motherwort to mend Blood dredging collateral, stasis eliminatings life are new, QI invigorating dampness elimination, blood-nourishing rising Yang, strong fortune kidney spleen, solid table benefit are defended, nourish cloudy kidney, inducing diuresis for treating strangurtia；Radix glycyrrhizae and Middle emergency, coordinating the drug actions of a prescription.

From in January, 2015-2016 year January the chronic renal insufficiency that our hospital is in hospital with-patient of anemia 75, male 39, female 36.It is randomly divided into treatment group（38）With control group（37）.Two groups of patient ages, sex, the course of disease, The cause of disease, severity of anemia, renal function situation, there was no significant difference (P>0.05), there is comparativity.All patients give renal diet, Blood pressure is controlled, maintains the complex treatment such as Water-Electrolyte acid-base balance, chalybeate, folic acid and vitamin B12.Control group gives rHuEPO （Sansheng pharmacy Co., Ltd., Shenyang city）It is subcutaneously injected, dosage is 80-120 u/ (Kg weeks), point 2 injections, continuous 8 weeks. Treatment group 38 gives traditional Chinese medicine for oral administration on the basis of control group.Chinese medicine composition of the present invention was in clinical observation in 2015 to 2016 In -38 patients of severe renal anemia, clinical report is as follows：

1st, general information

The chronic renal insufficiency that our hospital is in hospital with-patient 39 of anemia, male 21, female 18, the age 18~74 It is year, average（45.68±11.39）Year old, chronic nephritis 12 in its protopathy, diabetic nephropathy 10, hypertensive renal damage 8 Example, IgA nephrosis 5, HSPN 2, chronic pyelonephritis 1, drug-induced renal impairment 1.

2nd, case is selected, exclusion standard：

Inclusion criteria：Chronic renal failure Decompensated stage with anaemia nondialytic treatment patient, by American National in 2002 " guidance of kidney trouble life quality " of kidney trouble foundation（K/DOQI）By stages up to 3-5 phases, GFR<60ml/min/1.73m², Scr is higher than normal, Hb≤90g/L, Hct≤30%.Exclusion standard：Used rHuEPO and traditional Chinese herbal decoction or treatment nephrosis in January Chinese patent drug person；There is blood transfusion history person in 2 weeks；Exist and acute and chronic lose blood or receive hormone, cell toxicant or other influence red blood cells Drug therapy person（Chalybeate, folic acid and vitamin B₁₂Except）；Refractory hypertension person；Severe malnutrition, Water-Electrolyte soda acid Balance disorders person；There are bleeding and obvious hemorrhagic tendency person；In the presence of serious cardiopulmonary insufficiency, Diabetic Acute complication, tumour, Liver patient；There are acute and chronic infection or autoimmune disease person；Fail to complete the course for the treatment of in therapeutic process or serious adverse reaction occur Person etc..

3rd, treatment method

3.1 prescription：Chinese yam 20g, matrimony vine 15g, bark of eucommia 15g, radix cyathulae 15g, Radix Codonopsis 15g, eclipta 15g, Radix Angelicae Sinensis 10g, peach kernel 12g, safflower 10g, rhizome of chuanxiong 12g, cultivated land 15g, fleece-flower root 20g, motherwort 20g, radix glycyrrhizae 8g.Added and subtracted with disease, 15 doses are 1 course for the treatment of.

3.2 preparation method：Routinely decoction is made in technique to said medicine.

3.3 instructions of taking：1 dose every time, one time a day, 15 days are 1 course for the treatment of, even served 3 courses for the treatment of.

4th, treatment results：

4.1 the standard of curative effect evaluation：

It is effective：During treatment or terminate after, Hb risings >=30g/L and（Or）Hct rises >=0.1, or Hb reaches 100g/L or Hct Up to 0.3, Anemia improves；Effectively：After treatment end Hb risings >=15g/L and（Or）Hct rises >=0.05, and Anemia changes It is kind；It is invalid：These parameters are unchanged or deteriorate.4.2 result：Clinical remission 26 (83.9%), effective 5 (16.1%).

4.2 curative effect comparison therapy groups 39, effective 10, effective 24, invalid 5, total effective rate is 87. 2%.

Integration is (11.79 ± 2.15), (6.12 ± 1.39) before and after treatment for 4.3 Chinese medicine syndrome integrals change treatment group, poor It is different have conspicuousness (P<0.01)。

RBC, Hb, Hct, Ret substantially rise after 4.4 hematological indices comparison therapies, and compared with before treatment, difference has aobvious Work property (P<0. 05).

The hematological indices of table 1 compare (x^—±s)

4. raised after the treatment of 5 iron metabolism Indexes Comparisons before sTfR, SF, TS relatively treatment (P<0.05) ；Difference has conspicuousness (P<0. 05) 。

Iron metabolism Indexes Comparison (the x of table 2^—±s)

BUN, SCr are decreased obviously after the treatment of 4.6 liver kidney function Indexes Comparison treatment groups, and ALB substantially rises, poor compared with before treatment It is different have conspicuousness (P<0.05)。

The liver kidney function Indexes Comparison (x of table 3^—±s)

Embodiment

With reference to embodiment, the present invention is further illustrated, and following embodiments are merely to illustrate of the invention and right The present invention does not limit.

Embodiment 1, a kind of Chinese medicine composition for treating renal anemia, it is by Chinese yam 20g, matrimony vine 15g, bark of eucommia 15g, river ox Knee 12g, Radix Codonopsis 15g, eclipta 15g, Radix Angelicae Sinensis 10g, peach kernel 12g, safflower 10g, rhizome of chuanxiong 12g, cultivated land 15g, fleece-flower root 25g, benefit Brittle Falsepimpernel Herb 20g, radix glycyrrhizae 8g are made.

Embodiment 2, a kind of Chinese medicine composition for treating renal anemia, it is by Chinese yam 20g, matrimony vine 15g, bark of eucommia 15g, river ox Knee 15g, Radix Codonopsis 15g, eclipta 12g, Radix Angelicae Sinensis 10g, peach kernel 15g, safflower 15g, rhizome of chuanxiong 15g, cultivated land 15g, fleece-flower root 20g, benefit Brittle Falsepimpernel Herb 20g, radix glycyrrhizae 9g are made.

Embodiment 3, a kind of Chinese medicine composition for treating renal anemia, it is by Chinese yam 30g, matrimony vine 20g, bark of eucommia 15g, river ox Knee 12g, Radix Codonopsis 20g, eclipta 10g, Radix Angelicae Sinensis 10g, peach kernel 15g, safflower 10g, rhizome of chuanxiong 15g, cultivated land 30g, fleece-flower root 27g, benefit Brittle Falsepimpernel Herb 20g, radix glycyrrhizae 7g are made.

From in January, 2015-2016 year January the chronic renal insufficiency that our hospital is in hospital with-patient of anemia 75, male 39, female 36.It is randomly divided into treatment group（38）With control group（37）.Two groups of patient ages, sex, the course of disease, The cause of disease, severity of anemia, renal function situation, there was no significant difference (P>0.05), there is comparativity.All patients give renal diet, Blood pressure is controlled, maintains the complex treatment such as Water-Electrolyte acid-base balance, chalybeate, folic acid and vitamin B12.Control group gives rHuEPO （Sansheng pharmacy Co., Ltd., Shenyang city）It is subcutaneously injected, dosage is 80-120 u/ (Kg weeks), point 2 injections, continuous 8 weeks. Treatment group 38 gives traditional Chinese medicine for oral administration on the basis of control group.Chinese medicine composition of the present invention was in clinical observation in 2015 to 2016 In -38 patients of severe renal anemia, clinical report is as follows：

1st, general information

The chronic renal insufficiency that our hospital is in hospital with-patient 39 of anemia, male 21, female 18, the age 18~74 It is year, average（45.68±11.39）Year old, chronic nephritis 12 in its protopathy, diabetic nephropathy 10, hypertensive renal damage 8 Example, IgA nephrosis 5, HSPN 2, chronic pyelonephritis 1, drug-induced renal impairment 1.

2nd, case is selected, exclusion standard：

Inclusion criteria：Chronic renal failure Decompensated stage with anaemia nondialytic treatment patient, by American National in 2002 " guidance of kidney trouble life quality " of kidney trouble foundation（K/DOQI）By stages up to 3-5 phases, GFR<60ml/min/1.73m², Scr is higher than normal, Hb≤90g/L, Hct≤30%.Exclusion standard：Used rHuEPO and traditional Chinese herbal decoction or treatment nephrosis in January Chinese patent drug person；There is blood transfusion history person in 2 weeks；Exist and acute and chronic lose blood or receive hormone, cell toxicant or other influence red blood cells Drug therapy person（Chalybeate, folic acid and vitamin B₁₂Except）；Refractory hypertension person；Severe malnutrition, Water-Electrolyte soda acid Balance disorders person；There are bleeding and obvious hemorrhagic tendency person；In the presence of serious cardiopulmonary insufficiency, Diabetic Acute complication, tumour, Liver patient；There are acute and chronic infection or autoimmune disease person；Fail to complete the course for the treatment of in therapeutic process or serious adverse reaction occur Person etc..

3rd, treatment method

3.1 prescription：Chinese yam 20g, matrimony vine 15g, bark of eucommia 15g, radix cyathulae 15g, Radix Codonopsis 15g, eclipta 15g, Radix Angelicae Sinensis 10g, peach kernel 12g, safflower 10g, rhizome of chuanxiong 12g, cultivated land 15g, fleece-flower root 20g, motherwort 20g, radix glycyrrhizae 8g.Added and subtracted with disease, 15 doses are 1 course for the treatment of.

3.2 preparation method：Routinely decoction is made in technique to said medicine.

3.3 instructions of taking：1 dose every time, one time a day, 15 days are 1 course for the treatment of, even served 3 courses for the treatment of.

4th, treatment results：

4.1 the standard of curative effect evaluation：

It is effective：During treatment or terminate after, Hb risings >=30g/L and（Or）Hct rises >=0.1, or Hb reaches 100g/L or Hct Up to 0.3, Anemia improves；Effectively：After treatment end Hb risings >=15g/L and（Or）Hct rises >=0.05, and Anemia changes It is kind；It is invalid：These parameters are unchanged or deteriorate.4.2 result：Clinical remission 26 (83.9%), effective 5 (16.1%).

4.2 curative effect comparison therapy groups 39, effective 10, effective 24, invalid 5, total effective rate is 87. 2%.

Integration is (11.79 ± 2.15), (6.12 ± 1.39) before and after treatment for 4.3 Chinese medicine syndrome integrals change treatment group, poor It is different have conspicuousness (P<0.01)。

RBC, Hb, Hct, Ret substantially rise after 4.4 hematological indices comparison therapies, and compared with before treatment, difference has aobvious Work property (P<0. 05).

The hematological indices of table 1 compare (x^—±s)

4. raised after the treatment of 5 iron metabolism Indexes Comparisons before sTfR, SF, TS relatively treatment (P<0.05) ；Difference has conspicuousness (P<0. 05) 。

Iron metabolism Indexes Comparison (the x of table 2^—±s)

BUN, SCr are decreased obviously after the treatment of 4.6 liver kidney function Indexes Comparison treatment groups, and ALB substantially rises, poor compared with before treatment It is different have conspicuousness (P<0.05)。

The liver kidney function Indexes Comparison (x of table 3^—±s)

Claims (3)

1. A kind of 1. Chinese medicine composition for treating renal anemia, it is characterised in that：Chinese yam 10-30 is made by the medicine of following parts by weight Part, matrimony vine 10-30 parts, bark of eucommia 10-30 parts, radix cyathulae 10-20 parts, Radix Codonopsis 10-30 parts, eclipta 10-30 parts, Radix Angelicae Sinensis 5-20 Part, peach kernel 5-20 parts, safflower 5-20 parts, Ligusticum wallichii 5-20 parts, cultivated land 10-30 parts, fleece-flower root 10-40 parts, motherwort 10-30 parts, Radix glycyrrhizae 5-20 parts.
2. A kind of 2. Chinese medicine composition for treating renal anemia as claimed in claim 1, it is characterised in that：Chinese yam 10-30 parts, matrimony vine 10-30 parts, bark of eucommia 10-30 parts, radix cyathulae 10-20 parts, Radix Codonopsis 10-30 parts, eclipta 10-30 parts, Radix Angelicae Sinensis 5-20 parts, peach kernel 5-20 parts, safflower 5-20 parts, Ligusticum wallichii 5-20 parts, cultivated land 10-30 parts, fleece-flower root 10-30 parts, motherwort 10-30 parts, radix glycyrrhizae 5-20 Part.
3. A kind of 3. Chinese medicine composition for treating renal anemia as claimed in claim 1, it is characterised in that：20 parts of Chinese yam, matrimony vine 15 Part, 15 parts of the bark of eucommia, 15 parts of radix cyathulae, 15 parts of Radix Codonopsis, 15 parts of eclipta, 10 parts of Radix Angelicae Sinensis, 12 parts of peach kernel, 10 parts of safflower, Ligusticum wallichii 12 Part, 15 parts of cultivated land, 20 parts of the fleece-flower root, 20 parts of motherwort, 8 parts of radix glycyrrhizae.