CN107569764B

CN107569764B - Based on little electromagnetism anus intestines postoperative device of dosing of PDMS

Info

Publication number: CN107569764B
Application number: CN201710734299.7A
Authority: CN
Inventors: 任鹏涛; 张苑
Original assignee: Individual
Current assignee: Second Hospital of Hebei Medical University
Priority date: 2017-08-24
Filing date: 2017-08-24
Publication date: 2020-04-21
Anticipated expiration: 2037-08-24
Also published as: CN107569764A

Abstract

The invention discloses a PDMS (polydimethylsiloxane) -based micro-electromagnetic anorectal postoperative drug delivery device which comprises an outer sleeve (1), a drug delivery channel (2), a piezoelectric driver (3), a buffer pool (4), a drug inlet channel (5), an electromagnetic driver (6), a drug pool (9) and a normally closed micro valve (10), wherein the normally closed micro valve (10) consists of a valve plate (7) and a valve plug (8). The right side of the outer sleeve (1) is connected with a drug administration channel (2); the right side of the drug delivery channel (2) is provided with a piezoelectric driver (3), and the two ends of the piezoelectric driver are respectively connected with the drug delivery channel (2) and the buffer pool (4) through a normally closed micro valve (10); the lower part of the drug feeding channel (2) is connected with a drug feeding channel (5) through a normally closed micro valve (10), the lower part of the drug feeding channel (5) is connected with an electromagnetic driver (6), and the lower part of the electrical driver (6) is connected with a drug pool (9) through the normally closed micro valve (10). The invention adopts a flat micro-valve structure, overcomes the multi-layer complex structure of the existing mechanical micro-pump, can effectively inhibit the reverse leakage of the liquid medicine, can meet the requirement of administration at millisecond level, has the advantages of convenient symptomatic administration, soft administration process, prevention of medicament backflow and impact on the affected part, convenient carrying, more simplicity and high efficiency, and reduces the cost.

Description

Based on little electromagnetism anus intestines postoperative device of dosing of PDMS

Technical Field

The invention relates to the technical field of medical treatment, in particular to a PDMS (polydimethylsiloxane) -based micro-electromagnetic anorectal postoperative drug delivery device.

Background

Anorectal diseases are frequently encountered diseases, such as anal fistula, hemorrhoids, colon cancer and the like. Especially after anal fistula operation, the lower anal fistula is not directly closed after being cut, but is administrated, so that the second healing is mainly performed. The anorectal diseases always disturb the health of human beings for a long time, and how to solve and treat the anorectal diseases becomes an important subject faced by the scientific community at present and is a hot spot and a difficult point of international research at present. Because the operation part is easily polluted by excrement, defecation stimulation and other factors, certain adverse effects are brought to the life quality of a postoperative patient and the healing of a wound surface, and complications such as wound edge edema, pain, much secretion of the wound surface and the like occur.

In the administration process, the change condition of secretion of the wounded surface, the change of the number of giant peak cells in a wound surface exudate printing sheet, the growth integral of granulation on the wound surface, the healing time of the wound surface and the like need to adjust the dosage and the administration duration in real time.

At present, the conventional anorectal medical administration equipment generally has the problems of overlarge administration amount (relative to nano-scale), slow administration response time (relative to millisecond scale), complex operation, expensive equipment and the like, and cannot administer medicine at any time and any place.

In addition, in view of the current development of microfluidic technology, the process of administering drugs using microvalves is: when the medicine is used each time, the medicine reagent and the buffer solution are required to be injected into the medicine feeding channel and the medicine feeding channel in advance, and then medicine feeding and medicine feeding are carried out through an external driving source, so that the integration is lacked, and the use is inconvenient. Additionally, how to reduce the reverse leakage of the micro valve is a problem in that the medicine is easily returned due to the insufficient power of the micro pump. Therefore, how to reduce postoperative complications, relieve pain of patients, promote the growth of postoperative wound surfaces and promote early recovery is always the aim of the medical science and technology workers in the anorectal field.

Disclosure of Invention

Based on the defects of the prior art, the invention aims to provide a PDMS-based micro-electromagnetic anorectal postoperative drug delivery device to solve the problems in the background art.

In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a little electromagnetism anus intestines postoperative drug delivery device based on PDMS, includes overcoat 1, dose passageway 2, piezoelectric actuator 3, buffer pool 4, advances medicine passageway 5, electromagnetic actuator 6, medicament pond 9 and normally closed microvalve 10. The normally closed micro valve 10 is composed of a valve plate 7 and a valve plug 8, and adopts a zero-clearance contact PDMS plane micro valve structure, so that the flow direction of liquid can be effectively controlled, and the reverse leakage of the liquid is reduced.

The right side of the outer sleeve 1 is connected with a drug administration channel 2; the right side of the drug delivery channel 2 is provided with a piezoelectric driver 3, and the two ends of the piezoelectric driver are respectively connected with the drug channel 2 and the buffer pool 4 through a normally closed micro valve 10; the lower part of the drug feeding channel 2 is connected with a drug feeding channel 5 through a normally closed micro valve 10, the lower part of the drug feeding channel 5 is connected with an electromagnetic driver 6, and the lower part of the electrical driver 6 is connected with a drug pool 9 through the normally closed micro valve 10.

The electromagnetic driver 6 is a four-layer packaging structure of a PDMS electromagnetic driving micropump, the uppermost layer is a PDMS packaging layer 11 with a hollow structure, a PDMS pump membrane 13 is arranged below the PDMS packaging layer 11, a PDMS pump body 14 is connected below the PDMS pump membrane 13, and a PDMS substrate 17 is arranged below the PDMS pump body 14.

A permalloy sheet 12 is arranged above the surface of the PDMS pump film 13; the bottom layer of the PDMS pump film 13 is a silicon wafer layer 1303, a PE film 1302 is arranged above the silicon wafer layer 1303, a PDMS film 1301 is arranged above the PE film 1302, a copper ion layer 1305 is arranged above the PDMS film 1301, an S1818 photoresist layer 1304 is arranged above the copper ion layer 1305, and a groove is formed in the middle of the S1818 photoresist layer and used for placing the permalloy sheet 12.

The PDMS pump body 14 is provided with a pump cavity 15 in the middle, and a valve plug channel 16 is provided on the right side of the pump cavity 15.

In a further scheme of the invention, a C-shaped buffer baffle plate 101 is arranged at the left outlet of the outer sleeve 1.

In a further embodiment of the present invention, the permalloy plate 12 is a driving plate with a thickness of about 20um formed by deposition on the plating region of the PDMS film 1301 through a plating process.

In a further embodiment of the present invention, the electromagnetic actuator 6 is a four-layer PDMS package structure, which is sealed with peroxide glue, and the inlet/outlet port thereof is connected to the catheter.

Compared with the prior art, the invention has the beneficial effects that: the flat micro-valve structure is adopted, the close fit gapless characteristic of the valve plate 7 and the valve plug 8 and the reverse stopping performance of the micro-valve set are greatly exerted by combining the PDMS four-layer demoulding design and the photoetching process, the multi-layer complex structure of the existing mechanical micro-pump is overcome, the reverse leakage of liquid medicine can be effectively restrained, the millisecond-level administration requirement can be met, meanwhile, the administration dosage and time can be accurately controlled, and tests show that the administration of 10-50nL trace pharmaceutical reagents can be achieved within 60 ms; the advantages of convenient symptomatic medication, soft administration process, C-shaped buffer structure, convenient carrying, more simplicity and high efficiency, and can prevent the backflow of the medicament and the impact on the affected part, thereby reducing the cost.

Drawings

Fig. 1 is a general structural schematic diagram of a PDMS-based micro-electromagnetic anorectal postoperative drug delivery device.

Fig. 2 is a schematic diagram of the operation of the drug delivery system of the present device: a quiescent state.

Fig. 3 is a schematic diagram of the operation of the drug delivery system of the present device: the medicine is taken.

Fig. 4 is a schematic diagram of the operation of the drug delivery system of the present device: the state of administration.

Fig. 5 is a schematic structural diagram of the PDMS micropump electromagnetic drive.

Fig. 6 is a cross-sectional view taken along line a-a of fig. 5, illustrating the operation of the electromagnetic actuator.

FIG. 7 is a schematic layout view of the permalloy plate and the PDMS pump film in FIG. 5.

Fig. 8 is a schematic structural diagram of a PDMS pump film. (wherein a, b, c are the order of carrying out the process)

Fig. 9 is a schematic view of a structure of a microvalve.

Fig. 10 is a schematic view of the buffering structure at the drug outlet in the jacket.

In the figure: an outer sleeve 1; a buffer spacer 101; an administration channel 2; a piezoelectric driver 3; a buffer tank 4; a medicine inlet passage 5; an electromagnetic driver 6; a valve plate 7; a valve plug 8; a medicament reservoir 9; a normally closed microvalve 10; a PDMS encapsulation layer 11; a permalloy sheet 12; a PDMS pump membrane 13; a PDMS film 1301; a PE film 1302; a silicon layer 1303; s1818, the optical cement layer 1304; a copper ion layer 1305; a PDMS pump body 14; a pump chamber 15; a plug passageway 16; a PDMS substrate 17.

Detailed Description

Referring to fig. 1 to 10, in order to make the technical contents and construction features of the present invention more easily understood by those skilled in the art, the present invention will be further described with reference to the technical points and the accompanying drawings.

The first embodiment is as follows:

the invention provides a PDMS (polydimethylsiloxane) -based micro-electromagnetic anorectal postoperative drug delivery device which comprises an outer sleeve 1, a drug delivery channel 2, a piezoelectric driver 3, a buffer pool 4, a drug inlet channel 5, an electromagnetic driver 6, a drug pool 9 and a normally-closed micro valve 10. The normally closed micro valve 10 is composed of a valve plate 7 and a valve plug 8, and adopts a zero-clearance contact PDMS plane micro valve structure, so that the flow direction of liquid can be effectively controlled, and the reverse leakage of the liquid is reduced.

The left outlet of the jacket 1 is also provided with a C-shaped buffer baffle 101 for preventing and buffering the impact force of the fluid medicament.

Example two:

as shown in fig. 5, positive pressure and negative pressure are respectively formed in the pump cavity 15, and they are easily counteracted by resonance, so that the net flow of the micro pump is significantly reduced, which is not beneficial to the outflow of the medicament.

The side length A of the pump film is taken as a reference side length, the permalloy structure and the position parameter B, C, D are subjected to standardization treatment, and the Young modulus of a permalloy sheet and the PDMS pump film is set as follows: 230GPa and 0.95 MPa. The optimization data obtained after finite element analysis by the CoMSOLMultiphysics method is as follows: the side length and the height of the pump cavity 15 are selected to be 5mm and 1800um, and the permalloy structure and the position parameter B, C, D are respectively 0.15mm, 2.04mm and 0.6 mm; the thickness of the permalloy sheet is 20 um.

Example three:

as shown in fig. 8, the PE film 1302 serves to provide a substrate support for the PDMS pump film 13, facilitating replacement or peeling from the silicon wafer layer.

The copper ion layer 1305 is a layer of copper metal ions with a thickness of about 50um deposited on the PDMS film 1301 by an electron beam sputtering method, and has the function of ensuring sufficient adhesive force between the permalloy sheet 12 and the PDMS pump film 13 and preventing the electroplated permalloy sheet from falling off in the electroplating process.

The S1818 photoresist layer is a photoresist of thickness 20um, forming a permalloy plated region as shown in fig. 8 (b).

The permalloy sheet 12 is a driving sheet of about 20um formed by deposition on the plating area of the PDMS film 1301 through a plating process.

Example four:

as shown in fig. 5, in the PDMS micro-electromagnetic driving design, the encapsulation of the four layers of PDMS sheets of the electromagnetic driver 6 is mainly performed in an ion reactive etcher by using a plasma oxidation treatment method. Sealing four layers of PDMS sheets from bottom to top, placing the PDMS sheets on a hot plate, heating the PDMS sheets at 80 ℃ for 12 minutes to seal the PDMS sheets, and finally connecting the inlet and outlet of the electromagnetic driver 6 with a catheter and sealing the catheter with peroxide glue.

Example five:

the externally applied magnetic field of the electromagnetic driver 6 can adopt a remote control electromagnetic controller (E363IA model agilell), and the on and off time of a power supply is controlled by using a computer Labview programming program to generate a medicine feeding pulse signal or a medicine administration pulse signal, so as to realize the remote control of the medicine feeding process and the medicine administration process.

A device theory of operation based on little electromagnetism anus intestines postoperative of PDMS:

as shown in the operation schematic diagram of fig. 6, in the static state, no external magnetic field acts on the permalloy sheet 12 during the PDMS micro-electromagnetic driving process, so the pump film is not deformed and is in a flat standby state.

Under the driving state, the permalloy sheet 12 is magnetized under the action of an external magnetic field, and interacts with a magnetic field in the vertical direction to generate magnetic torque, so that the PDMS pump film 13 is driven to deform, the volume and the pressure of the pump cavity 15 are changed, and further, the fluid is driven. Similarly, by applying a cyclically reciprocating alternating magnetic field to act on the electromagnetic driver 6, the pump membrane is made to generate reciprocating vibration, and then the one-way continuous flow of the fluid medicament is realized by matching with the flow direction control action of the micro valve 10. Control pulse signals are applied to the inlet ends of the medicine feeding channel and the medicine feeding channel, the medicine feeding and medicine feeding processes are accurately controlled, and the accurate control of the medicine feeding reagent amount and the medicine feeding time is realized.

The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. A PDMS-based micro-electromagnetic anorectal postoperative drug delivery device comprises an outer sleeve (1), a drug delivery channel (2), a piezoelectric driver (3), a buffer pool (4), a drug inlet channel (5), an electromagnetic driver (6), a drug pool (9) and a normally closed micro valve (10); the method is characterized in that: the normally closed micro valve (10) consists of a valve plate (7) and a valve plug (8), and adopts a zero-clearance contact type PDMS planar micro valve structure; the right side of the outer sleeve (1) is connected with a drug administration channel (2); the right side of the drug delivery channel (2) is provided with a piezoelectric driver (3), and the two ends of the piezoelectric driver are respectively connected with the drug delivery channel (2) and the buffer pool (4) through a normally closed micro valve (10); the lower part of the drug feeding channel (2) is connected with a drug feeding channel (5) through a normally closed micro valve (10), the lower part of the drug feeding channel (5) is connected with an electromagnetic driver (6), and the lower part of the electromagnetic driver (6) is connected with a drug pool (9) through the normally closed micro valve (10);

the electromagnetic actuator (6) is a four-layer packaging structure of a PDMS electromagnetic drive micropump, the uppermost layer is a PDMS packaging layer (11) with a hollow structure, a PDMS pump membrane (13) is arranged below the PDMS packaging layer (11), a PDMS pump body (14) is connected below the PDMS pump membrane (13), and a PDMS substrate (17) is arranged below the PDMS pump body (14);

a permalloy sheet (12) is arranged above the surface of the PDMS pump film (13); the bottom layer of the PDMS pump film (13) is a silicon wafer layer (1303), a PE film (1302) is arranged above the silicon wafer layer (1303), a PDMS film (1301) is arranged above the PE film (1302), a copper ion layer (1305) is arranged above the PDMS film (1301), an S1818 photoresist layer (1304) is arranged above the copper ion layer (1305), and a groove is formed in the middle of the S1818 photoresist layer and used for placing a permalloy sheet (12);

the PDMS pump body (14) middle part is equipped with a pump chamber (15), and the right side of pump chamber (15) is equipped with a valve plug passageway (16).

2. The PDMS based micro-electromagnetic anorectal post-operation drug delivery device according to claim 1, wherein: and a C-shaped buffer baffle plate (101) is arranged at the left outlet of the outer sleeve (1).

3. The PDMS based micro-electromagnetic anorectal post-operation drug delivery device according to claim 1, wherein: the permalloy sheet (12) is a driving sheet with a thickness of 20 microns formed by deposition in a plating area of the PDMS film (1301) through a plating process.

4. The PDMS based micro-electromagnetic anorectal post-operation drug delivery device according to claim 1, wherein: the electromagnetic driver (6) is a four-layer PDMS packaging structure, is sealed by peroxide glue, and is connected with a conduit at an inlet and outlet channel port thereof.