CN107569637A - Chinese medicine composition for treating hepatic sclerosis and preparation method and application - Google Patents
Chinese medicine composition for treating hepatic sclerosis and preparation method and application Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition for being used to treat hepatic sclerosis and preparation method and application, the raw material components of Chinese medicine composition include：Safflower, cudrania root, full worm, leech, honeysuckle, stir-baked SQUAMA MANITIS, rhodiola root, galingal, frankincense, rhubarb, garden burnet, Radix Isatidis, the red sage root, cortex magnoliae officinalis processed, stringy stonecrop, extra large viper, folium isatidis, astragali, liver moss, the fruit of Chinese magnoliavine, rhizoma atractylodis and oriental wormwood；Preparation method：Extracted after each raw material components are crushed, collect extract solution；Thick paste is condensed into afterwards, obtains Chinese medicine composition.The Chinese medicine composition of the present invention selects active skull cap components, component compatibility science, safe without toxic side effect, there is the effect of excellent dispersing stagnated hepatoqi, promoting blood circulation and removing blood stasis, softening and resolving hard mass, Nourishing Kidney liver, have good therapeutic action especially for early metaphase hepatic sclerosis and patients with liver deficiency；Chinese medicine composition clinical effectiveness of the present invention is good, symptom disappears, and rapid, treatment cycle is short, cure after do not rebound, treatment cost it is low, be effectively reduced the financial burden of patient.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, and in particular to a kind of Chinese medicine composition and its system for being used to treat hepatic sclerosis
Preparation Method and application.
Background technology
In recent years, with China's industrialization and the quickening of Development of China's Urbanization, problem of environmental pollution getting worse, various diseases
Emerge in an endless stream.According to statistics：The whole world has more than 100 ten thousand patients to die from hepatopathy every year, and China is the popular more serious country of hepatopathy.
Wherein, the hepatic sclerosis chronic progressive hepatopathy common as a kind of clinic, it is by one or more causes of disease are long-term or repeated action
The diffusivity hepatic lesion of formation.
It is posthepatitic cirrhosis in most of China, small part is alcoholic cirrhosis and Cirrhosis In Schistosomiasis.Pathology
There are extensive necrosis of liver cells, regeneration of remaining liver cell nodules, connective tissue proliferation and fiber in histology every formation, cause
Lobuli hepatis structure is destroyed and pseudolobuli is formed, and liver gradually deforms, is hardened and develops into hepatic sclerosis.Early stage is due to the compensatory work(of liver
Can more by force can non-evident sympton, stage has multisystem involvement, late period using hepatic disorder and portal hypertension as main performance
Often there are the complication such as UGB, hepatic encephalopathy, scabies secondary infection, hypersplenia, ascites, canceration.By etiological classification
Virus hepatitis hepatic sclerosis, alcoholic cirrhosis, metabolic hepatic sclerosis, Cholestatic cirrhosis, vena hepatica backflow can be divided into
It is hard by resistive hepatic sclerosis, autoimmune cirrhosis, poisonous substance and drug induced liver cirrhosis, nutritional cirrhosis, hidden source property liver
Change.
Cause the cause of disease of hepatic sclerosis a lot, wherein mainly caused by virus hepatitis, such as hepatitis B, hepatitis.Also have simultaneously
Caused by the factor long-term damage of alcoholic liver, fatty liver, cholestasis, medicine, nutrition etc..
The Chinese medicine majority for the treatment of hepatic sclerosis helps out at present, is generally used for alleviating or treats one of hepatic sclerosis
Small aspect；Such as：With clearing heat and detoxicating, phlegm reduction of blood circulation promoting prescription suppressing virus replication；With nourishing qi and blood, the side of clearing heat and promoting diuresis removing toxic substances
Medicine adjusts immunologic function, removes virus；With expectorant powder junction, decoction for the treatment megalosplenia promoting blood circulation and removing blood stasis；Led to promoting blood circulation and removing blood stasis, liver of relaxing
Network, the prescription Softing liver and contracting spleen of expectorant powder junction, portal hypertension is reduced, block and reverse liver fibrosis, hepatic sclerosis etc..But deposit on the market
Such curative effect of medication it is poor and with high costs, so as to can not effectively cure such disease, reduce patient's pain.Based on this,
Need a kind of new, evident in efficacy and lower-cost medicine that can treat hepatic sclerosis badly.
The content of the invention
For in the prior art the defects of, the present invention is intended to provide it is a kind of be used for treat hepatic sclerosis Chinese medicine composition and its
Preparation method and application.Chinese medicine composition provided by the invention makees raw material components from active skull cap components, component compatibility science,
Safe without toxic side effect, there is the effect of excellent dispersing stagnated hepatoqi, promoting blood circulation and removing blood stasis, softening and resolving hard mass, Nourishing Kidney liver, can be with effective
In treatment hepatic sclerosis, there is good therapeutic action especially for early metaphase hepatic sclerosis and patients with liver deficiency；And Chinese medicine of the present invention
Composition clinical effectiveness is good, symptom disappears, and rapid, treatment cycle is short, cure after do not rebound, treatment cost it is low, can effectively mitigate
The financial burden of patient.
Therefore, the present invention provides following technical scheme：
In a first aspect, the present invention provides a kind of Chinese medicine composition, raw material components by weight, including：Safflower 5~8
Parts by weight, the parts by weight of cudrania root 2~5, the parts by weight of full worm 6~9, the parts by weight of leech 1~3, the parts by weight of honeysuckle 3~5, stir-baked SQUAMA MANITIS
1~2 parts by weight, the parts by weight of rhodiola root 8~10, the parts by weight of galingal 2~3, the parts by weight of frankincense 2~3, the parts by weight of rhubarb 1~3,
The parts by weight of garden burnet 3~4, the parts by weight of Radix Isatidis 3~6, the parts by weight of the red sage root 2~6, the parts by weight of cortex magnoliae officinalis processed 2~3 and stringy stonecrop 1~3
Parts by weight.
In the further embodiment of the present invention, raw material components also include：The extra large parts by weight of viper 2~5, astragali 0.6~0.9
Parts by weight, the parts by weight of folium isatidis 8~10 and the parts by weight of liver moss 0.5~1.8.
In the further embodiment of the present invention, raw material components also include：The parts by weight of the fruit of Chinese magnoliavine 0.2~0.5, rhizoma atractylodis
0.1~0.2 parts by weight and the parts by weight of oriental wormwood 1~2.
In the further embodiment of the present invention, raw material components include：The parts by weight of safflower 6~8, the weight of cudrania root 3~5
Measure part, the parts by weight of full worm 6~7, the parts by weight of leech 2~3, the parts by weight of honeysuckle 3~4, the parts by weight of stir-baked SQUAMA MANITIS 1~2, rhodiola root 8
~9 parts by weight, the parts by weight of galingal 2~3, the parts by weight of frankincense 2~3, the parts by weight of rhubarb 1~2, the parts by weight of garden burnet 3~4, plate are blue
The parts by weight of root 3~4, the parts by weight of the red sage root 3~6, the parts by weight of cortex magnoliae officinalis processed 2~3, the parts by weight of stringy stonecrop 1~2, the parts by weight of extra large viper 2~4,
The parts by weight of folium isatidis 8~10, the parts by weight of astragali 0.6~0.9, the parts by weight of liver moss 0.8~1.3, the parts by weight of the fruit of Chinese magnoliavine 0.2~0.3,
The parts by weight of rhizoma atractylodis 0.1~0.2 and the parts by weight of oriental wormwood 1~2.
In the further embodiment of the present invention, Chinese medicine composition is in paste, sheet or pellet.
Second aspect, the present invention provide a kind of preparation method of Chinese medicine composition, comprised the following steps：S101：By each original
Material component clean, dry after crush；Raw material components after crushing are extracted using the first mixture, collect extract solution；
S102：Relative density is 1.15~1.35 thick paste when extract solution is condensed into 70 DEG C, obtains Chinese medicine composition.
In the further embodiment of the present invention, in S101, the weight ratio of raw material components and the first mixture is 1：(5
~10) 60~200 mesh, and by each raw material components are crushed to.
In the further embodiment of the present invention, in S101, it is 1 that the raw material components of the first mixture, which include mass ratio,：
The honey and water of (10~20).
In the further embodiment of the present invention, in S101, the condition of extraction is：In the bar that temperature is 45 DEG C~55 DEG C
Refluxing extraction 5h~10h under part, the number of extraction are at least 1 time and preferably 3 times.
The third aspect, Chinese medicine composition provided by the invention add in preparation for the medicine and/or medicine for treating hepatic sclerosis
Add the application in agent.
Above-mentioned technical proposal provided by the invention has advantages below：
(1) applicant has found by many experiments：Chinese medicine composition provided by the invention is made former from active skull cap components
Expect component, component compatibility science, safe without toxic side effect, there is excellent dispersing stagnated hepatoqi, promoting blood circulation and removing blood stasis, softening and resolving hard mass, nourshing kidney
The effect of soft liver, can have well especially for early metaphase hepatic sclerosis and patients with liver deficiency effective for treating hepatic sclerosis
Therapeutic action；And Chinese medicine composition clinical effectiveness of the present invention is good, symptom disappears that rapid, treatment cycle is short, cure after do not rebound, control
It is low to treat cost, can effectively mitigate the financial burden of patient, there is extensive practical value.
(2) preparation method provided by the invention is simple, production cost is relatively low, workable, is advantageous to follow-up scale
Change application；And using preparation method provided by the invention can while each raw material active component is retained to greatest extent,
Active ingredient in each raw material components fully discharges, and finally makes it have the effect of excellent.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following examples are only used for clearer
Explanation technical scheme, therefore be only used as example, and can not be limited the scope of the invention with this.
Experimental method in following embodiments, it is conventional method unless otherwise specified.
Test material used, is to be commercially available from conventional reagent shop unless otherwise specified in following embodiments.
Quantitative test in following examples, it is respectively provided with and repeats to test three times, data is to repeat the average value of experiment three times
Or mean+SD.
Safflower used in following embodiments, cudrania root, full worm, leech, honeysuckle, stir-baked SQUAMA MANITIS, rhodiola root, galingal,
Frankincense, rhubarb, garden burnet, Radix Isatidis, the red sage root, cortex magnoliae officinalis processed, stringy stonecrop, extra large viper, folium isatidis, astragali, liver moss, the fruit of Chinese magnoliavine, rhizoma atractylodis
And oriental wormwood meets the pertinent regulations under each medicinal material item of text of Chinese Pharmacopoeia (version in 2015).Before feeding intake, by identifying,
Ingredients material object is consistent with title, and quality meets standard.
The present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of safflower 5~8, wear
The broken parts by weight of stone 2~5, the parts by weight of full worm 6~9, the parts by weight of leech 1~3, the parts by weight of honeysuckle 3~5, the weight of stir-baked SQUAMA MANITIS 1~2
Part, the parts by weight of rhodiola root 8~10, the parts by weight of galingal 2~3, the parts by weight of frankincense 2~3, the parts by weight of rhubarb 1~3, garden burnet 3~4
Parts by weight, the parts by weight of Radix Isatidis 3~6, the parts by weight of the red sage root 2~6, the parts by weight of cortex magnoliae officinalis processed 2~3 and the parts by weight of stringy stonecrop 1~3.
Preferably, raw material components also include：The extra large parts by weight of viper 2~5, the parts by weight of folium isatidis 8~10, the weight of astragali 0.6~0.9
Measure part and the parts by weight of liver moss 0.5~1.8.
Preferably, raw material components also include：The parts by weight of the fruit of Chinese magnoliavine 0.2~0.5, the parts by weight of rhizoma atractylodis 0.1~0.2 and oriental wormwood
1~2 parts by weight.
In addition, being directed to Chinese medicine composition provided by the invention, the invention provides the side for specially preparing the Chinese medicine composition
Method, comprise the following steps：
S101：Crushed after each raw material components are cleaned, dried；Raw material components after crushing are carried out using the first mixture
Extraction, collect extract solution.Wherein, the weight of raw material components and the first mixture ratio is 1：(5~10), and by each raw material components powder
It is broken to 60~200 mesh；It is 1 that the raw material components of first mixture, which include mass ratio,：The honey and water of (10~20)；The condition of extraction
For：Refluxing extraction 5h~10h under conditions of being 45 DEG C~55 DEG C in temperature, the number of extraction are at least 1 time and preferably 3 times.
S102：Relative density is 1.15~1.35 thick paste when extract solution is condensed into 70 DEG C, obtains Chinese medicine composition.
Illustrated with reference to embodiment：
Embodiment one
The present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of safflower 6, cudrania root
It is 5 parts by weight, the parts by weight of full worm 6, the parts by weight of leech 3, the parts by weight of honeysuckle 4, the parts by weight of stir-baked SQUAMA MANITIS 1, the parts by weight of rhodiola root 8, good
The parts by weight of ginger 3, the parts by weight of frankincense 3, the parts by weight of rhubarb 1, the parts by weight of garden burnet 3, the parts by weight of Radix Isatidis 4, the parts by weight of the red sage root 3, system
The parts by weight of cortex magnoliae officinalis 3 and the parts by weight of stringy stonecrop 2.
By above-mentioned raw materials component, the preparation method of Chinese medicine composition provided by the invention is respectively adopted, prepares Chinese traditional medicine composition
Thing：
S101：200 mesh are crushed to after each raw material components are cleaned, dried；Raw material components after crushing are mixed using first
Refluxing extraction 5h under conditions of compound is 55 DEG C in temperature, the number of extraction is 3 times, collects extract solution afterwards.Wherein, raw material group
It is 1 to divide with the weight ratio of the first mixture：10, it is 1 that the raw material components of the first mixture, which include mass ratio,：10 honey and water.
S102：Relative density is 1.15~1.35 thick paste when extract solution is condensed into 70 DEG C, obtains Chinese medicine composition.
Embodiment two
The present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of safflower 8, cudrania root
It is 3 parts by weight, the parts by weight of full worm 7, the parts by weight of leech 2, the parts by weight of honeysuckle 3, the parts by weight of stir-baked SQUAMA MANITIS 2, the parts by weight of rhodiola root 9, good
The parts by weight of ginger 2, the parts by weight of frankincense 2, the parts by weight of rhubarb 2, the parts by weight of garden burnet 4, the parts by weight of Radix Isatidis 3, the parts by weight of the red sage root 6, system
The parts by weight of cortex magnoliae officinalis 2 and the parts by weight of stringy stonecrop 1.
By above-mentioned raw materials component, the preparation method of Chinese medicine composition provided by the invention is respectively adopted, prepares Chinese traditional medicine composition
Thing：
S101：60 mesh are crushed to after each raw material components are cleaned, dried；By the raw material components after crushing using the first mixing
Refluxing extraction 10h under conditions of thing is 45 DEG C in temperature, the number of extraction is 3 times, collects extract solution afterwards.Wherein, raw material group
It is 1 to divide with the weight ratio of the first mixture：5, it is 1 that the raw material components of the first mixture, which include mass ratio,：20 honey and water.
S102：Relative density is 1.15~1.35 thick paste when extract solution is condensed into 70 DEG C, obtains Chinese medicine composition.
Embodiment three
The present embodiment sets on the basis of embodiment one and formed.
The present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of safflower 6, cudrania root
It is 5 parts by weight, the parts by weight of full worm 6, the parts by weight of leech 3, the parts by weight of honeysuckle 4, the parts by weight of stir-baked SQUAMA MANITIS 1, the parts by weight of rhodiola root 8, good
The parts by weight of ginger 3, the parts by weight of frankincense 3, the parts by weight of rhubarb 1, the parts by weight of garden burnet 3, the parts by weight of Radix Isatidis 4, the parts by weight of the red sage root 3, system
The parts by weight of cortex magnoliae officinalis 3, the parts by weight of stringy stonecrop 2, the parts by weight of extra large viper 4, the parts by weight of folium isatidis 8, the parts by weight of astragali 0.6 and liver moss 1.3
Parts by weight.
By above-mentioned raw materials component, the preparation method of Chinese medicine composition provided by the invention is respectively adopted, prepares Chinese traditional medicine composition
Thing：
S101：200 mesh are crushed to after each raw material components are cleaned, dried；Raw material components after crushing are mixed using first
Refluxing extraction 5h under conditions of compound is 55 DEG C in temperature, the number of extraction is 3 times, collects extract solution afterwards.Wherein, raw material group
It is 1 to divide with the weight ratio of the first mixture：10, it is 1 that the raw material components of the first mixture, which include mass ratio,：10 honey and water.
S102：Relative density is 1.15~1.35 thick paste when extract solution is condensed into 70 DEG C, obtains Chinese medicine composition.
Example IV
The present embodiment sets on the basis of embodiment two and formed.
The present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of safflower 8, cudrania root
It is 3 parts by weight, the parts by weight of full worm 7, the parts by weight of leech 2, the parts by weight of honeysuckle 3, the parts by weight of stir-baked SQUAMA MANITIS 2, the parts by weight of rhodiola root 9, good
The parts by weight of ginger 2, the parts by weight of frankincense 2, the parts by weight of rhubarb 2, the parts by weight of garden burnet 4, the parts by weight of Radix Isatidis 3, the parts by weight of the red sage root 6, system
The parts by weight of cortex magnoliae officinalis 2, the parts by weight of stringy stonecrop 1, the parts by weight of extra large viper 2, the parts by weight of folium isatidis 10, the parts by weight of astragali 0.9 and liver moss 0.8
Parts by weight.
By above-mentioned raw materials component, the preparation method of Chinese medicine composition provided by the invention is respectively adopted, prepares Chinese traditional medicine composition
Thing：
S101：60 mesh are crushed to after each raw material components are cleaned, dried；By the raw material components after crushing using the first mixing
Refluxing extraction 10h under conditions of thing is 45 DEG C in temperature, the number of extraction is 3 times, collects extract solution afterwards.Wherein, raw material group
It is 1 to divide with the weight ratio of the first mixture：5, it is 1 that the raw material components of the first mixture, which include mass ratio,：20 honey and water.
S102：Relative density is 1.15~1.35 thick paste when extract solution is condensed into 70 DEG C, obtains Chinese medicine composition.
Embodiment five
The present embodiment sets on the basis of embodiment three and formed.
The present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of safflower 6, cudrania root
It is 5 parts by weight, the parts by weight of full worm 6, the parts by weight of leech 3, the parts by weight of honeysuckle 4, the parts by weight of stir-baked SQUAMA MANITIS 1, the parts by weight of rhodiola root 8, good
The parts by weight of ginger 3, the parts by weight of frankincense 3, the parts by weight of rhubarb 1, the parts by weight of garden burnet 3, the parts by weight of Radix Isatidis 4, the parts by weight of the red sage root 3, system
The parts by weight of cortex magnoliae officinalis 3, the parts by weight of stringy stonecrop 2, the parts by weight of extra large viper 4, the parts by weight of folium isatidis 8, the parts by weight of astragali 0.6, the weight of liver moss 1.3
Part, the parts by weight of the fruit of Chinese magnoliavine 0.2, the parts by weight of rhizoma atractylodis 0.2 and the parts by weight of oriental wormwood 2.
By above-mentioned raw materials component, the preparation method of Chinese medicine composition provided by the invention is respectively adopted, prepares Chinese traditional medicine composition
Thing：
S101：200 mesh are crushed to after each raw material components are cleaned, dried；Raw material components after crushing are mixed using first
Refluxing extraction 5h under conditions of compound is 55 DEG C in temperature, the number of extraction is 3 times, collects extract solution afterwards.Wherein, raw material group
It is 1 to divide with the weight ratio of the first mixture：10, it is 1 that the raw material components of the first mixture, which include mass ratio,：10 honey and water.
S102：Relative density is 1.15~1.35 thick paste when extract solution is condensed into 70 DEG C, obtains Chinese medicine composition.
Embodiment six
The present embodiment sets on the basis of example IV and formed.
The present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of safflower 8, cudrania root
It is 3 parts by weight, the parts by weight of full worm 7, the parts by weight of leech 2, the parts by weight of honeysuckle 3, the parts by weight of stir-baked SQUAMA MANITIS 2, the parts by weight of rhodiola root 9, good
The parts by weight of ginger 2, the parts by weight of frankincense 2, the parts by weight of rhubarb 2, the parts by weight of garden burnet 4, the parts by weight of Radix Isatidis 3, the parts by weight of the red sage root 6, system
The parts by weight of cortex magnoliae officinalis 2, the parts by weight of stringy stonecrop 1, the parts by weight of extra large viper 2, the parts by weight of folium isatidis 10, the parts by weight of astragali 0.9, the weight of liver moss 0.8
Measure part, the parts by weight of the fruit of Chinese magnoliavine 0.3, the parts by weight of rhizoma atractylodis 0.1 and the parts by weight of oriental wormwood 1.
By above-mentioned raw materials component, the preparation method of Chinese medicine composition provided by the invention is respectively adopted, prepares Chinese traditional medicine composition
Thing：
S101：60 mesh are crushed to after each raw material components are cleaned, dried；By the raw material components after crushing using the first mixing
Refluxing extraction 10h under conditions of thing is 45 DEG C in temperature, the number of extraction is 3 times, collects extract solution afterwards.Wherein, raw material group
It is 1 to divide with the weight ratio of the first mixture：5, it is 1 that the raw material components of the first mixture, which include mass ratio,：20 honey and water.
S102：Relative density is 1.15~1.35 thick paste when extract solution is condensed into 70 DEG C, obtains Chinese medicine composition.
Embodiment seven
The present embodiment sets on the basis of embodiment six and formed.
The present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of safflower 8, cudrania root
3 parts by weight, the parts by weight of full worm 7, the parts by weight of leech 2, the parts by weight of rhodiola root 9, the parts by weight of galingal 2, the parts by weight of garden burnet 4, Radix Isatidis 3
Parts by weight, the parts by weight of the red sage root 6, the parts by weight of stringy stonecrop 1, the parts by weight of extra large viper 2, the parts by weight of folium isatidis 10, the parts by weight of liver moss 0.8, five
The parts by weight of taste 0.3 and the parts by weight of oriental wormwood 1.
By above-mentioned raw materials component, the preparation method of Chinese medicine composition provided by the invention is respectively adopted, prepares Chinese traditional medicine composition
Thing：
S101：60 mesh are crushed to after each raw material components are cleaned, dried；It is in temperature with water by the raw material components after crushing
Refluxing extraction 10h under conditions of 45 DEG C, the number of extraction is 3 times, collects extract solution afterwards.Wherein, the weight of raw material components and water
Amount is than being 1：5.
S102：Relative density is 1.15~1.35 thick paste when extract solution is condensed into 70 DEG C, obtains Chinese medicine composition.
In addition, the Chinese medicine composition that various embodiments of the present invention are obtained, by function assessment experiment come its effect of system evaluation：
First, toxicity test
The small white mouse 70 (each 35 of male and female) for selecting body weight to be 18~22g, the Chinese medicine composition 10g of the present invention is taken, is added
Ion water making is into concentrate 20mL, and every small white mouse gives concentrate 0.5mL gavages, twice daily；Observation 15 days, small white mouse is equal
Health existence, has no toxic side effect；Anatomic observation blood picture, liver function, each organs and tissues state, the indifference compared with normal small white mouse
It is different.It is demonstrated experimentally that Chinese medicine composition provided by the invention is nontoxic.
2nd, animal experiment
100 250 ± 20g of body weight healthy male rat is chosen, is averaged and is divided into 10 groups；First group to the 9th group is
Modeling group, the tenth group is control group.100%CCl is subcutaneously injected in modeling group rat first43mL/kg, thereafter 50%CCl4Olive oil
Solution 2mL/kg, 2 times a week, totally 9 weeks；Normal rats inject the olive oil with dosage.By modeling component to control after modeling 6 weeks
Treatment group, liver-protecting tablet group and model group.Wherein, first group to the 7th group is treatment group, tries out embodiment one respectively to embodiment seven
In Chinese medicine composition；8th group of marketed drugs liver-protecting tablet on probation；9th group is model group；Each group according to 50mg/kg dosage
Gavage 20 days, once a day；Afterwards by each group residue rat with 2% barbital sodium intraperitoneal injection of anesthesia after, inferior caval vein blood sampling,
And take hepatic tissue sample.Observe and record the strong proline of hepatic tissue (Hyp) content (JamallShi methods)；Serum ALT, AST, GGT
Activity and serum Alb, Tbil content, concrete outcome is as shown in Table 1 and Table 2.
The present invention of table 1 is to one of indices data of hepatic lesion rat
| Dosage (mg/kg) | Hyp(μg/g) | ALT(U/mL) | AST(U/mL) | |
| Control group | -- | 136.23±30.07 | 32.36±11.70 | 48.28±9.52 |
| Liver-protecting tablet group | 50 | 293.3±101.23 | 107.36±33.70 | 103.51±20.93 |
| Embodiment one | 50 | 252.9±83.19 | 91.91±21.03 | 93.03±21.02 |
| Embodiment two | 50 | 257.92±71.08 | 90.88±27.12 | 89.93±20.82 |
| Embodiment three | 50 | 227.76±80.99 | 75.83±20.08 | 81.38±16.12 |
| Example IV | 50 | 229.83±89.82 | 79.80±18.02 | 80.91±20.93 |
| Embodiment five | 50 | 212.62±51.78 | 63.70±15.32 | 72.96±15.02 |
| Embodiment six | 50 | 209.34±61.29 | 61.71±13.03 | 71.29±12.51 |
| Embodiment seven | 50 | 258.56±81.58 | 88.62±21.62 | 83.81±11.53 |
| Model group | -- | 383.31±61.23 | 173.26±25.07 | 148.28±31.52 |
The two of the indices data of the invention to hepatic lesion rat of table 2
| Dosage (mg/kg) | GGT(U/mL) | Tbil(mg/dL) | alb(g/L) | |
| Control group | -- | 11.23±2.07 | 0.56±0.40 | 38.28±1.52 |
| Liver-protecting tablet group | 50 | 33.36±11.23 | 1.06±0.38 | 30.51±1.93 |
| Embodiment one | 50 | 26.89±10.19 | 0.91±0.23 | 32.03±2.02 |
| Embodiment two | 50 | 27.92±10.08 | 0.88±0.22 | 31.93±2.82 |
| Embodiment three | 50 | 25.76±8.99 | 0.79±0.18 | 33.38±1.12 |
| Example IV | 50 | 24.83±9.82 | 0.80±0.22 | 33.91±1.93 |
| Embodiment five | 50 | 22.62±8.78 | 0.70±0.32 | 34.96±1.02 |
| Embodiment six | 50 | 21.34±10.29 | 0.68±0.13 | 33.99±1.51 |
| Embodiment seven | 50 | 28.86±10.58 | 0.82±0.32 | 31.81±1.53 |
| Model group | -- | 56.23±10.07 | 1.26±0.67 | 28.28±2.52 |
2nd, clinical trial
Call-up age 60 (M-Fs 1 of the hepatic sclerosis volunteer of 25~60 years old:1) each patient, is divided into 6 groups,
Every group of 10 people, by first group to the 6th group respectively try out embodiment one to embodiment six in Chinese medicine composition, each 5g, daily
Once.The concrete condition of each patient is counted after two courses for the treatment of, it is specific as shown in table 3.
Curative effect is judged as：
It is effective：After the course for the treatment of terminates, symptom, sign disappear or basic disappearance；There is the disappearance of ascites person's ascites；Liver function recovery is just
Often；Portal vein width reduces by 0.3~0.5cm before relatively treating, and thickness of spleen is retracted beyond 0.5cm.
Effectively：After the course for the treatment of terminates, symptom, sign classification reduce more than 1 grade, but not disappeared；There is the mitigation of ascites person's ascites
More than 50% and be not wholly absent；Liver function index fall is not more than 50% and completely normal；Portal vein width is relatively controlled
0.1~0.2cm, 0.3~0.5cm of thickness of spleen retraction are reduced before treating.
It is invalid：Not up to above-mentioned standard or add severe one.
Obvious effective rate：Effective number of cases/treatment group's number of cases × 100%；Total effective rate=(effective number of cases+effective number of cases)/treatment
Group number of cases × 100%.
The clinical effectiveness statistical form of each embodiment Chinese medicine composition of table 3
| It is effective | Effectively | It is invalid | Obvious effective rate/% | Total effective rate/% | |
| Embodiment one | 5 | 5 | 0 | 50 | 100 |
| Embodiment two | 5 | 5 | 0 | 50 | 100 |
| Embodiment three | 7 | 3 | 0 | 50 | 100 |
| Example IV | 7 | 3 | 0 | 50 | 100 |
| Embodiment five | 9 | 1 | 0 | 90 | 100 |
| Embodiment six | 10 | 0 | 0 | 100 | 100 |
Certainly, except the situation that embodiment one is enumerated to embodiment six, the percentage by weight of other raw material components, prepared
Each condition and parameter in journey etc. are also possible.
Chinese medicine composition provided by the invention makees raw material components, component compatibility science, safe nothing from active skull cap components
Toxic side effect, there is the effect of excellent dispersing stagnated hepatoqi, promoting blood circulation and removing blood stasis, softening and resolving hard mass, Nourishing Kidney liver, can be effective for treatment
Hepatic sclerosis, there is good therapeutic action especially for early metaphase hepatic sclerosis and patients with liver deficiency；And Chinese medicine composition of the present invention
Clinical effectiveness is good, symptom disappears, and rapid, treatment cycle is short, cure after do not rebound, treatment cost it is low, can effectively mitigate patient's
Financial burden, there is extensive practical value.In addition, the preparation method of the present invention is simple, production cost is relatively low, operability
By force, follow-up scale application is advantageous to.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or the spy for combining the embodiment or example description
Point is contained at least one embodiment or example of the present invention.In this manual, to the schematic representation of above-mentioned term not
Identical embodiment or example must be directed to.Moreover, specific features, structure, material or the feature of description can be with office
Combined in an appropriate manner in one or more embodiments or example.In addition, in the case of not conflicting, the skill of this area
Art personnel can be tied the different embodiments or example and the feature of different embodiments or example described in this specification
Close and combine.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is example
Property, it is impossible to limitation of the present invention is interpreted as, one of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changed, replacing and modification.
Claims (10)
- A kind of 1. Chinese medicine composition, it is characterised in that raw material components by weight, including：The parts by weight of safflower 5~8, the parts by weight of cudrania root 2~5, the parts by weight of full worm 6~9, the parts by weight of leech 1~3, honeysuckle 3~ 5 parts by weight, the parts by weight of stir-baked SQUAMA MANITIS 1~2, the parts by weight of rhodiola root 8~10, the parts by weight of galingal 2~3, the parts by weight of frankincense 2~3, system are big Yellow 1~3 parts by weight, the parts by weight of garden burnet 3~4, the parts by weight of Radix Isatidis 3~6, the parts by weight of the red sage root 2~6, the parts by weight of cortex magnoliae officinalis processed 2~3 And the parts by weight of stringy stonecrop 1~3.
- 2. Chinese medicine composition according to claim 1, it is characterised in that also include：The extra large parts by weight of viper 2~5, the parts by weight of folium isatidis 8~10, the parts by weight of astragali 0.6~0.9 and the weight of liver moss 0.5~1.8 Part.
- 3. Chinese medicine composition according to claim 2, it is characterised in that also include：The parts by weight of the fruit of Chinese magnoliavine 0.2~0.5, the parts by weight of rhizoma atractylodis 0.1~0.2 and the parts by weight of oriental wormwood 1~2.
- 4. Chinese medicine composition according to claim 3, it is characterised in that including：The parts by weight of safflower 6~8, the parts by weight of cudrania root 3~5, the parts by weight of full worm 6~7, the parts by weight of leech 2~3, honeysuckle 3~ 4 parts by weight, the parts by weight of stir-baked SQUAMA MANITIS 1~2, the parts by weight of rhodiola root 8~9, the parts by weight of galingal 2~3, the parts by weight of frankincense 2~3, system are big Yellow 1~2 parts by weight, the parts by weight of garden burnet 3~4, the parts by weight of Radix Isatidis 3~4, the parts by weight of the red sage root 3~6, the parts by weight of cortex magnoliae officinalis processed 2~3, The parts by weight of stringy stonecrop 1~2, the parts by weight of extra large viper 2~4, the parts by weight of folium isatidis 8~10, the parts by weight of astragali 0.6~0.9, liver moss 0.8 ~1.3 parts by weight, the parts by weight of the fruit of Chinese magnoliavine 0.2~0.3, the parts by weight of rhizoma atractylodis 0.1~0.2 and the parts by weight of oriental wormwood 1~2.
- 5. according to the Chinese medicine composition described in any one of Claims 1 to 4, it is characterised in that：The Chinese medicine composition is in paste, sheet or pellet.
- 6. the preparation method of the Chinese medicine composition described in any one of Claims 1 to 5, it is characterised in that comprise the following steps：S101：Crushed after each raw material components are cleaned, dried；Raw material components after the crushing are carried out using the first mixture Extraction, collect extract solution；S102：Relative density is 1.15~1.35 thick paste when the extract solution is condensed into 70 DEG C, obtains the Chinese traditional medicine composition Thing.
- 7. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that：In the S101, the weight ratio of the raw material components and first mixture is 1：(5~10), and by each raw material components It is crushed to 60~200 mesh.
- 8. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that：In the S101, it is 1 that the raw material components of first mixture, which include mass ratio,：The honey and water of (10~20).
- 9. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that：In the S101, the condition of the extraction is：Refluxing extraction 5h~10h under conditions of being 45 DEG C~55 DEG C in temperature, institute The number for stating extraction is at least 1 time and preferably 3 times.
- 10. the Chinese medicine composition described in any one of Claims 1 to 5 is preparing medicine and/or medicine for treating hepatic sclerosis Application in additive.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108159351A (en) * | 2018-02-01 | 2018-06-15 | 重庆跃龙生物制药有限公司 | Chinese medicine composition for treating cirrhotic ascites and preparation method thereof |
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