CN107569684A - Formula for growing hair - Google Patents

Abstract

The present invention relates to the non-corrosion-resistant non-aqueous based formulations for hair growth.Specifically, the present invention relates to the non-aqueous hair of active eicosanoids acid and eyelashes growth preparation, it is free of preservative.

Description

Formula for growing hair

Technical field

Generally, the present invention relates to hair growth stimulant compositions and preparation.Specifically, the present invention relates to active eicosanoids The non-aqueous hair growth agent of acid, it is free of preservative.

Background technology

Have proven to prostaglandin and forefront acid amides (prostamides) can be used for promoting hair growth.Prostanoid (prostanoid) in addition to the eyelashes and eyebrow that make patients undergoing chemotherapy recover normal, also received an acclaim simultaneously because that can grow eyelashes Obtain business success.Latanoprost (latanoprost), bimatoprost (bimatoprost), travoprost (travoprost) and effect of the related material of pharmacology for eyelashes is faced what is carried out for glaucoma patient Found in bed experiment.U.S. Patent No. 6,626,105 (being included herein in a manner of citation) is instructed prostaglandin and its spread out Biology provides the useful compound for promoting eyelashes growth.According to another report, bimatoprost causes the growth of people's eyelashes.Hereafter, exist Occur a large amount of reports in terms of prostanoid and eyelashes and other hair growths, propose a large amount of patent applications, such as the U.S. is special Profit the 8th, 227,514, is included in a manner of citation herein.For bimatoprost, have proven to it and promote ciliogensis The long mechanism of action increases with entering the eyelashes in growth period (anagen) and relevant (the Br J of the extension in growth period Dermatol.2010 June, 162 (6):1186-97.Characterization of an in vivo model for the study of eyelash biology and trichomegaly:mouse eyelash morphology, development,growth cycle,and anagen prolongation by bimatoprost.TauchiM,Fuchs TA,KellenbergerAJ,WoodwardDF,PausR,Lütjen-Drecoll E).Report bimatoprost in vitro People's scalp hair follicles also have the similar mechanism of action (FASEB J.2013 year 2 months, 27 (2):557-67.Theprostamide- related glaucoma therapy,bimatoprost,offers a novel approach for treating scalp alopecias.KhidhirKG,WoodwardDF,FarjoNP,FarjoBK,TangES,WangJW, PicksleySM,Randall VA)。

The content of the invention

The non-aqueous based formulations and method for preparing trichogenous eicosanoid are described, so as to improve class flower The chemical stability of raw acid and its prodrug, and preservative need not be used in preparation.The hair growth product of bulk packages can include Pot-life used in everyday after preservative (although this is optionally) is opened with extension.The non-aqueous based formulations are by naturally occurring Composition be made.These preparations can be delivered by saving dosage and facilitating the method and apparatus of patient.Particularly practical is to match somebody with somebody There is the positive displaced type of felt/fiber tip or special brush (positive displacement) cylindrical appliance directly to apply Smear in margo palpebrae.Such delivering method can reduce the risk that medicine is applied to the position (such as eyeball and conjunctiva) for being not desired to smear. In addition, preparation includes, addition is natural to be promoted hair shaft and hair follicle health and improves the essential oil and vegetable oil of outward appearance.

One aspect of the present invention includes being used for the method for treating alopecia or alopecia and/or the feature related to alopecia, The feature related to alopecia is, for example, hypotrichosis, achromotrichia, the speed drop without the growth of new hair shaft, hair shaft growth Low, hair shaft diameter (thickness) reduces, hair shaft length reduces, hair density reduces, trichochromes calmness is reduced, the generation of melanin Reduce, the keratinization of hair shaft is reduced, hair shaft gloss reduces, hair health reduces, the fragility of hair shaft increases, hair follicle is in growth period The time in stage is reduced, hair follicle is in the time reduction in catagen (catagen) stage, hair follicle is in stand-down (telogen) Time in stage reduces, external (exogen) in the stage hair shaft discharge too early since hair follicle, the Apoptosis in hair follicle too early, Too early conversion of the terminal hair to hair, hair convert to terminal hair to fail.

Brief description of the drawings

Fig. 1 shows an embodiment of the applicator for the present invention；

Fig. 2 shows the result for not having bacterium and fungi growth on the preparation 3 of table 1, as described in example 1 above.

Embodiment

Herein, term " about ", " about " and " approximately " are used to modify numerical value and represent the definition near the value Scope.If " x " is value, " about x " " is approximately equal to the value that x " generally represents 0.90x to 1.10x.It is any refer to " about x " is most Represent lower bound degree at least value x, 0.90x, 0.91x, 0.92x, 0.93x, 0.94x, 0.95x, 0.96x, 0.97x, 0.98x, 0.99x, 1.01x, 1.02x, 1.03x, 1.04x, 1.05x, 1.06x, 1.07x, 1.08x, 1.09x and 1.10x.Therefore, " about x " It is intended to open such as " 0.98x ".When " about " is used for before number range, it holds for modifying two of the scope simultaneously Point.Therefore, " about 6 to 8.5 " are equal to " about 6 to about 8.5 ".When " about " is used for first value of a class value, it is used to modify The all values of the group.Therefore, " about 7,9 or 11% " are equal to " about 7%, about 9% or about 11% "." about " can also refer to close to pipe The numeral that can bring bioequivalence therapeutic effect of numeral is lifted by reason mechanism (such as FDA or EMEA).

" alopecia " is defined as alopecia and the alopecia hypotrichosis including eyelashes or eyebrow, and may include different types of de- Disease is sent out, it includes but is not limited to alopecia areata, alopecia cicatrisata, non-alopecia cicatrisata, androgenetic alopecia (androgenetic Alopecia), telogen effluvim, trichologia, general alopecia and whole alopecia, transience alopecia areata, alopecia generalisata.

" hypotrichosis disease " is the illness of abnormal trichomadesis or reduction.

" non-aqueous based formulations " can refer to water-free preparation.

" vegetable oil " can refer to the oil from plant origin.Mainly have the vegetable oil of three types, their difference be from The mode of plant region of interest extraction and the property of gained oil：(1) vegetable oil, in history by the way that plant parts are placed under pressure Expressed oil and extract；(2) macerate oily (Macerated oil), be made up of the base oil that with the addition of plant parts；(3) essential oil, by Volatile aromatic compounds form, by distilling from plant extract." preservative free applicator is used for multiple times " refers to provide The applicator of the non-preservative of multiple dose.

" prostanoid " can refer to such as prostaglandin, prostacyclin (prostacyclin), thromboxane (thromboxanes) and an eicosanoid of forefront acid amides etc. subclass.

" treatment ", which can refer to, cures any disease or illness or mitigation or the symptom for alleviating disease or illness.

Some embodiments of the present invention include：

1) a kind of non-aqueous non-preservative, it is used to treat selected from the few hair of eyelashes depilation, the few hair of eyebrow depilation or head One kind in the few hair of skin alopecia, it is made up of bimatoprost, ethanol and oil.

2) the non-aqueous non-preservative of embodiment 1, wherein the preparation is used for the hypotrichosis disease for treating eyelashes, and compare Bimatoprost exists with 0.01%-0.03%w/v concentration.

3) the non-aqueous non-preservative of embodiment 2, wherein the preparation is applied at least one margo palpebrae to control Treat the hypotrichosis disease of eyelashes.

4) the non-aqueous non-preservative of embodiment 3, wherein the preparation is applied into upper eyelid margin.

5) the non-aqueous non-preservative of embodiment 4, wherein the preparation is smeared once daily.

6) the non-aqueous non-preservative of embodiment 5, wherein the oil is vegetable oil, such as jojoba oil, castor-oil plant Oil, avocado oil, olive oil, Sweet Almond Oil and optionally at least a kind of essential oil.

7) the non-aqueous non-preservative of embodiment 6, wherein the vegetable oil is selected from avocado oil, olive oil and sweet tea apricot Benevolence oil.

8) the non-aqueous non-preservative of embodiment 7, wherein the preparation also includes vitamin E.

9) the non-aqueous non-preservative of embodiment 1, its include bimatoprost, absolute ethyl alcohol, castor oil and/or Jojoba oil.

10) the non-aqueous non-preservative of embodiment 9, it includes about 0.03%w/v bimatoprost, about 1% V/v ethanol, about 3%v/v castor oil and about 96%v/v jojoba oil.

11) preparation of embodiment 2, wherein the preparation is applied into margo palpebrae by the way that applicator is used for multiple times.

12) preparation of embodiment 2, its include 0.02%-0.03%w/v bimatoprost, about 1%v/v ethanol, About 3%v/v castor oil and about 70-96%v/v jojoba oil.

13) preparation of embodiment 12, it includes 0.02%w/v bimatoprost.

14) preparation of embodiment 13, wherein, the bimatoprost with smearing 0.03%w/v once in margo palpebrae daily Solution ratio, the preparation smeared once in margo palpebrae daily avoid the side effect to eyes to a greater degree.

15) preparation of embodiment 13, wherein, the bimatoprost solution ratio with 0.03%w/v, smear the preparation So that the bimatoprost that margo palpebrae is delivered to by single smearing is more.

16) preparation of embodiment 13, wherein, the bimatoprost solution ratio with 0.03%w/v, the preparation is brought Identical or more preferable eyelashes growth.

17) preparation of embodiment 2, wherein smearing trouble of the patient of the preparation once than not smearing the preparation daily The eyelashes of person are longer, closeer and more black.

18) preparation of embodiment 2, wherein be applied to the preparation of upper eyelid margin once daily caused eyelashes in 60 days It is longer.

19) preparation of embodiment 1, wherein at the preparation is applied in upper eyelid margin, eyebrow and scalp one.

20) preparation of embodiment 19, wherein the preparation at least one of causes in eyelashes, eyebrow and hair of scalp Hair growth promote.

21) a kind of preparation grown for eyelashes or eyebrow, its any preparation in table 1-4.

22) a kind of preparation for being used for hair of scalp growth or eyebrow hair growth, its any formula in table 1-4.

23) preparation of embodiment 22, wherein the preparation is applied into eyebrow or scalp once a day.

24) preparation of embodiment 22, wherein the preparation is applied into eyebrow or scalp twice daily.

25) preparation of embodiment 23, wherein smearing once a day causes hair of scalp or eyebrow to grow and promote.

26) one be selected from bimatoprost, Latanoprost, tafluprost (tafluprost) and travoprost Kind be used for promote selected from eyelashes growth, eyebrow growth or hair of scalp growth in a kind of purposes.

27) prostanoid and natural oil, for strengthening activity, improving hair appearance, the nutrition of offer hair follicle, enhancement hair shaft Curling or enhancing dissolubility, the natural oil are selected from the essential oil of following plants：Radix Angelicae Sinensis, peru balsam, sweet basil, camphor, cannabis, Cardamom, carrot seed, deodar, chamomile, calamus, Chinese cassia tree, cistus creticus, citron, lemongrass, Salvia japonica, cloves, caraway, the banksia rose, Cranberry seed, fennel seeds, cypress face cream, Artemisia pallens, elecampane, eucalyptus, anise seed, frankincense, galangal, galbanum, fish pelargonium, Huang Flower, grapefruit seed, garden balsam, strawflower, hickory nut, Idaho tansy, jasmine, gin, bay, lavender, Du Xiang, lemon Grass, citrus, peppermint Mai, Moringa, bee saage peppermint, argy wormwood, myrrh, flores aurantii, cardamom, caraway, wrinkled giant hyssop, purple perilla, peppermint, Petitgrain, The fleece-flower root, Chinese larch, rose, fructus rosae, rosemary, rosewood, Salvia japonica, yellow camphor tree, the fruit of Chinese magnoliavine, rhizoma nardostachyos, dragon spruce, anise, tea tree, Thyme, fine jade precipice Malus spectabilis, black tonka-bean, vetiver, western Western Red Cedar, Chinese ilex, milfoil, Yilan.In addition, from plant and its seed The triglyceride of extraction can be used as solvent, medicinal and/or property used for cosmetic, and it may be selected from following vegetable oil：Almond, Morocco Nut, avocado, beech nut, currant seed, Bertholletia excelsa, Pumpkin Seed, oil tea (tea-seed oil), cape Chinese chestnut, cashew nut, Castor oil, cupu oil, coconut, corn, cottonseed, linseed, grape pip, fibert, cannabis seeds, jojoba oil, kapok seed, kind Sub- bluish dogbane, okra seed, olive, palm, peanut, pomegranate seed, poppy seed, soybean, sunflower seed and its mixture.

28) a kind of composition for hair growth, it includes oil formulation and eicosanoid.

29) composition of embodiment 28, wherein the oil formulation is non-aqueous.

Generally, prostanoid is formulated as the aqueous solution, dropped on brush, be then coated in eyelashes root.The eyelash of FDA approvals Hair growth productSituation so is exactly.However, the aqueous solution accelerates the chemically unstable of eicosanoid and its prodrug Property.For example, prostanoid FP receptor stimulating agent prodrugs Latanoprost (In biologically active prod composition) in water It is easy to be hydrolyzed in solution, so being required Storage in refrigerator to postpone this naturally de- ester phenomenon.With eye drop products class Seemingly, ciliogensis long products are typically formulated as the aqueous solution and comprising the preservatives shown in for example following patents：US 20080275118th, EP 2498783, WO 2012038469, WO 2014158373 and US 20150025097, with the side of citation Formula includes its whole.The ester group that can prevent prostanoid prodrug using non-aqueous based formulations (such as those described above) takes off ester.This A little prodrugs can be Arrcostab (Stjernschantz et al., 1992；US 5510383, US 8,865,766) or phosphate (WO 2014070784), its full text is all included in a manner of citation.The prostanoid with cyclopentenone ring is also easy in structure It is dehydrated on Yu Conghuan and loses H₂O parts, and this process may accelerate in aqueous formulation.

In addition, the brush provided in medicine box be abandon and be only used for after using eye it is disposable (Referring to products instruction).There is inevitably waste in this process and raw material are expensive.For example, every thousand The price of gram bimatoprost is about 1,200,000 dollars, and it is very expensive for thus be accordingly used in hair growth agent.It is moreover, every Brush uses after must must dipping in full aqueous formulation, and most of preparation is not transferred on eyelid but is inevitably detained In the brush being dropped after a single use.In addition, the aqueous solution drops down from brush sometimes.

Generally, preservative, which is considered to be, is not intended to and essential material, and it provides antisepsis but right for preparation The toxic effect of eyes.The method of one common solution Anticorrosion is that product is packed as into single dose form.However, single dose Amount packaging is substantially more more expensive than multiple-unit container, adds the cost of finished product.Or pictureEqually, will pass through anti- The solution of corruption processing provides together with brush applicator that is disposable, being abandoned after.This is similarly greatly increased The cost of finished product.When eicosanoid is formulated as into non-aqueous based formulations, then preservative is not needed.So as to be able to use single painting Dauber carries out multidose delivering, easily portable and travelling.

In order to improve eyelashes/eyebrow hair growth product, health and appearance enhancing agent and nutrient can be added in preparation. For eyelashes, making its curling, (WO 2000074519, WO 2007078861, WO 20090136439, will in a manner of citation Its whole is included) and thus improve outward appearance and prevent from touching eyeball and prevent that ingrown composition from being useful.

The present invention relates to the non-aqueous based formulations of eicosanoid, its allow preparation without preservative and contribute to biologically active prod into The chemical stability divided.Non-aqueous and non-corrosion-resistant preparation of the invention comprising eicosanoid and nutrient/health-care components, the class Arachidic acid is, for example, prostanoid, particularly bimatoprost, tafluprost or travoprost, as described herein.It is non- The composition of aqueous formulation also includes essential oil and vegetable oil.Preferably, the cylindrical appliance equipped with felt/fiber tip is for eyelid The method of edge delivering.This delivering method brings economic advantages, such as waste it is less because with disposable brush phase Than product can be applied to the position of desired crinosity and reduce the waste of product to greatest extent by reused applicator. Dosage can be once every other day, once a day, twice daily or three times a day.The preparation can be applied to upper eyelid margin or lower eyelid Edge, eyebrow or scalp.

Eyelashes can be grown preparation using the special purpose device specially designed and accurately be delivered to margo palpebrae.Such as, it has been suggested that specially Door is used for accurate delivery to the special purpose device (US 20070160562) at required position.The contact jaw designed in device has brush Sub (WO2010065487) and roller (roller) device (US 20070160562).The shape of " tip " or rotational circle cylindricality Formula or felt/fiber tip.To help to deliver the required eicosanoid of therapeutic dose exactly, hydrostatic column can be used.Device The positive displacement of preparation can be made by piston (plunger) or ratchet (ratchet) (rotatably delivering preparation).Can be in cylinder Indexing on container, this contributes to the quantitative delivery of medicine.

Natural oil pharmaceutical preparation is directly delivered into required site of action (i.e. margo palpebrae) has the advantages of definite.Can be maximum Reduce to limit the position (such as on upper eyelid or eyelashes hair shaft) that medicine is applied to little or no crinosity benefit.Directly The possibility of medicament contact eyeball can also be reduced to greatest extent in margo palpebrae by delivering, and medicament contact eyeball may result in adversely Reduce intraocular pressure.Waste can be reduced to deliver natural oil preparation using felt/fiber tip forward direction displaced type device.Preparation continues In flowing/retention to tip, it is easy to supplement and is not easy to evaporate.This is different from aqueous formulation, and aqueous formulation is added on brush Or brush is immersed in aqueous formulation.In these cases, most of material is remained in brush and is not used by and with brush Son discarding and lose, and if violate manufacturer specification brush is retained and reused, these materials can also evaporate. In some cases, solution can also drop down from brush causes the waste of material.These brush smearing methods have economy The shortcomings that upper, and invention as described herein avoids these shortcomings.

Some eyelashes preparations are listed below：

Table 1

Preparation is numbered	1	2	3	4	5	6
							Bimatoprost (w/v)	0.01%	0.02%	0.03%	0.01%	0.02%	0.03%
Ethanol (v/v)	1%	1%	1%	1%	1%	1%
							Castor oil (v/v)	3%	3%	3%	3%	3%	3%
Jojoba oil (v/v)	96%	96%	96%	94-95.5%	94-95.5%	94-95.5%
							Essential oil (v/v)	0%	0%	0%	0.5-2%	0.5-2%	0.5-2%

The concentration that the present invention includes activating agent includes 3.0%w/v to 0.001%w/v, includes the ratio of for example following concentration Bimatoprost, travoprost or Latanoprost：3.0%th, 2.0%, 1.0%w/v, 0.9%w/v, 0.8%w/v, 0.7% W/v, 0.6%w/v, 0.5%w/v, 0.4%w/v, 0.3%w/v, 0.2%w/v, 0.1%w/v, 0.09%, 0.08%w/v, 0.07%w/v, 0.06%w/v, 0.05%w/v, 0.04%w/v, 0.03%w/v, 0.02%w/v, 0.01%w/v, 0.009% W/v, 0.008%w/v, 0.007%w/v, 0.006%w/v, 0.005%w/v, 0.004%w/v, 0.003%w/v, 0.002% W/v, 0.001%w/v.Other compositions include Lavender, deodar essential oil, thyme essential oil, Salvia japonica essential oil and rosemary Essential oil, avocado oil, Sweet Almond Oil and jojoba oil.

Other eyelashes preparations are as follows：

Table 2

Table 3

Table 4

Eyebrow grows preparation or hair of scalp growth preparation can be identical with preparation listed in table 1-4.

Embodiment 1

Bacterium and fungus growth

Experiment：The preparation prepared before 8 months (0.03% bimatoprost anhydrous formulation) is brushed in culture medium slide glass On (Microslides, LotionCraft, Cat#M-NUT/MAC), the preparation is：

0.03%w/v bimatoprost, 1%v/v ethanol, 3%v/v castor oil and 96%v/v jojoba oil (preparation 3, table 1)

Start Date：0th day

Close Date：10th day

Yellow face：For bacteriagrowthtest

Pink colour face：For saccharomycete and mould test

Step：

1) 0.03% bimatoprost anhydrous formulation is brushed on the two sides of the 1st group of (pack#1) culture medium slide glass, in room temperature Lower culture 10 days

2) negative control：The anhydrous system of 0.03% bimatoprost is brushed on the two sides of the 2nd group of (pack#2) culture medium slide glass Agent, without culture, take pictures immediately.

3) positive control of microorganism growth：Common micro- life is cultivated on the two sides of the 3rd group of (pack#3) culture medium slide glass Then thing, culture are taken pictures for two days.

The growth of observation microorganism daily is simultaneously taken pictures with to impinging upon the 10th day.

As a result：The photo of the 10th day, referring to Fig. 2.

Conclusion：Without discovery bacterium, saccharomycete on 0.03% tested bimatoprost anhydrous formulation or negative control Or mould.

Embodiment 2

The short and sparse Asia women of one eyelashes is once a day by (the table 1, by 0.03%w/v than horse forefront of preparation 3 The ethanol composition of element, 96%v/v jojoba oil, 3%v/v castor oil, 1%v/v) it is applied to upper eyelid margin.This by using Similar pen is realized equipped with the cylindrical container (referring to Fig. 1) of felt/fiber tip.Will by disposably displacement Bimatoprost preparation is applied to upper eyelid margin.After daily treatment 8 weeks, the length increase about 50% of eyelashes and eyelashes are totally obvious Ground is denser.

With correct expected embodiment：

Embodiment 3

One because of experience chemotherapy the sparse Caucasian female of eyelashes.The patient smear once a day preparation 13 (table 2, 0.02%w/v bimatoprost, 1%v/v ethanol, 3%v/v castor oil, 71.6%v/v jojoba oil, 24%v/v Sweet Almond Oil and 0.4%v/v vitamin E).After daily smear 60 days, patient's eyelashes it is thicker, longer before than treatment and It is more black.

Embodiment 4

One Spain male of 32 years old is with alopecia areata and starts alopecia.The patient smears the (table of preparation 31 once a day 4,0.3%w/v bimatoprost, 7%v/v ethanol, 3%v/v castor oil, 64.5%v/v jojoba oil, 12%v/ The dimension life of v olive oil, 12% Sweet Almond Oil, 0.5%v/v Rosemary Oil, 0.5%v/v tea oil, 0.5%v/v Plain E).After the preparation is smeared, the scalp of patient grows new hair and the symptom of alopecia areata is improved.

Embodiment 5

One Caucasian female of 51 years old finds that her eyebrow is more and more sparse.This 51 years old Caucasian female has smeared preparation 25 (table 3,0.1%w/v bimatoprost, 3%v/v ethanol, 3%v/v castor oil, 68.5%v/v jojoba oil, 8%v/v avocado oil, 8%v/v olive oil, 8%v/v Sweet Almond Oil, 0.5%v/v Rosemary Oil, 0.5%v/v Tea oil, 0.5%v/v vitamin E).After smearing 60 days twice daily, the increase of eyebrow density, the length increase of patient, And become thicker, denser.

Claims (10)

1. a kind of non-aqueous non-preservative for being used to stimulate hair growth, it includes eicosanoid, ethanol and oil, wherein class Arachidic acid exists with about 0.01%-0.3%w/v concentration and ethanol exists with about 1%-7%v/v concentration.

2. the preparation of claim 1, wherein the eicosanoid is bimatoprost, the oil is vegetable oil.

3. the preparation of claim 1, wherein the vegetable oil is selected from Lavender, cedar essence oil, thyme essential oil, rat-tail Careless essential oil, Rosemary Oil, tea oil, fleece-flower root oil, castor oil, jojoba oil, avocado oil, olive oil, Sweet Almond Oil, dimension life Plain E.

4. the preparation of Claims 2 or 3, wherein the preparation is used to stimulate eyelashes to grow and comprising about 0.02-0.03%w/v's Bimatoprost.

5. the preparation of claim 4, it includes about 0.03%w/v bimatoprost, about 1%v/v ethanol, about 3%v/v Castor oil and about 96%v/v jojoba oil.

6. the preparation of claim 4, it includes about 0.02%w/v bimatoprost, about 1%v/v ethanol, about 3%v/v Castor oil and about 71.6%v/v jojoba oil, about 24%v/v Sweet Almond Oil and about 0.4%v/v vitamin E.

7. the preparation of Claims 2 or 3, wherein the preparation is used to stimulate scalp to grow and comprising about 0.01%-0.3%w/v Bimatoprost.

8. the preparation of claim 7, its include 0.3%w/v bimatoprost, 7%v/v ethanol, 3%v/v castor oil, 64.5%v/v jojoba oil, 12%v/v olive oil, 12% Sweet Almond Oil, 0.5%v/v rosemary oil, 0.5%v/ V tea oil, 0.5%v/v vitamin E.

9. the preparation of Claims 2 or 3, wherein the preparation is used to stimulate eyebrow to grow and comprising about 0.01%-0.3%w/v Bimatoprost.

10. the preparation of claim 9, it includes 0.1%w/v bimatoprost, 3%v/v ethanol, 3%v/v castor-oil plant Oil, 68.5%v/v jojoba oil, 8%v/v avocado oil, 8%v/v olive oil, 8%v/v Sweet Almond Oil, 0.5%v/ V rosemary oil, 0.5%v/v tea oil, 0.5%v/v vitamin E.