CN107583033B - A kind of eye-care compositions and the phototherapy safety goggles containing the composition - Google Patents
A kind of eye-care compositions and the phototherapy safety goggles containing the composition Download PDFInfo
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Abstract
A kind of phototherapy safety goggles the present invention relates to eye-care compositions and containing the composition, the composition include following component and its parts by weight：10~30 parts of chitosan nano, 10~30 parts of fibroin albumen, 20~30 parts of pearl active peptide, 5~15 parts of L pyrrolidone sodium carboxylates, 10~15 parts of Carbenoxolone Sodium, 40~60 parts of xanthans.The composition can effectively reduce the injury effect of blue light illumination, improve the therapeutic effect to jaundice, coordinate pearl active peptide and fibroin albumen, with preferable moistness, skin defence light aging can be promoted, eye caused by effectivelying prevent long periods of wear eyeshade is dry and astringent, improves the compliance used, and safety is good, and there is no allergy, stimulation phenomenons.It is easy to use in addition, the phototherapy safety goggles containing the eye-care compositions, simple in structure, to the rejection rate of blue light up to more than 99.9%, there is good antibiotic property and gas permeability, be suitble to wear for a long time.
Description
Technical field
The present invention relates to eye health protection the field of medical instrument technology, more particularly to a kind of eye-care compositions and contain
The phototherapy safety goggles of the composition.
Background technology
Jaundice is neonatal period common clinical symptoms, and about 60% newborn may occur in which different degrees of jaundice.It is most of yellow
Subcutaneous ulcer can spontaneous regression, but due to the toxicity of bilirubin, a small number of infants may occur in which severe hyperbilirubinemia, and excessively high bilirubin can
To enter the metabolic function of intracellular interference cell through cell membrane, cause function of brain cell metabolic disorder, newborn is caused
High risks.In due course, effective, safe, economic intervention is carried out to icterus neonatorum, avoids bilirubin encephalopathy, is reduced not
Necessary treatment and medical resource waste are the directions of domestic and international medical field effort for many years.
Blue light illumination is a kind of simplicity, good effect, the quick method for treating icterus neonatorum.Bilirubin can absorb
Light, under the action of light and oxygen, fat-soluble bilirubin is oxidized into a kind of water-soluble product, can be discharged from bile or urine
In vitro, so as to reduce serum unconjugated bilirubin concentration.The absorption band of bilirubin is 400~500 millimicrons, is especially existed
420~440 millimicrons of wavelength time decompositions are most strong, and blue light wavelength is just between 425~475 millimicrons.Blue light is controlled
The treatment principle for the treatment of is exactly by irradiation, and internal bilirubin can be allowed to be converted into other substances so that the courage constantly accumulated in vivo
Red pigment finds another outlet, and the symptom of jaundice can just improve.
Newborn's retina is not developed also completely, particularly sensitive to light.Clinically using blue-light treatment icterus neonatorum disease
Shi Bixu wears eyeshade.However the eyeshade that hospital generally wears when carrying out blue light illumination at present is by the black-out cloth group of one layer of black
Into structure is too simple, and 85% or so is can only achieve for the rejection rate of blue light, however it remains certain eye light damage risk.
In addition, the site of action of phototherapy is mainly the indirect bilirubin in newborn skin superficial tissues gap, deep bilirubin is made
With limited, therefore, clinically treatment icterus neonatorum is carried out using blue light and generally require repeatedly to be spaced treatment, prolong treatment time
It is long, it was differed up to 3~5 days.Meanwhile newborn's eye skin is more fragile compared with being grown up, the thin thin skin skin of eye circumference is very sensitive, crisp
Weak, easily dry, if wearing above-mentioned common eyeshade for a long time, the eye that can cause infant is dry and astringent, its compliance is made to be deteriorated.
Therefore, it is necessary to provide a kind of novel eyeshade, the eyeshade is safe and effective, non-stimulated, in effective block blue light
Meanwhile certain nursing role is played, the compliance of newborn's therapeutic process is improved, and further effectively reduce bilirubin.
Invention content
A kind of phototherapy safety goggles the purpose of the present invention is to provide eye-care compositions and containing the composition, institute
The phototherapy safety goggles stated, with certain nursing role, effectively moisten eyes, make eye while abundant block blue light
The effect of eyeball feels comfortable easily, and can promote reduction bilirubin, raising Icterus treatment, and it is safe and non-stimulating, it is simple in structure,
It is easy to use.
Technical solution provided by the invention is as follows：
A kind of eye-care compositions, including following component and its parts by weight：Chitosan nano 10~30 part, thread
10~30 parts of fibroin, 20~30 parts of pearl active peptide, 5~15 parts of L-Pyrrolidone Carboxylic Acid sodium, 10~15 parts of Carbenoxolone Sodium, Huang
40~60 parts of virgin rubber.
Preferably, the composition includes following component and its parts by weight：25 parts of chitosan nano, fibroin albumen
15 parts, 25 parts of pearl active peptide, 5 parts of L-Pyrrolidone Carboxylic Acid sodium, 15 parts of Carbenoxolone Sodium, 50 parts of xanthans.
Wherein, active components of plants is embedded with inside the chitosan nano, the active components of plants is by accumulating
The careless extract of snow and Rosmarinic acid are with 1:0.05~0.2 mass ratio composition；The active components of plants is in chitosan nano
Content in grain is 0.1~10% (m/m).
Above-mentioned pearl active peptide small molecular activity peptide content is high, molecular weight 100~500Da contents up to 60% with
On, it is to be prepared by specific technique.Specifically he, the preparation process is using high-frequency high-voltage stream process pearl
Fine powder, under the action of electric field force, the organic molecules such as Chitosan-alginate microcapsules are polarized, and show electric polarity, and intermolecular gravitation is destroyed,
Intermolecular distance increases, and malic acid is enable fully to act on inside pearl fine powder, then be passed through what high-frequency high-voltage current was generated by it
Oscillation, makes protein molecular degrade to form small-molecular peptides, compared with conventional enzymatic isolation method, the pearl active peptide content of the invention harvested
Height, solubility property are good.
Further, the preparation of the pearl active peptide includes the following steps：
(1) pearl is taken, is ground to fine powder, using solid-liquid ratio as 1:5 ratios add in the sodium lactate aqueous solution of 60% (m/v), surpass
Sound mixing, adds in malic acid while stirring, until dissolving is complete, make malic acid in system final concentration of 0.1~0.3%,
At room temperature, normal pressure forward current is first passed through into solution, after being passed through the reversed 5~10s of current processing of normal pressure after 10~15s of processing
High-frequency high-voltage current is passed through, cuts off the power after handling 60~90min, obtains treatment fluid；
(2) appropriate glycine buffer, modulation pH to neutrality, Ran Houli are added dropwise into the treatment fluid that step (1) obtains
The heart, collect supernatant, by supernatant be dried under reduced pressure to get.
Normal pressure forward current processing time is passed through in above-mentioned steps (1) as 12s, being passed through the normal pressure reversed current processing time is
6s；The frequency of high-frequency high-voltage current is 6000~9000 hertz, and voltage is 4000~8000 volts.
Further, the preparation of the chitosan nano includes the following steps：
(1) it weighs active components of plants and is dissolved in absolute ethyl alcohol, the ethanol solution of a concentration of 0.01~0.1mg/mL, mistake is made
0.4 μm of filter, it is spare；
(2) chitosan is weighed, is dissolved in 1% acetic acid, the chitosan solution of a concentration of 0.5~2mg/mL is made, is being stirred
Ethanol solution made from lower a dropping step (1), 2~3min of magnetic agitation continuously add tripolyphosphate sodium water solution, and stirring 1~
3min obtains reaction solution；Final concentration of 0.1~0.2% (m/m) of the sodium tripolyphosphate in system.
(3) by reaction solution made from step (2) in 4 DEG C, 10000rpm/min, 2~3min is centrifuged, precipitation is taken, will precipitate
Cleaned 3 times with PBS buffer solution, be dried under reduced pressure to get.
In eye-care compositions provided by the invention, Rosmarinic acid has photoprotection, can further defend indigo plant
Injury of the light to infant's eye, itself and Gotu Kola P.E are applied in combination, and can effectively improve the effect for the treatment of jaundice, simultaneously
The stability of Gotu Kola P.E can also be effectively improved.Further, Rosmarinic acid and Gotu Kola P.E mixture are made
Chitosan nano can reduce the ingredients such as asiatic acid, brahmic acid in Rosmarinic acid and Gotu Kola P.E to baby
The irritation of child's skin improves eye-care compositions safety in utilization.
The pearl active peptide is obtained Chitosan-alginate microcapsules degradation by high-frequency high-voltage stream process for pearl fine powder small
Molecular activity peptide, is used in compounding with fibroin albumen, has preferable repair, mitigates cell oxidative damage caused by blue light illumination
And apoptosis, accelerate cell metabolism, promote the synthesis such as hyaluronic acid, inhibit tyrosinase activity, repaiied so as to reach promotion
It is multiple, the effect of skin-active tender skin.Compared with common Nano pearl powder, pearl active peptide dissolubility of the invention is good, biological utilisation
Degree is high, high with the Miscibility of eye-care compositions of the present invention, long-term to store, and is not in that crystallite is precipitated, more will not be with
Aggregation occurs for chitosan nano.Also, pearl active peptide makes as soluble small-molecular peptides with other compositions compounding
With, uniform system is formed, wears phenomena such as not having foreign body sensation in the process, will not more fall off, it is safe.
In addition, the present invention also provides a kind of preparation method of the eye-care compositions, include the following steps：
(1) xanthans and chitosan nano are weighed, is mixed, suitable quantity of water is added in and is swollen, in a manner of equal increments,
Fibroin albumen, pearl active peptide, L-Pyrrolidone Carboxylic Acid sodium and the Carbenoxolone Sodium dissolved in advance is added under agitation to mix
Liquid is closed, 5~10min of magnetic agitation obtains finished fluid；
(2) finished fluid that (1) obtains is injected into mold under vacuum, it is cured, ultraviolet sterilization is carried out after demoulding, i.e.,
Obtain eye-care compositions.
After testing, eye-care compositions provided by the invention are safe, there is no allergy, stimulation phenomenon, and moisten
Property it is good, skin water loss can be effectively prevent, and with certain photoprotection, be applied to and prepare baby's phototherapy protection
Eyeshade, can effectively defend damage of the blue light illumination to baby, can also avoid long periods of wear safety goggles dry and astringent caused by eyes
Etc. discomforts, improve using compliance.
Baby's phototherapy safety goggles, including：Non-woven fabrics gland band, the left and right two of the non-woven fabrics gland band
Side is provided with the velcro that can mutually paste, and eyeshade ontology is fixed on the bottom end in the middle part of non-woven fabrics gland band, institute by sewing
It states eyeshade ontology and includes the blu-ray reflection film layer, extinction black cloth layer, the nanometer silver antimicrobial spun lacing that are sewed together successively from outside to inside
Nonwoven layer, spongy layer, radiation protection film layer, blue scrim layer and visual function improving film layer；
Further, the visual function improving film layer cover body and ontology composition, the cover body be polyurethane film, the sheet
Body is eye-care compositions produced by the present invention, and the visual function improving film layer passes through for polyurethane film with eye-care compositions
Hot press method is prepared, and the thin polyurethane film thickness is 10~20mm, and the eye-care compositions thickness is
30~50mm.
Further, the eyeshade ontology by two symmetrically and can the eyeshade halfbody of symmetrical fold sew；Institute
State non-woven fabrics immobilizing bandage be located at the top of eyeshade ontology be provided with forehead dew hole；The nanometer silver antimicrobial spunlace non-woven cloth layer
Thickness be 0.2~0.5mm.
Compared with prior art, advantage of the invention is that：
(1) eyeshield composition provided by the invention creatively combines Gotu Kola P.E and Rosmarinic acid with chitosan
The form of nanoparticle uses, and can effectively reduce the injury effect of blue light illumination, improves the therapeutic effect to jaundice, and cooperation pearl lives
Property peptide and fibroin albumen, there is preferable moistness, skin defence light aging can be promoted, long periods of wear eyeshade is effectively prevent to cause
Eye it is dry and astringent, improve the compliance used, and safety is good, there is no allergy, stimulation phenomenon,
(2) phototherapy safety goggles provided by the invention, it is simple in structure, it is easy to use, it is reachable to the rejection rate of blue light
More than 99.9%, and with good antibiotic property and gas permeability, even if wearing for a long time, eye circumference is enclosed tissue play adjusting and
Nursing role is not in the problem of eyes is dry and astringent.
Description of the drawings
Fig. 1：The structure diagram of the present invention.
Fig. 2：The stratiform schematic diagram of eyeshade ontology in the present invention.
The names of the parts and its label are as follows：1st, non-woven fabrics gland band；2nd, eyeshade ontology；21st, blu-ray reflection film layer；
22nd, extinction black cloth layer；23rd, nanometer silver antimicrobial spunlace non-woven cloth layer；24th, spongy layer；25th, radiation protection film layer；26th, blue grid cloth
Layer；27th, visual function improving film layer；3rd, sewing；4th, forehead dew hole；5th, velcro.
Specific embodiment
The preparation of 1 chitosan nano of embodiment
| Group | Chitosan | Active components of plants |
| A groups | 100g | Gotu Kola P.E 4.17g and Rosmarinic acid 0.83g |
| B groups | 100g | Gotu Kola P.E 4.17g |
| C groups | 100g | Baical Skullcap root P.E 4.17g and Rosmarinic acid 0.83g |
The preparation of A groups：
(1) Gotu Kola P.E 4.17g and Rosmarinic acid 0.83g are weighed, is mixed, is dissolved in absolute ethyl alcohol, is made a concentration of
The ethanol solution of 0.1mg/mL crosses 0.4 μm of filter, spare；
(2) chitosan 100g is weighed, is dissolved in 1% acetic acid, the chitosan solution of a concentration of 1mg/mL is made, under stiring
Ethanol solution made from a dropping step (1), magnetic agitation 2min continuously add tripolyphosphate sodium water solution, stir 2min, obtain instead
Answer liquid；
(3) by reaction solution made from step (2) in 4 DEG C, 10000rpm/min, 3min is centrifuged, takes precipitation, precipitation is used
PBS buffer solution clean 3 times, be dried under reduced pressure to get.
The preparation of B groups and C groups refers to A groups.
The preparation of 2 pearl active peptide of embodiment
(1) pearl is taken, is ground to fine powder, using solid-liquid ratio as 1:5 ratios add in the sodium lactate aqueous solution of 60% (m/v), surpass
Sound mixing, adds in malic acid while stirring, until dissolving is complete, make malic acid in system final concentration of 0.2%, in room temperature
Under, normal pressure forward current is first passed through into solution, high-frequency high-voltage is passed through after being passed through the reversed current processing 6s of normal pressure after processing 12s
Stream, the frequency of electric current is 6000 hertz, and voltage is 4000 volts, cuts off the power after handling 60min, obtains treatment fluid；
(2) appropriate glycine buffer, modulation pH to neutrality, Ran Houli are added dropwise into the treatment fluid that step (1) obtains
The heart collects supernatant, supernatant is dried under reduced pressure to get pearl active peptide.
With reference to Chinese patent CN 103333222B " a kind of Pearl natural active peptide and its extraction side with whitening function
Liquid phase chromatogram condition in method and application " is detected pearl active peptide obtained above, pearl active peptide molecule obtained
For amount in 100~500Da contents up to more than 60%, small molecule active peptide content is high.
The preparation of 3 eyeshield composition of embodiment
The composition of 3-4 of the embodiment of the present invention and comparative example 1-4 eyeshield compositions see the table below shown (counting in parts by weight),
Middle pearl active peptide is prepared by embodiment 2.
The preparation of 3 eyeshield composition of embodiment：
(1) xanthans and chitosan nano are weighed, is mixed, suitable quantity of water is added in and is swollen, in a manner of equal increments,
Fibroin albumen, pearl active peptide, L-Pyrrolidone Carboxylic Acid sodium and the Carbenoxolone Sodium dissolved in advance is added under agitation to mix
Liquid is closed, magnetic agitation 5min obtains finished fluid；
(2) finished fluid that (1) obtains is injected into mold under vacuum, it is cured, ultraviolet sterilization is carried out after demoulding, i.e.,
Obtain eye-care compositions.
The preparation reference implementation example 3 of embodiment 4 and comparative example 1-4 eyeshield compositions.
4 safety testing of embodiment
Healthy Hartley cavys 48 (purchased from Guangdong Medical Lab Animal Center) are taken, 270 ± 20g of weight is random to divide
It is 7 groups, every group 10, half male and half female, test group 1-2：Finished fluid made from embodiment 3-4, test group 3-6 are smeared respectively：Point
It Tu Mo not finished fluid, positive controls made from comparative example 1-4：2 are smeared, 4-dinitro-chloro-benzene.According to GB/T16886.10
-2005《BiologicalEvaluationofMedicalDevice》Evaluation is tested and is observed, as a result：The scoring of test group 1-6 is 0, and skin causes
Quick reaction is negative, and safety is good；And there are the symptoms such as erythema in the cavy of positive controls, sensitization of skin reaction is positive.
As it can be seen that eyeshield composition provided by the invention, without sensitization, safety is good.
In addition, 2015 editions issued with reference to the Ministry of Public Health《Cosmetics health specification》In " human skin patch " correlation
It is required that and assay method finished fluid made from 3-4 of the embodiment of the present invention, comparative example 1-4 is tested, respectively 0h, 6h,
12h, for 24 hours, 48h observation dermoreaction, the experimental result of all trial volunteers is negative findings, and it is bad not occur skin
Reaction.Eyeshield composition provided by the invention is nonirritant, and safety is good.
5 moistness effect assessment of embodiment
The BALB/C nude mices 40 of 6 week old are taken, half male and half female is provided by Guangdong Province's animal experimental center.It is randomly divided into 6
Group, every group 10, half male and half female, respectively embodiment 3-4 and comparative example 1-4 groups.Respectively on the right side of each group nude mice skin of back
One side of something smears finished fluid made from embodiment 3-4, comparative example 1-4, and the skin of back of left one side of something then coats physiological saline conduct pair
According to smearing 200 μ l every time, nude mice back skin measured using special skin elasticity (water content) tester after 3 times/day, 6 weeks
The elasticity and water content of skin.The situation restored in a short time according to skin evaluate elasticity size, elasticity number 1 for maximum,
I.e. skin 100% restores to the original state.It the results are shown in Table 1.
Influence of the 1 each test group of table to nude mice skin elasticity and moisture
Note：Compared with the control group,*P ＜ 0.05,**P ＜ 0.01.
As seen from the above table, eyeshield composition moistness is good made from the embodiment of the present invention 2 and 3, can effectively improve skin
Water content makes skin keep preferably elasticity.By comparative example 1 it is found that Rosmarinic acid influences less eyeshield composition moistness；
By comparative example 2 it is found that Baical Skullcap root P.E is applied in combination with Rosmarinic acid, it is applied in combination compared with Gotu Kola P.E and Rosmarinic acid
Moistness is slightly worse, shows that the synergistic effect of both Gotu Kola P.E and Rosmarinic acid is preferable.By comparative example 3 and 4 it is found that with receiving
Rice pearl powder compares, and pearl active peptide is remarkably improved the moistness of eyeshield composition as small-molecular peptides.
6 photoprotection of embodiment is tested
Using HaCaT cells as material, observe eyeshield composition provided by the invention and HaCaT cell survival shadows are irradiated to UVA
It rings, concrete scheme is：
(1) cell of logarithmic phase growth is collected according to 1x105The cell density of cells/ml is inoculated in 96 orifice plates, per hole
100 μ L are inoculated with, while cell controls group is set.Every group is respectively provided with 4 experimental ports.5%CO2,37 DEG C of incubations.
(2) cell length to individual layer, adds in embodiment 3-4 in experimental group after culture for 24 hours, comparative example 1-4 it is obtained into
100 μm of ol/L of product liquid, and continue to cultivate 6h.It is inhaled after 6h and abandons culture medium and add PBS to cell is covered, give UVA irradiations
60min；
(3) drug-treated before abandoning PBS and restoring irradiation is inhaled after irradiation is completed and continues to be incubated for 24 hours；
(4) 10 μ LMTT solution are added in every hole for 24 hours after UVA irradiations, continues to cultivate 4h；
(5) culture is terminated, carefully sucks the culture medium in hole.96 orifice plates are put after adding in 100 μ L dimethyl sulfoxide (DMSO)s per hole
In low-speed oscillation 15min on shaking table, crystal is made fully to dissolve.Each hole is measured under the wavelength condition of 490nm using microplate reader
Light absorption value.Cell survival rate (%)=(ODExperimental group-ODBlank well)/(ODCell controls group-ODBlank well) × 100%
2 each test group cell survival rate result of table
| Group | Cell survival rate (%) |
| Embodiment 2 | 94.0 |
| Embodiment 3 | 93.4 |
| Comparative example 1 | 80.7 |
| Comparative example 2 | 85.8 |
| Comparative example 3 | 74.4 |
| Comparative example 4 | 70.2 |
| Control group | 56.7 |
As seen from the above table, eyeshield composition provided by the invention, which has, preferably prevents UVA from irradiating HaCaT cell photo-damages
Effect, can improve the survival rate of cell, up to more than 93%, be significantly better than eyeshield composition made from comparative example 1-4.
It is prepared by 7 phototherapy safety goggles of embodiment
It is shown referring to Figures 1 and 2, a kind of baby's phototherapy safety goggles, including non-woven fabrics gland band 1, the non-woven fabrics
The left and right sides of gland band 1 is provided with the velcro 5 that can mutually paste, and eyeshade ontology 2 is fixed on non-woven fabrics by sewing 3 and consolidates
Determine the bottom end at 1 middle part of headband, the eyeshade ontology 2 includes the blu-ray reflection film layer 21 being sewed together, inhales successively from outside to inside
Light black cloth layer 22, nanometer silver antimicrobial spunlace non-woven cloth layer 23, spongy layer 24, radiation protection film layer 25, blue scrim layer 26 and profit
Eye mask layer 27.Wherein, eyeshade ontology 2 is the bottom end that 1 middle part of non-woven fabrics immobilizing bandage is fixed on by sewing 3, up-down structure
Composition can facilitate the adjustment of the position on non-woven fabrics gland band 1 of eyeshade ontology 2, when being directed to different infants wearing to facilitate
Adjustment.Eyeshade need to only pass through the cooperation of non-woven fabrics gland band 1 and velcro 5 when wearing, you can paste eyeshade ontology 2
In the eye of infant.Eyeshade ontology 2 is by the blu-ray reflection film layer 21, extinction black cloth layer 22, the nanometer that are sequentially distributed from outside to inside
Silver-colored anti-bacterial water prick nonwoven cloth layer 23, spongy layer 24, radiation protection film layer 25, blue scrim layer 26 and visual function improving film layer 27 sew and
Into wherein blu-ray reflection film layer 21 can reflect more than 80% treatment blue light, and remaining blue light is direct by extinction black cloth layer 22
Absorb, can obstruct more than 98% blue light, remaining blue light due to nanometer silver antimicrobial spunlace non-woven cloth layer 23, spongy layer 24,
Radiation protection film layer 25, blue scrim layer 26 and visual function improving film layer 27 barrier and gradually decay, after testing, can finally pass through profit
The blue light that eye mask layer 27 transmits is less than 0.1%, thus, can thoroughly prevent blue light transmission to infant's eye
Injury.In order to improve the anti-microbial property of this eyeshade ontology 2, spy sets nanometer silver antimicrobial spun lacing behind extinction black cloth layer 22
Nonwoven layer 23 can kill absorption in nanometer silver antimicrobial spunlace non-woven cloth layer 23 with the slow release bactericidal nano-silver factor
Bacterium or germ in eyeshade improve the antibiotic property of this eyeshade.Spongy layer 24 can enhance comfortable when this eyeshade is worn
Property；Radiation protection film layer 25 can enhance protection of this eyeshade in blue-light treatment to other radiation；Blue scrim layer 26 is used
It can suitably enhance gas permeability when eyeshade is worn in further absorption blue light, and by grid cloth；Visual function improving film layer 27 can
To carry out appropriate moistening to infant's eye, when especially wearing eyeshade for a long time, it can prevent to occur that eye is dry and astringent to ask
Topic.
With reference to shown in Fig. 1, the eyeshade ontology 2 by two symmetrically and can symmetrical fold the sewing of eyeshade halfbody and
Into since eyeshade ontology 2 can be split with non-woven fabrics gland band 1, the storage of process being actually used, by eyeshade halfbody phase
It mutually folds, outer layer again mutually folds non-woven fabrics gland band, further protects the visual function improving film layer 27 of 2 innermost layer of eyeshade ontology not
By outside contamination.
With reference to shown in Fig. 1, the non-woven fabrics gland band, which is located at the top of eyeshade ontology 2, is provided with forehead dew hole 4, real
During the use of border, the forehead of infant can be revealed at hole 4 with forehead to be exposed, and is facilitated and is received blue light illumination at infant's forehead；Also
Available for adjusting the position of eyeshade ontology 2, adjustment when being worn suitable for different infants.
In the present embodiment, the visual function improving film layer cover body and ontology composition, the cover body is polyurethane film, described
Ontology is eye-care compositions made from embodiment 3, and the visual function improving film layer is polyurethane film and eye-care compositions
It is prepared by hot press method, the thin polyurethane film thickness is 15mm, and the eye-care compositions thickness is
35mm。
In the present embodiment, the thickness of the nanometer silver antimicrobial spunlace non-woven cloth layer 23 is 0.3mm.Nanometer silver antimicrobial spun lacing without
The thickness of woven fabric layer 23 is unsuitable excessively thin, otherwise the nano silver release sterilization silver ion amount in nanometer silver antimicrobial spunlace non-woven cloth layer 23
Limited, the effect of antibacterial sterilization is limited；The thickness of nanometer silver antimicrobial spunlace non-woven cloth layer 23 is also unsuitable blocked up simultaneously, otherwise not only
Production cost can be increased, and the gas permeability of eyeshade can be influenced.It is found by many experiments, when nanometer silver antimicrobial spunlace non-woven cloth
When the thickness of layer 23 is 0.3mm, enough nano silvers can be both stored, the effect of antibacterial sterilization is good, and does not influence eyeshade again
Gas permeability.
In the present embodiment, 2 each functional layer of eyeshade ontology takes ultraviolet lamp or ethylene oxide to go out during sewing
The mode of bacterium, is handled, and is reached microbial limit requirement of the country to medical product by detection, is greatly reduced eyes sense
The chance of dye.
8 phototherapy safety goggles of embodiment use sensory evaluation
Volunteer patients 100 are screened, are randomly divided into 5 groups, every group of 20 people, respectively embodiment 3, comparative example 1-4 groups, each group
Use the phototherapy safety goggles containing eyeshield composition made from embodiment 3, comparative example 1-4 respectively, continuous wear 6h, evaluate with
And use feeling, according to using effect 0~10/marking, 9~10 points are fine, and 7~8 points are preferable, and 5~6 points are
Generally, 3~4 points are poor, and 1~2 point is very poor, and 0 point is insentience, is averaged.As a result it see the table below shown in 3.
3 each test group of table uses Analyses Methods for Sensory Evaluation Results
| Index | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 |
| Comfortably | 9.4 | 8.8 | 8.2 | 6.8 | 7.8 |
| Salubrious degree | 8.5 | 8.5 | 7.5 | 7.2 | 7.4 |
| Moistness | 8.8 | 8.2 | 7.2 | 5.4 | 4.8 |
| Irritation | 0 | 0 | 0 | 0 | 0 |
It is as seen from the above table, good using the phototherapy safety goggles comfort containing eyeshield composition made from the embodiment of the present invention 3,
Compliance is high, is significantly better than eyeshield composition made from comparative example 1-4.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be subject to claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, several improvements and modifications can also be made, these change
Protection scope of the present invention is also should be regarded as into retouching.
Claims (7)
1. a kind of eye-care compositions, which is characterized in that the composition includes following component and its parts by weight：Shell gathers
Sugared 10 ~ 30 parts of nanoparticle, 10 ~ 30 parts of fibroin albumen, 20 ~ 30 parts of pearl active peptide, 5 ~ 15 parts of L-Pyrrolidone Carboxylic Acid sodium, Radix Glycyrrhizae
Sour 10 ~ 15 parts of sodium, 40 ~ 60 parts of xanthans；
Active components of plants is embedded with inside the chitosan nano, the active components of plants is by Gotu Kola P.E
With Rosmarinic acid with 1:0.05 ~ 0.2 mass ratio composition；Content of the active components of plants in chitosan nano be
0.1~10%( m/m)；
The preparation of the pearl active peptide includes the following steps：
（1）Pearl is taken, is ground to fine powder, using solid-liquid ratio as 1:5 ratios add in 60%（m/v）Sodium lactate aqueous solution, ultrasound is mixed
It is even, add in malic acid while stirring, until dissolving is complete, make malic acid in system final concentration of 0.1 ~ 0.3%, in room temperature
Under, normal pressure forward current is first passed through into solution, high-frequency high-voltage is passed through after being passed through the reversed current processing 6s of normal pressure after processing 12s
Stream is cut off the power after handling 60 ~ 90min, and the frequency of the high-frequency high-voltage current is 6000 ~ 9000 hertz, voltage for 4000 ~
8000 volts, obtain treatment fluid；
（2）Toward step（1）Appropriate glycine buffer is added dropwise in obtained treatment fluid, modulation pH to neutrality is then centrifuged for, and is received
Collect supernatant, by supernatant be dried under reduced pressure to get.
2. eye-care compositions according to claim 1, which is characterized in that the composition include following component and
Its parts by weight：25 parts of chitosan nano, 15 parts of fibroin albumen, 25 parts of pearl active peptide, 5 parts of L-Pyrrolidone Carboxylic Acid sodium,
15 parts of Carbenoxolone Sodium, 50 parts of xanthans.
3. eye-care compositions according to claim 1, which is characterized in that the preparation packet of the chitosan nano
Include following steps：
（1）It weighs active components of plants and is dissolved in absolute ethyl alcohol, the ethanol solution of a concentration of 0.01 ~ 0.1mg/mL is made, cross 0.4 μm
Filter, it is spare；
（2）Chitosan is weighed, is dissolved in 1% acetic acid, the chitosan solution of a concentration of 0.5 ~ 2mg/mL is made, is added dropwise under stiring
Step（1）Ethanol solution obtained, 2 ~ 3min of magnetic agitation continuously add tripolyphosphate sodium water solution, stir 1 ~ 3min, obtain instead
Answer liquid；
（3）By step（2）Reaction solution obtained centrifuges 2 ~ 3min, precipitation is taken, by precipitation PBS in 4 DEG C, 10000 rpm/min
Buffer solution for cleaning 3 times, be dried under reduced pressure to get.
4. eye-care compositions according to claim 3, which is characterized in that the step（2）The trimerization of middle addition
Final concentration of 0.1 ~ 0.2% (m/m) of the sodium phosphate in system.
A kind of 5. method for preparing eye-care compositions as described in claim 1, which is characterized in that include the following steps：
（1）Xanthans and chitosan nano are weighed, is mixed, suitable quantity of water is added in and is swollen, in a manner of equal increments, stirred
Fibroin albumen, pearl active peptide, L-Pyrrolidone Carboxylic Acid sodium and the Carbenoxolone Sodium mixed liquor dissolved in advance is added under the conditions of mixing,
5 ~ 10min of magnetic agitation, obtains finished fluid；
（2）It will（1）Obtained finished fluid injects mold under vacuum, cured, and ultraviolet sterilization is carried out after demoulding to get eye
Portion's care composition.
6. a kind of baby's phototherapy safety goggles, which is characterized in that including：Non-woven fabrics gland band, the non-woven fabrics gland band
The left and right sides be provided with the velcro that can mutually paste, eyeshade ontology is fixed on by sewing in the middle part of non-woven fabrics gland band
Bottom end, the eyeshade ontology include the blu-ray reflection film layer being sewed together, extinction black cloth layer, nano silver and resist successively from outside to inside
Bacterium spunlace non-woven cloth layer, spongy layer, radiation protection film layer, blue scrim layer and visual function improving film layer；
The visual function improving film layer is made of cover body and ontology, and the cover body is polyurethane film, and the ontology will for right
Eye-care compositions made from 5 are sought, the visual function improving film layer passes through hot moulding for polyurethane film with eye-care compositions
Technique is prepared, and the thin polyurethane film thickness is 10 ~ 20mm, and the eye-care compositions thickness is 30 ~ 50mm.
7. baby's phototherapy safety goggles according to claim 6, which is characterized in that the eyeshade ontology is mutually right by two
Claim and can the eyeshade halfbody of symmetrical fold sew；The non-woven fabrics immobilizing bandage, which is located at the top of eyeshade ontology, to be provided with
Forehead reveals hole；The thickness of the nanometer silver antimicrobial spunlace non-woven cloth layer is 0.2 ~ 0.5mm.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103333222A (en) * | 2013-07-10 | 2013-10-02 | 浙江长生鸟珍珠生物科技有限公司 | Pearl natural active peptide having whitening efficacy, and extraction method and application thereof |
| CN104127386A (en) * | 2014-07-22 | 2014-11-05 | 武汉工程大学 | Rubimaillin/chitosan nanoparticle, and preparation method and application thereof |
| CN106726917A (en) * | 2016-12-15 | 2017-05-31 | 广州睿森生物科技有限公司 | A kind of eyeware products and solution for lenses and contact lenses |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103333222A (en) * | 2013-07-10 | 2013-10-02 | 浙江长生鸟珍珠生物科技有限公司 | Pearl natural active peptide having whitening efficacy, and extraction method and application thereof |
| CN104127386A (en) * | 2014-07-22 | 2014-11-05 | 武汉工程大学 | Rubimaillin/chitosan nanoparticle, and preparation method and application thereof |
| CN106726917A (en) * | 2016-12-15 | 2017-05-31 | 广州睿森生物科技有限公司 | A kind of eyeware products and solution for lenses and contact lenses |
Non-Patent Citations (1)
| Title |
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| 迷迭香酸的提取纯化及生物活性研究进展;程贤等;《林产化学与工业》;20150831;151-158 * |
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